Agt (angiotensinogen (serpin peptidase inhibitor, clade A, member 8)) - Rat Genome Database

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Gene: Agt (angiotensinogen (serpin peptidase inhibitor, clade A, member 8)) Mus musculus
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Symbol: Agt
Name: angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
RGD ID: 10118
MGI Page MGI
Description: Enables type 1 angiotensin receptor binding activity and type 2 angiotensin receptor binding activity. Involved in aldosterone secretion and positive regulation of cytokine production. Acts upstream of or within several processes, including nervous system development; positive regulation of protein phosphorylation; and regulation of systemic arterial blood pressure by renin-angiotensin. Located in extracellular space. Is expressed in several structures, including axial skeleton; central nervous system; foregut mesenchyme; genitourinary system; and liver. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Henoch-Schoenlein purpura; artery disease (multiple); heart conduction disease (multiple); and hydronephrosis. Orthologous to human AGT (angiotensinogen).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI265500; AngI; AngII; angiotensin I; angiotensin ll; angiotensinogen; Ao; Aogen; Se; serpin A8; Serpina8
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398125,283,326 - 125,296,445 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8125,283,273 - 125,296,445 (-)EnsemblGRCm39 Ensembl
GRCm388124,556,587 - 124,569,706 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8124,556,534 - 124,569,706 (-)EnsemblGRCm38mm10GRCm38
MGSCv378127,080,487 - 127,093,607 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368127,442,677 - 127,455,773 (-)NCBIMGSCv36mm8
Celera8128,860,995 - 128,873,954 (-)NCBICelera
Cytogenetic Map8E2NCBI
cM Map872.81NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Albuminuria  (ISO)
alcoholic cardiomyopathy  (ISO)
alcoholic hepatitis  (ISO)
Alkalosis  (ISO)
allergic disease  (ISO)
Alzheimer's disease  (ISO)
Anaphylaxis  (ISO)
anemia  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
anuria  (ISO)
aortic aneurysm  (ISO)
Aortic Calcification  (ISO)
Aortic Coarctation  (ISO)
atherosclerosis  (ISO)
atrial fibrillation  (ISO)
bipolar disorder  (ISO)
Bradycardia  (ISO)
breast cancer  (ISO)
Cardiac Arrhythmias  (ISO)
Cardiomegaly  (IDA,IEP,ISO)
cardiomyopathy  (ISO)
Cardiotoxicity  (ISO)
Cardiovascular Abnormalities  (ISO)
cardiovascular system disease  (ISO)
carotid artery disease  (ISO)
Catalepsy  (ISO)
cerebrovascular disease  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholestasis  (ISO)
Chronic Intermittent Hypoxia  (ISO)
chronic myeloid leukemia  (ISO)
cleidocranial dysplasia  (ISO)
cognitive disorder  (ISO)
congestive heart failure  (ISO)
corneal neovascularization  (IEP)
coronary artery disease  (ISO)
COVID-19  (ISO)
Crohn's disease  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (IMP,ISO)
Diaphragmatic Hernia  (ISO)
diffuse scleroderma  (ISO)
dilated cardiomyopathy  (ISO)
Dissecting Aneurysm  (ISO)
Drug Overdose  (ISO)
end stage renal disease  (ISO)
endomyocardial fibrosis  (ISO)
essential hypertension  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Mammary Neoplasms  (IDA)
Fabry disease  (ISO)
Fetal Growth Retardation  (ISO)
Fibrosis  (ISO)
focal segmental glomerulosclerosis  (ISO)
gastric ulcer  (ISO)
gastrointestinal stromal tumor  (ISO)
glomerulonephritis  (ISO)
glucose intolerance  (ISO)
heart disease  (ISO)
Hemorrhage  (ISO)
Henoch-Schoenlein purpura  (ISO)
hydronephrosis  (IMP,ISO)
Hyperalgesia  (ISO)
Hyperemia  (ISO)
hyperhomocysteinemia  (ISO)
hyperinsulinism  (ISO)
hypertension  (IDA,ISO)
Hypertensive Nephropathy  (ISO)
hypertrophic cardiomyopathy  (ISO)
Hypertrophy  (ISO)
hypokalemia  (ISO)
Hypotension  (IMP,ISO)
IgA glomerulonephritis  (ISO)
impotence  (ISO)
Inflammation  (ISO)
inflammatory bowel disease  (ISO)
intermediate coronary syndrome  (ISO)
Intestinal Reperfusion Injury  (ISO)
kidney disease  (ISO)
kidney failure  (ISO)
Left Ventricular Hypertrophy  (ISO)
liver cirrhosis  (ISO)
malignant hypertension  (ISO)
meconium aspiration syndrome  (ISO)
Metabolic Syndrome  (ISO)
microcephaly  (ISO)
middle cerebral artery infarction  (ISO)
mitral valve prolapse  (ISO)
multiple sclerosis  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
Necrosis  (ISO)
Neointima  (ISO)
nephrosis  (ISO)
Neurobehavioral Manifestations  (ISO)
obesity  (ISO)
oligohydramnios  (ISO)
otosclerosis  (ISO)
parathyroid carcinoma  (ISO)
Peptic Ulcer Hemorrhage  (ISO)
pneumonia  (ISO)
polycystic kidney disease  (ISO)
pre-eclampsia  (ISO)
prediabetes syndrome  (ISO)
Pregnancy-Induced Hypertension  (ISO)
primary biliary cholangitis  (ISO)
proteinuria  (ISO)
pulmonary edema  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
Puromycin Aminonucleoside Nephrosis  (ISO)
renal hypertension  (ISO)
Renal Tubular Dysgenesis  (ISO)
Reperfusion Injury  (ISO)
retinal vasculitis  (IDA)
retinopathy of prematurity  (ISO)
sciatic neuropathy  (ISO)
sick sinus syndrome  (ISO)
skin melanoma  (ISO)
Stroke  (ISO)
Sudden Death  (ISO)
systemic scleroderma  (ISO)
temporal lobe epilepsy  (ISO)
thrombosis  (ISO)
transient cerebral ischemia  (ISO)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (ISO)
vascular disease  (ISO)
Vascular Malformations  (ISO)
Vascular Remodeling  (ISO)
Ventricular Dysfunction, Left  (ISO)
Ventricular Remodeling  (ISO)
visual epilepsy  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-taxifolin  (EXP)
(R)-lipoic acid  (EXP)
(R)-mevalonic acid  (ISO)
(R)-noradrenaline  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-amphetamine  (EXP)
1,2-dichloroethane  (EXP)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (ISO)
11-deoxycorticosterone  (ISO)
11-Hydroxyandrostenedione  (ISO)
14,15-EET  (EXP,ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2,6-dinitrotoluene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
3',5'-cyclic GMP  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (ISO)
3,7-dihydropurine-6-thione  (ISO)
