AGT (angiotensinogen) - Rat Genome Database

Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: AGT (angiotensinogen) Homo sapiens
Symbol: AGT
Name: angiotensinogen
RGD ID: 731070
HGNC Page HGNC:333
Description: Enables angiotensin receptor binding activity; hormone activity; and sodium channel regulator activity. Involved in several processes, including positive regulation of branching involved in ureteric bud morphogenesis; positive regulation of nitrogen compound metabolic process; and regulation of signal transduction. Located in blood microparticle; collagen-containing extracellular matrix; and extracellular exosome. Is active in extracellular space. Implicated in several diseases, including Fabry disease; Henoch-Schoenlein purpura; artery disease (multiple); heart conduction disease (multiple); and hydronephrosis. Biomarker of several diseases, including alcoholic hepatitis; chronic myeloid leukemia; intermediate coronary syndrome; systemic scleroderma (multiple); and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: alpha-1 antiproteinase, antitrypsin; angiotensin I; angiotensin II; angiotensinogen (serine (or cysteine) proteinase inhibitor, clade a (alpha-1 antiproteinase, antitrypsin), member 8); angiotensinogen (serpin peptidase inhibitor, clade A, member 8); ANHU; fetal-liver predominant transporter 1; FLJ92595; FLJ97926; hFLT1; pre-angiotensinogen; serine (or cysteine) proteinase inhibitor; serpin A8; serpin peptidase inhibitor, clade A, member 8; SERPINA8
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is relevant for disease process.
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381230,702,523 - 230,745,583 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1230,690,776 - 230,745,576 (-)EnsemblGRCh38hg38GRCh38
GRCh371230,838,269 - 230,881,329 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361228,904,892 - 228,916,564 (-)NCBINCBI36Build 36hg18NCBI36
Build 341227,145,019 - 227,156,602NCBI
Celera1204,104,291 - 204,116,358 (-)NCBICelera
Cytogenetic Map1q42.2NCBI
HuRef1201,323,209 - 201,335,277 (-)NCBIHuRef
CHM1_11232,111,282 - 232,123,349 (-)NCBICHM1_1
T2T-CHM13v2.01230,083,077 - 230,126,137 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (EXP)
Actin-Accumulation Myopathy  (IAGP)
Albuminuria  (EXP,IEA)
alcoholic cardiomyopathy  (EXP)
alcoholic hepatitis  (IEP)
Alkalosis  (EXP)
allergic disease  (IAGP)
Alzheimer's disease  (IEP)
Anaphylaxis  (IEP)
anemia  (EXP)
anti-basement membrane glomerulonephritis  (ISO)
anuria  (EXP)
aortic aneurysm  (EXP)
Aortic Calcification  (ISO)
Aortic Coarctation  (IAGP)
atherosclerosis  (EXP,ISO)
atrial fibrillation  (IAGP)
bipolar disorder  (IEA)
Bradycardia  (EXP)
breast cancer  (IAGP,IEP)
Cardiac Arrhythmias  (EXP)
Cardiomegaly  (EXP,ISO)
cardiomyopathy  (EXP)
Cardiotoxicity  (EXP)
Cardiovascular Abnormalities  (EXP)
cardiovascular system disease  (EXP,IAGP,IEA)
carotid artery disease  (EXP,IAGP)
Catalepsy  (EXP)
cerebrovascular disease  (IAGP)
Chemical and Drug Induced Liver Injury  (EXP)
cholestasis  (EXP)
Chronic Intermittent Hypoxia  (ISO)
chronic myeloid leukemia  (IEP)
cleidocranial dysplasia  (IAGP)
cognitive disorder  (EXP)
congenital disorder of glycosylation type IIq  (IAGP)
congestive heart failure  (EXP,IAGP,IEP,ISO)
corneal neovascularization  (ISO)
coronary artery disease  (IEA)
Crohn's disease  (IAGP)
Diabetic Cardiomyopathies  (EXP)
Diabetic Nephropathies  (EXP,IAGP,IEA)
diabetic retinopathy  (EXP,IAGP,ISO)
Diaphragmatic Hernia  (EXP)
diffuse scleroderma  (IEP)
dilated cardiomyopathy  (IAGP,ISO)
Dissecting Aneurysm  (EXP)
Drug Overdose  (EXP)
