AGT (angiotensinogen) - Rat Genome Database

Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: AGT (angiotensinogen) Homo sapiens
Symbol: AGT
Name: angiotensinogen
RGD ID: 731070
Description: Enables angiotensin receptor binding activity; receptor ligand activity; and sodium channel regulator activity. Involved in several processes, including positive regulation of branching involved in ureteric bud morphogenesis; positive regulation of cellular metabolic process; and regulation of signal transduction. Located in extracellular space. Part of collagen-containing extracellular matrix. Implicated in several diseases, including Fabry disease; Henoch-Schoenlein purpura; artery disease (multiple); heart conduction disease (multiple); and hydronephrosis. Biomarker of several diseases, including alcoholic hepatitis; chronic myeloid leukemia; intermediate coronary syndrome; neurodegenerative disease (multiple); and systemic scleroderma (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: alpha-1 antiproteinase, antitrypsin; angiotensin I; angiotensin II; angiotensinogen (serine (or cysteine) proteinase inhibitor, clade a (alpha-1 antiproteinase, antitrypsin), member 8); angiotensinogen (serpin peptidase inhibitor, clade A, member 8); ANHU; fetal-liver predominant transporter 1; FLJ92595; FLJ97926; hFLT1; pre-angiotensinogen; serine (or cysteine) proteinase inhibitor; serpin A8; serpin peptidase inhibitor, clade A, member 8; SERPINA8
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is relevant for disease process.
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1230,690,776 - 230,745,576 (-)EnsemblGRCh38hg38GRCh38
GRCh381230,702,523 - 230,745,583 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371230,838,269 - 230,881,329 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361228,904,892 - 228,916,564 (-)NCBINCBI36hg18NCBI36
Build 341227,145,019 - 227,156,602NCBI
Celera1204,104,291 - 204,116,358 (-)NCBI
Cytogenetic Map1q42.2NCBI
HuRef1201,323,209 - 201,335,277 (-)NCBIHuRef
CHM1_11232,111,282 - 232,123,349 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (EXP)
Albuminuria  (EXP,IEA)
alcoholic cardiomyopathy  (EXP)
alcoholic hepatitis  (IEP)
Alkalosis  (EXP)
Allanson Pantzar McLeod Syndrome  (EXP)
allergic disease  (IAGP)
Alzheimer's disease  (IEP)
Anaphylaxis  (IEP)
anemia  (EXP)
anti-basement membrane glomerulonephritis  (ISO)
anuria  (EXP)
aortic aneurysm  (EXP)
Aortic Calcification  (ISO)
Aortic Coarctation  (IAGP)
atherosclerosis  (EXP,ISO)
atrial fibrillation  (IAGP)
bipolar disorder  (IEA)
Bradycardia  (EXP)
breast cancer  (IAGP,IEP)
Cardiac Arrhythmias  (EXP)
Cardiomegaly  (EXP,ISO)
cardiomyopathy  (EXP)
Cardiotoxicity  (EXP)
Cardiovascular Abnormalities  (EXP)
cardiovascular system disease  (EXP,IAGP,IEA)
carotid artery disease  (EXP,IAGP)
Catalepsy  (EXP)
cerebrovascular disease  (IAGP)
Chemical and Drug Induced Liver Injury  (EXP)
cholestasis  (EXP)
Chronic Intermittent Hypoxia  (ISO)
chronic myeloid leukemia  (IEP)
cognitive disorder  (EXP)
congestive heart failure  (EXP,IAGP,IEP,ISO)
corneal neovascularization  (ISO)
coronary artery disease  (IEA)
Crohn's disease  (IAGP)
Diabetic Cardiomyopathies  (EXP)
Diabetic Nephropathies  (EXP,IAGP,IEA)
diabetic retinopathy  (EXP,IAGP,ISO)
Diaphragmatic Hernia  (EXP)
diffuse scleroderma  (IEP)
dilated cardiomyopathy  (IAGP,ISO)
Dissecting Aneurysm  (EXP)
Drug Overdose  (EXP)
end stage renal disease  (IEA)
endomyocardial fibrosis  (EXP)
essential hypertension  (IAGP)
Experimental Diabetes Mellitus  (EXP)
Experimental Liver Cirrhosis  (EXP)
Fabry disease  (IAGP)
Fetal Growth Retardation  (EXP,IMP,ISO)
Fibrosis  (EXP,ISO)
focal segmental glomerulosclerosis  (EXP,ISO)
gastric ulcer  (ISO)
gastrointestinal stromal tumor  (IAGP)
glomerulonephritis  (EXP,ISO)
glucose intolerance  (EXP)
heart disease  (EXP)
Hemorrhage  (IAGP)
Henoch-Schoenlein purpura  (IAGP)
hydronephrosis  (IMP,ISO)
Hyperalgesia  (EXP)
Hyperemia  (EXP)
hyperhomocysteinemia  (EXP)
hyperinsulinism  (IAGP)
hypertension  (EXP,IAGP,IEA,ISO)
Hypertensive Nephropathy  (ISO)
hypertrophic cardiomyopathy  (IAGP)
Hypertrophy  (EXP)
hypokalemia  (EXP)
Hypotension  (EXP,ISO)
IgA glomerulonephritis  (EXP,IAGP)
