Cyba (cytochrome b-245 alpha chain) - Rat Genome Database

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Gene: Cyba (cytochrome b-245 alpha chain) Rattus norvegicus
Symbol: Cyba
Name: cytochrome b-245 alpha chain
RGD ID: 620573
Description: Contributes to superoxide-generating NAD(P)H oxidase activity. Involved in several processes, including cellular response to gamma radiation; cellular response to organonitrogen compound; and positive regulation of cell population proliferation. Located in several cellular components, including apical plasma membrane; focal adhesion; and stress fiber. Part of NADPH oxidase complex. Colocalizes with perinuclear endoplasmic reticulum. Used to study hypertension and pulmonary hypertension. Biomarker of diabetic retinopathy; end stage renal disease; hypertension; and myocardial infarction. Human ortholog(s) of this gene implicated in artery disease (multiple); asthma; chronic obstructive pulmonary disease; and phagocyte bactericidal dysfunction (multiple). Orthologous to human CYBA (cytochrome b-245 alpha chain); PARTICIPATES IN thyroid hormone biosynthetic pathway; Leishmaniasis pathway; phagocytosis pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: alpha-subunit p22; cytochrome b(558) alpha chain; cytochrome b-245 light chain; cytochrome b-245, alpha polypeptide; cytochrome b558 alpha-subunit; cytochrome b558 subunit alpha; neutrophil cytochrome b 22 kDa polypeptide; p22 phagocyte B-cytochrome; p22-phox; p22phox; Phox; superoxide-generating NADPH oxidase light chain subunit
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Cybaem1Mcwi   Cybam1Sdi  
Genetic Models: SS-Cybaem1Mcwi MES/Slc
Candidate Gene For: Eau8
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81967,396,143 - 67,404,214 (-)NCBIGRCr8
mRatBN7.21950,487,598 - 50,495,669 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1950,487,597 - 50,495,721 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1957,282,778 - 57,290,847 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01957,962,531 - 57,970,602 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01960,181,396 - 60,189,465 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01955,249,634 - 55,257,824 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1955,249,616 - 55,257,876 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01965,959,818 - 65,967,224 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41952,713,150 - 52,721,609 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11952,718,030 - 52,726,490 (-)NCBI
Celera1949,727,142 - 49,735,154 (-)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(R)-lipoic acid  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-naphthyl isothiocyanate  (EXP)
11-deoxycorticosterone  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-hydroxypropanoic acid  (ISO)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-TEMPO  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
AICA ribonucleotide  (EXP)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
aminoguanidine  (EXP)
amlodipine  (EXP)
ammonium chloride  (EXP)
anagliptin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antirheumatic drug  (ISO)
apocynin  (EXP,ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (EXP)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (ISO)
bezafibrate  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bortezomib  (ISO)
butan-1-ol  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (EXP)
candesartan  (EXP,ISO)
canrenoic acid  (EXP)
carbamazepine  (EXP)
carbon nanotube  (ISO)
chloropicrin  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
clothianidin  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cytarabine  (ISO)
D-glucose  (EXP,ISO)
daunorubicin  (EXP)
decabromodiphenyl ether  (EXP)
dehydroepiandrosterone  (EXP)
Deoxycorticosterone acetate  (ISO)
dextran sulfate  (ISO)
Di-n-octyl phthalate  (ISO)
diallyl trisulfide  (EXP)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibenziodolium  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
diethyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
enalapril  (ISO)
endosulfan  (EXP)
eplerenone  (EXP)
ethanol  (EXP,ISO)
farrerol  (EXP)
fenamidone  (ISO)
