Agt (angiotensinogen (serpin peptidase inhibitor, clade A, member 8)) - Rat Genome Database
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Gene: Agt (angiotensinogen (serpin peptidase inhibitor, clade A, member 8)) Mus musculus
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Symbol: Agt
Name: angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
RGD ID: 10118
MGI Page MGI
Description: Exhibits type 1 angiotensin receptor binding activity and type 2 angiotensin receptor binding activity. Involved in several processes, including nervous system development; positive regulation of protein phosphorylation; and regulation of systemic arterial blood pressure by renin-angiotensin. Localizes to extracellular space. Is expressed in several structures, including axial skeleton; central nervous system; foregut mesenchyme; genitourinary system; and liver. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Henoch-Schoenlein purpura; artery disease (multiple); heart conduction disease (multiple); and hydronephrosis. Orthologous to human AGT (angiotensinogen); PARTICIPATES IN angiotensin (1-7) signaling pathway; angiotensin II signaling pathway via AT2 receptor; angiotensin III signaling pathway; INTERACTS WITH (+)-alpha-tocopherol; (+)-taxifolin; (R)-lipoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI265500; AngI; AngII; angiotensin I; angiotensin ll; angiotensinogen; Ao; Aogen; Se; serpin A8; Serpina8
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398125,283,326 - 125,296,445 (-)NCBIGRCm39mm39
GRCm39 Ensembl8125,283,273 - 125,296,445 (-)Ensembl
GRCm388124,556,587 - 124,569,706 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8124,556,534 - 124,569,706 (-)EnsemblGRCm38mm10GRCm38
MGSCv378127,080,487 - 127,093,607 (-)NCBIGRCm37mm9NCBIm37
MGSCv368127,442,677 - 127,455,773 (-)NCBImm8
Celera8128,860,995 - 128,873,954 (-)NCBICelera
Cytogenetic Map8E2NCBI
cM Map872.81NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Albuminuria  (ISO)
alcoholic cardiomyopathy  (ISO)
alcoholic hepatitis  (ISO)
Alkalosis  (ISO)
Allanson Pantzar McLeod Syndrome  (ISO)
allergic disease  (ISO)
Alzheimer's disease  (ISO)
Anaphylaxis  (ISO)
anemia  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
anuria  (ISO)
aortic aneurysm  (ISO)
Aortic Calcification  (ISO)
Aortic Coarctation  (ISO)
atherosclerosis  (ISO)
atrial fibrillation  (ISO)
bipolar disorder  (ISO)
Bradycardia  (ISO)
breast cancer  (ISO)
Cardiac Arrhythmias  (ISO)
Cardiomegaly  (IDA,ISO)
cardiomyopathy  (ISO)
Cardiovascular Abnormalities  (ISO)
cardiovascular system disease  (ISO)
carotid artery disease  (ISO)
Catalepsy  (ISO)
cerebrovascular disease  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholestasis  (ISO)
Chronic Intermittent Hypoxia  (ISO)
chronic myeloid leukemia  (ISO)
cognitive disorder  (ISO)
congestive heart failure  (ISO)
corneal neovascularization  (IEP)
coronary artery disease  (ISO)
COVID-19  (ISO)
Crohn's disease  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (IMP,ISO)
Diaphragmatic Hernia  (ISO)
diffuse scleroderma  (ISO)
dilated cardiomyopathy  (ISO)
Dissecting Aneurysm  (ISO)
Drug Overdose  (ISO)
end stage renal disease  (ISO)
endomyocardial fibrosis  (ISO)
essential hypertension  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Fabry disease  (ISO)
Fetal Growth Retardation  (ISO)
Fibrosis  (ISO)
focal segmental glomerulosclerosis  (ISO)
gastric ulcer  (ISO)
glomerulonephritis  (ISO)
glucose intolerance  (ISO)