impotence  (ISO)
Inflammation  (EXP)
inflammatory bowel disease  (IAGP)
intermediate coronary syndrome  (IEP)
Intestinal Reperfusion Injury  (ISO)
kidney disease  (EXP,IAGP)
kidney failure  (EXP)
Left Ventricular Hypertrophy  (EXP)
liver cirrhosis  (EXP,ISO)
malignant hypertension  (EXP)
Mammary Neoplasms, Experimental  (IDA)
meconium aspiration syndrome  (ISO)
Metabolic Syndrome  (ISO)
microcephaly  (IAGP)
middle cerebral artery infarction  (ISO)
mitral valve prolapse  (IAGP,IEA)
multiple sclerosis  (IEP)
myocardial infarction  (EXP,IAGP,IEA,ISO)
Myocardial Ischemia  (EXP)
Myocardial Reperfusion Injury  (EXP)
Necrosis  (EXP)
Neointima  (EXP)
nephrosis  (EXP)
Neurobehavioral Manifestations  (EXP)
obesity  (IAGP)
otosclerosis  (IAGP)
parathyroid carcinoma  (IAGP)
Peptic Ulcer Hemorrhage  (EXP)
pneumonia  (EXP)
polycystic kidney disease  (ISO)
pre-eclampsia  (EXP,IAGP,IMP)
prediabetes syndrome  (ISO)
Pregnancy-Induced Hypertension  (ISO)
primary biliary cholangitis  (ISO)
proteinuria  (EXP)
pulmonary edema  (IAGP)
pulmonary fibrosis  (EXP,ISO)
pulmonary hypertension  (ISO)
Puromycin Aminonucleoside Nephrosis  (ISO)
renal hypertension  (EXP)
Renal Tubular Dysgenesis  (IAGP)
Reperfusion Injury  (EXP)
retinal vasculitis  (ISO)
retinopathy of prematurity  (EXP)
sciatic neuropathy  (ISO)
sick sinus syndrome  (IAGP)
skin melanoma  (IEP)
Stroke  (IAGP,IEA)
Sudden Death  (EXP)
systemic scleroderma  (IEP)
temporal lobe epilepsy  (ISO)
thrombosis  (EXP)
transient cerebral ischemia  (ISO)
type 2 diabetes mellitus  (IAGP,IEP)
ureteral obstruction  (EXP)
vascular disease  (EXP)
Vascular Remodeling  (EXP)
Ventricular Dysfunction, Left  (EXP)
Ventricular Remodeling  (EXP)
visual epilepsy  (EXP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(+)-taxifolin  (ISO)
(R)-lipoic acid  (ISO)
(R)-mevalonic acid  (ISO)
(R)-noradrenaline  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-amphetamine  (ISO)
1,2-dichloroethane  (ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (ISO)
11-deoxycorticosterone  (ISO)
11-Hydroxyandrostenedione  (EXP)
14,15-EET  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2,6-dinitrotoluene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
3',5'-cyclic GMP  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (EXP)
3,7-dihydropurine-6-thione  (ISO)
3-[3-acetyl-4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl]-1,1-diethylurea  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-Hydroperoxy-2-nonenal  (EXP)
4-hydroperoxycyclophosphamide  (EXP)
4-Hydroxy-TEMPO  (ISO)
4-hydroxynon-2-enal  (EXP)
4-phenylbutyric acid  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-oxoprostaglandin F1alpha  (ISO)
6-propyl-2-thiouracil  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP,ISO)
8-Br-cAMP  (EXP)
8-hydroxy-2'-deoxyguanosine  (EXP)
Ac-Ser-Asp-Lys-Pro-OH  (EXP,ISO)
acadesine  (ISO)
acetamide  (ISO)
acetylcholine  (ISO)
acetylsalicylic acid  (EXP)
actinomycin D  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (EXP,ISO)
aliskiren  (ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (ISO)
alpha-cyano-4-hydroxycinnamic acid  (ISO)
amidotrizoic acid  (ISO)
amiloride  (EXP,ISO)
amiodarone  (EXP,ISO)
amitrole  (ISO)
amlodipine  (EXP)
ammonia  (ISO)
ammonium chloride  (ISO)
apocynin  (EXP,ISO)
arachidonic acid  (ISO)
aristolochic acid  (EXP)
aspartame  (EXP)
astressin  (ISO)
atenolol  (EXP)
atorvastatin calcium  (ISO)
azoxystrobin  (ISO)
bafilomycin A1  (ISO)
benazepril  (EXP,ISO)
benidipine  (EXP)
benzbromarone  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-D-glucosamine  (ISO)
beta-endorphin  (ISO)
biopterin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol F  (ISO)
boric acid  (ISO)
BQ 123  (ISO)
brefeldin A  (ISO)
brimonidine tartrate  (ISO)
Brodifacoum  (ISO)
butan-1-ol  (EXP,ISO)
butanal  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calciol  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
candesartan  (EXP,ISO)
Candesartan cilexetil  (EXP,ISO)
captopril  (EXP,ISO)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
carmustine  (EXP)
carvedilol  (EXP,ISO)
CGP-42112A  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
chromium atom  (ISO)