flavonoids  (ISO)
folic acid  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
ginsenoside Re  (ISO)
glucose  (EXP,ISO)
GW 6471  (EXP)
hexadecanoic acid  (EXP)
hydrochlorothiazide  (EXP)
hydrogen chloride  (ISO)
hydrogen peroxide  (EXP,ISO)
iron dextran  (EXP)
isobutanol  (ISO)
isoprenaline  (EXP)
ketamine  (ISO)
ketoconazole  (EXP)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
Lasiocarpine  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (ISO)
liraglutide  (ISO)
loganin  (ISO)
lutein  (ISO)
manidipine  (ISO)
menadione  (ISO)
mercury dichloride  (EXP)
metformin  (EXP,ISO)
methanol  (ISO)
methyl methanesulfonate  (ISO)
methylglyoxal  (ISO)
methylmercury chloride  (ISO)
Morroniside  (ISO)
N-acetyl-L-cysteine  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (EXP)
N-Nitrosopyrrolidine  (ISO)
naringin  (ISO)
nebivolol  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nicotinamide  (EXP)
nicotinic acid  (EXP)
O-methyleugenol  (ISO)
ochratoxin A  (EXP,ISO)
olmesartan  (EXP)
oxalic acid  (ISO)
oxycodone  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
paricalcitol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phencyclidine  (ISO)
phenethyl caffeate  (EXP)
phenol  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pravastatin  (EXP)
probenecid  (ISO)
progesterone  (ISO)
quercetin  (EXP,ISO)
rac-lactic acid  (ISO)
ramipril  (ISO)
reactive oxygen species  (EXP)
resveratrol  (EXP,ISO)
rosuvastatin calcium  (EXP)
rotenone  (EXP,ISO)
SB 203580  (ISO)
silicon dioxide  (EXP)
simvastatin  (ISO)
sirolimus  (EXP)
sirtinol  (EXP)
sodium arsenite  (EXP,ISO)
sodium chloride  (EXP,ISO)
sodium fluoride  (ISO)
Soman  (EXP)
streptozocin  (EXP)
sunitinib  (ISO)
superoxide  (EXP,ISO)
tacrolimus hydrate  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
tebuconazole  (ISO)
telmisartan  (EXP,ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trandolapril  (EXP)
triphenyl phosphate  (EXP)
triphenylstannane  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to amino acid stimulus  (IEP)
cellular response to angiotensin  (IEP)
cellular response to gamma radiation  (IEP)
cellular response to glucose stimulus  (IEP)
cellular response to L-glutamine  (IEP)
cellular response to mechanical stimulus  (IEP)
cellular response to organic cyclic compound  (IEP)
cellular response to organic substance  (IDA)
cellular response to tumor necrosis factor  (IEP)
cytochrome complex assembly  (IEA,ISO)
establishment of localization in cell  (IEA,ISO)
hydrogen peroxide biosynthetic process  (IMP)
inflammatory response  (IEA,ISO)
innate immune response  (IEA,ISO,ISS)
mucus secretion  (IEA,ISO)
negative regulation of glomerular filtration by angiotensin  (IMP)
positive regulation of blood pressure  (IMP)
positive regulation of cell growth  (IMP)
positive regulation of defense response to bacterium  (IEA,ISO)
positive regulation of endothelial cell proliferation  (IMP)
positive regulation of interleukin-6 production  (IEA,ISO)
positive regulation of mucus secretion  (IEA,ISO)
positive regulation of NAD(P)H oxidase activity  (IMP)
positive regulation of oxygen metabolic process  (ISO)
positive regulation of phagocytosis  (IEA,ISO)
positive regulation of reactive oxygen species biosynthetic process  (IEA,ISO)
positive regulation of smooth muscle cell proliferation  (IMP)
positive regulation of superoxide anion generation  (IMP)
positive regulation of toll-like receptor 2 signaling pathway  (IEA,ISO)
positive regulation of tumor necrosis factor production  (IEA,ISO)
reactive oxygen species metabolic process  (ISO)
regulation of release of sequestered calcium ion into cytosol  (IEA,ISO)
respiratory burst  (IEA,ISO)
response to activity  (IEP)
response to aldosterone  (IEP)
response to hypoxia  (IEP)
response to interleukin-1  (IEP)
response to nutrient levels  (IEP)
response to xenobiotic stimulus  (IEP)
smooth muscle hypertrophy  (IMP)
superoxide anion generation  (IBA,IEA,IMP,ISO)
superoxide metabolic process  (IDA,IMP,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References - curated
# Reference Title Reference Citation
1. Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase. Ambasta RK, etal., J Biol Chem. 2004 Oct 29;279(44):45935-41. Epub 2004 Aug 18.