3-[3-acetyl-4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl]-1,1-diethylurea  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-Hydroperoxy-2-nonenal  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
4-hydroxy-TEMPO  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
4-phenylbutyric acid  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-oxoprostaglandin F1alpha  (ISO)
6-propyl-2-thiouracil  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP,ISO)
8-Br-cAMP  (ISO)
8-hydroxy-2'-deoxyguanosine  (ISO)
AACOCF3  (ISO)
Ac-Ser-Asp-Lys-Pro-OH  (EXP,ISO)
acadesine  (ISO)
acetamide  (ISO)
acetylcholine  (EXP)
acetylsalicylic acid  (ISO)
actinomycin D  (ISO)
adefovir  (ISO)
Adenosine, cyclic 3',5'-[hydrogen [p(s)]-phosphorothioate]  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (ISO)
aldosterone  (EXP,ISO)
aliskiren  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
allopurinol  (ISO)
alpha-cyano-4-hydroxycinnamic acid  (ISO)
amidotrizoic acid  (ISO)
amiloride  (ISO)
amiodarone  (ISO)
amitrole  (ISO)
amlodipine  (ISO)
ammonia  (EXP)
ammonium chloride  (ISO)
angiotensin II  (EXP,ISO)
ANTIMYCIN  (ISO)
apocynin  (EXP,ISO)
arachidonic acid  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
aspartame  (ISO)
astressin  (ISO)
atenolol  (ISO)
atorvastatin calcium  (ISO)
azoxystrobin  (ISO)
bafilomycin A1  (ISO)
BAPTA  (EXP)
benazepril  (ISO)
benidipine  (ISO)
benzbromarone  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-D-glucosamine  (EXP)
beta-endorphin  (ISO)
biopterin  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol F  (EXP)
boric acid  (EXP)
BQ 123  (EXP,ISO)
brefeldin A  (ISO)
brimonidine tartrate  (ISO)
Brodifacoum  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
caffeine  (ISO)
calciol  (EXP)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
candesartan  (EXP,ISO)
Candesartan cilexetil  (ISO)
captopril  (EXP,ISO)
carbon monoxide  (EXP)
carbon nanotube  (EXP)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
carmustine  (ISO)
carvedilol  (ISO)
CCCP  (ISO)
CGP-42112A  (EXP)
chlorpyrifos  (EXP,ISO)
cholesterol  (EXP,ISO)
chromium atom  (ISO)
chymostatin  (EXP,ISO)
ciglitazone  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP,ISO)
clofibric acid  (ISO)
clozapine  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
corticosterone  (ISO)
cortisol  (ISO)
Cuprizon  (ISO)
curcumin  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cypermethrin  (ISO)
D-glucose  (ISO)
DDE  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
dibenziodolium  (EXP,ISO)
diethyl malate  (EXP)
diminazene diaceturate  (EXP,ISO)
dioxygen  (EXP,ISO)
disodium cromoglycate  (ISO)
diuron  (ISO)
dopamine  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (ISO)
doxycycline  (ISO)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (ISO)
efonidipine hydrochloride  (ISO)
elcometrine  (ISO)
emodin  (ISO)
enalapril  (EXP,ISO)
enalaprilat dihydrate  (ISO)
endosulfan  (ISO)
eplerenone  (EXP)
ergosta-4,6,8(14),22-tetraen-3-one  (EXP,ISO)
ethanol  (EXP,ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
famotidine  (ISO)
fenofibrate  (EXP)
flavonoids  (ISO)
flutamide  (ISO)
folic acid  (EXP,ISO)
fosinopril  (ISO)
fructose  (EXP,ISO)
fulvestrant  (ISO)
fumonisin B1  (EXP,ISO)
furan  (ISO)
furosemide  (ISO)
genistein  (ISO)
gentamycin  (ISO)
Ginkgoic acid  (EXP)
glucose  (ISO)
glutathione  (EXP,ISO)
glutathione disulfide  (EXP)
glycerol  (ISO)
glycochenodeoxycholic acid  (ISO)
glyphosate  (ISO)
goralatide  (EXP,ISO)
heparin  (ISO)
hydralazine  (EXP,ISO)
hydrazines  (EXP)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
ibuprofen  (ISO)
ICI 118551  (EXP)
Ile(5)-angiotensin II  (EXP,ISO)
imidacloprid  (ISO)
imidaprilat  (EXP)
imperatorin  (ISO)
indometacin  (ISO)
iohexol  (ISO)
irbesartan  (EXP,ISO)
irinotecan  (ISO)
isoprenaline  (EXP,ISO)
isorhamnetin  (ISO)
Isorhapontigenin  (ISO)
ketamine  (ISO)
L-ascorbic acid  (ISO)
L-ethionine  (ISO)
labetalol  (ISO)
lactacystin  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
levonorgestrel  (ISO)
linoleic acid hydroperoxide  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
lipoxin A4  (EXP)
lisinopril dihydrate  (EXP,ISO)
losartan  (EXP,ISO)
LY294002  (ISO)
Magnolol  (ISO)
malonaldehyde  (EXP,ISO)
mangiferin  (ISO)
melatonin  (ISO)
mercaptopurine  (ISO)
mercury dichloride  (ISO)
metformin  (EXP)
methamphetamine  (ISO)
methimazole  (ISO)
methotrexate  (EXP,ISO)
methylglyoxal  (ISO)
Mibefradil  (ISO)
microcystin RR  (EXP)
midostaurin  (ISO)
miquelianin  (ISO)
mithramycin  (ISO)
MK-2206  (ISO)
monocrotaline  (ISO)
montelukast  (ISO)
mycophenolic acid  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-desethylamiodarone  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-methylnicotinate  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
naloxone  (ISO)
naringin  (ISO)
nebivolol  (ISO)
Neferine  (ISO)
nerolidol  (ISO)
nickel atom  (ISO)
nicorandil  (EXP)
nicotinic acid  (EXP,ISO)
nimesulide  (EXP)
nitric oxide  (EXP,ISO)
nitrites  (ISO)
nitrofen  (ISO)
nitrofurantoin  (ISO)
nitroprusside  (EXP)
NS-398  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
okadaic acid  (EXP)
olmesartan  (ISO)
oltipraz  (EXP,ISO)
omeprazole  (ISO)
ouabain  (ISO)
ozone  (ISO)
Pachymic acid  (EXP,ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (EXP)
PD 168393  (ISO)
PD123319  (EXP,ISO)
perfluorooctanoic acid  (ISO)
perindopril  (ISO)
peroxynitrous acid  (EXP)
phenylarsine oxide  (ISO)
phenylephrine  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
phosphatidic acid  (ISO)
phosphoramidon  (ISO)
pindolol  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
potassium atom  (ISO)
potassium dichromate  (EXP)
pravastatin  (EXP,ISO)
pregabalin  (ISO)
probenecid  (ISO)
progesterone  (EXP,ISO)
propanal  (ISO)
propranolol  (EXP,ISO)
prostaglandin E1  (ISO)
prostaglandin E2  (ISO)
prostaglandin I2  (ISO)
prostaglandins E  (ISO)
purine-6-thiol  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP,ISO)
quinacrine  (EXP)
quinapril hydrochloride  (ISO)
raloxifene  (ISO)
reactive oxygen species  (EXP,ISO)
reboxetine  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP,ISO)