chymostatin  (EXP,ISO)
ciglitazone  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
clofibric acid  (ISO)
clozapine  (EXP)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP)
corticosterone  (EXP)
cortisol  (EXP)
Cuprizon  (ISO)
curcumin  (ISO)
cyclosporin A  (EXP,ISO)
cypermethrin  (ISO)
D-glucose  (EXP,ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
dibenziodolium  (ISO)
diethyl malate  (ISO)
diminazene diaceturate  (EXP,ISO)
dioxygen  (ISO)
diuron  (ISO)
dopamine  (EXP)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
doxycycline  (ISO)
EC (peptidyl-dipeptidase A) inhibitor  (EXP,ISO)
efonidipine hydrochloride  (EXP)
elcometrine  (EXP)
emodin  (ISO)
enalapril  (EXP,ISO)
enalaprilat dihydrate  (EXP,ISO)
endosulfan  (ISO)
eplerenone  (ISO)
ergosta-4,6,8(14),22-tetraen-3-one  (EXP,ISO)
ethanol  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
famotidine  (ISO)
fenofibrate  (ISO)
flavonoids  (EXP)
flutamide  (ISO)
folic acid  (ISO)
fosinopril  (ISO)
fructose  (ISO)
fulvestrant  (EXP,ISO)
fumonisin B1  (EXP,ISO)
furan  (ISO)
furosemide  (EXP)
genistein  (EXP)
gentamycin  (ISO)
Ginkgoic acid  (ISO)
glucose  (EXP,ISO)
glutathione  (EXP,ISO)
glutathione disulfide  (ISO)
glycerol  (ISO)
glycochenodeoxycholic acid  (ISO)
glyphosate  (ISO)
heparin  (ISO)
hydralazine  (ISO)
hydrazines  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (EXP)
ibuprofen  (ISO)
ICI 118551  (ISO)
imidacloprid  (ISO)
imidaprilat  (ISO)
imperatorin  (ISO)
indometacin  (EXP,ISO)
iohexol  (ISO)
irbesartan  (EXP,ISO)
irinotecan  (EXP)
isoprenaline  (EXP,ISO)
isorhamnetin  (ISO)
Isorhapontigenin  (ISO)
ketamine  (EXP,ISO)
L-ascorbic acid  (EXP,ISO)
L-ethionine  (ISO)
labetalol  (EXP)
lactacystin  (ISO)
lead(0)  (EXP,ISO)
lead(2+)  (EXP,ISO)
levonorgestrel  (EXP)
linoleic acid hydroperoxide  (EXP)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lipoxin A4  (ISO)
lisinopril dihydrate  (EXP,ISO)
losartan  (EXP,ISO)
LY294002  (ISO)
Magnolol  (ISO)
malonaldehyde  (EXP,ISO)
mangiferin  (ISO)
melatonin  (ISO)
mercaptopurine  (ISO)
mercury dichloride  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
methotrexate  (ISO)
methylglyoxal  (ISO)
Mibefradil  (EXP)
microcystin RR  (ISO)
midostaurin  (ISO)
miquelianin  (EXP)
mithramycin  (ISO)
MK-2206  (EXP)
monocrotaline  (ISO)
montelukast  (EXP)
mycophenolic acid  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-desethylamiodarone  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
naloxone  (ISO)
naringin  (EXP)
nebivolol  (ISO)
Neferine  (EXP)
nerolidol  (ISO)
nickel atom  (EXP)
nicorandil  (ISO)
nicotinic acid  (EXP,ISO)
nimesulide  (ISO)
nitric oxide  (EXP,ISO)
nitrites  (ISO)
nitrofen  (ISO)
nitrofurantoin  (ISO)
nitroprusside  (ISO)
NS-398  (ISO)
O-methyleugenol  (EXP)
ochratoxin A  (ISO)
okadaic acid  (ISO)
olmesartan  (EXP,ISO)
omeprazole  (ISO)
ouabain  (ISO)
Pachymic acid  (EXP,ISO)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
PD 168393  (ISO)
PD123319  (EXP,ISO)
perfluorooctanoic acid  (EXP)
perindopril  (EXP,ISO)
peroxynitrous acid  (ISO)
phenylarsine oxide  (ISO)
phenylephrine  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidic acid  (ISO)
phosphoramidon  (ISO)
pindolol  (EXP)
pioglitazone  (ISO)
pirinixic acid  (ISO)
potassium atom  (EXP)
potassium dichromate  (ISO)
pravastatin  (ISO)
pregabalin  (ISO)
progesterone  (EXP,ISO)
propanal  (EXP)
propranolol  (EXP,ISO)
prostaglandin E1  (EXP)
prostaglandin E2  (ISO)
prostaglandin I2  (ISO)
prostaglandins E  (ISO)
purine-6-thiol  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP,ISO)
quinacrine  (ISO)
quinapril hydrochloride  (ISO)
raloxifene  (EXP)
reactive oxygen species  (EXP,ISO)
reboxetine  (EXP)
resveratrol  (EXP,ISO)
rotenone  (EXP,ISO)
rottlerin  (ISO)
rutin  (ISO)
salubrinal  (ISO)
saralasin  (ISO)
SB 203580  (ISO)
scopolamine  (EXP)
sildenafil citrate  (EXP,ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium atom  (EXP,ISO)
sodium chloride  (EXP,ISO)
Soman  (ISO)
spironolactone  (EXP,ISO)
streptozocin  (ISO)
succimer  (EXP)
sucrose  (ISO)
sulforaphane  (ISO)
sunitinib  (EXP)
superoxide  (EXP,ISO)
tamibarotene  (ISO)
tamoxifen  (EXP)
taurine  (ISO)
taurolithocholic acid sulfate  (ISO)