end stage renal disease  (IEA)
endomyocardial fibrosis  (EXP)
essential hypertension  (EXP,IAGP)
Experimental Diabetes Mellitus  (EXP)
Experimental Liver Cirrhosis  (EXP)
Experimental Mammary Neoplasms  (IDA)
Fabry disease  (IAGP)
Fetal Growth Retardation  (EXP,IMP,ISO)
Fibrosis  (EXP,ISO)
focal segmental glomerulosclerosis  (EXP,ISO)
gastric ulcer  (ISO)
gastrointestinal stromal tumor  (IAGP)
genetic disease  (IAGP)
glomerulonephritis  (EXP,ISO)
glucose intolerance  (EXP)
heart disease  (EXP)
Hemorrhage  (IAGP)
Henoch-Schoenlein purpura  (IAGP)
hydronephrosis  (IMP,ISO)
Hyperalgesia  (EXP)
Hyperemia  (EXP)
hyperhomocysteinemia  (EXP)
hyperinsulinism  (IAGP)
hypertension  (EXP,IAGP,IEA,ISO)
Hypertensive Nephropathy  (ISO)
hypertrophic cardiomyopathy  (IAGP)
Hypertrophy  (EXP)
hypokalemia  (EXP)
Hypotension  (EXP,ISO)
IgA glomerulonephritis  (EXP,IAGP)
impotence  (ISO)
Inflammation  (EXP)
inflammatory bowel disease  (IAGP)
intermediate coronary syndrome  (IEP)
Intestinal Reperfusion Injury  (ISO)
kidney disease  (EXP)
kidney failure  (EXP)
Left Ventricular Hypertrophy  (EXP)
liver cirrhosis  (EXP,ISO)
malignant hypertension  (EXP)
meconium aspiration syndrome  (ISO)
Metabolic Syndrome  (ISO)
microcephaly  (IAGP)
middle cerebral artery infarction  (ISO)
mitral valve prolapse  (IAGP,IEA)
multiple sclerosis  (IEP)
myocardial infarction  (EXP,IAGP,IEA,ISO)
Myocardial Ischemia  (EXP)
Myocardial Reperfusion Injury  (EXP)
Necrosis  (EXP)
Neointima  (EXP)
nephrosis  (EXP)
Neurobehavioral Manifestations  (EXP)
obesity  (IAGP)
oligohydramnios  (IAGP)
otosclerosis  (IAGP)
parathyroid carcinoma  (IAGP)
Peptic Ulcer Hemorrhage  (EXP)
pneumonia  (EXP)
polycystic kidney disease  (ISO)
pre-eclampsia  (EXP,IAGP,IMP)
prediabetes syndrome  (ISO)
Pregnancy-Induced Hypertension  (ISO)
Prenatal Exposure Delayed Effects  (ISO)
primary biliary cholangitis  (ISO)
proteinuria  (EXP)
pulmonary edema  (IAGP)
pulmonary fibrosis  (EXP,ISO)
pulmonary hypertension  (ISO)
Puromycin Aminonucleoside Nephrosis  (ISO)
renal hypertension  (EXP)
Renal Tubular Dysgenesis  (EXP,IAGP)
Reperfusion Injury  (EXP)
retinal vasculitis  (ISO)
retinopathy of prematurity  (EXP)
sciatic neuropathy  (ISO)
sick sinus syndrome  (IAGP)
skin melanoma  (IEP)
Stroke  (IAGP,IEA)
Sudden Death  (EXP)
systemic scleroderma  (IEP)
temporal lobe epilepsy  (ISO)
thrombosis  (EXP)
transient cerebral ischemia  (ISO)
type 2 diabetes mellitus  (IAGP,IEP)
ureteral obstruction  (EXP)
vascular disease  (EXP)
Vascular Malformations  (IEP)
Vascular Remodeling  (EXP)
Ventricular Dysfunction, Left  (EXP)
Ventricular Remodeling  (EXP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(+)-taxifolin  (ISO)
(1->4)-beta-D-glucan  (ISO)
(R)-lipoic acid  (ISO)
(R)-noradrenaline  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-amphetamine  (ISO)
1,2-dichloroethane  (ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (ISO)
11-deoxycorticosterone  (ISO)
11-Hydroxyandrostenedione  (EXP)
14,15-EET  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2,6-dinitrotoluene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
3',5'-cyclic GMP  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (EXP)
3,7-dihydropurine-6-thione  (ISO)
3-[3-acetyl-4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl]-1,1-diethylurea  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-Hydroperoxy-2-nonenal  (EXP)
4-hydroperoxycyclophosphamide  (EXP)
4-hydroxy-TEMPO  (ISO)
4-hydroxynon-2-enal  (EXP)
4-phenylbutyric acid  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-oxoprostaglandin F1alpha  (ISO)
