Gene: Twist1 (twist family bHLH transcription factor 1) Rattus norvegicus
Analyze
Symbol:
Twist1
Name:
twist family bHLH transcription factor 1
Description:
Predicted to have several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; E-box binding activity; and protein dimerization activity. Involved in several processes, including animal organ development; positive regulation of epithelial cell proliferation; and roof of mouth development. Localizes to the nucleus. Human ortholog(s) of this gene implicated in Saethre-Chotzen syndrome; Sweeney-Cox syndrome; acrocephalosyndactylia; and craniosynostosis. Orthologous to human TWIST1 (twist family bHLH transcription factor 1); PARTICIPATES IN hypoxia inducible factor pathway; INTERACTS WITH 6-propyl-2-thiouracil; ammonium chloride; benzo[a]pyrene.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
Twist; twist basic helix-loop-helix transcription factor 1; twist gene homolog 1; twist gene homolog 1 (Drosophila); twist gene homolog, (Drosophila); twist homolog 1; twist homolog 1 (Drosophila); twist-related protein 1
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
TWIST1 (twist family bHLH transcription factor 1) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):
Twist1 (twist basic helix-loop-helix transcription factor 1) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Twist1 (twist family bHLH transcription factor 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
TWIST1 (twist family bHLH transcription factor 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Twist1 (twist family bHLH transcription factor 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
TWIST1 (twist family bHLH transcription factor 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
TWIST2 (twist family bHLH transcription factor 2) HGNC
OrthoDB
Alliance orthologs 3
Homo sapiens (human):
TWIST1 (twist family bHLH transcription factor 1)
Alliance
DIOPT (Ensembl Compara, HGNC, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, TreeFam)
Mus musculus (house mouse):
Twist1 (twist basic helix-loop-helix transcription factor 1)
Alliance
DIOPT (Ensembl Compara, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, TreeFam)
Danio rerio (zebrafish):
twist3
Alliance
DIOPT (Ensembl Compara, OrthoFinder, PANTHER, TreeFam)
Danio rerio (zebrafish):
twist1a (twist family bHLH transcription factor 1a)
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder, PANTHER, TreeFam)
Danio rerio (zebrafish):
twist1b (twist family bHLH transcription factor 1b)
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder, PANTHER, TreeFam)
Caenorhabditis elegans (roundworm):
hlh-8
Alliance
DIOPT (Ensembl Compara, OrthoFinder, OrthoInspector, PANTHER)
Drosophila melanogaster (fruit fly):
twi
Alliance
DIOPT (Ensembl Compara, OrthoInspector, PANTHER)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 6 53,401,241 - 53,403,235 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 6 53,401,109 - 53,403,214 (+) Ensembl Rnor_5.0 6 63,023,523 - 63,025,517 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 6 52,605,869 - 52,607,863 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 6 52,609,172 - 52,609,784 (+) NCBI Celera 6 49,841,416 - 49,843,227 (+) NCBI Celera Cytogenetic Map 6 q16 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
Imported Annotations - ClinVar
craniosynostosis ISO RGD:1349130 8554872 ClinVar Annotator: match by term: Craniosynostosis 1 ClinVar PMID:28492532 craniosynostosis ISO RGD:1349130 8554872 ClinVar Annotator: match by term: Craniosynostosis 1 ClinVar PMID:10094188 more ... craniosynostosis ISO RGD:1349130 8554872 ClinVar Annotator: match by term: Craniosynostosis 1 ClinVar PMID:22382802 more ... craniosynostosis ISO RGD:1349130 8554872 ClinVar Annotator: match by term: Craniosynostosis 1 ClinVar PMID:10649491 more ... craniosynostosis ISO RGD:1349130 8554872 ClinVar Annotator: match by term: Craniosynostosis 1 ClinVar PMID:11992718 more ... craniosynostosis ISO RGD:1349130 8554872 ClinVar Annotator: match by term: Craniosynostosis 1 ClinVar PMID:24127277 , PMID:28492532 craniosynostosis ISO RGD:1349130 8554872 ClinVar Annotator: match by term: Craniosynostosis 1 ClinVar PMID:17693524 , PMID:28492532 craniosynostosis ISO RGD:1349130 8554872 ClinVar Annotator: match by term: Craniosynostosis 1 ClinVar PMID:25741868 , PMID:28492532 craniosynostosis ISO RGD:1349130 8554872 ClinVar Annotator: match by term: Craniosynostosis 1 ClinVar PMID:14513358 more ... craniosynostosis ISO RGD:1349130 8554872 ClinVar Annotator: match by term: Craniosynostosis 1 ClinVar PMID:11992718 more ... craniosynostosis ISO RGD:1349130 8554872 ClinVar Annotator: match by term: Craniosynostosis 1 ClinVar PMID:15923834 more ... craniosynostosis ISO RGD:1349130 8554872 ClinVar Annotator: match by term: Craniosynostosis 1 ClinVar PMID:25741868 craniosynostosis ISO RGD:1349130 8554872 ClinVar Annotator: match by OMIM:123100 ClinVar PMID:17343269 Craniosynostosis 3 ISO RGD:1349130 8554872 ClinVar Annotator: match by term: Coronal craniosynostosis ClinVar genetic disease ISO RGD:1349130 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:10465122 more ... pleomorphic xanthoastrocytoma ISO RGD:1349130 8554872 ClinVar Annotator: match by term: Pleomorphic xanthoastrocytoma ClinVar PMID:28299358 Robinow Sorauf Syndrome ISO RGD:1349130 8554872 ClinVar Annotator: match by OMIM:180750 ClinVar PMID:1240778 , PMID:12791045 Robinow Sorauf Syndrome ISO