tauroursodeoxycholic acid  (ISO)
telmisartan  (ISO)
temozolomide  (EXP)
testosterone  (ISO)
Testosterone propionate  (ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
thiabendazole  (ISO)
thioacetamide  (ISO)
thiopental  (EXP)
Thiorphan  (ISO)
Tiron  (EXP,ISO)
titanium dioxide  (EXP,ISO)
torasemide  (ISO)
trandolapril  (ISO)
trans-piceid  (ISO)
tributylstannane  (ISO)
trichloroethene  (ISO)
triclosan  (EXP)
troglitazone  (EXP)
tyrphostin AG 1478  (ISO)
U-73122  (ISO)
valproic acid  (EXP,ISO)
valsartan  (EXP,ISO)
Vinpocetine  (ISO)
vismodegib  (EXP)
wortmannin  (ISO)
xestospongin C  (ISO)
zaragozic acid A  (ISO)
zinc atom  (EXP,ISO)
zinc protoporphyrin  (EXP)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of NF-kappaB-inducing kinase activity  (ISO)
activation of phospholipase C activity  (IEA,ISO)
aging  (IEA,ISO)
aldosterone secretion  (ISO)
angiotensin-activated signaling pathway  (IDA)
angiotensin-mediated drinking behavior  (IEA,ISO)
angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure  (ISO)
artery smooth muscle contraction  (IEA,ISO)
associative learning  (IEA,ISO)
astrocyte activation  (ISO)
blood vessel development  (ISO)
blood vessel remodeling  (TAS)
brain renin-angiotensin system  (ISO)
branching involved in ureteric bud morphogenesis  (ISO)
cell growth involved in cardiac muscle cell development  (IEA,ISO)
cell surface receptor signaling pathway  (IEA,ISO)
cell-cell signaling  (TAS)
cell-matrix adhesion  (ISO)
cellular response to angiotensin  (IEA,ISO)
cellular response to mechanical stimulus  (IEA,ISO)
cellular sodium ion homeostasis  (IEA,ISO)
cytokine production  (ISO)
drinking behavior  (ISO)
ERK1 and ERK2 cascade  (IEA,ISO)
establishment of blood-nerve barrier  (ISO)
extracellular matrix organization  (ISO)
female pregnancy  (IEA,ISO)
fibroblast proliferation  (IEA,ISO)
G protein-coupled receptor signaling pathway  (IDA,ISO)
G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger  (TAS)
hormone metabolic process  (ISO)
kidney development  (IMP,ISO)
low-density lipoprotein particle remodeling  (NAS)
maintenance of blood vessel diameter homeostasis by renin-angiotensin  (TAS)
negative regulation of angiogenesis  (IEA,ISO)
negative regulation of cell growth  (IEA,ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of endopeptidase activity  (IBA,IEA)
negative regulation of gene expression  (IDA)
negative regulation of MAP kinase activity  (IMP)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of neurotrophin TRK receptor signaling pathway  (IDA)
negative regulation of sodium ion transmembrane transporter activity  (TAS)
negative regulation of tissue remodeling  (IEA,ISO)
nitric oxide mediated signal transduction  (TAS)
operant conditioning  (IEA,ISO)
ovarian follicle rupture  (ISO)
peristalsis  (ISO)
phospholipase C-activating G protein-coupled receptor signaling pathway  (NAS)
positive regulation of activation of Janus kinase activity  (IMP)
positive regulation of blood pressure  (IEA,ISO)
positive regulation of branching involved in ureteric bud morphogenesis  (IDA)
positive regulation of cardiac muscle cell apoptotic process  (IEA,ISO)
positive regulation of cardiac muscle hypertrophy  (ISS)
positive regulation of catalytic activity  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cellular protein metabolic process  (IDA)
positive regulation of cholesterol esterification  (IDA)
positive regulation of cytokine production  (TAS)
positive regulation of cytosolic calcium ion concentration  (IEA,ISO)
positive regulation of endothelial cell migration  (IDA)
positive regulation of epidermal growth factor receptor signaling pathway  (IDA)
positive regulation of extracellular matrix constituent secretion  (IEA,ISO)
positive regulation of extrinsic apoptotic signaling pathway  (IDA)
positive regulation of fatty acid biosynthetic process  (ISO)
positive regulation of fibroblast proliferation  (ISS)
positive regulation of gap junction assembly  (IGI)
positive regulation of gene expression  (ISO)
positive regulation of inflammatory response  (TAS)
positive regulation of insulin receptor signaling pathway  (IEA,ISO)
positive regulation of L-arginine import across plasma membrane  (IEA,ISO)
