Cs (citrate synthase) - Rat Genome Database

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Gene: Cs (citrate synthase) Rattus norvegicus
Analyze
Symbol: Cs
Name: citrate synthase
RGD ID: 620330
Description: Enables citrate (Si)-synthase activity. Involved in several processes, including acetyl-CoA metabolic process; carboxylic acid metabolic process; and tricarboxylic acid cycle. Located in mitochondrion. Used to study congestive heart failure; hyperthyroidism; hypothyroidism; limb ischemia; and myocardial infarction. Biomarker of bipolar disorder and congestive heart failure. Human ortholog(s) of this gene implicated in dilated cardiomyopathy and hypertrophic cardiomyopathy. Orthologous to human CS (citrate synthase); PARTICIPATES IN citric acid cycle pathway; fumaric aciduria pathway; mitochondrial complex II deficiency pathway; INTERACTS WITH (S)-amphetamine; 17alpha-ethynylestradiol; 2,2,2-tetramine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: citrate (Si)-synthase; citrate synthase precursor; citrate synthase, mitochondrial
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr871,348,389 - 1,374,624 (+)NCBIGRCr8
mRatBN7.27758,074 - 791,421 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7758,345 - 791,421 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx73,522,514 - 3,550,877 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.075,398,497 - 5,426,861 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.075,698,983 - 5,725,551 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.072,752,680 - 2,778,963 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl72,752,680 - 2,778,963 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.072,731,092 - 2,757,427 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.471,626,181 - 1,652,197 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.171,626,180 - 1,652,197 (+)NCBI
Celera7639,242 - 663,715 (+)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-anisomycin  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-amphetamine  (EXP)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2-(1-naphthalenylmethyl)-3-(2-oxolanyl)propanoic acid 2-(diethylamino)ethyl ester  (EXP)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,4-dihydroxybenzoic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-DAMP(1+)  (EXP)
5-aminolevulinic acid  (EXP)
5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid  (ISO)
7,12-dimethyltetraphene  (ISO)
acrolein  (EXP,ISO)
actinomycin D  (EXP,ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
aldosterone  (EXP)
all-trans-retinoic acid  (ISO)
alprenolol  (EXP)
AM-251  (ISO)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atorvastatin calcium  (EXP)
benzo[a]pyrene  (ISO)
benzylpenicillin  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
bupivacaine  (EXP)
butan-1-ol  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
captan  (ISO)
carbon nanotube  (ISO)
celastrol  (ISO)
chicoric acid  (EXP)
chlorogenic acid  (ISO)
chloroquine  (ISO)
cholesterol  (ISO)
cisplatin  (EXP,ISO)
clobetasol  (ISO)
clofibrate  (EXP)
clofibric acid  (EXP)
cobalt dichloride  (EXP,ISO)
corticosterone  (EXP)
cortisol  (EXP)
curcumin  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
Deoxycorticosterone acetate  (EXP)
desipramine  (ISO)
dexamethasone  (EXP,ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
diisononyl phthalate  (ISO)
dimethyl sulfoxide  (ISO)
Diosbulbin B  (ISO)
dioxygen  (EXP,ISO)
diphenyl diselenide  (EXP)
dopamine  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
ebselen  (EXP,ISO)
enalapril  (EXP)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
erythromycin A  (ISO)
Erythropoietin  (ISO)
ethanol  (ISO)
finasteride  (EXP)
fluoxetine  (EXP)
flutamide  (EXP)
folpet  (ISO)
FR900359  (ISO)
furfural  (ISO)
gallic acid  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glyphosate  (ISO)
hydrogen peroxide  (EXP)
indometacin  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
josamycin  (ISO)
kaempferol  (ISO)
L-ascorbic acid  (ISO)
L-serine  (EXP)
lead(0)  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
methamphetamine  (EXP)
methylmercury chloride  (ISO)
miconazole  (ISO)
mifepristone  (EXP)
MitoTEMPO  (ISO)
mitoxantrone  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-hexadecanoylsphingosine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nicotine  (ISO)
nitrites  (EXP)
Nutlin-3  (ISO)
O-acetyl-L-carnitine  (EXP)
ochratoxin A  (ISO)
olanzapine  (EXP)
ouabain  (EXP)
ozone  (EXP,ISO)
paroxetine  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl caffeate  (ISO)
phenobarbital  (ISO)
phlorizin  (ISO)
pirinixic acid  (ISO)
quercetin  (EXP)
resveratrol  (EXP,ISO)
simvastatin  (EXP)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium chloride  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
spironolactone  (EXP)
sucrose  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tauroursodeoxycholic acid  (ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
titanium dioxide  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
trovafloxacin  (EXP)
tyrosine  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
zidovudine  (ISO)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
mitochondrial matrix  (IBA,IEA,ISO,ISS)
mitochondrion  (IDA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Inactivation of aconitase and oxoglutarate dehydrogenase in skeletal muscle in vitro by superoxide anions and/or nitric oxide. Andersson U, etal., Biochem Biophys Res Commun. 1998 Aug 19;249(2):512-6.
