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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:(S)-nicotine
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Accession:CHEBI:17688 term browser browse the term
Definition:A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.
Synonyms:exact_synonym: 3-[(2S)-1-methylpyrrolidin-2-yl]pyridine
 related_synonym: (-)-3-(1-Methyl-2-pyrrolidyl)pyridine;   (-)-3-(N-Methylpyrrolidino)pyridine;   (R)-3-(1-Methyl-2-pyrrolidinyl)pyridine;   (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE;   (S)-3-(N-methylpyrrolidin-2-yl)pyridine;   1-Methyl-2-(3-pyridyl)pyrrolidine;   3-(1-Methyl-2-pyrollidinyl)pyridine;   3-(1-Methylpyrrolidin-2-yl)pyridine;   3-(2-(N-methylpyrrolidinyl))pyridine;   3-(N-methylpyrollidino)pyridine;   Formula=C10H14N2;   InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1;   InChIKey=SNICXCGAKADSCV-JTQLQIEISA-N;   L-3-(1-Methyl-2-pyrrolidyl)pyridine;   L-Nicotine;   Nicotine;   SMILES=C=1C=C([C@]2(N(CCC2)C)[H])C=NC1
 alt_id: CHEBI:14653;   CHEBI:25536;   CHEBI:44268;   CHEBI:7562
 xref: BPDB:485;   Beilstein:3604351;   Beilstein:82109;   CAS:54-11-5;   DrugBank:DB00184;   Drug_Central:1920;   HMDB:HMDB0001934;   KEGG:C00745;   KEGG:D03365;   KNApSAcK:C00002057;   LINCS:LSM-2093
 xref_mesh: MESH:D009538
 xref: MetaCyc:NICOTINE;   PDBeChem:NCT;   PMID:11209966;   PMID:11322615;   PMID:11406005;   PMID:11719700;   PMID:11768184;   PMID:11821649;   PMID:11851194;   PMID:12575980;   PMID:12692774;   PMID:12769614;   PMID:12850578;   PMID:12971663;   PMID:13590907;   PMID:14674846;   PMID:14761239;   PMID:14975706;   PMID:15019421;   PMID:15027713;   PMID:15251917;   PMID:15276225;   PMID:15380834;   PMID:15502843;   PMID:15527885;   PMID:15707677;   PMID:15734728;   PMID:15826609;   PMID:15894687;   PMID:15902919;   PMID:15960296;   PMID:15963341;   PMID:16059663;   PMID:16212709;   PMID:16333621;   PMID:16370520;   PMID:16496293;   PMID:17023324;   PMID:17206646;   PMID:17292347;   PMID:17350101;   PMID:17498763;   PMID:17504235;   PMID:17525204;   PMID:17560039;   PMID:17683794;   PMID:18380035;   PMID:18383130;   PMID:18490768;   PMID:18683238;   PMID:18685152;   PMID:18805442;   PMID:18922921;   PMID:19100291;   PMID:19100331;   PMID:19287496;   PMID:19389046;   PMID:19448649;   PMID:19465085;   PMID:19850423;   PMID:19954906;   PMID:21521420;   PMID:21636612;   PMID:21822688;   PMID:21945235;   PMID:21947355;   PMID:22030716;   PMID:22129149;   PMID:22218403;   PMID:22265518;   PMID:22331007;   PMID:22377934;   PMID:22459798;   PMID:22529223;   PMID:22530136;   PMID:27951416;   PMID:28187919;   PMID:28391535;   PMID:28574230;   PMID:28641297;   PMID:28678400;   PMID:28683421;   PMID:28686840;   PMID:28698187;   PMID:28700952;   PMID:28704277;   PMID:28710519;   PMID:28711472;   PMID:28714396;   PMID:28718768;   PMID:28718828;   PMID:28726253;   PMID:28735272;   Reaxys:82109;   Wikipedia:Nicotine
 cyclic_relationship: is_conjugate_base_of CHEBI:59806;   is_enantiomer_of CHEBI:39162


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(S)-nicotine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aacs acetoacetyl-CoA synthetase decreases expression
increases methylation
EXP Nicotine results in decreased expression of AACS mRNA
Nicotine results in increased methylation of AACS promoter
CTD PMID:26776438 NCBI chr12:31,113,098...31,156,411 JBrowse link
G Aatk apoptosis-associated tyrosine kinase increases expression ISO Nicotine results in increased expression of AATK mRNA CTD PMID:18247414 NCBI chr10:105,290,750...105,327,219 JBrowse link
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions
decreases expression
ISO
EXP
GW 3965 inhibits the reaction [Nicotine results in decreased expression of ABCA1 mRNA]; GW 3965 inhibits the reaction [Nicotine results in decreased expression of ABCA1 protein]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCA1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCA1 protein]
Nicotine results in decreased expression of ABCA1 mRNA; Nicotine results in decreased expression of ABCA1 protein
CTD PMID:30036686 NCBI chr 5:67,678,267...67,801,162 JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 multiple interactions
increases expression
decreases expression
ISO
EXP
GW 3965 inhibits the reaction [Nicotine results in decreased expression of ABCG1 mRNA]; GW 3965 inhibits the reaction [Nicotine results in decreased expression of ABCG1 protein]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCG1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCG1 protein]
Nicotine results in increased expression of ABCG1 protein
Nicotine results in decreased expression of ABCG1 mRNA; Nicotine results in decreased expression of ABCG1 protein
CTD PMID:30036686 PMID:31629012 NCBI chr20:9,126,687...9,182,948 JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases expression ISO Nicotine results in increased expression of ABCG2 mRNA CTD PMID:17997037 NCBI chr 4:87,676,241...87,802,757 JBrowse link
G Acaa2 acetyl-CoA acyltransferase 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ACAA2 mRNA; Nicotine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ACAA2 mRNA] CTD PMID:20230807 NCBI chr18:68,345,136...68,373,246 JBrowse link
G Acaca acetyl-CoA carboxylase alpha increases expression EXP Nicotine results in increased expression of ACACA mRNA CTD PMID:24368177 PMID:29155039 NCBI chr10:69,014,261...69,276,453 JBrowse link
G Acan aggrecan decreases expression EXP Nicotine results in decreased expression of ACAN mRNA CTD PMID:29660438 PMID:31299270 NCBI chr 1:132,981,034...133,044,416 JBrowse link
G Ace angiotensin I converting enzyme increases expression ISO Nicotine results in increased expression of ACE mRNA CTD PMID:11166759 NCBI chr10:90,910,316...90,930,437 JBrowse link
G Ache acetylcholinesterase decreases activity
increases activity
multiple interactions
EXP Nicotine results in decreased activity of ACHE protein
Nicotine results in increased activity of ACHE protein
Nicotine inhibits the reaction [Chlorpyrifos results in decreased activity of ACHE protein]
CTD PMID:20097188 PMID:21633116 PMID:23033686 NCBI chr12:19,407,359...19,413,713 JBrowse link
G Acot13 acyl-CoA thioesterase 13 decreases expression ISO Nicotine results in decreased expression of ACOT13 mRNA CTD PMID:17997037 NCBI chr17:40,240,378...40,252,851 JBrowse link
G Acp1 acid phosphatase 1 decreases expression ISO Nicotine results in decreased expression of ACP1 mRNA CTD PMID:17997037 NCBI chr 6:47,506,380...47,522,021 JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 increases splicing ISO Nicotine results in increased splicing of ACSL1 mRNA alternative form CTD PMID:23825647 NCBI chr16:45,755,246...45,821,541 JBrowse link
G Acsl6 acyl-CoA synthetase long-chain family member 6 multiple interactions
increases expression
ISO
EXP
Mecamylamine inhibits the reaction [Nicotine results in increased expression of ACSL6 protein]
Nicotine results in increased expression of ACSL6 mRNA
CTD PMID:22205969 NCBI chr10:38,439,914...38,501,182 JBrowse link
G Acta1 actin, alpha 1, skeletal muscle increases expression
decreases expression
ISO
EXP
Nicotine results in increased expression of ACTA1 mRNA
Nicotine results in decreased expression of ACTA1 mRNA
CTD PMID:17997037 PMID:27782041 NCBI chr19:51,883,713...51,886,725 JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] CTD PMID:33640489 NCBI chr 1:231,746,527...231,759,307 JBrowse link
G Actb actin, beta increases expression ISO Nicotine results in increased expression of ACTB mRNA CTD PMID:17997037 NCBI chr12:11,663,112...11,666,697 JBrowse link
