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Gene: Cyba (cytochrome b-245 alpha chain) Rattus norvegicus
Symbol: Cyba
Name: cytochrome b-245 alpha chain
RGD ID: 620573
Description: Contributes to superoxide-generating NAD(P)H oxidase activity. Involved in several processes, including cellular response to gamma radiation; cellular response to organonitrogen compound; and positive regulation of cell population proliferation. Localizes to several cellular components, including NADPH oxidase complex; focal adhesion; and stress fiber. Colocalizes with perinuclear endoplasmic reticulum. Used to study hypertension and pulmonary hypertension. Biomarker of diabetic retinopathy; end stage renal disease; hypertension; and myocardial infarction. Human ortholog(s) of this gene implicated in artery disease (multiple); asthma; chronic obstructive pulmonary disease; and phagocyte bactericidal dysfunction (multiple). Orthologous to human CYBA (cytochrome b-245 alpha chain); PARTICIPATES IN thyroid hormone biosynthetic pathway; Leishmaniasis pathway; phagocytosis pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate.
Type: protein-coding
Also known as: alpha-subunit p22; cytochrome b(558) alpha chain; cytochrome b-245 light chain; cytochrome b-245, alpha polypeptide; cytochrome b558 alpha-subunit; cytochrome b558 subunit alpha; neutrophil cytochrome b 22 kDa polypeptide; p22 phagocyte B-cytochrome; p22-phox; p22phox; Phox; superoxide-generating NADPH oxidase light chain subunit
Homo sapiens (human) : CYBA (cytochrome b-245 alpha chain)  HGNC  Alliance
Mus musculus (house mouse) : Cyba (cytochrome b-245, alpha polypeptide)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : LOC102004641 (cytochrome b-245 light chain)
Pan paniscus (bonobo/pygmy chimpanzee) : LOC100986914 (cytochrome b-245 light chain)
Canis lupus familiaris (dog) : CYBA (cytochrome b-245 alpha chain)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101967032 (cytochrome b-245 light chain)
Sus scrofa (pig) : CYBA (cytochrome b-245 alpha chain)
Chlorocebus sabaeus (African green monkey) : LOC103233451 (cytochrome b-245 light chain)
Heterocephalus glaber (naked mole-rat) : LOC101717043 (cytochrome b-245 light chain)
more info ...
Allele / Splice: Cybaem1Mcwi   Cybam1Sdi  
Genetic Models: MES/Slc SS-Cybaem1Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01955,249,634 - 55,257,824 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1955,249,616 - 55,257,876 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01965,959,818 - 65,967,224 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41952,713,150 - 52,721,609 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11952,718,030 - 52,726,490 (-)NCBI
Celera1949,727,142 - 49,735,154 (-)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Cyba
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620573
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.