AGT (angiotensinogen) - Rat Genome Database
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Gene: AGT (angiotensinogen) Pan paniscus
Analyze
Symbol: AGT
Name: angiotensinogen
RGD ID: 12028994
Description: ENCODES a protein that exhibits hormone activity (ortholog); receptor ligand activity (ortholog); sodium channel regulator activity (ortholog); INVOLVED IN activation of MAPK activity (ortholog); activation of NF-kappaB-inducing kinase activity (ortholog); activation of phospholipase C activity (ortholog); PARTICIPATES IN angiotensin (1-7) signaling pathway; angiotensin II signaling pathway; angiotensin II signaling pathway via AT1 receptor; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); Albuminuria (ortholog); alcoholic cardiomyopathy (ortholog); FOUND IN cytoplasm (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11211,279,015 - 211,291,044 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1211,279,015 - 211,291,044 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01206,252,141 - 206,263,830 (-)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Albuminuria  (ISO)
alcoholic cardiomyopathy  (ISO)
alcoholic hepatitis  (ISO)
Alkalosis  (ISO)
Allanson Pantzar McLeod Syndrome  (ISO)
allergic disease  (ISO)
Alzheimer's disease  (ISO)
Anaphylaxis  (ISO)
anemia  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
anuria  (ISO)
aortic aneurysm  (ISO)
Aortic Calcification  (ISO)
Aortic Coarctation  (ISO)
atherosclerosis  (ISO)
atrial fibrillation  (ISO)
Bradycardia  (ISO)
breast cancer  (ISO)
Cardiac Arrhythmias  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
Cardiovascular Abnormalities  (ISO)
cardiovascular system disease  (ISO)
carotid artery disease  (ISO)
Catalepsy  (ISO)
cerebrovascular disease  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholestasis  (ISO)
Chronic Intermittent Hypoxia  (ISO)
chronic myeloid leukemia  (ISO)
cognitive disorder  (ISO)
congestive heart failure  (ISO)
corneal neovascularization  (ISO)
Crohn's disease  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
Diaphragmatic Hernia  (ISO)
diffuse scleroderma  (ISO)
dilated cardiomyopathy  (ISO)
Dissecting Aneurysm  (ISO)
Drug Overdose  (ISO)
endomyocardial fibrosis  (ISO)
essential hypertension  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Fabry disease  (ISO)
Fetal Growth Retardation  (ISO)
Fibrosis  (ISO)
focal segmental glomerulosclerosis  (ISO)
gastric ulcer  (ISO)
glomerulonephritis  (ISO)
glucose intolerance  (ISO)
heart disease  (ISO)
Hemorrhage  (ISO)
Henoch-Schoenlein purpura  (ISO)
hydronephrosis  (ISO)
Hyperalgesia  (ISO)
Hyperemia  (ISO)
hyperhomocysteinemia  (ISO)
hyperinsulinism  (ISO)
hypertension  (ISO)
Hypertensive Nephropathy  (ISO)
hypertrophic cardiomyopathy  (ISO)
Hypertrophy  (ISO)
hypokalemia  (ISO)
Hypotension  (ISO)
IgA glomerulonephritis  (ISO)
impotence  (ISO)
Inflammation  (ISO)
inflammatory bowel disease  (ISO)
intermediate coronary syndrome  (ISO)
Intestinal Reperfusion Injury  (ISO)
kidney disease  (ISO)
kidney failure  (ISO)
Left Ventricular Hypertrophy  (ISO)
liver cirrhosis  (ISO)
malignant hypertension  (ISO)
Mammary Neoplasms, Experimental  (ISO)
meconium aspiration syndrome  (ISO)
Metabolic Syndrome  (ISO)
microcephaly  (ISO)
middle cerebral artery infarction  (ISO)
mitral valve prolapse  (ISO)
multiple sclerosis  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
Necrosis  (ISO)
Neointima  (ISO)
nephrosis  (ISO)
Neurobehavioral Manifestations  (ISO)
obesity  (ISO)
otosclerosis  (ISO)
Peptic Ulcer Hemorrhage  (ISO)
pneumonia  (ISO)
polycystic kidney disease  (ISO)
pre-eclampsia  (ISO)
prediabetes syndrome  (ISO)
Pregnancy-Induced Hypertension  (ISO)
primary biliary cholangitis  (ISO)
proteinuria  (ISO)
pulmonary edema  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
Puromycin Aminonucleoside Nephrosis  (ISO)
renal hypertension  (ISO)
Renal Tubular Dysgenesis  (ISO)
Reperfusion Injury  (ISO)
retinal vasculitis  (ISO)
retinopathy of prematurity  (ISO)
sciatic neuropathy  (ISO)
sick sinus syndrome  (ISO)
skin melanoma  (ISO)
Stroke  (ISO)
Sudden Death  (ISO)
systemic scleroderma  (ISO)
temporal lobe epilepsy  (ISO)
thrombosis  (ISO)
transient cerebral ischemia  (ISO)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (ISO)
Vascular Remodeling  (ISO)
Ventricular Dysfunction, Left  (ISO)
Ventricular Remodeling  (ISO)
visual epilepsy  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of MAPK activity  (ISO)
activation of NF-kappaB-inducing kinase activity  (ISO)