positive regulation of L-lysine import across plasma membrane  (IEA,ISO)
positive regulation of macrophage derived foam cell differentiation  (IC)
positive regulation of MAPK cascade  (ISO)
positive regulation of membrane hyperpolarization  (IMP)
positive regulation of multicellular organism growth  (ISO)
positive regulation of NAD(P)H oxidase activity  (TAS)
positive regulation of neuron projection development  (IEA,ISO)
positive regulation of NF-kappaB transcription factor activity  (TAS)
positive regulation of nitric oxide biosynthetic process  (IEA,ISO)
positive regulation of organ growth  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (IDA)
positive regulation of phosphatidylinositol 3-kinase signaling  (IDA)
positive regulation of protein kinase C activity  (ISO)
positive regulation of protein tyrosine kinase activity  (IMP)
positive regulation of reactive oxygen species metabolic process  (TAS)
positive regulation of renal sodium excretion  (IEA,ISO)
positive regulation of superoxide anion generation  (IEA,ISO)
positive regulation of transcription, DNA-templated  (IDA)
positive regulation of vascular associated smooth muscle cell migration  (IEA,ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (IEA,ISO)
protein import into nucleus  (IEA,ISO)
regulation of apoptotic process  (IBA,ISO)
regulation of blood pressure  (IGI,ISO)
regulation of blood volume by renin-angiotensin  (NAS)
regulation of calcium ion transport  (IEA,ISO)
regulation of cardiac conduction  (IGI)
regulation of cell growth  (NAS)
regulation of cell population proliferation  (NAS)
regulation of extracellular matrix assembly  (IGI)
regulation of gene expression  (ISO)
regulation of heart rate  (IEA,ISO)
regulation of inflammatory response  (ISO)
regulation of long-term neuronal synaptic plasticity  (IEA,ISO)
regulation of norepinephrine secretion  (IEA,ISO)
regulation of renal output by angiotensin  (ISO,NAS)
regulation of renal sodium excretion  (ISO,NAS)
regulation of systemic arterial blood pressure by circulatory renin-angiotensin  (ISO)
regulation of systemic arterial blood pressure by renin-angiotensin  (IEA)
regulation of transmission of nerve impulse  (IEA,ISO)
regulation of vasoconstriction  (NAS)
renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure  (ISO)
renal system process  (IDA)
renin-angiotensin regulation of aldosterone production  (ISO,NAS)
response to cold  (ISO)
response to estradiol  (IEA,ISO)
response to muscle activity involved in regulation of muscle adaptation  (ISS)
response to salt stress  (ISO)
smooth muscle cell differentiation  (ISO)
smooth muscle cell proliferation  (IEA,ISO)
stress-activated MAPK cascade  (IEA,ISO)
uterine smooth muscle contraction  (IEA,ISO)
vasoconstriction  (IEA,ISO)
vasodilation  (IEA,ISO)
vasopressin secretion  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
1. Ahmad S, etal., Am J Hypertens. 2009 Dec;22(12):1320-5. doi: 10.1038/ajh.2009.181. Epub 2009 Sep 24.
2. Alokail MS, etal., BMC Cancer. 2013 Feb 4;13:54. doi: 10.1186/1471-2407-13-54.
3. Altarescu G, etal., Biomarkers. 2013 Nov;18(7):595-600. doi: 10.3109/1354750X.2013.836244. Epub 2013 Sep 10.
4. Arumugam S, etal., Toxicology. 2012 Jan 27;291(1-3):139-45. doi: 10.1016/j.tox.2011.11.008. Epub 2011 Nov 23.
5. Barley J, etal., J Hum Hypertens. 1995 Aug;9(8):681-3.
6. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
7. Campbell DJ Int J Biochem Cell Biol. 2003 Jun;35(6):784-91.
8. Cappello M, etal., J Clin Gastroenterol. 2011 Mar;45(3):e25-9. doi: 10.1097/MCG.0b013e3181eb6132.
9. Chen JY, etal., PLoS One. 2012;7(1):e29951. doi: 10.1371/journal.pone.0029951. Epub 2012 Jan 5.
10. Chen L, etal., Eur Rev Med Pharmacol Sci. 2011 Jan;15(1):1-7.
11. Colmenero J, etal., Gastroenterology. 2007 Feb;132(2):687-97. Epub 2006 Dec 20.
12. Cook KL, etal., Cancer Res. 2010 Nov 1;70(21):8319-28. Epub 2010 Sep 13.
13. D'Amore A, etal., Hypertension. 2005 Dec;46(6):1347-54. Epub 2005 Nov 14.
14. da Costa Goncalves AC, etal., Am J Physiol Heart Circ Physiol. 2007 Oct;293(4):H2588-96. Epub 2007 Jul 6.
15. Desong Liu, etal., J Renin Angiotensin Aldosterone Syst. 2010 Dec;11(4):248-55. doi: 10.1177/1470320310374214. Epub 2010 Aug 11.
