Cyp7a1 (cytochrome P450 family 7 subfamily A member 1) - Rat Genome Database

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Gene: Cyp7a1 (cytochrome P450 family 7 subfamily A member 1) Rattus norvegicus
Analyze
Symbol: Cyp7a1
Name: cytochrome P450 family 7 subfamily A member 1
RGD ID: 2482
Description: Enables cholesterol 7-alpha-monooxygenase activity. Involved in several processes, including bile acid biosynthetic process; cellular response to cholesterol; and regulation of lipid biosynthetic process. Located in intracellular membrane-bounded organelle. Biomarker of alcoholic hepatitis; cholestasis; extrahepatic cholestasis; and non-alcoholic steatohepatitis. Orthologous to human CYP7A1 (cytochrome P450 family 7 subfamily A member 1); PARTICIPATES IN bile acid signaling pathway; bile acid biosynthetic pathway; cerebrotendinous xanthomatosis pathway; INTERACTS WITH (+)-schisandrin B; (-)-epigallocatechin 3-gallate; (25R)-cholest-5-ene-3beta,26-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 24-hydroxycholesterol 7-alpha-hydroxylase; CHAP; cholesterol 7 alpha-hydroxylase; cholesterol 7-alpha hydroxylase; cholesterol 7-alpha-hydroxylase; cholesterol 7-alpha-monooxygenase; CYP7; CYP7S1; CYPVII; Cytochrom P450 (cholesterol hydroxylase 7 alpha); cytochrome P450 (cholesterol hydroxylase 7 alpha); cytochrome P450 7A1; cytochrome P450, 7a1; cytochrome P450, family 7, subfamily a, polypeptide 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2519,376,979 - 19,386,676 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl519,376,974 - 19,386,688 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx521,584,097 - 21,593,795 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0523,169,474 - 23,179,158 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0522,949,785 - 22,959,469 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0519,358,734 - 19,368,431 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl519,358,734 - 19,368,431 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0524,143,589 - 24,153,286 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4519,707,159 - 19,716,856 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1519,707,158 - 19,716,856 (-)NCBI
Celera518,677,267 - 18,686,964 (-)NCBICelera
Cytogenetic Map5q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
(1->4)-beta-D-glucan  (ISO)
(24S)-24-hydroxycholesterol  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (EXP,ISO)
(E)-thiamethoxam  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (ISO)
1,3,7,9-tetramethyluric acid  (EXP)
1,4-dithiothreitol  (EXP)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-arachidonoylglycerol  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
20-hydroxycholesterol  (EXP,ISO)
25-hydroxycholesterol  (EXP,ISO)
26-hydroxycholesterol  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
7-ketocholesterol  (EXP)
7alpha-hydroxycholesterol  (EXP)
8-Epidiosbulbin E acetate  (ISO)
acrylamide  (EXP,ISO)
Actein  (EXP)
aflatoxin B1  (ISO)
alfacalcidol  (ISO)
all-trans-retinoic acid  (EXP,ISO)
allopurinol  (ISO)
AM-251  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
amphibole asbestos  (ISO)
amphotericin B  (ISO)
ampicillin  (ISO)
angelicin  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atazanavir sulfate  (ISO)
atorvastatin calcium  (EXP,ISO)
atrazine  (ISO)
Augmentin  (ISO)
azoxystrobin  (ISO)
Benoxacor  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-hexachlorocyclohexane  (ISO)
beta-naphthoflavone  (ISO)
