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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731070
Species: Homo sapiens
RGD Object: Gene
Symbol: AGT
Name: angiotensinogen
Acc ID: CHEBI:2469
Term: adefovir
Definition: A member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens has been replaced by a 2-(6-amino-9H-purin-9-yl)ethoxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(t-butoxycarbonyloxymethyl) ester (dipivoxil ester) prodrug is used to treat chronic hepatitis B viral infection.
Chemical ID: MESH:C053001
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AGTmultiple interactionsISOAgt (Rattus norvegicus)6480464CTD[Probenecid co-treated with adefovir] results in increased expression of AGT protein; [Probenecid co-treated with Valsartan co-treated with adefovir] results in increased expression of AGT protein; Cromolyn Sodium inhibits the reaction [[Probenecid co-treated with adefovir] results in increased expression of AGT protein]PMID:35114312
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