16. Fan YY, etal., Horm Metab Res. 2013 May;45(5):338-43. doi: 10.1055/s-0032-1331256. Epub 2013 Jan 15.
17. Fatini C, etal., Int J Cardiol. 2008 Jan 24;123(3):293-7. Epub 2007 Mar 26.
18. Fishchuk LE and Gorovenko NG, Exp Oncol. 2013 Jun;35(2):101-4.
19. Fogarty DG, etal., Diabetes. 1996 Sep;45(9):1204-8.
20. Fradin S, etal., Diabetes Metab. 2002 Feb;28(1):27-32.
21. Freitas SR, etal., Braz J Med Biol Res. 2007 Mar;40(3):309-16.
22. Fu H, etal., J Hypertens. 2011 Nov;29(11):2210-9. doi: 10.1097/HJH.0b013e32834bbb30.
23. Gargano JW, etal., Am J Obstet Gynecol. 2009 Sep;201(3):317.e1-9. doi: 10.1016/j.ajog.2009.05.060.
24. GOA_HUMAN data from the GO Consortium
25. Gonzalez-Zuloeta Ladd AM, etal., Breast Cancer Res Treat. 2007 Mar;101(3):299-304. Epub 2006 Jul 6.
26. Gopi Chand M, etal., Biochem Genet. 2011 Feb 11.
27. Goto M, etal., Pediatr Nephrol. 2010 Dec;25(12):2449-57. doi: 10.1007/s00467-010-1621-z. Epub 2010 Aug 27.
28. Gouveia TL, etal., Neurochem Int. 2012 Jul;61(1):54-62. doi: 10.1016/j.neuint.2012.04.012. Epub 2012 Apr 20.
29. Greco M, etal., Cancer Lett. 2009 Oct 8;283(2):222-9. doi: 10.1016/j.canlet.2009.04.001. Epub 2009 Apr 25.
30. Gutierrez C, etal., Metabolism. 1997 Aug;46(8):976-80.
31. Hager A, etal., Eur J Prev Cardiol. 2012 Apr;19(2):199-204. doi: 10.1177/1741826711399991. Epub 2011 Feb 25.
32. Hegele RA, etal., Clin Biochem. 1999 Aug;32(6):429-37.
33. Herath CB, etal., J Hepatol. 2007 Sep;47(3):387-95. Epub 2007 Apr 2.
34. Hering L, etal., Hypertension. 2010 Aug;56(2):311-8. doi: 10.1161/HYPERTENSIONAHA.110.150961. Epub 2010 Jun 7.
35. Hermann K, etal., Clin Exp Allergy. 1992 Sep;22(9):845-53.
36. Hodroj W, etal., Arterioscler Thromb Vasc Biol. 2007 Mar;27(3):525-31. Epub 2006 Dec 14.
37. Holla L, etal., J Allergy Clin Immunol. 1999 Apr;103(4):702-8.
38. Hong F, etal., Int J Cardiol. 2011 Apr 1;148(1):76-84. doi: 10.1016/j.ijcard.2009.10.027. Epub 2009 Nov 24.
39. Hunyady L and Catt KJ, Mol Endocrinol. 2006 May;20(5):953-70. Epub 2005 Sep 1.
40. Igase M, etal., Ther Adv Cardiovasc Dis. 2011 Dec;5(6):297-304. doi: 10.1177/1753944711429343. Epub 2011 Nov 16.
41. Imauchi Y, etal., Otol Neurotol. 2008 Apr;29(3):295-301.
42. Ishanov A, etal., Am Heart J. 1997 Feb;133(2):184-9.
43. Jeunemaitre X, etal., Cell 1992 Oct 2;71(1):169-80.
44. Kang YM, etal., Toxicol Appl Pharmacol. 2014 Feb 1;274(3):436-44. doi: 10.1016/j.taap.2013.12.001. Epub 2013 Dec 14.
45. Kasselman LJ and Rutkove SB, Muscle Nerve. 2010 Dec;42(6):959-65. doi: 10.1002/mus.21767. Epub 2010 Sep 30.
46. Kawaguchi Y, etal., Arthritis Rheum. 2004 Jan;50(1):216-26.
47. Kim HJ, etal., J Pharmacol Exp Ther. 2011 Feb 25.
48. Kobori H, etal., J Am Soc Nephrol. 2005 Jul;16(7):2073-80. Epub 2005 May 11.
49. Kramar EA, etal., Brain Res. 2001 Apr 6;897(1-2):114-21.
50. Lam SY, etal., Exp Physiol. 2014 Jan;99(1):220-31. doi: 10.1113/expphysiol.2013.074591. Epub 2013 Sep 13.
51. Leckie BJ Curr Med Chem Cardiovasc Hematol Agents. 2005 Jan;3(1):23-32.
52. Li L, etal., Cardiovasc Res. 2011 Mar 2.
53. Liu L, etal., Am J Physiol Renal Physiol. 2011 Dec;301(6):F1195-201. doi: 10.1152/ajprenal.00339.2011. Epub 2011 Aug 24.
