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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731070
Species: Homo sapiens
RGD Object: Gene
Symbol: AGT
Name: angiotensinogen
Acc ID: CHEBI:8024
Term: perindopril
Definition: An alpha-amino acid ester that is the ethyl ester of N-{(2S)-1-[(2S,3aS,7aS)-2-carboxyoctahydro-1H-indol-1-yl]-1-oxopropan-2-yl}-L-norvaline
Chemical ID: MESH:D020913
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AGTdecreases expressionEXP 6480464CTDPerindopril results in decreased expression of AGT protein alternative formPMID:2549899 PMID:2605800
AGTincreases expressionEXP 6480464CTDPerindopril results in increased expression of AGT protein alternative formPMID:2549899 PMID:2605800
AGTdecreases expressionISOAgt (Rattus norvegicus)6480464CTDPerindopril results in decreased expression of AGT protein; Perindopril results in decreased expression of AGT protein alternative formPMID:34737150 PMID:9808682
AGTincreases expressionISOAgt (Rattus norvegicus)6480464CTDPerindopril results in increased expression of AGT protein alternative formPMID:34737150
AGTmultiple interactionsISOAgt (Rattus norvegicus)6480464CTD[Perindopril co-treated with racecadotril] results in increased expression of AGT protein alternative form; Perindopril inhibits the reaction [Methotrexate results in decreased expression of AGT protein alternative form]; Perindopril inhibits the reaction [Methotrexate results in increased expression of AGT protein]PMID:34737150 PMID:9808682
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