2. Skeletal muscle metabolism in heart failure in rats. Arnolda L, etal., Am J Physiol. 1991 Aug;261(2 Pt 2):H434-42. doi: 10.1152/ajpheart.1991.261.2.H434.
3. Effects of ischaemia on enzyme-activities in the soleus muscle of the rat. Bass A, etal., Pflugers Arch. 1979 Mar 16;379(2):203-8. doi: 10.1007/BF00586949.
4. Rat skeletal muscle metabolism in experimental heart failure: effects of physical training. Brunotte F, etal., Acta Physiol Scand. 1995 Aug;154(4):439-47. doi: 10.1111/j.1748-1716.1995.tb09929.x.
5. Brain energy metabolism parameters in an animal model of diabetes. Ceretta LB, etal., Metab Brain Dis. 2010 Dec;25(4):391-6. doi: 10.1007/s11011-010-9220-z. Epub 2010 Nov 19.
6. Nardilysin facilitates complex formation between mitochondrial malate dehydrogenase and citrate synthase. Chow KM, etal., Biochim Biophys Acta. 2005 May 25;1723(1-3):292-301. Epub 2005 Mar 10.
7. Neuroprotective effects of spermine following hypoxic-ischemic-induced brain damage: a mechanistic study. Clarkson AN, etal., FASEB J. 2004 Jul;18(10):1114-6. doi: 10.1096/fj.03-1203fje. Epub 2004 May 7.
8. Effects of lithium and valproate on hippocampus citrate synthase activity in an animal model of mania. Corrêa C, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2007 May 9;31(4):887-91. doi: 10.1016/j.pnpbp.2007.02.005. Epub 2007 Feb 15.
9. Developmental changes of cytochrome c oxidase and citrate synthase in rat heart homogenate. Drahota Z, etal., Physiol Res. 2004;53(1):119-22.
10. Skeletal muscle mitochondrial dysfunction precedes right ventricular impairment in experimental pulmonary hypertension. Enache I, etal., Mol Cell Biochem. 2013 Jan;373(1-2):161-70. doi: 10.1007/s11010-012-1485-6. Epub 2012 Oct 26.
11. Evaluation of citrate synthase activity in brain of rats submitted to an animal model of mania induced by ouabain. Freitas TP, etal., Mol Cell Biochem. 2010 Aug;341(1-2):245-9. doi: 10.1007/s11010-010-0455-0. Epub 2010 Apr 7.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Cloning and molecular analysis of the human citrate synthase gene. Goldenthal MJ, etal., Genome 1998 Oct;41(5):733-8.
14. Nox4 Knockout Does Not Prevent Diaphragm Atrophy, Contractile Dysfunction, or Mitochondrial Maladaptation in the Early Phase Post-Myocardial Infarction in Mice. Hahn D, etal., Cell Physiol Biochem. 2021 Aug 20;55(4):489-504. doi: 10.33594/000000400.
15. Alterations in the expression of myosin heavy chain isoforms in hypoxia-induced hypertrophied ventricles in rats. Hashimoto T, etal., Comp Biochem Physiol B Biochem Mol Biol. 2003 Sep;136(1):139-45. doi: 10.1016/s1096-4959(03)00182-9.