bezafibrate  (EXP,ISO)
bilirubin IXalpha  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bosentan  (ISO)
bromobenzene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcipotriol  (ISO)
calcitriol  (ISO)
carbendazim  (ISO)
carbon nanotube  (ISO)
chenodeoxycholic acid  (EXP,ISO)
chitosan  (EXP)
chlormequat chloride  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
cholate  (ISO)
cholesta-5,7-dien-3beta-ol  (EXP)
cholesterol  (EXP,ISO)
cholic acid  (EXP,ISO)
chrysophanol  (EXP)
ciguatoxin CTX1B  (ISO)
clavulanic acid  (ISO)
clofibrate  (EXP,ISO)
clothianidin  (EXP)
cobalt atom  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
corn oil  (EXP)
coumarin  (EXP)
cyclosporin A  (ISO)
cyproconazole  (EXP,ISO)
cyprodinil  (ISO)
cysteamine  (EXP)
DDE  (ISO)
deoxycholic acid  (EXP,ISO)
dexamethasone  (EXP)
dextran sulfate  (ISO)
diallyl trisulfide  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
difenoconazole  (ISO)
dihydroartemisinin  (EXP)
dihydroxyacetone  (ISO)
Diisodecyl phthalate  (ISO)
dimethomorph  (ISO)
dimethyl sulfoxide  (EXP)
Diosbulbin B  (ISO)
diosgenin  (EXP)
dioxygen  (ISO)
disodium selenite  (ISO)
elemental selenium  (EXP,ISO)
emodin  (EXP)
endosulfan  (EXP,ISO)
enilconazole  (EXP,ISO)
Epomediol  (EXP)
epoxiconazole  (EXP,ISO)
ethambutol  (EXP,ISO)
ethanol  (EXP,ISO)
ethoprophos  (ISO)
fenbuconazole  (ISO)
fenhexamid  (ISO)
fenofibrate  (EXP,ISO)
fenpyroximate  (ISO)
fenvalerate  (EXP)
Fexaramine  (ISO)
fipronil  (ISO)
fisetin  (EXP)
flavonoids  (EXP)
fludioxonil  (ISO)
flusilazole  (ISO)
flutamide  (EXP)
fluxapyroxad  (ISO)
furan  (EXP,ISO)
gemfibrozil  (ISO)
genistein  (EXP)
Gentiopicrin  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glycyrrhizinic acid  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
graphene oxide  (ISO)
guggulsterone  (EXP,ISO)
GW 3965  (EXP)
GW 4064  (EXP,ISO)
Heliotrine  (ISO)
hyperforin  (ISO)
icariside II  (ISO)
imipenem hydrate  (ISO)
indoxyl sulfate  (ISO)
iprodione  (ISO)
isoniazide  (EXP,ISO)
kaempferol  (ISO)
ketoconazole  (EXP,ISO)
kojic acid  (ISO)
L-1,4-dithiothreitol  (EXP)
L-ascorbic acid  (ISO)
Lasiocarpine  (ISO)
lead nitrate  (EXP,ISO)
lead(0)  (EXP)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (EXP,ISO)
loperamide  (ISO)
magnesium atom  (EXP)
maneb  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
melatonin  (ISO)
mercaptoethanol  (EXP)
mercury atom  (EXP)
mercury(0)  (EXP)
metacetamol  (ISO)
metalaxyl  (ISO)
metformin  (EXP,ISO)
methapyrilene  (EXP)
methotrexate  (EXP,ISO)
methoxsalen  (EXP,ISO)
methoxychlor  (EXP)
metronidazole  (ISO)
monocrotaline  (ISO)
monocrotophos  (EXP)
monosodium L-glutamate  (ISO)
Muraglitazar  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (ISO)
neomycin  (ISO)
nickel atom  (ISO)
nitrofen  (EXP)
O-methyleugenol  (ISO)
obeticholic acid  (EXP,ISO)
okadaic acid  (ISO)
oleanolic acid  (ISO)
oleic acid  (EXP)
orphenadrine  (EXP)
oxybenzone  (EXP)
p-chloromercuribenzoic acid  (EXP)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
parathion  (ISO)
pentachlorophenol  (ISO)
perflubutane  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorobutyric acid  (EXP)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanesulfonamide  (ISO)
perfluorooctanoic acid  (ISO)
perfluoropentanoic acid  (ISO)
perfluoroundecanoic acid  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidylcholine  (EXP)
pioglitazone  (ISO)
pirinixic acid  (ISO)
pregnenolone  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
prochloraz  (ISO)
procymidone  (ISO)
propiconazole  (ISO)
prothioconazole  (ISO)
Prothioconazole-desthio  (ISO)
psoralen  (EXP)
puerarin  (EXP)
PX-866  (ISO)
pyrazinecarboxamide  (EXP,ISO)
pyrrolidines  (EXP)
resveratrol  (EXP,ISO)
rifampicin  (EXP,ISO)
rifaximin  (ISO)
ritonavir  (EXP,ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Salidroside  (ISO)
saracatinib  (ISO)
selenium atom  (EXP,ISO)
senecionine  (EXP,ISO)
Senkirkine  (ISO)
sevoflurane  (EXP)
simvastatin  (EXP)
sodium arsenite  (ISO)
sodium cholate  (ISO)
sodium dichromate  (EXP)
soybean oil  (EXP)
spironolactone  (EXP)
streptozocin  (EXP,ISO)
sulfluramid  (ISO)
sulforaphane  (ISO)
Sunset Yellow FCF  (ISO)
tamoxifen  (EXP,ISO)
tartrazine  (ISO)
taurocholic acid  (EXP,ISO)
tebuconazole  (ISO)
tectorigenin  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP,ISO)
thiacloprid  (EXP,ISO)
thiamethoxam  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP,ISO)
triclosan  (ISO)
triphenyl phosphate  (EXP,ISO)
Triptolide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
trovafloxacin  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP,ISO)
usnic acid  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
Yangonin  (ISO)
zinc atom  (EXP,ISO)
zinc pyrithione  (ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Regulation of cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRalpha). Chiang JY, etal., Gene 2001 Jan 10;262(1-2):257-65.
2. The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis. Fiorucci S, etal., Gastroenterology. 2004 Nov;127(5):1497-512. doi: 10.1053/j.gastro.2004.08.001.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Down-regulation of cholesterol 7alpha-hydroxylase (CYP7A1) gene expression by bile acids in primary rat hepatocytes is mediated by the c-Jun N-terminal kinase pathway. Gupta S, etal., J Biol Chem 2001 May 11;276(19):15816-22.
6. Exploration of Hepatoprotective Effect of Gentiopicroside on Alpha-Naphthylisothiocyanate-Induced Cholestatic Liver Injury in Rats by Comprehensive Proteomic and Metabolomic Signatures. Han H, etal., Cell Physiol Biochem. 2018;49(4):1304-1319. doi: 10.1159/000493409. Epub 2018 Sep 17.
7. Farnesoid X receptor agonist INT-767 attenuates liver steatosis and inflammation in rat model of nonalcoholic steatohepatitis. Hu YB, etal., Drug Des Devel Ther. 2018 Jul 16;12:2213-2221. doi: 10.2147/DDDT.S170518. eCollection 2018.
8. Alisma orientale extract exerts the reversing cholestasis effect by activation of farnesoid X receptor. Huo XK, etal., Phytomedicine. 2018 Mar 15;42:34-42. doi: 10.1016/j.phymed.2018.03.017. Epub 2018 Mar 8.
9. Structure of the rat gene encoding cholesterol 7 alpha-hydroxylase. Jelinek DF and Russell DW, Biochemistry 1990 Aug 28;29(34):7781-5.
10. Cloning and regulation of cholesterol 7 alpha-hydroxylase, the rate-limiting enzyme in bile acid biosynthesis. Jelinek DF, etal., J Biol Chem 1990 May 15;265(14):8190-7.
11. Suppressed hepatic bile acid signalling despite elevated production of primary and secondary bile acids in NAFLD. Jiao N, etal., Gut. 2018 Oct;67(10):1881-1891. doi: 10.1136/gutjnl-2017-314307. Epub 2017 Aug 3.
12. ARP-1/COUP-TF II determines hepatoma phenotype by acting as both a transcriptional repressor of microsomal triglyceride transfer protein and an inducer of CYP7A1. Kang S, etal., J Biol Chem 2003 Aug 15;278(33):30478-86. Epub 2003 May 30.
13. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
14. Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. Lehmann JM, etal., J Biol Chem 1997 Feb 7;272(6):3137-40.
15. Regulation of cholesterol and bile acid homeostasis by the cholesterol 7a-hydroxylase/steroid response element-binding protein 2/microRNA-33a axis in mice. Li T, etal., Hepatology. 2013 Sep;58(3):1111-21. doi: 10.1002/hep.26427. Epub 2013 Jul 31.
16. Regulation of cholesterol 7 alpha-hydroxylase in the liver. Cloning, sequencing, and regulation of cholesterol 7 alpha-hydroxylase mRNA. Li YC, etal., J Biol Chem 1990 Jul 15;265(20):12012-9.
17. Bile acid biosynthesis during liver regeneration: enzyme activities of cholesterol 7alpha-hydroxylase and 3beta-hydroxy-delta5-C27-steroid dehydrogenase in rats. Maeda Y, etal., Ann Clin Lab Sci. 2005 Summer;35(3):323-8.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. Structural analysis of the gene encoding rat cholesterol alpha-hydroxylase, the key enzyme for bile acid biosynthesis. Nishimoto M, etal., J Biol Chem 1991 Apr 5;266(10):6467-71.
21. Rat liver cholesterol 7 alpha-hydroxylase. Pretranslational regulation for circadian rhythm. Noshiro M, etal., J Biol Chem 1990 Jun 15;265(17):10036-41.
22. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
23. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
24. GOA pipeline RGD automated data pipeline
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Increased hepatic ABCA1 transporter is associated with hypercholesterolemia in a cholestatic rat model and primary biliary cholangitis patients. Takeyama Y, etal., Med Mol Morphol. 2017 Dec;50(4):227-237. doi: 10.1007/s00795-017-0166-7. Epub 2017 Jun 28.
28. Dihydroartemisinin protects against alcoholic liver injury through alleviating hepatocyte steatosis in a farnesoid X receptor-dependent manner. Xu W, etal., Toxicol Appl Pharmacol. 2017 Jan 15;315:23-34. doi: 10.1016/j.taap.2016.12.001. Epub 2016 Dec 6.
29. Puerarin decreases serum total cholesterol and enhances thoracic aorta endothelial nitric oxide synthase expression in diet-induced hypercholesterolemic rats. Yan LP, etal., Life Sci. 2006 Jun 20;79(4):324-30. doi: 10.1016/j.lfs.2006.01.016. Epub 2006 Feb 10.
30. Modulation of transport and metabolism of bile acids and bilirubin by chlorogenic acid against hepatotoxicity and cholestasis in bile duct ligation rats: involvement of SIRT1-mediated deacetylation of FXR and PGC-1α. Zhu L, etal., J Hepatobiliary Pancreat Sci. 2018 Mar;25(3):195-205. doi: 10.1002/jhbp.537.
Additional References at PubMed
PMID:1420318   PMID:2806567   PMID:8021257   PMID:11279518   PMID:12054605   PMID:12077124   PMID:12114517   PMID:12223476   PMID:12554795   PMID:15845870   PMID:18226361   PMID:18292185  
PMID:18578998   PMID:18696335   PMID:19788618   PMID:19957370   PMID:19965590   PMID:20215401   PMID:20362056   PMID:21147774   PMID:21372147   PMID:21817852   PMID:23108811   PMID:23146761  
PMID:23617777   PMID:23852734   PMID:26475369   PMID:26663205   PMID:27133208   PMID:29028359   PMID:31288013  


Genomics

Comparative Map Data
Cyp7a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2519,376,979 - 19,386,676 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl519,376,974 - 19,386,688 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx521,584,097 - 21,593,795 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0523,169,474 - 23,179,158 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0522,949,785 - 22,959,469 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0519,358,734 - 19,368,431 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl519,358,734 - 19,368,431 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0524,143,589 - 24,153,286 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4519,707,159 - 19,716,856 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1519,707,158 - 19,716,856 (-)NCBI
Celera518,677,267 - 18,686,964 (-)NCBICelera
Cytogenetic Map5q12NCBI
CYP7A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38858,490,178 - 58,500,163 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl858,490,178 - 58,500,163 (-)EnsemblGRCh38hg38GRCh38
GRCh37859,402,737 - 59,412,722 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36859,565,292 - 59,575,275 (-)NCBINCBI36Build 36hg18NCBI36
Build 34859,565,291 - 59,575,275NCBI
Celera855,395,751 - 55,405,734 (-)NCBICelera
Cytogenetic Map8q12.1NCBI
HuRef854,889,962 - 54,899,885 (-)NCBIHuRef
CHM1_1859,454,626 - 59,464,609 (-)NCBICHM1_1
T2T-CHM13v2.0858,911,316 - 58,921,301 (-)NCBIT2T-CHM13v2.0
Cyp7a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3946,265,612 - 6,275,632 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl46,265,612 - 6,275,633 (-)EnsemblGRCm39 Ensembl
GRCm3846,265,612 - 6,275,632 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl46,265,612 - 6,275,633 (-)EnsemblGRCm38mm10GRCm38
MGSCv3746,192,759 - 6,202,778 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3646,192,759 - 6,202,778 (-)NCBIMGSCv36mm8
Celera46,185,007 - 6,195,027 (-)NCBICelera
Cytogenetic Map4A1NCBI
cM Map42.91NCBI
LOC102008593
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545417,036,204 - 17,042,756 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545417,035,105 - 17,078,854 (-)NCBIChiLan1.0ChiLan1.0
CYP7A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1849,837,992 - 49,847,979 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0854,942,509 - 54,952,500 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1856,593,799 - 56,603,933 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl856,593,799 - 56,604,037 (-)Ensemblpanpan1.1panPan2
CYP7A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1299,285,315 - 9,295,895 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl299,286,181 - 9,332,310 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha299,598,242 - 9,625,248 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0299,370,713 - 9,397,915 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl299,371,580 - 9,417,428 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1299,368,643 - 9,395,863 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0299,494,537 - 9,521,733 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0299,773,555 - 9,801,001 (-)NCBIUU_Cfam_GSD_1.0
LOC101970910
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530370,179,849 - 70,187,118 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364964,599,138 - 4,605,653 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049364964,599,138 - 4,605,653 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP7A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl474,343,123 - 74,372,621 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1474,343,101 - 74,372,628 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2481,137,378 - 81,166,790 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CYP7A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1854,475,801 - 54,489,329 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl854,477,105 - 54,485,649 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603987,237,971 - 87,247,876 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101701685
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474433,612,901 - 33,619,869 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474433,563,564 - 33,619,851 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cyp7a1
63 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:515
Count of miRNA genes:248
Interacting mature miRNAs:315
Transcripts:ENSRNOT00000012819
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
2312562Pur18Proteinuria QTL 182.60.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)5213896532656739Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
2313085Bss59Bone structure and strength QTL 592.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)5384401826141981Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5384401847869213Rat
61462Niddm10Non-insulin dependent diabetes mellitus QTL 103.90.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)5511215947171491Rat
2293666Bmd38Bone mineral density QTL 384.4femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)5894822853948228Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51268928557689285Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51887394763873947Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51887394774251464Rat

Markers in Region
D5Wox31  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2519,388,134 - 19,388,390 (+)MAPPERmRatBN7.2
Rnor_6.0519,369,890 - 19,370,145NCBIRnor6.0
Rnor_5.0524,154,745 - 24,155,000UniSTSRnor5.0
RGSC_v3.4519,718,315 - 19,718,570UniSTSRGSC3.4
Celera518,688,423 - 18,688,678UniSTS
Cytogenetic Map5q12UniSTS
PMC165443P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2519,383,568 - 19,383,689 (+)MAPPERmRatBN7.2
Rnor_6.0519,365,324 - 19,365,444NCBIRnor6.0
Rnor_5.0524,150,179 - 24,150,299UniSTSRnor5.0
RGSC_v3.4519,713,749 - 19,713,869UniSTSRGSC3.4
Celera518,683,857 - 18,683,977UniSTS
Cytogenetic Map5q12UniSTS
RH141579  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2519,378,660 - 19,378,879 (+)MAPPERmRatBN7.2
Rnor_6.0519,360,416 - 19,360,634NCBIRnor6.0
Rnor_5.0524,145,271 - 24,145,489UniSTSRnor5.0
RGSC_v3.4519,708,841 - 19,709,059UniSTSRGSC3.4
Celera518,678,949 - 18,679,167UniSTS
RH 3.4 Map586.8UniSTS
Cytogenetic Map5q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 20 20 20
Low 12 11 11 5 2
Below cutoff 4 17 4 9 4 6 6 5 8 23 4 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000012819   ⟹   ENSRNOP00000012819
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl519,376,974 - 19,386,688 (-)Ensembl
Rnor_6.0 Ensembl519,358,734 - 19,368,431 (-)Ensembl
RefSeq Acc Id: NM_012942   ⟹   NP_037074
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2519,376,979 - 19,386,676 (-)NCBI
Rnor_6.0519,358,734 - 19,368,431 (-)NCBI
Rnor_5.0524,143,589 - 24,153,286 (-)NCBI
RGSC_v3.4519,707,159 - 19,716,856 (-)RGD
Celera518,677,267 - 18,686,964 (-)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_037074   ⟸   NM_012942
- UniProtKB: P51543 (UniProtKB/Swiss-Prot),   P18125 (UniProtKB/Swiss-Prot),   A6JFN9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000012819   ⟸   ENSRNOT00000012819

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P18125-F1-model_v2 AlphaFold P18125 1-503 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2482 AgrOrtholog
BioCyc Gene G2FUF-42081 BioCyc
BioCyc Pathway PWY-6061 [bile acid biosynthesis, neutral pathway] BioCyc
Ensembl Genes ENSRNOG00000009488 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000012819 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000012819 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cholesterol_7a_monooxygenase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CYP7A1-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-IV UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25428 UniProtKB/Swiss-Prot
NCBI Gene 25428 ENTREZGENE
PANTHER CYTOCHROME P450 7A1 UniProtKB/TrEMBL
  CYTOCHROME P450 FAMILY 7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24304:SF1 UniProtKB/Swiss-Prot
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CYP7A1 RGD
PhenoGen Cyp7a1 PhenoGen
PIRSF Cytochrome_CYP7A1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cytochrome_CYPVIIA1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS EP450IV UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Cytochrome P450 UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6JFN9 ENTREZGENE, UniProtKB/TrEMBL
  CP7A1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  P51543 ENTREZGENE
UniProt Secondary P51543 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-06-13 Cyp7a1  cytochrome P450 family 7 subfamily A member 1  Cyp7a1  cytochrome P450, family 7, subfamily a, polypeptide 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Cyp7a1  cytochrome P450, family 7, subfamily a, polypeptide 1    cytochrome P450, 7a1  Name updated 625702 APPROVED
2002-06-10 Cyp7a1  cytochrome P450, 7a1      Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression present in the liver 70535
gene_function rate-limiting enzyme in bile acid biosynthesis neutral pathway 68679
gene_process regulates the cholesterol supply pathways 70536
gene_process regulates bile acid biosynthesis and cholesterol homeostasis 68679
gene_process regulates bile acid biosynthesis and cholesterol homeostasis 70535
gene_product 503 amino acid protein 70535
gene_product member of the cytochrome P-450 enzyme family 70535
gene_regulation promoter activity repressed by activated FXR/RXR heterodimer 68679
gene_regulation cholestyramine treatment caused 2-3 fold increase in the mRNA proving cholesterol is an important regulator 70534
gene_regulation transcription down regulated by bile acids via activation of the JNK/c-Jun pathway 68679
gene_transcript cDNA contains 3561 bp and a poly(A) tail of 65 A residues 70534
gene_transcript cDNA contains 3561 bp and a poly(A) tail of 65 A residues 70535
gene_transcript has LXR alpha and LXR beta nuclear receptors in the promoter region 70536