activation of phospholipase C activity  (ISO)
aging  (ISO)
angiotensin-activated signaling pathway  (ISO)
angiotensin-mediated drinking behavior  (ISO)
angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure  (ISO)
artery smooth muscle contraction  (ISO)
associative learning  (ISO)
astrocyte activation  (ISO)
blood vessel development  (ISO)
brain renin-angiotensin system  (ISO)
branching involved in ureteric bud morphogenesis  (ISO)
cell growth involved in cardiac muscle cell development  (ISO)
cell surface receptor signaling pathway  (ISO)
cell-matrix adhesion  (ISO)
cellular response to angiotensin  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular sodium ion homeostasis  (ISO)
cytokine production  (ISO)
drinking behavior  (ISO)
ERK1 and ERK2 cascade  (ISO)
establishment of blood-nerve barrier  (ISO)
excretion  (ISO)
extracellular matrix organization  (ISO)
female pregnancy  (ISO)
fibroblast proliferation  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
hormone metabolic process  (ISO)
kidney development  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of MAP kinase activity  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of neurotrophin TRK receptor signaling pathway  (ISO)
negative regulation of tissue remodeling  (ISO)
obsolete positive regulation of blood vessel diameter  (ISO)
operant conditioning  (ISO)
ovarian follicle rupture  (ISO)
peristalsis  (ISO)
positive regulation of activation of Janus kinase activity  (ISO)
positive regulation of blood pressure  (ISO)
positive regulation of branching involved in ureteric bud morphogenesis  (ISO)
positive regulation of cardiac muscle cell apoptotic process  (ISO)
positive regulation of cardiac muscle hypertrophy  (ISO)
positive regulation of catalytic activity  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cellular protein metabolic process  (ISO)
positive regulation of cholesterol esterification  (ISO)
positive regulation of cytokine production  (ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of endothelial cell migration  (ISO)
positive regulation of epidermal growth factor receptor signaling pathway  (ISO)
positive regulation of extracellular matrix constituent secretion  (ISO)
positive regulation of extrinsic apoptotic signaling pathway  (ISO)
positive regulation of fatty acid biosynthetic process  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of gap junction assembly  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of insulin receptor signaling pathway  (ISO)
positive regulation of L-arginine import across plasma membrane  (ISO)
positive regulation of L-lysine import across plasma membrane  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of membrane hyperpolarization  (ISO)
positive regulation of multicellular organism growth  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of organ growth  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase signaling  (ISO)
positive regulation of protein kinase C activity  (ISO)
positive regulation of protein tyrosine kinase activity  (ISO)
positive regulation of renal sodium excretion  (ISO)
positive regulation of superoxide anion generation  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
positive regulation of vascular associated smooth muscle cell migration  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
protein import into nucleus  (ISO)
regulation of apoptotic process  (ISO)
regulation of blood pressure  (ISO)
regulation of calcium ion transport  (ISO)
regulation of cardiac conduction  (ISO)
regulation of extracellular matrix assembly  (ISO)
regulation of gene expression  (ISO)
regulation of heart rate  (ISO)
regulation of inflammatory response  (ISO)
regulation of long-term neuronal synaptic plasticity  (ISO)
regulation of norepinephrine secretion  (ISO)
regulation of renal output by angiotensin  (ISO)
regulation of renal sodium excretion  (ISO)
regulation of systemic arterial blood pressure by circulatory renin-angiotensin  (ISO)
regulation of transmission of nerve impulse  (ISO)
renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure  (ISO)
renal system process  (ISO)
renin-angiotensin regulation of aldosterone production  (ISO)
response to cold  (ISO)
response to estradiol  (ISO)
response to muscle activity involved in regulation of muscle adaptation  (ISO)
response to salt stress  (ISO)
smooth muscle cell differentiation  (ISO)
smooth muscle cell proliferation  (ISO)
stress-activated MAPK cascade  (ISO)
uterine smooth muscle contraction  (ISO)