RGD:1349130 8554872 ClinVar Annotator: match by OMIM:180750 ClinVar PMID:10465122 , PMID:12791045 Saethre-Chotzen syndrome ISO RGD:1349130 8554872 ClinVar Annotator: match by null ClinVar PMID:11474656 more ... Saethre-Chotzen syndrome ISO RGD:1349130 8554872 ClinVar Annotator: match by term: Saethre-Chotzen syndrome ClinVar PMID:22382802 more ... Saethre-Chotzen syndrome ISO RGD:1349130 8554872 ClinVar Annotator: match by term: Saethre-Chotzen syndrome ClinVar PMID:10649491 more ... Saethre-Chotzen syndrome ISO RGD:1349130 8554872 ClinVar Annotator: match by term: Saethre-Chotzen syndrome ClinVar PMID:11754069 Saethre-Chotzen syndrome ISO RGD:1349130 8554872 ClinVar Annotator: match by term: Saethre-Chotzen syndrome ClinVar PMID:11248247 , PMID:9259286 Saethre-Chotzen syndrome ISO RGD:1349130 8554872 ClinVar Annotator: match by term: Saethre-Chotzen syndrome ClinVar PMID:9934984 Saethre-Chotzen syndrome ISO RGD:1349130 8554872 ClinVar Annotator: match by term: Saethre-Chotzen syndrome ClinVar PMID:8988166 Saethre-Chotzen syndrome ISO RGD:1349130 8554872 ClinVar Annotator: match by term: Saethre-Chotzen syndrome ClinVar PMID:28492532 Saethre-Chotzen syndrome ISO RGD:1349130 8554872 ClinVar Annotator: match by term: Saethre-Chotzen syndrome ClinVar Saethre-Chotzen syndrome ISO RGD:1349130 8554872 ClinVar Annotator: match by term: Saethre-Chotzen syndrome ClinVar PMID:11248247 Sweeney-Cox syndrome ISO RGD:1349130 8554872 ClinVar Annotator: match by term: SWEENEY-COX SYNDROME ClinVar PMID:27884935 , PMID:28369379 Sweeney-Cox syndrome ISO RGD:1349130 8554872 ClinVar Annotator: match by term: SWEENEY-COX SYNDROME ClinVar PMID:28369379
Imported Annotations - CTD
acrocephalosyndactylia ISO RGD:1349130 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:15923834 , PMID:23354436 anaplastic large cell lymphoma ISO RGD:1349130 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:22155737 craniosynostosis ISO RGD:1349130 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:12221714 Neoplasm Invasiveness ISO RGD:1349130 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:22155737 Neoplasm Metastasis ISO RGD:1349130 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:19806464 Saethre-Chotzen syndrome ISO RGD:1349130 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:11474656 Stomach Neoplasms ISO RGD:1349130 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:19806464 Imported Annotations - OMIM
craniosynostosis ISO RGD:1349130 7240710 OMIM Robinow Sorauf Syndrome ISO RGD:1349130 7240710 OMIM Saethre-Chotzen syndrome ISO RGD:1349130 7240710 OMIM Sweeney-Cox syndrome ISO RGD:1349130 7240710 OMIM
(S)-nicotine increases expression ISO RGD:1349130 6480464 Nicotine results in increased expression of TWIST1 mRNA CTD PMID:23219715 17beta-estradiol decreases expression ISO RGD:1349130 6480464 Estradiol results in decreased expression of TWIST1 mRNA CTD PMID:18692832 17beta-estradiol multiple interactions ISO RGD:1349130 6480464 [Progesterone co-treated with Estradiol] results in decreased expression of TWIST1 mRNA CTD PMID:17404688 , PMID:18692832 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1553211 6480464 Tetrachlorodibenzodioxin affects the expression of TWIST1 mRNA CTD PMID:24058054 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1349130 6480464 Tetrachlorodibenzodioxin affects the expression of TWIST1 mRNA CTD PMID:30203000 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1553211 6480464 Tetrachlorodibenzodioxin promotes the reaction [tributyltin results in decreased expression of TWIST1 mRNA] CTD PMID:22749964 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1553211 6480464 Tetrachlorodibenzodioxin results in increased expression of TWIST1 mRNA CTD PMID:21167638 4,4'-sulfonyldiphenol increases expression ISO RGD:1553211 6480464 bis(4-hydroxyphenyl)sulfone results in increased expression of TWIST1 mRNA CTD PMID:30951980 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one increases expression ISO RGD:1553211 6480464 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of TWIST1 mRNA CTD PMID:21167638 4-hydroxyphenyl retinamide decreases expression ISO RGD:1553211 6480464 Fenretinide results in decreased expression of TWIST1 mRNA CTD PMID:28973697 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of TWIST1 mRNA CTD PMID:24780913 7,12-dimethyltetraphene multiple interactions ISO RGD:1349130 6480464 mithramycin A inhibits the reaction [9 more ... CTD PMID:29663660 7,12-dimethyltetraphene increases expression ISO RGD:1349130 6480464 9 more ... CTD PMID:29663660 afimoxifene multiple interactions ISO RGD:1349130 6480464 afimoxifene inhibits the reaction [Estrogens results in decreased expression of TWIST1 mRNA] CTD PMID:21233418 aflatoxin B1 affects expression ISO RGD:1349130 6480464 Aflatoxin B1 affects the expression of TWIST1 protein CTD PMID:20106945 aflatoxin B1 decreases expression ISO RGD:1349130 6480464 Aflatoxin B1 results in decreased expression of TWIST1 mRNA CTD PMID:28965971 aflatoxin B1 decreases methylation ISO RGD:1349130 6480464 Aflatoxin B1 results in decreased methylation of TWIST1 gene CTD PMID:27153756 all-trans-retinoic acid increases expression ISO RGD:1349130 6480464 Tretinoin results in increased expression of TWIST1 mRNA CTD PMID:21934132 , PMID:23724009 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of TWIST1 mRNA CTD PMID:16483693 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions ISO RGD:1349130 