G Actr1a actin related protein 1A multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ACTR1A mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ACTR1A mRNA] CTD PMID:20230807 NCBI chr 1:245,237,821...245,256,618 JBrowse link
G Actrt2 actin-related protein T2 decreases expression EXP Nicotine results in decreased expression of ACTRT2 mRNA CTD PMID:27782041 NCBI chr 5:165,236,092...165,237,492 JBrowse link
G Ada adenosine deaminase multiple interactions
increases activity
EXP Sodium Acetate inhibits the reaction [Nicotine results in increased activity of ADA protein] CTD PMID:31857090 NCBI chr 3:152,398,745...152,422,854 JBrowse link
G Adam19 ADAM metallopeptidase domain 19 increases expression ISO Nicotine results in increased expression of ADAM19 mRNA CTD PMID:23825647 NCBI chr10:30,491,362...30,583,115 JBrowse link
G Adcy7 adenylate cyclase 7 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ADCY7 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ADCY7 mRNA] CTD PMID:20230807 NCBI chr19:18,740,875...18,798,924 JBrowse link
G Adgra1 adhesion G protein-coupled receptor A1 decreases expression ISO Nicotine results in decreased expression of ADGRA1 mRNA CTD PMID:21955143 NCBI chr 1:194,629,744...194,673,254 JBrowse link
G Adgrg1 adhesion G protein-coupled receptor G1 increases expression ISO Nicotine results in increased expression of ADGRG1 mRNA CTD PMID:23825647 NCBI chr19:10,003,963...10,041,122 JBrowse link
G Adgrl1 adhesion G protein-coupled receptor L1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ADGRL1 mRNA; Nicotine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ADGRL1 mRNA] CTD PMID:20230807 NCBI chr19:24,202,405...24,244,137 JBrowse link
G Adipor2 adiponectin receptor 2 increases expression EXP Nicotine results in increased expression of ADIPOR2 mRNA CTD PMID:22265867 NCBI chr 4:152,524,604...152,588,848 JBrowse link
G Adk adenosine kinase increases expression ISO Nicotine results in increased expression of ADK mRNA CTD PMID:17997037 NCBI chr15:2,863,241...3,246,453 JBrowse link
G Adm2 adrenomedullin 2 multiple interactions EXP [Cholecalciferol co-treated with Nicotine] results in decreased expression of ADM2 protein CTD PMID:19910445 NCBI chr 7:120,393,219...120,394,965 JBrowse link
G Adnp activity-dependent neuroprotector homeobox multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ADNP mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ADNP mRNA] CTD PMID:20230807 NCBI chr 3:156,886,921...156,921,500 JBrowse link
G Adora2a adenosine A2a receptor decreases expression ISO Nicotine results in decreased expression of ADORA2A mRNA CTD PMID:21955143 NCBI chr20:13,315,848...13,333,386 JBrowse link
G Adrb1 adrenoceptor beta 1 multiple interactions
increases expression
ISO [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]; [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [Atenolol binds to and results in decreased activity of ADRB1 protein] which results in decreased susceptibility to Nicotine
Nicotine results in increased expression of ADRB1 mRNA
CTD PMID:17003101 PMID:17369603 NCBI chr 1:255,772,217...255,773,617 JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions
increases expression
ISO [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased abundance of Dinoprostone]; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2]; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] which results in decreased susceptibility to Nicotine
Nicotine results in increased expression of ADRB2 mRNA
CTD PMID:17003101 PMID:17369603 NCBI chr18:55,642,459...55,644,501 JBrowse link
G Adtrp androgen-dependent TFPI-regulating protein increases expression ISO Nicotine results in increased expression of ADTRP mRNA CTD PMID:23825647 NCBI chr17:22,930,012...22,993,834 JBrowse link
G Agtr1a angiotensin II receptor, type 1a increases expression EXP Nicotine results in increased expression of AGTR1A protein CTD PMID:22691361 NCBI chr17:34,173,446...34,226,892 JBrowse link
G Agtr1b angiotensin II receptor, type 1b increases expression EXP Nicotine results in increased expression of AGTR1B mRNA CTD PMID:22728133 NCBI chr 2:102,844,969...102,920,232 JBrowse link
G Agtr2 angiotensin II receptor, type 2 decreases expression
affects expression
EXP Nicotine results in decreased expression of AGTR2 mRNA; Nicotine results in decreased expression of AGTR2 protein
Nicotine affects the expression of AGTR2 protein
CTD PMID:19429393 PMID:22691361 NCBI chr  X:112,119,673...112,124,060 JBrowse link
G Ak3 adenylate kinase 3 increases expression ISO Nicotine results in increased expression of AK3 mRNA CTD PMID:17456735 NCBI chr 1:226,737,472...226,764,647 JBrowse link
G Ak5 adenylate kinase 5 increases expression ISO Nicotine results in increased expression of AK5 mRNA CTD PMID:21955143 NCBI chr 2:241,397,297...241,581,483 JBrowse link
G Akr1a1 aldo-keto reductase family 1 member A1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of AKR1A1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of AKR1A1 mRNA] CTD PMID:20230807 NCBI chr 5:130,092,945...130,130,277 JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases expression
decreases phosphorylation
increases phosphorylation
ISO
EXP
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein]; [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of EIF4EBP1 protein; [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of FOXO1 protein; [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of GSK3A protein; [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of GSK3B protein; Curcumin inhibits the reaction [Nicotine results in increased expression of AKT1 protein modified form]; Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein]; Nicotine affects the reaction [Camptothecin affects the phosphorylation of AKT1 protein]; Nicotine affects the reaction [Fluorouracil affects the phosphorylation of AKT1 protein]; Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein
Nicotine results in increased expression of AKT1 mRNA
Nicotine results in decreased phosphorylation of AKT1 protein
Nicotine results in increased phosphorylation of AKT1 protein
CTD PMID:12511591 PMID:15983034 PMID:20727180 PMID:24095863 PMID:30836163 PMID:31783125 PMID:31945395 NCBI chr 6:131,713,716...131,735,319 JBrowse link
G Akt2 AKT serine/threonine kinase 2 affects expression
increases expression
EXP
ISO
Nicotine affects the expression of AKT2 mRNA
Nicotine results in increased expression of AKT2 mRNA
CTD PMID:31945395 PMID:31972234 NCBI chr 1:82,877,228...82,933,828 JBrowse link
G Alad aminolevulinate dehydratase decreases activity ISO Nicotine results in decreased activity of ALAD protein CTD PMID:8687997 NCBI chr 5:75,961,993...75,972,334 JBrowse link
G Alb albumin increases expression EXP Nicotine results in increased expression of ALB protein CTD PMID:25662863 NCBI chr14:17,607,397...17,622,814 JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases activity
multiple interactions
ISO Nicotine results in increased activity of ALDH1A1 protein
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ALDH1A1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ALDH1A1 mRNA]
CTD PMID:20230807 PMID:23219715 NCBI chr 1:218,000,470...218,152,962 JBrowse link
G Alox12 arachidonate 12-lipoxygenase, 12S type increases expression ISO Nicotine results in increased expression of ALOX12 mRNA CTD PMID:16254210 NCBI chr10:54,958,263...54,970,542 JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions
increases expression
