Grm5 (glutamate metabotropic receptor 5) - Rat Genome Database

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Gene: Grm5 (glutamate metabotropic receptor 5) Rattus norvegicus
Analyze
Symbol: Grm5
Name: glutamate metabotropic receptor 5
RGD ID: 2746
Description: Enables A2A adenosine receptor binding activity; glutamate receptor activity; and protein tyrosine kinase binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; positive regulation of long-term neuronal synaptic plasticity; and trans-synaptic signaling. Located in astrocyte projection; dendrite; and postsynaptic density membrane. Is integral component of postsynaptic membrane. Is active in glutamatergic synapse. Orthologous to human GRM5 (glutamate metabotropic receptor 5); PARTICIPATES IN calcium/calcium-mediated signaling pathway; glutamate signaling pathway; Huntington's disease pathway; INTERACTS WITH (+)-pilocarpine; (S)-3,5-dihydroxyphenylglycine; (S)-amphetamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: glutamate receptor, metabotropic 5; metabotropic glutamate receptor (mGluR5); metabotropic glutamate receptor 5; metabotropic glutamate receptor 5b; mGlur5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Grm5em1Sage  
Genetic Models: SD-Grm5em1Sage
Is Marker For: Strains:   FHH.BN-(D1Hmgc14-D1Hmgc15)/Mcwi  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21141,310,069 - 141,884,980 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1141,312,368 - 141,882,274 (+)Ensembl
Rnor_6.01151,207,846 - 151,785,038 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1151,439,409 - 151,783,392 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01157,517,676 - 158,096,869 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41143,857,225 - 144,477,419 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11143,935,630 - 144,555,825 (+)NCBI
Celera1139,643,467 - 140,193,665 (+)NCBICelera
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway  (IEA)
calcium-mediated signaling using intracellular calcium source  (IEA,ISO)
cellular response to amyloid-beta  (IEA,ISO)
chemical synaptic transmission  (IMP)
cognition  (ISO)
desensitization of G protein-coupled receptor signaling pathway  (IDA)
G protein-coupled glutamate receptor signaling pathway  (IBA,IEA,IMP,ISO,ISS)
G protein-coupled receptor signaling pathway  (IEA)
learning  (IEA,ISO)
learning or memory  (ISO)
locomotory behavior  (IEA,ISO)
modulation of age-related behavioral decline  (IEA,ISO)
negative regulation of locomotion  (IDA)
phosphatidylinositol-mediated signaling  (TAS)
phospholipase C-activating G protein-coupled glutamate receptor signaling pathway  (TAS)
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway  (TAS)
positive regulation of long-term neuronal synaptic plasticity  (IDA)
positive regulation of MAPK cascade  (IDA)
positive regulation of protein tyrosine kinase activity  (IEA,IGI,ISO)
postsynaptic modulation of chemical synaptic transmission  (IEA,ISO)
protein kinase C-activating G protein-coupled receptor signaling pathway  (IDA,TAS)
protein phosphorylation  (IDA)
regulation of intracellular calcium activated chloride channel activity  (IEA,ISO)
regulation of long-term neuronal synaptic plasticity  (IEA,ISO)
regulation of postsynaptic cytosolic calcium ion concentration  (IEA)
regulation of postsynaptic membrane potential  (IEA)
regulation of protein phosphorylation  (ISO)
regulation of synaptic transmission, glutamatergic  (IBA)
regulation of transcription, DNA-templated  (IDA)
regulation of translational elongation  (IEA,ISO)
synapse organization  (IEA,ISO)
trans-synaptic signaling by endocannabinoid, modulating synaptic transmission  (IBA,IMP)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Abe T, etal., J Biol Chem. 1992 Jul 5;267(19):13361-8.
2. Agassandian K and Cassell MD, Brain Res. 2008 Aug 21;1226:39-55. Epub 2008 Jun 11.
3. Cartmell J and Schoepp DD, J Neurochem. 2000 Sep;75(3):889-907.
4. Croci C, etal., J Biol Chem. 2003 Dec 12;278(50):50682-90. Epub 2003 Sep 30.
5. Domenici MR, etal., Eur J Neurosci 2003 May;17(10):2047-55.
6. Doria JG, etal., Br J Pharmacol. 2013 Jun;169(4):909-21. doi: 10.1111/bph.12164.
7. Doria JG, etal., Neurobiol Dis. 2015 Jan;73:163-73. doi: 10.1016/j.nbd.2014.08.021. Epub 2014 Aug 24.
8. Ferre S, etal., Proc Natl Acad Sci U S A 2002 Sep 3;99(18):11940-5.
9. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Gillard SE, etal., J Comp Neurol 2003 Jun 30;461(3):317-32.
