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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2069
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Agt
Name: angiotensinogen
Acc ID: CHEBI:3441
Term: carvedilol
Definition: A member of the class of carbazoles that is an adrenergic antagonist with non-selective beta- and alpha-1 receptor blocking properties which helps in the management of congestive heart failure.
Chemical ID: MESH:C043211
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Agtdecreases response to substanceEXP 6480464CTDcarvedilol results in decreased susceptibility to AGT protein modified formPMID:19183357 PMID:21047287 PMID:21166975
Agtmultiple interactionsEXP 6480464CTD[Losartan co-treated with Carvedilol] results in decreased susceptibility to AGT protein modified form; Carvedilol inhibits the reaction [AGT protein affects the localization of RAC1 protein]; Carvedilol inhibits the reaction [AGT protein results in increased abundance of Glycerol]; Carvedilol inhibits the reaction [AGT protein results in increased abundance of Norepinephrine]; Carvedilol inhibits the reaction [AGT protein results in increased abundance of Reactive Oxygen Species]; Carvedilol inhibits the reaction [Losartan results in decreased susceptibility to AGT protein modified form]; Losartan inhibits the reaction [Carvedilol results in decreased susceptibility to AGT protein modified form]PMID:15741261 PMID:16940222 PMID:19183357 PMID:21166975
Agtdecreases expressionISOAGT (Homo sapiens)6480464CTDcarvedilol results in decreased expression of AGT proteinPMID:12004934
Agtdecreases response to substanceISOAGT (Homo sapiens)6480464CTDcarvedilol results in decreased susceptibility to AGT protein modified formPMID:12538430
Agtmultiple interactionsISOAGT (Homo sapiens)6480464CTDcarvedilol inhibits the reaction [AGT protein modified form promotes the reaction [Phenylephrine results in increased abundance of Inositol Phosphates]]; carvedilol inhibits the reaction [AGT protein modified form results in increased susceptibility to Phenylephrine]PMID:16794485
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