CYP7A1 (cytochrome P450 family 7 subfamily A member 1) - Rat Genome Database
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Gene: CYP7A1 (cytochrome P450 family 7 subfamily A member 1) Homo sapiens
Analyze
Symbol: CYP7A1
Name: cytochrome P450 family 7 subfamily A member 1
RGD ID: 69210
HGNC Page HGNC
Description: Exhibits cholesterol 7-alpha-monooxygenase activity. Involved in bile acid biosynthetic process; cellular response to glucose stimulus; and regulation of bile acid biosynthetic process. Predicted to localize to intracellular membrane-bounded organelle. Biomarker of non-alcoholic steatohepatitis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 24-hydroxycholesterol 7-alpha-hydroxylase; cholesterol 7-alpha-hydroxylase; cholesterol 7-alpha-monooxygenase; cholesterol 7alpha-hydroxylase; CP7A; CYP7; CYPVII; cytochrome P450 7A1; cytochrome P450, family 7, subfamily A, polypeptide 1; cytochrome P450, subfamily VIIA polypeptide 1; MGC126826; MGC138389
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl858,490,178 - 58,500,163 (-)EnsemblGRCh38hg38GRCh38
GRCh38858,490,178 - 58,500,163 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37859,402,737 - 59,412,722 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh37859,402,737 - 59,412,720 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36859,565,292 - 59,575,275 (-)NCBINCBI36hg18NCBI36
Build 34859,565,291 - 59,575,275NCBI
Celera855,395,751 - 55,405,734 (-)NCBI
Cytogenetic Map8q12.1NCBI
HuRef854,889,962 - 54,899,885 (-)NCBIHuRef
CHM1_1859,454,626 - 59,464,609 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(24S)-24-hydroxycholesterol  (EXP)
(25R)-cholest-5-ene-3beta,26-diol  (EXP,ISO)
(E)-thiamethoxam  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (ISO)
1,4-dithiothreitol  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrotoluene  (ISO)
2,4-dinitrotoluene  (ISO)
2-acetamidofluorene  (ISO)
2-arachidonoylglycerol  (EXP,ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
20-hydroxycholesterol  (EXP,ISO)
25-hydroxycholesterol  (EXP,ISO)
26-hydroxycholesterol  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-phenylprop-2-enal  (EXP)
7-ketocholesterol  (ISO)
7alpha-hydroxycholesterol  (ISO)
acrylamide  (ISO)
Actein  (ISO)
aflatoxin B1  (EXP,ISO)
alfacalcidol  (ISO)
all-trans-retinoic acid  (EXP,ISO)
AM-251  (ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
amphibole asbestos  (EXP)
angelicin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
atazanavir sulfate  (EXP)
atorvastatin calcium  (ISO)
atrazine  (ISO)
azoxystrobin  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-hexachlorocyclohexane  (EXP,ISO)
beta-naphthoflavone  (EXP)
bezafibrate  (EXP,ISO)
bilirubin IXalpha  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bosentan  (EXP)
bromobenzene  (ISO)
cadmium dichloride  (ISO)
calcipotriol  (EXP)
calcitriol  (EXP)
carbendazim  (EXP)
carbon nanotube  (ISO)
chenodeoxycholic acid  (EXP,ISO)
chitosan  (ISO)
chlormequat chloride  (EXP)
chloroquine  (EXP)
chlorpyrifos  (EXP)
cholate  (EXP,ISO)
cholesta-5,7-dien-3beta-ol  (ISO)
cholesterol  (EXP,ISO)
cholic acid  (EXP,ISO)
chrysophanol  (ISO)
ciguatoxin CTX1B  (ISO)
clofibrate  (ISO)
cobalt atom  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (EXP)
coumarin  (ISO)
cyclosporin A  (EXP,ISO)
cyproconazole  (EXP,ISO)
cyprodinil  (EXP)
cysteamine  (ISO)
DDE  (EXP,ISO)
deoxycholic acid  (EXP,ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (EXP)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dicrotophos  (EXP)
difenoconazole  (EXP)
dihydroartemisinin  (ISO)
Diisodecyl phthalate  (ISO)
dimethomorph  (EXP)
dimethyl sulfoxide  (ISO)
diosgenin  (ISO)
dioxygen  (EXP)
elemental selenium  (ISO)
emodin  (ISO)
endosulfan  (EXP,ISO)
enilconazole  (EXP,ISO)
Epomediol  (ISO)
epoxiconazole  (EXP,ISO)
ethanol  (ISO)
ethoprophos  (EXP)
fenbuconazole  (EXP)
