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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2069
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Agt
Name: angiotensinogen
Acc ID: CHEBI:34157
Term: 14,15-EET
Definition: An EET obtained by formal epoxidation of the 14,15-double bond of arachidonic acid.
Chemical ID: MESH:C046782
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Agtdecreases expressionEXP 6480464CTD14,15-epoxy-5,8,11-eicosatrienoic acid analog results in decreased expression of AGT protein modified formPMID:27428043
Agtincreases cleavageEXP 6480464CTD14,15-epoxy-5,8,11-eicosatrienoic acid analog results in increased cleavage of AGT protein modified formPMID:27428043
Agtmultiple interactionsEXP 6480464CTD[14,15-epoxy-5,8,11-eicosatrienoic acid analog results in increased cleavage of AGT protein modified form] which results in increased abundance of angiotensin I (1-7)PMID:27428043
Agtmultiple interactionsISORGD:101186480464CTD14,15-epoxy-5,8,11-eicosatrienoic acid analog inhibits the reaction [REN2 protein results in increased expression of AGT protein modified form]PMID:27428043
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