AGT (angiotensinogen) - Rat Genome Database

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Gene: AGT (angiotensinogen) Sus scrofa
Analyze
Symbol: AGT
Name: angiotensinogen
RGD ID: 14230380
Description: ENCODES a protein that exhibits hormone activity (ortholog); receptor ligand activity (ortholog); sodium channel regulator activity (ortholog); INVOLVED IN activation of NF-kappaB-inducing kinase activity (ortholog); activation of phospholipase C activity (ortholog); aging (ortholog); PARTICIPATES IN angiotensin (1-7) signaling pathway; angiotensin II signaling pathway; angiotensin II signaling pathway via AT1 receptor; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); Albuminuria (ortholog); alcoholic cardiomyopathy (ortholog); FOUND IN cytoplasm (ortholog); extracellular space (ortholog); mitochondrion (ortholog); INTERACTS WITH aldosterone; clofibrate; cortisol
Type: protein-coding
RefSeq Status: MODEL
Also known as: angiotensinogen (serpin peptidase inhibitor, clade A, member 8); serpin peptidase inhibitor, clade A, member 8
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1459,643,292 - 59,672,428 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11459,643,030 - 59,656,835 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21464,380,799 - 64,385,995 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Albuminuria  (ISO)
alcoholic cardiomyopathy  (ISO)
alcoholic hepatitis  (ISO)
Alkalosis  (ISO)
Allanson Pantzar McLeod Syndrome  (ISO)
allergic disease  (ISO)
Alzheimer's disease  (ISO)
Anaphylaxis  (ISO)
anemia  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
anuria  (ISO)
aortic aneurysm  (ISO)
Aortic Calcification  (ISO)
Aortic Coarctation  (ISO)
atherosclerosis  (ISO)
atrial fibrillation  (ISO)
Bradycardia  (ISO)
breast cancer  (ISO)
Cardiac Arrhythmias  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
Cardiotoxicity  (ISO)
Cardiovascular Abnormalities  (ISO)
cardiovascular system disease  (ISO)
carotid artery disease  (ISO)
Catalepsy  (ISO)
cerebrovascular disease  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholestasis  (ISO)
Chronic Intermittent Hypoxia  (ISO)
chronic myeloid leukemia  (ISO)
cognitive disorder  (ISO)
congestive heart failure  (ISO)
corneal neovascularization  (ISO)
COVID-19  (ISO)
Crohn's disease  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
Diaphragmatic Hernia  (ISO)
diffuse scleroderma  (ISO)
dilated cardiomyopathy  (ISO)
Dissecting Aneurysm  (ISO)
Drug Overdose  (ISO)
endomyocardial fibrosis  (ISO)
essential hypertension  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Fabry disease  (ISO)
Fetal Growth Retardation  (ISO)
Fibrosis  (ISO)
focal segmental glomerulosclerosis  (ISO)
gastric ulcer  (ISO)
gastrointestinal stromal tumor  (ISO)
glomerulonephritis  (ISO)
glucose intolerance  (ISO)
heart disease  (ISO)
Hemorrhage  (ISO)
Henoch-Schoenlein purpura  (ISO)
hydronephrosis  (ISO)
Hyperalgesia  (ISO)
Hyperemia  (ISO)
hyperhomocysteinemia  (ISO)
hyperinsulinism  (ISO)
hypertension  (ISO)
Hypertensive Nephropathy  (ISO)
hypertrophic cardiomyopathy  (ISO)
Hypertrophy  (ISO)
hypokalemia  (ISO)
Hypotension  (ISO)
IgA glomerulonephritis  (ISO)
impotence  (ISO)
Inflammation  (ISO)
inflammatory bowel disease  (ISO)
intermediate coronary syndrome  (ISO)
Intestinal Reperfusion Injury  (ISO)
kidney disease  (ISO)
kidney failure  (ISO)
Left Ventricular Hypertrophy  (ISO)
liver cirrhosis  (ISO)
malignant hypertension  (ISO)
Mammary Neoplasms, Experimental  (ISO)
meconium aspiration syndrome  (ISO)
Metabolic Syndrome  (ISO)
microcephaly  (ISO)
middle cerebral artery infarction  (ISO)
mitral valve prolapse  (ISO)
multiple sclerosis  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
Necrosis  (ISO)
Neointima  (ISO)
nephrosis  (ISO)
Neurobehavioral Manifestations  (ISO)
obesity  (ISO)
otosclerosis  (ISO)
parathyroid carcinoma  (ISO)
Peptic Ulcer Hemorrhage  (ISO)
pneumonia  (ISO)
polycystic kidney disease  (ISO)
pre-eclampsia  (ISO)