fenhexamid  (EXP)
fenofibrate  (EXP,ISO)
fenpyroximate  (EXP)
fenvalerate  (ISO)
fipronil  (EXP)
fisetin  (ISO)
flavonoids  (ISO)
fludioxonil  (EXP)
flusilazole  (EXP)
flutamide  (ISO)
fluxapyroxad  (EXP)
furan  (ISO)
gemfibrozil  (EXP)
genistein  (ISO)
Gentiopicrin  (ISO)
glycochenodeoxycholic acid  (EXP)
glycocholic acid  (EXP)
glycodeoxycholic acid  (EXP)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glycyrrhizinic acid  (ISO)
guggulsterone  (EXP,ISO)
GW 3965  (ISO)
GW 4064  (EXP,ISO)
Heliotrine  (EXP)
hyperforin  (EXP)
imipenem hydrate  (ISO)
indoxyl sulfate  (EXP)
iprodione  (EXP)
isoniazide  (EXP,ISO)
ketoconazole  (ISO)
kojic acid  (ISO)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (ISO)
Lasiocarpine  (EXP)
lead nitrate  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (EXP,ISO)
magnesium atom  (ISO)
maneb  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
melatonin  (ISO)
mercaptoethanol  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
metacetamol  (ISO)
metalaxyl  (EXP)
metformin  (ISO)
methapyrilene  (ISO)
methotrexate  (EXP,ISO)
methoxsalen  (EXP,ISO)
methoxychlor  (ISO)
monocrotaline  (ISO)
monocrotophos  (ISO)
monosodium L-glutamate  (ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
O-methyleugenol  (EXP)
obeticholic acid  (EXP,ISO)
okadaic acid  (EXP)
oleanolic acid  (ISO)
orphenadrine  (ISO)
oxybenzone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
pentachlorophenol  (ISO)
perflubutane  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorobutyric acid  (ISO)
perfluorodecanoic acid  (EXP,ISO)
perfluorododecanoic acid  (EXP,ISO)
perfluorohexanesulfonic acid  (EXP,ISO)
perfluorohexanoic acid  (EXP)
perfluorononanoic acid  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (EXP)
phenformin  (ISO)
phenobarbital  (EXP,ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
phosphatidylcholine  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
prochloraz  (EXP)
propiconazole  (EXP,ISO)
psoralen  (ISO)
puerarin  (ISO)
PX-866  (ISO)
pyrazinecarboxamide  (ISO)
pyrrolidines  (ISO)
resveratrol  (ISO)
rifampicin  (EXP,ISO)
rifaximin  (EXP)
ritonavir  (EXP,ISO)
rotenone  (ISO)
Salidroside  (ISO)
selenium atom  (ISO)
senecionine  (EXP,ISO)
Senkirkine  (EXP)
sevoflurane  (ISO)
sodium arsenite  (EXP,ISO)
sodium cholate  (ISO)
sodium dichromate  (ISO)
soybean oil  (ISO)
spironolactone  (ISO)
streptozocin  (ISO)
tamoxifen  (ISO)
taurocholic acid  (ISO)
tebuconazole  (EXP)
Tesaglitazar  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
thiacloprid  (EXP)
thiamethoxam  (EXP)
thioacetamide  (ISO)
thiram  (EXP)
titanium dioxide  (ISO)
toluene  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (ISO)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (EXP)
troglitazone  (EXP,ISO)
trovafloxacin  (ISO)
urethane  (EXP)
ursodeoxycholic acid  (EXP,ISO)
usnic acid  (EXP)
valdecoxib  (ISO)
valproic acid  (EXP)
vancomycin  (ISO)
Yangonin  (ISO)
zinc atom  (EXP,ISO)
zinc pyrithione  (EXP)
zinc(0)  (EXP,ISO)

References

Additional References at PubMed
PMID:1312351   PMID:1358792   PMID:1610352   PMID:2384150   PMID:7288293   PMID:8020987   PMID:8439551   PMID:8504159   PMID:9559267   PMID:10359768   PMID:10882719   PMID:11257258  
PMID:11907135   PMID:12011083   PMID:12077124   PMID:12093884   PMID:12093894   PMID:12116231   PMID:12202481   PMID:12213890   PMID:12477932   PMID:12554795   PMID:12721789   PMID:12810154  
PMID:12815072   PMID:12865425   PMID:14515446   PMID:14522988   PMID:14592954   PMID:14762172   PMID:15128046   PMID:15133863   PMID:15205472   PMID:15241483   PMID:15262185   PMID:15333704  
PMID:15489334   PMID:15640003   PMID:15707388   PMID:15736936   PMID:15752749   PMID:15796896   PMID:15805302   PMID:15910869   PMID:16115473   PMID:16630139   PMID:16709249   PMID:16763159  
