AGT (angiotensinogen) - Rat Genome Database

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Gene: AGT (angiotensinogen) Homo sapiens
Symbol: AGT
Name: angiotensinogen
RGD ID: 731070
HGNC Page HGNC:333
Description: Enables angiotensin receptor binding activity; receptor ligand activity; and sodium channel regulator activity. Involved in several processes, including positive regulation of peptidyl-tyrosine phosphorylation; regulation of gene expression; and regulation of signal transduction. Located in extracellular space. Part of collagen-containing extracellular matrix. Implicated in several diseases, including Fabry disease; Henoch-Schoenlein purpura; artery disease (multiple); heart conduction disease (multiple); and hydronephrosis. Biomarker of several diseases, including alcoholic hepatitis; chronic myeloid leukemia; intermediate coronary syndrome; systemic scleroderma (multiple); and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: alpha-1 antiproteinase, antitrypsin; angiotensin I; angiotensin II; angiotensinogen (serine (or cysteine) proteinase inhibitor, clade a (alpha-1 antiproteinase, antitrypsin), member 8); angiotensinogen (serpin peptidase inhibitor, clade A, member 8); ANHU; fetal-liver predominant transporter 1; FLJ92595; FLJ97926; hFLT1; pre-angiotensinogen; serine (or cysteine) proteinase inhibitor; serpin A8; serpin peptidase inhibitor, clade A, member 8; SERPINA8
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is relevant for disease process.
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381230,702,523 - 230,745,583 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1230,690,776 - 230,745,576 (-)EnsemblGRCh38hg38GRCh38
GRCh371230,838,269 - 230,881,329 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361228,904,892 - 228,916,564 (-)NCBINCBI36Build 36hg18NCBI36
Build 341227,145,019 - 227,156,602NCBI
Celera1204,104,291 - 204,116,358 (-)NCBICelera
Cytogenetic Map1q42.2NCBI
HuRef1201,323,209 - 201,335,277 (-)NCBIHuRef
CHM1_11232,111,282 - 232,123,349 (-)NCBICHM1_1
T2T-CHM13v2.01230,083,077 - 230,126,137 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (EXP)
Albuminuria  (EXP,IEA)
alcoholic cardiomyopathy  (EXP)
alcoholic hepatitis  (IEP)
Alkalosis  (EXP)
allergic disease  (IAGP)
Alzheimer's disease  (IEP)
Anaphylaxis  (IEP)
anemia  (EXP)
anti-basement membrane glomerulonephritis  (ISO)
anuria  (EXP)
aortic aneurysm  (EXP)
Aortic Calcification  (ISO)
Aortic Coarctation  (IAGP)
atherosclerosis  (EXP,ISO)
atrial fibrillation  (IAGP)
bipolar disorder  (IEA)
Bradycardia  (EXP)
breast cancer  (IAGP,IEP)
Cardiac Arrhythmias  (EXP)
Cardiomegaly  (EXP,ISO)
cardiomyopathy  (EXP)
Cardiotoxicity  (EXP)
Cardiovascular Abnormalities  (EXP)
cardiovascular system disease  (EXP,IAGP,IEA)
carotid artery disease  (EXP,IAGP)
Catalepsy  (EXP)
cerebrovascular disease  (IAGP)
Chemical and Drug Induced Liver Injury  (EXP)
cholestasis  (EXP)
Chronic Intermittent Hypoxia  (ISO)
chronic myeloid leukemia  (IEP)
cleidocranial dysplasia  (IAGP)
cognitive disorder  (EXP)
congestive heart failure  (EXP,IAGP,IEP,ISO)
corneal neovascularization  (ISO)
coronary artery disease  (IEA)
Crohn's disease  (IAGP)
Diabetic Cardiomyopathies  (EXP)
Diabetic Nephropathies  (EXP,IAGP,IEA)
diabetic retinopathy  (EXP,IAGP,ISO)
Diaphragmatic Hernia  (EXP)
diffuse scleroderma  (IEP)
dilated cardiomyopathy  (IAGP,ISO)
Dissecting Aneurysm  (EXP)
Drug Overdose  (EXP)