rottlerin  (ISO)
rutin  (ISO)
salubrinal  (ISO)
saralasin  (ISO)
SB 203580  (EXP,ISO)
scopolamine  (ISO)
sevoflurane  (EXP)
sildenafil citrate  (EXP,ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium atom  (ISO)
sodium chloride  (ISO)
Soman  (ISO)
spironolactone  (ISO)
streptozocin  (EXP,ISO)
succimer  (ISO)
sucrose  (ISO)
sulforaphane  (EXP)
sunitinib  (ISO)
superoxide  (EXP,ISO)
tamibarotene  (EXP)
tamoxifen  (ISO)
taurine  (ISO)
taurolithocholic acid sulfate  (ISO)
tauroursodeoxycholic acid  (ISO)
telmisartan  (EXP,ISO)
temozolomide  (ISO)
testosterone  (ISO)
Testosterone propionate  (ISO)
tetrachloromethane  (ISO)
tetracycline  (EXP)
thiabendazole  (ISO)
thioacetamide  (ISO)
thiopental  (ISO)
Thiorphan  (EXP,ISO)
Tiron  (EXP,ISO)
titanium dioxide  (EXP,ISO)
torasemide  (ISO)
trandolapril  (EXP,ISO)
trans-piceid  (ISO)
tributylstannane  (EXP,ISO)
trichloroethene  (ISO)
triclosan  (ISO)
troglitazone  (ISO)
tyrphostin AG 1478  (ISO)
U-73122  (ISO)
valproic acid  (EXP,ISO)
valsartan  (EXP,ISO)
Vinpocetine  (ISO)
vismodegib  (ISO)
wortmannin  (ISO)
xestospongin C  (ISO)
zaragozic acid A  (EXP,ISO)
zinc atom  (ISO)
zinc protoporphyrin  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of NF-kappaB-inducing kinase activity  (IDA)
activation of phospholipase C activity  (ISO)
aging  (ISO)
aldosterone secretion  (IMP)
angiotensin-activated signaling pathway  (ISO)
angiotensin-mediated drinking behavior  (ISO)
angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure  (IDA)
artery smooth muscle contraction  (ISO)
associative learning  (ISO)
astrocyte activation  (IMP)
blood vessel development  (IMP)
brain renin-angiotensin system  (IDA)
branching involved in ureteric bud morphogenesis  (IDA,IMP)
cell growth involved in cardiac muscle cell development  (ISO)
cell population proliferation  (IMP)
cell surface receptor signaling pathway  (ISO)
cell-matrix adhesion  (IMP)
cellular response to angiotensin  (ISO)
cellular response to mechanical stimulus  (ISO)
cytokine production  (ISO)
drinking behavior  (IMP)
ERK1 and ERK2 cascade  (ISO)
establishment of blood-nerve barrier  (IMP)
extracellular matrix organization  (IMP)
female pregnancy  (ISO)
fibroblast proliferation  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
hormone metabolic process  (IMP)
intracellular sodium ion homeostasis  (ISO)
kidney development  (IMP,ISO)
MAPK cascade  (IMP)
negative regulation of angiogenesis  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of cell population proliferation  (IMP)
negative regulation of gene expression  (ISO)
negative regulation of MAP kinase activity  (ISO)
negative regulation of neuron apoptotic process  (IMP)
negative regulation of neurotrophin TRK receptor signaling pathway  (ISO)
negative regulation of smooth muscle cell proliferation  (IMP)
negative regulation of tissue remodeling  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (IMP)
neuron apoptotic process  (IMP)
obsolete positive regulation of cholesterol esterification  (ISO)
operant conditioning  (ISO)
organ growth  (IDA)
ovarian follicle rupture  (IMP)
peristalsis  (IMP)
positive regulation of activation of Janus kinase activity  (ISO)
positive regulation of blood pressure  (ISO)
positive regulation of branching involved in ureteric bud morphogenesis  (ISO)
positive regulation of cardiac muscle cell apoptotic process  (ISO)
positive regulation of cardiac muscle hypertrophy  (ISO)
positive regulation of catalytic activity  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of CoA-transferase activity  (ISO)
positive regulation of cytokine production  (IMP)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of endothelial cell migration  (ISO)
positive regulation of epidermal growth factor receptor signaling pathway  (ISO)
positive regulation of extracellular matrix constituent secretion  (ISO)
positive regulation of extrinsic apoptotic signaling pathway  (ISO)
positive regulation of fatty acid biosynthetic process  (IMP)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of gap junction assembly  (ISO)
positive regulation of gene expression  (IDA)
positive regulation of insulin receptor signaling pathway  (ISO)
positive regulation of L-arginine import across plasma membrane  (ISO)
positive regulation of L-lysine import across plasma membrane  (ISO)
positive regulation of macrophage derived foam cell differentiation  (ISO)
positive regulation of MAPK cascade  (IMP)
positive regulation of membrane hyperpolarization  (ISO)
positive regulation of multicellular organism growth  (IMP)
positive regulation of neuron projection development  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of organ growth  (IDA,IMP)
positive regulation of peptidyl-serine phosphorylation  (IDA)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase signaling  (ISO)
positive regulation of protein kinase C activity  (IDA)
positive regulation of protein metabolic process  (ISO)
positive regulation of protein tyrosine kinase activity  (ISO)
positive regulation of renal sodium excretion  (ISO)
positive regulation of superoxide anion generation  (ISO)
positive regulation of vascular associated smooth muscle cell migration  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
protein import into nucleus  (ISO)
regulation of apoptotic process  (IBA,IDA,ISO)
regulation of blood pressure  (IMP,ISO)
regulation of calcium ion transport  (ISO)
regulation of cardiac conduction  (ISO)
regulation of extracellular matrix assembly  (ISO)
regulation of gene expression  (IDA)
regulation of heart rate  (ISO)
regulation of inflammatory response  (IDA,IGI)
regulation of long-term neuronal synaptic plasticity  (ISO)
regulation of norepinephrine secretion  (ISO)
regulation of renal output by angiotensin  (IMP)
regulation of renal sodium excretion  (ISO)
regulation of systemic arterial blood pressure by circulatory renin-angiotensin  (IMP)
regulation of transmission of nerve impulse  (ISO)
renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure  (IMP)
renal system process  (ISO)
renin-angiotensin regulation of aldosterone production  (IMP,ISO)
