AGT (angiotensinogen) - Rat Genome Database

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Gene: AGT (angiotensinogen) Homo sapiens
Analyze
Symbol: AGT
Name: angiotensinogen
RGD ID: 731070
HGNC Page HGNC:333
Description: Enables angiotensin receptor binding activity; hormone activity; and sodium channel regulator activity. Involved in several processes, including positive regulation of branching involved in ureteric bud morphogenesis; regulation of gene expression; and regulation of signal transduction. Located in blood microparticle; collagen-containing extracellular matrix; and extracellular exosome. Is active in extracellular space. Implicated in several diseases, including Fabry disease; Henoch-Schoenlein purpura; artery disease (multiple); heart conduction disease (multiple); and hydronephrosis. Biomarker of several diseases, including alcoholic hepatitis; chronic myeloid leukemia; intermediate coronary syndrome; systemic scleroderma (multiple); and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: alpha-1 antiproteinase, antitrypsin; angiotensin I; angiotensin II; angiotensinogen (serine (or cysteine) proteinase inhibitor, clade a (alpha-1 antiproteinase, antitrypsin), member 8); angiotensinogen (serpin peptidase inhibitor, clade A, member 8); ANHU; fetal-liver predominant transporter 1; FLJ92595; FLJ97926; hFLT1; pre-angiotensinogen; serine (or cysteine) proteinase inhibitor; serpin A8; serpin peptidase inhibitor, clade A, member 8; SERPINA8
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is relevant for disease process.
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381230,702,523 - 230,745,583 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1230,690,776 - 230,745,576 (-)EnsemblGRCh38hg38GRCh38
GRCh371230,838,269 - 230,881,329 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361228,904,892 - 228,916,564 (-)NCBINCBI36Build 36hg18NCBI36
Build 341227,145,019 - 227,156,602NCBI
Celera1204,104,291 - 204,116,358 (-)NCBICelera
Cytogenetic Map1q42.2NCBI
HuRef1201,323,209 - 201,335,277 (-)NCBIHuRef
CHM1_11232,111,282 - 232,123,349 (-)NCBICHM1_1
T2T-CHM13v2.01230,083,077 - 230,126,137 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (EXP)
Actin-Accumulation Myopathy  (IAGP)
Albuminuria  (EXP,IEA)
alcoholic cardiomyopathy  (EXP)
alcoholic hepatitis  (IEP)
Alkalosis  (EXP)
allergic disease  (IAGP)
Alzheimer's disease  (IEP)
Anaphylaxis  (IEP)
anemia  (EXP)
anti-basement membrane glomerulonephritis  (ISO)
anuria  (EXP)
aortic aneurysm  (EXP)
Aortic Calcification  (ISO)
Aortic Coarctation  (IAGP)
atherosclerosis  (EXP,ISO)
atrial fibrillation  (IAGP)
bipolar disorder  (IEA)
Bradycardia  (EXP)
breast cancer  (IAGP,IEP)
Cardiac Arrhythmias  (EXP)
Cardiomegaly  (EXP,ISO)
cardiomyopathy  (EXP)
Cardiotoxicity  (EXP)
Cardiovascular Abnormalities  (EXP)
cardiovascular system disease  (EXP,IAGP,IEA)
carotid artery disease  (EXP,IAGP)
Catalepsy  (EXP)
cerebrovascular disease  (IAGP)
Chemical and Drug Induced Liver Injury  (EXP)
cholestasis  (EXP)
Chronic Intermittent Hypoxia  (ISO)
chronic myeloid leukemia  (IEP)
cleidocranial dysplasia  (IAGP)
cognitive disorder  (EXP)
congenital disorder of glycosylation type IIq  (IAGP)
congestive heart failure  (EXP,IAGP,IEP,ISO)
corneal neovascularization  (ISO)
coronary artery disease  (IEA)
COVID-19  (EXP)
Crohn's disease  (IAGP)
Diabetic Cardiomyopathies  (EXP)
Diabetic Nephropathies  (EXP,IAGP,IEA)
diabetic retinopathy  (EXP,IAGP,ISO)
Diaphragmatic Hernia  (EXP)
diffuse scleroderma  (IEP)
dilated cardiomyopathy  (IAGP,ISO)
Dissecting Aneurysm  (EXP)
Drug Overdose  (EXP)
end stage renal disease  (IEA)
endomyocardial fibrosis  (EXP)
essential hypertension  (EXP,IAGP)
Experimental Diabetes Mellitus  (EXP)
Experimental Liver Cirrhosis  (EXP)
Experimental Mammary Neoplasms  (IDA)
Fabry disease  (IAGP)
Fetal Growth Retardation  (EXP,IMP,ISO)
Fibrosis  (EXP,ISO)
focal segmental glomerulosclerosis  (EXP,ISO)
gastric ulcer  (ISO)
gastrointestinal stromal tumor  (IAGP)
genetic disease  (IAGP)
glomerulonephritis  (EXP,ISO)
glucose intolerance  (EXP)
heart disease  (EXP)
Hemorrhage  (IAGP)
Henoch-Schoenlein purpura  (IAGP)
hydronephrosis  (IMP,ISO)
Hyperalgesia  (EXP)
Hyperemia  (EXP)
hyperhomocysteinemia  (EXP)
hyperinsulinism  (IAGP)
hypertension  (EXP,IAGP,IEA,ISO)
Hypertensive Nephropathy  (ISO)
hypertrophic cardiomyopathy  (IAGP)
Hypertrophy  (EXP)
hypokalemia  (EXP)
Hypotension  (EXP,ISO)
IgA glomerulonephritis  (EXP,IAGP)
impotence  (ISO)
Inflammation  (EXP)
inflammatory bowel disease  (IAGP)
intermediate coronary syndrome  (IEP)
Intestinal Reperfusion Injury  (ISO)
kidney disease  (EXP)
kidney failure  (EXP)
Left Ventricular Hypertrophy  (EXP)
liver cirrhosis  (EXP,ISO)
malignant hypertension  (EXP)
meconium aspiration syndrome  (ISO)
Metabolic Syndrome  (ISO)
microcephaly  (IAGP)
middle cerebral artery infarction  (ISO)
mitral valve prolapse  (IAGP,IEA)
multiple sclerosis  (IEP)
myocardial infarction  (EXP,IAGP,IEA,ISO)
Myocardial Ischemia  (EXP)
Myocardial Reperfusion Injury  (EXP)
Necrosis  (EXP)
Neointima  (EXP)
nephrosis  (EXP)
Neurobehavioral Manifestations  (EXP)
obesity  (IAGP)
oligohydramnios  (IAGP)
otosclerosis  (IAGP)
parathyroid carcinoma  (IAGP)
Peptic Ulcer Hemorrhage  (EXP)
pneumonia  (EXP)
polycystic kidney disease  (ISO)
pre-eclampsia  (EXP,IAGP,IMP)
prediabetes syndrome  (ISO)
Pregnancy-Induced Hypertension  (ISO)
Prenatal Exposure Delayed Effects  (ISO)
primary biliary cholangitis  (ISO)
proteinuria  (EXP)
pulmonary edema  (IAGP)
pulmonary fibrosis  (EXP,ISO)
pulmonary hypertension  (ISO)
Puromycin Aminonucleoside Nephrosis  (ISO)
renal hypertension  (EXP)
Renal Tubular Dysgenesis  (EXP,IAGP)
Reperfusion Injury  (EXP)
retinal vasculitis  (ISO)
retinopathy of prematurity  (EXP)
sciatic neuropathy  (ISO)
sick sinus syndrome  (IAGP)
skin melanoma  (IEP)
Stroke  (IAGP,IEA)
Sudden Death  (EXP)
systemic scleroderma  (IEP)
temporal lobe epilepsy  (ISO)
thrombosis  (EXP)
transient cerebral ischemia  (ISO)
type 2 diabetes mellitus  (IAGP,IEP)
ureteral obstruction  (EXP)
vascular disease  (EXP)
Vascular Malformations  (IEP)
Vascular Remodeling  (EXP)
Ventricular Dysfunction, Left  (EXP)
Ventricular Remodeling  (EXP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(+)-taxifolin  (ISO)
(1->4)-beta-D-glucan  (ISO)
(R)-lipoic acid  (ISO)
(R)-noradrenaline  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-amphetamine  (ISO)
1,2-dichloroethane  (ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (ISO)
11-deoxycorticosterone  (ISO)
11-Hydroxyandrostenedione  (EXP)
14,15-EET  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2,6-dinitrotoluene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
3',5'-cyclic GMP  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (EXP)
3,7-dihydropurine-6-thione  (ISO)
3-[3-acetyl-4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl]-1,1-diethylurea  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-Hydroperoxy-2-nonenal  (EXP)
4-hydroperoxycyclophosphamide  (EXP)
4-hydroxy-TEMPO  (ISO)
4-hydroxynon-2-enal  (EXP)
4-phenylbutyric acid  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-oxoprostaglandin F1alpha  (ISO)
6-propyl-2-thiouracil  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP,ISO)
8-Br-cAMP  (EXP)
8-hydroxy-2'-deoxyguanosine  (EXP)
AACOCF3  (ISO)
Ac-Ser-Asp-Lys-Pro-OH  (EXP,ISO)
acadesine  (ISO)
acetamide  (ISO)
acetylcholine  (ISO)
acetylsalicylic acid  (EXP)
actinomycin D  (EXP,ISO)
adefovir  (ISO)
Adenosine, cyclic 3',5'-[hydrogen [p(s)]-phosphorothioate]  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (EXP,ISO)
aliskiren  (ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (ISO)
alpha-cyano-4-hydroxycinnamic acid  (ISO)
alpha-Zearalanol  (ISO)
amidotrizoic acid  (ISO)
amiloride  (EXP,ISO)
amiodarone  (EXP,ISO)
amitrole  (ISO)
amlodipine  (EXP)
ammonia  (ISO)
ammonium chloride  (ISO)
angiotensin II  (EXP,ISO)
ANTIMYCIN  (ISO)
apocynin  (EXP,ISO)
arachidonic acid  (ISO)
aristolochic acid A  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
aspartame  (EXP)
astressin  (ISO)
atenolol  (EXP)
atorvastatin calcium  (ISO)
azoxystrobin  (ISO)
bafilomycin A1  (ISO)
BAPTA  (ISO)
benazepril  (EXP,ISO)
benidipine  (EXP)
benzbromarone  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-D-glucosamine  (ISO)
beta-endorphin  (ISO)
biopterin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol F  (ISO)
boric acid  (ISO)
BQ 123  (ISO)
brefeldin A  (ISO)
brimonidine tartrate  (ISO)
Brodifacoum  (ISO)
bucladesine  (EXP)
butan-1-ol  (EXP,ISO)
butanal  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calciol  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
Calphostin C  (ISO)
candesartan  (EXP,ISO)
Candesartan cilexetil  (EXP,ISO)
captopril  (EXP,ISO)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
carmustine  (EXP)
carvedilol  (EXP,ISO)
CCCP  (ISO)
CGP-42112A  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
chromium atom  (ISO)
chymostatin  (EXP,ISO)
ciglitazone  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
clofibric acid  (ISO)
clozapine  (EXP)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP)
cordycepin  (EXP)
corticosterone  (EXP)
cortisol  (EXP)
crotonaldehyde  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cyclosporin A  (EXP,ISO)
cypermethrin  (ISO)
D-glucose  (EXP,ISO)
DDE  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
dibenziodolium  (ISO)
diethyl malate  (ISO)
diminazene diaceturate  (EXP,ISO)
dioxygen  (ISO)
diquat  (ISO)
disodium cromoglycate  (ISO)
diuron  (ISO)
dopamine  (EXP)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
doxycycline  (ISO)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (EXP,ISO)
efonidipine hydrochloride  (EXP)
elcometrine  (EXP)
emodin  (ISO)
enalapril  (EXP,ISO)
enalaprilat dihydrate  (EXP,ISO)
endosulfan  (ISO)
eplerenone  (ISO)
ergosta-4,6,8(14),22-tetraen-3-one  (EXP,ISO)
ethanol  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
famotidine  (ISO)
fenofibrate  (ISO)
flavonoids  (EXP)
flutamide  (ISO)
folic acid  (ISO)
fosinopril  (ISO)
fructose  (ISO)
fulvestrant  (EXP,ISO)
fumonisin B1  (EXP,ISO)
furan  (ISO)
furosemide  (EXP)
genistein  (EXP)
gentamycin  (ISO)
Ginkgoic acid  (ISO)
glucose  (EXP,ISO)
glutathione  (EXP,ISO)
glutathione disulfide  (ISO)
glycerol  (ISO)
glycochenodeoxycholic acid  (ISO)
glyphosate  (ISO)
goralatide  (EXP,ISO)
Harpagide  (ISO)
heparin  (ISO)
hydralazine  (ISO)
hydrazines  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (EXP)
ibuprofen  (ISO)
icatibant  (ISO)
ICI 118551  (ISO)
Ile(5)-angiotensin II  (EXP,ISO)
imidacloprid  (ISO)
imidaprilat  (ISO)
imperatorin  (ISO)
indometacin  (EXP,ISO)
iohexol  (ISO)
irbesartan  (EXP,ISO)
irinotecan  (EXP)
isoprenaline  (EXP,ISO)
isorhamnetin  (ISO)
Isorhapontigenin  (ISO)
ketamine  (EXP,ISO)
ketoconazole  (ISO)
L-ascorbic acid  (EXP,ISO)
L-erythro-biopterin  (ISO)
L-ethionine  (ISO)
labetalol  (EXP)
lactacystin  (ISO)
lead(0)  (EXP,ISO)
levonorgestrel  (EXP)
linoleic acid hydroperoxide  (EXP)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lipoxin A4  (ISO)
lisinopril dihydrate  (EXP,ISO)
losartan  (EXP,ISO)
LY294002  (ISO)
Magnolol  (ISO)
malonaldehyde  (EXP,ISO)
mangiferin  (ISO)
medroxyprogesterone acetate  (EXP)
melatonin  (ISO)
mercaptopurine  (ISO)
mercury dichloride  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
methimazole  (ISO)
methotrexate  (ISO)
methylglyoxal  (ISO)
mevalonic acid  (ISO)
Mibefradil  (EXP)
microcystin RR  (ISO)
midostaurin  (ISO)
miquelianin  (EXP)
mithramycin  (ISO)
MK-2206  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (ISO)
montelukast  (EXP)
mycophenolic acid  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-desethylamiodarone  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methylnicotinate  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
naloxone  (ISO)
naringin  (EXP)
nebivolol  (ISO)
Neferine  (EXP)
nerolidol  (ISO)
nickel atom  (EXP)
nicorandil  (ISO)
nicotinic acid  (EXP,ISO)
nimesulide  (ISO)
nitric oxide  (EXP,ISO)
nitrites  (ISO)
nitrofen  (ISO)
nitrofurantoin  (ISO)
nitroprusside  (ISO)
NS-398  (ISO)
O-methyleugenol  (EXP)
ochratoxin A  (ISO)
okadaic acid  (ISO)
olmesartan  (EXP,ISO)
oltipraz  (ISO)
omeprazole  (ISO)
ouabain  (ISO)
ozone  (ISO)
Pachymic acid  (EXP,ISO)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
parathion  (ISO)
PD 168393  (ISO)
PD123319  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perindopril  (EXP,ISO)
peroxynitrous acid  (ISO)
phenylarsine oxide  (ISO)
phenylephrine  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidic acid  (ISO)
phosphoramidon  (ISO)
pifithrin-?  (ISO)
pindolol  (EXP)
pioglitazone  (ISO)
pirfenidone  (EXP,ISO)
pirinixic acid  (ISO)
potassium atom  (EXP)
potassium dichromate  (ISO)
pravastatin  (ISO)
pregabalin  (ISO)
probenecid  (ISO)
progesterone  (EXP,ISO)
propanal  (EXP)
propranolol  (EXP,ISO)
prostaglandin E1  (EXP)
prostaglandin E2  (ISO)
prostaglandin I2  (ISO)
prostaglandins E  (ISO)
purine-6-thiol  (ISO)
purines  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP,ISO)
quinacrine  (ISO)
quinapril hydrochloride  (ISO)
raloxifene  (EXP)
reactive oxygen species  (EXP,ISO)
reboxetine  (EXP)
resveratrol  (EXP,ISO)
rotenone  (EXP,ISO)
rottlerin  (ISO)
rutin  (ISO)
salubrinal  (ISO)
saralasin  (ISO)
SB 203580  (ISO)
scopolamine  (EXP)
sevoflurane  (ISO)
sildenafil citrate  (EXP,ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium atom  (EXP,ISO)
sodium chloride  (EXP,ISO)
sodium fluoride  (ISO)
Soman  (ISO)
spironolactone  (EXP,ISO)
streptozocin  (ISO)
succimer  (EXP)
sucrose  (ISO)
sulfadimethoxine  (ISO)
sulforaphane  (ISO)
sunitinib  (EXP)
superoxide  (EXP,ISO)
tamibarotene  (ISO)
tamoxifen  (EXP)
taurine  (ISO)
taurolithocholic acid sulfate  (ISO)
tauroursodeoxycholic acid  (ISO)
telmisartan  (ISO)
temozolomide  (EXP)
testosterone  (ISO)
Testosterone propionate  (ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
Theaflavin 3,3'-digallate  (ISO)
thiabendazole  (ISO)
thioacetamide  (ISO)
thiopental  (EXP)
Thiorphan  (EXP,ISO)
Tiron  (EXP,ISO)
titanium dioxide  (EXP,ISO)
torasemide  (ISO)
trandolapril  (ISO)
trans-piceid  (ISO)
tributylstannane  (ISO)
trichloroethene  (ISO)
triclosan  (EXP)
triticonazole  (ISO)
troglitazone  (EXP)
tyrphostin AG 1478  (ISO)
U-73122  (ISO)
valproic acid  (EXP,ISO)
valsartan  (EXP,ISO)
Vinpocetine  (ISO)
vismodegib  (EXP)
wortmannin  (ISO)
xanthone  (ISO)
xestospongin C  (ISO)
zaragozic acid A  (ISO)
zearalenone  (EXP)
zinc atom  (EXP,ISO)
zinc protoporphyrin  (EXP)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aldosterone secretion  (ISO)
angiotensin-activated signaling pathway  (IDA)
angiotensin-mediated drinking behavior  (ISO)
angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure  (ISO)
artery smooth muscle contraction  (ISO)
associative learning  (ISO)
astrocyte activation  (ISO)
blood vessel development  (ISO)
blood vessel remodeling  (TAS)
brain renin-angiotensin system  (ISO)
branching involved in ureteric bud morphogenesis  (ISO)
cell growth involved in cardiac muscle cell development  (ISO)
cell population proliferation  (ISO)
cell surface receptor signaling pathway  (ISO)
cell-cell signaling  (TAS)
cell-matrix adhesion  (ISO)
cellular response to angiotensin  (ISO)
cellular response to mechanical stimulus  (ISO)
cytokine production  (ISO)
drinking behavior  (ISO)
ERK1 and ERK2 cascade  (ISO)
establishment of blood-nerve barrier  (ISO)
extracellular matrix organization  (ISO)
female pregnancy  (ISO)
fibroblast proliferation  (ISO)
G protein-coupled receptor signaling pathway  (IDA,ISO)
G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger  (TAS)
hormone metabolic process  (ISO)
intracellular sodium ion homeostasis  (ISO)
kidney development  (IMP,ISO)
low-density lipoprotein particle remodeling  (NAS)
maintenance of blood vessel diameter homeostasis by renin-angiotensin  (IDA,TAS)
MAPK cascade  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of gene expression  (IDA)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of neurotrophin TRK receptor signaling pathway  (IDA)
negative regulation of smooth muscle cell proliferation  (ISO)
negative regulation of tissue remodeling  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
neuron apoptotic process  (ISO)
nitric oxide-cGMP-mediated signaling  (TAS)
operant conditioning  (ISO)
organ growth  (ISO)
ovarian follicle rupture  (ISO)
peristalsis  (ISO)
phospholipase C-activating G protein-coupled receptor signaling pathway  (NAS)
positive regulation of blood pressure  (ISO)
positive regulation of branching involved in ureteric bud morphogenesis  (IDA)
positive regulation of canonical NF-kappaB signal transduction  (ISO)
positive regulation of cardiac muscle cell apoptotic process  (ISO)
positive regulation of cardiac muscle hypertrophy  (ISS)
positive regulation of cell population proliferation  (ISO)
positive regulation of cytokine production  (TAS)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of DNA-templated transcription  (IDA)
positive regulation of endothelial cell migration  (IDA)
positive regulation of epidermal growth factor receptor signaling pathway  (IDA)
positive regulation of epithelial to mesenchymal transition  (ISS)
positive regulation of extracellular matrix assembly  (IDA)
positive regulation of extracellular matrix constituent secretion  (ISO)
positive regulation of extrinsic apoptotic signaling pathway  (IDA)
positive regulation of fatty acid biosynthetic process  (ISO)
positive regulation of fibroblast proliferation  (ISS)
positive regulation of gap junction assembly  (IGI)
positive regulation of gene expression  (ISO)
positive regulation of inflammatory response  (TAS)
positive regulation of insulin receptor signaling pathway  (ISO)
positive regulation of L-arginine import across plasma membrane  (ISO)
positive regulation of L-lysine import across plasma membrane  (ISO)
positive regulation of macrophage derived foam cell differentiation  (IDA)
positive regulation of MAPK cascade  (ISO)
positive regulation of membrane hyperpolarization  (IMP)
positive regulation of miRNA transcription  (IMP)
positive regulation of multicellular organism growth  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of norepinephrine secretion  (ISO)
positive regulation of organ growth  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IDA)
positive regulation of protein metabolic process  (IDA)
positive regulation of reactive oxygen species metabolic process  (TAS)
positive regulation of superoxide anion generation  (ISO)
positive regulation of vascular associated smooth muscle cell migration  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
protein import into nucleus  (ISO)
regulation of apoptotic process  (IBA,IEA,ISO)
regulation of blood pressure  (IGI,ISO)
regulation of blood volume by renin-angiotensin  (NAS)
regulation of calcium ion transport  (ISO)
regulation of cardiac conduction  (IGI)
regulation of cell growth  (NAS)
regulation of cell population proliferation  (NAS)
regulation of extracellular matrix assembly  (IGI)
regulation of gene expression  (ISO)
regulation of heart rate  (ISO)
regulation of inflammatory response  (ISO)
regulation of long-term neuronal synaptic plasticity  (ISO)
regulation of renal output by angiotensin  (ISO,NAS)
regulation of renal sodium excretion  (NAS)
regulation of systemic arterial blood pressure by circulatory renin-angiotensin  (ISO)
regulation of systemic arterial blood pressure by renin-angiotensin  (IEA)
regulation of transmission of nerve impulse  (ISO)
regulation of vasoconstriction  (NAS)
renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure  (ISO)
renal system process  (IDA)
renin-angiotensin regulation of aldosterone production  (ISO,NAS)
response to angiotensin  (IDA)
response to cold  (ISO)
response to estradiol  (ISO)
response to mechanical stimulus  (ISO)
response to muscle activity involved in regulation of muscle adaptation  (ISS)
response to salt stress  (ISO)
smooth muscle cell differentiation  (ISO)
smooth muscle cell proliferation  (ISO)
stress-activated MAPK cascade  (ISO)
uterine smooth muscle contraction  (ISO)
vascular associated smooth muscle cell proliferation  (ISO)
vasoconstriction  (IEA,ISO)
vasodilation  (ISO)
vasopressin secretion  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Attenuation of angiotensin II-induced hypertension and cardiac hypertrophy in transgenic mice overexpressing a type 1 receptor mutant. Ahmad S, etal., Am J Hypertens. 2009 Dec;22(12):1320-5. doi: 10.1038/ajh.2009.181. Epub 2009 Sep 24.