end stage renal disease  (IEA)
endomyocardial fibrosis  (EXP)
essential hypertension  (IAGP)
Experimental Diabetes Mellitus  (EXP)
Experimental Liver Cirrhosis  (EXP)
Experimental Mammary Neoplasms  (IDA)
Fabry disease  (IAGP)
Fetal Growth Retardation  (EXP,IMP,ISO)
Fibrosis  (EXP,ISO)
focal segmental glomerulosclerosis  (EXP,ISO)
gastric ulcer  (ISO)
gastrointestinal stromal tumor  (IAGP)
glomerulonephritis  (EXP,ISO)
glucose intolerance  (EXP)
heart disease  (EXP)
Hemorrhage  (IAGP)
Henoch-Schoenlein purpura  (IAGP)
hydronephrosis  (IMP,ISO)
Hyperalgesia  (EXP)
Hyperemia  (EXP)
hyperhomocysteinemia  (EXP)
hyperinsulinism  (IAGP)
hypertension  (EXP,IAGP,IEA,ISO)
Hypertensive Nephropathy  (ISO)
hypertrophic cardiomyopathy  (IAGP)
Hypertrophy  (EXP)
hypokalemia  (EXP)
Hypotension  (EXP,ISO)
IgA glomerulonephritis  (EXP,IAGP)
impotence  (ISO)
Inflammation  (EXP)
inflammatory bowel disease  (IAGP)
intermediate coronary syndrome  (IEP)
Intestinal Reperfusion Injury  (ISO)
kidney disease  (EXP)
kidney failure  (EXP)
Left Ventricular Hypertrophy  (EXP)
liver cirrhosis  (EXP,ISO)
malignant hypertension  (EXP)
meconium aspiration syndrome  (ISO)
Metabolic Syndrome  (ISO)
microcephaly  (IAGP)
middle cerebral artery infarction  (ISO)
mitral valve prolapse  (IAGP,IEA)
multiple sclerosis  (IEP)
myocardial infarction  (EXP,IAGP,IEA,ISO)
Myocardial Ischemia  (EXP)
Myocardial Reperfusion Injury  (EXP)
Necrosis  (EXP)
Neointima  (EXP)
nephrosis  (EXP)
Neurobehavioral Manifestations  (EXP)
obesity  (IAGP)
oligohydramnios  (IAGP)
otosclerosis  (IAGP)
parathyroid carcinoma  (IAGP)
Peptic Ulcer Hemorrhage  (EXP)
pneumonia  (EXP)
polycystic kidney disease  (ISO)
pre-eclampsia  (EXP,IAGP,IMP)
prediabetes syndrome  (ISO)
Pregnancy-Induced Hypertension  (ISO)
primary biliary cholangitis  (ISO)
proteinuria  (EXP)
pulmonary edema  (IAGP)
pulmonary fibrosis  (EXP,ISO)
pulmonary hypertension  (ISO)
Puromycin Aminonucleoside Nephrosis  (ISO)
renal hypertension  (EXP)
Renal Tubular Dysgenesis  (EXP,IAGP)
Reperfusion Injury  (EXP)
retinal vasculitis  (ISO)
retinopathy of prematurity  (EXP)
sciatic neuropathy  (ISO)
sick sinus syndrome  (IAGP)
skin melanoma  (IEP)
Stroke  (IAGP,IEA)
Sudden Death  (EXP)
systemic scleroderma  (IEP)
temporal lobe epilepsy  (ISO)
thrombosis  (EXP)
transient cerebral ischemia  (ISO)
type 2 diabetes mellitus  (IAGP,IEP)
ureteral obstruction  (EXP)
vascular disease  (EXP)
Vascular Malformations  (IEP)
Vascular Remodeling  (EXP)
Ventricular Dysfunction, Left  (EXP)
Ventricular Remodeling  (EXP)
visual epilepsy  (EXP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(+)-taxifolin  (ISO)
(R)-lipoic acid  (ISO)
(R)-mevalonic acid  (ISO)
(R)-noradrenaline  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-amphetamine  (ISO)
1,2-dichloroethane  (ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (ISO)
11-deoxycorticosterone  (ISO)
11-Hydroxyandrostenedione  (EXP)
14,15-EET  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2,6-dinitrotoluene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
3',5'-cyclic GMP  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (EXP)
3,7-dihydropurine-6-thione  (ISO)
3-[3-acetyl-4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl]-1,1-diethylurea  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-Hydroperoxy-2-nonenal  (EXP)
4-hydroperoxycyclophosphamide  (EXP)
4-hydroxy-TEMPO  (ISO)
4-hydroxynon-2-enal  (EXP)
