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GENE - TERM ANNOTATION REPORT

RGD ID: 2069
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Agt
Name: angiotensinogen
Acc ID: DOID:10591
Term: pre-eclampsia
Definition: A hypertension occurring during pregnancy characterized by large amounts of protein in the urine (proteinuria) and edema, usually by the last trimester of pregnancy. (DO)
Definition Source(s): http://en.wikipedia.org/wiki/Pre-eclampsia "DO" "DO", http://ghr.nlm.nih.gov/condition/preeclampsia "DO" "DO", https://www.ncbi.nlm.nih.gov/pubmed/24400024 "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Agt ISOAGT (Homo sapiens)1300394RGDDNA:polymorphism: :p.M235T (human) 
Agt ISOAGT (Homo sapiens)13432363RGD  
Agt ISOAGT (Homo sapiens)11554173CTDCTD Direct Evidence: marker/mechanismPMID:8513325
Agt ISOAGT (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Preeclampsia, susceptibility toPMID:1394429 PMID:16059745 PMID:25741868 PMID:28492532 PMID:7649545 PMID:7883995 PMID:8348146 PMID:8513325 PMID:8518804 PMID:9259580 PMID:9421481 PMID:9831339
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