PMID:16892178   PMID:16917677   PMID:16937432   PMID:17680536   PMID:17920062   PMID:18078817   PMID:18178499   PMID:18270374   PMID:18307386   PMID:18385139   PMID:18660489   PMID:18665040  
PMID:18728123   PMID:18728290   PMID:18996102   PMID:19018779   PMID:19185005   PMID:19343046   PMID:19448895   PMID:19463968   PMID:19537927   PMID:19558216   PMID:19598235   PMID:19850125  
PMID:19956635   PMID:19965590   PMID:20005541   PMID:20031551   PMID:20235787   PMID:20351063   PMID:20403997   PMID:20578904   PMID:20602615   PMID:20686565   PMID:20717043   PMID:20857261  
PMID:20872969   PMID:20884100   PMID:21039385   PMID:21147774   PMID:21346769   PMID:21813643   PMID:21873635   PMID:21902813   PMID:22058145   PMID:22235657   PMID:22607622   PMID:22713451  
PMID:23038264   PMID:23354620   PMID:23458092   PMID:23626788   PMID:23740208   PMID:24097068   PMID:24365583   PMID:24582860   PMID:24927729   PMID:25103562   PMID:25360185   PMID:25499945  
PMID:25944972   PMID:26333513   PMID:26345803   PMID:26521940   PMID:26936139   PMID:27052530   PMID:27106353   PMID:27155186   PMID:27534992   PMID:29115200   PMID:29171472   PMID:29237721  
PMID:29529257   PMID:29721023   PMID:29920211   PMID:30122083   PMID:30354296   PMID:31578885  


Genomics

Comparative Map Data
CYP7A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl858,490,178 - 58,500,163 (-)EnsemblGRCh38hg38GRCh38
GRCh38858,490,178 - 58,500,163 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37859,402,737 - 59,412,722 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh37859,402,737 - 59,412,720 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36859,565,292 - 59,575,275 (-)NCBINCBI36hg18NCBI36
Build 34859,565,291 - 59,575,275NCBI
Celera855,395,751 - 55,405,734 (-)NCBI
Cytogenetic Map8q12.1NCBI
HuRef854,889,962 - 54,899,885 (-)NCBIHuRef
CHM1_1859,454,626 - 59,464,609 (-)NCBICHM1_1
Cyp7a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3946,265,612 - 6,275,632 (-)NCBIGRCm39mm39
GRCm3846,265,612 - 6,275,632 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl46,265,612 - 6,275,633 (-)EnsemblGRCm38mm10GRCm38
MGSCv3746,192,759 - 6,202,778 (-)NCBIGRCm37mm9NCBIm37
MGSCv3646,192,759 - 6,202,778 (-)NCBImm8
Celera46,185,007 - 6,195,027 (-)NCBICelera
Cytogenetic Map4A1NCBI
Cyp7a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2519,376,979 - 19,386,676 (-)NCBI
Rnor_6.0 Ensembl519,358,734 - 19,368,431 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0519,358,734 - 19,368,431 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0524,143,589 - 24,153,286 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4519,707,159 - 19,716,856 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1519,707,158 - 19,716,856 (-)NCBI
Celera518,677,267 - 18,686,964 (-)NCBICelera
Cytogenetic Map5q12NCBI
LOC102008593
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545417,036,204 - 17,042,756 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545417,035,105 - 17,078,854 (-)NCBIChiLan1.0ChiLan1.0
CYP7A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1856,593,799 - 56,603,933 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl856,593,799 - 56,604,037 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0854,942,509 - 54,952,500 (-)NCBIMhudiblu_PPA_v0panPan3
CYP7A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl299,286,181 - 9,332,310 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1299,285,315 - 9,295,895 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
LOC101970910
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364964,599,138 - 4,605,653 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP7A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl474,342,856 - 74,372,638 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1474,343,101 - 74,372,628 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2481,137,378 - 81,166,790 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CYP7A1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1854,475,801 - 54,489,329 (-)NCBI