prediabetes syndrome  (ISO)
Pregnancy-Induced Hypertension  (ISO)
primary biliary cholangitis  (ISO)
proteinuria  (ISO)
pulmonary edema  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
Puromycin Aminonucleoside Nephrosis  (ISO)
renal hypertension  (ISO)
Renal Tubular Dysgenesis  (ISO)
Reperfusion Injury  (ISO)
retinal vasculitis  (ISO)
retinopathy of prematurity  (ISO)
sciatic neuropathy  (ISO)
sick sinus syndrome  (ISO)
skin melanoma  (ISO)
Stroke  (ISO)
Sudden Death  (ISO)
systemic scleroderma  (ISO)
temporal lobe epilepsy  (ISO)
thrombosis  (ISO)
transient cerebral ischemia  (ISO)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (ISO)
vascular disease  (ISO)
Vascular Remodeling  (ISO)
Ventricular Dysfunction, Left  (ISO)
Ventricular Remodeling  (ISO)
visual epilepsy  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of NF-kappaB-inducing kinase activity  (ISO)
activation of phospholipase C activity  (ISO)
aging  (ISO)
aldosterone secretion  (ISO)
angiotensin-activated signaling pathway  (ISO)
angiotensin-mediated drinking behavior  (ISO)
angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure  (ISO)
artery smooth muscle contraction  (ISO)
associative learning  (ISO)
astrocyte activation  (ISO)
blood vessel development  (ISO)
brain renin-angiotensin system  (ISO)
branching involved in ureteric bud morphogenesis  (ISO)
cell growth involved in cardiac muscle cell development  (ISO)
cell surface receptor signaling pathway  (ISO)
cell-matrix adhesion  (ISO)
cellular response to angiotensin  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular sodium ion homeostasis  (ISO)
cytokine production  (ISO)
drinking behavior  (ISO)
ERK1 and ERK2 cascade  (ISO)
establishment of blood-nerve barrier  (ISO)
extracellular matrix organization  (ISO)
female pregnancy  (ISO)
fibroblast proliferation  (ISO)
G protein-coupled receptor signaling pathway  (IEA,ISO)
hormone metabolic process  (ISO)
kidney development  (IEA,ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of endopeptidase activity  (IBA,IEA)
negative regulation of gene expression  (ISO)
negative regulation of MAP kinase activity  (IEA)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of neurotrophin TRK receptor signaling pathway  (IEA)
negative regulation of tissue remodeling  (ISO)
operant conditioning  (ISO)
ovarian follicle rupture  (ISO)
peristalsis  (ISO)
positive regulation of activation of Janus kinase activity  (IEA)
positive regulation of blood pressure  (ISO)
positive regulation of branching involved in ureteric bud morphogenesis  (IEA)
positive regulation of cardiac muscle cell apoptotic process  (ISO)
positive regulation of cardiac muscle hypertrophy  (ISO)
positive regulation of catalytic activity  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cellular protein metabolic process  (IEA)
positive regulation of cholesterol esterification  (IEA)
positive regulation of cytokine production  (ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of endothelial cell migration  (IEA)
positive regulation of epidermal growth factor receptor signaling pathway  (IEA)
positive regulation of extracellular matrix constituent secretion  (ISO)
positive regulation of extrinsic apoptotic signaling pathway  (IEA)
positive regulation of fatty acid biosynthetic process  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of gap junction assembly  (IEA)
positive regulation of gene expression  (ISO)
positive regulation of insulin receptor signaling pathway  (ISO)
positive regulation of L-arginine import across plasma membrane  (ISO)
positive regulation of L-lysine import across plasma membrane  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of membrane hyperpolarization  (ISO)
positive regulation of multicellular organism growth  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of organ growth  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (IEA)
positive regulation of phosphatidylinositol 3-kinase signaling  (IEA)