11. GOA data from the GO Consortium
12. Gryder DS and Rogawski MA, J Neurosci 2003 Aug 6;23(18):7069-74.
13. Izumi Y and Zorumski CF, Neuropsychopharmacology. 2012 Feb;37(3):609-17. doi: 10.1038/npp.2011.243. Epub 2011 Oct 12.
14. Kotecha SA, etal., J Biol Chem 2003 Jul 25;278(30):27742-9.
15. Lavialle M, etal., Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):12915-9. doi: 10.1073/pnas.1100957108. Epub 2011 Jul 13.
16. Lujan R, etal., Eur J Neurosci. 1996 Jul;8(7):1488-500.
17. Luján R, etal., J Chem Neuroanat. 1997 Oct;13(4):219-41.
18. Mao L, etal., J Neurosci. 2005 Mar 9;25(10):2741-52.
19. MGD data from the GO Consortium
20. NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. Neugebauer V, etal., J Neurosci 2003 Jan 1;23(1):52-63.
22. Park JM, etal., Cell. 2013 Aug 1;154(3):637-50. doi: 10.1016/j.cell.2013.07.001.
23. Pipeline to import KEGG annotations from KEGG into RGD
24. Poisik OV, etal., J Neurosci 2003 Jan 1;23(1):122-30.
25. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. RGD automated import pipeline for gene-chemical interactions
27. Ribeiro FM, etal., Hum Mol Genet. 2014 Apr 15;23(8):2030-42. doi: 10.1093/hmg/ddt598. Epub 2013 Nov 26.
28. Schiefer J, etal., Brain Res. 2004 Sep 3;1019(1-2):246-54.
29. Servitja JM, etal., Neuropharmacology 2003 Feb;44(2):171-80.
30. Sgambato-Faure V, etal., Biochem Biophys Res Commun. 2006 May 5;343(2):630-7. Epub 2006 Mar 15.
31. Sorensen SD, etal., Mol Pharmacol. 2002 Jun;61(6):1303-12.
32. Sugi T, etal., EMBO J. 2007 Apr 18;26(8):2192-205. Epub 2007 Mar 29.
33. Um JW, etal., Neuron. 2013 Sep 4;79(5):887-902. doi: 10.1016/j.neuron.2013.06.036.
34. Wang H, etal., Science. 2009 Dec 11;326(5959):1554-7. doi: 10.1126/science.1178496.
Additional References at PubMed
PMID:7688218   PMID:7908515   PMID:9069287   PMID:9185557   PMID:9647694   PMID:9648851   PMID:9808458   PMID:9808459   PMID:10433269   PMID:10469171   PMID:10798399   PMID:11431513  
PMID:11595334   PMID:11850456   PMID:11943148   PMID:11973471   PMID:11986378   PMID:12077217   PMID:12176012   PMID:12529370   PMID:12562994   PMID:12646135   PMID:12660307   PMID:12716432  
PMID:12727324   PMID:12736269   PMID:12764131   PMID:12967992   PMID:14527949   PMID:14614082   PMID:14691258   PMID:14709549   PMID:15010207   PMID:15126034   PMID:15574735   PMID:15659214  
PMID:15661743   PMID:15777867   PMID:15882947   PMID:15893585   PMID:15894802   PMID:16024054   PMID:16153770   PMID:16280580   PMID:16289868   PMID:16302229   PMID:16436598   PMID:16836654  
PMID:16905160   PMID:17113328   PMID:17154259   PMID:17311919   PMID:17359492   PMID:17380680   PMID:17389377   PMID:17512115   PMID:17517168   PMID:17548216   PMID:17680995   PMID:17881561  
PMID:17937975   PMID:17998101   PMID:17998106   PMID:18065158   PMID:18185116   PMID:18242586   PMID:18469540   PMID:18554818   PMID:18621097   PMID:18715999   PMID:18716215   PMID:18816644  
PMID:18991866   PMID:19116182   PMID:19118598   PMID:19169252   PMID:19359367   PMID:19364772   PMID:19439188   PMID:19616571   PMID:19628026   PMID:19666081   PMID:19670629   PMID:19672584  
PMID:19694902   PMID:19840937   PMID:19860857   PMID:19864572   PMID:19894497   PMID:19903331   PMID:19961906   PMID:20043967   PMID:20056114   PMID:20058604   PMID:20151362   PMID:20177824  
PMID:20180987   PMID:20181581   PMID:20193665   PMID:20519363   PMID:20525770   PMID:20600666   PMID:20644995   PMID:20667449   PMID:20705895   PMID:20720114   PMID:20819696   PMID:20854878  
PMID:20864408   PMID:21150906   PMID:21218453   PMID:21300123   PMID:21319882   PMID:21384157   PMID:21486279   PMID:21731033   PMID:21795692   PMID:21880942   PMID:22015768   PMID:22034224  
PMID:22147256   PMID:22172929   PMID:22179607   PMID:22193724   PMID:22238580   PMID:22245498   PMID:22296815   PMID:22310150   PMID:22472649   PMID:22521775   PMID:22578356   PMID:22586220  
PMID:22617006   PMID:22652057   PMID:23022504   PMID:23137441   PMID:23227193   PMID:23376485   PMID:23444015   PMID:23616528   PMID:23978512   PMID:24032403   PMID:24050755   PMID:24373900  
PMID:24395787   PMID:24510777   PMID:24663806   PMID:24670218   PMID:24910241   PMID:24941251   PMID:25113912   PMID:25160592   PMID:25161282   PMID:25185819   PMID:25399651   PMID:25421413  
PMID:25449406   PMID:25451626   PMID:25497704   PMID:25627107   PMID:25739080   PMID:25778620   PMID:25810529   PMID:25885040   PMID:25894678   PMID:26033576   PMID:26071959   PMID:26095359  
PMID:26318863   PMID:26365953   PMID:26389591   PMID:26454081   PMID:26538661   PMID:26777117   PMID:26791214   PMID:26837579   PMID:26902516   PMID:26946431   PMID:27014856   PMID:27055771  
PMID:27211252   PMID:27357735   PMID:27531836   PMID:27542344   PMID:27618534   PMID:27721389   PMID:27744406   PMID:27822496   PMID:27871824   PMID:28019025   PMID:28433499   PMID:28455267  
PMID:28533177   PMID:28851991   PMID:29074619   PMID:29191654   PMID:29266405   PMID:29337350   PMID:30010864   PMID:30291225   PMID:30413218   PMID:30444177   PMID:30599269   PMID:30675062  
PMID:30758331   PMID:31008528   PMID:31119680   PMID:31161451   PMID:31202839   PMID:31369778   PMID:31404590   PMID:31597090   PMID:31600563   PMID:31710636   PMID:31830486   PMID:31891692  
PMID:32039920   PMID:32087111   PMID:32145272   PMID:32454125   PMID:32767063   PMID:32976802   PMID:33352285   PMID:34137089  


Genomics

Comparative Map Data
Grm5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21141,310,069 - 141,884,980 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1141,312,368 - 141,882,274 (+)Ensembl
Rnor_6.01151,207,846 - 151,785,038 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1151,439,409 - 151,783,392 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01157,517,676 - 158,096,869 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41143,857,225 - 144,477,419 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11143,935,630 - 144,555,825 (+)NCBI
Celera1139,643,467 - 140,193,665 (+)NCBICelera
Cytogenetic Map1q32NCBI
GRM5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1188,504,576 - 89,065,982 (-)EnsemblGRCh38hg38GRCh38
GRCh381188,504,576 - 89,065,982 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371188,237,810 - 88,799,150 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361187,880,626 - 88,420,838 (-)NCBINCBI36hg18NCBI36
Build 341187,880,625 - 88,420,838NCBI
Celera1185,835,181 - 86,394,276 (+)NCBI
Cytogenetic Map11q14.2-q14.3NCBI
HuRef1184,476,702 - 85,036,122 (-)NCBIHuRef
CHM1_11188,120,759 - 88,679,818 (-)NCBICHM1_1
Grm5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39787,233,212 - 87,784,271 (+)NCBIGRCm39mm39
GRCm39 Ensembl787,233,376 - 87,784,115 (+)Ensembl
GRCm38787,583,981 - 88,135,063 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl787,584,168 - 88,134,907 (+)EnsemblGRCm38mm10GRCm38
MGSCv37794,732,678 - 95,283,573 (+)NCBIGRCm37mm9NCBIm37
MGSCv36787,459,538 - 88,009,526 (+)NCBImm8
Celera784,945,210 - 85,487,922 (+)NCBICelera
Cytogenetic Map7D3NCBI
Grm5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554144,424,245 - 4,919,399 (+)NCBIChiLan1.0ChiLan1.0
GRM5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11187,103,730 - 87,658,987 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1187,107,788 - 87,868,953 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01183,514,978 - 84,077,650 (-)NCBIMhudiblu_PPA_v0panPan3
GRM5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12110,980,186 - 11,496,539 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2110,996,075 - 11,493,290 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2110,835,710 - 11,353,650 (+)NCBI
ROS_Cfam_1.02111,158,622 - 11,676,400 (+)NCBI
UMICH_Zoey_3.12110,948,659 - 11,467,273 (+)NCBI
UNSW_CanFamBas_1.02111,025,934 - 11,536,817 (+)NCBI
UU_Cfam_GSD_1.02111,072,936 - 11,589,092 (+)NCBI
Grm5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494774,278,623 - 74,719,419 (-)NCBI
SpeTri2.0NW_004936736623,118 - 1,060,273 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRM5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl921,916,815 - 22,436,063 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1921,914,422 - 22,438,200 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2924,418,550 - 24,660,127 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GRM5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1179,636,636 - 80,206,471 (-)NCBI
Vero_WHO_p1.0NW_02366604345,522,256 - 46,088,658 (+)NCBI
Grm5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248451,064,866 - 1,631,722 (+)NCBI

Position Markers
D1Hmgc13  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21141,875,982 - 141,876,303 (+)MAPPERmRatBN7.2
Rnor_6.01151,778,407 - 151,778,727NCBIRnor6.0
Rnor_5.01158,090,440 - 158,090,760UniSTSRnor5.0
RGSC_v3.41144,472,434 - 144,472,754UniSTSRGSC3.4
Cytogenetic Map1q32UniSTS
BF399922  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21141,715,625 - 141,715,844 (+)MAPPERmRatBN7.2
Rnor_6.01151,611,818 - 151,612,036NCBIRnor6.0
Rnor_5.01157,923,033 - 157,923,251UniSTSRnor5.0
RGSC_v3.41144,367,210 - 144,367,428UniSTSRGSC3.4
Celera1140,030,162 - 140,030,380UniSTS
RH 3.4 Map11113.3UniSTS
Cytogenetic Map1q32UniSTS
AI850523  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21141,882,118 - 141,882,273 (+)MAPPERmRatBN7.2
Rnor_6.01151,784,541 - 151,784,695NCBIRnor6.0
Rnor_5.01158,096,574 - 158,096,728UniSTSRnor5.0
RGSC_v3.41144,236,158 - 144,236,312UniSTSRGSC3.4
RGSC_v3.41144,478,568 - 144,478,722UniSTSRGSC3.4
Celera1140,194,815 - 140,194,969UniSTS
Cytogenetic Map1q32UniSTS
SGC30871  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21141,880,697 - 141,880,798 (+)MAPPERmRatBN7.2
Rnor_6.01151,783,120 - 151,783,220NCBIRnor6.0
Rnor_5.01158,095,153 - 158,095,253UniSTSRnor5.0
RGSC_v3.41144,477,147 - 144,477,247UniSTSRGSC3.4
Celera1140,193,393 - 140,193,493UniSTS
Cytogenetic Map1q32UniSTS
RH144288  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21141,881,141 - 141,881,300 (+)MAPPERmRatBN7.2
Rnor_6.01151,783,564 - 151,783,722NCBIRnor6.0
Rnor_5.01158,095,597 - 158,095,755UniSTSRnor5.0
RGSC_v3.41144,477,591 - 144,477,749UniSTSRGSC3.4
Celera1140,193,837 - 140,193,995UniSTS
RH 3.4 Map11115.1UniSTS
Cytogenetic Map1q32UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642722214537671Rat
61346Rf2Renal disease susceptibility QTL 23.7urine protein amount (VT:0005160)urine protein level (CMO:0000591)199267916144267916Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)199267916144267916Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
2303591Gluco41Glucose level QTL 412blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1102168504147168504Rat
61370Mcs3Mammary carcinoma susceptibility QTL 32.15mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1102268556147268556Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1102813953151162766Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1103111621148111621Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1103111621148111621Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1106047847151047847Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
2313060Bss71Bone structure and strength QTL 712.60.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1118944747163944747Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121833674166833674Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
631570Bp94Blood pressure QTL 940.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123479780142990467Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501168883176Rat
9685799Bp375Blood pressure QTL 375arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
9685802Bp376Blood pressure QTL 376arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1126540680171540680Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1131763437159756369Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1136745990163747690Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1136830018181830018Rat


Related Rat Strains
The following Strains have been annotated to Grm5


Genetic Models
This gene Grm5 is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:65
Count of miRNA genes:34
Interacting mature miRNAs:37
Transcripts:ENSRNOT00000022060, ENSRNOT00000050639
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system appendage
High
Medium 46
Low 1 18 8 1
Below cutoff 1 10 6 4 6 5 5 2 11 10 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000022060   ⟹   ENSRNOP00000022059
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1141,312,368 - 141,882,274 (+)Ensembl
Rnor_6.0 Ensembl1151,439,409 - 151,783,256 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000050639   ⟹   ENSRNOP00000040016
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1141,312,368 - 141,880,970 (+)Ensembl
Rnor_6.0 Ensembl1151,439,409 - 151,783,392 (+)Ensembl
RefSeq Acc Id: NM_017012   ⟹   NP_058708
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21141,321,129 - 141,880,970 (+)NCBI
Rnor_6.01151,218,929 - 151,783,392 (+)NCBI
Rnor_5.01157,517,676 - 158,096,869 (+)NCBI
RGSC_v3.41143,857,225 - 144,477,419 (+)RGD
Celera1139,643,467 - 140,193,665 (+)RGD
Sequence:
RefSeq Acc Id: XM_006229659   ⟹   XP_006229721
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21141,310,069 - 141,884,980 (+)NCBI
Rnor_6.01151,207,846 - 151,785,038 (+)NCBI
Rnor_5.01157,517,676 - 158,096,869 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017588778   ⟹   XP_017444267
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21141,310,069 - 141,884,980 (+)NCBI
Rnor_6.01151,207,846 - 151,785,038 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017588779   ⟹   XP_017444268
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21141,312,404 - 141,884,980 (+)NCBI
Rnor_6.01151,209,693 - 151,785,038 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017588780   ⟹   XP_017444269
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21141,312,404 - 141,884,980 (+)NCBI
Rnor_6.01151,209,693 - 151,785,038 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017588781   ⟹   XP_017444270
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21141,310,070 - 141,884,980 (+)NCBI
Rnor_6.01151,207,846 - 151,785,038 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039096032   ⟹   XP_038951960
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21141,310,069 - 141,884,980 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_058708   ⟸   NM_017012
- Peptide Label: precursor
- UniProtKB: P31424 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006229721   ⟸   XM_006229659
- Peptide Label: isoform X1
- UniProtKB: P31424 (UniProtKB/Swiss-Prot),   B2CZC8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017444267   ⟸   XM_017588778
- Peptide Label: isoform X1
- UniProtKB: P31424 (UniProtKB/Swiss-Prot),   B2CZC8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017444270   ⟸   XM_017588781
- Peptide Label: isoform X2
- UniProtKB: P31424 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017444268   ⟸   XM_017588779
- Peptide Label: isoform X1
- UniProtKB: P31424 (UniProtKB/Swiss-Prot),   B2CZC8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017444269   ⟸   XM_017588780
- Peptide Label: isoform X1
- UniProtKB: P31424 (UniProtKB/Swiss-Prot),   B2CZC8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000022059   ⟸   ENSRNOT00000022060
RefSeq Acc Id: ENSRNOP00000040016   ⟸   ENSRNOT00000050639
RefSeq Acc Id: XP_038951960   ⟸   XM_039096032
- Peptide Label: isoform X1
Protein Domains
G_PROTEIN_RECEP_F3_4

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BUF/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
DA/OlaHsd (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
F344/Stm (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FXLE16/Stm (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/FarMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrcAek (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrcAek (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrcAek (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
M520/NRrrcMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MWF/Hsd (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/OlalpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/RijCrl (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2746 AgrOrtholog
BIND 144395
Ensembl Genes ENSRNOG00000016429 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000022059 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000040016 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022060 UniProtKB/TrEMBL
  ENSRNOT00000050639 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.10.50.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ANF_lig-bd_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_9-Cys_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_9-Cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_mtglu_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_mtglu_rcpt_5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Metabotropic_Glu_rcpt_Homer-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peripla_BP_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24418 UniProtKB/Swiss-Prot
NCBI Gene 24418 ENTREZGENE
Pfam 7tm_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANF_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GluR_Homer-bdg UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NCD3G UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Grm5 PhenoGen
PRINTS GPCRMGR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MTABOTROPC5R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MTABOTROPICR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F3_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F3_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F3_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F3_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART GluR_Homer-bdg UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53822 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0H2UHN1_RAT UniProtKB/TrEMBL
  A0A0H2UHW6_RAT UniProtKB/TrEMBL
  B2CZC8 ENTREZGENE, UniProtKB/TrEMBL
  GRM5_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-13 Grm5  glutamate metabotropic receptor 5  Grm5  glutamate receptor, metabotropic 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Grm5  glutamate receptor, metabotropic 5      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression highly expressed in the striatal GABAergic efferent neurons 625594
gene_process acts synergistically with the adenosine A2a-receptor (Adora2a) to increase c-fos expression in striatal sections, counteracting phencyclidine-induced motor activation 625594