ChlSab1.1 Ensembl854,477,105 - 54,485,649 (-)Ensembl
LOC101701685
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474433,563,564 - 33,619,851 (+)NCBI

Position Markers
RH17754  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37859,402,957 - 59,403,077UniSTSGRCh37
Build 36859,565,511 - 59,565,631RGDNCBI36
Celera855,395,971 - 55,396,091RGD
Cytogenetic Map8q11-q12UniSTS
HuRef854,890,182 - 54,890,302UniSTS
GeneMap99-GB4 RH Map8320.09UniSTS
SHGC-35322  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37859,403,746 - 59,403,963UniSTSGRCh37
Build 36859,566,300 - 59,566,517RGDNCBI36
Celera855,396,760 - 55,396,977RGD
Cytogenetic Map8q11-q12UniSTS
HuRef854,890,971 - 54,891,188UniSTS
Stanford-G3 RH Map82398.0UniSTS
GeneMap99-GB4 RH Map8320.29UniSTS
Whitehead-RH Map8410.3UniSTS
NCBI RH Map8794.2UniSTS
GeneMap99-G3 RH Map82488.0UniSTS
PMC137182P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37859,410,525 - 59,410,682UniSTSGRCh37
Build 36859,573,079 - 59,573,236RGDNCBI36
Celera855,403,539 - 55,403,696RGD
Cytogenetic Map8q11-q12UniSTS
HuRef854,897,690 - 54,897,847UniSTS
PMC357015P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37859,403,051 - 59,403,433UniSTSGRCh37
Build 36859,565,605 - 59,565,987RGDNCBI36
Celera855,396,065 - 55,396,447RGD
Cytogenetic Map8q11-q12UniSTS
HuRef854,890,276 - 54,890,658UniSTS
CYP7A1_433  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37859,402,685 - 59,403,515UniSTSGRCh37
Build 36859,565,239 - 59,566,069RGDNCBI36
Celera855,395,699 - 55,396,529RGD
HuRef854,889,910 - 54,890,740UniSTS
GDB:213610  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8q11-q12UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR422Ahsa-miR-422aMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assayFunctional MTI20351063
MIR122hsa-miR-122-5pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assayFunctional MTI20351063

Predicted Target Of
Summary Value
Count of predictions:435
Count of miRNA genes:356
Interacting mature miRNAs:380
Transcripts:ENST00000301645
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 193 193 193
Low 16 22 139 134 50 134 552 7 203 1 58 9 355 258
Below cutoff 1954 2247 1063 225 855 82 3152 1677 2498 176 1104 1170 144 834 2176 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000301645   ⟹   ENSP00000301645
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl858,490,178 - 58,500,163 (-)Ensembl
RefSeq Acc Id: NM_000780   ⟹   NP_000771
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38858,490,178 - 58,500,163 (-)NCBI
GRCh37859,402,737 - 59,412,720 (-)ENTREZGENE
Build 36859,565,292 - 59,575,275 (-)NCBI Archive
HuRef854,889,962 - 54,899,885 (-)ENTREZGENE
CHM1_1859,454,626 - 59,464,609 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_000771   ⟸   NM_000780
- UniProtKB: P22680 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000301645   ⟸   ENST00000301645

Promoters
RGD ID:7213357
Promoter ID:EPDNEW_H12424
Type:multiple initiation site
Name:CYP7A1_1
Description:cytochrome P450 family 7 subfamily A member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38858,500,163 - 58,500,223EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_000780.4(CYP7A1):c.578C>T (p.Thr193Ile) single nucleotide variant not provided [RCV000729753] Chr8:58496934 [GRCh38]
Chr8:59409493 [GRCh37]
Chr8:8q12.1
uncertain significance
NM_000780.4(CYP7A1):c.1238_1239del (p.Leu413fs) deletion not provided [RCV000727683] Chr8:58491751..58491752 [GRCh38]
Chr8:59404310..59404311 [GRCh37]
Chr8:8q12.1
uncertain significance
NM_000780.4(CYP7A1):c.763G>A (p.Glu255Lys) single nucleotide variant not provided [RCV000729483] Chr8:58496749 [GRCh38]
Chr8:59409308 [GRCh37]
Chr8:8q12.1
uncertain significance
NM_000780.4(CYP7A1):c.1077C>T (p.Ala359=) single nucleotide variant not provided [RCV000729555] Chr8:58492491 [GRCh38]
Chr8:59405050 [GRCh37]