positive regulation of protein kinase C activity  (ISO)
positive regulation of protein tyrosine kinase activity  (IEA)
positive regulation of renal sodium excretion  (ISO)
positive regulation of superoxide anion generation  (ISO)
positive regulation of transcription, DNA-templated  (IEA)
positive regulation of vascular associated smooth muscle cell migration  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
protein import into nucleus  (ISO)
regulation of apoptotic process  (IBA,ISO)
regulation of blood pressure  (IEA,ISO)
regulation of calcium ion transport  (ISO)
regulation of cardiac conduction  (IEA)
regulation of extracellular matrix assembly  (IEA)
regulation of gene expression  (ISO)
regulation of heart rate  (ISO)
regulation of inflammatory response  (ISO)
regulation of long-term neuronal synaptic plasticity  (ISO)
regulation of norepinephrine secretion  (ISO)
regulation of renal output by angiotensin  (ISO)
regulation of renal sodium excretion  (ISO)
regulation of systemic arterial blood pressure by circulatory renin-angiotensin  (ISO)
regulation of systemic arterial blood pressure by renin-angiotensin  (IEA)
regulation of transmission of nerve impulse  (ISO)
renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure  (ISO)
renal system process  (IEA)
renin-angiotensin regulation of aldosterone production  (ISO)
response to cold  (ISO)
response to estradiol  (ISO)
response to muscle activity involved in regulation of muscle adaptation  (ISO)
response to salt stress  (ISO)
smooth muscle cell differentiation  (ISO)
smooth muscle cell proliferation  (ISO)
stress-activated MAPK cascade  (ISO)
uterine smooth muscle contraction  (ISO)
vasoconstriction  (IEA,ISO)
vasodilation  (ISO)
vasopressin secretion  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:16390332   PMID:17145712   PMID:18310517   PMID:18331442   PMID:27443965  


Genomics

Comparative Map Data
AGT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1459,643,292 - 59,672,428 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11459,643,030 - 59,656,835 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21464,380,799 - 64,385,995 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AGT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1230,690,776 - 230,745,576 (-)EnsemblGRCh38hg38GRCh38
GRCh381230,702,523 - 230,745,583 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371230,838,269 - 230,881,329 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361228,904,892 - 228,916,564 (-)NCBINCBI36hg18NCBI36
Build 341227,145,019 - 227,156,602NCBI
Celera1204,104,291 - 204,116,358 (-)NCBI
Cytogenetic Map1q42.2NCBI
HuRef1201,323,209 - 201,335,277 (-)NCBIHuRef
CHM1_11232,111,282 - 232,123,349 (-)NCBICHM1_1
Agt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398125,283,326 - 125,296,445 (-)NCBIGRCm39mm39
GRCm39 Ensembl8125,283,273 - 125,296,445 (-)Ensembl
GRCm388124,556,587 - 124,569,706 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8124,556,534 - 124,569,706 (-)EnsemblGRCm38mm10GRCm38
MGSCv378127,080,487 - 127,093,607 (-)NCBIGRCm37mm9NCBIm37
MGSCv368127,442,677 - 127,455,773 (-)NCBImm8
Celera8128,860,995 - 128,873,954 (-)NCBICelera
Cytogenetic Map8E2NCBI
cM Map872.81NCBI
Agt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21952,529,139 - 52,549,618 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1952,529,185 - 52,540,977 (-)Ensembl
Rnor_6.01957,321,594 - 57,333,460 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1957,321,640 - 57,333,433 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01968,026,182 - 68,038,550 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41954,738,556 - 54,750,349 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11954,743,436 - 54,755,230 (-)NCBI
Celera1951,899,180 - 51,910,819 (-)NCBICelera
Cytogenetic Map19q12NCBI
Agt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554927,866,833 - 7,873,357 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554927,863,662 - 7,874,863 (+)NCBIChiLan1.0ChiLan1.0