ISO [RTKI cpd co-treated with AG 1879] inhibits the reaction [Nicotine results in increased expression of ALOX5 protein]; AG 1879 inhibits the reaction [Nicotine results in increased expression of ALOX5 protein]; MK-886 inhibits the reaction [Nicotine results in increased expression of ALOX5 protein]; RTKI cpd inhibits the reaction [Nicotine results in increased expression of ALOX5 protein]; U 0126 inhibits the reaction [Nicotine results in increased expression of ALOX5 mRNA]
Nicotine results in increased expression of ALOX5 mRNA; Nicotine results in increased expression of ALOX5 protein
CTD PMID:14569062 PMID:20061081 NCBI chr 4:149,531,329...149,578,696 JBrowse link
G Amd1 adenosylmethionine decarboxylase 1 increases expression ISO Nicotine results in increased expression of AMD1 mRNA CTD PMID:16949557 NCBI chr20:43,695,783...43,711,476 JBrowse link
G Amhr2 anti-Mullerian hormone receptor type 2 decreases expression ISO Nicotine results in decreased expression of AMHR2 mRNA CTD PMID:18247414 NCBI chr 7:133,579,152...133,588,874 JBrowse link
G Angpt4 angiopoietin 4 increases expression ISO Nicotine results in increased expression of ANGPT4 mRNA CTD PMID:23825647 NCBI chr 3:140,420,389...140,454,213 JBrowse link
G Angptl4 angiopoietin-like 4 decreases expression EXP Nicotine results in decreased expression of ANGPTL4 mRNA CTD PMID:32512034 NCBI chr 7:14,550,288...14,557,797 JBrowse link
G Ano3 anoctamin 3 decreases expression ISO Nicotine results in decreased expression of ANO3 mRNA CTD PMID:21955143 NCBI chr 3:97,235,671...97,550,090 JBrowse link
G Anxa1 annexin A1 decreases expression EXP Nicotine results in decreased expression of ANXA1 mRNA CTD PMID:26776438 NCBI chr 1:217,861,175...217,877,205 JBrowse link
G Apeh acylaminoacyl-peptide hydrolase decreases expression ISO Nicotine results in decreased expression of APEH mRNA CTD PMID:16949557 NCBI chr 8:108,773,791...108,782,903 JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of APEX1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of APEX1 mRNA] CTD PMID:20230807 NCBI chr15:24,144,595...24,146,785 JBrowse link
G Api5 apoptosis inhibitor 5 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of API5 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of API5 mRNA] CTD PMID:20230807 NCBI chr 3:80,378,100...80,403,267 JBrowse link
G Apoe apolipoprotein E increases expression ISO Nicotine results in increased expression of APOE mRNA CTD PMID:17997037 NCBI chr 1:79,353,924...79,357,852 JBrowse link
G App amyloid beta precursor protein multiple interactions
increases metabolic processing
decreases expression
ISO
EXP
[Nicotine results in increased metabolism of APP protein] which results in increased secretion of APP protein modified form; Bungarotoxins inhibits the reaction [Nicotine inhibits the reaction [Copper results in increased expression of APP protein]]; Mecamylamine inhibits the reaction [Nicotine inhibits the reaction [Copper results in increased expression of APP protein]]; Nicotine inhibits the reaction [Copper promotes the reaction [APP protein binds to APP protein]]; Nicotine inhibits the reaction [Copper results in increased expression of APP mRNA]; Nicotine inhibits the reaction [Copper results in increased expression of APP protein]; Tubocurarine inhibits the reaction [[Nicotine results in increased metabolism of APP protein] which results in increased secretion of APP protein modified form]; Tubocurarine inhibits the reaction [Nicotine results in increased metabolism of APP protein]
APP protein modified form inhibits the reaction [Nicotine results in increased secretion of Acetylcholine]; spiro(imidazo-(1,2-a)pyridine-3,2-indan)-2(3H)-one inhibits the reaction [APP protein modified form inhibits the reaction [Nicotine results in increased secretion of Acetylcholine]]
Nicotine results in decreased expression of APP protein alternative form
Nicotine results in decreased expression of APP mRNA; Nicotine results in decreased expression of APP protein
CTD PMID:16474004 PMID:16627626 PMID:17135361 PMID:29618714 NCBI chr11:24,019,774...24,236,584 JBrowse link
G Aqp4 aquaporin 4 increases expression ISO Nicotine results in increased expression of AQP4 mRNA CTD PMID:21955143 NCBI chr18:6,507,903...6,524,558 JBrowse link
G Arc activity-regulated cytoskeleton-associated protein increases expression ISO Nicotine results in increased expression of ARC mRNA CTD PMID:23825647 NCBI chr 7:106,555,968...106,559,697 JBrowse link
G Arf1 ADP-ribosylation factor 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ARF1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ARF1 mRNA] CTD PMID:20230807 NCBI chr10:43,997,983...44,014,543 JBrowse link
G Arf3 ADP-ribosylation factor 3 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ARF3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ARF3 mRNA] CTD PMID:20230807 NCBI chr 7:129,886,082...129,912,022 JBrowse link
G Arglu1 arginine and glutamate rich 1 increases expression ISO Nicotine results in increased expression of ARGLU1 mRNA CTD PMID:16949557 NCBI chr16:80,753,300...80,777,350 JBrowse link
G Arhgef26 Rho guanine nucleotide exchange factor 26 multiple interactions ISO [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of ARHGEF26 mRNA CTD PMID:28065790 NCBI chr 2:146,740,336...146,850,918 JBrowse link
G Arhgef7 Rho guanine nucleotide exchange factor 7 decreases expression ISO Nicotine results in decreased expression of ARHGEF7 mRNA CTD PMID:12588870 NCBI chr16:77,671,021...77,782,593 JBrowse link
G Arid1a AT-rich interaction domain 1A decreases expression ISO Nicotine results in decreased expression of ARID1A mRNA CTD PMID:17997037 NCBI chr 5:145,908,181...145,981,609 JBrowse link
G Arl15 ADP-ribosylation factor like GTPase 15 multiple interactions ISO [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of ARL15 mRNA CTD PMID:28065790 NCBI chr 2:45,438,221...45,822,562 JBrowse link
G Arpp21 cAMP regulated phosphoprotein 21 decreases expression ISO Nicotine results in decreased expression of ARPP21 mRNA CTD PMID:21955143 NCBI chr 8:112,034,636...112,199,273 JBrowse link
G Arrb1 arrestin, beta 1 multiple interactions ISO ARRB1 protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]; ARRB1 protein affects the reaction [Nicotine results in increased phosphorylation of and results in increased activity of SRC protein] CTD PMID:16862215 NCBI chr 1:153,837,964...153,912,111 JBrowse link
G Ascl1 achaete-scute family bHLH transcription factor 1 decreases expression EXP Nicotine results in decreased expression of ASCL1 mRNA CTD PMID:28555334 NCBI chr 7:21,904,153...21,906,003 JBrowse link
G Ascl2 achaete-scute family bHLH transcription factor 2 decreases expression EXP Nicotine results in decreased expression of ASCL2 mRNA CTD PMID:24368670 NCBI chr 1:198,148,999...198,151,406 JBrowse link
G Aspm assembly factor for spindle microtubules multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ASPM mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ASPM mRNA] CTD PMID:20230807 NCBI chr13:51,074,849...51,123,755 JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Nicotine results in increased expression of ATF3 mRNA CTD PMID:17456735 PMID:24927667 NCBI chr13:102,751,278...102,800,520 JBrowse link
G Atf6 activating transcription factor 6 multiple interactions EXP Nicotine inhibits the reaction [Tunicamycin results in increased expression of ATF6 protein] CTD PMID:18477628 NCBI chr13:82,927,579...83,106,381 JBrowse link
G Atm ATM serine/threonine kinase multiple interactions ISO Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of ATM protein modified form] CTD PMID:23907605 NCBI chr 8:53,828,741...53,932,773 JBrowse link