Chr8:8q12.1
uncertain significance
NM_000780.4(CYP7A1):c.318G>A (p.Ala106=) single nucleotide variant not provided [RCV000728345] Chr8:58498232 [GRCh38]
Chr8:59410791 [GRCh37]
Chr8:8q12.1
uncertain significance
NM_000780.4(CYP7A1):c.165C>T (p.Phe55=) single nucleotide variant not provided [RCV000729084] Chr8:58498385 [GRCh38]
Chr8:59410944 [GRCh37]
Chr8:8q12.1
uncertain significance
NM_000780.4(CYP7A1):c.583C>T (p.Arg195Trp) single nucleotide variant not provided [RCV000729085] Chr8:58496929 [GRCh38]
Chr8:59409488 [GRCh37]
Chr8:8q12.1
uncertain significance
NM_000780.4(CYP7A1):c.157C>T (p.Leu53Phe) single nucleotide variant not provided [RCV000727970] Chr8:58498393 [GRCh38]
Chr8:59410952 [GRCh37]
Chr8:8q12.1
uncertain significance
NM_000780.4(CYP7A1):c.1409T>C (p.Ile470Thr) single nucleotide variant not provided [RCV000728754] Chr8:58491581 [GRCh38]
Chr8:59404140 [GRCh37]
Chr8:8q12.1
uncertain significance
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145049449)x3 copy number gain See cases [RCV000051206] Chr8:241530..145049449 [GRCh38]
Chr8:191530..146274835 [GRCh37]
Chr8:181530..146245639 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q12.1-21.13(chr8:57361243-79170078)x3 copy number gain See cases [RCV000053653] Chr8:57361243..79170078 [GRCh38]
Chr8:58273802..80082313 [GRCh37]
Chr8:58436356..80244868 [NCBI36]
Chr8:8q12.1-21.13
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000053602] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:244417-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|See cases [RCV000053604] Chr8:244417..145054775 [GRCh38]
Chr8:194417..146280161 [GRCh37]
Chr8:184417..146250965 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q12.1(chr8:55423413-58836753)x1 copy number loss See cases [RCV000054240] Chr8:55423413..58836753 [GRCh38]
Chr8:56335973..59749312 [GRCh37]
Chr8:56498527..59911866 [NCBI36]
Chr8:8q12.1
pathogenic
GRCh38/hg38 8q12.1-12.3(chr8:56925812-61691859)x1 copy number loss See cases [RCV000054241] Chr8:56925812..61691859 [GRCh38]
Chr8:57838371..62604418 [GRCh37]
Chr8:58000925..62766972 [NCBI36]
Chr8:8q12.1-12.3
pathogenic
NM_000780.3(CYP7A1):c.275G>A (p.Gly92Glu) single nucleotide variant Malignant melanoma [RCV000068356] Chr8:58498275 [GRCh38]
Chr8:59410834 [GRCh37]
Chr8:59573388 [NCBI36]
Chr8:8q12.1
not provided
NM_000780.4(CYP7A1):c.907A>T (p.Arg303Trp) single nucleotide variant not provided [RCV000122470] Chr8:58496605 [GRCh38]
Chr8:59409164 [GRCh37]
Chr8:8q12.1
uncertain significance
GRCh38/hg38 8q11.1-13.2(chr8:46031334-69303787)x3 copy number gain See cases [RCV000133720] Chr8:46031334..69303787 [GRCh38]
Chr8:46942956..70216022 [GRCh37]
Chr8:47062121..70378576 [NCBI36]
Chr8:8q11.1-13.2
pathogenic
GRCh38/hg38 8q12.1-12.3(chr8:55315854-64952752)x3 copy number gain See cases [RCV000137672] Chr8:55315854..64952752 [GRCh38]
Chr8:56228414..65864987 [GRCh37]
Chr8:56390968..66027541 [NCBI36]
Chr8:8q12.1-12.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241605-145054781)x3 copy number gain See cases [RCV000138643] Chr8:241605..145054781 [GRCh38]
Chr8:191605..146280167 [GRCh37]
Chr8:181605..146250971 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q11.1-24.3(chr8:46031340-139285494)x3 copy number gain See cases [RCV000139539] Chr8:46031340..139285494 [GRCh38]
Chr8:46942962..140297737 [GRCh37]
Chr8:47062127..140366919 [NCBI36]
Chr8:8q11.1-24.3
pathogenic
GRCh38/hg38 8p12-q12.1(chr8:36580103-59618998)x3 copy number gain See cases [RCV000139582] Chr8:36580103..59618998 [GRCh38]
Chr8:36437621..60531557 [GRCh37]
Chr8:36556779..60694111 [NCBI36]
Chr8:8p12-q12.1
pathogenic
GRCh38/hg38 8q12.1-12.2(chr8:54821357-61146302)x1 copy number loss See cases [RCV000140643] Chr8:54821357..61146302 [GRCh38]
Chr8:55733917..62058861 [GRCh37]
Chr8:55896471..62221415 [NCBI36]
Chr8:8q12.1-12.2
