Cyp7a1 (cytochrome P450 family 7 subfamily A member 1) - Rat Genome Database
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Gene: Cyp7a1 (cytochrome P450 family 7 subfamily A member 1) Rattus norvegicus
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Symbol: Cyp7a1
Name: cytochrome P450 family 7 subfamily A member 1
RGD ID: 2482
Description: Exhibits cholesterol 7-alpha-monooxygenase activity. Involved in several processes, including bile acid biosynthetic process; cellular response to cholesterol; and regulation of lipid biosynthetic process. Localizes to intracellular membrane-bounded organelle. Biomarker of alcoholic hepatitis; cholestasis; extrahepatic cholestasis; and non-alcoholic steatohepatitis. Orthologous to human CYP7A1 (cytochrome P450 family 7 subfamily A member 1); PARTICIPATES IN bile acid signaling pathway; bile acid biosynthetic pathway; bile acid signaling pathway; INTERACTS WITH (+)-schisandrin B; (-)-epigallocatechin 3-gallate; (25R)-cholest-5-ene-3beta,26-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 24-hydroxycholesterol 7-alpha-hydroxylase; CHAP; cholesterol 7 alpha-hydroxylase; cholesterol 7-alpha hydroxylase; cholesterol 7-alpha-hydroxylase; cholesterol 7-alpha-monooxygenase; CYP7; CYP7S1; CYPVII; Cytochrom P450 (cholesterol hydroxylase 7 alpha); cytochrome P450 (cholesterol hydroxylase 7 alpha); cytochrome P450 7A1; cytochrome P450, 7a1; cytochrome P450, family 7, subfamily a, polypeptide 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0519,358,734 - 19,368,431 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl519,358,734 - 19,368,431 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0524,143,589 - 24,153,286 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4519,707,159 - 19,716,856 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1519,707,158 - 19,716,856 (-)NCBI
Celera518,677,267 - 18,686,964 (-)NCBICelera
Cytogenetic Map5q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
(24S)-24-hydroxycholesterol  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (EXP,ISO)
(E)-thiamethoxam  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (ISO)
1,4-dithiothreitol  (EXP)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-arachidonoylglycerol  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
20-hydroxycholesterol  (EXP,ISO)
25-hydroxycholesterol  (EXP,ISO)
26-hydroxycholesterol  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-phenylprop-2-enal  (ISO)
7-ketocholesterol  (EXP)
7alpha-hydroxycholesterol  (EXP)
acrylamide  (EXP)
Actein  (EXP)
aflatoxin B1  (ISO)
alfacalcidol  (ISO)
all-trans-retinoic acid  (EXP,ISO)
AM-251  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
amphibole asbestos  (ISO)
angelicin  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atazanavir sulfate  (ISO)
atorvastatin calcium  (EXP,ISO)
atrazine  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-hexachlorocyclohexane  (ISO)
beta-naphthoflavone  (ISO)
bezafibrate  (EXP,ISO)
bilirubin IXalpha  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bosentan  (ISO)
bromobenzene  (EXP)
cadmium dichloride  (EXP)
calcipotriol  (ISO)
calcitriol  (ISO)
carbendazim  (ISO)
carbon nanotube  (ISO)
chenodeoxycholic acid  (EXP,ISO)
chitosan  (EXP)
chlormequat chloride  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
cholate  (ISO)
cholesta-5,7-dien-3beta-ol  (EXP)
cholesterol  (EXP,ISO)
cholic acid  (EXP,ISO)
chrysophanol  (EXP)
ciguatoxin CTX1B  (ISO)
clofibrate  (EXP,ISO)
cobalt atom  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
coumarin  (EXP)
cyclosporin A  (ISO)