2. Metabolic syndrome biomarkers and early breast cancer in Saudi women: evidence for the presence of a systemic stress response and/or a pre-existing metabolic syndrome-related neoplasia risk? Alokail MS, etal., BMC Cancer. 2013 Feb 4;13:54. doi: 10.1186/1471-2407-13-54.
3. Angiotensinogen promoter and angiotensinogen II receptor type 1 gene polymorphisms and incidence of ischemic stroke and neurologic phenotype in Fabry disease. Altarescu G, etal., Biomarkers. 2013 Nov;18(7):595-600. doi: 10.3109/1354750X.2013.836244. Epub 2013 Sep 10.
4. Candesartan cilexetil protects from cardiac myosin induced cardiotoxicity via reduction of endoplasmic reticulum stress and apoptosis in rats: involvement of ACE2-Ang (1-7)-mas axis. Arumugam S, etal., Toxicology. 2012 Jan 27;291(1-3):139-45. doi: 10.1016/j.tox.2011.11.008. Epub 2011 Nov 23.
5. Lack of association between angiotensinogen polymorphism (M235T) and cerebrovascular disease and carotid atheroma. Barley J, etal., J Hum Hypertens. 1995 Aug;9(8):681-3.
6. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
7. Telmisartan Prevents Alveolar Bone Loss by Decreasing the Expression of Osteoclasts Markers in Hypertensive Rats With Periodontal Disease. Brito VGB, etal., Front Pharmacol. 2020 Nov 11;11:579926. doi: 10.3389/fphar.2020.579926. eCollection 2020.
8. The renin-angiotensin and the kallikrein-kinin systems. Campbell DJ Int J Biochem Cell Biol. 2003 Jun;35(6):784-91.
9. Genetic predisposition to thrombophilia in inflammatory bowel disease. Cappello M, etal., J Clin Gastroenterol. 2011 Mar;45(3):e25-9. doi: 10.1097/MCG.0b013e3181eb6132.
10. Promoter polymorphism G-6A, which modulates angiotensinogen gene expression, is associated with non-familial sick sinus syndrome. Chen JY, etal., PLoS One. 2012;7(1):e29951. doi: 10.1371/journal.pone.0029951. Epub 2012 Jan 5.
11. Ang-(1-7) might prevent the development of monocrotaline induced pulmonary arterial hypertension in rats. Chen L, etal., Eur Rev Med Pharmacol Sci. 2011 Jan;15(1):1-7.
12. Hepatic expression of candidate genes in patients with alcoholic hepatitis: correlation with disease severity. Colmenero J, etal., Gastroenterology. 2007 Feb;132(2):687-97. Epub 2006 Dec 20.
13. Angiotensin-(1-7) reduces fibrosis in orthotopic breast tumors. Cook KL, etal., Cancer Res. 2010 Nov 1;70(21):8319-28. Epub 2010 Sep 13.
14. The angiotensin II type 2 receptor causes constitutive growth of cardiomyocytes and does not antagonize angiotensin II type 1 receptor-mediated hypertrophy. D'Amore A, etal., Hypertension. 2005 Dec;46(6):1347-54. Epub 2005 Nov 14.
15. Evidence that the vasodilator angiotensin-(1-7)-Mas axis plays an important role in erectile function. da Costa Goncalves AC, etal., Am J Physiol Heart Circ Physiol. 2007 Oct;293(4):H2588-96. Epub 2007 Jul 6.
16. Renin-angiotensin system gene polymorphisms in children with Henoch-Schonlein purpura in West China. Desong Liu, etal., J Renin Angiotensin Aldosterone Syst. 2010 Dec;11(4):248-55. doi: 10.1177/1470320310374214. Epub 2010 Aug 11.
17. Aberrant activation of the intrarenal renin-angiotensin system in the developing kidneys of type 2 diabetic rats. Fan YY, etal., Horm Metab Res. 2013 May;45(5):338-43. doi: 10.1055/s-0032-1331256. Epub 2013 Jan 15.
18. AGT and ACE genes influence classic mitral valve prolapse predisposition in Marfan patients. Fatini C, etal., Int J Cardiol. 2008 Jan 24;123(3):293-7. Epub 2007 Mar 26.
19. Thalidomide-induced angiopoietin 2, Notch1 and Dll4 downregulation under hypoxic condition in tissues with gastrointestinal vascular malformation and human umbilical vein endothelial cells. Feng Q, etal., J Dig Dis. 2014 Feb;15(2):85-95. doi: 10.1111/1751-2980.12114.
20. Genetic polymorphisms of the renin-angiotensin system in breast cancer patients. Fishchuk LE and Gorovenko NG, Exp Oncol. 2013 Jun;35(2):101-4.
21. A molecular variant of angiotensinogen is associated with diabetic nephropathy in IDDM. Fogarty DG, etal., Diabetes. 1996 Sep;45(9):1204-8.
22. Relationship between polymorphisms in the renin-angiotensin system and nephropathy in type 2 diabetic patients. Fradin S, etal., Diabetes Metab. 2002 Feb;28(1):27-32.
23. Analysis of renin-angiotensin-aldosterone system gene polymorphisms in resistant hypertension. Freitas SR, etal., Braz J Med Biol Res. 2007 Mar;40(3):309-16.
24. Therapeutic effects of postischemic treatment with hypotensive doses of an angiotensin II receptor blocker on transient focal cerebral ischemia. Fu H, etal., J Hypertens. 2011 Nov;29(11):2210-9. doi: 10.1097/HJH.0b013e32834bbb30.
25. Polymorphisms in thrombophilia and renin-angiotensin system pathways, preterm delivery, and evidence of placental hemorrhage. Gargano JW, etal., Am J Obstet Gynecol. 2009 Sep;201(3):317.e1-9. doi: 10.1016/j.ajog.2009.05.060.
26. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
27. Differential roles of Angiotensinogen and Angiotensin Receptor type 1 polymorphisms in breast cancer risk. Gonzalez-Zuloeta Ladd AM, etal., Breast Cancer Res Treat. 2007 Mar;101(3):299-304. Epub 2006 Jul 6.
28. Association Between the M268T Polymorphism in the Angiotensinogen Gene and Essential Hypertension in a South Indian Population. Gopi Chand M, etal., Biochem Genet. 2011 Feb 11.
29. The renin-angiotensin system and hypertension in autosomal recessive polycystic kidney disease. Goto M, etal., Pediatr Nephrol. 2010 Dec;25(12):2449-57. doi: 10.1007/s00467-010-1621-z. Epub 2010 Aug 27.
30. The levels of renin-angiotensin related components are modified in the hippocampus of rats submitted to pilocarpine model of epilepsy. Gouveia TL, etal., Neurochem Int. 2012 Jul;61(1):54-62. doi: 10.1016/j.neuint.2012.04.012. Epub 2012 Apr 20.
31. Serum proteomic profile of cutaneous malignant melanoma and relation to cancer progression: association to tumor derived alpha-N-acetylgalactosaminidase activity. Greco M, etal., Cancer Lett. 2009 Oct 8;283(2):222-9. doi: 10.1016/j.canlet.2009.04.001. Epub 2009 Apr 25.
32. Angiotensin I-converting enzyme and angiotensinogen gene polymorphisms in non-insulin-dependent diabetes mellitus. Lack of relationship with diabetic nephropathy and retinopathy in a Caucasian Mediterranean population. Gutierrez C, etal., Metabolism. 1997 Aug;46(8):976-80.
33. Exercise capacity after coarctation repair relates to the c.46A > G genomic polymorphism of the ss2-adrenoreceptor and the c.704T > C angiotensinogen polymorphism. Hager A, etal., Eur J Prev Cardiol. 2012 Apr;19(2):199-204. doi: 10.1177/1741826711399991. Epub 2011 Feb 25.
34. Lipoprotein-genotype associations in Trinidadian neonates. Hegele RA, etal., Clin Biochem. 1999 Aug;32(6):429-37.
35. Upregulation of hepatic angiotensin-converting enzyme 2 (ACE2) and angiotensin-(1-7) levels in experimental biliary fibrosis. Herath CB, etal., J Hepatol. 2007 Sep;47(3):387-95. Epub 2007 Apr 2.
36. Effects of circulating and local uteroplacental angiotensin II in rat pregnancy. Hering L, etal., Hypertension. 2010 Aug;56(2):311-8. doi: 10.1161/HYPERTENSIONAHA.110.150961. Epub 2010 Jun 7.
37. Urinary excretion of angiotensin I, II, arginine vasopressin and oxytocin in patients with anaphylactoid reactions. Hermann K, etal., Clin Exp Allergy. 1992 Sep;22(9):845-53.
38. Increased insulin-stimulated expression of arterial angiotensinogen and angiotensin type 1 receptor in patients with type 2 diabetes mellitus and atheroma. Hodroj W, etal., Arterioscler Thromb Vasc Biol. 2007 Mar;27(3):525-31. Epub 2006 Dec 14.
39. Association of 3 gene polymorphisms with atopic diseases. Holla L, etal., J Allergy Clin Immunol. 1999 Apr;103(4):702-8.
40. A vaccine for hypertension based on peptide AngI-R: a pilot study. Hong F, etal., Int J Cardiol. 2011 Apr 1;148(1):76-84. doi: 10.1016/j.ijcard.2009.10.027. Epub 2009 Nov 24.
41. Maternal Tryptophan Supplementation Protects Adult Rat Offspring against Hypertension Programmed by Maternal Chronic Kidney Disease: Implication of Tryptophan-Metabolizing Microbiome and Aryl Hydrocarbon Receptor. Hsu CN, etal., Int J Mol Sci. 2020 Jun 26;21(12):4552. doi: 10.3390/ijms21124552.
42. Pleiotropic AT1 receptor signaling pathways mediating physiological and pathogenic actions of angiotensin II. Hunyady L and Catt KJ, Mol Endocrinol. 2006 May;20(5):953-70. Epub 2005 Sep 1.
43. Attenuation of hypertension-mediated glomerulosclerosis in conjunction with increased angiotensin (1-7). Igase M, etal., Ther Adv Cardiovasc Dis. 2011 Dec;5(6):297-304. doi: 10.1177/1753944711429343. Epub 2011 Nov 16.
44. Relation between renin-angiotensin-aldosterone system and otosclerosis: a genetic association and in vitro study. Imauchi Y, etal., Otol Neurotol. 2008 Apr;29(3):295-301.
45. Angiotensinogen gene polymorphism in Japanese patients with hypertrophic cardiomyopathy. Ishanov A, etal., Am Heart J. 1997 Feb;133(2):184-9.
46. Molecular basis of human hypertension: role of angiotensinogen. Jeunemaitre X, etal., Cell 1992 Oct 2;71(1):169-80.
47. Chronic infusion of enalaprilat into hypothalamic paraventricular nucleus attenuates angiotensin II-induced hypertension and cardiac hypertrophy by restoring neurotransmitters and cytokines. Kang YM, etal., Toxicol Appl Pharmacol. 2014 Feb 1;274(3):436-44. doi: 10.1016/j.taap.2013.12.001. Epub 2013 Dec 14.
48. Application of angiotensin II to healthy rat sciatic nerve can produce neuropathy without associated vasculopathy. Kasselman LJ and Rutkove SB, Muscle Nerve. 2010 Dec;42(6):959-65. doi: 10.1002/mus.21767. Epub 2010 Sep 30.
49. Angiotensin II in the lesional skin of systemic sclerosis patients contributes to tissue fibrosis via angiotensin II type 1 receptors. Kawaguchi Y, etal., Arthritis Rheum. 2004 Jan;50(1):216-26.
50. Role of intra-renal angiotensin system activation, oxidative stress, inflammation and impaired Nrf2 activity in the progression of focal glomerulosclerosis. Kim HJ, etal., J Pharmacol Exp Ther. 2011 Feb 25.
51. Enhanced intrarenal angiotensinogen contributes to early renal injury in spontaneously hypertensive rats. Kobori H, etal., J Am Soc Nephrol. 2005 Jul;16(7):2073-80. Epub 2005 May 11.
52. The effects of angiotensin IV analogs on long-term potentiation within the CA1 region of the hippocampus in vitro. Kramar EA, etal., Brain Res. 2001 Apr 6;897(1-2):114-21.
53. Upregulation of a local renin-angiotensin system in the rat carotid body during chronic intermittent hypoxia. Lam SY, etal., Exp Physiol. 2014 Jan;99(1):220-31. doi: 10.1113/expphysiol.2013.074591. Epub 2013 Sep 13.
54. Targeting the renin-angiotensin system: what's new? Leckie BJ Curr Med Chem Cardiovasc Hematol Agents. 2005 Jan;3(1):23-32.
55. Angiotensin II increases periostin expression via Ras/p38 MAPK/CREB and ERK1/2/TGF-{beta}1 pathways in cardiac fibroblasts. Li L, etal., Cardiovasc Res. 2011 Mar 2.
56. Increased renin excretion is associated with augmented urinary angiotensin II levels in chronic angiotensin II-infused hypertensive rats. Liu L, etal., Am J Physiol Renal Physiol. 2011 Dec;301(6):F1195-201. doi: 10.1152/ajprenal.00339.2011. Epub 2011 Aug 24.