6-propyl-2-thiouracil  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP,ISO)
8-Br-cAMP  (EXP)
8-hydroxy-2'-deoxyguanosine  (EXP)
Ac-Ser-Asp-Lys-Pro-OH  (EXP,ISO)
acadesine  (ISO)
acetamide  (ISO)
acetylcholine  (ISO)
acetylsalicylic acid  (EXP)
actinomycin D  (EXP,ISO)
adefovir  (ISO)
Adenosine, cyclic 3',5'-[hydrogen [p(s)]-phosphorothioate]  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (EXP,ISO)
aliskiren  (ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (ISO)
alpha-cyano-4-hydroxycinnamic acid  (ISO)
amidotrizoic acid  (ISO)
amiloride  (EXP,ISO)
amiodarone  (EXP,ISO)
amitrole  (ISO)
amlodipine  (EXP)
ammonia  (ISO)
ammonium chloride  (ISO)
angiotensin II  (EXP,ISO)
apocynin  (EXP,ISO)
arachidonic acid  (ISO)
aristolochic acid A  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
aspartame  (EXP)
astressin  (ISO)
atenolol  (EXP)
atorvastatin calcium  (ISO)
azoxystrobin  (ISO)
bafilomycin A1  (ISO)
benazepril  (EXP,ISO)
benidipine  (EXP)
benzbromarone  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-D-glucosamine  (ISO)
beta-endorphin  (ISO)
biopterin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol F  (ISO)
boric acid  (ISO)
BQ 123  (ISO)
brefeldin A  (ISO)
brimonidine tartrate  (ISO)
Brodifacoum  (ISO)
bucladesine  (EXP)
butan-1-ol  (EXP,ISO)
butanal  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calciol  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
Calphostin C  (ISO)
candesartan  (EXP,ISO)
Candesartan cilexetil  (EXP,ISO)
captopril  (EXP,ISO)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
carmustine  (EXP)
carvedilol  (EXP,ISO)
CGP-42112A  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
chromium atom  (ISO)
chymostatin  (EXP,ISO)
ciglitazone  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
clofibric acid  (ISO)
clozapine  (EXP)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP)
cordycepin  (EXP)
corticosterone  (EXP)
cortisol  (EXP)
crotonaldehyde  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cyclosporin A  (EXP,ISO)
cypermethrin  (ISO)
D-glucose  (EXP,ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
dibenziodolium  (ISO)
diethyl malate  (ISO)
diminazene diaceturate  (EXP,ISO)
dioxygen  (ISO)
diquat  (ISO)
disodium cromoglycate  (ISO)
diuron  (ISO)
dopamine  (EXP)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
doxycycline  (ISO)
EC (peptidyl-dipeptidase A) inhibitor  (EXP,ISO)
efonidipine hydrochloride  (EXP)
elcometrine  (EXP)
emodin  (ISO)
enalapril  (EXP,ISO)
enalaprilat dihydrate  (EXP,ISO)
endosulfan  (ISO)
eplerenone  (ISO)
ergosta-4,6,8(14),22-tetraen-3-one  (EXP,ISO)
ethanol  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
famotidine  (ISO)
fenofibrate  (ISO)
flavonoids  (EXP)
flutamide  (ISO)
folic acid  (ISO)
fosinopril  (ISO)
fructose  (ISO)
fulvestrant  (EXP,ISO)
fumonisin B1  (EXP,ISO)
furan  (ISO)
furosemide  (EXP)
genistein  (EXP)
gentamycin  (ISO)
Ginkgoic acid  (ISO)
glucose  (EXP,ISO)
glutathione  (EXP,ISO)
glutathione disulfide  (ISO)
glycerol  (ISO)
glycochenodeoxycholic acid  (ISO)
glyphosate  (ISO)
goralatide  (EXP,ISO)
Harpagide  (ISO)
heparin  (ISO)
hydralazine  (ISO)
hydrazines  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (EXP)
ibuprofen  (ISO)
icatibant  (ISO)
ICI 118551  (ISO)
Ile(5)-angiotensin II  (EXP,ISO)
imidacloprid  (ISO)
imidaprilat  (ISO)
imperatorin  (ISO)
indometacin  (EXP,ISO)
iohexol  (ISO)
irbesartan  (EXP,ISO)
irinotecan  (EXP)
isoprenaline  (EXP,ISO)
isorhamnetin  (ISO)
Isorhapontigenin  (ISO)
ketamine  (EXP,ISO)
ketoconazole  (ISO)
L-ascorbic acid  (EXP,ISO)
L-erythro-biopterin  (ISO)
L-ethionine  (ISO)
labetalol  (EXP)
