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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2069
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Agt
Name: angiotensinogen
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Agtdecreases expressionISOAgt (Mus musculus)6480464CTDProgesterone results in decreased expression of AGT mRNAPMID:22095930
Agtdecreases secretionISOAGT (Homo sapiens)6480464CTDAGT protein results in decreased secretion of ProgesteronePMID:28235592
Agtmultiple interactionsISOAGT (Homo sapiens)6480464CTDProgesterone inhibits the reaction [AGT protein results in increased abundance of Inositol Phosphates]PMID:1337236
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