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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731070
Species: Homo sapiens
RGD Object: Gene
Symbol: AGT
Name: angiotensinogen
Acc ID: CHEBI:8499
Term: propranolol
Definition: A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.
Chemical ID: MESH:D011433
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AGTdecreases expressionEXP 6480464CTDPropranolol results in decreased expression of AGT proteinPMID:14627
AGTmultiple interactionsEXP 6480464CTDPropranolol inhibits the reaction [Isoproterenol results in increased expression of AGT protein]; Propranolol inhibits the reaction [REN protein results in increased cleavage of AGT protein]PMID:1653766 PMID:7104148
AGTmultiple interactionsISOAgt (Mus musculus)6480464CTDPropranolol inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]; Propranolol inhibits the reaction [Isoproterenol promotes the reaction [Dexamethasone results in increased expression of AGT protein]]PMID:12606818 PMID:7843740
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