lactacystin  (ISO)
lead(0)  (EXP,ISO)
levonorgestrel  (EXP)
linoleic acid hydroperoxide  (EXP)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lipoxin A4  (ISO)
lisinopril dihydrate  (EXP,ISO)
losartan  (EXP,ISO)
LY294002  (ISO)
Magnolol  (ISO)
malonaldehyde  (EXP,ISO)
mangiferin  (ISO)
medroxyprogesterone acetate  (EXP)
melatonin  (ISO)
mercaptopurine  (ISO)
mercury dichloride  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
methimazole  (ISO)
methotrexate  (ISO)
methylglyoxal  (ISO)
mevalonic acid  (ISO)
Mibefradil  (EXP)
microcystin RR  (ISO)
midostaurin  (ISO)
miquelianin  (EXP)
mithramycin  (ISO)
MK-2206  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (ISO)
montelukast  (EXP)
mycophenolic acid  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-desethylamiodarone  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methylnicotinate  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
naloxone  (ISO)
naringin  (EXP)
nebivolol  (ISO)
Neferine  (EXP)
nerolidol  (ISO)
nickel atom  (EXP)
nicorandil  (ISO)
nicotinic acid  (EXP,ISO)
nimesulide  (ISO)
nitric oxide  (EXP,ISO)
nitrites  (ISO)
nitrofen  (ISO)
nitrofurantoin  (ISO)
nitroprusside  (ISO)
NS-398  (ISO)
O-methyleugenol  (EXP)
ochratoxin A  (ISO)
okadaic acid  (ISO)
olmesartan  (EXP,ISO)
oltipraz  (ISO)
omeprazole  (ISO)
ouabain  (ISO)
ozone  (ISO)
Pachymic acid  (EXP,ISO)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
parathion  (ISO)
PD 168393  (ISO)
PD123319  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
perindopril  (EXP,ISO)
peroxynitrous acid  (ISO)
phenylarsine oxide  (ISO)
phenylephrine  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidic acid  (ISO)
phosphoramidon  (ISO)
pifithrin-?  (ISO)
pindolol  (EXP)
pioglitazone  (ISO)
pirinixic acid  (ISO)
potassium atom  (EXP)
potassium dichromate  (ISO)
pravastatin  (ISO)
pregabalin  (ISO)
probenecid  (ISO)
progesterone  (EXP,ISO)
propanal  (EXP)
propranolol  (EXP,ISO)
prostaglandin E1  (EXP)
prostaglandin E2  (ISO)
prostaglandin I2  (ISO)
prostaglandins E  (ISO)
purine-6-thiol  (ISO)
purines  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP,ISO)
quinacrine  (ISO)
quinapril hydrochloride  (ISO)
raloxifene  (EXP)
reactive oxygen species  (EXP,ISO)
reboxetine  (EXP)
resveratrol  (EXP,ISO)
rotenone  (EXP,ISO)
rottlerin  (ISO)
rutin  (ISO)
salubrinal  (ISO)
saralasin  (ISO)
SB 203580  (ISO)
scopolamine  (EXP)
sevoflurane  (ISO)
sildenafil citrate  (EXP,ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium atom  (EXP,ISO)
sodium chloride  (EXP,ISO)
sodium fluoride  (ISO)
Soman  (ISO)
spironolactone  (EXP,ISO)
streptozocin  (ISO)
succimer  (EXP)
sucrose  (ISO)
sulfadimethoxine  (ISO)
sulforaphane  (ISO)
sunitinib  (EXP)
superoxide  (EXP,ISO)
tamibarotene  (ISO)
tamoxifen  (EXP)
taurine  (ISO)
taurolithocholic acid sulfate  (ISO)
tauroursodeoxycholic acid  (ISO)
telmisartan  (ISO)
temozolomide  (EXP)
testosterone  (ISO)
Testosterone propionate  (ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
Theaflavin 3,3'-digallate  (ISO)
thiabendazole  (ISO)
thioacetamide  (ISO)
thiopental  (EXP)
Thiorphan  (EXP,ISO)
Tiron  (EXP,ISO)
titanium dioxide  (EXP,ISO)
torasemide  (ISO)
trandolapril  (ISO)
trans-piceid  (ISO)
tributylstannane  (ISO)
trichloroethene  (ISO)
triclosan  (EXP)
triticonazole  (ISO)
troglitazone  (EXP)
tyrphostin AG 1478  (ISO)
U-73122  (ISO)
valproic acid  (EXP,ISO)
valsartan  (EXP,ISO)
Vinpocetine  (ISO)
vismodegib  (EXP)
wortmannin  (ISO)
xanthone  (ISO)
xestospongin C  (ISO)
zaragozic acid A  (ISO)
zearalenone  (EXP)
zinc atom  (EXP,ISO)
zinc protoporphyrin  (EXP)