16. Respiratory Muscle Training Improves Diaphragm Citrate Synthase Activity and Hemodynamic Function in Rats with Heart Failure. Jaenisch RB, etal., Braz J Cardiovasc Surg. 2017 Mar-Apr;32(2):104-110. doi: 10.21470/1678-9741-2017-0002.
17. Energetics and function of the failing human heart with dilated or hypertrophic cardiomyopathy. Kalsi KK, etal., Eur J Clin Invest. 1999 Jun;29(6):469-77. doi: 10.1046/j.1365-2362.1999.00468.x.
18. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
19. Preparation and properties of mitochondria derived from synaptosomes. Lai JC and Clark JB, Biochem J. 1976 Feb 15;154(2):423-32.
20. Lipidomic analysis of molecular cardiolipin species in livers exposed to ischemia/reperfusion. Martens JC, etal., Mol Cell Biochem. 2015 Feb;400(1-2):253-63. doi: 10.1007/s11010-014-2282-1. Epub 2014 Nov 23.
21. Euterpe oleracea Mart. (Açai) Supplementation Attenuates Acute Doxorubicin-Induced Cardiotoxicity in Rats. Mathias LMBS, etal., Cell Physiol Biochem. 2019;53(2):388-399. doi: 10.33594/000000145.
22. Thyroid status and nitric oxide in rat arterial vessels. McAllister RM, etal., J Endocrinol. 2005 Apr;185(1):111-9. doi: 10.1677/joe.1.06022.
23. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
24. Underlying mechanism of the contractile dysfunction in atrophied ventricular myocytes from a murine model of hypothyroidism. Montalvo D, etal., Cell Calcium. 2018 Jun;72:26-38. doi: 10.1016/j.ceca.2018.01.005. Epub 2018 Feb 5.
25. Studies of the mechanism by which hepatic citrate synthase activity increases in vitamin B12 deprivation. Mukherjee A, etal., J Biol Chem. 1976 Apr 10;251(7):2155-60.
26. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
27. Effects of prior treatment with simvastatin on skeletal muscle structure and mitochondrial enzyme activities during early phases of sepsis. Ozkok E, etal., Int J Clin Exp Pathol. 2014 Dec 1;7(12):8356-65. eCollection 2014.
28. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
29. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
30. Effects of streptozotocin-induced diabetes on markers of skeletal muscle metabolism and monocarboxylate transporter 1 to monocarboxylate transporter 4 transporters. Py G, etal., Metabolism. 2002 Jul;51(7):807-13. doi: 10.1053/meta.2002.33343.
31. GOA pipeline RGD automated data pipeline
32. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
33. Inhibition of brain citrate synthase activity in an animal model of sepsis. Scaini G, etal., Rev Bras Ter Intensiva. 2011 Jun;23(2):158-63.
34. The kinetic properties of citrate synthase from rat liver mitochondria. Shepherd D and Garland PB, Biochem J. 1969 Sep;114(3):597-610.
35. Neuroprotective effects of (-)-epigallocatechin gallate following hypoxia-ischemia-induced brain damage: novel mechanisms of action. Sutherland BA, etal., FASEB J. 2005 Feb;19(2):258-60. doi: 10.1096/fj.04-2806fje. Epub 2004 Nov 29.
36. Ventricular adenine nucleotide translocator mRNA is upregulated in dilated cardiomyopathy. Sylvén C, etal., Cardiovasc Res. 1993 Jul;27(7):1295-9. doi: 10.1093/cvr/27.7.1295.
37. Time series proteome profile analysis reveals a protective role of citrate synthase in angiotensin II-induced atrial fibrillation. Teng F, etal., J Hypertens. 2022 Apr 1;40(4):765-775. doi: 10.1097/HJH.0000000000003075.
38. Potential importance of glomerular citrate synthase activity in remnant nephropathy. Ullian ME, etal., Kidney Int 2003 Jan;63(1):156-64.
39. Effects of tamoxifen on tricarboxylic acid cycle enzymes in the brain of rats submitted to an animal model of mania induced by amphetamine. Valvassori SS, etal., Psychiatry Res. 2014 Feb 28;215(2):483-7. doi: 10.1016/j.psychres.2013.11.016. Epub 2013 Nov 21.