54. Lochard N, etal., J Biol Chem 2003 Jan 24;278(4):2184-9. Epub 2002 Oct 23.
55. Lu J, etal., Neuropeptides. 2013 Oct;47(5):289-95. doi: 10.1016/j.npep.2013.09.002. Epub 2013 Sep 18.
56. Lu P, etal., Int J Clin Exp Pathol. 2012;5(7):698-706. Epub 2012 Sep 5.
57. Lu P, etal., Med Sci Monit. 2011 Sep;17(9):BR248-56.
58. Lukkarinen H, etal., Pediatr Res. 2004 Feb;55(2):326-33. Epub 2003 Nov 6.
59. Ma LQ, etal., Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2006 Dec;28(6):770-5.
60. Marco J, etal., Nefrologia. 2005;25(6):629-36.
61. Mateos L, etal., J Alzheimers Dis. 2011 Feb 4.
62. Meng Y, etal., Am J Respir Cell Mol Biol. 2014 Apr;50(4):723-36. doi: 10.1165/rcmb.2012-0451OC.
63. Mukohda M, etal., J Pharmacol Sci. 2010;114(4):390-8. Epub 2010 Nov 9.
64. Murano Y, etal., Pediatr Res. 2015 Dec;78(6):678-82. doi: 10.1038/pr.2015.153. Epub 2015 Aug 13.
65. Neri Serneri GG, etal., J Am Coll Cardiol. 2001 Jul;38(1):49-55.
66. Neves LA, etal., Am J Physiol Regul Integr Comp Physiol. 2008 Jan;294(1):R151-61. Epub 2007 Oct 31.
67. Olivieri O, etal., J Hypertens. 2001 May;19(5):879-84.
68. OMIM Disease Annotation Pipeline
69. Ozkaya O, etal., Clin Rheumatol. 2006 Nov;25(6):861-5. Epub 2006 Mar 7.
70. Padia SH and Carey RM, Pflugers Arch. 2013 Jan;465(1):99-110. doi: 10.1007/s00424-012-1146-3. Epub 2012 Sep 5.
71. Padia SH, etal., Hypertension. 2006 Mar;47(3):537-44. Epub 2005 Dec 27.
72. Padro-Miquel A, etal., Clin Biochem. 2009 Jan;42(1-2):5-11. doi: 10.1016/j.clinbiochem.2008.10.011. Epub 2008 Nov 5.
73. Peng J, etal., Regul Pept 2002 Dec 31;110(1):25-32.
74. Peng JF, etal., Hypertension. 1998 Jun;31(6):1317-23.
75. Petkeviciene J, etal., PLoS One. 2014 Oct 14;9(10):e109974. doi: 10.1371/journal.pone.0109974. eCollection 2014.
76. Pignone A, etal., Ann Rheum Dis. 2007 Oct;66(10):1305-10. Epub 2007 Mar 14.
77. Pilbrow AP, etal., Hypertension. 2007 Feb;49(2):322-7. Epub 2006 Dec 4.
78. Pipeline to import KEGG annotations from KEGG into RGD
79. Pipeline to import SMPDB annotations from SMPDB into RGD
80. Procopciuc LM, etal., Rom J Intern Med. 2005;43(1-2):61-71.
81. Reaux A, etal., Trends Endocrinol Metab. 2001 May-Jun;12(4):157-62.
82. Reudelhuber TL Hypertension. 2005 Dec;46(6):1261-2. Epub 2005 Nov 14.
83. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
84. RGD automated import pipeline for gene-chemical interactions
85. RGD automated import pipeline for human HPO-to-gene-to-disease annotations
86. Riaz AA, etal., FASEB J. 2004 May;18(7):881-3. doi: 10.1096/fj.03-0502fje. Epub 2004 Mar 4.
87. Rijn MJ, etal., J Neurol Neurosurg Psychiatry. 2007 Jan 12;.
88. Rodriguez-Campos M, etal., Cell Mol Neurobiol. 2000 Dec;20(6):747-62.
89. Rojas M, etal., Invest Ophthalmol Vis Sci. 2010 Mar;51(3):1709-18. doi: 10.1167/iovs.09-3375. Epub 2009 Oct 15.
90. Sayitoglu M, etal., J Int Med Res. 2009 Jul-Aug;37(4):1018-28.
91. Schelleman H, etal., Eur J Hum Genet. 2007 Apr;15(4):478-84. Epub 2007 Feb 14.
92. Schrauwen I, etal., Otol Neurotol. 2009 Dec;30(8):1079-83. doi: 10.1097/MAO.0b013e3181ab3058.
93. Stobdan T, etal., J Renin Angiotensin Aldosterone Syst. 2011 Mar 10.
94. Sui YB, etal., Peptides. 2013 Apr;42:25-34. doi: 10.1016/j.peptides.2012.12.023. Epub 2013 Jan 3.
95. Susic D, etal., J Hypertens. 2011 Apr;29(4):716-23.
96. Takakura Y, etal., Metabolism. 2006 Jun;55(6):819-24.
97. Tallant EA, etal., Am J Physiol Heart Circ Physiol. 2005 Oct;289(4):H1560-6. Epub 2005 Jun 10.
98. Tang DC, etal., Am J Hematol. 2001 Nov;68(3):164-9.
99. Tsai CT, etal., Cardiology. 2008;111(1):1-7. doi: 10.1159/000113419. Epub 2008 Feb 1.
100. Tsuchida S, etal., J Clin Invest 1998 Feb 15;101(4):755-60.
101. Urushihara M, etal., Hypertension. 2011 Mar;57(3):586-93. Epub 2011 Jan 31.
102. Usui T, etal., Invest Ophthalmol Vis Sci. 2008 Oct;49(10):4370-6. doi: 10.1167/iovs.07-0964.
103. van Ittersum FJ, etal., Nephrol Dial Transplant. 2000 Jul;15(7):1000-7.