57. Brain-specific restoration of angiotensin II corrects renal defects seen in angiotensinogen-deficient mice. Lochard N, etal., J Biol Chem 2003 Jan 24;278(4):2184-9. Epub 2002 Oct 23.
58. The expression of angiotensin-converting enzyme 2-angiotensin-(1-7)-Mas receptor axis are upregulated after acute cerebral ischemic stroke in rats. Lu J, etal., Neuropeptides. 2013 Oct;47(5):289-95. doi: 10.1016/j.npep.2013.09.002. Epub 2013 Sep 18.
59. Effect of GPE-AGT nanoparticle shRNA transfection system mediated RNAi on early atherosclerotic lesion. Lu P, etal., Int J Clin Exp Pathol. 2012;5(7):698-706. Epub 2012 Sep 5.
60. Expression of angiotensinogen during hepatic fibrogenesis and its effect on hepatic stellate cells. Lu P, etal., Med Sci Monit. 2011 Sep;17(9):BR248-56.
61. Angiotensin II receptor blockade inhibits pneumocyte apoptosis in experimental meconium aspiration. Lukkarinen H, etal., Pediatr Res. 2004 Feb;55(2):326-33. Epub 2003 Nov 6.
62. [Renin-angiotensin system in mesenteric adipose tissues in rats with metabolic syndrome] Ma LQ, etal., Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2006 Dec;28(6):770-5.
63. [Angiotensinogen gene T174M polymorphism: opposite relationships with essential hypertension and obesity in a homogeneous population from Majorca (Baleric Islands, Spain)] Marco J, etal., Nefrologia. 2005;25(6):629-36.
64. Upregulation of Brain Renin Angiotensin System by 27-Hydroxycholesterol in Alzheimer's Disease. Mateos L, etal., J Alzheimers Dis. 2011 Feb 4.
65. Angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas axis protects against lung fibrosis by inhibiting the MAPK/NF-kappaB pathway. Meng Y, etal., Am J Respir Cell Mol Biol. 2014 Apr;50(4):723-36. doi: 10.1165/rcmb.2012-0451OC.
66. Methylglyoxal augments angiotensin II-induced contraction in rat isolated carotid artery. Mukohda M, etal., J Pharmacol Sci. 2010;114(4):390-8. Epub 2010 Nov 9.
67. Evaluation of kidney dysfunction and angiotensinogen as an early novel biomarker of intrauterine growth restricted offspring rats. Murano Y, etal., Pediatr Res. 2015 Dec;78(6):678-82. doi: 10.1038/pr.2015.153. Epub 2015 Aug 13.
68. Activation of cardiac renin-angiotensin system in unstable angina. Neri Serneri GG, etal., J Am Coll Cardiol. 2001 Jul;38(1):49-55.
69. ACE2 and ANG-(1-7) in the rat uterus during early and late gestation. Neves LA, etal., Am J Physiol Regul Integr Comp Physiol. 2008 Jan;294(1):R151-61. Epub 2007 Oct 31.
70. Homozygosity for angiotensinogen 235T variant increases the risk of myocardial infarction in patients with multi-vessel coronary artery disease. Olivieri O, etal., J Hypertens. 2001 May;19(5):879-84.
71. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
72. Renin-angiotensin system gene polymorphisms: association with susceptibility to Henoch-Schonlein purpura and renal involvement. Ozkaya O, etal., Clin Rheumatol. 2006 Nov;25(6):861-5. Epub 2006 Mar 7.
73. AT2 receptors: beneficial counter-regulatory role in cardiovascular and renal function. Padia SH and Carey RM, Pflugers Arch. 2013 Jan;465(1):99-110. doi: 10.1007/s00424-012-1146-3. Epub 2012 Sep 5.
74. Renal angiotensin type 2 receptors mediate natriuresis via angiotensin III in the angiotensin II type 1 receptor-blocked rat. Padia SH, etal., Hypertension. 2006 Mar;47(3):537-44. Epub 2005 Dec 27.
75. Survival in type 2 diabetic patients in dialysis and the number of risk alleles in polymorphisms of the renin-angiotensin system genes. Padro-Miquel A, etal., Clin Biochem. 2009 Jan;42(1-2):5-11. doi: 10.1016/j.clinbiochem.2008.10.011. Epub 2008 Nov 5.
76. The predominant role of brain angiotensinogen and angiotensin in environmentally induced hypertension. Peng J, etal., Regul Pept 2002 Dec 31;110(1):25-32.
77. Reduction of cold-induced hypertension by antisense oligodeoxynucleotides to angiotensinogen mRNA and AT1-receptor mRNA in brain and blood. Peng JF, etal., Hypertension. 1998 Jun;31(6):1317-23.
78. Physical, behavioural and genetic predictors of adult hypertension: the findings of the Kaunas Cardiovascular Risk Cohort study. Petkeviciene J, etal., PLoS One. 2014 Oct 14;9(10):e109974. doi: 10.1371/journal.pone.0109974. eCollection 2014.
79. Reduced circulating levels of angiotensin-(1--7) in systemic sclerosis: a new pathway in the dysregulation of endothelial-dependent vascular tone control. Pignone A, etal., Ann Rheum Dis. 2007 Oct;66(10):1305-10. Epub 2007 Mar 14.
80. Angiotensinogen M235T and T174M gene polymorphisms in combination doubles the risk of mortality in heart failure. Pilbrow AP, etal., Hypertension. 2007 Feb;49(2):322-7. Epub 2006 Dec 4.
81. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
82. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
83. Genetic analysis of angiotensinogen gene polymorphisms (M235T and T174M) in Romanian patients with essential arterial hypertension. Procopciuc LM, etal., Rom J Intern Med. 2005;43(1-2):61-71.
84. Angiotensin III: a central regulator of vasopressin release and blood pressure. Reaux A, etal., Trends Endocrinol Metab. 2001 May-Jun;12(4):157-62.
85. The continuing saga of the AT2 receptor: a case of the good, the bad, and the innocuous. Reudelhuber TL Hypertension. 2005 Dec;46(6):1261-2. Epub 2005 Nov 14.
86. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
87. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
88. RGD HPO Phenotype Annotation Pipeline RGD automated import pipeline for human HPO-to-gene-to-disease annotations
89. Role of angiotensin II in ischemia/reperfusion-induced leukocyte-endothelium interactions in the colon. Riaz AA, etal., FASEB J. 2004 May;18(7):881-3. doi: 10.1096/fj.03-0502fje. Epub 2004 Mar 4.
90. Polymorphisms of the renin-angiotensin system are associated with blood pressure, atherosclerosis and cerebral white matter pathology. Rijn MJ, etal., J Neurol Neurosurg Psychiatry. 2007 Jan 12;.
91. AT-1 receptor and phospholipase C are involved in angiotensin III modulation of hypothalamic noradrenergic transmission. Rodriguez-Campos M, etal., Cell Mol Neurobiol. 2000 Dec;20(6):747-62.
92. Role of IL-6 in angiotensin II-induced retinal vascular inflammation. Rojas M, etal., Invest Ophthalmol Vis Sci. 2010 Mar;51(3):1709-18. doi: 10.1167/iovs.09-3375. Epub 2009 Oct 15.
93. Effects of imatinib mesylate on renin-angiotensin system (RAS) activity during the clinical course of chronic myeloid leukaemia. Sayitoglu M, etal., J Int Med Res. 2009 Jul-Aug;37(4):1018-28.
94. Angiotensinogen M235T polymorphism and the risk of myocardial infarction and stroke among hypertensive patients on ACE-inhibitors or beta-blockers. Schelleman H, etal., Eur J Hum Genet. 2007 Apr;15(4):478-84. Epub 2007 Feb 14.
95. No evidence for association between the renin-angiotensin-aldosterone system and otosclerosis in a large Belgian-Dutch population. Schrauwen I, etal., Otol Neurotol. 2009 Dec;30(8):1079-83. doi: 10.1097/MAO.0b013e3181ab3058.
96. Polymorphisms of renin-angiotensin system genes as a risk factor for high-altitude pulmonary oedema. Stobdan T, etal., J Renin Angiotensin Aldosterone Syst. 2011 Mar 10.
97. Angiotensin-(1-7) inhibits vascular calcification in rats. Sui YB, etal., Peptides. 2013 Apr;42:25-34. doi: 10.1016/j.peptides.2012.12.023. Epub 2013 Jan 3.
98. Salt-induced renal injury in SHRs is mediated by AT1 receptor activation. Susic D, etal., J Hypertens. 2011 Apr;29(4):716-23.
99. Angiotensinogen gene polymorphism (Met235Thr) influences visceral obesity and insulin resistance in obese Japanese women. Takakura Y, etal., Metabolism. 2006 Jun;55(6):819-24.
100. Angiotensin-(1-7) inhibits growth of cardiac myocytes through activation of the mas receptor. Tallant EA, etal., Am J Physiol Heart Circ Physiol. 2005 Oct;289(4):H1560-6. Epub 2005 Jun 10.
101. The role of HIF-1, angiopoietin-2, Dll4 and Notch1 in bleeding gastrointestinal vascular malformations and thalidomide-associated actions: a pilot in vivo study. Tan HH, etal., J Dig Dis. 2011 Oct;12(5):349-56. doi: 10.1111/j.1751-2980.2011.00506.x.
102. Polymorphisms within the angiotensinogen gene (GT-repeat) and the risk of stroke in pediatric patients with sickle cell disease: a case-control study. Tang DC, etal., Am J Hematol. 2001 Nov;68(3):164-9.
103. Renin-angiotensin system gene polymorphisms and atrial fibrillation: a regression approach for the detection of gene-gene interactions in a large hospitalized population. Tsai CT, etal., Cardiology. 2008;111(1):1-7. doi: 10.1159/000113419. Epub 2008 Feb 1.
104. Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes. Tsuchida S, etal., J Clin Invest 1998 Feb 15;101(4):755-60.
105. Addition of angiotensin II type 1 receptor blocker to CCR2 antagonist markedly attenuates crescentic glomerulonephritis. Urushihara M, etal., Hypertension. 2011 Mar;57(3):586-93. Epub 2011 Jan 31.
106. Inhibition of corneal neovascularization by blocking the angiotensin II type 1 receptor. Usui T, etal., Invest Ophthalmol Vis Sci. 2008 Oct;49(10):4370-6. doi: 10.1167/iovs.07-0964.
107. Genetic polymorphisms of the renin-angiotensin system and complications of insulin-dependent diabetes mellitus. van Ittersum FJ, etal., Nephrol Dial Transplant. 2000 Jul;15(7):1000-7.
108. Angiotensinogen promoter sequence variants in essential hypertension. Velez DR, etal., Am J Hypertens. 2006 Dec;19(12):1278-85.
109. ACE2 and Ang-(1-7) confer protection against development of diabetic retinopathy. Verma A, etal., Mol Ther. 2012 Jan;20(1):28-36. doi: 10.1038/mt.2011.155. Epub 2011 Jul 26.
110. A molecular variant of angiotensinogen associated with preeclampsia. Ward K, etal., Nat Genet 1993 May;4(1):59-61.
111. Angiotensin II controls occludin function and is required for blood brain barrier maintenance: relevance to multiple sclerosis. Wosik K, etal., J Neurosci. 2007 Aug 22;27(34):9032-42.
112. Lack of association of polymorphisms of the angiotensin converting enzyme and angiotensinogen genes with nonfamilial hypertrophic or dilated cardiomyopathy. Yamada Y, etal., Am J Hypertens. 1997 Aug;10(8):921-8.
113. Mechanisms of Ghrelin anti-heart failure: inhibition of Ang II-induced cardiomyocyte apoptosis by down-regulating AT1R expression. Yang C, etal., PLoS One. 2014 Jan 21;9(1):e85785. doi: 10.1371/journal.pone.0085785. eCollection 2014.
114. Activation of the renin-angiotensin system in anti-glomerular basement membrane antibody-induced glomerulonephritis. Yayama K, etal., Biol Pharm Bull. 1995 Mar;18(3):411-5.
115. Elevation of plasma angiotensinogen in rats with experimentally induced nephrosis. Yayama K, etal., Nephron. 1993;63(1):89-93.
116. Olmesartan attenuates cardiac remodeling through DLL4/Notch1 pathway activation in pressure overload mice. You J, etal., J Cardiovasc Pharmacol. 2013 Feb;61(2):142-51. doi: 10.1097/FJC.0b013e31827a0278.
117. Impairment of Cardiac Function and Remodeling Induced by Myocardial Infarction in Rats are Attenuated by the Nonpeptide Angiotensin-(1-7) Analog AVE 0991. Zeng WT, etal., Cardiovasc Ther. 2010 Dec 19. doi: 10.1111/j.1755-5922.2010.00255.x.
118. Angiotensin (1-7) protects against stress-induced gastric lesions in rats. Zhu D, etal., Biochem Pharmacol. 2014 Feb 1;87(3):467-76. doi: 10.1016/j.bcp.2013.10.026. Epub 2013 Nov 11.
119. Regulation of angiotensin-(1-7) and angiotensin II type 1 receptor by telmisartan and losartan in adriamycin-induced rat heart failure. Zong WN, etal., Acta Pharmacol Sin. 2011 Nov;32(11):1345-50. doi: 10.1038/aps.2011.96. Epub 2011 Oct 3.