heart disease  (ISO)
Hemorrhage  (ISO)
Henoch-Schoenlein purpura  (ISO)
hydronephrosis  (IMP,ISO)
Hyperalgesia  (ISO)
Hyperemia  (ISO)
hyperhomocysteinemia  (ISO)
hyperinsulinism  (ISO)
hypertension  (IDA,ISO)
Hypertensive Nephropathy  (ISO)
hypertrophic cardiomyopathy  (ISO)
Hypertrophy  (ISO)
hypokalemia  (ISO)
Hypotension  (IMP,ISO)
IgA glomerulonephritis  (ISO)
impotence  (ISO)
Inflammation  (ISO)
inflammatory bowel disease  (ISO)
intermediate coronary syndrome  (ISO)
Intestinal Reperfusion Injury  (ISO)
kidney disease  (ISO)
kidney failure  (ISO)
Left Ventricular Hypertrophy  (ISO)
liver cirrhosis  (ISO)
malignant hypertension  (ISO)
Mammary Neoplasms, Experimental  (IDA)
meconium aspiration syndrome  (ISO)
Metabolic Syndrome  (ISO)
microcephaly  (ISO)
middle cerebral artery infarction  (ISO)
mitral valve prolapse  (ISO)
multiple sclerosis  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
Necrosis  (ISO)
Neointima  (ISO)
nephrosis  (ISO)
Neurobehavioral Manifestations  (ISO)
obesity  (ISO)
otosclerosis  (ISO)
parathyroid carcinoma  (ISO)
Peptic Ulcer Hemorrhage  (ISO)
pneumonia  (ISO)
polycystic kidney disease  (ISO)
pre-eclampsia  (ISO)
prediabetes syndrome  (ISO)
Pregnancy-Induced Hypertension  (ISO)
primary biliary cholangitis  (ISO)
proteinuria  (ISO)
pulmonary edema  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
Puromycin Aminonucleoside Nephrosis  (ISO)
renal hypertension  (ISO)
Renal Tubular Dysgenesis  (ISO)
Reperfusion Injury  (ISO)
retinal vasculitis  (IDA)
retinopathy of prematurity  (ISO)
sciatic neuropathy  (ISO)
sick sinus syndrome  (ISO)
skin melanoma  (ISO)
Stroke  (ISO)
Sudden Death  (ISO)
systemic scleroderma  (ISO)
temporal lobe epilepsy  (ISO)
thrombosis  (ISO)
transient cerebral ischemia  (ISO)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (ISO)
vascular disease  (ISO)
Vascular Remodeling  (ISO)
Ventricular Dysfunction, Left  (ISO)
Ventricular Remodeling  (ISO)
visual epilepsy  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-tocopherol  (EXP)
(+)-catechin  (ISO)
(+)-taxifolin  (EXP)
(R)-lipoic acid  (EXP)
(R)-mevalonic acid  (ISO)
(R)-noradrenaline  (ISO)
(S)-amphetamine  (EXP)
1,2-dichloroethane  (EXP)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (ISO)
11-deoxycorticosterone  (ISO)
11-Hydroxyandrostenedione  (ISO)
14,15-EET  (EXP,ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2,6-dinitrotoluene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
3',5'-cyclic GMP  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (ISO)
3,7-dihydropurine-6-thione  (ISO)
3-[3-acetyl-4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl]-1,1-diethylurea  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroperoxycyclophosphamide  (ISO)
4-hydroxynon-2-enal  (ISO)
4-phenylbutyric acid  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-oxoprostaglandin F1alpha  (ISO)
6-propyl-2-thiouracil  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP,ISO)
8-Br-cAMP  (ISO)
8-hydroxy-2'-deoxyguanosine  (ISO)
AACOCF3  (ISO)
acetamide  (ISO)
acetylcholine  (EXP)
acetylsalicylic acid  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (ISO)
aldosterone  (EXP,ISO)
aliskiren  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
allopurinol  (ISO)
alpha-cyano-4-hydroxycinnamic acid  (ISO)
amidotrizoic acid  (ISO)
amiloride  (ISO)
amiodarone  (ISO)
amitrole  (ISO)
amlodipine  (ISO)
ammonia  (EXP)
ammonium chloride  (ISO)
ANTIMYCIN  (ISO)