G Atoh1 atonal bHLH transcription factor 1 multiple interactions
increases expression
ISO Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in increased expression of ATOH1 mRNA] CTD PMID:23056257 NCBI chr 4:93,912,068...93,914,163 JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha decreases expression EXP Nicotine results in decreased expression of ATP5A1 protein CTD PMID:28681937 NCBI chr18:71,292,406...71,300,342 JBrowse link
G Atp5f1e ATP synthase F1 subunit epsilon increases splicing ISO Nicotine results in increased splicing of ATP5F1E mRNA alternative form CTD PMID:23825647 NCBI chr 3:163,259,072...163,261,974 JBrowse link
G Atp6v0a4 ATPase H+ transporting V0 subunit a4 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ATP6V0A4 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ATP6V0A4 mRNA] CTD PMID:20230807 NCBI chr 4:66,760,159...66,842,110 JBrowse link
G Atp9a ATPase phospholipid transporting 9A (putative) multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ATP9A mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ATP9A mRNA] CTD PMID:20230807 NCBI chr 3:157,360,354...157,467,628 JBrowse link
G Atr ATR serine/threonine kinase multiple interactions ISO Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of ATR protein modified form] CTD PMID:23907605 NCBI chr 8:96,426,704...96,524,152 JBrowse link
G Atrn attractin multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ATRN mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ATRN mRNA] CTD PMID:20230807 NCBI chr 3:118,110,320...118,244,326 JBrowse link
G Atrx ATRX, chromatin remodeler increases expression
decreases expression
ISO Nicotine results in increased expression of ATRX mRNA
Nicotine results in decreased expression of ATRX mRNA
CTD PMID:16949557 PMID:21955143 NCBI chr  X:70,850,981...70,997,330 JBrowse link
G Avp arginine vasopressin decreases expression
increases secretion
ISO
EXP
Nicotine results in decreased expression of AVP mRNA
Nicotine results in increased secretion of AVP protein alternative form
CTD PMID:3681699 PMID:17456735 PMID:28555334 NCBI chr 3:117,793,447...117,805,091 JBrowse link
G B4galt2 beta-1,4-galactosyltransferase 2 decreases expression ISO Nicotine results in decreased expression of B4GALT2 mRNA CTD PMID:17997037 NCBI chr 5:131,412,541...131,422,573 JBrowse link
G Bad BCL2-associated agonist of cell death decreases expression
decreases phosphorylation
ISO
EXP
Nicotine results in decreased expression of BAD mRNA
Nicotine results in decreased phosphorylation of BAD protein
CTD PMID:18247414 PMID:20447445 NCBI chr 1:204,133,502...204,142,829 JBrowse link
G Bap1 Brca1 associated protein 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of BAP1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of BAP1 mRNA] CTD PMID:20230807 NCBI chr16:6,446,709...6,455,535 JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases phosphorylation
increases expression
multiple interactions
affects localization
decreases expression
ISO
EXP
Nicotine results in increased phosphorylation of BAX protein
Nicotine results in increased expression of BAX protein
Folic Acid inhibits the reaction [Nicotine results in increased expression of BAX protein]
Nicotine results in increased expression of BAX mRNA; Nicotine results in increased expression of BAX protein
Nicotine affects the localization of BAX protein
Nicotine results in decreased expression of BAX mRNA; Nicotine results in decreased expression of BAX protein
3-methyladenine inhibits the reaction [Nicotine results in increased expression of BAX protein]; [Nicotine co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in decreased expression of BAX protein; MK-886 inhibits the reaction [Nicotine results in decreased expression of BAX protein]; Nicotine inhibits the reaction [[Cisplatin co-treated with Etoposide] affects the localization of BAX protein]; PRKCZ protein affects the reaction [Nicotine results in increased phosphorylation of BAX protein]
CTD PMID:15831280 PMID:17135361 PMID:17525161 PMID:18203686 PMID:18676776 PMID:20061081 PMID:20106947 PMID:20339300 PMID:29972271 PMID:30259641 PMID:31783125 PMID:33010382 NCBI chr 1:95,940,001...95,945,407 JBrowse link
G Bcas1 brain enriched myelin associated protein 1 increases expression ISO Nicotine results in increased expression of BCAS1 mRNA CTD PMID:21955143 NCBI chr 3:159,136,233...159,211,925 JBrowse link
G Bcl11b BAF chromatin remodeling complex subunit BCL11B increases expression ISO Nicotine results in increased expression of BCL11B mRNA CTD PMID:21955143 NCBI chr 6:126,834,531...126,927,720 JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
increases expression
increases phosphorylation
ISO
EXP
3-methyladenine inhibits the reaction [Nicotine results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of BCL2 protein]; edelfosine inhibits the reaction [Nicotine results in increased phosphorylation of BCL2 protein]; EIF4E protein affects the reaction [Nicotine results in increased expression of BCL2 protein]; MK-886 inhibits the reaction [Nicotine results in increased expression of BCL2 protein]; Nicotine inhibits the reaction [Aflatoxin B1 results in decreased expression of BCL2 protein]
royal jelly inhibits the reaction [Nicotine results in decreased expression of BCL2 mRNA]
Folic Acid inhibits the reaction [Nicotine results in decreased expression of BCL2 protein]
Nicotine results in decreased expression of BCL2 mRNA; Nicotine results in decreased expression of BCL2 protein
Nicotine results in increased expression of BCL2 mRNA; Nicotine results in increased expression of BCL2 protein; Nicotine results in increased expression of BCL2 protein modified form
CTD PMID:12421819 PMID:15831280 PMID:18448488 PMID:18676776 PMID:20061081 PMID:20339300 PMID:20727180 PMID:22743290 PMID:29972271 PMID:30076938 PMID:30836163 PMID:30896085 PMID:31783125 PMID:33010382 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2a1 BCL2-related protein A1 decreases expression ISO Nicotine results in decreased expression of BCL2A1 mRNA CTD PMID:18247414 NCBI chr 8:89,716,914...89,724,998 JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression
multiple interactions
ISO Nicotine results in decreased expression of BCL2L1 mRNA
resveratrol inhibits the reaction [Nicotine results in decreased expression of BCL2L1 mRNA]
CTD PMID:22687363 NCBI chr 3:141,253,508...141,304,582 JBrowse link
G Bcl2l10 BCL2 like 10 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of BCL2L10 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of BCL2L10 mRNA] CTD PMID:20230807 NCBI chr 8:76,107,326...76,113,373 JBrowse link
G Bdnf brain-derived neurotrophic factor affects response to substance
increases expression
affects expression
increases secretion
multiple interactions
ISO
EXP
BDNF gene polymorphism affects the susceptibility to Nicotine
Nicotine results in increased expression of BDNF mRNA
Nicotine affects the expression of BDNF mRNA
Nicotine results in increased secretion of BDNF protein
methyllycaconitine inhibits the reaction [Nicotine results in increased secretion of BDNF protein]
CTD PMID:9503263 PMID:9832142 PMID:16790237 PMID:17186223 PMID:20426880 NCBI chr 3:96,165,042...96,215,621 JBrowse link
G Becn1 beclin 1 increases expression
multiple interactions
ISO Nicotine results in increased expression of BECN1 mRNA
Nicotine promotes the reaction [Dextran Sulfate results in increased expression of BECN1 protein]
dorsomorphin inhibits the reaction [Nicotine promotes the reaction [Dextran Sulfate results in increased expression of BECN1 protein]]; Nicotine promotes the reaction [Dextran Sulfate results in increased expression of BECN1 protein]