Additional References at PubMed
PMID:12173   PMID:28321   PMID:1132082   PMID:1378723   PMID:1567413   PMID:1692023   PMID:1756856   PMID:2286380   PMID:2834384   PMID:2885106   PMID:2924688   PMID:3034901  
PMID:3397061   PMID:3579322   PMID:3934016   PMID:4300938   PMID:6089875   PMID:7259779   PMID:7539791   PMID:7607642   PMID:7744780   PMID:7888785   PMID:7961807   PMID:8125298  
PMID:8185599   PMID:8230088   PMID:8477848   PMID:8548433   PMID:8621667   PMID:8959747   PMID:9120024   PMID:9492317   PMID:9694881   PMID:9757569   PMID:9814470   PMID:10406457  
PMID:10419812   PMID:10619573   PMID:10899625   PMID:10969042   PMID:11024214   PMID:11027844   PMID:11053482   PMID:11082147   PMID:11095476   PMID:11096141   PMID:11106322   PMID:11114694  
PMID:11136175   PMID:11142763   PMID:11157174   PMID:11181802   PMID:11191642   PMID:11200871   PMID:11208365   PMID:11213892   PMID:11230286   PMID:11234373   PMID:11244011   PMID:11278902  
PMID:11288810   PMID:11300226   PMID:11317203   PMID:11325075   PMID:11330506   PMID:11330874   PMID:11341749   PMID:11345362   PMID:11354780   PMID:11355019   PMID:11359462   PMID:11372768  
PMID:11422735   PMID:11422818   PMID:11431175   PMID:11447495   PMID:11463770   PMID:11484170   PMID:11507973   PMID:11531970   PMID:11544438   PMID:11575217   PMID:11577832   PMID:11593098  
PMID:11668351   PMID:11675943   PMID:11677359   PMID:11677365   PMID:11688760   PMID:11689223   PMID:11707217   PMID:11707427   PMID:11707686   PMID:11709400   PMID:11711524   PMID:11714857  
PMID:11720807   PMID:11725160   PMID:11731937   PMID:11737220   PMID:11747312   PMID:11751698   PMID:11756575   PMID:11776100   PMID:11803527   PMID:11815627   PMID:11849656   PMID:11860821  
PMID:11862023   PMID:11865575   PMID:11882570   PMID:11910300   PMID:11910301   PMID:11918988   PMID:11923478   PMID:11923700   PMID:11924723   PMID:11926202   PMID:11963567   PMID:11997278  
PMID:12006677   PMID:12015946   PMID:12031704   PMID:12037699   PMID:12040348   PMID:12045255   PMID:12051013   PMID:12081721   PMID:12082592   PMID:12095411   PMID:12118911   PMID:12130713  
PMID:12145290   PMID:12164881   PMID:12169209   PMID:12173461   PMID:12181363   PMID:12181364   PMID:12187393   PMID:12194787   PMID:12205735   PMID:12234952   PMID:12270765   PMID:12352892  
PMID:12394950   PMID:12417054   PMID:12425365   PMID:12426159   PMID:12431442   PMID:12446192   PMID:12446468   PMID:12449516   PMID:12450315   PMID:12454231   PMID:12469628   PMID:12476421  
PMID:12476891   PMID:12477932   PMID:12479284   PMID:12482638   PMID:12511523   PMID:12511525   PMID:12513040   PMID:12536339   PMID:12544508   PMID:12548125   PMID:12556231   PMID:12559679  
PMID:12569265   PMID:12575194   PMID:12576245   PMID:12579398   PMID:12579405   PMID:12597535   PMID:12611423   PMID:12624946   PMID:12627873   PMID:12661912   PMID:12663441   PMID:12663475  
PMID:12669427   PMID:12670743   PMID:12675870   PMID:12695419   PMID:12716844   PMID:12728975   PMID:12743009   PMID:12767551   PMID:12805070   PMID:12811821   PMID:12819040   PMID:12829792  
PMID:12830507   PMID:12832734   PMID:12854169   PMID:12865608   PMID:12874613   PMID:12888892   PMID:12895663   PMID:12898858   PMID:12911327   PMID:12911556   PMID:12932862   PMID:12938141  
PMID:12939534   PMID:12950120   PMID:12964504   PMID:14500990   PMID:14502296   PMID:14508190   PMID:14508191   PMID:14519430   PMID:14521795   PMID:14523024   PMID:14530292   PMID:14565954  
PMID:14569094   PMID:14597849   PMID:14610337   PMID:14625185   PMID:14638622   PMID:14642613   PMID:14643573   PMID:14643574   PMID:14644777   PMID:14648325   PMID:14660489   PMID:14669517  
PMID:14672953   PMID:14688807   PMID:14700505   PMID:14718574   PMID:14749533   PMID:14765837   PMID:14767013   PMID:14767903   PMID:14961043   PMID:14970360   PMID:14973087   PMID:14997233  
PMID:15013293   PMID:15013322   PMID:15013333   PMID:15017542   PMID:15023884   PMID:15031629   PMID:15042429   PMID:15044674   PMID:15045574   PMID:15055256   PMID:15062885   PMID:15067378  
PMID:15067738   PMID:15075192   PMID:15076187   PMID:15077204   PMID:15079791   PMID:15082899   PMID:15097234   PMID:15108186   PMID:15112434   PMID:15112973   PMID:15120696   PMID:15123355  
PMID:15130920   PMID:15131005   PMID:15149328   PMID:15153556   PMID:15153745   PMID:15192838   PMID:15201544   PMID:15201545   PMID:15278435   PMID:15283675   PMID:15294367   PMID:15317677  
PMID:15326089   PMID:15343353   PMID:15353577   PMID:15364762   PMID:15385810   PMID:15386947   PMID:15387996   PMID:15388495   PMID:15448113   PMID:15489334   PMID:15498133   PMID:15504143  
PMID:15505642   PMID:15563875   PMID:15575510   PMID:15599691   PMID:15614026   PMID:15621215   PMID:15624175   PMID:15628301   PMID:15642127   PMID:15649942   PMID:15652490   PMID:15659127  
PMID:15662219   PMID:15668245   PMID:15673342   PMID:15676177   PMID:15718424   PMID:15718497   PMID:15743363   PMID:15754274   PMID:15789057   PMID:15798183   PMID:15803439   PMID:15811183  
PMID:15824464   PMID:15860756   PMID:15869758   PMID:15879922   PMID:15905345   PMID:15914614   PMID:15914769   PMID:15915003   PMID:15922319   PMID:15930094   PMID:15934435   PMID:15941661  
PMID:16006956   PMID:16007303   PMID:16019571   PMID:16045904   PMID:16047641   PMID:16059745   PMID:16061119   PMID:16087781   PMID:16088850   PMID:16105049   PMID:16108768   PMID:16109907  
PMID:16115039   PMID:16116425   PMID:16133060   PMID:16189514   PMID:16199891   PMID:16210856   PMID:16228848   PMID:16231503   PMID:16237761   PMID:16256216   PMID:16266458   PMID:16274774  
PMID:16275260   PMID:16276364   PMID:16280278   PMID:16286570   PMID:16314886   PMID:16335952   PMID:16338465   PMID:16344560   PMID:16352906   PMID:16369102   PMID:16384824   PMID:16386515  
PMID:16387306   PMID:16392768   PMID:16396964   PMID:16487207   PMID:16492203   PMID:16502470   PMID:16520412   PMID:16525944   PMID:16544732   PMID:16565729   PMID:16572049   PMID:16597412  
PMID:16603315   PMID:16609364   PMID:16611471   PMID:16618834   PMID:16635753   PMID:16636191   PMID:16671337   PMID:16672053   PMID:16681991   PMID:16685205   PMID:16685579   PMID:16724011  
PMID:16736244   PMID:16741369   PMID:16754659   PMID:16755155   PMID:16790149   PMID:16844946   PMID:16876684   PMID:16893516   PMID:16911698   PMID:16915040   PMID:16937603   PMID:16938176  
PMID:16940224   PMID:16949687   PMID:16954165   PMID:16963053   PMID:16971959   PMID:16981142   PMID:17003099   PMID:17024648   PMID:17069434   PMID:17069818   PMID:17083063   PMID:17083073  
PMID:17107992   PMID:17112651   PMID:17116328   PMID:17118372   PMID:17124396   PMID:17138938   PMID:17143591   PMID:17159080   PMID:17159089   PMID:17190732   PMID:17196163   PMID:17202846  
PMID:17215849   PMID:17223428   PMID:17257983   PMID:17261659   PMID:17289052   PMID:17291601   PMID:17298481   PMID:17327458   PMID:17342175   PMID:17378368   PMID:17383306   PMID:17389608  
PMID:17404186   PMID:17416596   PMID:17429448   PMID:17448297   PMID:17475670   PMID:17492314   PMID:17499413   PMID:17520398   PMID:17522061   PMID:17524880   PMID:17541127   PMID:17546276  
PMID:17563539   PMID:17569300   PMID:17569879   PMID:17579251   PMID:17586619   PMID:17595324   PMID:17608790   PMID:17624368   PMID:17653210   PMID:17666408   PMID:17689084   PMID:17702963  
PMID:17703433   PMID:17765139   PMID:17785212   PMID:17823594   PMID:17846284   PMID:17851694   PMID:17851801   PMID:17903690   PMID:17903694   PMID:17906677   PMID:17914507   PMID:17921431  
PMID:17921816   PMID:17952138   PMID:17964282   PMID:17975262   PMID:17977523   PMID:17984617   PMID:17988266   PMID:17991883   PMID:17998241   PMID:18029348   PMID:18039931   PMID:18052686  
PMID:18060435   PMID:18069999   PMID:18164957   PMID:18172037   PMID:18175066   PMID:18202720   PMID:18205097   PMID:18212269   PMID:18227406   PMID:18239157   PMID:18240029   PMID:18243211  
PMID:18248681   PMID:18250562   PMID:18260994   PMID:18277167   PMID:18279468   PMID:18292388   PMID:18300856   PMID:18325076   PMID:18328310   PMID:18364271   PMID:18364383   PMID:18404605  
PMID:18409009   PMID:18413162   PMID:18413222   PMID:18413308   PMID:18421480   PMID:18441099   PMID:18446309   PMID:18446580   PMID:18454324   PMID:18475146   PMID:18496132   PMID:18508830  
PMID:18513389   PMID:18543221   PMID:18551010   PMID:18562510   PMID:18562701   PMID:18563171   PMID:18573259   PMID:18575631   PMID:18580852   PMID:18600213   PMID:18607644   PMID:18619701  
PMID:18624398   PMID:18628677   PMID:18630525   PMID:18636314   PMID:18637188   PMID:18645251   PMID:18660489   PMID:18672804   PMID:18679149   PMID:18689375   PMID:18698203   PMID:18698212  
PMID:18722896   PMID:18758497   PMID:18773126   PMID:18794618   PMID:18797412   PMID:18800139   PMID:18802024   PMID:18830250   PMID:18849600   PMID:18855530   PMID:18856058   PMID:18924534  
PMID:18927546   PMID:18931513   PMID:18945948   PMID:18953568   PMID:18957799   PMID:18971559   PMID:18985387   PMID:19011954   PMID:19021695   PMID:19023100   PMID:19027823   PMID:19057513  
PMID:19059306   PMID:19062524   PMID:19067809   PMID:19071192   PMID:19075095   PMID:19082699   PMID:19086053   PMID:19088254   PMID:19103106   PMID:19105203   PMID:19108684   PMID:19110485  
PMID:19112833   PMID:19126660   PMID:19131662   PMID:19145770   PMID:19150387   PMID:19155782   PMID:19162259   PMID:19164480   PMID:19166692   PMID:19178574   PMID:19183129   PMID:19185300  
PMID:19193863   PMID:19211927   PMID:19225232   PMID:19236533   PMID:19238444   PMID:19242491   PMID:19243623   PMID:19247266   PMID:19254215   PMID:19263529   PMID:19274077   PMID:19286758  
PMID:19288324   PMID:19323983   PMID:19327134   PMID:19332265   PMID:19338750   PMID:19341158   PMID:19365726   PMID:19367093   PMID:19379721   PMID:19397700   PMID:19404196   PMID:19408837  
PMID:19420105   PMID:19463113   PMID:19465003   PMID:19473084   PMID:19473121   PMID:19479237   PMID:19509012   PMID:19520069   PMID:19536167   PMID:19546528   PMID:19550366   PMID:19559392  
PMID:19563532   PMID:19574336   PMID:19578796   PMID:19583994   PMID:19587357   PMID:19620885   PMID:19634497   PMID:19639452   PMID:19650251   PMID:19666008   PMID:19673942   PMID:19681973  
PMID:19708171   PMID:19716087   PMID:19729601   PMID:19729965   PMID:19752885   PMID:19759335   PMID:19770777   PMID:19779330   PMID:19779464   PMID:19782519   PMID:19811349   PMID:19837408  
PMID:19838007   PMID:19853701   PMID:19864304   PMID:19896738   PMID:19898482   PMID:19913121   PMID:19932491   PMID:19948975   PMID:19956635   PMID:20027122   PMID:20029521   PMID:20030467  
PMID:20044471   PMID:20047954   PMID:20066125   PMID:20075747   PMID:20087216   PMID:20142115   PMID:20153828   PMID:20160196   PMID:20161734   PMID:20185782   PMID:20186148   PMID:20216084  
PMID:20223792   PMID:20299978   PMID:20300047   PMID:20308035   PMID:20361261   PMID:20413984   PMID:20414195   PMID:20415212   PMID:20429690   PMID:20431588   PMID:20448352   PMID:20452482  
PMID:20459474   PMID:20478903   PMID:20484657   PMID:20486282   PMID:20525211   PMID:20529973   PMID:20536507   PMID:20537141   PMID:20537417   PMID:20538124   PMID:20547537   PMID:20549134  
PMID:20559404   PMID:20570668   PMID:20577119   PMID:20580725   PMID:20587546   PMID:20592051   PMID:20592241   PMID:20592457   PMID:20594303   PMID:20602615   PMID:20606419   PMID:20615910  
PMID:20628086   PMID:20662730   PMID:20663195   PMID:20663844   PMID:20667857   PMID:20673868   PMID:20674894   PMID:20684663   PMID:20687374   PMID:20703229   PMID:20722844   PMID:20734064  
PMID:20816596   PMID:20824505   PMID:20832068   PMID:20833395   PMID:20854100   PMID:20861465   PMID:20861628   PMID:20876845   PMID:20927107   PMID:20944660   PMID:20945963   PMID:20952631  
PMID:20967221   PMID:20978123   PMID:21095024   PMID:21163122   PMID:21163864   PMID:21183621   PMID:21248783   PMID:21266663   PMID:21306748   PMID:21320707   PMID:21364758   PMID:21436211  
PMID:21438754   PMID:21440764   PMID:21496417   PMID:21500980   PMID:21576655   PMID:21584499   PMID:21628354   PMID:21629041   PMID:21633717   PMID:21636204   PMID:21638051   PMID:21642504  
PMID:21657802   PMID:21659414   PMID:21663700   PMID:21831033   PMID:21873635   PMID:21881578   PMID:21923802   PMID:21988832   PMID:21997900   PMID:22012329   PMID:22057271   PMID:22072715  
PMID:22089112   PMID:22107792   PMID:22146509   PMID:22148914   PMID:22156739   PMID:22156763   PMID:22180785   PMID:22216295   PMID:22248439   PMID:22253417   PMID:22320202   PMID:22323644  
PMID:22371359   PMID:22387727   PMID:22389749   PMID:22399491   PMID:22407459   PMID:22416758   PMID:22475523   PMID:22481164   PMID:22497526   PMID:22513276   PMID:22516433   PMID:22531885  
PMID:22536420   PMID:22549224   PMID:22552372   PMID:22558309   PMID:22570327   PMID:22579612   PMID:22644634   PMID:22664794   PMID:22666926   PMID:22679141   PMID:22684034   PMID:22684035  
PMID:22710764   PMID:22773836   PMID:22791701   PMID:22799745   PMID:22800767   PMID:22842872   PMID:22842919   PMID:22858200   PMID:22881375   PMID:22974788   PMID:23033876   PMID:23056909  
PMID:23065231   PMID:23082758   PMID:23137822   PMID:23151617   PMID:23154270   PMID:23178514   PMID:23261942   PMID:23277274   PMID:23283822   PMID:23283824   PMID:23287839   PMID:23295196  
PMID:23324949   PMID:23345539   PMID:23376485   PMID:23416840   PMID:23438673   PMID:23446738   PMID:23477424   PMID:23480300   PMID:23484199   PMID:23488800   PMID:23497386   PMID:23529640  
PMID:23533145   PMID:23536940   PMID:23541316   PMID:23548909   PMID:23583988   PMID:23587112   PMID:23592589   PMID:23594830   PMID:23597562   PMID:23615648   PMID:23648704   PMID:23666149  
PMID:23707238   PMID:23715995   PMID:23716723   PMID:23722414   PMID:23724017   PMID:23783021   PMID:23790236   PMID:23815626   PMID:23846033   PMID:23860016   PMID:23880184   PMID:23880944  
PMID:23907112   PMID:23933419   PMID:23943853   PMID:24065527   PMID:24068433   PMID:24154707   PMID:24157068   PMID:24164175   PMID:24170657   PMID:24172014   PMID:24178957   PMID:24191285  
PMID:24204726   PMID:24241364   PMID:24284398   PMID:24296617   PMID:24344785   PMID:24452034   PMID:24490766   PMID:24530241   PMID:24572548   PMID:24631685   PMID:24632679   PMID:24667918  
PMID:24694986   PMID:24710077   PMID:24722130   PMID:24728149   PMID:24737640   PMID:24818138   PMID:24965793   PMID:24978482   PMID:25031294   PMID:25036270   PMID:25037231   PMID:25077884  
PMID:25109108   PMID:25143324   PMID:25172907   PMID:25262176   PMID:25302847   PMID:25313067   PMID:25345602   PMID:25350836   PMID:25381307   PMID:25428203   PMID:25523477   PMID:25534858  
PMID:25568318   PMID:25571529   PMID:25660297   PMID:25660845   PMID:25721616   PMID:25804043   PMID:25819272   PMID:25847782   PMID:25867182   PMID:25944852   PMID:25961019   PMID:25966146  
PMID:25968123   PMID:26035976   PMID:26056004   PMID:26092580   PMID:26116142   PMID:26125750   PMID:26142106   PMID:26147666   PMID:26240116   PMID:26305278   PMID:26318936   PMID:26376373  
PMID:26380312   PMID:26388433   PMID:26391364   PMID:26445208   PMID:26482255   PMID:26482465   PMID:26486596   PMID:26489635   PMID:26505451   PMID:26556555   PMID:26588355   PMID:26632605  
PMID:26682227   PMID:26755736   PMID:26772530   PMID:26782563   PMID:26825581   PMID:26840443   PMID:26873967   PMID:26888118   PMID:27014752   PMID:27019433   PMID:27068509   PMID:27085160  
PMID:27119161   PMID:27162064   PMID:27285537   PMID:27310975   PMID:27329205   PMID:27398822   PMID:27432541   PMID:27445100   PMID:27447725   PMID:27586550   PMID:27590243   PMID:27638906  
PMID:27788506   PMID:27801805   PMID:27807688   PMID:27903492   PMID:27910864   PMID:27927648   PMID:27982687   PMID:28004760   PMID:28005267   PMID:28106497   PMID:28119542   PMID:28120210  
PMID:28205588   PMID:28283184   PMID:28302554   PMID:28395289   PMID:28402544   PMID:28467442   PMID:28488548   PMID:28490451   PMID:28514442   PMID:28575445   PMID:28641212   PMID:28712073  
PMID:28747358   PMID:28768720   PMID:28797632   PMID:28798388   PMID:28988519   PMID:29053707   PMID:29277264   PMID:29303211   PMID:29351514   PMID:29366364   PMID:29378484   PMID:29432515  
PMID:29578435   PMID:29674190   PMID:29763087   PMID:29802847   PMID:29984662   PMID:30080282   PMID:30179652   PMID:30340829   PMID:30351652   PMID:30383794   PMID:30389500   PMID:30409744  
PMID:30521887   PMID:30563843   PMID:30700972   PMID:30719178   PMID:30729664   PMID:30798697   PMID:30798724   PMID:30912862   PMID:30915766   PMID:30930452   PMID:31048445   PMID:31061349  
PMID:31084929   PMID:31090060   PMID:31120634   PMID:31142626   PMID:31201268   PMID:31273033   PMID:31379247   PMID:31442828   PMID:31637747   PMID:31836539   PMID:31873176   PMID:32025262  