6480464 pyrazolanthrone inhibits the reaction [thymoquinone results in decreased expression of TWIST1 protein] CTD PMID:27060453 arsane decreases response to substance ISO RGD:1349130 6480464 TWIST1 protein results in decreased susceptibility to Arsenic CTD PMID:19806464 arsenic atom decreases response to substance ISO RGD:1349130 6480464 TWIST1 protein results in decreased susceptibility to Arsenic CTD PMID:19806464 arsenite(3-) increases methylation ISO RGD:1349130 6480464 arsenite results in increased methylation of TWIST1 promoter CTD PMID:23974009 belinostat increases expression ISO RGD:1349130 6480464 belinostat results in increased expression of TWIST1 protein CTD PMID:23671600 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of TWIST1 mRNA CTD PMID:21839799 benzo[a]pyrene decreases expression ISO RGD:1553211 6480464 Benzo(a)pyrene results in decreased expression of TWIST1 mRNA CTD PMID:22610609 benzo[a]pyrene increases expression ISO RGD:1349130 6480464 Benzo(a)pyrene results in increased expression of TWIST1 mRNA, Benzo(a)pyrene results in increased expression of TWIST1 protein CTD PMID:24847786 bisphenol A increases methylation ISO RGD:1349130 6480464 bisphenol A results in increased methylation of TWIST1 gene CTD PMID:22576693 bisphenol A increases expression ISO RGD:1553211 6480464 bisphenol A results in increased expression of TWIST1 mRNA CTD PMID:30951980 bisphenol A multiple interactions ISO RGD:1553211 6480464 [bisphenol A co-treated with LIF protein] results in decreased expression of TWIST1 mRNA CTD PMID:30951980 bisphenol A affects methylation ISO RGD:1553211 6480464 bisphenol A affects the methylation of TWIST1 promoter CTD PMID:27334623 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of TWIST1 mRNA CTD PMID:25181051 , PMID:29323181 bisphenol A decreases expression ISO RGD:1349130 6480464 bisphenol A results in decreased expression of TWIST1 mRNA CTD PMID:22576693 , PMID:26363213 bisphenol F increases expression ISO RGD:1553211 6480464 bisphenol F results in increased expression of TWIST1 mRNA CTD PMID:30951980 cadmium dichloride increases expression ISO RGD:1553211 6480464 Cadmium Chloride results in increased expression of TWIST1 mRNA CTD PMID:20478370 cadmium dichloride affects expression ISO RGD:1349130 6480464 Cadmium Chloride affects the expression of TWIST1 mRNA CTD PMID:23828170 calcitriol decreases expression ISO RGD:1349130 6480464 Calcitriol results in decreased expression of TWIST1 mRNA CTD PMID:26485663 choline multiple interactions ISO RGD:1553211 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TWIST1 gene CTD PMID:20938992 chromium(6+) decreases expression ISO RGD:1349130 6480464 chromium hexavalent ion results in decreased expression of TWIST1 protein CTD PMID:23518002 cisplatin increases expression ISO RGD:1349130 6480464 Cisplatin results in increased expression of TWIST1 mRNA CTD PMID:21618587 cisplatin decreases expression ISO RGD:1349130 6480464 Cisplatin results in decreased expression of TWIST1 mRNA CTD PMID:27392435 cisplatin multiple interactions ISO RGD:1349130 6480464 U 0126 inhibits the reaction [Cisplatin results in increased expression of TWIST1 mRNA] CTD PMID:21618587 cobalt dichloride multiple interactions ISO RGD:1349130 6480464 cobaltous chloride results in increased expression of and affects the localization of TWIST1 protein, tetraethylenepentamine inhibits the reaction [cobaltous chloride results in increased expression of and affects the localization of TWIST1 protein] CTD PMID:26174737 coumestrol multiple interactions ISO RGD:1349130 6480464 [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of TWIST1 mRNA CTD PMID:19167446 crizotinib decreases response to substance ISO RGD:1349130 6480464 TWIST1 protein results in decreased susceptibility to crizotinib CTD PMID:22155737 dexamethasone increases expression ISO RGD:1349130 6480464 Dexamethasone results in increased expression of TWIST1 mRNA CTD PMID:25047013 diallyl trisulfide decreases expression ISO RGD:1349130 6480464 diallyl trisulfide results in decreased expression of TWIST1 protein CTD PMID:27566995 diallyl trisulfide multiple interactions ISO RGD:1349130 6480464 LDHA protein inhibits the reaction [diallyl trisulfide results in decreased expression of TWIST1 protein] CTD PMID:27566995 dioxygen increases expression ISO RGD:1349130 6480464 [Oxygen deficiency results in increased expression of CA9 mRNA] which results in increased expression of TWIST1 mRNA CTD PMID:26305601 dioxygen multiple interactions ISO RGD:1349130 6480464 CA9 mutant form inhibits the reaction [[Oxygen deficiency results in increased expression of CA9 mRNA] which results in increased expression of TWIST1 mRNA] CTD PMID:26305601 dorsomorphin multiple interactions ISO RGD:1349130 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 doxorubicin increases expression ISO RGD:1349130 6480464 Doxorubicin results in increased expression of TWIST1 mRNA CTD PMID:29803840 Enterolactone multiple interactions ISO RGD:1349130 6480464 [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of TWIST1 mRNA CTD PMID:19167446 erlotinib hydrochloride decreases response to substance ISO RGD:1553211 6480464 TWIST1 protein results in decreased susceptibility to Erlotinib Hydrochloride CTD PMID:30171258 erlotinib hydrochloride multiple interactions ISO RGD:1349130 6480464 [TWIST1 protein results in decreased susceptibility to Erlotinib Hydrochloride] which results in decreased cleavage