CTD PMID:30605750 PMID:31926917 NCBI chr10:86,231,387...86,246,742 JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression
decreases expression
multiple interactions
ISO
EXP
Nicotine results in increased expression of BGLAP
Nicotine results in decreased expression of BGLAP mRNA
Tubocurarine inhibits the reaction [Nicotine results in increased expression of BGLAP]
CTD PMID:19436947 PMID:29981921 NCBI chr 2:173,838,518...173,839,495 JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 increases expression
multiple interactions
ISO Nicotine results in increased expression of BIRC2 protein
Curcumin inhibits the reaction [Nicotine results in increased expression of BIRC2 protein]
CTD PMID:20727180 NCBI chr 8:4,968,856...4,989,325 JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
increases expression
ISO Curcumin inhibits the reaction [Nicotine results in increased expression of BIRC5 protein]; Hexamethonium affects the reaction [Nicotine results in increased expression of BIRC5 protein]; Nicotine inhibits the reaction [RB1 protein binds to BIRC5 promoter]; Nicotine promotes the reaction [E2F1 protein binds to BIRC5 promoter]
Nicotine results in increased expression of BIRC5 mRNA; Nicotine results in increased expression of BIRC5 protein
CTD PMID:16601104 PMID:19896492 PMID:20727180 PMID:21267677 NCBI chr10:103,072,530...103,081,382 JBrowse link
G Bmi1 BMI1 proto-oncogene, polycomb ring finger increases expression
multiple interactions
ISO Nicotine results in increased expression of BMI1 mRNA; Nicotine results in increased expression of BMI1 protein
SNAI1 mutant form inhibits the reaction [Nicotine results in increased expression of BMI1 mRNA]
CTD PMID:23219715 NCBI chr17:81,332,175...81,341,625 JBrowse link
G Bmp4 bone morphogenetic protein 4 decreases expression EXP Nicotine results in decreased expression of BMP4 mRNA CTD PMID:20339300 NCBI chr15:19,618,538...19,633,494 JBrowse link
G Bmp7 bone morphogenetic protein 7 multiple interactions ISO [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of CS mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of HGF mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of MMP2 mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of PPARGC1A mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of PPARGC1A protein; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of PRDM16 mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of UCP1 mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of UCP1 protein; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of VEGFA mRNA CTD PMID:33091441 NCBI chr 3:161,639,915...161,716,938 JBrowse link
G Bnip3 BCL2 interacting protein 3 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of BNIP3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of BNIP3 mRNA] CTD PMID:20230807 NCBI chr 1:193,708,164...193,725,348 JBrowse link
G Bok BCL2 family apoptosis regulator BOK decreases expression ISO Nicotine results in decreased expression of BOK mRNA CTD PMID:21955143 NCBI chr 9:94,223,493...94,234,476 JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase decreases expression ISO Nicotine results in decreased expression of BRAF mRNA; Nicotine results in decreased expression of BRAF protein CTD PMID:17135361 NCBI chr 4:68,375,484...68,510,652 JBrowse link
G Brca1 BRCA1, DNA repair associated decreases expression
multiple interactions
ISO Nicotine results in decreased expression of BRCA1 mRNA
Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of BRCA1 protein modified form]
CTD PMID:18247414 PMID:23907605 NCBI chr10:86,417,441...86,477,762 JBrowse link
G Btbd11 BTB domain containing 11 increases expression ISO Nicotine results in increased expression of BTBD11 mRNA CTD PMID:21955143 PMID:23825647 NCBI chr 7:18,035,151...18,310,718 JBrowse link
G Btf3 basic transcription factor 3 decreases expression ISO Nicotine results in decreased expression of BTF3 mRNA CTD PMID:18247414 NCBI chr 2:29,659,764...29,666,898 JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression ISO Nicotine results in increased expression of BTG2 mRNA CTD PMID:17456735 NCBI chr13:45,531,881...45,535,642 JBrowse link
G Btk Bruton tyrosine kinase decreases expression ISO Nicotine results in decreased expression of BTK mRNA CTD PMID:18247414 NCBI chr  X:97,722,796...97,762,315 JBrowse link
G C1r complement C1r multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of C1R mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of C1R mRNA] CTD PMID:20230807 NCBI chr 4:157,412,718...157,423,483 JBrowse link
G C3ar1 complement C3a receptor 1 increases expression ISO Nicotine results in increased expression of C3AR1 mRNA CTD PMID:23825647 NCBI chr 4:156,074,747...156,084,680 JBrowse link
G C5ar1 complement C5a receptor 1 decreases expression ISO Nicotine results in decreased expression of C5AR1 mRNA CTD PMID:18247414 NCBI chr 1:76,948,622...76,959,826 JBrowse link
G C7 complement C7 multiple interactions
increases expression
ISO alpha-cobratoxin inhibits the reaction [Nicotine results in increased expression of C7 mRNA]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of C7 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of C7 mRNA] CTD PMID:16949557 NCBI chr 2:54,088,116...54,165,102 JBrowse link
G Ca3 carbonic anhydrase 3 decreases expression EXP Nicotine results in decreased expression of CAR3 mRNA CTD PMID:27782041 NCBI chr 2:86,770,418...86,780,011 JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C increases expression ISO Nicotine results in increased expression of CACNA1C protein CTD PMID:11756415 NCBI chr 4:151,764,138...152,379,454 JBrowse link
G Cacna1d calcium voltage-gated channel subunit alpha1 D increases expression ISO Nicotine results in increased expression of CACNA1D protein CTD PMID:11756415 NCBI chr16:5,227,157...5,521,163 JBrowse link
G Cacna1f calcium voltage-gated channel subunit alpha1 F increases expression ISO Nicotine results in increased expression of CACNA1F mRNA CTD PMID:11756415 NCBI chr  X:14,868,096...14,896,413 JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H increases expression EXP Nicotine results in increased expression of CACNA1H mRNA CTD PMID:27782041 NCBI chr10:14,390,104...14,448,204 JBrowse link
G Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 increases expression ISO Nicotine results in increased expression of CACNA2D1 protein CTD PMID:11756415 NCBI chr 4:18,950,611...19,374,969 JBrowse link
G Cacng1 calcium voltage-gated channel auxiliary subunit gamma 1 decreases expression EXP Nicotine results in decreased expression of CACNG1 mRNA CTD PMID:27782041 NCBI chr10:92,652,924...92,665,612 JBrowse link
G Cadm3 cell adhesion molecule 3 increases expression EXP Nicotine results in increased expression of CADM3 mRNA CTD PMID:27782041 NCBI chr13:85,786,482...85,817,412 JBrowse link
G Calb1 calbindin 1 increases expression
multiple interactions
EXP Nicotine results in increased expression of CALB1 protein
Mecamylamine inhibits the reaction [Nicotine results in increased expression of CALB1 protein]
CTD PMID:11226671 NCBI chr 5:29,375,624...29,402,532 JBrowse link
G Calcrl calcitonin receptor like receptor multiple interactions EXP [Cholecalciferol co-treated with Nicotine] results in increased expression of CALCRL protein CTD PMID:19910445 NCBI chr 3:69,428,348...69,525,910 JBrowse link
G Calm1 calmodulin 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CALM1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CALM1 mRNA] CTD PMID:20230807 NCBI chr 6:119,487,691...119,495,759 JBrowse link