PMID:32093874   PMID:32242890   PMID:32265040   PMID:32344395   PMID:32356512   PMID:32535722   PMID:32572956   PMID:32640904   PMID:32667032   PMID:32673509   PMID:32679678   PMID:32741247  
PMID:32751352   PMID:32814053   PMID:32871819   PMID:32873146   PMID:32880990   PMID:33173183   PMID:33223956   PMID:33230614   PMID:33231620   PMID:33302801   PMID:33309638   PMID:33423909  
PMID:33459093   PMID:33461312   PMID:33480126   PMID:33511992   PMID:33612680   PMID:33657582   PMID:33668947   PMID:33961781   PMID:34025779   PMID:34107716   PMID:34240732   PMID:34275374  
PMID:34285710   PMID:34499692   PMID:34570572   PMID:34603502   PMID:34655849   PMID:34732716   PMID:34757767   PMID:34758666   PMID:34793856   PMID:34798372   PMID:34860335   PMID:34933429  
PMID:34952427   PMID:35030476   PMID:35317386   PMID:35328506   PMID:35458690   PMID:35696571   PMID:36018774   PMID:36042680   PMID:36174930   PMID:36215168   PMID:36360218   PMID:36421822  
PMID:36478297   PMID:36481346   PMID:36525166   PMID:36598307   PMID:36853865   PMID:36999649   PMID:37455529   PMID:37460637   PMID:37802686   PMID:37909169   PMID:37922976   PMID:38061470  
PMID:38105755   PMID:38265173   PMID:38279313   PMID:38380450   PMID:38489704   PMID:38492325   PMID:38622720  


Genomics

Comparative Map Data
AGT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381230,702,523 - 230,745,583 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1230,690,776 - 230,745,576 (-)EnsemblGRCh38hg38GRCh38
GRCh371230,838,269 - 230,881,329 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361228,904,892 - 228,916,564 (-)NCBINCBI36Build 36hg18NCBI36
Build 341227,145,019 - 227,156,602NCBI
Celera1204,104,291 - 204,116,358 (-)NCBICelera
Cytogenetic Map1q42.2NCBI
HuRef1201,323,209 - 201,335,277 (-)NCBIHuRef
CHM1_11232,111,282 - 232,123,349 (-)NCBICHM1_1
T2T-CHM13v2.01230,083,077 - 230,126,137 (-)NCBIT2T-CHM13v2.0
Agt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398125,283,326 - 125,296,445 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8125,283,273 - 125,296,445 (-)EnsemblGRCm39 Ensembl
GRCm388124,556,587 - 124,569,706 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8124,556,534 - 124,569,706 (-)EnsemblGRCm38mm10GRCm38
MGSCv378127,080,487 - 127,093,607 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368127,442,677 - 127,455,773 (-)NCBIMGSCv36mm8
Celera8128,860,995 - 128,873,954 (-)NCBICelera
Cytogenetic Map8E2NCBI
cM Map872.81NCBI
Agt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81969,426,540 - 69,447,017 (-)NCBIGRCr8
mRatBN7.21952,529,139 - 52,549,618 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1952,529,185 - 52,540,977 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1959,313,724 - 59,325,510 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01960,165,792 - 60,177,589 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01962,240,179 - 62,251,965 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01957,321,594 - 57,333,460 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1957,321,640 - 57,333,433 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01968,026,182 - 68,038,550 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41954,738,556 - 54,750,349 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11954,743,436 - 54,755,230 (-)NCBI
Celera1951,899,180 - 51,910,819 (-)NCBICelera
Cytogenetic Map19q12NCBI
Agt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554927,866,833 - 7,873,357 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554927,863,662 - 7,874,863 (+)NCBIChiLan1.0ChiLan1.0
AGT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2118,492,156 - 18,503,638 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1118,684,644 - 18,696,136 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01206,252,141 - 206,263,830 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11211,279,015 - 211,291,044 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1211,279,015 - 211,291,044 (-)Ensemblpanpan1.1panPan2
AGT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.148,681,192 - 8,694,059 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl48,683,798 - 8,693,880 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha48,672,874 - 8,685,743 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.048,705,485 - 8,718,357 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl48,705,603 - 8,718,382 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.148,709,653 - 8,722,523 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.048,831,567 - 8,844,457 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.049,061,768 - 9,074,658 (+)NCBIUU_Cfam_GSD_1.0
Agt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934443,547,972 - 43,555,916 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648419,716,165 - 19,721,261 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648419,713,299 - 19,721,144 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AGT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1459,643,292 - 59,656,833 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11459,643,030 - 59,656,835 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21464,380,799 - 64,385,995 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AGT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12567,964,840 - 67,977,006 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2567,962,401 - 67,973,324 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605569,870,396 - 69,882,850 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Agt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477518,849,118 - 18,855,577 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477518,846,222 - 18,856,093 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in AGT
185 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_000029.4(AGT):c.803T>C (p.Met268Thr) single nucleotide variant Hypertension, essential, susceptibility to [RCV000019691]|Hypertensive disorder [RCV002259306]|Preeclampsia, susceptibility to [RCV000019692]|Renal tubular dysgenesis [RCV000405686]|Susceptibility to progression to renal failure in IgA nephropathy [RCV000019693]|not provided [RCV000835695]|not specified [RCV000242838] Chr1:230710048 [GRCh38]
Chr1:230845794 [GRCh37]
Chr1:1q42.2
risk factor|benign
AGT, -6A HAPLOTYPE single nucleotide variant Crohn disease, association with [RCV000019695]|Hypertension, essential, susceptibility to [RCV000019694] Chr1:1q42-q43 pathogenic|risk factor
NM_000029.4(AGT):c.1124G>A (p.Arg375Gln) single nucleotide variant Renal tubular dysgenesis [RCV000019696] Chr1:230705933 [GRCh38]
Chr1:230841679 [GRCh37]
Chr1:1q42.2
pathogenic
NM_000029.4(AGT):c.604C>T (p.Gln202Ter) single nucleotide variant Renal tubular dysgenesis [RCV000019697] Chr1:230710247 [GRCh38]
Chr1:230845993 [GRCh37]
Chr1:1q42.2
pathogenic
NM_000029.4(AGT):c.1290del (p.Phe430fs) deletion Renal tubular dysgenesis [RCV000019698] Chr1:230703309 [GRCh38]
Chr1:230839055 [GRCh37]
Chr1:1q42.2
pathogenic
NM_001384479.1(AGT):c.374T>C single nucleotide variant Essential hypertension, genetic [RCV002507273]|not provided [RCV000722543] Chr1:230710450 [GRCh38]
Chr1:230846196 [GRCh37]
Chr1:1q42.2
uncertain significance
GRCh38/hg38 1q42.2(chr1:230519755-231232066)x3 copy number gain See cases [RCV000050291] Chr1:230519755..231232066 [GRCh38]
Chr1:230655501..231367812 [GRCh37]
Chr1:228722124..229434435 [NCBI36]
Chr1:1q42.2
uncertain significance
GRCh38/hg38 1q32.3-44(chr1:214023812-248918469)x3 copy number gain See cases [RCV000050981] Chr1:214023812..248918469 [GRCh38]
Chr1:214197155..249212668 [GRCh37]
Chr1:212263778..247179291 [NCBI36]
Chr1:1q32.3-44
pathogenic
GRCh38/hg38 1q41-44(chr1:223347693-248918469)x3 copy number gain See cases [RCV000050581] Chr1:223347693..248918469 [GRCh38]
Chr1:223521035..249212668 [GRCh37]
Chr1:221587658..247179291 [NCBI36]
Chr1:1q41-44
pathogenic
GRCh38/hg38 1q42.13-42.2(chr1:229883805-231517553)x3 copy number gain See cases [RCV000051559] Chr1:229883805..231517553 [GRCh38]
Chr1:230019552..231653299 [GRCh37]
Chr1:228086175..229719922 [NCBI36]
Chr1:1q42.13-42.2
uncertain significance
GRCh38/hg38 1q42.13-42.2(chr1:230489657-231243203)x3 copy number gain See cases [RCV000051560] Chr1:230489657..231243203 [GRCh38]
Chr1:230625403..231378949 [GRCh37]
Chr1:228692026..229445572 [NCBI36]
Chr1:1q42.13-42.2
uncertain significance
GRCh38/hg38 1q42.13-44(chr1:230106271-243677283)x1 copy number loss See cases [RCV000051082] Chr1:230106271..243677283 [GRCh38]
Chr1:230242018..243840585 [GRCh37]
Chr1:228308641..241907208 [NCBI36]
Chr1:1q42.13-44
pathogenic
GRCh38/hg38 1q41-44(chr1:221902539-248918469)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051875]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051875]|See cases [RCV000051875] Chr1:221902539..248918469 [GRCh38]
Chr1:222075881..249212668 [GRCh37]
Chr1:220142504..247179291 [NCBI36]
Chr1:1q41-44
pathogenic
GRCh38/hg38 1q41-44(chr1:223828500-248891309)x3 copy number gain See cases [RCV000051878] Chr1:223828500..248891309 [GRCh38]
Chr1:224016202..249185508 [GRCh37]
Chr1:222082825..247152131 [NCBI36]
Chr1:1q41-44
pathogenic
GRCh38/hg38 1q41-44(chr1:223887780-248891309)x3 copy number gain See cases [RCV000051880] Chr1:223887780..248891309 [GRCh38]
Chr1:224075482..249185508 [GRCh37]
Chr1:222142105..247152131 [NCBI36]
Chr1:1q41-44
pathogenic
GRCh38/hg38 1q32.2-44(chr1:209646207-248931113)x3 copy number gain See cases [RCV000051861] Chr1:209646207..248931113 [GRCh38]
Chr1:209819552..249225312 [GRCh37]
Chr1:207886175..247191935 [NCBI36]
Chr1:1q32.2-44
pathogenic
GRCh38/hg38 1q42.11-44(chr1:224096488-248918469)x3 copy number gain See cases [RCV000051882] Chr1:224096488..248918469 [GRCh38]
Chr1:224284190..249212668 [GRCh37]
Chr1:222350813..247179291 [NCBI36]
Chr1:1q42.11-44
pathogenic
GRCh38/hg38 1q42.2(chr1:230693760-230780212)x1 copy number loss See cases [RCV000053984] Chr1:230693760..230780212 [GRCh38]
Chr1:230829506..230915958 [GRCh37]
Chr1:228896129..228982581 [NCBI36]
Chr1:1q42.2
pathogenic
NM_000029.4(AGT):c.1429C>T (p.Arg477Cys) single nucleotide variant not provided [RCV002795451] Chr1:230703170 [GRCh38]
Chr1:230838916 [GRCh37]
Chr1:228905539 [NCBI36]
Chr1:1q42.2
uncertain significance|not provided
GRCh38/hg38 1q32.2-44(chr1:209963625-248918469)x3 copy number gain See cases [RCV000134979] Chr1:209963625..248918469 [GRCh38]
Chr1:210136970..249212668 [GRCh37]
Chr1:208203593..247179291 [NCBI36]
Chr1:1q32.2-44
pathogenic
GRCh38/hg38 1q41-44(chr1:223815147-248918469)x3 copy number gain See cases [RCV000135839] Chr1:223815147..248918469 [GRCh38]
Chr1:224002849..249212668 [GRCh37]
Chr1:222069472..247179291 [NCBI36]
Chr1:1q41-44
pathogenic
GRCh38/hg38 1q42.12-42.2(chr1:226185124-232872488)x1 copy number loss See cases [RCV000135796] Chr1:226185124..232872488 [GRCh38]
Chr1:226372825..233008234 [GRCh37]
Chr1:224439448..231074857 [NCBI36]
Chr1:1q42.12-42.2
pathogenic
GRCh38/hg38 1q42.13-44(chr1:229022909-248918469)x3 copy number gain See cases [RCV000136666] Chr1:229022909..248918469 [GRCh38]
Chr1:229158656..249212668 [GRCh37]
Chr1:227225279..247179291 [NCBI36]
Chr1:1q42.13-44
pathogenic
GRCh38/hg38 1q42.11-44(chr1:224022862-248918469)x3 copy number gain See cases [RCV000137769] Chr1:224022862..248918469 [GRCh38]
Chr1:224210564..249212668 [GRCh37]
Chr1:222277187..247179291 [NCBI36]
Chr1:1q42.11-44
pathogenic
GRCh38/hg38 1q42.12-44(chr1:225438480-248787200)x3 copy number gain See cases [RCV000142448] Chr1:225438480..248787200 [GRCh38]
Chr1:225626182..249060210 [GRCh37]
Chr1:223692805..247048022 [NCBI36]
Chr1:1q42.12-44
pathogenic
GRCh38/hg38 1q32.2-44(chr1:207346642-248930485)x3 copy number gain See cases [RCV000143727] Chr1:207346642..248930485 [GRCh38]
Chr1:207519987..249224684 [GRCh37]
Chr1:205586610..247191307 [NCBI36]
Chr1:1q32.2-44
pathogenic
GRCh38/hg38 1q42.2(chr1:230519755-231232066)x3 copy number gain See cases [RCV000148222] Chr1:230519755..231232066 [GRCh38]
Chr1:230655501..231367812 [GRCh37]
Chr1:228722124..229434435 [NCBI36]
Chr1:1q42.2
uncertain significance
NM_000029.4(AGT):c.886G>A (p.Glu296Lys) single nucleotide variant Renal tubular dysgenesis [RCV000407068]|not provided [RCV002059455] Chr1:230706171 [GRCh38]
Chr1:230841917 [GRCh37]
Chr1:1q42.2
benign|uncertain significance
NM_001382817.3(AGT):c.-30-3273G>A single nucleotide variant Crohn disease, association with [RCV002221222]|Hypertension, essential, susceptibility to [RCV002221221]|Renal tubular dysgenesis [RCV000262949]|not provided [RCV000835696] Chr1:230714126 [GRCh38]
Chr1:230849872 [GRCh37]
Chr1:1q42.2
pathogenic|risk factor|benign
NM_000029.4(AGT):c.1345C>G (p.Pro449Ala) single nucleotide variant Renal tubular dysgenesis [RCV000273592] Chr1:230703254 [GRCh38]
Chr1:230839000 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_000029.4(AGT):c.1154T>C (p.Val385Ala) single nucleotide variant AGT-related disorder [RCV003930230]|Renal tubular dysgenesis [RCV000280174]|not provided [RCV000894534] Chr1:230704308 [GRCh38]
Chr1:230840054 [GRCh37]
Chr1:1q42.2
likely benign|uncertain significance
NM_000029.4(AGT):c.951C>T (p.Gly317=) single nucleotide variant Essential hypertension, genetic [RCV002494921]|Renal tubular dysgenesis [RCV000281333]|not provided [RCV002520454] Chr1:230706106 [GRCh38]
Chr1:230841852 [GRCh37]
Chr1:1q42.2
likely benign|uncertain significance
NM_000029.4(AGT):c.412G>T (p.Ala138Ser) single nucleotide variant Essential hypertension, genetic [RCV002487312]|Renal tubular dysgenesis [RCV000272090]|not provided [RCV002520456] Chr1:230710439 [GRCh38]
Chr1:230846185 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_000029.4(AGT):c.620C>T (p.Thr207Met) single nucleotide variant Renal tubular dysgenesis [RCV000366681]|not provided [RCV001651343] Chr1:230710231 [GRCh38]
Chr1:230845977 [GRCh37]
Chr1:1q42.2
benign|likely benign
NM_000029.4(AGT):c.883G>T (p.Ala295Ser) single nucleotide variant Renal tubular dysgenesis [RCV000306174] Chr1:230706174 [GRCh38]
Chr1:230841920 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_001384479.1(AGT):c.647A>C single nucleotide variant Essential hypertension, genetic [RCV002487311]|Renal tubular dysgenesis [RCV000307338]|not provided [RCV002520455] Chr1:230710177 [GRCh38]
Chr1:230845923 [GRCh37]
Chr1:1q42.2
likely benign|uncertain significance
NM_000029.4(AGT):c.1125-13A>G single nucleotide variant Renal tubular dysgenesis [RCV000335269]|not provided [RCV001718596] Chr1:230704350 [GRCh38]
Chr1:230840096 [GRCh37]
Chr1:1q42.2
benign
NM_000029.4(AGT):c.151T>C (p.Cys51Arg) single nucleotide variant AGT-related disorder [RCV003930231]|Renal tubular dysgenesis [RCV000332892]|not provided [RCV000963786]|not specified [RCV001357255] Chr1:230710700 [GRCh38]
Chr1:230846446 [GRCh37]
Chr1:1q42.2
benign|likely benign|uncertain significance
NM_001384479.1(AGT):c.1298C>T single nucleotide variant AGT-related disorder [RCV003967839]|Essential hypertension, genetic [RCV002502175]|Renal tubular dysgenesis [RCV000333287]|not provided [RCV000888640] Chr1:230703274 [GRCh38]
Chr1:230839020 [GRCh37]
Chr1:1q42.2
likely benign|uncertain significance
NM_000029.4(AGT):c.891C>T (p.Pro297=) single nucleotide variant Renal tubular dysgenesis [RCV000341129] Chr1:230706166 [GRCh38]
Chr1:230841912 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_000029.4(AGT):c.843C>T (p.Tyr281=) single nucleotide variant AGT-related disorder [RCV003949983]|Renal tubular dysgenesis [RCV000342352] Chr1:230710008 [GRCh38]
Chr1:230845754 [GRCh37]
Chr1:1q42.2
likely benign|uncertain significance
NM_000029.4(AGT):c.1116A>G (p.Leu372=) single nucleotide variant Essential hypertension, genetic [RCV002500843]|Renal tubular dysgenesis [RCV000375752]|not provided [RCV001668403]|not specified [RCV000250884] Chr1:230705941 [GRCh38]
Chr1:230841687 [GRCh37]
Chr1:1q42.2
benign|likely benign
NM_000029.4(AGT):c.*287G>A single nucleotide variant Renal tubular dysgenesis [RCV000272426] Chr1:230702854 [GRCh38]
Chr1:230838600 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_001382817.3(AGT):c.-30-3287A>C single nucleotide variant Renal tubular dysgenesis [RCV000377471]|not provided [RCV001651344] Chr1:230714140 [GRCh38]
Chr1:230849886 [GRCh37]
Chr1:1q42.2
benign|likely benign
NM_000029.4(AGT):c.*514G>A single nucleotide variant Renal tubular dysgenesis [RCV000301934] Chr1:230702627 [GRCh38]
Chr1:230838373 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_001382817.3(AGT):c.-30-3451G>A single nucleotide variant Renal tubular dysgenesis [RCV000288780] Chr1:230714304 [GRCh38]
Chr1:230850050 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_001382817.3(AGT):c.-30-3419G>A single nucleotide variant Renal tubular dysgenesis [RCV000342647] Chr1:230714272 [GRCh38]