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:208048-145070385)x3 copy number gain See cases [RCV000141808] Chr8:208048..145070385 [GRCh38]
Chr8:158048..146295771 [GRCh37]
Chr8:148048..146266575 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p21.3-q24.3(chr8:21291522-145070385)x3 copy number gain See cases [RCV000142021] Chr8:21291522..145070385 [GRCh38]
Chr8:21149033..146295771 [GRCh37]
Chr8:21193313..146266575 [NCBI36]
Chr8:8p21.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:226452-145068712)x3 copy number gain See cases [RCV000142858] Chr8:226452..145068712 [GRCh38]
Chr8:176452..146294098 [GRCh37]
Chr8:166452..146264902 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q11.23-12.3(chr8:53325389-61863018)x1 copy number loss See cases [RCV000143182] Chr8:53325389..61863018 [GRCh38]
Chr8:54237949..62775577 [GRCh37]
Chr8:54400502..62938131 [NCBI36]
Chr8:8q11.23-12.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000148092] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q11.23-12.3(chr8:53436131-65195953)x3 copy number gain See cases [RCV000239428] Chr8:53436131..65195953 [GRCh37]
Chr8:8q11.23-12.3
pathogenic
NM_000780.4(CYP7A1):c.108T>A (p.Asn36Lys) single nucleotide variant not provided [RCV000338265] Chr8:58498442 [GRCh38]
Chr8:59411001 [GRCh37]
Chr8:8q12.1
uncertain significance
NM_000780.4(CYP7A1):c.1357G>A (p.Glu453Lys) single nucleotide variant not provided [RCV000305369] Chr8:58491633 [GRCh38]
Chr8:59404192 [GRCh37]
Chr8:8q12.1
uncertain significance
NM_000780.4(CYP7A1):c.1292A>G (p.Lys431Arg) single nucleotide variant not provided [RCV000338273] Chr8:58491698 [GRCh38]
Chr8:59404257 [GRCh37]
Chr8:8q12.1
uncertain significance
NM_000780.4(CYP7A1):c.81-10T>C single nucleotide variant not provided [RCV000375844] Chr8:58498479 [GRCh38]
Chr8:59411038 [GRCh37]
Chr8:8q12.1
uncertain significance
NM_000780.4(CYP7A1):c.1003T>C (p.Leu335=) single nucleotide variant not provided [RCV000349634] Chr8:58494542 [GRCh38]
Chr8:59407101 [GRCh37]
Chr8:8q12.1
uncertain significance
NM_000780.4(CYP7A1):c.427G>A (p.Glu143Lys) single nucleotide variant not provided [RCV000315439] Chr8:58497085 [GRCh38]
Chr8:59409644 [GRCh37]
Chr8:8q12.1
uncertain significance
NM_000780.4(CYP7A1):c.490G>A (p.Ala164Thr) single nucleotide variant not provided [RCV000390157] Chr8:58497022 [GRCh38]
Chr8:59409581 [GRCh37]
Chr8:8q12.1
uncertain significance
NM_000780.4(CYP7A1):c.779G>T (p.Arg260Leu) single nucleotide variant not provided [RCV000324317] Chr8:58496733 [GRCh38]
Chr8:59409292 [GRCh37]
Chr8:8q12.1
uncertain significance
NM_000780.4(CYP7A1):c.909-4A>C single nucleotide variant not provided [RCV000396585] Chr8:58494640 [GRCh38]
Chr8:59407199 [GRCh37]
Chr8:8q12.1
uncertain significance
NM_000780.4(CYP7A1):c.1192C>G (p.Pro398Ala) single nucleotide variant not provided [RCV000886346]|not specified [RCV000368943] Chr8:58492376 [GRCh38]
Chr8:59404935 [GRCh37]
Chr8:8q12.1
likely benign
NM_000780.4(CYP7A1):c.133G>T (p.Ala45Ser) single nucleotide variant not provided [RCV000598476] Chr8:58498417 [GRCh38]
Chr8:59410976 [GRCh37]
Chr8:8q12.1
uncertain significance
NM_000780.4(CYP7A1):c.900A>G (p.Gln300=) single nucleotide variant not provided [RCV000592180] Chr8:58496612 [GRCh38]
Chr8:59409171 [GRCh37]
Chr8:8q12.1
uncertain significance
NM_000780.4(CYP7A1):c.988G>A (p.Gly330Ser) single nucleotide variant not provided [RCV000592220] Chr8:58494557 [GRCh38]
Chr8:59407116 [GRCh37]
Chr8:8q12.1
uncertain significance
NM_000780.4(CYP7A1):c.124C>T (p.Leu42=) single nucleotide variant not provided [RCV000591873] Chr8:58498426 [GRCh38]
Chr8:59410985 [GRCh37]
Chr8:8q12.1
uncertain significance
NM_000780.4(CYP7A1):c.297A>G (p.Lys99=) single nucleotide variant not specified [RCV000598516] Chr8:58498253 [GRCh38]
Chr8:59410812 [GRCh37]
Chr8:8q12.1
likely benign
NM_000780.4(CYP7A1):c.1382T>C (p.Met461Thr) single nucleotide variant not provided [RCV000592678] Chr8:58491608 [GRCh38]
