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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731070
Species: Homo sapiens
RGD Object: Gene
Symbol: AGT
Name: angiotensinogen
Acc ID: CHEBI:4031
Term: cyclosporin A
Definition: A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle.
Chemical ID: MESH:D016572
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AGTdecreases expressionEXP 6480464CTDCyclosporine results in decreased expression of AGT mRNAPMID:20106945 PMID:23830897 PMID:25562108 PMID:27989131
AGTmultiple interactionsEXP 6480464CTD[Cyclosporine co-treated with Cholic Acids] affects the expression of AGT mRNAPMID:27344345
AGTdecreases expressionISOAgt (Mus musculus)6480464CTDCyclosporine results in decreased expression of AGT mRNAPMID:23830897
AGTincreases expressionISOAgt (Rattus norvegicus)6480464CTDCyclosporine results in increased expression of AGT proteinPMID:14659064
AGTmultiple interactionsISOAgt (Rattus norvegicus)6480464CTDEnalapril inhibits the reaction [Cyclosporine results in increased expression of AGT protein]PMID:14659064
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