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Gene: Cyba (cytochrome b-245 alpha chain) Rattus norvegicus
Symbol: Cyba
Name: cytochrome b-245 alpha chain
Description: Contributes to superoxide-generating NADPH oxidase activity. Involved in several processes, including cellular response to gamma radiation; cellular response to organonitrogen compound; and positive regulation of cell population proliferation. Localizes to several cellular components, including the Golgi apparatus; NADPH oxidase complex; and focal adhesion. Colocalizes with the perinuclear endoplasmic reticulum. Used to study hypertension and pulmonary hypertension. Biomarker of diabetic retinopathy; end stage renal failure; hypertension; and myocardial infarction. Human ortholog(s) of this gene implicated in artery disease (multiple); asthma; chronic obstructive pulmonary disease; and phagocyte bactericidal dysfunction (multiple). Orthologous to human CYBA (cytochrome b-245 alpha chain); PARTICIPATES IN thyroid hormone biosynthetic pathway; Leishmaniasis pathway; phagocytosis pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate; 11-deoxycorticosterone.
Type: protein-coding
Also known as: alpha-subunit p22; cytochrome b(558) alpha chain; cytochrome b-245 light chain; cytochrome b-245, alpha polypeptide; cytochrome b558 alpha-subunit; cytochrome b558 subunit alpha; neutrophil cytochrome b 22 kDa polypeptide; p22 phagocyte B-cytochrome; p22-phox; p22phox; Phox; superoxide-generating NADPH oxidase light chain subunit
Homo sapiens (human) : CYBA (cytochrome b-245 alpha chain)  HGNC  Alliance
Mus musculus (house mouse) : Cyba (cytochrome b-245, alpha polypeptide)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : LOC102004641 (cytochrome b-245 light chain)
Pan paniscus (bonobo/pygmy chimpanzee) : LOC100986914 (cytochrome b-245 light chain)
Canis lupus familiaris (dog) : CYBA (cytochrome b-245 alpha chain)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101967032 (cytochrome b-245 light chain)
Sus scrofa (pig) : CYBA (cytochrome b-245, alpha polypeptide)
more info ...
Allele / Splice: Cybaem1Mcwi   Cybam1Sdi  
Genetic Models: MES/Slc SS-Cybaem1Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01955,249,634 - 55,257,824 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01965,959,818 - 65,967,224 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41952,713,150 - 52,721,609 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11952,718,030 - 52,726,490 (-)NCBI
Celera1949,727,142 - 49,735,154 (-)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
More on Cyba
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620573
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.