4-phenylbutyric acid  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-oxoprostaglandin F1alpha  (ISO)
6-propyl-2-thiouracil  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP,ISO)
8-Br-cAMP  (EXP)
8-hydroxy-2'-deoxyguanosine  (EXP)
Ac-Ser-Asp-Lys-Pro-OH  (EXP,ISO)
acadesine  (ISO)
acetamide  (ISO)
acetylcholine  (ISO)
acetylsalicylic acid  (EXP)
actinomycin D  (EXP,ISO)
adefovir  (ISO)
Adenosine, cyclic 3',5'-[hydrogen [p(s)]-phosphorothioate]  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (EXP,ISO)
aliskiren  (ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (ISO)
alpha-cyano-4-hydroxycinnamic acid  (ISO)
amidotrizoic acid  (ISO)
amiloride  (EXP,ISO)
amiodarone  (EXP,ISO)
amitrole  (ISO)
amlodipine  (EXP)
ammonia  (ISO)
ammonium chloride  (ISO)
angiotensin II  (EXP,ISO)
apocynin  (EXP,ISO)
arachidonic acid  (ISO)
aristolochic acid A  (EXP)
arsenite(3-)  (ISO)
aspartame  (EXP)
astressin  (ISO)
atenolol  (EXP)
atorvastatin calcium  (ISO)
azoxystrobin  (ISO)
bafilomycin A1  (ISO)
benazepril  (EXP,ISO)
benidipine  (EXP)
benzbromarone  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-D-glucosamine  (ISO)
beta-endorphin  (ISO)
biopterin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol F  (ISO)
boric acid  (ISO)
BQ 123  (ISO)
brefeldin A  (ISO)
brimonidine tartrate  (ISO)
Brodifacoum  (ISO)
butan-1-ol  (EXP,ISO)
butanal  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calciol  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
candesartan  (EXP,ISO)
Candesartan cilexetil  (EXP,ISO)
captopril  (EXP,ISO)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
carmustine  (EXP)
carvedilol  (EXP,ISO)
CGP-42112A  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
chromium atom  (ISO)
chymostatin  (EXP,ISO)
ciglitazone  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
clofibric acid  (ISO)
clozapine  (EXP)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP)
corticosterone  (EXP)
cortisol  (EXP)
Cuprizon  (ISO)
curcumin  (ISO)
cyclosporin A  (EXP,ISO)
cypermethrin  (ISO)
D-glucose  (EXP,ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
dibenziodolium  (ISO)
diethyl malate  (ISO)
diminazene diaceturate  (EXP,ISO)
dioxygen  (ISO)
disodium cromoglycate  (ISO)
diuron  (ISO)
dopamine  (EXP)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
doxycycline  (ISO)
EC (peptidyl-dipeptidase A) inhibitor  (EXP,ISO)
efonidipine hydrochloride  (EXP)
elcometrine  (EXP)
emodin  (ISO)
enalapril  (EXP,ISO)
enalaprilat dihydrate  (EXP,ISO)
endosulfan  (ISO)
eplerenone  (ISO)
ergosta-4,6,8(14),22-tetraen-3-one  (EXP,ISO)
ethanol  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
famotidine  (ISO)
fenofibrate  (ISO)
flavonoids  (EXP)
flutamide  (ISO)
folic acid  (ISO)
fosinopril  (ISO)
fructose  (ISO)
fulvestrant  (EXP,ISO)
fumonisin B1  (EXP,ISO)
furan  (ISO)
furosemide  (EXP)
genistein  (EXP)
gentamycin  (ISO)
Ginkgoic acid  (ISO)
glucose  (EXP,ISO)
glutathione  (EXP,ISO)
glutathione disulfide  (ISO)
glycerol  (ISO)
glycochenodeoxycholic acid  (ISO)
glyphosate  (ISO)
goralatide  (EXP,ISO)
heparin  (ISO)
hydralazine  (ISO)
hydrazines  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (EXP)
ibuprofen  (ISO)
ICI 118551  (ISO)
Ile(5)-angiotensin II  (EXP,ISO)
imidacloprid  (ISO)
imidaprilat  (ISO)
imperatorin  (ISO)
indometacin  (EXP,ISO)
iohexol  (ISO)
irbesartan  (EXP,ISO)
irinotecan  (EXP)
isoprenaline  (EXP,ISO)
isorhamnetin  (ISO)