response to cold  (IMP)
response to estradiol  (ISO)
response to muscle activity involved in regulation of muscle adaptation  (ISO)
response to salt stress  (IMP)
smooth muscle cell differentiation  (IDA,IMP)
smooth muscle cell proliferation  (IDA,IMP,ISO)
stress-activated MAPK cascade  (ISO)
uterine smooth muscle contraction  (ISO)
vascular associated smooth muscle cell proliferation  (IMP)
vasoconstriction  (ISO)
vasodilation  (ISO)
vasopressin secretion  (IMP)

Cellular Component
cytoplasm  (ISO)
extracellular space  (IBA,IDA,ISO)
mitochondrion  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal blood homeostasis  (IAGP)
abnormal enzyme/coenzyme level  (IAGP)
abnormal hippocampus granule cell layer  (IAGP)
abnormal juxtaglomerular apparatus morphology  (IAGP)
abnormal kidney afferent arteriole morphology  (IAGP)
abnormal kidney blood vessel morphology  (IAGP)
abnormal kidney cortex artery morphology  (IAGP)
abnormal kidney cortex morphology  (IAGP)
abnormal kidney inner medulla morphology  (IAGP)
abnormal kidney interlobular artery morphology  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal postnatal growth/weight/body size  (IAGP)
abnormal renal filtration rate  (IAGP)
abnormal renal glomerulus morphology  (IAGP)
abnormal renal/urinary system physiology  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased circulating aldosterone level  (IAGP)
decreased circulating angiotensinogen level  (IAGP)
decreased creatinine clearance  (IAGP)
decreased epididymal fat pad weight  (IAGP)
decreased fat cell size  (IAGP)
decreased heart weight  (IAGP)
decreased liver weight  (IAGP)
decreased renal glomerulus number  (IAGP)
decreased superovulation rate  (IAGP)
decreased systemic arterial blood pressure  (IAGP)
decreased systemic arterial diastolic blood pressure  (IAGP)
decreased systemic arterial systolic blood pressure  (IAGP)
decreased total body fat amount  (IAGP)
decreased urine aldosterone level  (IAGP)
decreased urine osmolality  (IAGP)
decreased urine potassium level  (IAGP)
decreased urine sodium level  (IAGP)
dilated kidney collecting duct  (IAGP)
dilated renal tubule  (IAGP)
expanded mesangial matrix  (IAGP)
hydronephrosis  (IAGP)
hypertension  (IAGP)
hypotension  (IAGP)
impaired blood-brain barrier function  (IAGP)
increased circulating angiotensinogen level  (IAGP)
increased circulating antidiuretic hormone level  (IAGP)
increased circulating creatinine level  (IAGP)
increased circulating renin level  (IAGP)
increased fluid intake  (IAGP)
increased kidney weight  (IAGP)
increased locomotor activity  (IAGP)
increased renal plasma flow rate  (IAGP)
increased systemic arterial blood pressure  (IAGP)
increased urine antidiuretic hormone level  (IAGP)
increased urine flow rate  (IAGP)
kidney atrophy  (IAGP)
kidney cortex atrophy  (IAGP)
kidney medulla atrophy  (IAGP)
kidney papillary atrophy  (IAGP)
kidney papillary hypoplasia  (IAGP)
polydipsia  (IAGP)
polyuria  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
renal interstitial fibrosis  (IAGP)
renal tubule atrophy  (IAGP)
slow postnatal weight gain  (IAGP)
tubulointerstitial nephritis  (IAGP)
vascular smooth muscle hyperplasia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Attenuation of angiotensin II-induced hypertension and cardiac hypertrophy in transgenic mice overexpressing a type 1 receptor mutant. Ahmad S, etal., Am J Hypertens. 2009 Dec;22(12):1320-5. doi: 10.1038/ajh.2009.181. Epub 2009 Sep 24.
2. Metabolic syndrome biomarkers and early breast cancer in Saudi women: evidence for the presence of a systemic stress response and/or a pre-existing metabolic syndrome-related neoplasia risk? Alokail MS, etal., BMC Cancer. 2013 Feb 4;13:54. doi: 10.1186/1471-2407-13-54.
3. Angiotensinogen promoter and angiotensinogen II receptor type 1 gene polymorphisms and incidence of ischemic stroke and neurologic phenotype in Fabry disease. Altarescu G, etal., Biomarkers. 2013 Nov;18(7):595-600. doi: 10.3109/1354750X.2013.836244. Epub 2013 Sep 10.
4. Candesartan cilexetil protects from cardiac myosin induced cardiotoxicity via reduction of endoplasmic reticulum stress and apoptosis in rats: involvement of ACE2-Ang (1-7)-mas axis. Arumugam S, etal., Toxicology. 2012 Jan 27;291(1-3):139-45. doi: 10.1016/j.tox.2011.11.008. Epub 2011 Nov 23.
5. Lack of association between angiotensinogen polymorphism (M235T) and cerebrovascular disease and carotid atheroma. Barley J, etal., J Hum Hypertens. 1995 Aug;9(8):681-3.
6. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
7. Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Brady KP, etal., Genome Res 1997 Nov;7(11):1085-93.
8. The renin-angiotensin and the kallikrein-kinin systems. Campbell DJ Int J Biochem Cell Biol. 2003 Jun;35(6):784-91.
9. Genetic predisposition to thrombophilia in inflammatory bowel disease. Cappello M, etal., J Clin Gastroenterol. 2011 Mar;45(3):e25-9. doi: 10.1097/MCG.0b013e3181eb6132.
10. Promoter polymorphism G-6A, which modulates angiotensinogen gene expression, is associated with non-familial sick sinus syndrome. Chen JY, etal., PLoS One. 2012;7(1):e29951. doi: 10.1371/journal.pone.0029951. Epub 2012 Jan 5.
11. Ang-(1-7) might prevent the development of monocrotaline induced pulmonary arterial hypertension in rats. Chen L, etal., Eur Rev Med Pharmacol Sci. 2011 Jan;15(1):1-7.
12. Hepatic expression of candidate genes in patients with alcoholic hepatitis: correlation with disease severity. Colmenero J, etal., Gastroenterology. 2007 Feb;132(2):687-97. Epub 2006 Dec 20.
13. Angiotensin-(1-7) reduces fibrosis in orthotopic breast tumors. Cook KL, etal., Cancer Res. 2010 Nov 1;70(21):8319-28. Epub 2010 Sep 13.
14. The angiotensin II type 2 receptor causes constitutive growth of cardiomyocytes and does not antagonize angiotensin II type 1 receptor-mediated hypertrophy. D'Amore A, etal., Hypertension. 2005 Dec;46(6):1347-54. Epub 2005 Nov 14.
15. Evidence that the vasodilator angiotensin-(1-7)-Mas axis plays an important role in erectile function. da Costa Goncalves AC, etal., Am J Physiol Heart Circ Physiol. 2007 Oct;293(4):H2588-96. Epub 2007 Jul 6.