40. Detection of citrate synthase autoantibodies in rats with chronic allograft nephropathy. Zhang LY, etal., Transplant Proc. 2009 Dec;41(10):4366-8. doi: 10.1016/j.transproceed.2009.08.071.
Additional References at PubMed
PMID:9543345   PMID:10543959   PMID:14651853   PMID:16751257   PMID:18614015   PMID:18729827   PMID:19308875   PMID:20458337   PMID:20833797   PMID:21630459   PMID:22681889   PMID:23376485  
PMID:23602810   PMID:25378300   PMID:26316108   PMID:29476059   PMID:29867124   PMID:34350838  


Genomics

Comparative Map Data
Cs
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr871,348,389 - 1,374,624 (+)NCBIGRCr8
mRatBN7.27758,074 - 791,421 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7758,345 - 791,421 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx73,522,514 - 3,550,877 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.075,398,497 - 5,426,861 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.075,698,983 - 5,725,551 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.072,752,680 - 2,778,963 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl72,752,680 - 2,778,963 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.072,731,092 - 2,757,427 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.471,626,181 - 1,652,197 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.171,626,180 - 1,652,197 (+)NCBI
Celera7639,242 - 663,715 (+)NCBICelera
Cytogenetic Map7q11NCBI
CS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381256,271,699 - 56,300,330 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1256,271,699 - 56,300,391 (-)EnsemblGRCh38hg38GRCh38
GRCh371256,665,483 - 56,694,114 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361254,951,750 - 54,980,442 (-)NCBINCBI36Build 36hg18NCBI36
Celera1256,318,264 - 56,346,961 (-)NCBICelera
Cytogenetic Map12q13.3NCBI
HuRef1253,704,180 - 53,732,652 (-)NCBIHuRef
CHM1_11256,632,888 - 56,661,575 (-)NCBICHM1_1
T2T-CHM13v2.01256,239,343 - 56,267,970 (-)NCBIT2T-CHM13v2.0
Cs
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910128,173,596 - 128,198,351 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10128,173,603 - 128,198,348 (+)EnsemblGRCm39 Ensembl
GRCm3810128,337,727 - 128,362,482 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,337,734 - 128,362,479 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710127,774,888 - 127,799,535 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610127,740,781 - 127,765,428 (+)NCBIMGSCv36mm8
Celera10130,726,084 - 130,750,750 (+)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1076.53NCBI
Cs
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554583,881,798 - 3,893,401 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554583,881,798 - 3,913,044 (-)NCBIChiLan1.0ChiLan1.0
CS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21038,028,323 - 38,060,438 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11238,028,468 - 38,057,206 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01232,614,982 - 32,643,719 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11232,867,225 - 32,895,854 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1232,867,225 - 32,895,854 (+)Ensemblpanpan1.1panPan2
CS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.110584,000 - 611,351 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl10584,904 - 611,436 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha10647,257 - 674,790 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.010592,484 - 620,012 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl10592,484 - 620,005 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.110569,926 - 597,448 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.010812,910 - 840,419 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.010937,007 - 964,321 (-)NCBIUU_Cfam_GSD_1.0
Cs
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494558,165,176 - 58,193,309 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936646678,307 - 692,777 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936646676,926 - 704,988 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl521,666,585 - 21,700,711 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1521,669,778 - 21,700,737 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2523,162,491 - 23,186,518 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap5p12-p13NCBI