apocynin  (EXP,ISO)
arachidonic acid  (EXP)
aspartame  (ISO)
atenolol  (ISO)
atorvastatin calcium  (ISO)
bafilomycin A1  (ISO)
BAPTA  (EXP)
benazepril  (ISO)
benidipine  (ISO)
benzbromarone  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-D-glucosamine  (EXP)
biopterin  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol F  (EXP)
boric acid  (EXP)
BQ 123  (EXP,ISO)
brefeldin A  (ISO)
brimonidine tartrate  (ISO)
Brodifacoum  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
caffeine  (ISO)
calciol  (EXP)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
candesartan  (EXP,ISO)
Candesartan cilexetil  (ISO)
captopril  (EXP,ISO)
carbon monoxide  (EXP)
carbon nanotube  (EXP)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
carmustine  (ISO)
carvedilol  (ISO)
CCCP  (ISO)
CGP-42112A  (EXP)
chlorpyrifos  (EXP)
cholesterol  (EXP,ISO)
chromium atom  (ISO)
chymostatin  (EXP,ISO)
ciglitazone  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP,ISO)
clofibric acid  (ISO)
clozapine  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
corticosterone  (ISO)
cortisol  (ISO)
curcumin  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cypermethrin  (ISO)
D-glucose  (ISO)
DDE  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
dibenziodolium  (EXP,ISO)
diethyl malate  (EXP)
diminazene diaceturate  (EXP,ISO)
dioxygen  (EXP,ISO)
diuron  (ISO)
dopamine  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (ISO)
doxycycline  (ISO)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (ISO)
efonidipine hydrochloride  (ISO)
elcometrine  (ISO)
emodin  (ISO)
enalapril  (EXP,ISO)
enalaprilat dihydrate  (ISO)
endosulfan  (ISO)
eplerenone  (EXP)
ergosta-4,6,8(14),22-tetraen-3-one  (EXP,ISO)
ethanol  (EXP,ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
famotidine  (ISO)
fenofibrate  (EXP)
flavonoids  (ISO)
flutamide  (ISO)
folic acid  (EXP,ISO)
fosinopril  (ISO)
fructose  (EXP,ISO)
fulvestrant  (ISO)
fumonisin B1  (EXP,ISO)
furan  (ISO)
furosemide  (ISO)
genistein  (ISO)
gentamycin  (ISO)
Ginkgoic acid  (EXP)
glucose  (ISO)
glutathione  (EXP,ISO)
glutathione disulfide  (EXP)
glycerol  (ISO)
glycochenodeoxycholic acid  (ISO)
heparin  (ISO)
hydralazine  (EXP,ISO)
hydrazines  (EXP)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
ibuprofen  (ISO)
ICI 118551  (EXP)
imidaprilat  (EXP)
imperatorin  (ISO)
indometacin  (ISO)
iohexol  (ISO)
irbesartan  (EXP,ISO)
irinotecan  (ISO)
isoprenaline  (EXP,ISO)
isorhamnetin  (ISO)
Isorhapontigenin  (ISO)
ketamine  (ISO)
L-ascorbic acid  (ISO)
L-ethionine  (ISO)
labetalol  (ISO)
lactacystin  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
levonorgestrel  (ISO)
linoleic acid hydroperoxide  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
lipoxin A4  (EXP)
lisinopril dihydrate  (ISO)
losartan  (EXP,ISO)
LY294002  (ISO)
Magnolol  (ISO)
malonaldehyde  (EXP,ISO)
mangiferin  (ISO)
melatonin  (ISO)
mercaptopurine  (ISO)
mercury dichloride  (ISO)
metformin  (EXP)
methotrexate  (EXP)
methylglyoxal  (ISO)
Mibefradil  (ISO)
microcystin RR  (EXP)
midostaurin  (ISO)
miquelianin  (ISO)
mithramycin  (ISO)
MK-2206  (ISO)
monocrotaline  (ISO)
montelukast  (ISO)
mycophenolic acid  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
naringin  (ISO)
nebivolol  (ISO)
nerolidol  (ISO)
nickel atom  (ISO)
nicorandil  (EXP)
nicotinic acid  (EXP,ISO)
nimesulide  (EXP)
nitric oxide  (EXP,ISO)
nitrites  (ISO)
nitrofen  (ISO)
nitrofurantoin  (ISO)
nitroprusside  (EXP)