G Calr calreticulin increases expression ISO Nicotine results in increased expression of CALR mRNA CTD PMID:16949557 NCBI chr19:23,308,525...23,313,420 JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha increases expression ISO Nicotine results in increased expression of CAMK2A mRNA CTD PMID:21955143 NCBI chr18:54,378,642...54,441,120 JBrowse link
G Camk4 calcium/calmodulin-dependent protein kinase IV decreases expression ISO Nicotine results in decreased expression of CAMK4 mRNA CTD PMID:17997037 NCBI chr18:24,582,988...24,811,918 JBrowse link
G Camp cathelicidin antimicrobial peptide increases expression ISO Nicotine results in increased expression of CAMP mRNA CTD PMID:23825647 NCBI chr 8:109,841,729...109,843,543 JBrowse link
G Cap1 cyclase associated actin cytoskeleton regulatory protein 1 decreases expression ISO Nicotine results in decreased expression of CAP1 mRNA CTD PMID:21955143 NCBI chr 5:135,142,108...135,168,885 JBrowse link
G Capn10 calpain 10 increases expression ISO Nicotine results in increased expression of CAPN10 mRNA CTD PMID:17997037 NCBI chr 9:93,498,132...93,510,494 JBrowse link
G Capza2 capping actin protein of muscle Z-line subunit alpha 2 increases expression ISO Nicotine results in increased expression of CAPZA2 mRNA CTD PMID:16949557 NCBI chr 4:45,978,142...46,014,032 JBrowse link
G Cartpt CART prepropeptide decreases expression EXP
ISO
Nicotine results in decreased expression of CARTPT protein
Nicotine results in decreased expression of CARTPT mRNA
CTD PMID:18247414 PMID:23623838 NCBI chr 2:31,255,098...31,257,452 JBrowse link
G Casp1 caspase 1 multiple interactions ISO Nicotine affects the reaction [Staurosporine affects the localization of CASP1 protein]; Nicotine inhibits the reaction [Staurosporine results in increased activity of CASP1 protein] CTD PMID:16927020 NCBI chr 8:2,587,812...2,597,403 JBrowse link
G Casp12 caspase 12 multiple interactions ISO
EXP
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CASP12 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CASP12 mRNA]
Nicotine inhibits the reaction [Tunicamycin results in increased activity of CASP12 protein]
CTD PMID:18477628 PMID:20230807 NCBI chr 8:2,642,296...2,669,549 JBrowse link
G Casp14 caspase 14 increases expression ISO Nicotine results in increased expression of CASP14 mRNA CTD PMID:23825647 NCBI chr 7:10,929,759...10,932,591 JBrowse link
G Casp2 caspase 2 affects expression EXP Nicotine affects the expression of CASP2 mRNA CTD PMID:20426880 NCBI chr 4:71,149,632...71,167,388 JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity
increases expression
affects expression
decreases expression
decreases activity
ISO
EXP
geldanamycin inhibits the reaction [Nicotine results in increased activity of CASP3 protein]; MK-886 inhibits the reaction [Nicotine results in decreased expression of CASP3 protein]; Nicotine inhibits the reaction [Aflatoxin B1 results in increased cleavage of CASP3 protein]; Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of CASP3 protein modified form]; Nicotine inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; Nicotine inhibits the reaction [Paclitaxel results in increased activity of CASP3 protein]
Nicotine results in increased cleavage of CASP3 protein
Nicotine results in increased activity of CASP3 protein; Nicotine results in increased activity of CASP3 protein alternative form
Nicotine results in increased expression of CASP3 mRNA; Nicotine results in increased expression of CASP3 protein
Nicotine affects the expression of CASP3 mRNA
[Ethanol co-treated with Nicotine] results in increased expression of CASP3 protein; Nicotine inhibits the reaction [Ethanol results in increased activity of CASP3 protein]
Nicotine results in increased expression of CASP3 mRNA; Nicotine results in increased expression of CASP3 protein modified form
Nicotine results in increased expression of CASP3; Nicotine results in increased expression of CASP3 mRNA; Nicotine results in increased expression of CASP3 protein; Nicotine results in increased expression of CASP3 protein modified form
Nicotine results in decreased expression of CASP3 mRNA; Nicotine results in decreased expression of CASP3 protein
[Nicotine co-treated with Polylactic Acid-Polyglycolic Acid Copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CASP3 protein]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CASP3 protein]; Resveratrol inhibits the reaction [Nicotine results in increased expression of CASP3 mRNA]; royal jelly inhibits the reaction [Nicotine results in increased expression of CASP3 mRNA]
Nicotine results in decreased activity of CASP3 protein
CTD PMID:11701223 PMID:12115584 PMID:12218695 PMID:15831280 PMID:16237857 PMID:16949557 PMID:17135361 PMID:18203686 PMID:19815060 PMID:20061081 PMID:20106947 PMID:20383341 PMID:20426880 PMID:20447445 PMID:20457658 PMID:22687363 PMID:22743290 PMID:23907605 PMID:23933227 PMID:30896085 PMID:30959089 PMID:31678612 PMID:31783125 PMID:33010382 NCBI chr16:45,662,910...45,681,171 JBrowse link
G Casp8 caspase 8 affects expression EXP Nicotine affects the expression of CASP8 mRNA CTD PMID:20426880 NCBI chr 9:60,263,863...60,312,542 JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression
decreases expression
ISO
EXP
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CASP9 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CASP9 mRNA]
Nicotine results in increased expression of CASP9 protein
Folic Acid inhibits the reaction [Nicotine results in increased expression of CASP9 protein]
Nicotine inhibits the reaction [[Cisplatin co-treated with Etoposide] results in increased activity of CASP9 protein]
Nicotine results in decreased expression of CASP9 mRNA
CTD PMID:16949557 PMID:18676776 PMID:20230807 PMID:29972271 NCBI chr 5:154,108,872...154,126,628 JBrowse link
G Cat catalase multiple interactions
decreases activity
increases activity
EXP
ISO
[acephate co-treated with methamidophos co-treated with Nicotine] results in increased activity of CAT protein; [Ethanol co-treated with Nicotine] results in decreased activity of CAT protein; [Ethanol co-treated with Nicotine] results in increased activity of CAT protein; Folic Acid inhibits the reaction [Nicotine results in decreased activity of CAT protein]
royal jelly inhibits the reaction [Nicotine results in decreased activity of CAT protein]
Nicotine results in increased activity of CAT protein
CTD PMID:10509436 PMID:10874619 PMID:10906423 PMID:11747978 PMID:15925865 PMID:23033686 PMID:25662863 PMID:29972271 PMID:30896085 NCBI chr 3:89,842,393...89,874,577 JBrowse link
G Cav2 caveolin 2 decreases expression ISO Nicotine results in decreased expression of CAV2 mRNA CTD PMID:33640489 NCBI chr 4:45,616,766...45,624,144 JBrowse link
G Cbl Cbl proto-oncogene increases expression ISO Nicotine results in increased expression of CBL mRNA CTD PMID:18247414 NCBI chr 8:44,487,824...44,571,620 JBrowse link
G Cbln1 cerebellin 1 precursor increases expression ISO Nicotine results in increased expression of CBLN1 mRNA CTD PMID:21955143 NCBI chr19:19,608,763...19,612,572 JBrowse link
G Cbx3 chromobox 3 increases expression ISO Nicotine results in increased expression of CBX3 mRNA CTD PMID:16949557 NCBI chr 4:80,545,450...80,559,284 JBrowse link
G Cbx5 chromobox 5 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CBX5 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CBX5 mRNA] CTD PMID:20230807 NCBI chr 7:134,333,165...134,376,102 JBrowse link
G Ccdc136 coiled-coil domain containing 136 increases expression ISO Nicotine results in increased expression of CCDC136 mRNA CTD PMID:21955143 NCBI chr 4:57,997,825...58,027,598 JBrowse link