Isorhapontigenin  (ISO)
ketamine  (EXP,ISO)
L-ascorbic acid  (EXP,ISO)
L-ethionine  (ISO)
labetalol  (EXP)
lactacystin  (ISO)
lead(0)  (EXP,ISO)
lead(2+)  (EXP,ISO)
levonorgestrel  (EXP)
linoleic acid hydroperoxide  (EXP)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lipoxin A4  (ISO)
lisinopril dihydrate  (EXP,ISO)
losartan  (EXP,ISO)
LY294002  (ISO)
Magnolol  (ISO)
malonaldehyde  (EXP,ISO)
mangiferin  (ISO)
melatonin  (ISO)
mercaptopurine  (ISO)
mercury dichloride  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
methimazole  (ISO)
methotrexate  (ISO)
methylglyoxal  (ISO)
Mibefradil  (EXP)
microcystin RR  (ISO)
midostaurin  (ISO)
miquelianin  (EXP)
mithramycin  (ISO)
MK-2206  (EXP)
monocrotaline  (ISO)
montelukast  (EXP)
mycophenolic acid  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-desethylamiodarone  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methylnicotinate  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
naloxone  (ISO)
naringin  (EXP)
nebivolol  (ISO)
Neferine  (EXP)
nerolidol  (ISO)
nickel atom  (EXP)
nicorandil  (ISO)
nicotinic acid  (EXP,ISO)
nimesulide  (ISO)
nitric oxide  (EXP,ISO)
nitrites  (ISO)
nitrofen  (ISO)
nitrofurantoin  (ISO)
nitroprusside  (ISO)
NS-398  (ISO)
O-methyleugenol  (EXP)
ochratoxin A  (ISO)
okadaic acid  (ISO)
olmesartan  (EXP,ISO)
oltipraz  (ISO)
omeprazole  (ISO)
ouabain  (ISO)
ozone  (ISO)
Pachymic acid  (EXP,ISO)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
parathion  (ISO)
PD 168393  (ISO)
PD123319  (EXP,ISO)
perfluorooctanoic acid  (EXP)
perindopril  (EXP,ISO)
peroxynitrous acid  (ISO)
phenylarsine oxide  (ISO)
phenylephrine  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidic acid  (ISO)
phosphoramidon  (ISO)
pindolol  (EXP)
pioglitazone  (ISO)
pirinixic acid  (ISO)
potassium atom  (EXP)
potassium dichromate  (ISO)
pravastatin  (ISO)
pregabalin  (ISO)
probenecid  (ISO)
progesterone  (EXP,ISO)
propanal  (EXP)
propranolol  (EXP,ISO)
prostaglandin E1  (EXP)
prostaglandin E2  (ISO)
prostaglandin I2  (ISO)
prostaglandins E  (ISO)
purine-6-thiol  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP,ISO)
quinacrine  (ISO)
quinapril hydrochloride  (ISO)
raloxifene  (EXP)
reactive oxygen species  (EXP,ISO)
reboxetine  (EXP)
resveratrol  (EXP,ISO)
rotenone  (EXP,ISO)
rottlerin  (ISO)
rutin  (ISO)
salubrinal  (ISO)
saralasin  (ISO)
SB 203580  (ISO)
scopolamine  (EXP)
sevoflurane  (ISO)
sildenafil citrate  (EXP,ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium atom  (EXP,ISO)
sodium chloride  (EXP,ISO)
Soman  (ISO)
spironolactone  (EXP,ISO)
streptozocin  (ISO)
succimer  (EXP)
sucrose  (ISO)
sulforaphane  (ISO)
sunitinib  (EXP)
superoxide  (EXP,ISO)
tamibarotene  (ISO)
tamoxifen  (EXP)
taurine  (ISO)
taurolithocholic acid sulfate  (ISO)
tauroursodeoxycholic acid  (ISO)
telmisartan  (ISO)
temozolomide  (EXP)
testosterone  (ISO)
Testosterone propionate  (ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
thiabendazole  (ISO)
thioacetamide  (ISO)
thiopental  (EXP)
Thiorphan  (EXP,ISO)
Tiron  (EXP,ISO)
titanium dioxide  (EXP,ISO)
torasemide  (ISO)
trandolapril  (ISO)
trans-piceid  (ISO)
tributylstannane  (ISO)
trichloroethene  (ISO)
triclosan  (EXP)
troglitazone  (EXP)
tyrphostin AG 1478  (ISO)
U-73122  (ISO)
valproic acid  (EXP,ISO)
valsartan  (EXP,ISO)
Vinpocetine  (ISO)
vismodegib  (EXP)
wortmannin  (ISO)
xestospongin C  (ISO)
zaragozic acid A  (ISO)
zinc atom  (EXP,ISO)