AGT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11211,279,015 - 211,291,044 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1211,279,015 - 211,291,044 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01206,252,141 - 206,263,830 (-)NCBIMhudiblu_PPA_v0panPan3
AGT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.148,681,192 - 8,694,059 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl48,683,798 - 8,693,880 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha48,672,874 - 8,685,743 (+)NCBI
ROS_Cfam_1.048,705,485 - 8,718,357 (+)NCBI
ROS_Cfam_1.0 Ensembl48,705,603 - 8,718,382 (+)Ensembl
UMICH_Zoey_3.148,709,653 - 8,722,523 (+)NCBI
UNSW_CanFamBas_1.048,831,567 - 8,844,457 (+)NCBI
UU_Cfam_GSD_1.049,061,768 - 9,074,658 (+)NCBI
Agt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934443,547,972 - 43,555,916 (+)NCBI
SpeTri2.0NW_00493648419,713,299 - 19,721,144 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AGT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12567,964,840 - 67,977,006 (-)NCBIChlSab1.1chlSab2
ChlSab1.12567,964,840 - 67,977,006 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2567,962,401 - 67,973,324 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605569,870,396 - 69,882,850 (-)NCBIVero_WHO_p1.0
Agt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477518,846,222 - 18,856,093 (+)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1 19
Low 10 3 3 4 2 4 1 1
Below cutoff 1 1 2 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000011150   ⟹   ENSSSCP00000010861
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1459,643,300 - 59,672,428 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000036625   ⟹   ENSSSCP00000029872
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1459,648,471 - 59,672,428 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000050329   ⟹   ENSSSCP00000044037
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1459,643,292 - 59,653,040 (+)Ensembl
RefSeq Acc Id: XM_021073990   ⟹   XP_020929649
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11459,643,030 - 59,656,835 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020929649 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_020929649   ⟸   XM_021073990
- Sequence:
RefSeq Acc Id: ENSSSCP00000044037   ⟸   ENSSSCT00000050329
RefSeq Acc Id: ENSSSCP00000010861   ⟸   ENSSSCT00000011150
RefSeq Acc Id: ENSSSCP00000029872   ⟸   ENSSSCT00000036625
Protein Domains
SERPIN


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000010184 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070015511 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000010861 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000029872 UniProtKB/TrEMBL
  ENSSSCP00000044037 UniProtKB/TrEMBL
  ENSSSCP00070025388 UniProtKB/TrEMBL
  ENSSSCP00070025395 UniProtKB/TrEMBL
  ENSSSCP00070025400 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000011150 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000036625 UniProtKB/TrEMBL
  ENSSSCT00000050329 UniProtKB/TrEMBL
  ENSSSCT00070030443 UniProtKB/TrEMBL
  ENSSSCT00070030451 UniProtKB/TrEMBL
  ENSSSCT00070030455 UniProtKB/TrEMBL
Gene3D-CATH 2.30.39.10 UniProtKB/TrEMBL
  3.30.497.10 UniProtKB/TrEMBL
InterPro Angiotensinogen UniProtKB/TrEMBL
  Serpin_CS UniProtKB/TrEMBL
  Serpin_dom UniProtKB/TrEMBL
  Serpin_fam UniProtKB/TrEMBL
  Serpin_sf UniProtKB/TrEMBL
  Serpin_sf_1 UniProtKB/TrEMBL
  Serpin_sf_2 UniProtKB/TrEMBL
NCBI Gene AGT ENTREZGENE
PANTHER PTHR11461 UniProtKB/TrEMBL
  PTHR11461:SF13 UniProtKB/TrEMBL
Pfam Serpin UniProtKB/TrEMBL
PRINTS ANGIOTENSNGN UniProtKB/TrEMBL
PROSITE SERPIN UniProtKB/TrEMBL
SMART SERPIN UniProtKB/TrEMBL
Superfamily-SCOP SSF56574 UniProtKB/TrEMBL
UniProt A0A287AJ51_PIG UniProtKB/TrEMBL
  A0A4X1UAY5_PIG UniProtKB/TrEMBL
  A0A5K1UCV8_PIG UniProtKB/TrEMBL
  F1RG45_PIG UniProtKB/TrEMBL
UniProt Secondary K7GPQ7 UniProtKB/TrEMBL
VGNC ID VGNC:85190 ENTREZGENE