2. Coronary microvascular endothelial cell growth regulates expression of the gene encoding p22-phox. Bayraktutan U Free Radic Biol Med. 2005 Nov 15;39(10):1342-52. Epub 2005 Aug 29.
3. Nitric oxide synthase and NAD(P)H oxidase modulate coronary endothelial cell growth. Bayraktutan U J Mol Cell Cardiol. 2004 Feb;36(2):277-86.
4. Molecular characterization and localization of the NAD(P)H oxidase components gp91-phox and p22-phox in endothelial cells. Bayraktutan U, etal., Arterioscler Thromb Vasc Biol 2000 Aug;20(8):1903-11.
5. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
6. Expression of two temporally distinct microglia-related gene clusters after spinal cord injury. Byrnes KR, etal., Glia. 2006 Mar;53(4):420-33.
7. Inhibition of superoxide anion generation by CHS-111 via blockade of the p21-activated kinase, protein kinase B/Akt and protein kinase C signaling pathways in rat neutrophils. Chang LC, etal., Eur J Pharmacol. 2009 Aug 1;615(1-3):207-17. Epub 2009 May 13.
9. NADPH oxidase mediates radiation-induced oxidative stress in rat brain microvascular endothelial cells. Collins-Underwood JR, etal., Free Radic Biol Med. 2008 Sep 15;45(6):929-38. Epub 2008 Jun 30.
10. The role of NOX2 and "novel oxidases" in airway chemoreceptor O(2) sensing. Cutz E, etal., Adv Exp Med Biol. 2009;648:427-38.
11. Cytochrome b558-negative, autosomal recessive chronic granulomatous disease: two new mutations in the cytochrome b558 light chain of the NADPH oxidase (p22-phox). de Boer M, etal., Am J Hum Genet. 1992 Nov;51(5):1127-35.
12. Tumour necrosis factor alpha activates a p22phox-based NADH oxidase in vascular smooth muscle. De Keulenaer GW, etal., Biochem J. 1998 Feb 1;329 ( Pt 3):653-7.
13. Oxidative stress contributes to pulmonary hypertension in the transgenic (mRen2)27 rat. DeMarco VG, etal., Am J Physiol Heart Circ Physiol. 2008 Jun;294(6):H2659-68. Epub 2008 Apr 18.
14. Human neutrophil cytochrome b light chain (p22-phox). Gene structure, chromosomal location, and mutations in cytochrome-negative autosomal recessive chronic granulomatous disease. Dinauer MC, etal., J Clin Invest 1990 Nov;86(5):1729-37.
15. Expression of p22-phox and gp91-phox, essential components of NADPH oxidase, increases after myocardial infarction. Fukui T, etal., Biochem Biophys Res Commun. 2001 Mar;281(5):1200-6.
16. Cytochrome b-558 alpha-subunit cloning and expression in rat aortic smooth muscle cells. Fukui T, etal., Biochim Biophys Acta 1995 Oct 10;1231(3):215-9.
17. Role of kallistatin in prevention of cardiac remodeling after chronic myocardial infarction. Gao L, etal., Lab Invest. 2008 Nov;88(11):1157-66. Epub 2008 Sep 1.
18. The p22 phox A640G gene polymorphism but not the C242T gene variation is associated with coronary heart disease in younger individuals. Gardemann A, etal., Atherosclerosis. 1999 Aug;145(2):315-23.
19. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
20. Subcellular localization of nicotinamide adenine dinucleotide phosphate oxidase subunits in neurons and astroglia of the rat medial nucleus tractus solitarius: relationship with tyrosine hydroxylase immunoreactive neurons. Glass MJ, etal., Neuroscience. 2006 Dec 1;143(2):547-64. Epub 2006 Oct 4.
21. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
22. Fluvastatin reverses endothelial dysfunction and increased vascular oxidative stress in rat adjuvant-induced arthritis. Haruna Y, etal., Arthritis Rheum. 2007 Jun;56(6):1827-35.
23. Acute effects of desmin mutations on cytoskeletal and cellular integrity in cardiac myocytes. Haubold K, etal., Cell Motil Cytoskeleton. 2003 Feb;54(2):105-21.
24. [Expression of WAVE1 and p22phox in children with acute lymphocytic leukemia and the relationship of WAVE1 with oxidative stress]. He YL, etal., Zhongguo Dang Dai Er Ke Za Zhi. 2009 Feb;11(2):88-92.
25. Synergistic effect of mechanical stretch and angiotensin II on superoxide production via NADPH oxidase in vascular smooth muscle cells. Hitomi H, etal., J Hypertens. 2006 Jun;24(6):1089-95.
26. Regulation of hypothalamic renin-angiotensin system and oxidative stress by aldosterone. Huang BS, etal., Exp Physiol. 2011 Oct;96(10):1028-38. doi: 10.1113/expphysiol.2011.059840. Epub 2011 Aug 8.
27. Haplotype analysis of the NADPH oxidase p22 phox gene in patients with bronchial asthma. Izakovicova Holla L, etal., Int Arch Allergy Immunol. 2009;148(1):73-80. Epub 2008 Aug 21.
28. p22phox-derived superoxide mediates enhanced proliferative capacity of diabetic vascular smooth muscle cells. Jeong HY, etal., Diabetes Res Clin Pract. 2004 Apr;64(1):1-10.
29. Increased superoxide anion production by interleukin-1beta impairs nitric oxide-mediated relaxation in resistance arteries. Jimenez-Altayo F, etal., J Pharmacol Exp Ther. 2006 Jan;316(1):42-52. Epub 2005 Sep 23.
30. Role of AT1 receptors and NAD(P)H oxidase in diabetes-aggravated ischemic brain injury. Kusaka I, etal., Am J Physiol Heart Circ Physiol. 2004 Jun;286(6):H2442-51.
31. Genetic polymorphisms and susceptibility to lung disease. Lee PL, etal., J Negat Results Biomed. 2006 Apr 11;5:5.
32. Relationship between reduced nicotinamide adenine dinucleotide phosphate oxidase subunit p22phox gene polymorphism and obstructive sleep apnea-hypopnea syndrome in the Chinese Han population. Liu HG, etal., Chin Med J (Engl). 2009 Jun 20;122(12):1369-74.
33. [Nicotinamide-adenine dinucleotide phosphate oxidase p22phox expression in induced sputum cells for patients with obstructive sleep apnea hypopnea syndrome.] Liu HG, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2010 Feb;33(2):118-22.
34. Poldip2, a novel regulator of Nox4 and cytoskeletal integrity in vascular smooth muscle cells. Lyle AN, etal., Circ Res. 2009 Jul 31;105(3):249-59. doi: 10.1161/CIRCRESAHA.109.193722. Epub 2009 Jul 2.
35. Relation between development of nephropathy and the p22phox C242T and receptor for advanced glycation end product G1704T gene polymorphisms in type 2 diabetic patients. Matsunaga-Irie S, etal., Diabetes Care. 2004 Feb;27(2):303-7.
36. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
37. RNA silencing in vivo reveals role of p22phox in rat angiotensin slow pressor response. Modlinger P, etal., Hypertension. 2006 Feb;47(2):238-44. Epub 2006 Jan 3.
38. Preliminary characterisation of the promoter of the human p22(phox) gene: identification of a new polymorphism associated with hypertension. Moreno MU, etal., FEBS Lett. 2003 May 8;542(1-3):27-31.
39. Pivotal Advance: Eosinophilia in the MES rat strain is caused by a loss-of-function mutation in the gene for cytochrome b(-245), alpha polypeptide (Cyba). Mori M, etal., J Leukoc Biol. 2009 Sep;86(3):473-8. doi: 10.1189/jlb.1108715. Epub 2009 Apr 30.
40. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
41. The role of NADPH oxidase in chronic intermittent hypoxia-induced pulmonary hypertension in mice. Nisbet RE, etal., Am J Respir Cell Mol Biol. 2009 May;40(5):601-9. Epub 2008 Oct 23.
42. p22phox in the macula densa regulates single nephron GFR during angiotensin II infusion in rats. Nouri P, etal., Am J Physiol Heart Circ Physiol. 2007 Apr;292(4):H1685-9. Epub 2007 Jan 12.
43. Apocynin restores endothelial dysfunction in streptozotocin diabetic rats through regulation of nitric oxide synthase and NADPH oxidase expressions. Olukman M, etal., J Diabetes Complications. 2010 Mar 10.
44. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
45. Tumor necrosis factor-alpha induces endothelial dysfunction in the prediabetic metabolic syndrome. Picchi A, etal., Circ Res. 2006 Jul 7;99(1):69-77. Epub 2006 Jun 1.
46. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
47. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
48. Glutamine plays a role in superoxide production and the expression of p47phox, p22phox and gp91phox in rat neutrophils. Pithon-Curi TC, etal., Clin Sci (Lond). 2002 Oct;103(4):403-8.
49. [Polymorphism -930A > G of the cytochrome b gene is a novel genetic marker of predisposition to bronchial asthma] Polonikov AV, etal., Ter Arkh. 2009;81(3):31-5.
50. GOA pipeline RGD automated data pipeline
51. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
52. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
53. Asymmetric dimethylarginine in angiotensin II-induced hypertension. Sasser JM, etal., Am J Physiol Regul Integr Comp Physiol. 2010 Mar;298(3):R740-6. Epub 2009 Dec 16.
54. Possible role of exogenous cAMP to improve vascular endothelial dysfunction in hypertensive rats. Shah DI and Singh M, Fundam Clin Pharmacol. 2006 Dec;20(6):595-604.
55. Association of gene polymorphisms with coronary artery disease in individuals with or without nonfamilial hypercholesterolemia. Shimokata K, etal., Atherosclerosis. 2004 Jan;172(1):167-73.
56. Characterization of six novel mutations in CYBA: the gene causing autosomal recessive chronic granulomatous disease. Teimourian S, etal., Br J Haematol. 2008 Jun;141(6):848-51. Epub 2008 Apr 18.
57. BN.MES-Cyba(mes) congenic rats manifest focal necrosis with eosinophilic infiltration in the liver without blood eosinophilia. Tomozawa H, etal., Exp Anim. 2010;59(4):469-78.
58. Genes for difference in eosinophilic phenotype between MES and BN.MES-Cyba(mes) rats are on chromosomes 9, 5, and 1. Tomozawa H, etal., Exp Anim. 2011;60(2):151-60.
59. p22phox is a critical component of the superoxide-generating NADH/NADPH oxidase system and regulates angiotensin II-induced hypertrophy in vascular smooth muscle cells. Ushio-Fukai M, etal., J Biol Chem. 1996 Sep 20;271(38):23317-21.
60. CYP1A1, CYP1A2 and CYBA gene polymorphisms associated with oxidative stress in COPD. Vibhuti A, etal., Clin Chim Acta. 2010 Apr 2;411(7-8):474-80. Epub 2010 Jan 18.
61. High glucose mediates pro-oxidant and antioxidant enzyme activities in coronary endothelial cells. Weidig P, etal., Diabetes Obes Metab. 2004 Nov;6(6):432-41.
62. Rosiglitazone prevents high glucose-induced vascular endothelial growth factor and collagen IV expression in cultured mesangial cells. Whiteside C, etal., Exp Diabetes Res. 2009;2009:910783. Epub 2009 Jul 7.
63. [Effect of danzhi jiangtang capsule combined exercise on the protein expression of NADPH oxidase p22phox in pancreatic tissues of diabetic rats]. Wu YJ, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2013 May;33(5):641-5.
64. Genetic studies of three Japanese patients with p22-phox-deficient chronic granulomatous disease: detection of a possible common mutant CYBA allele in Japan and a genotype-phenotype correlation in these patients. Yamada M, etal., Br J Haematol. 2000 Mar;108(3):511-7.
65. Homocysteine enhances TIMP-1 expression and cell proliferation associated with NADH oxidase in rat mesangial cells. Yang ZZ and Zou AP, Kidney Int. 2003 Mar;63(3):1012-20.
66. Protective role of pigment epithelium-derived factor (PEDF) in early phase of experimental diabetic retinopathy. Yoshida Y, etal., Diabetes Metab Res Rev. 2009 Oct;25(7):678-86.
67. High dietary fat induces NADPH oxidase-associated oxidative stress and inflammation in rat cerebral cortex. Zhang X, etal., Exp Neurol. 2005 Feb;191(2):318-25.
68. Effects of various degrees of oxidative stress induced by intermittent hypoxia in rat myocardial tissues. Zhou W, etal., Respirology. 2012 Jul;17(5):821-9. doi: 10.1111/j.1440-1843.2012.02157.x.
Additional References at PubMed
PMID:1763037   PMID:3305576   PMID:7938008   PMID:12042318   PMID:14651853   PMID:15123630   PMID:15850784   PMID:15851618   PMID:16115038   PMID:17085464   PMID:17698723   PMID:19246278  
PMID:19805644   PMID:19946888   PMID:21419083   PMID:21429415   PMID:21691064   PMID:22423966   PMID:22873349   PMID:23446743   PMID:23585488   PMID:23624755   PMID:24185898   PMID:24580748  
PMID:24739962   PMID:26389812   PMID:27824157   PMID:28351984   PMID:28669019   PMID:31030942   PMID:35786680  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81967,396,143 - 67,404,214 (-)NCBIGRCr8
mRatBN7.21950,487,598 - 50,495,669 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1950,487,597 - 50,495,721 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1957,282,778 - 57,290,847 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01957,962,531 - 57,970,602 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01960,181,396 - 60,189,465 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01955,249,634 - 55,257,824 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1955,249,616 - 55,257,876 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01965,959,818 - 65,967,224 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41952,713,150 - 52,721,609 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11952,718,030 - 52,726,490 (-)NCBI
Celera1949,727,142 - 49,735,154 (-)NCBICelera
Cytogenetic Map19q12NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381688,643,289 - 88,651,053 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1688,643,275 - 88,651,083 (-)EnsemblGRCh38hg38GRCh38
GRCh371688,709,697 - 88,717,461 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361687,237,198 - 87,244,958 (-)NCBINCBI36Build 36hg18NCBI36
Build 341687,237,198 - 87,244,950NCBI
Celera1673,779,369 - 73,787,129 (-)NCBICelera
Cytogenetic Map16q24.2NCBI
HuRef1674,403,728 - 74,411,523 (-)NCBIHuRef
CHM1_11690,120,999 - 90,128,842 (-)NCBICHM1_1
T2T-CHM13v2.01694,711,169 - 94,718,983 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm398123,151,510 - 123,159,679 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8123,151,515 - 123,159,669 (-)EnsemblGRCm39 Ensembl
GRCm388122,424,771 - 122,432,940 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8122,424,776 - 122,432,930 (-)EnsemblGRCm38mm10GRCm38
MGSCv378124,948,671 - 124,956,840 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368125,310,866 - 125,319,017 (-)NCBIMGSCv36mm8
Celera8126,653,882 - 126,662,049 (-)NCBICelera
Cytogenetic Map8E1NCBI
cM Map871.04NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049555412,569,727 - 2,574,118 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555412,570,843 - 2,573,822 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v21898,416,331 - 98,424,174 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan116104,328,442 - 104,336,271 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01669,356,396 - 69,364,225 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11689,016,349 - 89,024,719 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1689,016,349 - 89,024,719 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1564,692,865 - 64,701,056 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl564,692,123 - 64,704,893 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha564,703,545 - 64,711,735 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0564,912,202 - 64,920,393 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl564,911,577 - 64,920,464 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1564,938,335 - 64,946,503 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0564,770,091 - 64,778,279 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0565,176,122 - 65,184,313 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440934925,283,408 - 25,291,407 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366411,036,967 - 1,044,991 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366411,036,967 - 1,044,954 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl61,015,162 - 1,021,420 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.161,015,212 - 1,021,422 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1574,023,134 - 74,030,793 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl574,023,082 - 74,030,750 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660471,654,155 - 1,661,751 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_004624746911,842 - 919,362 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624746911,852 - 919,361 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Cyba
23 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:123
Count of miRNA genes:106
Interacting mature miRNAs:118
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194997648153225766Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)194434021455283277Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)193383821455283146Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21950,487,946 - 50,488,149 (+)MAPPERmRatBN7.2
Rnor_6.01955,249,983 - 55,250,185NCBIRnor6.0
Rnor_5.01965,960,167 - 65,960,369UniSTSRnor5.0
RGSC_v3.41952,713,499 - 52,713,701UniSTSRGSC3.4
Celera1949,727,491 - 49,727,693UniSTS
RH 3.4 Map19696.9UniSTS
Cytogenetic Map19q12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01965,967,927 - 65,968,109NCBIRnor5.0
Rnor_5.01149,620,644 - 149,620,826NCBIRnor5.0
RGSC_v3.41952,722,313 - 52,722,494UniSTSRGSC3.4
RGSC_v3.4X155,617,504 - 155,617,685UniSTSRGSC3.4
Celera1949,735,858 - 49,736,039UniSTS
Celera1133,317,703 - 133,317,884UniSTS
Cytogenetic Map19q12UniSTS
Cytogenetic MapXq37UniSTS

Genetic Models
This gene Cyba is modified in the following models/strains:
SS-Cybaem1Mcwi     MES/Slc    


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 41 52 40 19 40 2 4 42 35 35 11 2
Low 2 5 1 1 6 7 32 6 6
Below cutoff


RefSeq Acc Id: ENSRNOT00000017564   ⟹   ENSRNOP00000017564
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1950,487,597 - 50,495,721 (-)Ensembl
Rnor_6.0 Ensembl1955,249,616 - 55,257,876 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109691   ⟹   ENSRNOP00000083515
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1950,487,598 - 50,495,669 (-)Ensembl
RefSeq Acc Id: NM_024160   ⟹   NP_077074
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr81967,396,143 - 67,404,214 (-)NCBI
mRatBN7.21950,487,598 - 50,495,669 (-)NCBI
Rnor_6.01955,249,634 - 55,257,824 (-)NCBI
Rnor_5.01965,959,818 - 65,967,224 (-)NCBI
RGSC_v3.41952,713,150 - 52,721,609 (-)RGD
Celera1949,727,142 - 49,735,154 (-)RGD
Protein Sequences
Protein RefSeqs NP_077074 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA85865 (Get FASTA)   NCBI Sequence Viewer  
  AAK00811 (Get FASTA)   NCBI Sequence Viewer  
  CAC09434 (Get FASTA)   NCBI Sequence Viewer  
  EDL92746 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000017564
GenBank Protein Q62737 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_077074   ⟸   NM_024160
- UniProtKB: Q9ER27 (UniProtKB/Swiss-Prot),   Q62737 (UniProtKB/Swiss-Prot),   A6IZR8 (UniProtKB/TrEMBL),   A0A8L2Q8Y6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000017564   ⟸   ENSRNOT00000017564
RefSeq Acc Id: ENSRNOP00000083515   ⟸   ENSRNOT00000109691

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62737-F1-model_v2 AlphaFold Q62737 1-192 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13701205
Promoter ID:EPDNEW_R11728
Type:initiation region
Description:cytochrome b-245 alpha chain
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01955,257,830 - 55,257,890EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620573 AgrOrtholog
BioCyc Gene G2FUF-5398 BioCyc
Ensembl Genes ENSRNOG00000013014 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017564 ENTREZGENE
  ENSRNOT00000017564.7 UniProtKB/TrEMBL
  ENSRNOT00000109691.1 UniProtKB/TrEMBL
InterPro Cyt_b558_asu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:79129 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR15168 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cytochrom_B558a UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cyba PhenoGen
PIRSF Cytochr_b558a UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013014 RatGTEx
UniProt A0A8I5ZW01_RAT UniProtKB/TrEMBL
  CY24A_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q9ER27 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Cyba  cytochrome b-245, alpha polypeptide    cytochrome b558 alpha-subunit  Name updated 1299863 APPROVED
2002-08-07 Cyba  cytochrome b558 alpha-subunit      Symbol and Name status set to provisional 70820 PROVISIONAL