of PARP1 protein, TWIST1 protein inhibits the reaction [Erlotinib Hydrochloride results in increased cleavage of PARP1 protein] CTD PMID:30171258 erlotinib hydrochloride decreases response to substance ISO RGD:1349130 6480464 TWIST1 protein results in decreased susceptibility to Erlotinib Hydrochloride CTD PMID:30171258 erlotinib hydrochloride increases expression ISO RGD:1553211 6480464 Erlotinib Hydrochloride results in increased expression of TWIST1 protein CTD PMID:30171258 erlotinib hydrochloride multiple interactions ISO RGD:1553211 6480464 [TWIST1 protein results in decreased susceptibility to Erlotinib Hydrochloride] which results in decreased cleavage of CASP3 protein CTD PMID:30171258 finasteride multiple interactions EXP 6480464 Finasteride inhibits the reaction [Testosterone results in increased expression of TWIST1 mRNA] CTD PMID:27866977 flurbiprofen decreases expression ISO RGD:1553211 6480464 Flurbiprofen results in decreased expression of TWIST1 mRNA CTD PMID:16949054 folic acid multiple interactions ISO RGD:1553211 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TWIST1 gene CTD PMID:20938992 fonofos increases methylation ISO RGD:1349130 6480464 Fonofos results in increased methylation of TWIST1 promoter CTD PMID:22847954 gefitinib affects response to substance ISO RGD:1349130 6480464 TWIST1 protein affects the susceptibility to Gefitinib CTD PMID:30993382 isobutanol multiple interactions ISO RGD:1349130 6480464 [[Gasoline co-treated with isobutyl alcohol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of TWIST1 mRNA CTD PMID:29432896 L-methionine multiple interactions ISO RGD:1553211 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TWIST1 gene CTD PMID:20938992 losartan multiple interactions ISO RGD:1553211 6480464 Losartan inhibits the reaction [AGT protein results in increased expression of TWIST1 protein] CTD PMID:28578904 losartan multiple interactions ISO RGD:1349130 6480464 Losartan inhibits the reaction [AGT protein results in increased expression of TWIST1 protein] CTD PMID:28578904 melatonin multiple interactions ISO RGD:1349130 6480464 TWIST1 protein affects the reaction [Melatonin results in decreased expression of PROM1 protein] CTD PMID:30421542 mercury dibromide increases expression ISO RGD:1349130 6480464 mercuric bromide results in increased expression of TWIST1 mRNA CTD PMID:26272509 mercury dibromide multiple interactions ISO RGD:1349130 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TWIST1 mRNA CTD PMID:27188386 methylmercury chloride increases expression ISO RGD:1349130 6480464 methylmercuric chloride results in increased expression of TWIST1 mRNA CTD PMID:28001369 N-ethyl-N-nitrosourea increases mutagenesis ISO RGD:1553211 6480464 Ethylnitrosourea results in increased mutagenesis of TWIST1 gene CTD PMID:16724327 N-methyl-N-nitrosourea multiple interactions EXP 6480464 [Methylnitrosourea co-treated with Testosterone] results in increased expression of TWIST1 mRNA, Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of TWIST1 mRNA] CTD PMID:25164625 Niclosamide decreases expression ISO RGD:1349130 6480464 Niclosamide results in decreased expression of TWIST1 protein CTD PMID:29480568 nicotine increases expression ISO RGD:1349130 6480464 Nicotine results in increased expression of TWIST1 mRNA CTD PMID:23219715 osimertinib decreases response to substance ISO RGD:1349130 6480464 TWIST1 protein results in decreased susceptibility to osimertinib CTD PMID:30171258 osimertinib affects response to substance ISO RGD:1349130 6480464 TWIST1 protein affects the susceptibility to osimertinib CTD PMID:30993382 osimertinib multiple interactions ISO RGD:1349130 6480464 [TWIST1 protein results in decreased susceptibility to osimertinib] which results in decreased cleavage of PARP1 protein, TWIST1 protein inhibits the reaction [osimertinib results in increased cleavage of PARP1 protein] CTD PMID:30171258 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of TWIST1 mRNA CTD PMID:25729387 p-chloromercuribenzoic acid multiple interactions ISO RGD:1349130 6480464 [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TWIST1 mRNA CTD PMID:27188386 Pachymic acid multiple interactions ISO RGD:1553211 6480464 pachymic acid analog inhibits the reaction [AGT protein results in increased expression of TWIST1 protein] CTD PMID:28578904 Pachymic acid multiple interactions ISO RGD:1349130 6480464 pachymic acid analog inhibits the reaction [AGT protein results in increased expression of TWIST1 protein] CTD PMID:28578904 panobinostat multiple interactions ISO RGD:1349130 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TWIST1 mRNA CTD PMID:27188386 panobinostat increases expression ISO RGD:1349130 6480464 panobinostat results in increased expression of TWIST1 mRNA CTD PMID:26272509 paracetamol increases expression ISO RGD:1553211 6480464 Acetaminophen results in increased expression of TWIST1 mRNA CTD PMID:17585979 parathion increases methylation ISO RGD:1349130 6480464 Parathion results in increased methylation of TWIST1 promoter CTD PMID:22847954 phenylmercury acetate increases expression ISO RGD:1349130 6480464 Phenylmercuric Acetate results in increased expression of TWIST1 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:1349130 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TWIST1 mRNA CTD PMID:27188386 pirinixic acid increases expression ISO RGD:1553211 6480464 pirinixic acid results in increased expression of