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Gene: AGT (angiotensinogen) Homo sapiens
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Symbol: AGT
Name: angiotensinogen
Description: Exhibits angiotensin receptor binding activity and molecular function regulator. Involved in several processes, including positive regulation of branching involved in ureteric bud morphogenesis; positive regulation of cellular metabolic process; and regulation of signal transduction. Localizes to the extracellular space. Implicated in several diseases, including Fabry disease; Henoch-Schoenlein purpura; artery disease (multiple); heart conduction disease (multiple); and hydronephrosis. Biomarker of several diseases, including alcoholic hepatitis; autoimmune hypersensitivity disease (multiple); chronic myeloid leukemia; intermediate coronary syndrome; and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: alpha-1 antiproteinase, antitrypsin; angiotensin I; angiotensin II; angiotensinogen (serine (or cysteine) proteinase inhibitor, clade a (alpha-1 antiproteinase, antitrypsin), member 8); angiotensinogen (serpin peptidase inhibitor, clade A, member 8); ANHU; fetal-liver predominant transporter 1; FLJ92595; FLJ97926; hFLT1; pre-angiotensinogen; serine (or cysteine) proteinase inhibitor; serpin A8; serpin peptidase inhibitor, clade A, member 8; SERPINA8
Orthologs:
Mus musculus (house mouse) : Agt (angiotensinogen (serpin peptidase inhibitor, clade A, member 8))  MGI  Alliance
Rattus norvegicus (Norway rat) : Agt (angiotensinogen)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Agt (angiotensinogen)
Pan paniscus (bonobo/pygmy chimpanzee) : AGT (angiotensinogen)
Canis lupus familiaris (dog) : AGT (angiotensinogen)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Agt (angiotensinogen)
Sus scrofa (pig) : AGT (angiotensinogen)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381230,702,523 - 230,714,122 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371230,838,269 - 230,850,336 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361228,904,892 - 228,916,564 (-)NCBINCBI36hg18NCBI36
Build 341227,145,019 - 227,156,602NCBI
Celera1204,104,291 - 204,116,358 (-)NCBI
Cytogenetic Map1q42.2NCBI
HuRef1201,323,209 - 201,335,277 (-)NCBIHuRef
CHM1_11232,111,282 - 232,123,349 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Protein Structures
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on AGT
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731070
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.