RGD Reference Report - Angiotensin III: a central regulator of vasopressin release and blood pressure. - Rat Genome Database

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Angiotensin III: a central regulator of vasopressin release and blood pressure.

Authors: Reaux, A  Fournie-Zaluski, MC  Llorens-Cortes, C 
Citation: Reaux A, etal., Trends Endocrinol Metab. 2001 May-Jun;12(4):157-62.
RGD ID: 1582124
Pubmed: PMID:11295571   (View Abstract at PubMed)

Among the main bioactive peptides of the brain renin-angiotensin system, angiotensin (Ang) II and AngIII exhibit the same affinity for type 1 and type 2 AngII receptors. Both peptides, injected intracerebroventricularly, cause similar increases in vasopressin release and blood pressure. Because AngII is converted in vivo to AngIII, the identity of the true effector is unknown. This review summarizes new insights into the predominant role of brain AngIII in the control of vasopressin release and blood pressure and underlines the fact that brain aminopeptidase A, the enzyme forming central AngIII, could constitute a putative central therapeutic target for the treatment of hypertension.

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations

Objects Annotated

Genes (Rattus norvegicus)
Agt  (angiotensinogen)
Agtr1a  (angiotensin II receptor, type 1a)
Agtr1b  (angiotensin II receptor, type 1b)
Agtr2  (angiotensin II receptor, type 2)

Genes (Mus musculus)
Agt  (angiotensinogen)
Agtr1b  (angiotensin II receptor, type 1b)
Agtr2  (angiotensin II receptor, type 2)
Aplnr  (apelin receptor)

Genes (Homo sapiens)
AGT  (angiotensinogen)
AGTR1  (angiotensin II receptor type 1)
AGTR2  (angiotensin II receptor type 2)


Additional Information