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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2069
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Agt
Name: angiotensinogen
Acc ID: CHEBI:8714
Term: quinapril hydrochloride
Definition: A hydrochloride resulting from the reaction of equimolar amounts of quinapril and hydrogen chloride. A prodrug for quinaprilat hydrochloride (by hydrolysis of the ethyl ester to the corresponding carboxylic acid), it is used as an angiotensin-converting enzyme inhibitor (ACE inhibitor) for the treatment of hypertension and congestive heart failure.
Chemical ID: MESH:C041125
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Agtdecreases activityEXP 6480464CTDQuinapril results in decreased activity of AGT protein

PMID:15728788
Agtmultiple interactionsEXP 6480464CTDQuinapril inhibits the reaction [Isoproterenol results in increased expression of AGT protein] Quinapril promotes the reaction [Isoproterenol results in increased expression of AGT protein]

PMID:11709406
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