CYP7A1 (cytochrome P450 family 7 subfamily A member 1) - Rat Genome Database

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Gene: CYP7A1 (cytochrome P450 family 7 subfamily A member 1) Sus scrofa
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Symbol: CYP7A1
Name: cytochrome P450 family 7 subfamily A member 1
RGD ID: 14007685
Description: ENCODES a protein that exhibits cholesterol 7-alpha-monooxygenase activity (ortholog); INVOLVED IN bile acid and bile salt transport (ortholog); bile acid signaling pathway (ortholog); cellular response to cholesterol (ortholog); PARTICIPATES IN bile acid biosynthetic pathway; bile acid signaling pathway; cerebrotendinous xanthomatosis pathway; ASSOCIATED WITH alcoholic hepatitis (ortholog); cholestasis (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN intracellular membrane-bounded organelle (ortholog); INTERACTS WITH (24S)-24-hydroxycholesterol; (25R)-cholest-5-ene-3beta,26-diol; 20-hydroxycholesterol
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 24-hydroxycholesterol 7-alpha-hydroxylase; cholesterol 7-alpha-hydroxylase; cholesterol 7-alpha-monooxygenase; cholesterol 7alpha-hydroxylase; CYP7; CYPVII; cytochrome P450 7A1; cytochrome P450, family 7, subfamily A, polypeptide 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl474,342,856 - 74,372,638 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1474,343,101 - 74,372,628 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2481,137,378 - 81,166,790 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:18203892  


Genomics

Comparative Map Data
CYP7A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl474,342,856 - 74,372,638 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1474,343,101 - 74,372,628 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2481,137,378 - 81,166,790 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CYP7A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl858,490,178 - 58,500,163 (-)EnsemblGRCh38hg38GRCh38
GRCh38858,490,178 - 58,500,163 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37859,402,737 - 59,412,722 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36859,565,292 - 59,575,275 (-)NCBINCBI36hg18NCBI36
Build 34859,565,291 - 59,575,275NCBI
Celera855,395,751 - 55,405,734 (-)NCBI
Cytogenetic Map8q12.1NCBI
HuRef854,889,962 - 54,899,885 (-)NCBIHuRef
CHM1_1859,454,626 - 59,464,609 (-)NCBICHM1_1
Cyp7a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3946,265,612 - 6,275,632 (-)NCBIGRCm39mm39
GRCm39 Ensembl46,265,612 - 6,275,633 (-)Ensembl
GRCm3846,265,612 - 6,275,632 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl46,265,612 - 6,275,633 (-)EnsemblGRCm38mm10GRCm38
MGSCv3746,192,759 - 6,202,778 (-)NCBIGRCm37mm9NCBIm37
MGSCv3646,192,759 - 6,202,778 (-)NCBImm8
Celera46,185,007 - 6,195,027 (-)NCBICelera
Cytogenetic Map4A1NCBI
Cyp7a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2519,376,979 - 19,386,676 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl519,376,974 - 19,386,688 (-)Ensembl
Rnor_6.0519,358,734 - 19,368,431 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl519,358,734 - 19,368,431 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0524,143,589 - 24,153,286 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4519,707,159 - 19,716,856 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1519,707,158 - 19,716,856 (-)NCBI
Celera518,677,267 - 18,686,964 (-)NCBICelera
Cytogenetic Map5q12NCBI
LOC102008593
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545417,036,204 - 17,042,756 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545417,035,105 - 17,078,854 (-)NCBIChiLan1.0ChiLan1.0
CYP7A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1856,593,799 - 56,603,933 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl856,593,799 - 56,604,037 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0854,942,509 - 54,952,500 (-)NCBIMhudiblu_PPA_v0panPan3
CYP7A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1299,285,315 - 9,295,895 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl299,286,181 - 9,332,310 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha299,598,242 - 9,625,248 (-)NCBI
ROS_Cfam_1.0299,370,713 - 9,397,915 (-)NCBI
UMICH_Zoey_3.1299,368,643 - 9,395,863 (-)NCBI
UNSW_CanFamBas_1.0299,494,537 - 9,521,733 (-)NCBI
UU_Cfam_GSD_1.0299,773,555 - 9,801,001 (-)NCBI
LOC101970910
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530370,179,849 - 70,187,118 (+)NCBI
SpeTri2.0NW_0049364964,599,138 - 4,605,653 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP7A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1854,475,801 - 54,489,329 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl854,477,105 - 54,485,649 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603987,237,971 - 87,247,876 (+)NCBIVero_WHO_p1.0
LOC101701685
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474433,563,564 - 33,619,851 (+)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system musculoskeletal system nervous system reproductive system respiratory system
High
Medium 2
Low 1
Below cutoff 2 1 7 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000006836   ⟹   ENSSSCP00000006650
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl474,343,123 - 74,372,621 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000037500   ⟹   ENSSSCP00000038374
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl474,363,869 - 74,372,638 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000060847   ⟹   ENSSSCP00000033898
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl474,342,856 - 74,372,638 (+)Ensembl
RefSeq Acc Id: NM_001005352   ⟹   NP_001005352
RefSeq Status: VALIDATED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1474,343,123 - 74,372,621 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005663075   ⟹   XP_005663132
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1474,343,101 - 74,372,628 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005663076   ⟹   XP_005663133
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1474,343,101 - 74,372,628 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013996745   ⟹   XP_013852199
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1474,343,101 - 74,372,628 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021088746   ⟹   XP_020944405
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1474,355,512 - 74,372,628 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_005663133   ⟸   XM_005663076
- Peptide Label: isoform X2
- UniProtKB: F1RT71 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013852199   ⟸   XM_013996745
- Peptide Label: isoform X2
- UniProtKB: F1RT71 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005663132   ⟸   XM_005663075
- Peptide Label: isoform X2
- UniProtKB: F1RT71 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001005352   ⟸   NM_001005352
- UniProtKB: F1RT71 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020944405   ⟸   XM_021088746
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSSSCP00000006650   ⟸   ENSSSCT00000006836
RefSeq Acc Id: ENSSSCP00000033898   ⟸   ENSSSCT00000060847
RefSeq Acc Id: ENSSSCP00000038374   ⟸   ENSSSCT00000037500