16. Renin-angiotensin system gene polymorphisms in children with Henoch-Schonlein purpura in West China. Desong Liu, etal., J Renin Angiotensin Aldosterone Syst. 2010 Dec;11(4):248-55. doi: 10.1177/1470320310374214. Epub 2010 Aug 11.
17. Aberrant activation of the intrarenal renin-angiotensin system in the developing kidneys of type 2 diabetic rats. Fan YY, etal., Horm Metab Res. 2013 May;45(5):338-43. doi: 10.1055/s-0032-1331256. Epub 2013 Jan 15.
18. AGT and ACE genes influence classic mitral valve prolapse predisposition in Marfan patients. Fatini C, etal., Int J Cardiol. 2008 Jan 24;123(3):293-7. Epub 2007 Mar 26.
19. Thalidomide-induced angiopoietin 2, Notch1 and Dll4 downregulation under hypoxic condition in tissues with gastrointestinal vascular malformation and human umbilical vein endothelial cells. Feng Q, etal., J Dig Dis. 2014 Feb;15(2):85-95. doi: 10.1111/1751-2980.12114.
20. Genetic polymorphisms of the renin-angiotensin system in breast cancer patients. Fishchuk LE and Gorovenko NG, Exp Oncol. 2013 Jun;35(2):101-4.
21. A molecular variant of angiotensinogen is associated with diabetic nephropathy in IDDM. Fogarty DG, etal., Diabetes. 1996 Sep;45(9):1204-8.
22. Relationship between polymorphisms in the renin-angiotensin system and nephropathy in type 2 diabetic patients. Fradin S, etal., Diabetes Metab. 2002 Feb;28(1):27-32.
23. Analysis of renin-angiotensin-aldosterone system gene polymorphisms in resistant hypertension. Freitas SR, etal., Braz J Med Biol Res. 2007 Mar;40(3):309-16.
24. Therapeutic effects of postischemic treatment with hypotensive doses of an angiotensin II receptor blocker on transient focal cerebral ischemia. Fu H, etal., J Hypertens. 2011 Nov;29(11):2210-9. doi: 10.1097/HJH.0b013e32834bbb30.
25. Polymorphisms in thrombophilia and renin-angiotensin system pathways, preterm delivery, and evidence of placental hemorrhage. Gargano JW, etal., Am J Obstet Gynecol. 2009 Sep;201(3):317.e1-9. doi: 10.1016/j.ajog.2009.05.060.
26. Differential roles of Angiotensinogen and Angiotensin Receptor type 1 polymorphisms in breast cancer risk. Gonzalez-Zuloeta Ladd AM, etal., Breast Cancer Res Treat. 2007 Mar;101(3):299-304. Epub 2006 Jul 6.
27. Association Between the M268T Polymorphism in the Angiotensinogen Gene and Essential Hypertension in a South Indian Population. Gopi Chand M, etal., Biochem Genet. 2011 Feb 11.
28. The renin-angiotensin system and hypertension in autosomal recessive polycystic kidney disease. Goto M, etal., Pediatr Nephrol. 2010 Dec;25(12):2449-57. doi: 10.1007/s00467-010-1621-z. Epub 2010 Aug 27.
29. The levels of renin-angiotensin related components are modified in the hippocampus of rats submitted to pilocarpine model of epilepsy. Gouveia TL, etal., Neurochem Int. 2012 Jul;61(1):54-62. doi: 10.1016/j.neuint.2012.04.012. Epub 2012 Apr 20.
30. Serum proteomic profile of cutaneous malignant melanoma and relation to cancer progression: association to tumor derived alpha-N-acetylgalactosaminidase activity. Greco M, etal., Cancer Lett. 2009 Oct 8;283(2):222-9. doi: 10.1016/j.canlet.2009.04.001. Epub 2009 Apr 25.
31. Angiotensin I-converting enzyme and angiotensinogen gene polymorphisms in non-insulin-dependent diabetes mellitus. Lack of relationship with diabetic nephropathy and retinopathy in a Caucasian Mediterranean population. Gutierrez C, etal., Metabolism. 1997 Aug;46(8):976-80.
32. Exercise capacity after coarctation repair relates to the c.46A > G genomic polymorphism of the ss2-adrenoreceptor and the c.704T > C angiotensinogen polymorphism. Hager A, etal., Eur J Prev Cardiol. 2012 Apr;19(2):199-204. doi: 10.1177/1741826711399991. Epub 2011 Feb 25.
33. Upregulation of hepatic angiotensin-converting enzyme 2 (ACE2) and angiotensin-(1-7) levels in experimental biliary fibrosis. Herath CB, etal., J Hepatol. 2007 Sep;47(3):387-95. Epub 2007 Apr 2.
34. Effects of circulating and local uteroplacental angiotensin II in rat pregnancy. Hering L, etal., Hypertension. 2010 Aug;56(2):311-8. doi: 10.1161/HYPERTENSIONAHA.110.150961. Epub 2010 Jun 7.
35. Urinary excretion of angiotensin I, II, arginine vasopressin and oxytocin in patients with anaphylactoid reactions. Hermann K, etal., Clin Exp Allergy. 1992 Sep;22(9):845-53.
36. Increased insulin-stimulated expression of arterial angiotensinogen and angiotensin type 1 receptor in patients with type 2 diabetes mellitus and atheroma. Hodroj W, etal., Arterioscler Thromb Vasc Biol. 2007 Mar;27(3):525-31. Epub 2006 Dec 14.
37. Association of 3 gene polymorphisms with atopic diseases. Holla L, etal., J Allergy Clin Immunol. 1999 Apr;103(4):702-8.
38. A vaccine for hypertension based on peptide AngI-R: a pilot study. Hong F, etal., Int J Cardiol. 2011 Apr 1;148(1):76-84. doi: 10.1016/j.ijcard.2009.10.027. Epub 2009 Nov 24.
39. Pleiotropic AT1 receptor signaling pathways mediating physiological and pathogenic actions of angiotensin II. Hunyady L and Catt KJ, Mol Endocrinol. 2006 May;20(5):953-70. Epub 2005 Sep 1.
40. Attenuation of hypertension-mediated glomerulosclerosis in conjunction with increased angiotensin (1-7). Igase M, etal., Ther Adv Cardiovasc Dis. 2011 Dec;5(6):297-304. doi: 10.1177/1753944711429343. Epub 2011 Nov 16.
41. Relation between renin-angiotensin-aldosterone system and otosclerosis: a genetic association and in vitro study. Imauchi Y, etal., Otol Neurotol. 2008 Apr;29(3):295-301.
42. Angiotensinogen gene polymorphism in Japanese patients with hypertrophic cardiomyopathy. Ishanov A, etal., Am Heart J. 1997 Feb;133(2):184-9.