Chr1:230850018 [GRCh37]
Chr1:1q42.2
likely benign
NM_000029.4(AGT):c.*423T>G single nucleotide variant Renal tubular dysgenesis [RCV000307627] Chr1:230702718 [GRCh38]
Chr1:230838464 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_001382817.3(AGT):c.-30-3484G>A single nucleotide variant Renal tubular dysgenesis [RCV000343947]|not provided [RCV001723880] Chr1:230714337 [GRCh38]
Chr1:230850083 [GRCh37]
Chr1:1q42.2
benign
NM_001382817.3(AGT):c.-30-3549C>T single nucleotide variant Renal tubular dysgenesis [RCV000308977] Chr1:230714402 [GRCh38]
Chr1:230850148 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_000029.4(AGT):c.*167T>C single nucleotide variant Renal tubular dysgenesis [RCV000327527] Chr1:230702974 [GRCh38]
Chr1:230838720 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_000029.4(AGT):c.*556C>A single nucleotide variant Renal tubular dysgenesis [RCV000390829] Chr1:230702585 [GRCh38]
Chr1:230838331 [GRCh37]
Chr1:1q42.2
benign
NM_001382817.3(AGT):c.-30-3652G>A single nucleotide variant Renal tubular dysgenesis [RCV000392018] Chr1:230714505 [GRCh38]
Chr1:230850251 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_001382817.3(AGT):c.-30-3527G>A single nucleotide variant Renal tubular dysgenesis [RCV000392035] Chr1:230714380 [GRCh38]
Chr1:230850126 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_001382817.3(AGT):c.-30-3629T>C single nucleotide variant Renal tubular dysgenesis [RCV000349786] Chr1:230714482 [GRCh38]
Chr1:230850228 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_000029.4(AGT):c.-29C>T single nucleotide variant Renal tubular dysgenesis [RCV000371624] Chr1:230714111 [GRCh38]
Chr1:230849857 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_001382817.3(AGT):c.-30-3415G>A single nucleotide variant Renal tubular dysgenesis [RCV000283004] Chr1:230714268 [GRCh38]
Chr1:230850014 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_000029.4(AGT):c.*508C>T single nucleotide variant Renal tubular dysgenesis [RCV000266691] Chr1:230702633 [GRCh38]
Chr1:230838379 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_000029.4(AGT):c.263T>C (p.Leu88Pro) single nucleotide variant Renal tubular dysgenesis [RCV000277902] Chr1:230710588 [GRCh38]
Chr1:230846334 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_000029.4(AGT):c.*384A>C single nucleotide variant Renal tubular dysgenesis [RCV000362285] Chr1:230702757 [GRCh38]
Chr1:230838503 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_001382817.3(AGT):c.-30-3277G>A single nucleotide variant Renal tubular dysgenesis [RCV000318145] Chr1:230714130 [GRCh38]
Chr1:230849876 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_000029.4(AGT):c.274G>A (p.Ala92Thr) single nucleotide variant Inborn genetic diseases [RCV004021429]|Renal tubular dysgenesis [RCV000367752]|not provided [RCV002520457] Chr1:230710577 [GRCh38]
Chr1:230846323 [GRCh37]
Chr1:1q42.2
likely benign|uncertain significance
NM_000029.4(AGT):c.*83G>A single nucleotide variant Renal tubular dysgenesis [RCV000386467] Chr1:230703058 [GRCh38]
Chr1:230838804 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_000029.4(AGT):c.1222G>A (p.Glu408Lys) single nucleotide variant Renal tubular dysgenesis [RCV000387779] Chr1:230704240 [GRCh38]
Chr1:230839986 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_000029.3(AGT):c.*629C>T single nucleotide variant Renal tubular dysgenesis [RCV000382965] Chr1:230702512 [GRCh38]
Chr1:230838258 [GRCh37]
Chr1:1q42.2
benign
NM_000029.4(AGT):c.327G>A (p.Leu109=) single nucleotide variant Renal tubular dysgenesis [RCV000313046] Chr1:230710524 [GRCh38]
Chr1:230846270 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_000029.4(AGT):c.*513C>A single nucleotide variant Renal tubular dysgenesis [RCV000361239] Chr1:230702628 [GRCh38]
Chr1:230838374 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_001382817.3(AGT):c.-30-3420C>T single nucleotide variant Renal tubular dysgenesis [RCV000378541] Chr1:230714273 [GRCh38]
Chr1:230850019 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_000029.4(AGT):c.499_512dup (p.Cys171Ter) duplication not provided [RCV000722746] Chr1:230710338..230710339 [GRCh38]
Chr1:230846084..230846085 [GRCh37]
Chr1:1q42.2
uncertain significance
GRCh37/hg19 1q31.3-44(chr1:195483439-249213000)x3 copy number gain See cases [RCV000449172] Chr1:195483439..249213000 [GRCh37]
Chr1:1q31.3-44
pathogenic
GRCh37/hg19 1q41-44(chr1:214697099-249224684)x3 copy number gain See cases [RCV000449210] Chr1:214697099..249224684 [GRCh37]
Chr1:1q41-44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
NM_001384479.1(AGT):c.829+1G>T single nucleotide variant Essential hypertension, genetic [RCV002489210]|not provided [RCV000493969] Chr1:230709994 [GRCh38]
Chr1:230845740 [GRCh37]
Chr1:1q42.2
pathogenic|likely pathogenic
NM_001384479.1(AGT):c.1060C>T single nucleotide variant Essential hypertension, genetic [RCV002496897]|not provided [RCV000492929] Chr1:230705970 [GRCh38]
Chr1:230841716 [GRCh37]
Chr1:1q42.2
pathogenic|likely pathogenic
GRCh37/hg19 1q42.13-42.2(chr1:230619349-231413907)x3 copy number gain See cases [RCV000511859] Chr1:230619349..231413907 [GRCh37]
Chr1:1q42.13-42.2
uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1q42.11-44(chr1:224105294-249224684)x3 copy number gain See cases [RCV000510981] Chr1:224105294..249224684 [GRCh37]
Chr1:1q42.11-44
pathogenic
NM_001384479.1(AGT):c.234G>T (p.Gln78His) single nucleotide variant Inborn genetic diseases [RCV003240052] Chr1:230710590 [GRCh38]
Chr1:230846336 [GRCh37]
Chr1:1q42.2
uncertain significance
GRCh37/hg19 1q41-44(chr1:218252551-249224684)x3 copy number gain not provided [RCV000684700] Chr1:218252551..249224684 [GRCh37]
Chr1:1q41-44
pathogenic
GRCh37/hg19 1q42.13-44(chr1:228529973-249181598)x3 copy number gain not provided [RCV000684707] Chr1:228529973..249181598 [GRCh37]
Chr1:1q42.13-44
pathogenic
NM_001384479.1(AGT):c.161_162delinsT (p.Lys54fs) indel Large fontanelles [RCV001807655] Chr1:230710662..230710663 [GRCh38]
Chr1:230846408..230846409 [GRCh37]
Chr1:1q42.2
likely pathogenic
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44
pathogenic
NM_001384479.1(AGT):c.282C>T single nucleotide variant Essential hypertension, genetic [RCV002502625]|not provided [RCV000896893] Chr1:230710542 [GRCh38]
Chr1:230846288 [GRCh37]
Chr1:1q42.2
likely benign
NM_001384479.1(AGT):c.1097+170T>C single nucleotide variant not provided [RCV001707021] Chr1:230705763 [GRCh38]
Chr1:230841509 [GRCh37]
Chr1:1q42.2
benign
NM_001384479.1(AGT):c.829+186C>T single nucleotide variant not provided [RCV001610221] Chr1:230709809 [GRCh38]
Chr1:230845555 [GRCh37]
Chr1:1q42.2
benign
NM_000029.4(AGT):c.567C>T (p.Gly189=) single nucleotide variant not provided [RCV000923506] Chr1:230710284 [GRCh38]
Chr1:230846030 [GRCh37]
Chr1:1q42.2
benign
NM_000029.4(AGT):c.912C>T (p.Asn304=) single nucleotide variant Essential hypertension, genetic [RCV002502676]|Renal tubular dysgenesis [RCV001098336]|not provided [RCV000903072] Chr1:230706145 [GRCh38]
Chr1:230841891 [GRCh37]
Chr1:1q42.2
benign|likely benign
NM_001384479.1(AGT):c.363G>A single nucleotide variant Essential hypertension, genetic [RCV002487998]|not provided [RCV000922423] Chr1:230710461 [GRCh38]
Chr1:230846207 [GRCh37]
Chr1:1q42.2
likely benign
NM_000029.4(AGT):c.39C>T (p.Ala13=) single nucleotide variant not provided [RCV000919514] Chr1:230710812 [GRCh38]
Chr1:230846558 [GRCh37]
Chr1:1q42.2
likely benign
NM_000029.4(AGT):c.198C>A (p.Thr66=) single nucleotide variant not provided [RCV000940446] Chr1:230710653 [GRCh38]
Chr1:230846399 [GRCh37]
Chr1:1q42.2
likely benign
NM_000029.4(AGT):c.1125-10A>G single nucleotide variant not provided [RCV000918472] Chr1:230704347 [GRCh38]
Chr1:230840093 [GRCh37]
Chr1:1q42.2
likely benign
NM_000029.4(AGT):c.1395T>C (p.Tyr465=) single nucleotide variant Essential hypertension, genetic [RCV002487940]|not provided [RCV000885589] Chr1:230703204 [GRCh38]
Chr1:230838950 [GRCh37]
Chr1:1q42.2
likely benign
NM_000029.4(AGT):c.1023C>T (p.Cys341=) single nucleotide variant Renal tubular dysgenesis [RCV001096605]|not provided [RCV000894304] Chr1:230706034 [GRCh38]
Chr1:230841780 [GRCh37]
Chr1:1q42.2
benign
NM_000029.4(AGT):c.1018G>A (p.Ala340Thr) single nucleotide variant Renal tubular dysgenesis [RCV001096606] Chr1:230706039 [GRCh38]
Chr1:230841785 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_000029.4(AGT):c.1071G>T (p.Glu357Asp) single nucleotide variant Renal tubular dysgenesis [RCV001096602] Chr1:230705986 [GRCh38]
Chr1:230841732 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_001384479.1(AGT):c.1027G>A single nucleotide variant Essential hypertension, genetic [RCV002489740]|Renal tubular dysgenesis [RCV001096603]|not provided [RCV002555985] Chr1:230706003 [GRCh38]
Chr1:230841749 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_000029.4(AGT):c.*226T>C single nucleotide variant Renal tubular dysgenesis [RCV001098249] Chr1:230702915 [GRCh38]
Chr1:230838661 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_000029.4(AGT):c.1050C>G (p.Ala350=) single nucleotide variant not provided [RCV000980303] Chr1:230706007 [GRCh38]
Chr1:230841753 [GRCh37]
Chr1:1q42.2
likely benign
GRCh37/hg19 1q25.3-44(chr1:182388773-249111240)x3 copy number gain not provided [RCV000845852] Chr1:182388773..249111240 [GRCh37]
Chr1:1q25.3-44
pathogenic
GRCh37/hg19 1q42.13-43(chr1:228832737-240993877)x3 copy number gain not provided [RCV001005187] Chr1:228832737..240993877 [GRCh37]
Chr1:1q42.13-43
pathogenic
NM_000029.4(AGT):c.1053T>C (p.Ser351=) single nucleotide variant Renal tubular dysgenesis [RCV001096604] Chr1:230706004 [GRCh38]
Chr1:230841750 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_001384479.1(AGT):c.77G>A (p.Arg26Gln) single nucleotide variant Renal tubular dysgenesis [RCV001175178] Chr1:230710747 [GRCh38]
Chr1:230846493 [GRCh37]
Chr1:1q42.2
likely pathogenic
NM_000029.4(AGT):c.1301C>T (p.Ala434Val) single nucleotide variant Essential hypertension, genetic [RCV002482181]|Renal tubular dysgenesis [RCV001102003] Chr1:230703298 [GRCh38]
Chr1:230839044 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_000029.4(AGT):c.28A>T (p.Met10Leu) single nucleotide variant Renal tubular dysgenesis [RCV001102123]|not provided [RCV003558668] Chr1:230710823 [GRCh38]
Chr1:230846569 [GRCh37]
Chr1:1q42.2
likely benign
GRCh37/hg19 1q41-43(chr1:219916966-239004378)x3 copy number gain not provided [RCV001005175] Chr1:219916966..239004378 [GRCh37]
Chr1:1q41-43
pathogenic
NM_001384479.1(AGT):c.53G>A (p.Trp18Ter) single nucleotide variant not provided [RCV003106689] Chr1:230710771 [GRCh38]
Chr1:230846517 [GRCh37]
Chr1:1q42.2
pathogenic
NM_001384479.1(AGT):c.-30-244G>A single nucleotide variant not provided [RCV001617770] Chr1:230711097 [GRCh38]
Chr1:230846843 [GRCh37]
Chr1:1q42.2
benign
NM_001384479.1(AGT):c.1098-186T>C single nucleotide variant not provided [RCV001615895] Chr1:230704523 [GRCh38]
Chr1:230840269 [GRCh37]
Chr1:1q42.2
benign
NM_001384479.1(AGT):c.-30-80A>G single nucleotide variant not provided [RCV001649655] Chr1:230710933 [GRCh38]
Chr1:230846679 [GRCh37]
Chr1:1q42.2
benign
NM_001384479.1(AGT):c.1097+118C>T single nucleotide variant not provided [RCV001614362] Chr1:230705815 [GRCh38]
Chr1:230841561 [GRCh37]
Chr1:1q42.2
benign
NM_001384479.1(AGT):c.-31+1130G>A single nucleotide variant not provided [RCV001670960] Chr1:230712956 [GRCh38]
Chr1:230848702 [GRCh37]
Chr1:1q42.2
benign
NM_000029.4(AGT):c.292G>A (p.Glu98Lys) single nucleotide variant AGT-related disorder [RCV003960791]|not provided [RCV000967941] Chr1:230710559 [GRCh38]
Chr1:230846305 [GRCh37]
Chr1:1q42.2
benign
NM_000029.4(AGT):c.1442C>T (p.Pro481Leu) single nucleotide variant Renal tubular dysgenesis [RCV001100025]|not provided [RCV000974896] Chr1:230703157 [GRCh38]
Chr1:230838903 [GRCh37]
Chr1:1q42.2
likely benign
NM_000029.4(AGT):c.984C>T (p.Asn328=) single nucleotide variant not provided [RCV000926763] Chr1:230706073 [GRCh38]
Chr1:230841819 [GRCh37]
Chr1:1q42.2
likely benign
NM_000029.4(AGT):c.410C>T (p.Thr137Met) single nucleotide variant AGT-related disorder [RCV003923089]|Essential hypertension, genetic [RCV002502705]|Renal tubular dysgenesis [RCV001100122]|not provided [RCV000906753] Chr1:230710441 [GRCh38]
Chr1:230846187 [GRCh37]
Chr1:1q42.2
benign|likely benign
NM_000029.4(AGT):c.*158C>G single nucleotide variant Renal tubular dysgenesis [RCV001100023] Chr1:230702983 [GRCh38]
Chr1:230838729 [GRCh37]
Chr1:1q42.2
benign
NM_000029.4(AGT):c.*614A>G single nucleotide variant Renal tubular dysgenesis [RCV001096498] Chr1:230702527 [GRCh38]
Chr1:230838273 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_000029.4(AGT):c.696T>C (p.Pro232=) single nucleotide variant Renal tubular dysgenesis [RCV001100121]|not provided [RCV000913365] Chr1:230710155 [GRCh38]
Chr1:230845901 [GRCh37]
Chr1:1q42.2
likely benign|uncertain significance
NM_001384479.1(AGT):c.906C>A single nucleotide variant AGT-related disorder [RCV003895690]|Essential hypertension, genetic [RCV002489248]|not provided [RCV000935963] Chr1:230706124 [GRCh38]
Chr1:230841870 [GRCh37]
Chr1:1q42.2
likely benign
NM_000029.4(AGT):c.396C>T (p.Thr132=) single nucleotide variant Essential hypertension, genetic [RCV002479048]|not provided [RCV000911274] Chr1:230710455 [GRCh38]
Chr1:230846201 [GRCh37]
Chr1:1q42.2
likely benign
NM_001384479.1(AGT):c.862C>T single nucleotide variant Essential hypertension, genetic [RCV002489485]|not provided [RCV000994282] Chr1:230706168 [GRCh38]
Chr1:230841914 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_001384479.1(AGT):c.1098-114G>T single nucleotide variant not provided [RCV001688925] Chr1:230704451 [GRCh38]
Chr1:230840197 [GRCh37]
Chr1:1q42.2
benign
GRCh37/hg19 1q42.13-42.2(chr1:230616084-231410027)x3 copy number gain not provided [RCV001005189] Chr1:230616084..231410027 [GRCh37]
Chr1:1q42.13-42.2
uncertain significance
GRCh37/hg19 1q41-42.2(chr1:223653722-234591807)x1 copy number loss not provided [RCV001005180] Chr1:223653722..234591807 [GRCh37]
Chr1:1q41-42.2
pathogenic
GRCh37/hg19 1q32.2-44(chr1:210152794-249218992)x3 copy number gain See cases [RCV001194578] Chr1:210152794..249218992 [GRCh37]
Chr1:1q32.2-44
pathogenic
NM_000029.4(AGT):c.127C>T (p.Leu43Phe) single nucleotide variant Renal tubular dysgenesis [RCV001102121]|not provided [RCV001759868] Chr1:230710724 [GRCh38]
Chr1:230846470 [GRCh37]
Chr1:1q42.2
conflicting interpretations of pathogenicity|uncertain significance
NM_001384479.1(AGT):c.31A>C single nucleotide variant Essential hypertension, genetic [RCV002482182]|Renal tubular dysgenesis [RCV001102122] Chr1:230710793 [GRCh38]
Chr1:230846539 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_000029.4(AGT):c.1233G>T (p.Leu411=) single nucleotide variant AGT-related disorder [RCV003953472]|Renal tubular dysgenesis [RCV001102005]|not provided [RCV003413913] Chr1:230704229 [GRCh38]
Chr1:230839975 [GRCh37]
Chr1:1q42.2
benign|likely benign|uncertain significance
NM_000029.4(AGT):c.148A>T (p.Thr50Ser) single nucleotide variant Renal tubular dysgenesis [RCV001102120]|not provided [RCV002069709] Chr1:230710703 [GRCh38]
Chr1:230846449 [GRCh37]
Chr1:1q42.2
benign|uncertain significance
NM_000029.4(AGT):c.*211C>T single nucleotide variant Renal tubular dysgenesis [RCV001100021] Chr1:230702930 [GRCh38]
Chr1:230838676 [GRCh37]
Chr1:1q42.2
likely benign
NM_000029.4(AGT):c.*159G>A single nucleotide variant Renal tubular dysgenesis [RCV001100022] Chr1:230702982 [GRCh38]
Chr1:230838728 [GRCh37]
Chr1:1q42.2
likely benign
NM_000029.4(AGT):c.*40C>T single nucleotide variant Renal tubular dysgenesis [RCV001100024] Chr1:230703101 [GRCh38]
Chr1:230838847 [GRCh37]
Chr1:1q42.2
likely benign
GRCh37/hg19 1q32.1-44(chr1:204045948-249218992)x3 copy number gain See cases [RCV001007407] Chr1:204045948..249218992 [GRCh37]
Chr1:1q32.1-44
pathogenic
NM_000029.4(AGT):c.772G>A (p.Val258Met) single nucleotide variant Renal tubular dysgenesis [RCV001100120] Chr1:230710079 [GRCh38]
Chr1:230845825 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_000029.4(AGT):c.*288C>T single nucleotide variant Renal tubular dysgenesis [RCV001098248] Chr1:230702853 [GRCh38]
Chr1:230838599 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_000029.4(AGT):c.842A>G (p.Tyr281Cys) single nucleotide variant Renal tubular dysgenesis [RCV001098337]|not provided [RCV001572917] Chr1:230710009 [GRCh38]
Chr1:230845755 [GRCh37]
Chr1:1q42.2
likely benign|uncertain significance
NM_000029.4(AGT):c.1261G>A (p.Val421Met) single nucleotide variant Renal tubular dysgenesis [RCV001102004]|not provided [RCV002554985] Chr1:230704201 [GRCh38]