NS-398  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
okadaic acid  (EXP)
olmesartan  (ISO)
omeprazole  (ISO)
ouabain  (ISO)
Pachymic acid  (EXP,ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PD 168393  (ISO)
PD123319  (EXP,ISO)
perfluorooctanoic acid  (ISO)
perindopril  (ISO)
peroxynitrous acid  (EXP)
phenylarsine oxide  (ISO)
phenylephrine  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
phosphatidic acid  (ISO)
phosphoramidon  (ISO)
pindolol  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
potassium atom  (ISO)
potassium dichromate  (EXP)
pravastatin  (EXP,ISO)
pregabalin  (ISO)
progesterone  (EXP,ISO)
propanal  (ISO)
propranolol  (EXP,ISO)
prostaglandin E1  (ISO)
prostaglandin E2  (ISO)
prostaglandin I2  (ISO)
prostaglandins E  (ISO)
purine-6-thiol  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP,ISO)
quinacrine  (EXP)
quinapril hydrochloride  (ISO)
raloxifene  (ISO)
reactive oxygen species  (EXP,ISO)
reboxetine  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP,ISO)
rottlerin  (ISO)
rutin  (ISO)
salubrinal  (ISO)
saralasin  (ISO)
SB 203580  (EXP,ISO)
scopolamine  (ISO)
sildenafil citrate  (EXP,ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium atom  (ISO)
sodium chloride  (ISO)
Soman  (ISO)
spironolactone  (ISO)
streptozocin  (EXP,ISO)
succimer  (ISO)
sucrose  (ISO)
sulforaphane  (EXP)
sunitinib  (ISO)
superoxide  (EXP,ISO)
tamibarotene  (EXP)
tamoxifen  (ISO)
taurine  (ISO)
taurolithocholic acid sulfate  (ISO)
tauroursodeoxycholic acid  (ISO)
telmisartan  (EXP,ISO)
temozolomide  (ISO)
testosterone  (ISO)
Testosterone propionate  (ISO)
tetrachloromethane  (ISO)
tetracycline  (EXP)
thioacetamide  (ISO)
thiopental  (ISO)
Thiorphan  (EXP)
Tiron  (EXP,ISO)
titanium dioxide  (EXP,ISO)
torasemide  (ISO)
trandolapril  (EXP,ISO)
trans-piceid  (ISO)
tributylstannane  (EXP,ISO)
trichloroethene  (ISO)
triclosan  (ISO)
troglitazone  (ISO)
tyrphostin AG 1478  (ISO)
U-73122  (ISO)
valproic acid  (EXP,ISO)
valsartan  (EXP,ISO)
Vinpocetine  (ISO)
vismodegib  (ISO)
vitamin E  (EXP)
wortmannin  (ISO)
xestospongin C  (ISO)
zaragozic acid A  (EXP,ISO)
zinc atom  (ISO)
zinc protoporphyrin  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of MAPK activity  (ISO)
activation of NF-kappaB-inducing kinase activity  (IDA)
activation of phospholipase C activity  (ISO)
aging  (ISO)
angiotensin-activated signaling pathway  (ISO)
angiotensin-mediated drinking behavior  (ISO)
angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure  (IDA)
artery smooth muscle contraction  (ISO)
associative learning  (ISO)
astrocyte activation  (IMP)
blood vessel development  (IMP)
brain renin-angiotensin system  (IDA)
branching involved in ureteric bud morphogenesis  (IDA,IMP)
cell growth involved in cardiac muscle cell development  (ISO)
cell surface receptor signaling pathway  (ISO)
cell-matrix adhesion  (IMP)
cellular response to angiotensin  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular sodium ion homeostasis  (ISO)
cytokine production  (ISO)
drinking behavior  (IMP)
ERK1 and ERK2 cascade  (ISO)
establishment of blood-nerve barrier  (IMP)
excretion  (IMP)
extracellular matrix organization  (IMP)
female pregnancy  (ISO)
fibroblast proliferation  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
hormone metabolic process  (IMP)
kidney development  (IMP,ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of cell population proliferation  (IMP)
negative regulation of endopeptidase activity  (IBA)