G Ccdc159 coiled-coil domain containing 159 increases expression ISO Nicotine results in increased expression of CCDC159 mRNA CTD PMID:23825647 NCBI chr 8:20,457,905...20,467,232 JBrowse link
G Ccdc167 coiled-coil domain containing 167 increases expression ISO Nicotine results in increased expression of CCDC167 mRNA CTD PMID:23825647 NCBI chr20:7,763,927...7,782,090 JBrowse link
G Ccdc88a coiled coil domain containing 88A increases expression ISO Nicotine results in increased expression of CCDC88A mRNA CTD PMID:17456735 NCBI chr14:103,104,091...103,256,112 JBrowse link
G Cck cholecystokinin decreases expression ISO Nicotine results in decreased expression of CCK mRNA CTD PMID:21955143 NCBI chr 8:121,153,499...121,160,194 JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases expression
decreases secretion
ISO
EXP
Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]; ZFP36 mutant form inhibits the reaction [Nicotine results in decreased expression of CCL2 mRNA]
Nicotine results in decreased expression of CCL2 mRNA; Nicotine results in decreased expression of CCL2 protein
Nicotine results in decreased secretion of CCL2 protein
Mecamylamine inhibits the reaction [Nicotine results in decreased expression of CCL2 mRNA]
CTD PMID:15135227 PMID:15976189 PMID:22093924 NCBI chr10:67,005,424...67,007,222 JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases expression ISO Nicotine results in increased expression of CCL5 mRNA CTD PMID:18247414 NCBI chr10:68,322,826...68,327,365 JBrowse link
G Ccn1 cellular communication network factor 1 increases expression ISO Nicotine results in increased expression of CCN1 mRNA CTD PMID:17456735 NCBI chr 2:234,562,410...234,565,370 JBrowse link
G Ccn2 cellular communication network factor 2 increases expression EXP Nicotine results in increased expression of CCN2 protein CTD PMID:22691361 NCBI chr 1:20,802,199...20,805,315 JBrowse link
G Ccn5 cellular communication network factor 5 increases expression ISO Nicotine results in increased expression of CCN5 mRNA CTD PMID:23825647 NCBI chr 3:152,491,247...152,502,639 JBrowse link
G Ccna2 cyclin A2 increases expression ISO Nicotine results in increased expression of CCNA2 protein CTD PMID:18448488 PMID:20106947 NCBI chr 2:119,427,239...119,433,645 JBrowse link
G Ccnb1 cyclin B1 increases expression
multiple interactions
ISO Nicotine results in increased expression of CCNB1 protein
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CCNB1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CCNB1 mRNA]
CTD PMID:20106947 PMID:20230807 NCBI chr 2:31,912,190...31,921,163 JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression
decreases expression
increases activity
ISO
EXP
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Nicotine results in increased expression of CCND1 protein]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Nicotine results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of CCND1 protein]; EIF4E protein affects the reaction [Nicotine results in increased expression of CCND1 protein]; MK-886 inhibits the reaction [Nicotine results in increased expression of CCND1 mRNA]; MK-886 inhibits the reaction [Nicotine results in increased expression of CCND1 protein]; Nicotine promotes the reaction [CDK4 protein binds to CCND1 protein]; Nicotine promotes the reaction [CDK6 protein binds to CCND1 protein]; U 0126 inhibits the reaction [Nicotine results in increased expression of CCND1 protein]
Nicotine results in decreased expression of CCND1 mRNA; Nicotine results in decreased expression of CCND1 protein
Nicotine results in increased activity of CCND1 promoter
Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in decreased expression of CCND1 mRNA]
Nicotine results in increased expression of CCND1 mRNA; Nicotine results in increased expression of CCND1 protein
CTD PMID:15574422 PMID:15983034 PMID:17135361 PMID:18448488 PMID:18805435 PMID:18835254 PMID:20061081 PMID:20106947 PMID:20727180 PMID:23056257 PMID:30836163 NCBI chr 1:200,089,002...200,098,524 JBrowse link
G Ccnd2 cyclin D2 multiple interactions
decreases expression
ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CCND2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CCND2 mRNA]
Nicotine results in decreased expression of CCND2 protein
CTD PMID:15231866 PMID:20230807 NCBI chr 4:159,966,883...159,989,261 JBrowse link
G Ccne1 cyclin E1 multiple interactions
increases expression
ISO MK-886 inhibits the reaction [Nicotine results in increased expression of CCNE1 protein] CTD PMID:20061081 NCBI chr 1:90,781,947...90,791,188 JBrowse link
G Ccng2 cyclin G2 increases expression ISO Nicotine results in increased expression of CCNG2 mRNA CTD PMID:23416264 NCBI chr14:14,804,321...14,812,819 JBrowse link
G Ccnl2 cyclin L2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CCNL2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CCNL2 mRNA] CTD PMID:20230807 NCBI chr 5:166,416,940...166,428,997 JBrowse link
G Ccr5 C-C motif chemokine receptor 5 increases expression ISO Nicotine results in increased expression of CCR5 mRNA CTD PMID:18247414 NCBI chr 8:123,752,423...123,757,538 JBrowse link
G Ccr6 C-C motif chemokine receptor 6 decreases expression ISO Nicotine results in decreased expression of CCR6 mRNA CTD PMID:18247414 NCBI chr 1:52,474,477...52,508,301 JBrowse link
G Ccs copper chaperone for superoxide dismutase increases expression ISO Nicotine results in increased expression of CCS protein CTD PMID:16627626 NCBI chr 1:202,113,792...202,134,931 JBrowse link
G Cd151 CD151 molecule (Raph blood group) multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CD151 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CD151 mRNA] CTD PMID:20230807 NCBI chr 1:196,564,744...196,568,753 JBrowse link
G Cd4 Cd4 molecule decreases expression ISO Nicotine results in decreased expression of CD4 mRNA CTD PMID:18247414 NCBI chr 4:157,668,878...157,695,366 JBrowse link
G Cd44 CD44 molecule (Indian blood group) multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CD44 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CD44 mRNA] CTD PMID:20230807 NCBI chr 3:89,155,850...89,244,615 JBrowse link
G Cd46 CD46 molecule increases expression ISO Nicotine results in increased expression of CD46 mRNA CTD PMID:16949557 NCBI chr13:106,575,586...106,606,325 JBrowse link
G Cd59 CD59 molecule increases expression ISO Nicotine results in increased expression of CD59 mRNA CTD PMID:18247414 NCBI chr 3:90,459,085...90,477,571 JBrowse link
G Cd68 Cd68 molecule multiple interactions EXP [Nicotine results in increased abundance of Cotinine] which results in increased expression of CD68 mRNA CTD PMID:29617909 NCBI chr10:54,381,814...54,383,693 JBrowse link
G Cd86 CD86 molecule increases expression EXP Nicotine results in increased expression of CD86 mRNA CTD PMID:27782041 NCBI chr11:64,142,193...64,200,816 JBrowse link
G Cd9 CD9 molecule multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CD9 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CD9 mRNA] CTD PMID:20230807 NCBI chr 4:158,256,328...158,289,136 JBrowse link
G Cdc25a cell division cycle 25A multiple interactions ISO Nicotine inhibits the reaction [E2F4 protein binds to CDC25A promoter]; Nicotine inhibits the reaction [E2F5 protein binds to CDC25A promoter]; Nicotine inhibits the reaction [RB1 protein binds to CDC25A promoter]; Nicotine inhibits the reaction [RBL1 protein binds to CDC25A promoter]; Nicotine inhibits the reaction [RBL2 protein binds to CDC25A promoter]; Nicotine promotes the reaction [E2F1 protein binds to CDC25A promoter]; Nicotine promotes the reaction [E2F2 protein binds to CDC25A promoter]; Nicotine promotes the reaction [E2F3 protein binds to CDC25A promoter] CTD PMID:16862215 NCBI chr 8:109,864,356...109,882,734 JBrowse link