zinc protoporphyrin  (EXP)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of NF-kappaB-inducing kinase activity  (ISO)
activation of phospholipase C activity  (IEA,ISO)
aging  (IEA,ISO)
aldosterone secretion  (ISO)
angiotensin-activated signaling pathway  (IDA)
angiotensin-mediated drinking behavior  (IEA,ISO)
angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure  (ISO)
artery smooth muscle contraction  (IEA,ISO)
associative learning  (IEA,ISO)
astrocyte activation  (ISO)
blood vessel development  (ISO)
blood vessel diameter maintenance  (IEA)
blood vessel remodeling  (TAS)
brain renin-angiotensin system  (ISO)
branching involved in ureteric bud morphogenesis  (ISO)
cell growth involved in cardiac muscle cell development  (IEA,ISO)
cell population proliferation  (ISO)
cell surface receptor signaling pathway  (IEA,ISO)
cell-cell signaling  (TAS)
cell-matrix adhesion  (ISO)
cellular response to angiotensin  (IEA,ISO)
cellular response to mechanical stimulus  (IEA,ISO)
cytokine production  (ISO)
drinking behavior  (ISO)
ERK1 and ERK2 cascade  (IEA,ISO)
establishment of blood-nerve barrier  (ISO)
extracellular matrix organization  (ISO)
female pregnancy  (IEA,ISO)
fibroblast proliferation  (IEA,ISO)
G protein-coupled receptor signaling pathway  (IDA,IEA,ISO)
G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger  (TAS)
hormone metabolic process  (ISO)
intracellular sodium ion homeostasis  (IEA,ISO)
kidney development  (IMP,ISO)
low-density lipoprotein particle remodeling  (NAS)
maintenance of blood vessel diameter homeostasis by renin-angiotensin  (TAS)
MAPK cascade  (ISO)
negative regulation of angiogenesis  (IEA,ISO)
negative regulation of cell growth  (IEA,ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of endopeptidase activity  (IBA,IEA)
negative regulation of gene expression  (IDA)
negative regulation of MAP kinase activity  (IMP)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of neurotrophin TRK receptor signaling pathway  (IDA)
negative regulation of smooth muscle cell proliferation  (ISO)
negative regulation of sodium ion transmembrane transporter activity  (TAS)
negative regulation of tissue remodeling  (IEA,ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
neuron apoptotic process  (ISO)
nitric oxide mediated signal transduction  (TAS)
obsolete positive regulation of cholesterol esterification  (IDA)
operant conditioning  (IEA,ISO)
organ growth  (ISO)
ovarian follicle rupture  (ISO)
peristalsis  (ISO)
phospholipase C-activating G protein-coupled receptor signaling pathway  (NAS)
positive regulation of activation of Janus kinase activity  (IMP)
positive regulation of blood pressure  (IEA,ISO)
positive regulation of branching involved in ureteric bud morphogenesis  (IDA)
positive regulation of cardiac muscle cell apoptotic process  (IEA,ISO)
positive regulation of cardiac muscle hypertrophy  (IEA,ISS)
positive regulation of catalytic activity  (IEA,ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of CoA-transferase activity  (IDA)
positive regulation of cytokine production  (TAS)
positive regulation of cytosolic calcium ion concentration  (IEA,ISO)
positive regulation of DNA-templated transcription  (IDA)
positive regulation of endothelial cell migration  (IDA)
positive regulation of epidermal growth factor receptor signaling pathway  (IDA)
positive regulation of extracellular matrix constituent secretion  (IEA,ISO)