negative regulation of gene expression  (ISO)
negative regulation of MAP kinase activity  (ISO)
negative regulation of neuron apoptotic process  (IMP)
negative regulation of neurotrophin TRK receptor signaling pathway  (ISO)
negative regulation of tissue remodeling  (ISO)
operant conditioning  (ISO)
ovarian follicle rupture  (IMP)
peristalsis  (IMP)
positive regulation of activation of Janus kinase activity  (ISO)
positive regulation of blood pressure  (ISO)
positive regulation of branching involved in ureteric bud morphogenesis  (ISO)
positive regulation of cardiac muscle cell apoptotic process  (ISO)
positive regulation of cardiac muscle hypertrophy  (ISO)
positive regulation of catalytic activity  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cellular protein metabolic process  (ISO)
positive regulation of cholesterol esterification  (ISO)
positive regulation of cytokine production  (IMP)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of endothelial cell migration  (ISO)
positive regulation of epidermal growth factor receptor signaling pathway  (ISO)
positive regulation of extracellular matrix constituent secretion  (ISO)
positive regulation of extrinsic apoptotic signaling pathway  (ISO)
positive regulation of fatty acid biosynthetic process  (IMP)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of gap junction assembly  (ISO)
positive regulation of gene expression  (IDA)
positive regulation of insulin receptor signaling pathway  (ISO)
positive regulation of L-arginine import across plasma membrane  (ISO)
positive regulation of L-lysine import across plasma membrane  (ISO)
positive regulation of MAPK cascade  (IMP)
positive regulation of membrane hyperpolarization  (ISO)
positive regulation of multicellular organism growth  (IMP)
positive regulation of neuron projection development  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of organ growth  (IDA,IMP)
positive regulation of peptidyl-serine phosphorylation  (IDA)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase signaling  (ISO)
positive regulation of protein kinase C activity  (IDA)
positive regulation of protein tyrosine kinase activity  (ISO)
positive regulation of renal sodium excretion  (ISO)
positive regulation of superoxide anion generation  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
positive regulation of vascular associated smooth muscle cell migration  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
protein import into nucleus  (ISO)
regulation of apoptotic process  (IBA,IDA,ISO)
regulation of blood pressure  (IMP,ISO)
regulation of calcium ion transport  (ISO)
regulation of cardiac conduction  (ISO)
regulation of extracellular matrix assembly  (ISO)
regulation of gene expression  (IDA)
regulation of heart rate  (ISO)
regulation of inflammatory response  (IDA,IGI)
regulation of long-term neuronal synaptic plasticity  (ISO)
regulation of norepinephrine secretion  (ISO)
regulation of renal output by angiotensin  (IMP)
regulation of renal sodium excretion  (ISO)
regulation of systemic arterial blood pressure by circulatory renin-angiotensin  (IMP)
regulation of transmission of nerve impulse  (ISO)
renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure  (IMP)
renal system process  (ISO)
renin-angiotensin regulation of aldosterone production  (IMP,ISO)
response to cold  (IMP)
response to estradiol  (ISO)
response to muscle activity involved in regulation of muscle adaptation  (ISO)