Chr1:230839947 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_000029.4(AGT):c.1174C>A (p.Leu392Met) single nucleotide variant AGT-related disorder [RCV003953473]|Renal tubular dysgenesis [RCV001102006]|not provided [RCV002554986] Chr1:230704288 [GRCh38]
Chr1:230840034 [GRCh37]
Chr1:1q42.2
benign|likely benign|uncertain significance
NM_000029.4(AGT):c.*347G>A single nucleotide variant Renal tubular dysgenesis [RCV001098247] Chr1:230702794 [GRCh38]
Chr1:230838540 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_000029.4(AGT):c.162G>A (p.Leu54=) single nucleotide variant Renal tubular dysgenesis [RCV001102119] Chr1:230710689 [GRCh38]
Chr1:230846435 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_000029.4(AGT):c.-25G>C single nucleotide variant Renal tubular dysgenesis [RCV001102124] Chr1:230714107 [GRCh38]
Chr1:230849853 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_000029.4(AGT):c.1270-1G>A single nucleotide variant Microcephaly [RCV001252821] Chr1:230703330 [GRCh38]
Chr1:230839076 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_001384479.1(AGT):c.76C>T (p.Arg26Trp) single nucleotide variant Anhydramnios [RCV001807665]|Essential hypertension, genetic [RCV002489840]|Essential hypertension, genetic [RCV003989714] Chr1:230710748 [GRCh38]
Chr1:230846494 [GRCh37]
Chr1:1q42.2
likely pathogenic|uncertain significance
NM_001384479.1(AGT):c.1263dup (p.Glu422Ter) duplication Large fontanelles [RCV001807656] Chr1:230703308..230703309 [GRCh38]
Chr1:230839054..230839055 [GRCh37]
Chr1:1q42.2
likely pathogenic
NC_000001.10:g.(?_130980840)_(248900000_?)dup duplication Gastrointestinal stromal tumor [RCV001300221]|Parathyroid carcinoma [RCV001341077] Chr1:130980840..248900000 [GRCh37]
Chr1:1q12-44
uncertain significance
NM_001384479.1(AGT):c.704T>G (p.Leu235Arg) single nucleotide variant not provided [RCV001355261] Chr1:230710120 [GRCh38]
Chr1:230845866 [GRCh37]
Chr1:1q42.2
likely benign|conflicting interpretations of pathogenicity|uncertain significance
NM_001384479.1(AGT):c.1097+120C>T single nucleotide variant not provided [RCV001694401] Chr1:230705813 [GRCh38]
Chr1:230841559 [GRCh37]
Chr1:1q42.2
benign
NM_001384479.1(AGT):c.1345C>T (p.Arg449Cys) single nucleotide variant not provided [RCV001457333] Chr1:230703227 [GRCh38]
Chr1:230838973 [GRCh37]
Chr1:1q42.2
likely benign|conflicting interpretations of pathogenicity
NM_001384479.1(AGT):c.1405G>A (p.Val469Met) single nucleotide variant not provided [RCV003107229] Chr1:230703167 [GRCh38]
Chr1:230838913 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_001384479.1(AGT):c.380C>T (p.Pro127Leu) single nucleotide variant Essential hypertension, genetic [RCV002488546]|not provided [RCV001767313] Chr1:230710444 [GRCh38]
Chr1:230846190 [GRCh37]
Chr1:1q42.2
uncertain significance
GRCh37/hg19 1q42.12-42.2(chr1:226131690-231908227) copy number loss not specified [RCV002052878] Chr1:226131690..231908227 [GRCh37]
Chr1:1q42.12-42.2
likely pathogenic
NM_001384479.1(AGT):c.65C>G (p.Ala22Gly) single nucleotide variant not provided [RCV001947642] Chr1:230710759 [GRCh38]
Chr1:230846505 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_001384479.1(AGT):c.1097G>T (p.Arg366Leu) single nucleotide variant not provided [RCV001967789] Chr1:230705933 [GRCh38]
Chr1:230841679 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_001384479.1(AGT):c.952G>C (p.Asp318His) single nucleotide variant Essential hypertension, genetic [RCV002507013]|not provided [RCV001927889] Chr1:230706078 [GRCh38]
Chr1:230841824 [GRCh37]
Chr1:1q42.2
uncertain significance
GRCh37/hg19 1q42.13-42.2(chr1:228214912-231483538) copy number loss not specified [RCV002052889] Chr1:228214912..231483538 [GRCh37]
Chr1:1q42.13-42.2
pathogenic
NC_000001.10:g.(?_229567246)_(232172577_?)dup duplication Actin accumulation myopathy [RCV003120751]|not provided [RCV001943051] Chr1:229567246..232172577 [GRCh37]
Chr1:1q42.13-42.2
uncertain significance|no classifications from unflagged records
NC_000001.10:g.(?_230838887)_(230846596_?)del deletion not provided [RCV001975206] Chr1:230838887..230846596 [GRCh37]
Chr1:1q42.2
pathogenic
NM_001384479.1(AGT):c.13G>A (p.Gly5Ser) single nucleotide variant Essential hypertension, genetic [RCV002484903]|not provided [RCV001974097] Chr1:230710811 [GRCh38]
Chr1:230846557 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_001384479.1(AGT):c.1315A>G (p.Lys439Glu) single nucleotide variant not provided [RCV001875690] Chr1:230703257 [GRCh38]
Chr1:230839003 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_001384479.1(AGT):c.286A>G (p.Met96Val) single nucleotide variant not provided [RCV002127639] Chr1:230710538 [GRCh38]
Chr1:230846284 [GRCh37]
Chr1:1q42.2
likely benign
NM_001384479.1(AGT):c.1180_1182dup (p.Ala394dup) duplication not provided [RCV002110308] Chr1:230704252..230704253 [GRCh38]
Chr1:230839998..230839999 [GRCh37]
Chr1:1q42.2
likely benign
NM_001384479.1(AGT):c.388G>C (p.Val130Leu) single nucleotide variant not provided [RCV002194678] Chr1:230710436 [GRCh38]
Chr1:230846182 [GRCh37]
Chr1:1q42.2
likely benign
NM_001384479.1(AGT):c.264C>T (p.Thr88=) single nucleotide variant Essential hypertension, genetic [RCV002479898]|not provided [RCV002097901] Chr1:230710560 [GRCh38]
Chr1:230846306 [GRCh37]
Chr1:1q42.2
likely benign
NM_001384479.1(AGT):c.830-20G>A single nucleotide variant Essential hypertension, genetic [RCV002496113]|not provided [RCV002181894] Chr1:230706220 [GRCh38]
Chr1:230841966 [GRCh37]
Chr1:1q42.2
likely benign
NC_000001.10:g.(?_230203028)_(231413288_?)del deletion Congenital disorder of glycosylation, type IIq [RCV003109448]|not provided [RCV003113491] Chr1:230203028..231413288 [GRCh37]
Chr1:1q42.13-42.2
pathogenic|no classifications from unflagged records
NM_001384479.1(AGT):c.684C>T (p.Arg228=) single nucleotide variant not provided [RCV003114731] Chr1:230710140 [GRCh38]
Chr1:230845886 [GRCh37]
Chr1:1q42.2
likely benign
NC_000001.10:g.(?_229567246)_(231413288_?)del deletion not provided [RCV003116710] Chr1:229567246..231413288 [GRCh37]
Chr1:1q42.13-42.2
pathogenic
GRCh37/hg19 1q31.3-44(chr1:197867914-249224684)x3 copy number gain See cases [RCV002287837] Chr1:197867914..249224684 [GRCh37]
Chr1:1q31.3-44
pathogenic
NM_001384479.1(AGT):c.382A>G (p.Thr128Ala) single nucleotide variant not provided [RCV003073758] Chr1:230710442 [GRCh38]
Chr1:230846188 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_001384479.1(AGT):c.370G>A (p.Val124Ile) single nucleotide variant Inborn genetic diseases [RCV004067233]|not provided [RCV002947799] Chr1:230710454 [GRCh38]
Chr1:230846200 [GRCh37]
Chr1:1q42.2
likely benign|uncertain significance
NM_001384479.1(AGT):c.221C>T (p.Ala74Val) single nucleotide variant not provided [RCV002947863] Chr1:230710603 [GRCh38]
Chr1:230846349 [GRCh37]
Chr1:1q42.2
likely benign
NM_001384479.1(AGT):c.-17G>C single nucleotide variant not provided [RCV002947343] Chr1:230710840 [GRCh38]
Chr1:230846586 [GRCh37]
Chr1:1q42.2
uncertain significance
GRCh37/hg19 1q42.13-43(chr1:227992928-236659905)x3 copy number gain not provided [RCV002475638] Chr1:227992928..236659905 [GRCh37]
Chr1:1q42.13-43
likely pathogenic
NM_001384479.1(AGT):c.332T>C (p.Met111Thr) single nucleotide variant Inborn genetic diseases [RCV002818343] Chr1:230710492 [GRCh38]
Chr1:230846238 [GRCh37]
Chr1:1q42.2
likely benign
NM_001384479.1(AGT):c.310T>C (p.Leu104=) single nucleotide variant AGT-related disorder [RCV003903779]|not provided [RCV002775928] Chr1:230710514 [GRCh38]
Chr1:230846260 [GRCh37]
Chr1:1q42.2
likely benign
NM_001384479.1(AGT):c.151G>A (p.Gly51Arg) single nucleotide variant Inborn genetic diseases [RCV002687648] Chr1:230710673 [GRCh38]
Chr1:230846419 [GRCh37]
Chr1:1q42.2
uncertain significance
GRCh37/hg19 1q41-44(chr1:223972939-249224684)x3 copy number gain not provided [RCV002475745] Chr1:223972939..249224684 [GRCh37]
Chr1:1q41-44
pathogenic
NM_001384479.1(AGT):c.-17G>A single nucleotide variant not provided [RCV002621905] Chr1:230710840 [GRCh38]
Chr1:230846586 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_001384479.1(AGT):c.1403G>A (p.Arg468His) single nucleotide variant not provided [RCV002923243] Chr1:230703169 [GRCh38]
Chr1:230838915 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_001384479.1(AGT):c.1097+8C>T single nucleotide variant not provided [RCV003077983] Chr1:230705925 [GRCh38]
Chr1:230841671 [GRCh37]
Chr1:1q42.2
likely benign
NM_001384479.1(AGT):c.103G>A (p.Val35Ile) single nucleotide variant not provided [RCV003081513] Chr1:230710721 [GRCh38]
Chr1:230846467 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_001384479.1(AGT):c.933G>A (p.Gln311=) single nucleotide variant not provided [RCV002866702] Chr1:230706097 [GRCh38]
Chr1:230841843 [GRCh37]
Chr1:1q42.2
likely benign
NM_001384479.1(AGT):c.603C>T (p.Gly201=) single nucleotide variant not provided [RCV002569660] Chr1:230710221 [GRCh38]
Chr1:230845967 [GRCh37]
Chr1:1q42.2
likely benign
NM_001384479.1(AGT):c.1332G>A (p.Glu444=) single nucleotide variant not provided [RCV003054494] Chr1:230703240 [GRCh38]
Chr1:230838986 [GRCh37]
Chr1:1q42.2
likely benign
NM_001384479.1(AGT):c.763G>A (p.Gly255Ser) single nucleotide variant not provided [RCV002948598] Chr1:230710061 [GRCh38]
Chr1:230845807 [GRCh37]
Chr1:1q42.2
likely benign
NM_001384479.1(AGT):c.1236G>C (p.Val412=) single nucleotide variant not provided [RCV002785439] Chr1:230704199 [GRCh38]
Chr1:230839945 [GRCh37]
Chr1:1q42.2
likely benign
NM_001384479.1(AGT):c.830-11C>G single nucleotide variant not provided [RCV002570305] Chr1:230706211 [GRCh38]
Chr1:230841957 [GRCh37]
Chr1:1q42.2
likely benign
NM_001384479.1(AGT):c.830-15C>T single nucleotide variant not provided [RCV002576198] Chr1:230706215 [GRCh38]
Chr1:230841961 [GRCh37]
Chr1:1q42.2
likely benign
NM_001384479.1(AGT):c.770C>T (p.Ser257Phe) single nucleotide variant Inborn genetic diseases [RCV002956564] Chr1:230710054 [GRCh38]
Chr1:230845800 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_001384479.1(AGT):c.185C>T (p.Pro62Leu) single nucleotide variant not provided [RCV003082479] Chr1:230710639 [GRCh38]
Chr1:230846385 [GRCh37]
Chr1:1q42.2
likely benign
NM_001384479.1(AGT):c.150C>T (p.Ala50=) single nucleotide variant not provided [RCV003081959] Chr1:230710674 [GRCh38]
Chr1:230846420 [GRCh37]
Chr1:1q42.2
likely benign
NM_001384479.1(AGT):c.1365G>A (p.Val455=) single nucleotide variant not provided [RCV002805619] Chr1:230703207 [GRCh38]
Chr1:230838953 [GRCh37]
Chr1:1q42.2
likely benign
NM_001384479.1(AGT):c.511G>A (p.Val171Ile) single nucleotide variant not provided [RCV003008096] Chr1:230710313 [GRCh38]
Chr1:230846059 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_001384479.1(AGT):c.1207C>A (p.Gln403Lys) single nucleotide variant not provided [RCV002595259] Chr1:230704228 [GRCh38]
Chr1:230839974 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_001384479.1(AGT):c.703C>T (p.Leu235=) single nucleotide variant not provided [RCV002595316] Chr1:230710121 [GRCh38]
Chr1:230845867 [GRCh37]
Chr1:1q42.2
likely benign
NM_001384479.1(AGT):c.1346G>A (p.Arg449His) single nucleotide variant Inborn genetic diseases [RCV002697367] Chr1:230703226 [GRCh38]
Chr1:230838972 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_001384479.1(AGT):c.914C>G (p.Ser305Cys) single nucleotide variant not provided [RCV002953935] Chr1:230706116 [GRCh38]
Chr1:230841862 [GRCh37]
Chr1:1q42.2
uncertain significance
GRCh37/hg19 1q42.11-43(chr1:224230307-243181599)x3 copy number gain not provided [RCV002509019] Chr1:224230307..243181599 [GRCh37]
Chr1:1q42.11-43
not provided
NM_001384479.1(AGT):c.1404C>T (p.Arg468=) single nucleotide variant not provided [RCV003090565] Chr1:230703168 [GRCh38]
Chr1:230838914 [GRCh37]
Chr1:1q42.2
likely benign
NM_001384479.1(AGT):c.894A>C (p.Ser298=) single nucleotide variant not provided [RCV002582017] Chr1:230706136 [GRCh38]
Chr1:230841882 [GRCh37]
Chr1:1q42.2
likely benign
NM_001384479.1(AGT):c.303C>T (p.Ala101=) single nucleotide variant not provided [RCV002582018] Chr1:230710521 [GRCh38]
Chr1:230846267 [GRCh37]
Chr1:1q42.2
likely benign
NM_001384479.1(AGT):c.803C>A (p.Ala268Asp) single nucleotide variant Inborn genetic diseases [RCV002934880] Chr1:230710021 [GRCh38]
Chr1:230845767 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_001384479.1(AGT):c.817G>A (p.Val273Ile) single nucleotide variant not provided [RCV002602413] Chr1:230710007 [GRCh38]
Chr1:230845753 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_001384479.1(AGT):c.246C>T (p.Val82=) single nucleotide variant not provided [RCV002895891] Chr1:230710578 [GRCh38]
Chr1:230846324 [GRCh37]
Chr1:1q42.2
benign
NM_001384479.1(AGT):c.782C>G (p.Ala261Gly) single nucleotide variant Inborn genetic diseases [RCV002748577] Chr1:230710042 [GRCh38]
Chr1:230845788 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_001384479.1(AGT):c.203C>G (p.Ser68Cys) single nucleotide variant not provided [RCV003048490] Chr1:230710621 [GRCh38]
Chr1:230846367 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_001384479.1(AGT):c.351C>T (p.Gly117=) single nucleotide variant AGT-related disorder [RCV003963399]|not provided [RCV002900184] Chr1:230710473 [GRCh38]
Chr1:230846219 [GRCh37]
Chr1:1q42.2
benign|likely benign
NM_001384479.1(AGT):c.594G>A (p.Thr198=) single nucleotide variant not provided [RCV002602578] Chr1:230710230 [GRCh38]
Chr1:230845976 [GRCh37]
Chr1:1q42.2
likely benign
NM_001384479.1(AGT):c.1243-12G>T single nucleotide variant not provided [RCV002587284] Chr1:230703341 [GRCh38]
Chr1:230839087 [GRCh37]
Chr1:1q42.2
likely benign
NM_001384479.1(AGT):c.494G>A (p.Arg165Gln) single nucleotide variant not provided [RCV002635076] Chr1:230710330 [GRCh38]
Chr1:230846076 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_001384479.1(AGT):c.983C>T (p.Thr328Ile) single nucleotide variant Inborn genetic diseases [RCV002723763] Chr1:230706047 [GRCh38]
Chr1:230841793 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_001384479.1(AGT):c.858C>T (p.Ala286=) single nucleotide variant not provided [RCV002607024] Chr1:230706172 [GRCh38]
Chr1:230841918 [GRCh37]
Chr1:1q42.2
likely benign
NM_001384479.1(AGT):c.1379C>A (p.Ala460Asp) single nucleotide variant Inborn genetic diseases [RCV003202837] Chr1:230703193 [GRCh38]
Chr1:230838939 [GRCh37]
Chr1:1q42.2
uncertain significance
GRCh38/hg38 1q42.13-44(chr1:230178121-243646135)x1 copy number loss Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2 [RCV003327728] Chr1:230178121..243646135 [GRCh38]
Chr1:1q42.13-44
pathogenic
NM_001384479.1(AGT):c.992C>G (p.Ala331Gly) single nucleotide variant Inborn genetic diseases [RCV003365036] Chr1:230706038 [GRCh38]
Chr1:230841784 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_001384479.1(AGT):c.1351T>A (p.Phe451Ile) single nucleotide variant not provided [RCV003489541] Chr1:230703221 [GRCh38]
Chr1:230838967 [GRCh37]
Chr1:1q42.2
uncertain significance
GRCh37/hg19 1q42.13-43(chr1:230231959-238032346)x1 copy number loss not provided [RCV003484077] Chr1:230231959..238032346 [GRCh37]
Chr1:1q42.13-43
pathogenic
GRCh37/hg19 1q42.13-44(chr1:229373250-249206595)x3 copy number gain not provided [RCV003484052] Chr1:229373250..249206595 [GRCh37]
Chr1:1q42.13-44
pathogenic
NM_001384479.1(AGT):c.323T>G (p.Ile108Arg) single nucleotide variant AGT-related disorder [RCV003402941] Chr1:230710501 [GRCh38]
Chr1:230846247 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_001384479.1(AGT):c.1017C>T (p.His339=) single nucleotide variant not provided [RCV003828846] Chr1:230706013 [GRCh38]
Chr1:230841759 [GRCh37]
Chr1:1q42.2
likely benign
NM_001384479.1(AGT):c.-24C>T single nucleotide variant not provided [RCV003829331] Chr1:230710847 [GRCh38]
Chr1:230846593 [GRCh37]
Chr1:1q42.2
likely benign
NM_001384479.1(AGT):c.1125G>A (p.Leu375=) single nucleotide variant not provided [RCV003716169] Chr1:230704310 [GRCh38]
Chr1:230840056 [GRCh37]
Chr1:1q42.2
likely benign
NM_001384479.1(AGT):c.749del (p.Thr250fs) deletion not provided [RCV003489540] Chr1:230710075 [GRCh38]
Chr1:230845821 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_001384479.1(AGT):c.669T>G (p.Pro223=) single nucleotide variant not provided [RCV003697882] Chr1:230710155 [GRCh38]
Chr1:230845901 [GRCh37]
Chr1:1q42.2
likely benign
NM_001384479.1(AGT):c.1179C>T (p.Pro393=) single nucleotide variant AGT-related disorder [RCV003921369]|not provided [RCV003837899] Chr1:230704256 [GRCh38]
Chr1:230840002 [GRCh37]
Chr1:1q42.2
likely benign
NM_001384479.1(AGT):c.810C>T (p.Asn270=) single nucleotide variant not provided [RCV003850906] Chr1:230710014 [GRCh38]
Chr1:230845760 [GRCh37]
Chr1:1q42.2
likely benign
NM_001384479.1(AGT):c.105C>A (p.Val35=) single nucleotide variant not provided [RCV003550410] Chr1:230710719 [GRCh38]
Chr1:230846465 [GRCh37]
Chr1:1q42.2
likely benign
NM_001384479.1(AGT):c.21C>T (p.Ser7=) single nucleotide variant not provided [RCV003557152] Chr1:230710803 [GRCh38]