cyproconazole  (EXP,ISO)
cyprodinil  (ISO)
cysteamine  (EXP)
DDE  (ISO)
deoxycholic acid  (EXP,ISO)
dexamethasone  (EXP)
dextran sulfate  (ISO)
diallyl trisulfide  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
difenoconazole  (ISO)
dihydroartemisinin  (EXP)
Diisodecyl phthalate  (ISO)
dimethomorph  (ISO)
dimethyl sulfoxide  (EXP)
diosgenin  (EXP)
dioxygen  (ISO)
elemental selenium  (EXP)
emodin  (EXP)
endosulfan  (EXP,ISO)
enilconazole  (ISO)
Epomediol  (EXP)
epoxiconazole  (EXP,ISO)
ethanol  (EXP,ISO)
ethoprophos  (ISO)
fenbuconazole  (ISO)
fenhexamid  (ISO)
fenofibrate  (EXP,ISO)
fenpyroximate  (ISO)
fenvalerate  (EXP)
fipronil  (ISO)
fisetin  (EXP)
flavonoids  (EXP)
fludioxonil  (ISO)
flusilazole  (ISO)
flutamide  (EXP)
fluxapyroxad  (ISO)
furan  (EXP,ISO)
gemfibrozil  (ISO)
genistein  (EXP)
Gentiopicrin  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glycyrrhizinic acid  (ISO)
guggulsterone  (EXP,ISO)
GW 3965  (EXP)
GW 4064  (EXP,ISO)
Heliotrine  (ISO)
hyperforin  (ISO)
imipenem hydrate  (ISO)
indoxyl sulfate  (ISO)
iprodione  (ISO)
isoniazide  (EXP,ISO)
ketoconazole  (EXP)
kojic acid  (ISO)
L-1,4-dithiothreitol  (EXP)
L-ascorbic acid  (ISO)
Lasiocarpine  (ISO)
lead nitrate  (EXP,ISO)
lead(0)  (EXP)
lead(2+)  (EXP)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (EXP,ISO)
magnesium atom  (EXP)
maneb  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
melatonin  (ISO)
mercaptoethanol  (EXP)
mercury atom  (EXP)
mercury(0)  (EXP)
metacetamol  (ISO)
metalaxyl  (ISO)
metformin  (EXP)
methapyrilene  (EXP)
methotrexate  (EXP,ISO)
methoxsalen  (EXP,ISO)
methoxychlor  (EXP)
monocrotaline  (ISO)
monocrotophos  (EXP)
monosodium L-glutamate  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (ISO)
nickel atom  (ISO)
O-methyleugenol  (ISO)
obeticholic acid  (EXP,ISO)
okadaic acid  (ISO)
oleanolic acid  (ISO)
orphenadrine  (EXP)
oxybenzone  (EXP)
p-chloromercuribenzoic acid  (EXP)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perflubutane  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorobutyric acid  (EXP)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
perfluoroundecanoic acid  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidylcholine  (EXP)
pioglitazone  (ISO)
pirinixic acid  (ISO)
pregnenolone  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
prochloraz  (ISO)
propiconazole  (ISO)
psoralen  (EXP)
puerarin  (EXP)
PX-866  (ISO)
pyrazinecarboxamide  (EXP)
pyrrolidines  (EXP)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rifaximin  (ISO)
ritonavir  (EXP,ISO)
rotenone  (EXP)
Salidroside  (ISO)
selenium atom  (EXP)
senecionine  (EXP,ISO)
Senkirkine  (ISO)
sevoflurane  (EXP)
sodium arsenite  (ISO)
sodium cholate  (ISO)
sodium dichromate  (EXP)
soybean oil  (EXP)
spironolactone  (EXP)
streptozocin  (EXP,ISO)
tamoxifen  (EXP,ISO)
taurocholic acid  (EXP,ISO)
tebuconazole  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP,ISO)
thiacloprid  (ISO)
thiamethoxam  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP,ISO)
triphenyl phosphate  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
trovafloxacin  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP,ISO)
usnic acid  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
Yangonin  (ISO)
zinc atom  (EXP,ISO)
zinc pyrithione  (ISO)
zinc(0)  (EXP,ISO)

References

References - curated
1. Chiang JY, etal., Gene 2001 Jan 10;262(1-2):257-65.
2. Fiorucci S, etal., Gastroenterology. 2004 Nov;127(5):1497-512. doi: 10.1053/j.gastro.2004.08.001.
3. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. GOA data from the GO Consortium