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000006238 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025045274 UniProtKB/Swiss-Prot
  ENSSSCG00035027837 UniProtKB/Swiss-Prot
  ENSSSCG00055005084 UniProtKB/Swiss-Prot
  ENSSSCG00070002514 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000006650 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000033898 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000038374 UniProtKB/TrEMBL
  ENSSSCP00025026104 UniProtKB/Swiss-Prot
  ENSSSCP00035014675 UniProtKB/Swiss-Prot
  ENSSSCP00055007897 UniProtKB/Swiss-Prot
  ENSSSCP00070003851 UniProtKB/TrEMBL
  ENSSSCP00070003923 UniProtKB/Swiss-Prot
  ENSSSCP00070003957 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000006836 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000037500 UniProtKB/TrEMBL
  ENSSSCT00000060847 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00025061478 UniProtKB/Swiss-Prot
  ENSSSCT00035036823 UniProtKB/Swiss-Prot
  ENSSSCT00055009982 UniProtKB/Swiss-Prot
  ENSSSCT00070004699 UniProtKB/TrEMBL
  ENSSSCT00070004802 UniProtKB/Swiss-Prot
  ENSSSCT00070004849 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cholesterol_7a_monooxygenase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CYP7A1-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-IV UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:448985 UniProtKB/TrEMBL
NCBI Gene CYP7A1 ENTREZGENE
PANTHER PTHR24304:SF1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PIRSF Cytochrome_CYP7A1 UniProtKB/Swiss-Prot
  Cytochrome_CYPVIIA1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS EP450IV UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0H4ITX7_PIG UniProtKB/TrEMBL
  A0A286ZQK5_PIG UniProtKB/TrEMBL
  A0A287A389_PIG UniProtKB/TrEMBL
  A0A4X1SMV2_PIG UniProtKB/TrEMBL
  A0A4X1SN36_PIG UniProtKB/TrEMBL
  CP7A1_PIG UniProtKB/Swiss-Prot
  F1RT71 ENTREZGENE, UniProtKB/TrEMBL
  O46491 ENTREZGENE
VGNC ID VGNC:98774 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-03-10 CYP7A1  cytochrome P450 family 7 subfamily A member 1  CYP7A1  cytochrome P450, family 7, subfamily A, polypeptide 1  Symbol and/or name change 5135510 APPROVED