CS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11152,224,667 - 52,253,552 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1152,222,724 - 52,253,307 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037193,729,868 - 193,761,327 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Cs
205 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:85
Count of miRNA genes:75
Interacting mature miRNAs:79
Transcripts:ENSRNOT00000033726
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat

Markers in Region
RH128613  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27788,946 - 789,952 (+)MAPPERmRatBN7.2
mRatBN7.2734,600,337 - 34,600,519 (+)MAPPERmRatBN7.2
Rnor_6.0741,978,645 - 41,978,826NCBIRnor6.0
Rnor_6.072,777,788 - 2,778,793NCBIRnor6.0
Rnor_5.0742,011,933 - 42,012,114UniSTSRnor5.0
Rnor_5.072,756,252 - 2,757,257UniSTSRnor5.0
RGSC_v3.4737,414,998 - 37,415,179UniSTSRGSC3.4
RGSC_v3.471,651,022 - 1,652,027UniSTSRGSC3.4
Celera731,611,119 - 31,611,300UniSTS
Celera7662,540 - 663,545UniSTS
Cytogenetic Map7q13UniSTS
Cytogenetic Map7q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000033726   ⟹   ENSRNOP00000034921
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7763,824 - 791,419 (+)Ensembl
Rnor_6.0 Ensembl72,752,680 - 2,778,963 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115725   ⟹   ENSRNOP00000096005
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7763,766 - 791,421 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116919   ⟹   ENSRNOP00000087073
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7758,345 - 791,421 (+)Ensembl
RefSeq Acc Id: NM_130755   ⟹   NP_570111
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,348,389 - 1,374,624 (+)NCBI
mRatBN7.27763,883 - 790,122 (+)NCBI
Rnor_6.072,752,680 - 2,778,963 (+)NCBI
Rnor_5.072,731,092 - 2,757,427 (+)NCBI
RGSC_v3.471,626,181 - 1,652,197 (+)RGD
Celera7639,242 - 663,715 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_570111 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAL66372 (Get FASTA)   NCBI Sequence Viewer  
  ABD77259 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000034921
GenBank Protein Q8VHF5 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_570111   ⟸   NM_130755
- Peptide Label: precursor
- UniProtKB: Q8VHF5 (UniProtKB/Swiss-Prot),   G3V936 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000034921   ⟸   ENSRNOT00000033726
Ensembl Acc Id: ENSRNOP00000096005   ⟸   ENSRNOT00000115725
Ensembl Acc Id: ENSRNOP00000087073   ⟸   ENSRNOT00000116919

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VHF5-F1-model_v2 AlphaFold Q8VHF5 1-466 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694933
Promoter ID:EPDNEW_R5458
Type:initiation region
Name:Cs_1
Description:citrate synthase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.072,752,636 - 2,752,696EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620330 AgrOrtholog
BioCyc Gene G2FUF-35376 BioCyc
BioCyc Pathway PWY-5690 [TCA cycle II (plants and fungi)] BioCyc
BioCyc Pathway Image PWY-5690 BioCyc
Ensembl Genes ENSRNOG00000023520 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000033726 ENTREZGENE
Gene3D-CATH 1.10.230.10 UniProtKB/Swiss-Prot
  1.10.580.10 UniProtKB/Swiss-Prot
InterPro Citrate_synth-like_lrg_a-sub UniProtKB/Swiss-Prot
  Citrate_synth-like_sm_a-sub UniProtKB/Swiss-Prot
  Citrate_synthase UniProtKB/Swiss-Prot
  Citrate_synthase_AS UniProtKB/Swiss-Prot
  Citrate_synthase_euk UniProtKB/Swiss-Prot
  Citrate_synthase_sf UniProtKB/Swiss-Prot
KEGG Report rno:170587 UniProtKB/Swiss-Prot
NCBI Gene 170587 ENTREZGENE
PANTHER CITRATE SYNTHASE, MITOCHONDRIAL UniProtKB/Swiss-Prot
  PTHR11739 UniProtKB/Swiss-Prot
Pfam Citrate_synt UniProtKB/Swiss-Prot
PhenoGen Cs PhenoGen
PRINTS CITRTSNTHASE UniProtKB/Swiss-Prot
PROSITE CITRATE_SYNTHASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000023520 RatGTEx
Superfamily-SCOP SSF48256 UniProtKB/Swiss-Prot
UniProt A0A8I6GES0_RAT UniProtKB/TrEMBL
  A0A8I6GLW2_RAT UniProtKB/TrEMBL
  CISY_RAT UniProtKB/Swiss-Prot
  G3V936 ENTREZGENE, UniProtKB/TrEMBL
  Q0QEL8_RAT UniProtKB/TrEMBL
  Q8VHF5 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Cs  citrate synthase      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Cs  citrate synthase      Symbol and Name status set to provisional 70820 PROVISIONAL