5. Gupta S, etal., J Biol Chem 2001 May 11;276(19):15816-22.
6. Han H, etal., Cell Physiol Biochem. 2018;49(4):1304-1319. doi: 10.1159/000493409. Epub 2018 Sep 17.
7. Hu YB, etal., Drug Des Devel Ther. 2018 Jul 16;12:2213-2221. doi: 10.2147/DDDT.S170518. eCollection 2018.
8. Huo XK, etal., Phytomedicine. 2018 Mar 15;42:34-42. doi: 10.1016/j.phymed.2018.03.017. Epub 2018 Mar 8.
9. Jelinek DF and Russell DW, Biochemistry 1990 Aug 28;29(34):7781-5.
10. Jelinek DF, etal., J Biol Chem 1990 May 15;265(14):8190-7.
11. Jiao N, etal., Gut. 2018 Oct;67(10):1881-1891. doi: 10.1136/gutjnl-2017-314307. Epub 2017 Aug 3.
12. Kang S, etal., J Biol Chem 2003 Aug 15;278(33):30478-86. Epub 2003 May 30.
13. KEGG
14. Lehmann JM, etal., J Biol Chem 1997 Feb 7;272(6):3137-40.
15. Li T, etal., Hepatology. 2013 Sep;58(3):1111-21. doi: 10.1002/hep.26427. Epub 2013 Jul 31.
16. Li YC, etal., J Biol Chem 1990 Jul 15;265(20):12012-9.
17. Maeda Y, etal., Ann Clin Lab Sci. 2005 Summer;35(3):323-8.
18. MGD data from the GO Consortium
19. NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. Nishimoto M, etal., J Biol Chem 1991 Apr 5;266(10):6467-71.
21. Noshiro M, etal., J Biol Chem 1990 Jun 15;265(17):10036-41.
22. Pipeline to import KEGG annotations from KEGG into RGD
23. Pipeline to import SMPDB annotations from SMPDB into RGD
24. RGD automated data pipeline
25. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. RGD automated import pipeline for gene-chemical interactions
27. Takeyama Y, etal., Med Mol Morphol. 2017 Dec;50(4):227-237. doi: 10.1007/s00795-017-0166-7. Epub 2017 Jun 28.
28. Xu W, etal., Toxicol Appl Pharmacol. 2017 Jan 15;315:23-34. doi: 10.1016/j.taap.2016.12.001. Epub 2016 Dec 6.
29. Yan LP, etal., Life Sci. 2006 Jun 20;79(4):324-30. doi: 10.1016/j.lfs.2006.01.016. Epub 2006 Feb 10.
30. Zhu L, etal., J Hepatobiliary Pancreat Sci. 2018 Mar;25(3):195-205. doi: 10.1002/jhbp.537.
Additional References at PubMed
PMID:1420318   PMID:2806567   PMID:8021257   PMID:11279518   PMID:12054605   PMID:12077124   PMID:12114517   PMID:12223476   PMID:12554795   PMID:15845870   PMID:18226361   PMID:18292185  
PMID:18578998   PMID:18696335   PMID:19788618   PMID:19957370   PMID:19965590   PMID:20215401   PMID:20362056   PMID:21147774   PMID:21372147   PMID:21817852   PMID:23108811   PMID:23146761  
PMID:23617777   PMID:23852734   PMID:26475369   PMID:26663205   PMID:27133208   PMID:29028359   PMID:31288013  


Genomics

Comparative Map Data
Cyp7a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0519,358,734 - 19,368,431 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl519,358,734 - 19,368,431 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0524,143,589 - 24,153,286 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4519,707,159 - 19,716,856 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1519,707,158 - 19,716,856 (-)NCBI
Celera518,677,267 - 18,686,964 (-)NCBICelera
Cytogenetic Map5q12NCBI
CYP7A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl858,490,178 - 58,500,163 (-)EnsemblGRCh38hg38GRCh38
GRCh38858,490,178 - 58,500,163 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37859,402,737 - 59,412,720 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36859,565,292 - 59,575,275 (-)NCBINCBI36hg18NCBI36
Build 34859,565,291 - 59,575,275NCBI
Celera855,395,751 - 55,405,734 (-)NCBI
Cytogenetic Map8q12.1NCBI
HuRef854,889,962 - 54,899,885 (-)NCBIHuRef
CHM1_1859,454,626 - 59,464,609 (-)NCBICHM1_1
Cyp7a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3946,265,612 - 6,275,632 (-)NCBIGRCm39mm39
GRCm3846,265,612 - 6,275,632 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl46,265,612 - 6,275,633 (-)EnsemblGRCm38mm10GRCm38
MGSCv3746,192,759 - 6,202,778 (-)NCBIGRCm37mm9NCBIm37
MGSCv3646,192,759 - 6,202,778 (-)NCBImm8
Celera46,185,007 - 6,195,027 (-)NCBICelera
Cytogenetic Map4A1NCBI
LOC102008593
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545417,036,204 - 17,042,756 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545417,035,105 - 17,078,854 (-)NCBIChiLan1.0ChiLan1.0
CYP7A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1856,593,799 - 56,603,933 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl856,593,799 - 56,604,037 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0854,942,509 - 54,952,500 (-)NCBIMhudiblu_PPA_v0panPan3
CYP7A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl299,286,181 - 9,332,310 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1299,285,315 - 9,295,895 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
LOC101970910
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364964,599,138 - 4,605,653 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP7A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl474,342,856 - 74,372,638 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1474,343,101 - 74,372,628 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2481,137,378 - 81,166,790 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CYP7A1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1854,475,801 - 54,489,329 (-)NCBI
ChlSab1.1 Ensembl854,477,105 - 54,485,649 (-)Ensembl
LOC101701685
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474433,563,564 - 33,619,851 (+)NCBI

Position Markers
D5Wox31  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0519,369,890 - 19,370,145NCBIRnor6.0
Rnor_5.0524,154,745 - 24,155,000UniSTSRnor5.0
RGSC_v3.4519,718,315 - 19,718,570UniSTSRGSC3.4
