Gene: Acta2 (actin alpha 2, smooth muscle) Rattus norvegicus
Symbol: Acta2
Name: actin alpha 2, smooth muscle
Description: Predicted to have protein kinase binding activity; involved in several processes, including muscle contraction, positive regulation of ERK1 and ERK2 cascade, and positive regulation of cellular component movement; localizes to the cytoplasm and stress fiber; orthologous to human ACTA2 (actin alpha 2, smooth muscle); INTERACTS WITH (+)-Tetrandrine; (-)-epigallocatechin 3-gallate; (R)-lipoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: actin, alpha 2, smooth muscle, aorta; actin, aortic smooth muscle; alpha-actin-2; smooth muscle alpha-actin
Homo sapiens (human) : ACTA2 (actin alpha 2, smooth muscle)  HGNC  Alliance
Mus musculus (house mouse) : Acta2 (actin, alpha 2, smooth muscle, aorta)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Acta2 (actin alpha 2, smooth muscle)
Pan paniscus (bonobo/pygmy chimpanzee) : ACTA2 (actin alpha 2, smooth muscle)
Canis lupus familiaris (dog) : ACTA2 (actin alpha 2, smooth muscle)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Acta2 (actin alpha 2, smooth muscle)
Sus scrofa (pig) : ACTA2 (actin alpha 2, smooth muscle)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01252,537,614 - 252,550,394 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01259,760,521 - 259,773,301 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1228,860,239 - 228,873,019 (-)NCBICelera
Cytogenetic Map1q52NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
QTLs in Region (Rnor_6.0)


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Acta2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621676
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.