response to salt stress  (IMP)
smooth muscle cell differentiation  (IDA,IMP)
smooth muscle cell proliferation  (IDA,IMP,ISO)
stress-activated MAPK cascade  (ISO)
uterine smooth muscle contraction  (ISO)
vasoconstriction  (ISO)
vasodilation  (ISO)

Cellular Component
cytoplasm  (ISO)
extracellular space  (IBA,IDA,ISO)
mitochondrion  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal blood homeostasis  (IAGP)
abnormal blood-brain barrier function  (IAGP)
abnormal enzyme/coenzyme level  (IAGP)
abnormal hippocampus granule cell layer  (IAGP)
abnormal juxtaglomerular apparatus morphology  (IAGP)
abnormal kidney afferent arteriole morphology  (IAGP)
abnormal kidney blood vessel morphology  (IAGP)
abnormal kidney cortex artery morphology  (IAGP)
abnormal kidney cortex morphology  (IAGP)
abnormal kidney inner medulla morphology  (IAGP)
abnormal kidney interlobular artery morphology  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal postnatal growth/weight/body size  (IAGP)
abnormal renal filtration rate  (IAGP)
abnormal renal glomerulus morphology  (IAGP)
abnormal renal/urinary system physiology  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased circulating aldosterone level  (IAGP)
decreased circulating angiotensinogen level  (IAGP)
decreased creatinine clearance  (IAGP)
decreased epididymal fat pad weight  (IAGP)
decreased fat cell size  (IAGP)
decreased heart weight  (IAGP)
decreased liver weight  (IAGP)
decreased ovulation rate  (IAGP)
decreased renal glomerulus number  (IAGP)
decreased systemic arterial blood pressure  (IAGP)
decreased systemic arterial diastolic blood pressure  (IAGP)
decreased systemic arterial systolic blood pressure  (IAGP)
decreased total body fat amount  (IAGP)
decreased urine aldosterone level  (IAGP)
decreased urine osmolality  (IAGP)
decreased urine potassium level  (IAGP)
decreased urine sodium level  (IAGP)
dilated kidney collecting duct  (IAGP)
dilated renal tubules  (IAGP)
expanded mesangial matrix  (IAGP)
hydronephrosis  (IAGP)
hyperactivity  (IAGP)
hypertension  (IAGP)
hypotension  (IAGP)
increased circulating angiotensinogen level  (IAGP)
increased circulating antidiuretic hormone level  (IAGP)
increased circulating creatinine level  (IAGP)
increased circulating renin level  (IAGP)
increased fluid intake  (IAGP)
increased kidney weight  (IAGP)
increased renal plasma flow rate  (IAGP)
increased systemic arterial blood pressure  (IAGP)
increased urine antidiuretic hormone level  (IAGP)
increased urine flow rate  (IAGP)
kidney atrophy  (IAGP)
kidney cortex atrophy  (IAGP)
kidney medulla atrophy  (IAGP)
kidney papillary atrophy  (IAGP)
kidney papillary hypoplasia  (IAGP)
polydipsia  (IAGP)
polyuria  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
renal interstitial fibrosis  (IAGP)
renal tubule atrophy  (IAGP)
slow postnatal weight gain  (IAGP)
tubulointerstitial nephritis  (IAGP)
vascular smooth muscle hyperplasia  (IAGP)
References

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Additional References at PubMed
PMID:1628813   PMID:2175614   PMID:2563581   PMID:2573515   PMID:2792385   PMID:3397061   PMID:7708716   PMID:8093670   PMID:8170956   PMID:8228167   PMID:8675666   PMID:8889548  
PMID:8952516   PMID:9039002   PMID:9077534   PMID:9196031   PMID:9310306   PMID:9316207   PMID:9507198   PMID:9507206   PMID:9557921   PMID:9612331   PMID:9734405   PMID:9788961  