Celera518,688,423 - 18,688,678UniSTS
Cytogenetic Map5q12UniSTS
PMC165443P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0519,365,324 - 19,365,444NCBIRnor6.0
Rnor_5.0524,150,179 - 24,150,299UniSTSRnor5.0
RGSC_v3.4519,713,749 - 19,713,869UniSTSRGSC3.4
Celera518,683,857 - 18,683,977UniSTS
Cytogenetic Map5q12UniSTS
RH141579  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0519,360,416 - 19,360,634NCBIRnor6.0
Rnor_5.0524,145,271 - 24,145,489UniSTSRnor5.0
RGSC_v3.4519,708,841 - 19,709,059UniSTSRGSC3.4
Celera518,678,949 - 18,679,167UniSTS
Cytogenetic Map5q12UniSTS
RH 3.4 Map586.8UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51136640934Rat
61462Niddm10Non-insulin dependent diabetes mellitus QTL 103.90.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)5452573847978104Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5193273395Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5189432042Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5325132948722188Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51328888858288888Rat
2293666Bmd38Bone mineral density QTL 384.4femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)5863228553632285Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512651967117554267Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51884791376608178Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)5152509878720537Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51884791363847913Rat
2312562Pur18Proteinuria QTL 182.60.001total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)5152509833001026Rat
2313085Bss59Bone structure and strength QTL 592.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)5325132926252076Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5166658771552720Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)59514842103580403Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:515
Count of miRNA genes:248
Interacting mature miRNAs:315
Transcripts:ENSRNOT00000012819
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 20 20 20
Low 12 11 11 5 2
Below cutoff 4 17 4 9 4 6 6 5 8 23 4 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000012819   ⟹   ENSRNOP00000012819
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl519,358,734 - 19,368,431 (-)Ensembl
RefSeq Acc Id: NM_012942   ⟹   NP_037074
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0519,358,734 - 19,368,431 (-)NCBI
Rnor_5.0524,143,589 - 24,153,286 (-)NCBI
RGSC_v3.4519,707,159 - 19,716,856 (-)RGD
Celera518,677,267 - 18,686,964 (-)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_037074   ⟸   NM_012942
- UniProtKB: P18125 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000012819   ⟸   ENSRNOT00000012819

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693553
Promoter ID:EPDNEW_R4077
Type:single initiation site
Name:Cyp7a1_1
Description:cytochrome P450 family 7 subfamily A member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0519,368,459 - 19,368,519EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2482 AgrOrtholog
Ensembl Genes ENSRNOG00000009488 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000012819 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000012819 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot
InterPro Cholesterol_7a_monooxygenase UniProtKB/Swiss-Prot
  Cyt_P450 UniProtKB/Swiss-Prot
  Cyt_P450_CS UniProtKB/Swiss-Prot
  Cyt_P450_CYP7A1-type UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-IV UniProtKB/Swiss-Prot
  Cyt_P450_sf UniProtKB/Swiss-Prot
KEGG Report rno:25428 UniProtKB/Swiss-Prot
NCBI Gene 25428 ENTREZGENE
PANTHER PTHR24304:SF1 UniProtKB/Swiss-Prot
Pfam p450 UniProtKB/Swiss-Prot
PharmGKB CYP7A1 RGD
PhenoGen Cyp7a1 PhenoGen
PIRSF Cytochrome_CYP7A1 UniProtKB/Swiss-Prot
  Cytochrome_CYPVIIA1 UniProtKB/Swiss-Prot
PRINTS EP450IV UniProtKB/Swiss-Prot
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot
UniGene Rn.10737 ENTREZGENE
UniProt CP7A1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P51543 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-06-13 Cyp7a1  cytochrome P450 family 7 subfamily A member 1  Cyp7a1  cytochrome P450, family 7, subfamily a, polypeptide 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Cyp7a1  cytochrome P450, family 7, subfamily a, polypeptide 1    cytochrome P450, 7a1  Name updated 625702 APPROVED
2002-06-10 Cyp7a1  cytochrome P450, 7a1      Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression present in the liver 70535
gene_function rate-limiting enzyme in bile acid biosynthesis neutral pathway 68679
gene_process regulates the cholesterol supply pathways 70536
gene_process regulates bile acid biosynthesis and cholesterol homeostasis 68679
gene_process regulates bile acid biosynthesis and cholesterol homeostasis 70535
gene_product 503 amino acid protein 70535
gene_product member of the cytochrome P-450 enzyme family 70535
gene_regulation promoter activity repressed by activated FXR/RXR heterodimer 68679
gene_regulation cholestyramine treatment caused 2-3 fold increase in the mRNA proving cholesterol is an important regulator 70534
gene_regulation transcription down regulated by bile acids via activation of the JNK/c-Jun pathway 68679
gene_transcript cDNA contains 3561 bp and a poly(A) tail of 65 A residues 70534
gene_transcript cDNA contains 3561 bp and a poly(A) tail of 65 A residues 70535
gene_transcript has LXR alpha and LXR beta nuclear receptors in the promoter region 70536