Chr8:59404167 [GRCh37]
Chr8:8q12.1
uncertain significance
NM_000780.4(CYP7A1):c.1384C>G (p.Leu462Val) single nucleotide variant not provided [RCV000592851] Chr8:58491606 [GRCh38]
Chr8:59404165 [GRCh37]
Chr8:8q12.1
uncertain significance
NM_000780.4(CYP7A1):c.38C>T (p.Ala13Val) single nucleotide variant not provided [RCV000593135] Chr8:58500061 [GRCh38]
Chr8:59412620 [GRCh37]
Chr8:8q12.1
conflicting interpretations of pathogenicity|uncertain significance
NM_000780.4(CYP7A1):c.843G>A (p.Val281=) single nucleotide variant not provided [RCV000595946] Chr8:58496669 [GRCh38]
Chr8:59409228 [GRCh37]
Chr8:8q12.1
uncertain significance
NM_000780.4(CYP7A1):c.206G>T (p.Cys69Phe) single nucleotide variant not provided [RCV000593605] Chr8:58498344 [GRCh38]
Chr8:59410903 [GRCh37]
Chr8:8q12.1
uncertain significance
NM_000780.4(CYP7A1):c.1059G>A (p.Ser353=) single nucleotide variant not specified [RCV000593781] Chr8:58492509 [GRCh38]
Chr8:59405068 [GRCh37]
Chr8:8q12.1
likely benign
NM_000780.4(CYP7A1):c.*5A>G single nucleotide variant not provided [RCV000591224] Chr8:58491470 [GRCh38]
Chr8:59404029 [GRCh37]
Chr8:8q12.1
uncertain significance
NM_000780.4(CYP7A1):c.937G>A (p.Glu313Lys) single nucleotide variant not provided [RCV000597848] Chr8:58494608 [GRCh38]
Chr8:59407167 [GRCh37]
Chr8:8q12.1
uncertain significance
NM_000780.4(CYP7A1):c.1215+3A>G single nucleotide variant not provided [RCV000591534] Chr8:58492350 [GRCh38]
Chr8:59404909 [GRCh37]
Chr8:8q12.1
uncertain significance
NM_000780.4(CYP7A1):c.123C>T (p.Tyr41=) single nucleotide variant not provided [RCV000591597] Chr8:58498427 [GRCh38]
Chr8:59410986 [GRCh37]
Chr8:8q12.1
uncertain significance
NM_000780.4(CYP7A1):c.1091G>A (p.Arg364Gln) single nucleotide variant not provided [RCV000730188] Chr8:58492477 [GRCh38]
Chr8:59405036 [GRCh37]
Chr8:8q12.1
uncertain significance
NM_000780.4(CYP7A1):c.25G>A (p.Gly9Arg) single nucleotide variant not provided [RCV000733746] Chr8:58500074 [GRCh38]
Chr8:59412633 [GRCh37]
Chr8:8q12.1
uncertain significance
NM_000780.4(CYP7A1):c.1473A>G (p.Pro491=) single nucleotide variant not provided [RCV000733164] Chr8:58491517 [GRCh38]
Chr8:59404076 [GRCh37]
Chr8:8q12.1
uncertain significance
NM_000780.4(CYP7A1):c.908+6T>G single nucleotide variant not provided [RCV000732445] Chr8:58496598 [GRCh38]
Chr8:59409157 [GRCh37]
Chr8:8q12.1
uncertain significance
NM_000780.4(CYP7A1):c.498G>A (p.Trp166Ter) single nucleotide variant not provided [RCV000734574] Chr8:58497014 [GRCh38]
Chr8:59409573 [GRCh37]
Chr8:8q12.1
uncertain significance
NM_000780.4(CYP7A1):c.*6_*7delinsAAT indel not provided [RCV000734584] Chr8:58491468..58491469 [GRCh38]
Chr8:59404027..59404028 [GRCh37]
Chr8:8q12.1
uncertain significance
NM_000780.4(CYP7A1):c.322G>A (p.Ala108Thr) single nucleotide variant not provided [RCV000734630] Chr8:58497190 [GRCh38]
Chr8:59409749 [GRCh37]
Chr8:8q12.1
uncertain significance
NM_000780.4(CYP7A1):c.191G>A (p.Gly64Asp) single nucleotide variant not provided [RCV000731655] Chr8:58498359 [GRCh38]
Chr8:59410918 [GRCh37]
Chr8:8q12.1
uncertain significance
NM_000780.4(CYP7A1):c.346C>T (p.Pro116Ser) single nucleotide variant not provided [RCV000732628] Chr8:58497166 [GRCh38]
Chr8:59409725 [GRCh37]
Chr8:8q12.1
uncertain significance
NM_000780.4(CYP7A1):c.1215+8C>T single nucleotide variant not provided [RCV000732716] Chr8:58492345 [GRCh38]
Chr8:59404904 [GRCh37]
Chr8:8q12.1
uncertain significance
NM_000780.4(CYP7A1):c.704G>A (p.Arg235Gln) single nucleotide variant not provided [RCV000731674] Chr8:58496808 [GRCh38]
Chr8:59409367 [GRCh37]
Chr8:8q12.1
uncertain significance
NM_000780.4(CYP7A1):c.1447C>T (p.Arg483Trp) single nucleotide variant not provided [RCV000731822] Chr8:58491543 [GRCh38]
Chr8:59404102 [GRCh37]
Chr8:8q12.1
uncertain significance
NM_000780.4(CYP7A1):c.317C>A (p.Ala106Glu) single nucleotide variant not provided [RCV000731926] Chr8:58498233 [GRCh38]