PMID:9837754   PMID:9837769   PMID:9852267   PMID:9876285   PMID:9878677   PMID:9884332   PMID:9889347   PMID:9931123   PMID:9973259   PMID:10076178   PMID:10081975   PMID:10205143  
PMID:10318840   PMID:10349636   PMID:10358057   PMID:10405217   PMID:10425188   PMID:10585456   PMID:10603124   PMID:10604517   PMID:10615411   PMID:10617578   PMID:10625648   PMID:10642587  
PMID:10720939   PMID:10775573   PMID:10922068   PMID:11015607   PMID:11042159   PMID:11076861   PMID:11096065   PMID:11124149   PMID:11133514   PMID:11217851   PMID:11292619   PMID:11384650  
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PMID:30944205   PMID:31604805   PMID:32186897   PMID:32640904  


Genomics

Comparative Map Data
Agt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398125,283,326 - 125,296,445 (-)NCBIGRCm39mm39
GRCm39 Ensembl8125,283,273 - 125,296,445 (-)Ensembl
GRCm388124,556,587 - 124,569,706 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8124,556,534 - 124,569,706 (-)EnsemblGRCm38mm10GRCm38
MGSCv378127,080,487 - 127,093,607 (-)NCBIGRCm37mm9NCBIm37
MGSCv368127,442,677 - 127,455,773 (-)NCBImm8
Celera8128,860,995 - 128,873,954 (-)NCBICelera
Cytogenetic Map8E2NCBI
cM Map872.81NCBI
AGT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1230,702,523 - 230,714,122 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1230,690,776 - 230,745,576 (-)EnsemblGRCh38hg38GRCh38
GRCh381230,702,523 - 230,745,583 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371230,838,269 - 230,881,329 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361228,904,892 - 228,916,564 (-)NCBINCBI36hg18NCBI36
Build 341227,145,019 - 227,156,602NCBI
Celera1204,104,291 - 204,116,358 (-)NCBI
Cytogenetic Map1q42.2NCBI
HuRef1201,323,209 - 201,335,277 (-)NCBIHuRef
CHM1_11232,111,282 - 232,123,349 (-)NCBICHM1_1
Agt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21952,529,139 - 52,549,618 (-)NCBI
Rnor_6.0 Ensembl1957,321,640 - 57,333,433 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01957,321,594 - 57,333,460 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01968,026,182 - 68,038,550 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41954,738,556 - 54,750,349 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11954,743,436 - 54,755,230 (-)NCBI
Celera1951,899,180 - 51,910,819 (-)NCBICelera
Cytogenetic Map19q12NCBI
Agt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554927,866,833 - 7,873,357 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554927,863,662 - 7,874,863 (+)NCBIChiLan1.0ChiLan1.0
AGT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11211,279,015 - 211,291,044 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1211,279,015 - 211,291,044 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01206,252,141 - 206,263,830 (-)NCBIMhudiblu_PPA_v0panPan3
AGT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.148,681,192 - 8,694,059 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl48,683,798 - 8,693,880 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha48,672,874 - 8,685,743 (+)NCBI
ROS_Cfam_1.048,705,485 - 8,718,357 (+)NCBI
UMICH_Zoey_3.148,709,653 - 8,722,523 (+)NCBI
UNSW_CanFamBas_1.048,831,567 - 8,844,457 (+)NCBI
UU_Cfam_GSD_1.049,061,768 - 9,074,658 (+)NCBI
Agt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934443,547,972 - 43,555,916 (+)NCBI
SpeTri2.0NW_00493648419,713,299 - 19,721,144 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AGT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1459,643,292 - 59,672,428 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11459,643,030 - 59,656,835 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21464,380,799 - 64,385,995 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AGT