vasoconstriction  (ISO)
vasodilation  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
AGT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11211,279,015 - 211,291,044 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1211,279,015 - 211,291,044 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01206,252,141 - 206,263,830 (-)NCBIMhudiblu_PPA_v0panPan3
AGT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1230,702,523 - 230,714,122 (-)EnsemblGRCh38hg38GRCh38
GRCh381230,702,523 - 230,745,583 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371230,838,269 - 230,850,336 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361228,904,892 - 228,916,564 (-)NCBINCBI36hg18NCBI36
Build 341227,145,019 - 227,156,602NCBI
Celera1204,104,291 - 204,116,358 (-)NCBI
Cytogenetic Map1q42.2NCBI
HuRef1201,323,209 - 201,335,277 (-)NCBIHuRef
CHM1_11232,111,282 - 232,123,349 (-)NCBICHM1_1
Agt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398125,283,326 - 125,296,445 (-)NCBIGRCm39mm39
GRCm388124,556,587 - 124,569,706 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8124,556,534 - 124,569,706 (-)EnsemblGRCm38mm10GRCm38
MGSCv378127,080,487 - 127,093,607 (-)NCBIGRCm37mm9NCBIm37
MGSCv368127,442,677 - 127,455,773 (-)NCBImm8
Celera8128,860,995 - 128,873,954 (-)NCBICelera
Cytogenetic Map8E2NCBI
cM Map872.81NCBI
Agt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01957,321,594 - 57,333,460 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1957,321,640 - 57,333,433 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01968,026,182 - 68,038,550 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41954,738,556 - 54,750,349 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11954,743,436 - 54,755,230 (-)NCBI
Celera1951,899,180 - 51,910,819 (-)NCBICelera
Cytogenetic Map19q12NCBI
Agt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554927,866,833 - 7,873,357 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554927,863,662 - 7,874,863 (+)NCBIChiLan1.0ChiLan1.0
AGT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl48,683,798 - 8,693,880 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.148,681,192 - 8,694,059 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Agt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493648419,713,299 - 19,721,144 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AGT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1459,643,292 - 59,672,428 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11459,643,030 - 59,656,835 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21464,380,799 - 64,385,995 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AGT
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl2567,962,401 - 67,973,324 (-)Ensembl
ChlSab1.12567,964,840 - 67,977,006 (-)NCBI
Agt
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477518,846,222 - 18,856,093 (+)NCBI


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_003824464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide SSBP01000279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSPPAT00000030624   ⟹   ENSPPAP00000007994
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1211,279,015 - 211,291,044 (-)Ensembl
RefSeq Acc Id: XM_003824464   ⟹   XP_003824512
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.11211,279,015 - 211,291,044 (-)NCBI
Mhudiblu_PPA_v01206,252,141 - 206,263,830 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003824512 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003824512   ⟸   XM_003824464
- Sequence:
RefSeq Acc Id: ENSPPAP00000007994   ⟸   ENSPPAT00000030624
Protein Domains
SERPIN


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000027230 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000007994 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000030624 UniProtKB/TrEMBL
Gene3D-CATH 2.30.39.10 UniProtKB/TrEMBL
  3.30.497.10 UniProtKB/TrEMBL
InterPro Angiotensinogen UniProtKB/TrEMBL
  Angiotensinogen_serpin UniProtKB/TrEMBL
  Serpin_CS UniProtKB/TrEMBL
  Serpin_dom UniProtKB/TrEMBL
  Serpin_fam UniProtKB/TrEMBL
  Serpin_sf UniProtKB/TrEMBL
  Serpin_sf_1 UniProtKB/TrEMBL
  Serpin_sf_2 UniProtKB/TrEMBL
KEGG Report pps:100990550 UniProtKB/TrEMBL
NCBI Gene AGT ENTREZGENE
PANTHER PTHR11461 UniProtKB/TrEMBL
  PTHR11461:SF13 UniProtKB/TrEMBL
Pfam Serpin UniProtKB/TrEMBL
PRINTS ANGIOTENSNGN UniProtKB/TrEMBL
PROSITE SERPIN UniProtKB/TrEMBL
SMART SERPIN UniProtKB/TrEMBL
Superfamily-SCOP SSF56574 UniProtKB/TrEMBL
UniProt A0A2R8ZSQ3_PANPA UniProtKB/TrEMBL