Chr1:230846549 [GRCh37]
Chr1:1q42.2
likely benign
NM_001384479.1(AGT):c.255A>G (p.Lys85=) single nucleotide variant not provided [RCV003846451] Chr1:230710569 [GRCh38]
Chr1:230846315 [GRCh37]
Chr1:1q42.2
likely benign
NM_001384479.1(AGT):c.1194C>T (p.Thr398=) single nucleotide variant not provided [RCV003550566] Chr1:230704241 [GRCh38]
Chr1:230839987 [GRCh37]
Chr1:1q42.2
likely benign
NM_001384479.1(AGT):c.338G>A (p.Ser113Asn) single nucleotide variant Inborn genetic diseases [RCV004387050] Chr1:230710486 [GRCh38]
Chr1:230846232 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_001384479.1(AGT):c.625C>T (p.His209Tyr) single nucleotide variant Inborn genetic diseases [RCV004387057] Chr1:230710199 [GRCh38]
Chr1:230845945 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_001384479.1(AGT):c.287T>C (p.Met96Thr) single nucleotide variant Inborn genetic diseases [RCV004387045] Chr1:230710537 [GRCh38]
Chr1:230846283 [GRCh37]
Chr1:1q42.2
uncertain significance
NM_001384479.1(AGT):c.10G>A (p.Ala4Thr) single nucleotide variant Inborn genetic diseases [RCV004387051] Chr1:230710814 [GRCh38]
Chr1:230846560 [GRCh37]
Chr1:1q42.2
uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:263
Count of miRNA genes:246
Interacting mature miRNAs:255
Transcripts:ENST00000366667
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH91381  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371230,847,215 - 230,847,400UniSTSGRCh37
Build 361228,913,838 - 228,914,023RGDNCBI36
Celera1204,113,237 - 204,113,422RGD
Cytogenetic Map1q42.2UniSTS
HuRef1201,332,156 - 201,332,341UniSTS
GeneMap99-GB4 RH Map1737.43UniSTS
RH76317  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371230,847,347 - 230,847,557UniSTSGRCh37
Build 361228,913,970 - 228,914,180RGDNCBI36
Celera1204,113,369 - 204,113,579RGD
Cytogenetic Map1q42.2UniSTS
HuRef1201,332,288 - 201,332,498UniSTS
G44347  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371230,845,701 - 230,845,909UniSTSGRCh37
Build 361228,912,324 - 228,912,532RGDNCBI36
Celera1204,111,723 - 204,111,931RGD
Cytogenetic Map1q42.2UniSTS
HuRef1201,330,642 - 201,330,850UniSTS
RH121565  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371230,838,108 - 230,838,379UniSTSGRCh37
Build 361228,904,731 - 228,905,002RGDNCBI36
Celera1204,104,130 - 204,104,401RGD
Cytogenetic Map1q42.2UniSTS
HuRef1201,323,048 - 201,323,319UniSTS
TNG Radiation Hybrid Map1116278.0UniSTS
PMC310924P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371230,849,824 - 230,849,965UniSTSGRCh37
Build 361228,916,447 - 228,916,588RGDNCBI36
Celera1204,115,846 - 204,115,987RGD
Cytogenetic Map1q42.2UniSTS
HuRef1201,334,765 - 201,334,906UniSTS
G34823  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371230,838,382 - 230,838,484UniSTSGRCh37
Build 361228,905,005 - 228,905,107RGDNCBI36
Celera1204,104,404 - 204,104,506RGD
Cytogenetic Map1q42.2UniSTS
HuRef1201,323,322 - 201,323,424UniSTS
RH11650  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371230,838,346 - 230,838,567UniSTSGRCh37
Build 361228,904,969 - 228,905,190RGDNCBI36
Celera1204,104,368 - 204,104,589RGD
Cytogenetic Map1q42.2UniSTS
HuRef1201,323,286 - 201,323,507UniSTS
GeneMap99-GB4 RH Map1737.43UniSTS
NCBI RH Map12036.5UniSTS
STS-H64380  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371230,837,945 - 230,838,177UniSTSGRCh37
Build 361228,904,568 - 228,904,800RGDNCBI36
Celera1204,103,967 - 204,104,199RGD
Cytogenetic Map1q42.2UniSTS
HuRef1201,322,885 - 201,323,117UniSTS
GeneMap99-GB4 RH Map1736.11UniSTS
NCBI RH Map12035.0UniSTS
WI-8965  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371230,838,464 - 230,838,587UniSTSGRCh37
Build 361228,905,087 - 228,905,210RGDNCBI36
Celera1204,104,486 - 204,104,609RGD
Cytogenetic Map1q42.2UniSTS
HuRef1201,323,404 - 201,323,527UniSTS
Whitehead-YAC Contig Map1 UniSTS
RH11822  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371230,838,567 - 230,838,712UniSTSGRCh37
Build 361228,905,190 - 228,905,335RGDNCBI36
Celera1204,104,589 - 204,104,734RGD
Cytogenetic Map1q42.2UniSTS
HuRef1201,323,507 - 201,323,652UniSTS
GeneMap99-GB4 RH Map1737.43UniSTS
NCBI RH Map12032.6UniSTS
AGT_4206  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371230,838,215 - 230,839,023UniSTSGRCh37
Build 361228,904,838 - 228,905,646RGDNCBI36
Celera1204,104,237 - 204,105,045RGD
HuRef1201,323,155 - 201,323,963UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High 277 277 277 15 1 4
Medium 909 2216 1174 214 141 174 2308 1708 3498 257 501 817 41 555 2074
Low 1443 140 255 128 352 7 1722 451 158 122 832 652 121 649 672 3
Below cutoff 44 579 9 3 826 6 297 13 30 28 70 80 4 42

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_008836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_000029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001382817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001384479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB209769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB222866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF424741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH002594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK222798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK222815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK293507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK303755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK307978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK312291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL158214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL512328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AU128714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW128887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY436323 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC011519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF338744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT006851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC412932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF646866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF646867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF646868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF646869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF646870 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF646871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF646872 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU326304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU332836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ287930 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  K02215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF455160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M69110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S78529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S78530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  T97863 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  W01494 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X15324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000366667   ⟹   ENSP00000355627
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1230,702,523 - 230,714,122 (-)Ensembl
Ensembl Acc Id: ENST00000657140
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1230,692,533 - 230,696,888 (-)Ensembl
Ensembl Acc Id: ENST00000679684   ⟹   ENSP00000505981
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1230,703,767 - 230,714,566 (-)Ensembl
Ensembl Acc Id: ENST00000679738   ⟹   ENSP00000505063
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1230,692,511 - 230,714,645 (-)Ensembl
Ensembl Acc Id: ENST00000679802   ⟹   ENSP00000505184
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1230,692,511 - 230,714,566 (-)Ensembl
Ensembl Acc Id: ENST00000679854
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1230,692,511 - 230,714,566 (-)Ensembl
Ensembl Acc Id: ENST00000679957   ⟹   ENSP00000506646
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1230,703,141 - 230,714,566 (-)Ensembl
Ensembl Acc Id: ENST00000680041   ⟹   ENSP00000504866
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1230,702,155 - 230,714,145 (-)Ensembl
Ensembl Acc Id: ENST00000680783   ⟹   ENSP00000506329
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1230,690,776 - 230,714,566 (-)Ensembl
Ensembl Acc Id: ENST00000681269   ⟹   ENSP00000505985
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1230,702,523 - 230,745,576 (-)Ensembl
Ensembl Acc Id: ENST00000681347
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1230,692,511 - 230,714,566 (-)Ensembl
Ensembl Acc Id: ENST00000681514   ⟹   ENSP00000505963
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1230,702,155 - 230,714,122 (-)Ensembl
Ensembl Acc Id: ENST00000681772   ⟹   ENSP00000505829
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1230,692,511 - 230,714,566 (-)Ensembl
RefSeq Acc Id: NM_001382817   ⟹   NP_001369746
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381230,702,523 - 230,745,583 (-)NCBI
T2T-CHM13v2.01230,083,077 - 230,126,137 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001384479   ⟹   NP_001371408
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381230,702,523 - 230,714,122 (-)NCBI
T2T-CHM13v2.01230,083,077 - 230,094,676 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_000020 (Get FASTA)   NCBI Sequence Viewer  
  NP_001369746 (Get FASTA)   NCBI Sequence Viewer  
  NP_001371408 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA51679 (Get FASTA)   NCBI Sequence Viewer  
  AAA51731 (Get FASTA)   NCBI Sequence Viewer  
  AAA52282 (Get FASTA)   NCBI Sequence Viewer  
  AAD14287 (Get FASTA)   NCBI Sequence Viewer  
  AAD14288 (Get FASTA)   NCBI Sequence Viewer  
  AAH11519 (Get FASTA)   NCBI Sequence Viewer  
  AAP35497 (Get FASTA)   NCBI Sequence Viewer  
  AAR03501 (Get FASTA)   NCBI Sequence Viewer  
  ABS30408 (Get FASTA)   NCBI Sequence Viewer  
  ABS30409 (Get FASTA)   NCBI Sequence Viewer  
  ABS30410 (Get FASTA)   NCBI Sequence Viewer  
  ABS30411 (Get FASTA)   NCBI Sequence Viewer  
  ABS30412 (Get FASTA)   NCBI Sequence Viewer  
  ABS30413 (Get FASTA)   NCBI Sequence Viewer  
  ABS30414 (Get FASTA)   NCBI Sequence Viewer  
  ABY87525 (Get FASTA)   NCBI Sequence Viewer  
  ACA05910 (Get FASTA)   NCBI Sequence Viewer  
  BAD93006 (Get FASTA)   NCBI Sequence Viewer  
  BAD96518 (Get FASTA)   NCBI Sequence Viewer  
  BAD96535 (Get FASTA)   NCBI Sequence Viewer  
  BAG35218 (Get FASTA)   NCBI Sequence Viewer  
  BAG56991 (Get FASTA)   NCBI Sequence Viewer  
  BAG64725 (Get FASTA)   NCBI Sequence Viewer  
  BAX24569 (Get FASTA)   NCBI Sequence Viewer  
  CAA33385 (Get FASTA)   NCBI Sequence Viewer  
  EAW69918 (Get FASTA)   NCBI Sequence Viewer  
  EAW69919 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000355627
  ENSP00000355627.5
  ENSP00000504866
  ENSP00000504866.1
  ENSP00000505063
  ENSP00000505063.1
  ENSP00000505184.1
  ENSP00000505829.1
  ENSP00000505963
  ENSP00000505963.1
  ENSP00000505981.1
  ENSP00000505985
  ENSP00000505985.1
  ENSP00000506329.1
  ENSP00000506646.1
GenBank Protein P01019 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001369746   ⟸   NM_001382817
- Peptide Label: precursor
- UniProtKB: Q16359 (UniProtKB/Swiss-Prot),   Q16358 (UniProtKB/Swiss-Prot),   P01019 (UniProtKB/Swiss-Prot),   Q96F91 (UniProtKB/Swiss-Prot),   A0A7P0T8D1 (UniProtKB/TrEMBL),   A0A7P0TBH1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSP00000355627   ⟸   ENST00000366667
RefSeq Acc Id: NP_001371408   ⟸   NM_001384479
- Peptide Label: precursor
- UniProtKB: Q96F91 (UniProtKB/Swiss-Prot),   Q16359 (UniProtKB/Swiss-Prot),   Q16358 (UniProtKB/Swiss-Prot),   P01019 (UniProtKB/Swiss-Prot),   A0A7P0T8D1 (UniProtKB/TrEMBL),   A0A7P0TBH1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSP00000505981   ⟸   ENST00000679684
Ensembl Acc Id: ENSP00000505184   ⟸   ENST00000679802
Ensembl Acc Id: ENSP00000504866   ⟸   ENST00000680041
Ensembl Acc Id: ENSP00000505829   ⟸   ENST00000681772
Ensembl Acc Id: ENSP00000505063   ⟸   ENST00000679738
Ensembl Acc Id: ENSP00000505985   ⟸   ENST00000681269
Ensembl Acc Id: ENSP00000505963   ⟸   ENST00000681514
Ensembl Acc Id: ENSP00000506329   ⟸   ENST00000680783
Ensembl Acc Id: ENSP00000506646   ⟸   ENST00000679957
Protein Domains
SERPIN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure Video
AF-P01019-F1-model_v2 AlphaFold P01019 1-476 view protein structure  
AGT - Oxidized pdb 2x0b P01019 34-485 view protein structure view video
AGT - Reduced pdb 2x0b P01019 34-485 view protein structure view video
AGT - Renin pdb 2x0b P01019 34-485 view protein structure view video

Promoters
RGD ID:6850070
Promoter ID:EP36006
Type:multiple initiation site
Name:HS_AGT_3
Description:Angiotensinogen.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 207; Mammalian angiotensin.
Alternative Promoters:alternative promoter #3 of 3; 5' exon 1; site 3; major promoter.; see alsoEP72001  EP72002  
Tissues & Cell Lines:liver
Experiment Methods:Sequencing of a full-length cDNA; NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 361228,916,490 - 228,916,550EPD
RGD ID:6850068
Promoter ID:EP72002
Type:initiation region
Name:HS_AGT_2
Description:Angiotensinogen.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:alternative promoter #2 of 3; 5' exon 1; site 2.; see alsoEP72001  EP36006  
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 361228,916,587 - 228,916,647EPD
RGD ID:6850066
Promoter ID:EP72001
Type:initiation region
Name:HS_AGT_1
Description:Angiotensinogen.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:alternative promoter #1 of 3; 5' exon 1; site 1.; see alsoEP72002  EP36006  
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 361228,916,676 - 228,916,736EPD
RGD ID:6859242
Promoter ID:EPDNEW_H2785
Type:multiple initiation site
Name:AGT_1
Description:angiotensinogen
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381230,714,121 - 230,714,181EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:333 AgrOrtholog
COSMIC AGT COSMIC
Ensembl Genes ENSG00000135744 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000366667 ENTREZGENE
  ENST00000366667.6 UniProtKB/Swiss-Prot
  ENST00000679684.1 UniProtKB/TrEMBL
  ENST00000679738 UniProtKB/TrEMBL
  ENST00000679738.1 UniProtKB/Swiss-Prot
  ENST00000679802.1 UniProtKB/TrEMBL
  ENST00000679957.1 UniProtKB/TrEMBL
  ENST00000680041 UniProtKB/TrEMBL
  ENST00000680041.1 UniProtKB/Swiss-Prot
  ENST00000680783.1 UniProtKB/TrEMBL
  ENST00000681269 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000681269.1 UniProtKB/Swiss-Prot
  ENST00000681514 UniProtKB/TrEMBL
  ENST00000681514.1 UniProtKB/Swiss-Prot
  ENST00000681772.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.39.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.497.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000135744 GTEx
HGNC ID HGNC:333 ENTREZGENE
Human Proteome Map AGT Human Proteome Map
InterPro Angiotensinogen UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Angiotensinogen_serpin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_sf_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_sf_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 183 ENTREZGENE
PANTHER ANGIOTENSINOGEN UniProtKB/Swiss-Prot
  ANGIOTENSINOGEN UniProtKB/TrEMBL
  ANGIOTENSINOGEN UniProtKB/TrEMBL
  PTHR11461 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Serpin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB AGT RGD, PharmGKB
PRINTS ANGIOTENSNGN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SERPIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SERPIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56574 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A7P0T8D1 ENTREZGENE, UniProtKB/TrEMBL
  A0A7P0T9S6_HUMAN UniProtKB/TrEMBL
  A0A7P0TA52_HUMAN UniProtKB/TrEMBL
  A0A7P0TAP4_HUMAN UniProtKB/TrEMBL
  A0A7P0TBH1 ENTREZGENE, UniProtKB/TrEMBL
  A0A7P0Z441_HUMAN UniProtKB/TrEMBL
  A7L3A1_HUMAN UniProtKB/TrEMBL
  A7L3A2_HUMAN UniProtKB/TrEMBL
  A7L3A3_HUMAN UniProtKB/TrEMBL
  A7L3A4_HUMAN UniProtKB/TrEMBL
  A7L3A5_HUMAN UniProtKB/TrEMBL
  ANGT_HUMAN UniProtKB/Swiss-Prot
  B0ZBE2_HUMAN UniProtKB/TrEMBL
  B2R5S1_HUMAN UniProtKB/TrEMBL
  P01019 ENTREZGENE
  Q16358 ENTREZGENE
  Q16359 ENTREZGENE
  Q53YY1_HUMAN UniProtKB/TrEMBL
  Q96F91 ENTREZGENE
UniProt Secondary A0A024R3V3 UniProtKB/TrEMBL
  Q16358 UniProtKB/Swiss-Prot
  Q16359 UniProtKB/Swiss-Prot
  Q96F91 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-19 AGT  angiotensinogen  AGT  angiotensinogen (serpin peptidase inhibitor, clade A, member 8)  Symbol and/or name change 5135510 APPROVED