positive regulation of extrinsic apoptotic signaling pathway  (IDA)
positive regulation of fatty acid biosynthetic process  (ISO)
positive regulation of fibroblast proliferation  (IEA,ISS)
positive regulation of gap junction assembly  (IGI)
positive regulation of gene expression  (ISO)
positive regulation of inflammatory response  (TAS)
positive regulation of insulin receptor signaling pathway  (IEA,ISO)
positive regulation of L-arginine import across plasma membrane  (IEA,ISO)
positive regulation of L-lysine import across plasma membrane  (IEA,ISO)
positive regulation of macrophage derived foam cell differentiation  (IC,IDA)
positive regulation of MAPK cascade  (ISO)
positive regulation of membrane hyperpolarization  (IMP)
positive regulation of multicellular organism growth  (ISO)
positive regulation of NAD(P)H oxidase activity  (TAS)
positive regulation of neuron projection development  (IEA,ISO)
positive regulation of NF-kappaB transcription factor activity  (TAS)
positive regulation of nitric oxide biosynthetic process  (IEA,ISO)
positive regulation of organ growth  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (IDA)
positive regulation of phosphatidylinositol 3-kinase signaling  (IDA)
positive regulation of protein kinase C activity  (ISO)
positive regulation of protein metabolic process  (IDA)
positive regulation of protein tyrosine kinase activity  (IMP)
positive regulation of reactive oxygen species metabolic process  (TAS)
positive regulation of renal sodium excretion  (IEA,ISO)
positive regulation of superoxide anion generation  (IEA,ISO)
positive regulation of vascular associated smooth muscle cell migration  (IEA,ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (IEA,ISO)
protein import into nucleus  (IEA,ISO)
regulation of apoptotic process  (IBA,IEA,ISO)
regulation of blood pressure  (IGI,ISO)
regulation of blood volume by renin-angiotensin  (NAS)
regulation of calcium ion transport  (IEA,ISO)
regulation of cardiac conduction  (IGI)
regulation of cell growth  (NAS)
regulation of cell population proliferation  (NAS)
regulation of extracellular matrix assembly  (IGI)
regulation of gene expression  (ISO)
regulation of heart rate  (IEA,ISO)
regulation of inflammatory response  (ISO)
regulation of long-term neuronal synaptic plasticity  (IEA,ISO)
regulation of norepinephrine secretion  (IEA,ISO)
regulation of renal output by angiotensin  (ISO,NAS)
regulation of renal sodium excretion  (IEA,ISO,NAS)
regulation of systemic arterial blood pressure by circulatory renin-angiotensin  (ISO)
regulation of systemic arterial blood pressure by renin-angiotensin  (IEA)
regulation of transmission of nerve impulse  (IEA,ISO)
regulation of vasoconstriction  (NAS)
renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure  (ISO)
renal system process  (IDA)
renin-angiotensin regulation of aldosterone production  (IEA,ISO,NAS)
response to cold  (ISO)
response to estradiol  (IEA,ISO)
response to muscle activity involved in regulation of muscle adaptation  (IEA,ISS)
response to salt stress  (ISO)
smooth muscle cell differentiation  (ISO)
smooth muscle cell proliferation  (IEA,ISO)
stress-activated MAPK cascade  (IEA,ISO)
uterine smooth muscle contraction  (IEA,ISO)
vascular associated smooth muscle cell proliferation  (ISO)
vasoconstriction  (IEA,ISO)
vasodilation  (IEA,ISO)
vasopressin secretion  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype