Cyp7a1 (cytochrome P450 family 7 subfamily A member 1) - Rat Genome Database

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Gene: Cyp7a1 (cytochrome P450 family 7 subfamily A member 1) Rattus norvegicus
Analyze
Symbol: Cyp7a1
Name: cytochrome P450 family 7 subfamily A member 1
RGD ID: 2482
Description: Enables cholesterol 7-alpha-monooxygenase activity. Involved in several processes, including cellular response to cholesterol; regulation of lipid biosynthetic process; and steroid metabolic process. Located in intracellular membrane-bounded organelle. Biomarker of alcoholic hepatitis; cholestasis; extrahepatic cholestasis; and metabolic dysfunction-associated steatohepatitis. Orthologous to human CYP7A1 (cytochrome P450 family 7 subfamily A member 1); PARTICIPATES IN bile acid biosynthetic pathway; bile acid signaling pathway; cerebrotendinous xanthomatosis pathway; INTERACTS WITH (+)-schisandrin B; (-)-epigallocatechin 3-gallate; (25R)-cholest-5-ene-3beta,26-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 24-hydroxycholesterol 7-alpha-hydroxylase; CHAP; cholesterol 7 alpha-hydroxylase; cholesterol 7-alpha hydroxylase; cholesterol 7-alpha-hydroxylase; cholesterol 7-alpha-monooxygenase; CYP7; CYP7S1; CYPVII; Cytochrom P450 (cholesterol hydroxylase 7 alpha); cytochrome P450 (cholesterol hydroxylase 7 alpha); cytochrome P450 7A1; cytochrome P450, 7a1; cytochrome P450, family 7, subfamily a, polypeptide 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8524,174,505 - 24,184,202 (-)NCBIGRCr8
mRatBN7.2519,376,979 - 19,386,676 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl519,376,974 - 19,386,688 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx521,584,097 - 21,593,795 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0523,169,474 - 23,179,158 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0522,949,785 - 22,959,469 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0519,358,734 - 19,368,431 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl519,358,734 - 19,368,431 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0524,143,589 - 24,153,286 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4519,707,159 - 19,716,856 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1519,707,158 - 19,716,856 (-)NCBI
Celera518,677,267 - 18,686,964 (-)NCBICelera
Cytogenetic Map5q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
Cyp7a1Ratalcoholic hepatitis treatmentIEP 15036816 RGD 
Cyp7a1Ratcholestasis treatmentIEP 15090803 RGD 
Cyp7a1RatExperimental Liver Cirrhosis treatmentIMP 15045602 RGD 
Cyp7a1Ratextrahepatic cholestasis  IEP 21203516mRNA:decreased expression:liver and nucleus (rat)RGD 
Cyp7a1Ratextrahepatic cholestasis treatmentIEP 14995480mRNA:decreased expression:liver (rat)RGD 
Cyp7a1RatHypercholesterolemia  IEP 13782194mRNA:decreased expression:liverRGD 
Cyp7a1Ratmetabolic dysfunction-associated steatohepatitis  ISOCYP7A1 (Homo sapiens)15045601mRNA:increased expression:liver (human)RGD 
Cyp7a1Ratmetabolic dysfunction-associated steatohepatitis treatmentIEP 15092090mRNA and protein:altered expression:liver (rat) treatment with INT-767RGD 
Cyp7a1RatMetabolic Syndrome amelioratesISOCyp7a1 (Mus musculus)401850595 RGD 
1 to 9 of 9 rows
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Original Reference(s)
Cyp7a1Ratautism spectrum disorder  ISOCYP7A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:35663546
Cyp7a1Ratcholestasis  ISOCYP7A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:9797378 and PMID:22461449
Cyp7a1RatHypercholesterolemia  ISOCYP7A1 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:8245718

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Original Reference(s)
Cyp7a1Rat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP7A1 mRNA]CTDPMID:31150632
Cyp7a1Rat(-)-epigallocatechin 3-gallate increases expressionEXP 6480464epigallocatechin gallate results in increased expression of CYP7A1 mRNA and epigallocatechin gallate results in increased expression of CYP7A1 proteinCTDPMID:23146761
Cyp7a1Rat(1->4)-beta-D-glucan multiple interactionsISOCyp7a1 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of CYP7A1 mRNACTDPMID:36331819
Cyp7a1Rat(24S)-24-hydroxycholesterol increases metabolic processingISOCYP7A1 (Homo sapiens)6480464CYP7A1 protein results in increased metabolism of 24-hydroxycholesterolCTDPMID:11013305
Cyp7a1Rat(25R)-cholest-5-ene-3beta,26-diol increases metabolic processingEXP 6480464CYP7A1 protein results in increased metabolism of 27-hydroxycholesterolCTDPMID:10882719
Cyp7a1Rat(25R)-cholest-5-ene-3beta,26-diol increases metabolic processingISOCYP7A1 (Homo sapiens)6480464CYP7A1 protein results in increased metabolism of 27-hydroxycholesterolCTDPMID:10882719
Cyp7a1Rat(E)-thiamethoxam decreases expressionISOCYP7A1 (Homo sapiens)6480464Thiamethoxam results in decreased expression of CYP7A1 proteinCTDPMID:32194361
Cyp7a1Rat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane affects expressionISOCyp7a1 (Mus musculus)6480464o and p'-DDT affects the expression of CYP7A1 mRNACTDPMID:18925944
Cyp7a1Rat1,2-dichloroethane decreases expressionISOCyp7a1 (Mus musculus)6480464ethylene dichloride results in decreased expression of CYP7A1 mRNACTDPMID:28189721 and PMID:28960355
Cyp7a1Rat1,3,4-thiadiazole affects expressionEXP 64804641 more ...CTDPMID:30905023
Cyp7a1Rat1,3,7,9-tetramethyluric acid multiple interactionsEXP 64804641 more ...CTDPMID:35872049
Cyp7a1Rat1,4-dithiothreitol increases activityEXP 6480464Dithiothreitol results in increased activity of CYP7A1 proteinCTDPMID:1175606
Cyp7a1Rat1-naphthyl isothiocyanate decreases expressionEXP 64804641-Naphthylisothiocyanate results in decreased expression of CYP7A1 mRNA and 1-Naphthylisothiocyanate results in decreased expression of CYP7A1 proteinCTDPMID:14623915 more ...
Cyp7a1Rat1-naphthyl isothiocyanate increases expressionISOCyp7a1 (Mus musculus)64804641-Naphthylisothiocyanate results in increased expression of CYP7A1 proteinCTDPMID:36787806
Cyp7a1Rat1-naphthyl isothiocyanate multiple interactionsISOCYP7A1 (Homo sapiens)64804644-methyl-7 and 8-dihydroxycoumarin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CYP7A1 protein]CTDPMID:36581201
Cyp7a1Rat1-naphthyl isothiocyanate increases expressionISOCYP7A1 (Homo sapiens)64804641-Naphthylisothiocyanate results in increased expression of CYP7A1 proteinCTDPMID:36581201
Cyp7a1Rat1-naphthyl isothiocyanate decreases expressionEXP 150908031-naphthyl isothiocyanate decreases expression of Cyp7a1 protein in rat liverRGD 
Cyp7a1Rat1-naphthyl isothiocyanate increases expressionEXP 64804641-Naphthylisothiocyanate results in increased expression of CYP7A1 mRNACTDPMID:20551477 more ...
Cyp7a1Rat1-naphthyl isothiocyanate decreases expressionISOCyp7a1 (Mus musculus)64804641-Naphthylisothiocyanate results in decreased expression of CYP7A1 mRNA and 1-Naphthylisothiocyanate results in decreased expression of CYP7A1 proteinCTDPMID:25655198 more ...
Cyp7a1Rat1-naphthyl isothiocyanate multiple interactionsISOCyp7a1 (Mus musculus)648046418alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP7A1 mRNA] more ...CTDPMID:25655198 more ...

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Biological Process
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Original Reference(s)
Cyp7a1Ratbile acid biosynthetic process  TAS 70535 RGD 
Cyp7a1Ratbile acid biosynthetic process involved_inIEAInterPro:IPR0306811600115GO_REF:0000002InterProGO_REF:0000002
Cyp7a1Ratbile acid biosynthetic process involved_inIEAUniProtKB:P22680 and ensembl:ENSP000003016451600115GO_REF:0000107EnsemblGO_REF:0000107
Cyp7a1Ratbile acid biosynthetic process involved_inIBAMGI:104978 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cyp7a1Ratbile acid biosynthetic process involved_inISOCYP7A1 (Homo sapiens)1624291 PMID:19965590RGDPMID:19965590
Cyp7a1Ratbile acid biosynthetic process involved_inIEAUniPathway:UPA002211600115GO_REF:0000041UniProtGO_REF:0000041
Cyp7a1Ratbile acid biosynthetic process involved_inIDA 70534PMID:1694852UniProt 
Cyp7a1Ratcellular response to cholesterol involved_inIDA 70534PMID:1694852UniProt 
Cyp7a1Ratcellular response to glucose stimulus involved_inISSUniProtKB:P226801600115GO_REF:0000024UniProtGO_REF:0000024
Cyp7a1Ratcellular response to glucose stimulus involved_inIEAInterPro:IPR0306811600115GO_REF:0000002InterProGO_REF:0000002
Cyp7a1Ratcellular response to glucose stimulus involved_inIEAUniProtKB:P22680 and ensembl:ENSP000003016451600115GO_REF:0000107EnsemblGO_REF:0000107
Cyp7a1Ratcellular response to glucose stimulus involved_inISOCYP7A1 (Homo sapiens)1624291 PMID:19965590RGDPMID:19965590
Cyp7a1Ratcholesterol catabolic process involved_inIEAUniPathway:UPA010581600115GO_REF:0000041UniProtGO_REF:0000041
Cyp7a1Ratcholesterol catabolic process acts_upstream_of_or_withinIEAUniProtKB:Q64505 and ensembl:ENSMUSP000000299051600115GO_REF:0000107EnsemblGO_REF:0000107
Cyp7a1Ratcholesterol catabolic process acts_upstream_of_or_withinISOCyp7a1 (Mus musculus)1624291 PMID:11279518 and PMID:15845870RGDPMID:11279518 and PMID:15845870
Cyp7a1Ratcholesterol catabolic process involved_inIEAInterPro:IPR0306811600115GO_REF:0000002InterProGO_REF:0000002
Cyp7a1Ratcholesterol catabolic process involved_inIDA 70534PMID:1694852UniProt 
Cyp7a1Ratcholesterol homeostasis involved_inIDA 70534PMID:1694852UniProt 
Cyp7a1Ratcholesterol homeostasis involved_inIBAPANTHER:PTN001548757 and Cyp7a1 (Rattus norvegicus)1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cyp7a1Ratcholesterol homeostasis involved_inIEAInterPro:IPR0306811600115GO_REF:0000002InterProGO_REF:0000002
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Cellular Component

  
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Original Reference(s)
Cyp7a1Ratendoplasmic reticulum located_inIEAUniProtKB-KW:KW-02561600115GO_REF:0000043UniProtGO_REF:0000043
Cyp7a1Ratendoplasmic reticulum membrane located_inIEAUniProtKB-SubCell:SL-00971600115GO_REF:0000044UniProtGO_REF:0000044
Cyp7a1Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043

Molecular Function
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Original Reference(s)
Cyp7a1Rat24S-hydroxycholesterol 7-alpha-hydroxylase activity enablesIEAEC:1.14.14.261600115GO_REF:0000003UniProtGO_REF:0000003
Cyp7a1Rat24S-hydroxycholesterol 7-alpha-hydroxylase activity enablesIEARHEA:461241600115GO_REF:0000116RHEAGO_REF:0000116
Cyp7a1Ratcholesterol 7-alpha-monooxygenase activity  IDA 70535 RGD 
Cyp7a1Ratcholesterol 7-alpha-monooxygenase activity enablesIEAUniProtKB:P22680 and ensembl:ENSP000003016451600115GO_REF:0000107EnsemblGO_REF:0000107
Cyp7a1Ratcholesterol 7-alpha-monooxygenase activity enablesIEAInterPro:IPR0306811600115GO_REF:0000002InterProGO_REF:0000002
Cyp7a1Ratcholesterol 7-alpha-monooxygenase activity enablesIEAEC:1.14.14.231600115GO_REF:0000003UniProtGO_REF:0000003
Cyp7a1Ratcholesterol 7-alpha-monooxygenase activity enablesIEARHEA:218121600115GO_REF:0000116RHEAGO_REF:0000116
Cyp7a1Ratcholesterol 7-alpha-monooxygenase activity enablesISOCyp7a1 (Mus musculus)1624291 PMID:11279518 more ...RGDPMID:11279518 more ...
Cyp7a1Ratcholesterol 7-alpha-monooxygenase activity enablesIBAMGI:106091 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cyp7a1Ratcholesterol 7-alpha-monooxygenase activity enablesIEAUniProtKB:Q64505 and ensembl:ENSMUSP000000299051600115GO_REF:0000107EnsemblGO_REF:0000107
Cyp7a1Ratcholesterol 7-alpha-monooxygenase activity enablesISOCYP7A1 (Homo sapiens)1624291 PMID:12077124RGDPMID:12077124
Cyp7a1Ratcholesterol 7-alpha-monooxygenase activity enablesIDA 70534PMID:1694852UniProt 
Cyp7a1Ratheme binding enablesIEAInterPro:IPR001128 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Cyp7a1Ratiron ion binding enablesIEAInterPro:IPR001128 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Cyp7a1Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Cyp7a1Ratmonooxygenase activity enablesIEAUniProtKB-KW:KW-05031600115GO_REF:0000043UniProtGO_REF:0000043
Cyp7a1Ratmonooxygenase activity enablesIEAInterPro:IPR001128 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Cyp7a1Ratoxidoreductase activity enablesIEAUniProtKB-KW:KW-05601600115GO_REF:0000043UniProtGO_REF:0000043
Cyp7a1Ratoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen enablesIEAInterPro:IPR001128 more ...1600115GO_REF:0000002InterProGO_REF:0000002
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RGD Manual Annotations


  
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Original Reference(s)
Cyp7a1Ratbile acid signaling pathway  ISOCYP7A1 (Homo sapiens)15045601 RGD 

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

Object Symbol
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Original Reference(s)
Cyp7a1Ratbile acid biosynthetic pathway  IEA 6907045 KEGGrno:00120
Cyp7a1Ratbile acid transport pathway  IEA 6907045 KEGGrno:04976
Cyp7a1Rateicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma  IEA 6907045 KEGGrno:03320
Cyp7a1Ratprimary bile acid biosynthetic pathway  IEA 6907045 KEGGrno:00120
Cyp7a1Ratsteroid hormone biosynthetic pathway   IEA 6907045 KEGGrno:00140

1 to 20 of 31 rows
#
Reference Title
Reference Citation
1. Regulation of cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRalpha). Chiang JY, etal., Gene 2001 Jan 10;262(1-2):257-65.
2. The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis. Fiorucci S, etal., Gastroenterology. 2004 Nov;127(5):1497-512. doi: 10.1053/j.gastro.2004.08.001.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Down-regulation of cholesterol 7alpha-hydroxylase (CYP7A1) gene expression by bile acids in primary rat hepatocytes is mediated by the c-Jun N-terminal kinase pathway. Gupta S, etal., J Biol Chem 2001 May 11;276(19):15816-22.
6. Exploration of Hepatoprotective Effect of Gentiopicroside on Alpha-Naphthylisothiocyanate-Induced Cholestatic Liver Injury in Rats by Comprehensive Proteomic and Metabolomic Signatures. Han H, etal., Cell Physiol Biochem. 2018;49(4):1304-1319. doi: 10.1159/000493409. Epub 2018 Sep 17.
7. Pre-germinated brown rice extract ameliorates high-fat diet-induced metabolic syndrome. Hao CL, etal., J Food Biochem. 2019 Mar;43(3):e12769. doi: 10.1111/jfbc.12769. Epub 2019 Jan 13.
8. Farnesoid X receptor agonist INT-767 attenuates liver steatosis and inflammation in rat model of nonalcoholic steatohepatitis. Hu YB, etal., Drug Des Devel Ther. 2018 Jul 16;12:2213-2221. doi: 10.2147/DDDT.S170518. eCollection 2018.
9. Alisma orientale extract exerts the reversing cholestasis effect by activation of farnesoid X receptor. Huo XK, etal., Phytomedicine. 2018 Mar 15;42:34-42. doi: 10.1016/j.phymed.2018.03.017. Epub 2018 Mar 8.
10. Structure of the rat gene encoding cholesterol 7 alpha-hydroxylase. Jelinek DF and Russell DW, Biochemistry 1990 Aug 28;29(34):7781-5.
11. Cloning and regulation of cholesterol 7 alpha-hydroxylase, the rate-limiting enzyme in bile acid biosynthesis. Jelinek DF, etal., J Biol Chem 1990 May 15;265(14):8190-7.
12. Suppressed hepatic bile acid signalling despite elevated production of primary and secondary bile acids in NAFLD. Jiao N, etal., Gut. 2018 Oct;67(10):1881-1891. doi: 10.1136/gutjnl-2017-314307. Epub 2017 Aug 3.
13. ARP-1/COUP-TF II determines hepatoma phenotype by acting as both a transcriptional repressor of microsomal triglyceride transfer protein and an inducer of CYP7A1. Kang S, etal., J Biol Chem 2003 Aug 15;278(33):30478-86. Epub 2003 May 30.
14. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
15. Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. Lehmann JM, etal., J Biol Chem 1997 Feb 7;272(6):3137-40.
16. Regulation of cholesterol and bile acid homeostasis by the cholesterol 7a-hydroxylase/steroid response element-binding protein 2/microRNA-33a axis in mice. Li T, etal., Hepatology. 2013 Sep;58(3):1111-21. doi: 10.1002/hep.26427. Epub 2013 Jul 31.
17. Regulation of cholesterol 7 alpha-hydroxylase in the liver. Cloning, sequencing, and regulation of cholesterol 7 alpha-hydroxylase mRNA. Li YC, etal., J Biol Chem 1990 Jul 15;265(20):12012-9.
18. Bile acid biosynthesis during liver regeneration: enzyme activities of cholesterol 7alpha-hydroxylase and 3beta-hydroxy-delta5-C27-steroid dehydrogenase in rats. Maeda Y, etal., Ann Clin Lab Sci. 2005 Summer;35(3):323-8.
19. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
1 to 20 of 31 rows
PMID:1420318   PMID:2806567   PMID:8021257   PMID:11279518   PMID:12054605   PMID:12077124   PMID:12114517   PMID:12223476   PMID:12554795   PMID:15845870   PMID:18226361   PMID:18292185  
PMID:18578998   PMID:18696335   PMID:19788618   PMID:19957370   PMID:19965590   PMID:20215401   PMID:20362056   PMID:21147774   PMID:21372147   PMID:21817852   PMID:23108811   PMID:23146761  
PMID:23617777   PMID:23852734   PMID:26475369   PMID:26663205   PMID:27133208   PMID:29028359   PMID:31288013  



Cyp7a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8524,174,505 - 24,184,202 (-)NCBIGRCr8
mRatBN7.2519,376,979 - 19,386,676 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl519,376,974 - 19,386,688 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx521,584,097 - 21,593,795 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0523,169,474 - 23,179,158 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0522,949,785 - 22,959,469 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0519,358,734 - 19,368,431 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl519,358,734 - 19,368,431 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0524,143,589 - 24,153,286 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4519,707,159 - 19,716,856 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1519,707,158 - 19,716,856 (-)NCBI
Celera518,677,267 - 18,686,964 (-)NCBICelera
Cytogenetic Map5q12NCBI
CYP7A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38858,490,178 - 58,500,163 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl858,490,178 - 58,500,163 (-)EnsemblGRCh38hg38GRCh38
GRCh37859,402,737 - 59,412,722 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36859,565,292 - 59,575,275 (-)NCBINCBI36Build 36hg18NCBI36
Build 34859,565,291 - 59,575,275NCBI
Celera855,395,751 - 55,405,734 (-)NCBICelera
Cytogenetic Map8q12.1NCBI
HuRef854,889,962 - 54,899,885 (-)NCBIHuRef
CHM1_1859,454,626 - 59,464,609 (-)NCBICHM1_1
T2T-CHM13v2.0858,911,316 - 58,921,301 (-)NCBIT2T-CHM13v2.0
Cyp7a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3946,265,612 - 6,275,632 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl46,265,612 - 6,275,633 (-)EnsemblGRCm39 Ensembl
GRCm3846,265,612 - 6,275,632 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl46,265,612 - 6,275,633 (-)EnsemblGRCm38mm10GRCm38
MGSCv3746,192,759 - 6,202,778 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3646,192,759 - 6,202,778 (-)NCBIMGSCv36mm8
Celera46,185,007 - 6,195,027 (-)NCBICelera
Cytogenetic Map4A1NCBI
cM Map42.91NCBI
LOC102008593
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545417,036,204 - 17,042,756 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545417,035,105 - 17,078,854 (-)NCBIChiLan1.0ChiLan1.0
CYP7A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2774,184,135 - 74,194,121 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1849,837,992 - 49,847,979 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0854,942,509 - 54,952,500 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1856,593,799 - 56,603,933 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl856,593,799 - 56,604,037 (-)Ensemblpanpan1.1panPan2
CYP7A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1299,285,315 - 9,295,895 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl299,286,181 - 9,332,310 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha299,598,242 - 9,625,248 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0299,370,713 - 9,397,915 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl299,371,580 - 9,417,428 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1299,368,643 - 9,395,863 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0299,494,537 - 9,521,733 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0299,773,555 - 9,801,001 (-)NCBIUU_Cfam_GSD_1.0
LOC101970910
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530370,179,849 - 70,187,118 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364964,599,138 - 4,605,653 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364964,599,138 - 4,605,653 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP7A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl474,343,123 - 74,372,621 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1474,343,101 - 74,372,628 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2481,137,378 - 81,166,790 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CYP7A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1854,475,801 - 54,489,329 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl854,477,105 - 54,485,649 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603987,237,971 - 87,247,876 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101701685
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474433,612,901 - 33,619,869 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474433,563,564 - 33,619,851 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Cyp7a1
63 total Variants

Predicted Target Of
Summary Value
Count of predictions:515
Count of miRNA genes:248
Interacting mature miRNAs:315
Transcripts:ENSRNOT00000012819
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 15 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2293666Bmd38Bone mineral density QTL 384.4femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)5894822853948228Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51887394774251464Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5384401847869213Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
2312562Pur18Proteinuria QTL 182.60.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)5213896532656739Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat

1 to 10 of 15 rows
D5Wox31  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2519,388,134 - 19,388,390 (+)MAPPERmRatBN7.2
Rnor_6.0519,369,890 - 19,370,145NCBIRnor6.0
Rnor_5.0524,154,745 - 24,155,000UniSTSRnor5.0
RGSC_v3.4519,718,315 - 19,718,570UniSTSRGSC3.4
Celera518,688,423 - 18,688,678UniSTS
Cytogenetic Map5q12UniSTS
PMC165443P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2519,383,568 - 19,383,689 (+)MAPPERmRatBN7.2
Rnor_6.0519,365,324 - 19,365,444NCBIRnor6.0
Rnor_5.0524,150,179 - 24,150,299UniSTSRnor5.0
RGSC_v3.4519,713,749 - 19,713,869UniSTSRGSC3.4
Celera518,683,857 - 18,683,977UniSTS
Cytogenetic Map5q12UniSTS
RH141579  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2519,378,660 - 19,378,879 (+)MAPPERmRatBN7.2
Rnor_6.0519,360,416 - 19,360,634NCBIRnor6.0
Rnor_5.0524,145,271 - 24,145,489UniSTSRnor5.0
RGSC_v3.4519,708,841 - 19,709,059UniSTSRGSC3.4
Celera518,678,949 - 18,679,167UniSTS
RH 3.4 Map586.8UniSTS
Cytogenetic Map5q12UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
1 6 6 28 72 68 52 9 52 2 101 26 17 16 47 16



Ensembl Acc Id: ENSRNOT00000012819   ⟹   ENSRNOP00000012819
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl519,376,974 - 19,386,688 (-)Ensembl
Rnor_6.0 Ensembl519,358,734 - 19,368,431 (-)Ensembl
RefSeq Acc Id: NM_012942   ⟹   NP_037074
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8524,174,505 - 24,184,202 (-)NCBI
mRatBN7.2519,376,979 - 19,386,676 (-)NCBI
Rnor_6.0519,358,734 - 19,368,431 (-)NCBI
Rnor_5.0524,143,589 - 24,153,286 (-)NCBI
RGSC_v3.4519,707,159 - 19,716,856 (-)RGD
Celera518,677,267 - 18,686,964 (-)RGD
Sequence:
1 to 11 of 11 rows
Protein RefSeqs NP_037074 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA03649 (Get FASTA)   NCBI Sequence Viewer  
  AAA40839 (Get FASTA)   NCBI Sequence Viewer  
  AAA40923 (Get FASTA)   NCBI Sequence Viewer  
  AAA41041 (Get FASTA)   NCBI Sequence Viewer  
  AAA41042 (Get FASTA)   NCBI Sequence Viewer  
  CAA78481 (Get FASTA)   NCBI Sequence Viewer  
  EDM11635 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000012819
  ENSRNOP00000012819.2
GenBank Protein P18125 (Get FASTA)   NCBI Sequence Viewer  
1 to 11 of 11 rows
RefSeq Acc Id: NP_037074   ⟸   NM_012942
- UniProtKB: P51543 (UniProtKB/Swiss-Prot),   P18125 (UniProtKB/Swiss-Prot),   A6JFN9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000012819   ⟸   ENSRNOT00000012819

Name Modeler Protein Id AA Range Protein Structure
AF-P18125-F1-model_v2 AlphaFold P18125 1-503 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13693553
Promoter ID:EPDNEW_R4077
Type:single initiation site
Name:Cyp7a1_1
Description:cytochrome P450 family 7 subfamily A member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0519,368,459 - 19,368,519EPDNEW


1 to 31 of 31 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-42081 BioCyc
BioCyc Pathway PWY-6061 [bile acid biosynthesis, neutral pathway] BioCyc
BioCyc Pathway Image PWY-6061 BioCyc
Ensembl Genes ENSRNOG00000009488 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000012819 ENTREZGENE
  ENSRNOT00000012819.5 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot
InterPro Cholesterol_7a_monooxygenase UniProtKB/Swiss-Prot
  CYP450_sterol_14alpha_dmase UniProtKB/Swiss-Prot
  Cyt_P450 UniProtKB/Swiss-Prot
  Cyt_P450_CS UniProtKB/Swiss-Prot
  Cyt_P450_CYP7A1-type UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-IV UniProtKB/Swiss-Prot
  Cyt_P450_sf UniProtKB/Swiss-Prot
KEGG Report rno:25428 UniProtKB/Swiss-Prot
NCBI Gene 25428 ENTREZGENE
PANTHER CYTOCHROME P450 FAMILY 7 UniProtKB/Swiss-Prot
  PTHR24304:SF1 UniProtKB/Swiss-Prot
Pfam p450 UniProtKB/Swiss-Prot
PharmGKB CYP7A1 RGD
PhenoGen Cyp7a1 PhenoGen
PIRSF Cytochrome_CYP7A1 UniProtKB/Swiss-Prot
  Cytochrome_CYPVIIA1 UniProtKB/Swiss-Prot
PRINTS EP450IV UniProtKB/Swiss-Prot
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000009488 RatGTEx
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot
UniProt A6JFN9 ENTREZGENE, UniProtKB/TrEMBL
  CP7A1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  P51543 ENTREZGENE
UniProt Secondary P51543 UniProtKB/Swiss-Prot
1 to 31 of 31 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-06-13 Cyp7a1  cytochrome P450 family 7 subfamily A member 1  Cyp7a1  cytochrome P450, family 7, subfamily a, polypeptide 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Cyp7a1  cytochrome P450, family 7, subfamily a, polypeptide 1    cytochrome P450, 7a1  Name updated 625702 APPROVED
2002-06-10 Cyp7a1  cytochrome P450, 7a1      Name updated 70585 PROVISIONAL

Note Type Note Reference
gene_expression present in the liver 70535
gene_function rate-limiting enzyme in bile acid biosynthesis neutral pathway 68679
gene_process regulates the cholesterol supply pathways 70536
gene_process regulates bile acid biosynthesis and cholesterol homeostasis 68679
gene_process regulates bile acid biosynthesis and cholesterol homeostasis 70535
gene_product 503 amino acid protein 70535
gene_product member of the cytochrome P-450 enzyme family 70535
gene_regulation promoter activity repressed by activated FXR/RXR heterodimer 68679
gene_regulation cholestyramine treatment caused 2-3 fold increase in the mRNA proving cholesterol is an important regulator 70534
gene_regulation transcription down regulated by bile acids via activation of the JNK/c-Jun pathway 68679
gene_transcript cDNA contains 3561 bp and a poly(A) tail of 65 A residues 70534
gene_transcript cDNA contains 3561 bp and a poly(A) tail of 65 A residues 70535
gene_transcript has LXR alpha and LXR beta nuclear receptors in the promoter region 70536