43. Molecular basis of human hypertension: role of angiotensinogen. Jeunemaitre X, etal., Cell 1992 Oct 2;71(1):169-80.
44. Chronic infusion of enalaprilat into hypothalamic paraventricular nucleus attenuates angiotensin II-induced hypertension and cardiac hypertrophy by restoring neurotransmitters and cytokines. Kang YM, etal., Toxicol Appl Pharmacol. 2014 Feb 1;274(3):436-44. doi: 10.1016/j.taap.2013.12.001. Epub 2013 Dec 14.
45. Application of angiotensin II to healthy rat sciatic nerve can produce neuropathy without associated vasculopathy. Kasselman LJ and Rutkove SB, Muscle Nerve. 2010 Dec;42(6):959-65. doi: 10.1002/mus.21767. Epub 2010 Sep 30.
46. Angiotensin II in the lesional skin of systemic sclerosis patients contributes to tissue fibrosis via angiotensin II type 1 receptors. Kawaguchi Y, etal., Arthritis Rheum. 2004 Jan;50(1):216-26.
47. The neuronal isoform of constitutive nitric oxide synthase is up-regulated in the macula densa of angiotensinogen gene-knockout mice. Kihara M, etal., Lab Invest. 1997 Feb;76(2):285-94.
48. Role of intra-renal angiotensin system activation, oxidative stress, inflammation and impaired Nrf2 activity in the progression of focal glomerulosclerosis. Kim HJ, etal., J Pharmacol Exp Ther. 2011 Feb 25.
49. Enhanced intrarenal angiotensinogen contributes to early renal injury in spontaneously hypertensive rats. Kobori H, etal., J Am Soc Nephrol. 2005 Jul;16(7):2073-80. Epub 2005 May 11.
50. The effects of angiotensin IV analogs on long-term potentiation within the CA1 region of the hippocampus in vitro. Kramar EA, etal., Brain Res. 2001 Apr 6;897(1-2):114-21.
51. Upregulation of a local renin-angiotensin system in the rat carotid body during chronic intermittent hypoxia. Lam SY, etal., Exp Physiol. 2014 Jan;99(1):220-31. doi: 10.1113/expphysiol.2013.074591. Epub 2013 Sep 13.
52. Targeting the renin-angiotensin system: what's new? Leckie BJ Curr Med Chem Cardiovasc Hematol Agents. 2005 Jan;3(1):23-32.
53. Angiotensin II increases periostin expression via Ras/p38 MAPK/CREB and ERK1/2/TGF-{beta}1 pathways in cardiac fibroblasts. Li L, etal., Cardiovasc Res. 2011 Mar 2.
54. Increased renin excretion is associated with augmented urinary angiotensin II levels in chronic angiotensin II-infused hypertensive rats. Liu L, etal., Am J Physiol Renal Physiol. 2011 Dec;301(6):F1195-201. doi: 10.1152/ajprenal.00339.2011. Epub 2011 Aug 24.
55. Brain-specific restoration of angiotensin II corrects renal defects seen in angiotensinogen-deficient mice. Lochard N, etal., J Biol Chem 2003 Jan 24;278(4):2184-9. Epub 2002 Oct 23.
56. The expression of angiotensin-converting enzyme 2-angiotensin-(1-7)-Mas receptor axis are upregulated after acute cerebral ischemic stroke in rats. Lu J, etal., Neuropeptides. 2013 Oct;47(5):289-95. doi: 10.1016/j.npep.2013.09.002. Epub 2013 Sep 18.
57. Effect of GPE-AGT nanoparticle shRNA transfection system mediated RNAi on early atherosclerotic lesion. Lu P, etal., Int J Clin Exp Pathol. 2012;5(7):698-706. Epub 2012 Sep 5.
58. Expression of angiotensinogen during hepatic fibrogenesis and its effect on hepatic stellate cells. Lu P, etal., Med Sci Monit. 2011 Sep;17(9):BR248-56.
59. Angiotensin II receptor blockade inhibits pneumocyte apoptosis in experimental meconium aspiration. Lukkarinen H, etal., Pediatr Res. 2004 Feb;55(2):326-33. Epub 2003 Nov 6.
60. [Renin-angiotensin system in mesenteric adipose tissues in rats with metabolic syndrome] Ma LQ, etal., Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2006 Dec;28(6):770-5.
61. [Angiotensinogen gene T174M polymorphism: opposite relationships with essential hypertension and obesity in a homogeneous population from Majorca (Baleric Islands, Spain)] Marco J, etal., Nefrologia. 2005;25(6):629-36.
62. Adipose angiotensinogen is involved in adipose tissue growth and blood pressure regulation. Massiera F, etal., FASEB J. 2001 Dec;15(14):2727-9. Epub 2001 Oct 15.
63. Upregulation of Brain Renin Angiotensin System by 27-Hydroxycholesterol in Alzheimer's Disease. Mateos L, etal., J Alzheimers Dis. 2011 Feb 4.
64. Angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas axis protects against lung fibrosis by inhibiting the MAPK/NF-kappaB pathway. Meng Y, etal., Am J Respir Cell Mol Biol. 2014 Apr;50(4):723-36. doi: 10.1165/rcmb.2012-0451OC.
65. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
66. MGDs mouse GO annotations MGD data from the GO Consortium
67. MGD IEA MGD IEA
68. Evaluation of kidney dysfunction and angiotensinogen as an early novel biomarker of intrauterine growth restricted offspring rats. Murano Y, etal., Pediatr Res. 2015 Dec;78(6):678-82. doi: 10.1038/pr.2015.153. Epub 2015 Aug 13.
69. Nephrogenesis and renovascular development in angiotensinogen-deficient mice. Nagata M, etal., Lab Invest. 1996 Nov;75(5):745-53.
70. Activation of cardiac renin-angiotensin system in unstable angina. Neri Serneri GG, etal., J Am Coll Cardiol. 2001 Jul;38(1):49-55.
71. ACE2 and ANG-(1-7) in the rat uterus during early and late gestation. Neves LA, etal., Am J Physiol Regul Integr Comp Physiol. 2008 Jan;294(1):R151-61. Epub 2007 Oct 31.
72. Homozygosity for angiotensinogen 235T variant increases the risk of myocardial infarction in patients with multi-vessel coronary artery disease. Olivieri O, etal., J Hypertens. 2001 May;19(5):879-84.
73. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
74. Renin-angiotensin system gene polymorphisms: association with susceptibility to Henoch-Schonlein purpura and renal involvement. Ozkaya O, etal., Clin Rheumatol. 2006 Nov;25(6):861-5. Epub 2006 Mar 7.
75. AT2 receptors: beneficial counter-regulatory role in cardiovascular and renal function. Padia SH and Carey RM, Pflugers Arch. 2013 Jan;465(1):99-110. doi: 10.1007/s00424-012-1146-3. Epub 2012 Sep 5.
76. Renal angiotensin type 2 receptors mediate natriuresis via angiotensin III in the angiotensin II type 1 receptor-blocked rat. Padia SH, etal., Hypertension. 2006 Mar;47(3):537-44. Epub 2005 Dec 27.