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12567,964,840 - 67,977,006 (-)NCBI
ChlSab1.1 Ensembl2567,962,401 - 67,973,324 (-)Ensembl
Agt
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477518,846,222 - 18,856,093 (+)NCBI

Position Markers
AI265500  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm388124,556,855 - 124,556,971UniSTSGRCm38
MGSCv378127,080,755 - 127,080,871UniSTSGRCm37
Celera8128,861,266 - 128,861,382UniSTS
Cytogenetic Map8E2UniSTS
cM Map868.0UniSTS
Whitehead/MRC_RH81446.17UniSTS
PMC162290P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm388124,564,252 - 124,564,531UniSTSGRCm38
MGSCv378127,088,152 - 127,088,431UniSTSGRCm37
Celera8128,868,494 - 128,868,773UniSTS
Cytogenetic Map8E2UniSTS
cM Map868.0UniSTS
Agt  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv378127,080,514 - 127,080,663UniSTSGRCm37
Celera8128,861,022 - 128,861,174UniSTS
Cytogenetic Map8E2UniSTS
cM Map868.0UniSTS
cM Map868.0UniSTS
RH65641  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm388124,557,546 - 124,558,418UniSTSGRCm38
MGSCv378127,081,446 - 127,082,318UniSTSGRCm37
Celera8128,861,958 - 128,862,831UniSTS
Cytogenetic Map8E2UniSTS
cM Map868.0UniSTS
Agt  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm388124,556,614 - 124,556,763UniSTSGRCm38
MGSCv378127,080,514 - 127,080,663UniSTSGRCm37
Celera8128,861,022 - 128,861,174UniSTS
Cytogenetic Map8E2UniSTS
cM Map868.0UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)873400000126100000Mouse
27226796Scvln16_msacral vertebrae length 2, 16 week (mouse)889000000130800000Mouse
1357494Obsty2_mobesity 2 (mouse)Not determined895518613129018580Mouse
12880431Fgf23lq2_mFGF23 serum level QTL 2 (mouse)896900000129401213Mouse
11252141Fdr2_mfat response to dietary restriction 2 (mouse)897663894129401213Mouse
1301481Lith11_mlithogenic gene 11 (mouse)Not determined897836895129401213Mouse
1301080Sluc9_msusceptibility to lung cancer 9 (mouse)Not determined899101792129401213Mouse
1302105Im1_mImmunoregulatory 1 (mouse)Not determined899101792129401213Mouse
4141435Fbtq3_mfemoral bone trait QTL 3 (mouse)Not determined8100238570129401213Mouse
1301316Dntcs1_mdental caries susceptibility 1 (mouse)Not determined8102716921127055036Mouse
11532691Sluc38_msusceptibility to lung cancer 38 (mouse)8104307238129401213Mouse
11532692Sluc38a_msusceptibility to lung cancer 38a (mouse)8104307238129401213Mouse
14746994Manh65_mmandible shape 65 (mouse)8105762890129401213Mouse
10412273Fcd1_mfunctional capillary density 1 (mouse)Not determined8109688333129401213Mouse
10412274Leci1_mleukocyte endothelial cell interactions 1 (mouse)Not determined8109688333129401213Mouse
12904938Edlmmq7_mextensor digitorum longus muscle mass QTL 7 (mouse)8110755016129401213Mouse
12904960Gmmq6_mgastrocnemius muscle mass QTL 6 (mouse)8110755016129401213Mouse
4141546Mrdq3_mmodifier of retinal degeneration QTL 3 (mouse)Not determined113712788125329141Mouse
26884375Skwq2_mskull length QTL 2, 5 week (mouse)8120000000131200000Mouse
1357841Phdlc2_mplasma HDL cholesterol 2 (mouse)Not determined8124464422129018580Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:147
Count of miRNA genes:126
Interacting mature miRNAs:138
Transcripts:ENSMUST00000063278
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence