Cck (cholecystokinin) - Rat Genome Database

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Gene: Cck (cholecystokinin) Rattus norvegicus
Analyze
Symbol: Cck
Name: cholecystokinin
RGD ID: 2288
Description: Enables neuropeptide hormone activity. Involved in several processes, including learning or memory; positive regulation of protein metabolic process; and regulation of behavioral fear response. Located in several cellular components, including axon; dendrite; and perikaryon. Is active in GABA-ergic synapse. Used to study cataract. Orthologous to human CCK (cholecystokinin); INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,3,4,7,8-Pentachlorodibenzofuran; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28121,153,499 - 121,160,194 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8121,153,500 - 121,160,084 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8126,751,677 - 126,758,281 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.08124,950,740 - 124,957,344 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.08122,780,342 - 122,786,944 (-)NCBIRnor_WKY
Rnor_6.08130,120,525 - 130,127,515 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8130,120,523 - 130,127,392 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08129,312,785 - 129,319,582 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48126,492,636 - 126,499,220 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18126,512,372 - 126,518,954 (-)NCBI
Celera8120,288,523 - 120,295,093 (-)NCBICelera
RH 3.4 Map81282.1RGD
RH 3.4 Map81254.7RGD
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
15-acetyldeoxynivalenol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-acetamidofluorene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-acetyldeoxynivalenol  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
5-aza-2'-deoxycytidine  (ISO)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
apomorphine  (EXP)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bromosulfophthalein  (ISO)
butanal  (ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
capsaicin  (EXP,ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP,ISO)
clozapine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cylindrospermopsin  (ISO)
deoxynivalenol  (ISO)
devazepide  (ISO)
dibutyl phthalate  (EXP)
dinophysistoxin 1  (ISO)
disulfiram  (EXP,ISO)
dizocilpine maleate  (EXP)
dorsomorphin  (ISO)
ethanol  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
fenamidone  (ISO)
fluoxetine  (EXP,ISO)
folic acid  (ISO)
Fusarenone X  (ISO)
genistein  (ISO)
haloperidol  (EXP)
hydrogen peroxide  (ISO)
irinotecan  (EXP)
kainic acid  (EXP)
L-365260  (ISO)
malathion  (EXP)
melatonin  (EXP)
methamphetamine  (EXP,ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
morphine  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-Nitrosopyrrolidine  (ISO)
naloxone  (EXP)
nicotine  (ISO)
nitrendipine  (ISO)
nitrobenzenes  (EXP)
Nivalenol  (ISO)
octreotide  (ISO)
orlistat  (ISO)
paracetamol  (ISO)
parathion  (EXP)
parathion-methyl  (EXP)
PCB138  (ISO)
pentanal  (ISO)
progesterone  (ISO)
propanal  (ISO)
resveratrol  (EXP)
rotenone  (ISO)
ruthenium red  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium fluoride  (EXP)
Sodium oleate  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenylphosphane oxide  (ISO)
U-73122  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Inhibition of pro-cholecystokinin (CCK) sulfation by treatment with sodium chlorate alters its processing and decreases cellular content and secretion of CCK 8. Beinfeld MC Neuropeptides. 1994 Mar;26(3):195-200.
2. Distribution and colocalization of cholecystokinin with the prohormone convertase enzymes PC1, PC2, and PC5 in rat brain. Cain BM, etal., J Comp Neurol 2003 Dec 15;467(3):307-25.
3. Effect of intraperitoneal mRNA antisense-oligodeoxynucleotides to cholecystokinin on anxiety-like and learning behaviors in rats: association with pre-experimental stress. Cohen H, etal., Neuropeptides. 2002 Oct;36(5):341-52.
4. Peripheral interaction of ghrelin with cholecystokinin on feeding regulation. Date Y, etal., Endocrinology. 2005 Aug;146(8):3518-25. Epub 2005 May 12.
5. Cholecystokinin facilitates glutamate release by increasing the number of readily releasable vesicles and releasing probability. Deng PY, etal., J Neurosci. 2010 Apr 14;30(15):5136-48. doi: 10.1523/JNEUROSCI.5711-09.2010.
6. Modulation of cholecystokinin gene expression. Deschenes RJ, etal., Ann N Y Acad Sci 1985;448:53-60.
7. A gene encoding rat cholecystokinin. Isolation, nucleotide sequence, and promoter activity. Deschenes RJ, etal., J Biol Chem 1985 Jan 25;260(2):1280-6.
8. Cloning and sequence analysis of a cDNA encoding rat preprocholecystokinin. Deschenes RJ, etal., Proc Natl Acad Sci U S A 1984 Feb;81(3):726-30.
9. Postprandial cholecystokinin release and gastric emptying in patients with bulimia nervosa. Devlin MJ, etal., Am J Clin Nutr. 1997 Jan;65(1):114-20.
10. Association between polymorphism of the cholecystokinin gene and idiopathic Parkinson's disease. Fujii C, etal., Clin Genet. 1999 Nov;56(5):394-9.
11. An association of NAG levels and a mutation of the CCK gene in panic disorder patients. Garvey MJ, etal., Psychiatry Res 1998 Aug 17;80(2):149-53.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Alteration of CCK-induced satiety in post-Nippostrongylus brasiliensis-infected rats. Gay J, etal., Brain Behav Immun. 2003 Feb;17(1):35-42.
14. Cholecystokinin modulates migration of gonadotropin-releasing hormone-1 neurons. Giacobini P, etal., J Neurosci. 2004 May 19;24(20):4737-48.
15. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
16. Cholecystokinin induces caspase activation and mitochondrial dysfunction in pancreatic acinar cells. Roles in cell injury processes of pancreatitis.PG - 22595-604 Gukovskaya AS, etal., J Biol Chem 2002 Jun 21;277(25):22595-604.
17. Cholecystokinin induces caspase activation and mitochondrial dysfunction in pancreatic acinar cells. Roles in cell injury processes of pancreatitis. Gukovskaya AS, etal., J Biol Chem 2002 Jun 21;277(25):22595-604. Epub 2002 Apr 18.
18. The antagonism of cholecystokinin octapeptide-8 to the peroxynitrite oxidation on a diabetic cataractal rat model. Hao LN, etal., Chin Med J (Engl). 2006 Sep 5;119(17):1451-7.
19. Role of cholecystokinin-A and cholecystokinin-B receptors in anxiety. Hernandez-Gomez AM, etal., Amino Acids 2002;23(1-3):283-90.
20. A role for dopamine in feeding responses produced by orexigenic agents. Hnasko TS, etal., Brain Res. 2004 Oct 15;1023(2):309-18.
21. Identification of overlapping AP-2/NF-kappa B-responsive elements on the rat cholecystokinin gene promoter. Katsel PL and Greenstein RJ, J Biol Chem 2001 Jan 5;276(1):752-8.
22. Cholecystokinin octapeptide: a potential growth factor for pancreatic beta cells in diabetic rats. Kuntz E, etal., JOP. 2004 Nov 10;5(6):464-75.
23. Molecular cloning and nucleotide sequence of cDNA coding for rat brain cholecystokinin precursor. Kuwano R, etal., J Biochem (Tokyo) 1984 Sep;96(3):923-6.
24. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
25. Immunohistochemical characterization of cholecystokinin containing neurons in the rat basolateral amygdala. Mascagni F and McDonald AJ, Brain Res. 2003 Jun 27;976(2):171-84.
26. Hyperphagia during lactation: satiety response to CCK and growth of the pancreas. McLaughlin CL, etal., Am J Physiol. 1983 Jan;244(1):E61-5.
27. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
28. Postnatal development and migration of cholecystokinin-immunoreactive interneurons in rat hippocampus. Morozov YM and Freund TF, Neuroscience. 2003;120(4):923-39.
29. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
30. Role of the amygdaloid cholecystokinin (CCK)/gastrin-2 receptors and terminal networks in the modulation of anxiety in the rat. Effects of CCK-4 and CCK-8S on anxiety-like behaviour and GABA release. Perez de la Mora M, etal., Eur J Neurosci. 2007 Dec;26(12):3614-30.
31. Cholecystokinin stimulates extracellular signal-regulated kinase through activation of the epidermal growth factor receptor, Yes, and protein kinase C. Signal amplification at the level of Raf by activation of protein kinase Cepsilon. Piiper A, etal., J Biol Chem. 2003 Feb 28;278(9):7065-72. Epub 2002 Dec 20.
32. Effects of peripheral CCK receptor blockade on gastric emptying in rats. Reidelberger RD, etal., Am J Physiol Regul Integr Comp Physiol 2003 Jan;284(1):R66-75.
33. GOA pipeline RGD automated data pipeline
34. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
35. Peripheral participation of cholecystokinin in the morphine-induced peripheral antinociceptive effect in non-diabetic and diabetic rats. Torres-Lopez JE, etal., Neuropharmacology. 2007 Mar;52(3):788-95. Epub 2006 Dec 6.
36. Cholecystokinin, cholecystokinin-A receptor and cholecystokinin-B receptor gene polymorphisms in Parkinson's disease. Wang J, etal., Pharmacogenetics. 2003 Jun;13(6):365-9.
37. Cholecystokinin in the rostral ventromedial medulla mediates opioid-induced hyperalgesia and antinociceptive tolerance. Xie JY, etal., J Neurosci. 2005 Jan 12;25(2):409-16.
38. Basal and postprandial plasma levels of PPY, ghrelin, cholecystokinin, gastrin and insulin in women with moderate and morbid obesity and metabolic syndrome. Zwirska-Korczala K, etal., J Physiol Pharmacol. 2007 Mar;58 Suppl 1:13-35.
Additional References at PubMed
PMID:7681836   PMID:12479974   PMID:12829630   PMID:12914981   PMID:12946704   PMID:14559369   PMID:14698681   PMID:15040036   PMID:15260493   PMID:15464747   PMID:15561439   PMID:16143427  
PMID:16274843   PMID:16535834   PMID:16837074   PMID:17505309   PMID:17904218   PMID:18297100   PMID:18587446   PMID:18776046   PMID:19253017   PMID:19656488   PMID:19726710   PMID:19896983  
PMID:21093507   PMID:21239630   PMID:21270124   PMID:21525858   PMID:22813405   PMID:23027805   PMID:23785073   PMID:24121132   PMID:24309294   PMID:24487953   PMID:24564397   PMID:24732637  
PMID:25117406   PMID:25627687   PMID:25846408   PMID:26167074   PMID:27534875   PMID:27535680   PMID:28466358   PMID:28684275   PMID:29339381   PMID:31012948   PMID:33422646  


Genomics

Comparative Map Data
Cck
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28121,153,499 - 121,160,194 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8121,153,500 - 121,160,084 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8126,751,677 - 126,758,281 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.08124,950,740 - 124,957,344 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.08122,780,342 - 122,786,944 (-)NCBIRnor_WKY
Rnor_6.08130,120,525 - 130,127,515 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8130,120,523 - 130,127,392 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08129,312,785 - 129,319,582 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48126,492,636 - 126,499,220 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18126,512,372 - 126,518,954 (-)NCBI
Celera8120,288,523 - 120,295,093 (-)NCBICelera
RH 3.4 Map81282.1RGD
RH 3.4 Map81254.7RGD
Cytogenetic Map8q32NCBI
CCK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38342,257,826 - 42,266,185 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl342,257,825 - 42,266,185 (-)EnsemblGRCh38hg38GRCh38
GRCh37342,299,318 - 42,307,677 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36342,274,322 - 42,281,399 (-)NCBINCBI36Build 36hg18NCBI36
Build 34342,274,321 - 42,281,399NCBI
Celera342,238,692 - 42,247,029 (-)NCBICelera
Cytogenetic Map3p22.1NCBI
HuRef342,342,652 - 42,351,001 (-)NCBIHuRef
CHM1_1342,250,425 - 42,258,774 (-)NCBICHM1_1
T2T-CHM13v2.0342,275,821 - 42,284,183 (-)NCBIT2T-CHM13v2.0
Cck
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399121,318,890 - 121,324,760 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9121,318,890 - 121,324,760 (-)EnsemblGRCm39 Ensembl
GRCm389121,489,824 - 121,495,694 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9121,489,824 - 121,495,694 (-)EnsemblGRCm38mm10GRCm38
MGSCv379121,398,942 - 121,404,807 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369121,338,523 - 121,344,360 (-)NCBIMGSCv36mm8
Celera9121,960,523 - 121,966,357 (-)NCBICelera
Cytogenetic Map9F4NCBI
cM Map972.43NCBI
Cck
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542028,438,806 - 28,443,458 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542028,438,806 - 28,443,458 (+)NCBIChiLan1.0ChiLan1.0
CCK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1342,431,021 - 42,439,396 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl342,431,022 - 42,439,396 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0342,168,012 - 42,176,358 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CCK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12311,414,254 - 11,419,990 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2311,414,249 - 11,454,198 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2311,451,726 - 11,457,488 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02311,701,990 - 11,707,749 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2311,701,991 - 11,707,673 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12311,504,111 - 11,509,872 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02311,646,349 - 11,652,103 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02311,650,493 - 11,656,260 (-)NCBIUU_Cfam_GSD_1.0
Cck
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118200,424,409 - 200,429,945 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366952,776,831 - 2,782,061 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049366952,776,705 - 2,782,280 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1325,937,645 - 25,945,793 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11325,940,674 - 25,945,879 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21328,610,211 - 28,615,371 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CCK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1223,698,192 - 3,705,443 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl223,698,173 - 3,704,956 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041163,500,609 - 163,507,518 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cck
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473077,309,633 - 77,314,384 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473077,310,080 - 77,314,258 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cck
53 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:149
Count of miRNA genes:118
Interacting mature miRNAs:130
Transcripts:ENSRNOT00000026159
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat

Markers in Region
RH94772  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28121,153,421 - 121,153,626 (+)MAPPERmRatBN7.2
Rnor_6.08130,120,447 - 130,120,651NCBIRnor6.0
Rnor_5.08129,312,708 - 129,312,912UniSTSRnor5.0
RGSC_v3.48126,492,558 - 126,492,762UniSTSRGSC3.4
Celera8120,288,445 - 120,288,649UniSTS
RH 3.4 Map81254.7UniSTS
Cytogenetic Map8q32UniSTS
RH94468  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28121,158,952 - 121,159,039 (+)MAPPERmRatBN7.2
Rnor_6.08130,125,978 - 130,126,064NCBIRnor6.0
Rnor_5.08129,318,239 - 129,318,325UniSTSRnor5.0
RGSC_v3.48126,498,089 - 126,498,175UniSTSRGSC3.4
Celera8120,293,977 - 120,294,063UniSTS
Cytogenetic Map8q32UniSTS
Cck  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28121,153,784 - 121,153,877 (+)MAPPERmRatBN7.2
Rnor_6.08130,120,810 - 130,120,902NCBIRnor6.0
Rnor_5.08129,313,071 - 129,313,163UniSTSRnor5.0
RGSC_v3.48126,492,921 - 126,493,013UniSTSRGSC3.4
Celera8120,288,808 - 120,288,900UniSTS
Cytogenetic Map8q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 45
Low 3 7 5 4 4 29 20 24 2
Below cutoff 29 25 18 16 18 6 9 13 16 6 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000026159   ⟹   ENSRNOP00000026159
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8121,153,500 - 121,160,084 (-)Ensembl
Rnor_6.0 Ensembl8130,120,523 - 130,127,392 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000102218   ⟹   ENSRNOP00000097411
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8121,153,850 - 121,158,926 (-)Ensembl
RefSeq Acc Id: NM_012829   ⟹   NP_036961
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28121,153,500 - 121,160,084 (-)NCBI
Rnor_6.08130,120,525 - 130,127,109 (-)NCBI
Rnor_5.08129,312,785 - 129,319,582 (-)NCBI
RGSC_v3.48126,492,636 - 126,499,220 (-)RGD
Celera8120,288,523 - 120,295,093 (-)RGD
Sequence:
RefSeq Acc Id: XM_039080873   ⟹   XP_038936801
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28121,153,499 - 121,160,194 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_036961   ⟸   NM_012829
- Peptide Label: preproprotein
- UniProtKB: P01355 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000026159   ⟸   ENSRNOT00000026159
RefSeq Acc Id: XP_038936801   ⟸   XM_039080873
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000097411   ⟸   ENSRNOT00000102218
Protein Domains
Gastrin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P01355-F1-model_v2 AlphaFold P01355 1-115 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696388
Promoter ID:EPDNEW_R6912
Type:multiple initiation site
Name:Cck_1
Description:cholecystokinin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08130,127,059 - 130,127,119EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2288 AgrOrtholog
BioCyc Gene G2FUF-28692 BioCyc
Ensembl Genes ENSRNOG00000019321 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000026159 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000097411.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026159 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000102218.1 UniProtKB/TrEMBL
InterPro CCK-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gastrin/CCK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gastrin/cholecystokinin_CS UniProtKB/Swiss-Prot
KEGG Report rno:25298 UniProtKB/Swiss-Prot
NCBI Gene 25298 ENTREZGENE
PANTHER PTHR10786 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Gastrin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cck PhenoGen
PROSITE GASTRIN UniProtKB/Swiss-Prot
UniProt A0A8I6ASM0_RAT UniProtKB/TrEMBL
  CCKN_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Cck  cholecystokinin      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the brain and the endocrine cells of the gastrointestinal tract 628552
gene_function acts as a neurotransmitter or neuromodulator in the brain  
gene_process a neurotransmitter in the brain 67923
gene_process a neurotransmitter in the brain 625521
gene_process has hemacrine and autocrine action in the gut 67923
gene_process has hemacrine and autocrine action in the gut 625521
gene_process stimulates the intestinal vagal sensory neurons to inhibit gastric emptying 628552
gene_process acts as a neurotransmitter or neuromodulator in the brain 628552
gene_process stimulates apoptosis and death signaling pathways in rat pancreatic acinar cells 1298735
gene_regulation transcriptional control by phorbol ester, cAMP, and gonadal steroids, as well as glucocorticoids 67923
gene_regulation transcriptional control by phorbol ester, cAMP, and gonadal steroids, as well as glucocorticoids 625521
gene_transcript over-lapped AP-2- and NF-kB-responsive elements within the 17-base pair sequence between 2149 and 2134 of the distal 5 flanking region||several cis-elements, important in transcriptional control, identified within the first 119 bp of the 59 flanking regio 67923
gene_transcript severalcis-elements,importantintranscriptionalcontrol,identifiedwithinthefirst119bpofthe59flankingregion 67923