77. Survival in type 2 diabetic patients in dialysis and the number of risk alleles in polymorphisms of the renin-angiotensin system genes. Padro-Miquel A, etal., Clin Biochem. 2009 Jan;42(1-2):5-11. doi: 10.1016/j.clinbiochem.2008.10.011. Epub 2008 Nov 5.
78. The predominant role of brain angiotensinogen and angiotensin in environmentally induced hypertension. Peng J, etal., Regul Pept 2002 Dec 31;110(1):25-32.
79. Reduction of cold-induced hypertension by antisense oligodeoxynucleotides to angiotensinogen mRNA and AT1-receptor mRNA in brain and blood. Peng JF, etal., Hypertension. 1998 Jun;31(6):1317-23.
80. Reduced circulating levels of angiotensin-(1--7) in systemic sclerosis: a new pathway in the dysregulation of endothelial-dependent vascular tone control. Pignone A, etal., Ann Rheum Dis. 2007 Oct;66(10):1305-10. Epub 2007 Mar 14.
81. Angiotensinogen M235T and T174M gene polymorphisms in combination doubles the risk of mortality in heart failure. Pilbrow AP, etal., Hypertension. 2007 Feb;49(2):322-7. Epub 2006 Dec 4.
82. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
83. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
84. Genetic analysis of angiotensinogen gene polymorphisms (M235T and T174M) in Romanian patients with essential arterial hypertension. Procopciuc LM, etal., Rom J Intern Med. 2005;43(1-2):61-71.
85. Angiotensin III: a central regulator of vasopressin release and blood pressure. Reaux A, etal., Trends Endocrinol Metab. 2001 May-Jun;12(4):157-62.
86. The continuing saga of the AT2 receptor: a case of the good, the bad, and the innocuous. Reudelhuber TL Hypertension. 2005 Dec;46(6):1261-2. Epub 2005 Nov 14.
87. Mouse MP Annotation Import Pipeline RGD automated import pipeline
88. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
89. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
90. Role of angiotensin II in ischemia/reperfusion-induced leukocyte-endothelium interactions in the colon. Riaz AA, etal., FASEB J. 2004 May;18(7):881-3. doi: 10.1096/fj.03-0502fje. Epub 2004 Mar 4.
91. Polymorphisms of the renin-angiotensin system are associated with blood pressure, atherosclerosis and cerebral white matter pathology. Rijn MJ, etal., J Neurol Neurosurg Psychiatry. 2007 Jan 12;.
92. AT-1 receptor and phospholipase C are involved in angiotensin III modulation of hypothalamic noradrenergic transmission. Rodriguez-Campos M, etal., Cell Mol Neurobiol. 2000 Dec;20(6):747-62.
93. Role of IL-6 in angiotensin II-induced retinal vascular inflammation. Rojas M, etal., Invest Ophthalmol Vis Sci. 2010 Mar;51(3):1709-18. doi: 10.1167/iovs.09-3375. Epub 2009 Oct 15.
94. Effects of imatinib mesylate on renin-angiotensin system (RAS) activity during the clinical course of chronic myeloid leukaemia. Sayitoglu M, etal., J Int Med Res. 2009 Jul-Aug;37(4):1018-28.
95. Angiotensinogen M235T polymorphism and the risk of myocardial infarction and stroke among hypertensive patients on ACE-inhibitors or beta-blockers. Schelleman H, etal., Eur J Hum Genet. 2007 Apr;15(4):478-84. Epub 2007 Feb 14.
96. No evidence for association between the renin-angiotensin-aldosterone system and otosclerosis in a large Belgian-Dutch population. Schrauwen I, etal., Otol Neurotol. 2009 Dec;30(8):1079-83. doi: 10.1097/MAO.0b013e3181ab3058.
97. Polymorphisms of renin-angiotensin system genes as a risk factor for high-altitude pulmonary oedema. Stobdan T, etal., J Renin Angiotensin Aldosterone Syst. 2011 Mar 10.
98. Angiotensin-(1-7) inhibits vascular calcification in rats. Sui YB, etal., Peptides. 2013 Apr;42:25-34. doi: 10.1016/j.peptides.2012.12.023. Epub 2013 Jan 3.
99. Salt-induced renal injury in SHRs is mediated by AT1 receptor activation. Susic D, etal., J Hypertens. 2011 Apr;29(4):716-23.
100. Angiotensinogen gene polymorphism (Met235Thr) influences visceral obesity and insulin resistance in obese Japanese women. Takakura Y, etal., Metabolism. 2006 Jun;55(6):819-24.
101. Angiotensin-(1-7) inhibits growth of cardiac myocytes through activation of the mas receptor. Tallant EA, etal., Am J Physiol Heart Circ Physiol. 2005 Oct;289(4):H1560-6. Epub 2005 Jun 10.
102. The role of HIF-1, angiopoietin-2, Dll4 and Notch1 in bleeding gastrointestinal vascular malformations and thalidomide-associated actions: a pilot in vivo study. Tan HH, etal., J Dig Dis. 2011 Oct;12(5):349-56. doi: 10.1111/j.1751-2980.2011.00506.x.
103. Polymorphisms within the angiotensinogen gene (GT-repeat) and the risk of stroke in pediatric patients with sickle cell disease: a case-control study. Tang DC, etal., Am J Hematol. 2001 Nov;68(3):164-9.
104. Angiotensinogen-deficient mice with hypotension. Tanimoto K, etal., J Biol Chem. 1994 Dec 16;269(50):31334-7.
105. Renin-angiotensin system gene polymorphisms and atrial fibrillation: a regression approach for the detection of gene-gene interactions in a large hospitalized population. Tsai CT, etal., Cardiology. 2008;111(1):1-7. doi: 10.1159/000113419. Epub 2008 Feb 1.
106. Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes. Tsuchida S, etal., J Clin Invest 1998 Feb 15;101(4):755-60.
107. Addition of angiotensin II type 1 receptor blocker to CCR2 antagonist markedly attenuates crescentic glomerulonephritis. Urushihara M, etal., Hypertension. 2011 Mar;57(3):586-93. Epub 2011 Jan 31.
108. Inhibition of corneal neovascularization by blocking the angiotensin II type 1 receptor. Usui T, etal., Invest Ophthalmol Vis Sci. 2008 Oct;49(10):4370-6. doi: 10.1167/iovs.07-0964.
109. Genetic polymorphisms of the renin-angiotensin system and complications of insulin-dependent diabetes mellitus. van Ittersum FJ, etal., Nephrol Dial Transplant. 2000 Jul;15(7):1000-7.
110. Angiotensinogen promoter sequence variants in essential hypertension. Velez DR, etal., Am J Hypertens. 2006 Dec;19(12):1278-85.
