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Gene: Cyp7a1 (cytochrome P450, family 7, subfamily a, polypeptide 1) Mus musculus
Symbol: Cyp7a1
Name: cytochrome P450, family 7, subfamily a, polypeptide 1
RGD ID: 10458
Description: Exhibits cholesterol 7-alpha-monooxygenase activity. Involved in cholesterol catabolic process. Predicted to localize to intracellular membrane-bounded organelle. Is expressed in liver. Orthologous to human CYP7A1 (cytochrome P450 family 7 subfamily A member 1); PARTICIPATES IN bile acid biosynthetic pathway; bile acid signaling pathway; cerebrotendinous xanthomatosis pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,2-dichloroethane; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 24-hydroxycholesterol 7-alpha-hydroxylase; cholesterol 7 alpha hydroxylase; cholesterol 7-alpha-hydroxylase; cholesterol 7-alpha-monooxygenase; CYPVII; CYPVIIc; cytochrome P450 7A1; cytochrome P450, 7a1
Homo sapiens (human) : CYP7A1 (cytochrome P450 family 7 subfamily A member 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cyp7a1 (cytochrome P450 family 7 subfamily A member 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : LOC102008593 (cholesterol 7-alpha-monooxygenase)
Pan paniscus (bonobo/pygmy chimpanzee) : CYP7A1 (cytochrome P450 family 7 subfamily A member 1)
Canis lupus familiaris (dog) : CYP7A1 (cytochrome P450 family 7 subfamily A member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101970910 (cholesterol 7-alpha-monooxygenase)
Sus scrofa (pig) : CYP7A1 (cytochrome P450 family 7 subfamily A member 1)
Chlorocebus sabaeus (African green monkey) : CYP7A1 (cytochrome P450 family 7 subfamily A member 1)
Heterocephalus glaber (naked mole-rat) : LOC101701685 (cholesterol 7-alpha-monooxygenase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3946,265,612 - 6,275,632 (-)NCBI
GRCm3846,265,612 - 6,275,632 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl46,265,612 - 6,275,633 (-)EnsemblGRCm38mm10GRCm38
MGSCv3746,192,759 - 6,202,778 (-)NCBIGRCm37mm9NCBIm37
MGSCv3646,192,759 - 6,202,778 (-)NCBImm8
Celera46,185,007 - 6,195,027 (-)NCBICelera
Cytogenetic Map4A1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Cyp7a1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10458
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.