TWIST1 mRNA CTD PMID:20813756 progesterone multiple interactions ISO RGD:1349130 6480464 [Progesterone co-treated with Estradiol] results in decreased expression of TWIST1 mRNA CTD PMID:17404688 , PMID:18692832 progesterone decreases expression ISO RGD:1349130 6480464 Progesterone results in decreased expression of TWIST1 mRNA CTD PMID:17404688 , PMID:18692832 quercetin multiple interactions EXP 6480464 Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of TWIST1 mRNA] CTD PMID:25164625 quercetin decreases expression ISO RGD:1349130 6480464 Quercetin results in decreased expression of TWIST1 protein CTD PMID:22422628 SB 203580 multiple interactions ISO RGD:1349130 6480464 SB 203580 inhibits the reaction [thymoquinone results in decreased expression of TWIST1 protein] CTD PMID:27060453 SB 431542 multiple interactions ISO RGD:1349130 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 sodium arsenite multiple interactions ISO RGD:1349130 6480464 EPAS1 mutant form inhibits the reaction [sodium arsenite results in increased expression of TWIST1 protein], sodium arsenite promotes the reaction [EPAS1 protein binds to TWIST1 promoter] CTD PMID:22662215 sodium arsenite increases expression ISO RGD:1349130 6480464 sodium arsenite results in increased expression of TWIST1 mRNA, sodium arsenite results in increased expression of TWIST1 protein CTD PMID:22662215 sorafenib decreases expression ISO RGD:1553211 6480464 sorafenib results in decreased expression of TWIST1 mRNA CTD PMID:21360571 Swertiamarin multiple interactions EXP 6480464 swertiamarin inhibits the reaction [Testosterone results in increased expression of TWIST1 mRNA] CTD PMID:27866977 terbufos increases methylation ISO RGD:1349130 6480464 terbufos results in increased methylation of TWIST1 promoter CTD PMID:22847954 testosterone multiple interactions EXP 6480464 [Methylnitrosourea co-treated with Testosterone] results in increased expression of TWIST1 mRNA more ... CTD PMID:25164625 , PMID:27866977 testosterone increases expression EXP 6480464 Testosterone results in increased expression of TWIST1 mRNA CTD PMID:27866977 tetraethylenepentamine decreases expression ISO RGD:1553211 6480464 tetraethylenepentamine results in decreased expression of TWIST1 protein CTD PMID:26174737 tetraethylenepentamine multiple interactions ISO RGD:1349130 6480464 tetraethylenepentamine inhibits the reaction [cobaltous chloride results in increased expression of and affects the localization of TWIST1 protein] CTD PMID:26174737 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of TWIST1 mRNA CTD PMID:25729387 tributylstannane multiple interactions ISO RGD:1553211 6480464 Tetrachlorodibenzodioxin promotes the reaction [tributyltin results in decreased expression of TWIST1 mRNA] CTD PMID:22749964 tributylstannane decreases expression ISO RGD:1553211 6480464 tributyltin results in decreased expression of TWIST1 mRNA CTD PMID:22749964 trichostatin A increases expression ISO RGD:1349130 6480464 trichostatin A results in increased expression of TWIST1 mRNA CTD PMID:24935251 , PMID:26272509 trichostatin A multiple interactions ISO RGD:1349130 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TWIST1 mRNA CTD PMID:27188386 undecane increases expression EXP 6480464 undecane results in increased expression of TWIST1 protein CTD PMID:17337753 valproic acid increases expression ISO RGD:1553211 6480464 Valproic Acid results in increased expression of TWIST1 mRNA CTD PMID:24896083 valproic acid increases expression ISO RGD:1349130 6480464 Valproic Acid results in increased expression of TWIST1 mRNA CTD PMID:23179753 more ... valproic acid multiple interactions ISO RGD:1349130 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TWIST1 mRNA CTD PMID:27188386 vorinostat increases expression ISO RGD:1349130 6480464 vorinostat results in increased expression of TWIST1 mRNA CTD PMID:26272509 zearalenone decreases expression ISO RGD:1349130 6480464 Zearalenone results in decreased expression of TWIST1 mRNA CTD PMID:28965971
Biological Process aortic valve morphogenesis ISO RGD:1553211 1624291 (MGI:MGI:4838344, PMID:20804746) RGD MGI:MGI:4838344 , PMID:20804746 aortic valve morphogenesis IEA UniProtKB:Q15672 , ensembl:ENSP000002422611600115 GO_REF:0000107 Ensembl GO_REF:0000107 aortic valve morphogenesis IEA UniProtKB:P26687 , ensembl:ENSMUSP000000400891600115 GO_REF:0000107 Ensembl GO_REF:0000107 aortic valve morphogenesis ISO RGD:1349130 1624291 (PMID:20804746) RGD PMID:20804746 bone development IEP 5131604 RGD cardiac neural crest cell development involved in outflow tract morphogenesis ISO RGD:1553211 1624291 MGI:MGI:1857265 (MGI:MGI:3805126 , PMID:18539270) RGD MGI:MGI:3805126 , PMID:18539270 cardiac neural crest cell migration involved in outflow tract morphogenesis ISO RGD:1553211 1624291 MGI:MGI:1857265 (MGI:MGI:3805126 , PMID:18539270) RGD MGI:MGI:3805126 , PMID:18539270 cardiac neural crest cell migration involved in outflow tract morphogenesis IEA UniProtKB:P26687 , ensembl:ENSMUSP000000400891600115 GO_REF:0000107 Ensembl GO_REF:0000107 cell differentiation ISO RGD:1553211 1624291 MGI:MGI:1857265 (MGI:MGI:2384366 , PMID:12142027) RGD MGI:MGI:2384366 , PMID:12142027 cell proliferation involved in heart valve development ISO RGD:1553211 1624291 (MGI:MGI:4838344, PMID:20804746) RGD MGI:MGI:4838344 , PMID:20804746 cell proliferation involved in heart valve development IEA UniProtKB:Q15672 , ensembl:ENSP000002422611600115 GO_REF:0000107 Ensembl GO_REF:0000107 cell proliferation involved in heart valve development IEA UniProtKB:P26687 , ensembl:ENSMUSP000000400891600115 GO_REF:0000107 Ensembl GO_REF:0000107 cell proliferation involved in heart valve development ISO RGD:1349130 1624291 (PMID:20804746) RGD PMID:20804746 cellular response to growth factor stimulus IEP 5131599 RGD cellular response to hypoxia ISO RGD:1553211 1624291 (MGI:MGI:5284765, PMID:18297062) RGD MGI:MGI:5284765 , PMID:18297062 cellular response to hypoxia IEA UniProtKB:Q15672 , ensembl:ENSP000002422611600115 GO_REF:0000107 Ensembl GO_REF:0000107 cellular response to hypoxia IEA UniProtKB:P26687 , ensembl:ENSMUSP000000400891600115 GO_REF:0000107 Ensembl GO_REF:0000107 cellular response to hypoxia ISO RGD:1349130 1624291 (PMID:18297062) RGD PMID:18297062 cranial suture morphogenesis ISO RGD:1553211 1624291 MGI:MGI:1857265 more ... RGD MGI:MGI:2387743 more ... cranial suture morphogenesis IEA UniProtKB:P26687 , ensembl:ENSMUSP000000400891600115 GO_REF:0000107 Ensembl GO_REF:0000107 embryonic camera-type eye formation ISO RGD:1349130 1624291 (PMID:17070479) RGD PMID:17070479 embryonic camera-type eye formation IEA UniProtKB:Q15672 , ensembl:ENSP000002422611600115 GO_REF:0000107 Ensembl GO_REF:0000107 embryonic cranial skeleton morphogenesis ISO RGD:1349130 1624291 (PMID:8988166), (PMID:8988167) RGD PMID:8988166 , PMID:8988167 embryonic cranial skeleton morphogenesis IEA UniProtKB:Q15672 , ensembl:ENSP000002422611600115 GO_REF:0000107 Ensembl GO_REF:0000107 embryonic cranial skeleton morphogenesis IEA UniProtKB:P26687 , ensembl:ENSMUSP000000400891600115 GO_REF:0000107 Ensembl GO_REF:0000107 embryonic cranial skeleton morphogenesis ISO RGD:1553211 1624291 MGI:MGI:99829 (MGI:MGI:1100098 more ... RGD MGI:MGI:1100098 more ... embryonic digit morphogenesis ISO RGD:1553211 1624291 MGI:MGI:3038818 (MGI:MGI:3042355 , PMID:15030764) RGD MGI:MGI:3042355 , PMID:15030764 embryonic digit morphogenesis IEA UniProtKB:P26687 , ensembl:ENSMUSP000000400891600115 GO_REF:0000107 Ensembl GO_REF:0000107 embryonic forelimb morphogenesis ISO RGD:1553211 1624291 MGI:MGI:1857265 (MGI:MGI:2180404 , PMID:12175489) RGD MGI:MGI:2180404 , PMID:12175489 embryonic forelimb morphogenesis IEA UniProtKB:P26687 , ensembl:ENSMUSP000000400891600115 GO_REF:0000107 Ensembl GO_REF:0000107 embryonic hindlimb morphogenesis ISO RGD:1553211 1624291 (MGI:MGI:1100098, PMID:8988167) RGD MGI:MGI:1100098 , PMID:8988167 embryonic hindlimb morphogenesis IEA UniProtKB:P26687 , ensembl:ENSMUSP000000400891600115 GO_REF:0000107 Ensembl GO_REF:0000107 embryonic limb morphogenesis ISO RGD:1553211 1624291 MGI:MGI:1857265 more ... RGD MGI:MGI:1934650 more ... embryonic skeletal system morphogenesis ISO RGD:1553211 1624291 MGI:MGI:3038818 (MGI:MGI:3042355 , PMID:15030764) RGD MGI:MGI:3042355 , PMID:15030764 endocardial cushion morphogenesis ISO RGD:1553211 1624291 MGI:MGI:1857265 (MGI:MGI:3805126 , PMID:18539270) RGD MGI:MGI:3805126 , PMID:18539270 endocardial cushion morphogenesis IEA UniProtKB:P26687 , ensembl:ENSMUSP000000400891600115 GO_REF:0000107 Ensembl GO_REF:0000107 eyelid development in camera-type eye ISO RGD:1349130 1624291 (PMID:17070479) RGD PMID:17070479 eyelid development in camera-type eye IEA UniProtKB:Q15672 , ensembl:ENSP000002422611600115 GO_REF:0000107 Ensembl GO_REF:0000107 hindlimb morphogenesis ISO RGD:1553211 1624291 MGI:MGI:2157489 (MGI:MGI:1353858 , PMID:10700192) RGD MGI:MGI:1353858 , PMID:10700192 in utero embryonic development ISO RGD:1553211 1624291 MGI:MGI:3038818 (MGI:MGI:3042355 , PMID:15030764) RGD MGI:MGI:3042355 , PMID:15030764 in utero embryonic development IEA UniProtKB:P26687 , ensembl:ENSMUSP000000400891600115 GO_REF:0000107 Ensembl GO_REF:0000107 mitral valve morphogenesis ISO RGD:1553211 1624291 (MGI:MGI:4838344, PMID:20804746) RGD MGI:MGI:4838344 , PMID:20804746 mitral valve morphogenesis IEA UniProtKB:P26687 , ensembl:ENSMUSP000000400891600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of apoptotic process IMP 5131599 RGD negative regulation of apoptotic process ISO RGD:1553211 1624291 MGI:MGI:1857265 (MGI:MGI:2180404 , PMID:12175489) RGD MGI:MGI:2180404 , PMID:12175489 negative regulation of apoptotic process IDA 634726 RGD negative regulation of cell differentiation ISO RGD:1553211 1624291 (MGI:MGI:1201268, PMID:9520323) RGD MGI:MGI:1201268 , PMID:9520323 negative regulation of cellular senescence ISO RGD:1349130 1624291 (PMID:17690110) RGD PMID:17690110 negative regulation of cellular senescence IEA UniProtKB:Q15672 , ensembl:ENSP000002422611600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of DNA damage response, signal transduction by p53 class mediator ISO RGD:1349130 1624291 (PMID:17690110) RGD PMID:17690110 negative regulation of DNA damage response, signal transduction by p53 class mediator IEA UniProtKB:Q15672 , ensembl:ENSP000002422611600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of DNA-binding transcription factor activity ISO RGD:1553211 1624291 (MGI:MGI:3843109, PMID:19345188) RGD MGI:MGI:3843109 , PMID:19345188 negative regulation of DNA-binding transcription factor activity IEA UniProtKB:P26687 , ensembl:ENSMUSP000000400891600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of double-strand break repair ISO RGD:1349130 1624291 (PMID:17690110) RGD PMID:17690110 negative regulation of double-strand break repair IEA UniProtKB:Q15672 , ensembl:ENSP000002422611600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of histone acetylation ISO RGD:1553211 1624291 (MGI:MGI:3843109, PMID:19345188) RGD MGI:MGI:3843109 , PMID:19345188 negative regulation of histone acetylation IEA UniProtKB:P26687 , ensembl:ENSMUSP000000400891600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of histone phosphorylation ISO RGD:1349130 1624291 (PMID:17690110) RGD PMID:17690110 negative regulation of histone phosphorylation IEA UniProtKB:Q15672 , ensembl:ENSP000002422611600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of molecular function ISO RGD:1553211 1624291 (MGI:MGI:3042355, PMID:15030764) RGD MGI:MGI:3042355 , PMID:15030764 negative regulation of osteoblast differentiation ISO RGD:1553211 1624291 (MGI:MGI:3042355, PMID:15030764) RGD MGI:MGI:3042355 , PMID:15030764 negative regulation of osteoblast differentiation IEA UniProtKB:Q15672 , ensembl:ENSP000002422611600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of osteoblast differentiation IEA UniProtKB:P26687 , ensembl:ENSMUSP000000400891600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of osteoblast differentiation ISO RGD:1349130 1624291 (PMID:16888803) RGD PMID:16888803 negative regulation of oxidative phosphorylation uncoupler activity ISO RGD:1553211 1624291 (MGI:MGI:3843109, PMID:19345188) RGD MGI:MGI:3843109 , PMID:19345188 negative regulation of oxidative phosphorylation uncoupler activity IEA UniProtKB:P26687 , ensembl:ENSMUSP000000400891600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of peroxisome proliferator activated receptor signaling pathway ISO RGD:1553211 1624291 (MGI:MGI:3843109, PMID:19345188) RGD MGI:MGI:3843109 , PMID:19345188 negative regulation of peroxisome proliferator activated receptor signaling pathway IEA UniProtKB:P26687 , ensembl:ENSMUSP000000400891600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of phosphatidylinositol 3-kinase signaling ISO RGD:1349130 1624291 (PMID:17003487) RGD PMID:17003487 negative regulation of phosphatidylinositol 3-kinase signaling IEA UniProtKB:Q15672 , ensembl:ENSP000002422611600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of skeletal muscle tissue development ISO RGD:1553211 1624291 (MGI:MGI:69156 more ... RGD MGI:MGI:69156 more ... negative regulation of skeletal muscle tissue development IEA UniProtKB:P26687 , ensembl:ENSMUSP000000400891600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of striated muscle tissue development ISO RGD:1553211 1624291 (MGI:MGI:1201268, PMID:9520323) RGD MGI:MGI:1201268 , PMID:9520323 negative regulation of transcription by RNA polymerase II ISO RGD:1349130 1624291 (PMID:17690110) RGD PMID:17690110 negative regulation of transcription by RNA polymerase II IEA UniProtKB:Q15672 , ensembl:ENSP000002422611600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of transcription by RNA polymerase II IEA UniProtKB:P26687 , ensembl:ENSMUSP000000400891600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of transcription by RNA polymerase II ISO RGD:1553211 1624291 (MGI:MGI:3623529 more ... RGD MGI:MGI:3623529 more ... negative regulation of transcription, DNA-templated ISO RGD:1349130 1624291 (PMID:25981568) RGD PMID:25981568 negative regulation of transcription, DNA-templated ISO RGD:1553211 1624291 (MGI:MGI:5559671, PMID:14645221) RGD MGI:MGI:5559671 , PMID:14645221 negative regulation of tumor necrosis factor production ISO RGD:1553211 1624291 MGI:MGI:104685 (MGI:MGI:3721468 , PMID:16831897) RGD MGI:MGI:3721468 , PMID:16831897 negative regulation of tumor necrosis factor production IEA UniProtKB:P26687 , ensembl:ENSMUSP000000400891600115 GO_REF:0000107 Ensembl GO_REF:0000107 neural tube closure ISO RGD:1553211 1624291 MGI:MGI:1857265 (MGI:MGI:72096 , PMID:7729687) RGD MGI:MGI:72096 , PMID:7729687 neural tube closure IEA UniProtKB:P26687 , ensembl:ENSMUSP000000400891600115 GO_REF:0000107 Ensembl GO_REF:0000107 neuron migration ISO RGD:1553211 1624291 MGI:MGI:1857265 (MGI:MGI:3042807 , PMID:15162501) RGD MGI:MGI:3042807 , PMID:15162501 neuron migration IEA UniProtKB:P26687 , ensembl:ENSMUSP000000400891600115 GO_REF:0000107 Ensembl GO_REF:0000107 odontogenesis IEP 5131603 RGD ossification ISO RGD:1553211 1624291 MGI:MGI:3038818 (MGI:MGI:3042355 , PMID:15030764) RGD MGI:MGI:3042355 , PMID:15030764 osteoblast differentiation ISO RGD:1553211 1624291 MGI:MGI:1857265 more ... RGD MGI:MGI:3042355 , PMID:15030764 osteoblast differentiation IEA UniProtKB:P26687 , ensembl:ENSMUSP000000400891600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of cell motility ISO RGD:1553211 1624291 (MGI:MGI:5284780, PMID:17332324) RGD MGI:MGI:5284780 , PMID:17332324 positive regulation of cell motility IEA UniProtKB:Q15672 , ensembl:ENSP000002422611600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of cell motility IEA UniProtKB:P26687 , ensembl:ENSMUSP000000400891600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of cell motility ISO RGD:1349130 1624291 (PMID:17332325) RGD PMID:17332325 positive regulation of DNA-templated transcription, initiation ISO RGD:1349130 1624291 (PMID:17332325) RGD PMID:17332325 positive regulation of DNA-templated transcription, initiation IEA UniProtKB:Q15672 , ensembl:ENSP000002422611600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation ISO RGD:1553211 1624291 (MGI:MGI:4838344, PMID:20804746) RGD MGI:MGI:4838344 , PMID:20804746 positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation IEA UniProtKB:P26687 , ensembl:ENSMUSP000000400891600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of epithelial cell proliferation IMP 5131601 RGD positive regulation of epithelial to mesenchymal transition ISO RGD:1349130 1624291 (PMID:18297062) RGD PMID:18297062 positive regulation of epithelial to mesenchymal transition ISO RGD:1553211 1624291 (MGI:MGI:4838344 more ... RGD MGI:MGI:4838344 more ... positive regulation of fatty acid beta-oxidation ISO RGD:1349130 1624291 (PMID:20007935) RGD PMID:20007935 positive regulation of fatty acid beta-oxidation IEA UniProtKB:Q15672 , ensembl:ENSP000002422611600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of gene expression ISO RGD:1349130 1624291 (PMID:17003487) RGD PMID:17003487 positive regulation of interleukin-6 secretion ISO RGD:1349130 1624291 (PMID:20007935) RGD PMID:20007935 positive regulation of interleukin-6 secretion IEA UniProtKB:Q15672 , ensembl:ENSP000002422611600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of monocyte chemotactic protein-1 production ISO RGD:1349130 1624291 (PMID:20007935) RGD PMID:20007935 positive regulation of monocyte chemotactic protein-1 production IEA UniProtKB:Q15672 , ensembl:ENSP000002422611600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of transcription by RNA polymerase II ISO RGD:1553211 1624291 (MGI:MGI:4457247 more ... RGD MGI:MGI:4457247 more ... positive regulation of transcription by RNA polymerase II IEA UniProtKB:Q15672 , ensembl:ENSP000002422611600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of transcription by RNA polymerase II IEA UniProtKB:P26687 , ensembl:ENSMUSP000000400891600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of transcription by RNA polymerase II ISO RGD:1349130 1624291 (PMID:12270142), (PMID:17332325) RGD PMID:12270142 , PMID:17332325 positive regulation of transcription regulatory region DNA binding ISO RGD:1349130 1624291 (PMID:12270142) RGD PMID:12270142 positive regulation of transcription regulatory region DNA binding IEA UniProtKB:Q15672 , ensembl:ENSP000002422611600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of tumor necrosis factor production ISO RGD:1349130 1624291 (PMID:20007935) RGD PMID:20007935 positive regulation of tumor necrosis factor production IEA UniProtKB:Q15672 , ensembl:ENSP000002422611600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of bone mineralization ISO RGD:1349130 1624291 (PMID:19597909) RGD PMID:19597909 regulation of bone mineralization IEA UniProtKB:Q15672 , ensembl:ENSP000002422611600115 GO_REF:0000107 Ensembl GO_REF:0000107 roof of mouth development IEP 5131603 RGD Cellular Component nucleus IDA 5131599 RGD nucleus ISO RGD:1349130 1624291 (PMID:10749989), (PMID:15545268) RGD PMID:10749989 , PMID:15545268 nucleus ISO RGD:1553211 1624291 (MGI:MGI:3783819, PMID:16100003) RGD MGI:MGI:3783819 , PMID:16100003 Molecular Function bHLH transcription factor binding ISO RGD:1349130 1624291 UniProtKB:P15923-1 (PMID:10749989) RGD PMID:10749989 bHLH transcription factor binding IEA UniProtKB:Q15672 , ensembl:ENSP000002422611600115 GO_REF:0000107 Ensembl GO_REF:0000107 DNA-binding transcription factor activity ISO RGD:1553211 1624291 (MGI:MGI:4457247, PMID:17893140) RGD MGI:MGI:4457247 , PMID:17893140 DNA-binding transcription factor activity, RNA polymerase II-specific ISO RGD:1349130 1624291 (PMID:17332325) RGD PMID:17332325 DNA-binding transcription factor activity, RNA polymerase II-specific IEA UniProtKB:Q15672 , ensembl:ENSP000002422611600115 GO_REF:0000107 Ensembl GO_REF:0000107 E-box binding ISO RGD:1349130 1624291 (PMID:17332325), (PMID:20804746) RGD PMID:17332325 , PMID:20804746 E-box binding IEA UniProtKB:Q15672 , ensembl:ENSP000002422611600115 GO_REF:0000107 Ensembl GO_REF:0000107 E-box binding IEA UniProtKB:P26687 , ensembl:ENSMUSP000000400891600115 GO_REF:0000107 Ensembl GO_REF:0000107 E-box binding ISO RGD:1553211 1624291 (MGI:MGI:3623529 more ... RGD MGI:MGI:3623529 more ... identical protein binding ISO RGD:1553211 1624291 UniProtKB:P26687 (MGI:MGI:3623529 , PMID:16502419) RGD MGI:MGI:3623529 , PMID:16502419 molecular_function ND 1598407 05/2011: no relevant rat data RGD protein binding ISO RGD:1553211 1624291 UniProtKB:P04637 more ... RGD MGI:MGI:5448103 more ... protein binding ISO RGD:1349130 1624291 UniProtKB:O60885 more ... RGD PMID:18504427 more ... protein binding ISO RGD:1553211 1624291 UniProtKB:P04637 more ... RGD MGI:MGI:3623529 more ... protein domain specific binding ISO RGD:1553211 1624291 UniProtKB:Q08775 (MGI:MGI:3042355 , PMID:15030764) RGD MGI:MGI:3042355 , PMID:15030764 protein domain specific binding IEA UniProtKB:P26687 , ensembl:ENSMUSP000000400891600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein heterodimerization activity ISO RGD:1553211 1624291 (MGI:MGI:3623529, PMID:16502419) RGD MGI:MGI:3623529 , PMID:16502419 protein heterodimerization activity IEA UniProtKB:P26687 , ensembl:ENSMUSP000000400891600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein homodimerization activity ISO RGD:1553211 1624291 (MGI:MGI:3623529, PMID:16502419) RGD MGI:MGI:3623529 , PMID:16502419 protein homodimerization activity IEA UniProtKB:P26687 , ensembl:ENSMUSP000000400891600115 GO_REF:0000107 Ensembl GO_REF:0000107 transcription factor binding ISO RGD:1553211 1624291 UniProtKB:O70343 (MGI:MGI:3843109 , PMID:19345188) RGD MGI:MGI:3843109 , PMID:19345188 transcription factor binding ISO RGD:1349130 1624291 UniProtKB:P20719 (PMID:15545268) RGD PMID:15545268
Gene-Chemical Interaction Annotations