111. ACE2 and Ang-(1-7) confer protection against development of diabetic retinopathy. Verma A, etal., Mol Ther. 2012 Jan;20(1):28-36. doi: 10.1038/mt.2011.155. Epub 2011 Jul 26.
112. A molecular variant of angiotensinogen associated with preeclampsia. Ward K, etal., Nat Genet 1993 May;4(1):59-61.
113. Angiotensin II controls occludin function and is required for blood brain barrier maintenance: relevance to multiple sclerosis. Wosik K, etal., J Neurosci. 2007 Aug 22;27(34):9032-42.
114. Lack of association of polymorphisms of the angiotensin converting enzyme and angiotensinogen genes with nonfamilial hypertrophic or dilated cardiomyopathy. Yamada Y, etal., Am J Hypertens. 1997 Aug;10(8):921-8.
115. Mechanisms of Ghrelin anti-heart failure: inhibition of Ang II-induced cardiomyocyte apoptosis by down-regulating AT1R expression. Yang C, etal., PLoS One. 2014 Jan 21;9(1):e85785. doi: 10.1371/journal.pone.0085785. eCollection 2014.
116. Activation of the renin-angiotensin system in anti-glomerular basement membrane antibody-induced glomerulonephritis. Yayama K, etal., Biol Pharm Bull. 1995 Mar;18(3):411-5.
117. Elevation of plasma angiotensinogen in rats with experimentally induced nephrosis. Yayama K, etal., Nephron. 1993;63(1):89-93.
118. Olmesartan attenuates cardiac remodeling through DLL4/Notch1 pathway activation in pressure overload mice. You J, etal., J Cardiovasc Pharmacol. 2013 Feb;61(2):142-51. doi: 10.1097/FJC.0b013e31827a0278.
119. Impairment of Cardiac Function and Remodeling Induced by Myocardial Infarction in Rats are Attenuated by the Nonpeptide Angiotensin-(1-7) Analog AVE 0991. Zeng WT, etal., Cardiovasc Ther. 2010 Dec 19. doi: 10.1111/j.1755-5922.2010.00255.x.
120. Angiotensin (1-7) protects against stress-induced gastric lesions in rats. Zhu D, etal., Biochem Pharmacol. 2014 Feb 1;87(3):467-76. doi: 10.1016/j.bcp.2013.10.026. Epub 2013 Nov 11.
121. Regulation of angiotensin-(1-7) and angiotensin II type 1 receptor by telmisartan and losartan in adriamycin-induced rat heart failure. Zong WN, etal., Acta Pharmacol Sin. 2011 Nov;32(11):1345-50. doi: 10.1038/aps.2011.96. Epub 2011 Oct 3.
Additional References at PubMed
PMID:1628813   PMID:2175614   PMID:2563581   PMID:2573515   PMID:2792385   PMID:3397061   PMID:7708716   PMID:8093670   PMID:8170956   PMID:8228167   PMID:8675666   PMID:8889548  
PMID:8952516   PMID:9039002   PMID:9077534   PMID:9196031   PMID:9310306   PMID:9316207   PMID:9507198   PMID:9507206   PMID:9557921   PMID:9612331   PMID:9734405   PMID:9788961  
PMID:9837754   PMID:9837769   PMID:9852267   PMID:9876285   PMID:9878677   PMID:9884332   PMID:9889347   PMID:9931123   PMID:9973259   PMID:10076178   PMID:10081975   PMID:10205143  
PMID:10318840   PMID:10349636   PMID:10358057   PMID:10405217   PMID:10425188   PMID:10585456   PMID:10603124   PMID:10604517   PMID:10615411   PMID:10617578   PMID:10625648   PMID:10642587  
PMID:10720939   PMID:10775573   PMID:10922068   PMID:11015607   PMID:11042159   PMID:11076861   PMID:11096065   PMID:11124149   PMID:11133514   PMID:11217851   PMID:11292619   PMID:11384650  
PMID:11427512   PMID:11468771   PMID:11551931   PMID:11713218   PMID:11776396   PMID:12051830   PMID:12388794   PMID:12431444   PMID:12466851   PMID:12468582   PMID:12477932   PMID:12574102  
PMID:12657564   PMID:12660889   PMID:12691672   PMID:12909574   PMID:14599720   PMID:14749209   PMID:15067320   PMID:15117826   PMID:15153562   PMID:15173164   PMID:15189777   PMID:15201545  
PMID:15302839   PMID:15499027   PMID:15695374   PMID:15699465   PMID:15710982   PMID:15849235   PMID:15922295   PMID:16109805   PMID:16115031   PMID:16141072   PMID:16141073   PMID:16189718  
PMID:16260600   PMID:16374517   PMID:16528251   PMID:16582578   PMID:16585392   PMID:16602821   PMID:16675600   PMID:16723697   PMID:16796982   PMID:16859699   PMID:16887177   PMID:16889841  
PMID:16930545   PMID:17019806   PMID:17307998   PMID:17434545   PMID:17633135   PMID:17919982   PMID:17932313   PMID:17962626   PMID:17962627   PMID:17965276   PMID:17982475   PMID:18025526  
PMID:18033753   PMID:18057217   PMID:18158355   PMID:18158357   PMID:18164957   PMID:18174462   PMID:18216149   PMID:18287219   PMID:18287559   PMID:18309113   PMID:18391091   PMID:18441099  
PMID:18474814   PMID:18483625   PMID:18495795   PMID:18497303   PMID:18544999   PMID:18579707   PMID:18600297   PMID:18650792   PMID:18768397   PMID:18824665   PMID:18832438   PMID:18923387  
PMID:18930063   PMID:18931513   PMID:18948399   PMID:18974301   PMID:19023134   PMID:19047580   PMID:19073907   PMID:19074984   PMID:19196803   PMID:19404405   PMID:19478206   PMID:19546355  
PMID:19564856   PMID:19673938   PMID:19782130   PMID:19846569   PMID:19889957   PMID:19939975   PMID:19948988   PMID:19948989   PMID:19961928   PMID:20071356   PMID:20093323   PMID:20164204  
PMID:20357030   PMID:20362292   PMID:20363893   PMID:20376577   PMID:20413721   PMID:20496471   PMID:20580688   PMID:20684663   PMID:20823378   PMID:20833395   PMID:20861465   PMID:20970401  
PMID:21055442   PMID:21109230   PMID:21183621   PMID:21193590   PMID:21203566   PMID:21267068   PMID:21307128   PMID:21367916   PMID:21481872   PMID:21487074   PMID:21501583   PMID:21641389  
PMID:21651842   PMID:21774352   PMID:21844485   PMID:21846974   PMID:21871425   PMID:21873635   PMID:22057271   PMID:22071160   PMID:22072715   PMID:22234465   PMID:22237801   PMID:22288735  
PMID:22293193   PMID:22301625   PMID:22474255   PMID:22518004   PMID:22547438   PMID:22550170   PMID:22628375   PMID:22664868   PMID:22673782   PMID:22749815