104. Velez DR, etal., Am J Hypertens. 2006 Dec;19(12):1278-85.
105. Verma A, etal., Mol Ther. 2012 Jan;20(1):28-36. doi: 10.1038/mt.2011.155. Epub 2011 Jul 26.
106. Ward K, etal., Nat Genet 1993 May;4(1):59-61.
107. Wosik K, etal., J Neurosci. 2007 Aug 22;27(34):9032-42.
108. Yamada Y, etal., Am J Hypertens. 1997 Aug;10(8):921-8.
109. Yang C, etal., PLoS One. 2014 Jan 21;9(1):e85785. doi: 10.1371/journal.pone.0085785. eCollection 2014.
110. Yayama K, etal., Biol Pharm Bull. 1995 Mar;18(3):411-5.
111. Yayama K, etal., Nephron. 1993;63(1):89-93.
112. Zeng WT, etal., Cardiovasc Ther. 2010 Dec 19. doi: 10.1111/j.1755-5922.2010.00255.x.
113. Zhu D, etal., Biochem Pharmacol. 2014 Feb 1;87(3):467-76. doi: 10.1016/j.bcp.2013.10.026. Epub 2013 Nov 11.
114. Zong WN, etal., Acta Pharmacol Sin. 2011 Nov;32(11):1345-50. doi: 10.1038/aps.2011.96. Epub 2011 Oct 3.
Additional References at PubMed
PMID:12173   PMID:28321   PMID:1132082   PMID:1378723   PMID:1692023   PMID:1756856   PMID:2286380   PMID:2834384   PMID:2885106   PMID:2924688   PMID:3034901   PMID:3397061  
PMID:3579322   PMID:3934016   PMID:4300938   PMID:6089875   PMID:7259779   PMID:7539791   PMID:7607642   PMID:7744780   PMID:7888785   PMID:7961807   PMID:8125298   PMID:8185599  
PMID:8230088   PMID:8477848   PMID:8548433   PMID:8621667   PMID:8959747   PMID:9120024   PMID:9492317   PMID:9694881   PMID:9757569   PMID:9814470   PMID:10406457   PMID:10419812  
PMID:10619573   PMID:10899625   PMID:10969042   PMID:11024214   PMID:11027844   PMID:11053482   PMID:11082147   PMID:11095476   PMID:11096141   PMID:11106322   PMID:11114694   PMID:11136175  
PMID:11142763   PMID:11157174   PMID:11181802   PMID:11191642   PMID:11200871   PMID:11208365   PMID:11213892   PMID:11230286   PMID:11234373   PMID:11244011   PMID:11278902   PMID:11288810  
PMID:11300226   PMID:11317203   PMID:11325075   PMID:11330506   PMID:11330874   PMID:11341749   PMID:11345362   PMID:11354780   PMID:11355019   PMID:11359462   PMID:11372768   PMID:11422735  
PMID:11422818   PMID:11431175   PMID:11447495   PMID:11463770   PMID:11484170   PMID:11507973   PMID:11531970   PMID:11544438   PMID:11575217   PMID:11577832   PMID:11593098   PMID:11668351  
PMID:11675943   PMID:11677359   PMID:11677365   PMID:11688760   PMID:11689223   PMID:11707217   PMID:11707427   PMID:11707686   PMID:11709400   PMID:11711524   PMID:11714857   PMID:11720807  
PMID:11725160   PMID:11731937   PMID:11737220   PMID:11747312   PMID:11751698   PMID:11756575   PMID:11776100   PMID:11803527   PMID:11815627   PMID:11849656   PMID:11860821   PMID:11862023  
PMID:11865575   PMID:11882570   PMID:11910300   PMID:11910301   PMID:11918988   PMID:11923478   PMID:11923700   PMID:11924723   PMID:11926202   PMID:11963567   PMID:11997278   PMID:12006677  
PMID:12015946   PMID:12031704   PMID:12037699   PMID:12040348   PMID:12045255   PMID:12051013   PMID:12081721   PMID:12082592   PMID:12095411   PMID:12118911   PMID:12130713   PMID:12145290  
PMID:12164881   PMID:12169209   PMID:12173461   PMID:12181363   PMID:12181364   PMID:12187393   PMID:12194787   PMID:12205735   PMID:12234952   PMID:12270765   PMID:12352892   PMID:12394950  
PMID:12417054   PMID:12425365   PMID:12426159   PMID:12431442   PMID:12446192   PMID:12446468   PMID:12449516   PMID:12450315   PMID:12454231   PMID:12469628   PMID:12476421   PMID:12476891  
PMID:12477932   PMID:12479284   PMID:12482638   PMID:12511523   PMID:12511525   PMID:12513040   PMID:12536339   PMID:12544508   PMID:12548125   PMID:12556231   PMID:12559679   PMID:12569265  
PMID:12575194   PMID:12576245   PMID:12579398   PMID:12579405   PMID:12597535   PMID:12611423   PMID:12624946   PMID:12627873   PMID:12661912   PMID:12663441   PMID:12663475   PMID:12669427  
PMID:12670743   PMID:12675870   PMID:12695419   PMID:12716844   PMID:12728975   PMID:12743009   PMID:12767551   PMID:12805070   PMID:12811821   PMID:12819040   PMID:12829792   PMID:12830507  
PMID:12832734   PMID:12854169   PMID:12865608   PMID:12874613   PMID:12888892   PMID:12895663   PMID:12898858   PMID:12911327   PMID:12911556   PMID:12932862   PMID:12938141   PMID:12939534  
PMID:12950120   PMID:12964504   PMID:14500990   PMID:14502296   PMID:14508190   PMID:14508191   PMID:14519430   PMID:14521795   PMID:14523024   PMID:14530292   PMID:14565954   PMID:14569094  
PMID:14597849   PMID:14610337   PMID:14625185   PMID:14638622   PMID:14642613   PMID:14643573   PMID:14643574   PMID:14644777   PMID:14648325   PMID:14660489   PMID:14669517   PMID:14672953  
PMID:14688807   PMID:14700505   PMID:14718574   PMID:14749533   PMID:14765837   PMID:14767013   PMID:14767903   PMID:14961043   PMID:14970360   PMID:14973087   PMID:14997233   PMID:15013293  
PMID:15013322   PMID:15013333   PMID:15017542   PMID:15023884   PMID:15031629   PMID:15042429   PMID:15044674   PMID:15045574   PMID:15055256   PMID:15062885   PMID:15067378   PMID:15067738  
PMID:15075192   PMID:15076187   PMID:15077204   PMID:15079791   PMID:15082899   PMID:15097234   PMID:15108186   PMID:15112434   PMID:15112973   PMID:15120696   PMID:15123355   PMID:15130920  
PMID:15131005   PMID:15149328   PMID:15153556   PMID:15153745   PMID:15192838   PMID:15201544   PMID:15201545   PMID:15278435   PMID:15283675   PMID:15294367   PMID:15317677   PMID:15326089  
PMID:15343353   PMID:15353577   PMID:15364762   PMID:15385810   PMID:15386947   PMID:15387996   PMID:15388495   PMID:15448113   PMID:15489334   PMID:15498133   PMID:15504143   PMID:15505642  
PMID:15563875   PMID:15575510   PMID:15599691   PMID:15614026   PMID:15621215   PMID:15624175   PMID:15628301   PMID:15642127   PMID:15649942   PMID:15652490   PMID:15659127   PMID:15662219  
PMID:15668245   PMID:15673342   PMID:15676177   PMID:15718424   PMID:15718497