Chr8:59410792 [GRCh37]
Chr8:8q12.1
uncertain significance
NM_000780.4(CYP7A1):c.818T>C (p.Leu273Pro) single nucleotide variant not provided [RCV000727980] Chr8:58496694 [GRCh38]
Chr8:59409253 [GRCh37]
Chr8:8q12.1
uncertain significance
GRCh37/hg19 8p23.3-q24.3(chr8:158991-146280828)x3 copy number gain See cases [RCV000447507] Chr8:158991..146280828 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771) copy number gain See cases [RCV000510234] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771)x3 copy number gain See cases [RCV000511095] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
NM_000780.4(CYP7A1):c.423C>G (p.Leu141=) single nucleotide variant not provided [RCV000595790] Chr8:58497089 [GRCh38]
Chr8:59409648 [GRCh37]
Chr8:8q12.1
uncertain significance
NM_000780.4(CYP7A1):c.1129G>A (p.Gly377Ser) single nucleotide variant not provided [RCV000597302] Chr8:58492439 [GRCh38]
Chr8:59404998 [GRCh37]
Chr8:8q12.1
uncertain significance
GRCh37/hg19 8p23.1-q24.3(chr8:12490999-146295771)x3 copy number gain See cases [RCV000512169] Chr8:12490999..146295771 [GRCh37]
Chr8:8p23.1-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:164984-146293414)x3 copy number gain not provided [RCV000747254] Chr8:164984..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:10213-146293414)x3 copy number gain not provided [RCV000747248] Chr8:10213..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
NM_000780.4(CYP7A1):c.256C>A (p.His86Asn) single nucleotide variant not provided [RCV000963911] Chr8:58498294 [GRCh38]
Chr8:59410853 [GRCh37]
Chr8:8q12.1
benign
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771)x3 copy number gain not provided [RCV000848478] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p11.22-q12.3(chr8:39555657-64049089)x3 copy number gain not provided [RCV000846266] Chr8:39555657..64049089 [GRCh37]
Chr8:8p11.22-q12.3
pathogenic
GRCh37/hg19 8p12-q24.3(chr8:31936551-146295771)x3 copy number gain not provided [RCV000848192] Chr8:31936551..146295771 [GRCh37]
Chr8:8p12-q24.3
pathogenic
NM_000780.4(CYP7A1):c.81-6T>C single nucleotide variant not provided [RCV000886416] Chr8:58498475 [GRCh38]
Chr8:59411034 [GRCh37]
Chr8:8q12.1
benign
NM_000780.4(CYP7A1):c.1248C>T (p.Asn416=) single nucleotide variant not provided [RCV000956619] Chr8:58491742 [GRCh38]
Chr8:59404301 [GRCh37]
Chr8:8q12.1
benign
NM_000780.4(CYP7A1):c.225T>C (p.Tyr75=) single nucleotide variant not provided [RCV000956620] Chr8:58498325 [GRCh38]
Chr8:59410884 [GRCh37]
Chr8:8q12.1
benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:2651 AgrOrtholog
COSMIC CYP7A1 COSMIC
Ensembl Genes ENSG00000167910 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000301645 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000301645 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot
GTEx ENSG00000167910 GTEx
HGNC ID HGNC:2651 ENTREZGENE
Human Proteome Map CYP7A1 Human Proteome Map
InterPro Cholesterol_7a_monooxygenase UniProtKB/Swiss-Prot
  Cyt_P450 UniProtKB/Swiss-Prot
  Cyt_P450_CS UniProtKB/Swiss-Prot
  Cyt_P450_CYP7A1-type UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-IV UniProtKB/Swiss-Prot
  Cyt_P450_sf UniProtKB/Swiss-Prot
KEGG Report hsa:1581 UniProtKB/Swiss-Prot
NCBI Gene 1581 ENTREZGENE
OMIM 118455 OMIM
PANTHER PTHR24304:SF1 UniProtKB/Swiss-Prot
Pfam p450 UniProtKB/Swiss-Prot
PharmGKB CYP7A1 RGD, PharmGKB
PIRSF Cytochrome_CYP7A1 UniProtKB/Swiss-Prot
  Cytochrome_CYPVIIA1 UniProtKB/Swiss-Prot
PRINTS EP450IV UniProtKB/Swiss-Prot
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot
UniProt CP7A1_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P78454 UniProtKB/Swiss-Prot
  Q3MIL8 UniProtKB/Swiss-Prot
  Q7KZ19 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-15 CYP7A1  cytochrome P450 family 7 subfamily A member 1    cytochrome P450, family 7, subfamily A, polypeptide 1  Symbol and/or name change 5135510 APPROVED