G Cdc42 cell division cycle 42 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CDC42 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CDC42 mRNA] CTD PMID:20230807 NCBI chr 5:149,555,069...149,593,239 JBrowse link
G Cdc6 cell division cycle 6 multiple interactions ISO Nicotine inhibits the reaction [E2F4 protein binds to CDC6 promoter]; Nicotine inhibits the reaction [E2F5 protein binds to CDC6 promoter]; Nicotine inhibits the reaction [RB1 protein binds to CDC6 promoter]; Nicotine inhibits the reaction [RBL1 protein binds to CDC6 promoter]; Nicotine inhibits the reaction [RBL2 protein binds to CDC6 promoter]; Nicotine promotes the reaction [E2F1 protein binds to CDC6 promoter]; Nicotine promotes the reaction [E2F2 protein binds to CDC6 promoter]; Nicotine promotes the reaction [E2F3 protein binds to CDC6 promoter] CTD PMID:16862215 NCBI chr10:83,864,189...83,878,011 JBrowse link
G Cdh1 cadherin 1 multiple interactions
decreases expression
ISO MK-886 inhibits the reaction [Nicotine results in decreased expression of CDH1 mRNA]; U 0126 inhibits the reaction [Nicotine results in decreased expression of CDH1 mRNA]
Nicotine results in decreased expression of CDH1 mRNA; Nicotine results in decreased expression of CDH1 protein
CTD PMID:18844224 PMID:20061081 PMID:23219715 NCBI chr19:34,492,371...34,561,775 JBrowse link
G Cdh11 cadherin 11 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CDH11 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CDH11 mRNA] CTD PMID:20230807 NCBI chr19:2,148,447...2,305,754 JBrowse link
G Cdk13 cyclin-dependent kinase 13 increases expression ISO Nicotine results in increased expression of CDK13 mRNA CTD PMID:16949557 NCBI chr17:47,251,145...47,344,675 JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions
decreases expression
ISO Bungarotoxins inhibits the reaction [Nicotine results in decreased expression of CDK4 protein]; Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in decreased expression of CDK4 protein]; Hexamethonium inhibits the reaction [Nicotine results in decreased expression of CDK4 protein]; Nicotine promotes the reaction [CDK4 protein binds to CCND1 protein]; Nicotine promotes the reaction [NFATC2 protein results in decreased expression of CDK4 protein]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of CDK4 protein]
Nicotine results in decreased expression of CDK4 mRNA; Nicotine results in decreased expression of CDK4 protein
CTD PMID:15231866 PMID:17135361 PMID:18805435 NCBI chr 7:62,885,647...62,889,562 JBrowse link
G Cdk6 cyclin-dependent kinase 6 multiple interactions
increases expression
ISO Nicotine promotes the reaction [CDK6 protein binds to CCND1 protein]
Nicotine results in increased expression of CDK6 mRNA
CTD PMID:16949557 PMID:18805435 NCBI chr 4:30,637,650...30,829,688 JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression
multiple interactions
increases expression
ISO Nicotine results in decreased expression of CDKN1A protein
Acetylcysteine inhibits the reaction [Nicotine results in increased expression of CDKN1A mRNA]; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of CDKN1A protein]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of CDKN1A mRNA]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of CDKN1A protein]
Nicotine results in increased expression of CDKN1A mRNA; Nicotine results in increased expression of CDKN1A protein
4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide inhibits the reaction [Nicotine results in decreased expression of CDKN1A protein]; Nicotine inhibits the reaction [Cisplatin results in increased expression of CDKN1A protein]; Nicotine inhibits the reaction [gemcitabine results in increased expression of CDKN1A protein]; Nicotine inhibits the reaction [Paclitaxel results in increased expression of CDKN1A protein]
CTD PMID:16011614 PMID:16601104 PMID:18805435 PMID:20727180 PMID:30272249 PMID:31507073 PMID:32473187 NCBI chr20:7,149,177...7,159,727 JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression
multiple interactions
ISO Nicotine results in decreased expression of CDKN1B protein
4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide inhibits the reaction [Nicotine results in decreased expression of CDKN1B protein]; Nicotine results in increased expression of and results in increased stability of CDKN1B protein
CTD PMID:15231866 PMID:18805435 NCBI chr 4:167,760,067...167,765,177 JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [Nicotine results in increased expression of CDKN2A mRNA]; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of CDKN2A protein]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of CDKN2A mRNA]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of CDKN2A protein]
Nicotine results in increased expression of CDKN2A mRNA; Nicotine results in increased expression of CDKN2A protein
CTD PMID:32473187 NCBI chr 5:103,984,949...103,992,143 JBrowse link
G Cds1 CDP-diacylglycerol synthase 1 increases splicing ISO Nicotine results in increased splicing of CDS1 mRNA alternative form CTD PMID:23825647 NCBI chr14:7,820,328...7,882,943 JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 increases expression ISO Nicotine results in increased expression of CEACAM1 mRNA CTD PMID:17997037 NCBI chr 1:81,043,595...81,060,050 JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions
affects expression
increases expression
EXP
ISO
[Nicotine results in increased abundance of Cotinine] which results in increased expression of CEBPA protein
Nicotine affects the expression of CEBPA mRNA
Nicotine results in increased expression of CEBPA mRNA
CTD PMID:29617909 PMID:31622651 PMID:31972234 NCBI chr 1:87,759,631...87,762,303 JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression
multiple interactions
ISO
EXP
Nicotine results in increased expression of CEBPB mRNA
[Nicotine results in increased abundance of Cotinine] which results in increased expression of CEBPB mRNA
CTD PMID:18805435 PMID:29617909 NCBI chr 3:156,398,035...156,399,466 JBrowse link
G Celf6 CUGBP, Elav-like family member 6 increases expression EXP Nicotine results in increased expression of CELF6 mRNA CTD PMID:27782041 NCBI chr 8:59,975,095...60,006,060 JBrowse link
G Cenpe centromere protein E increases expression ISO Nicotine results in increased expression of CENPE mRNA CTD PMID:16949557 NCBI chr 2:223,637,035...223,695,692 JBrowse link
G Cers6 ceramide synthase 6 multiple interactions ISO [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of CERS6 mRNA CTD PMID:28065790 NCBI chr 3:53,630,636...53,879,692 JBrowse link
G Cetn2 centrin 2 decreases expression ISO Nicotine results in decreased expression of CETN2 mRNA CTD PMID:17997037 NCBI chr  X:150,769,944...150,775,052 JBrowse link
G Cetn3 centrin 3 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CETN3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CETN3 mRNA] CTD PMID:20230807 NCBI chr 2:12,089,025...12,101,828 JBrowse link
G Cfap43 cilia and flagella associated protein 43 decreases expression ISO Nicotine results in decreased expression of CFAP43 mRNA CTD PMID:23825647 NCBI chr 1:246,625,259...246,712,438 JBrowse link
G Cga glycoprotein hormones, alpha polypeptide increases expression ISO Nicotine results in increased expression of CGA mRNA CTD PMID:23825647 NCBI chr 5:49,486,915...49,499,192 JBrowse link
G Cgref1 cell growth regulator with EF hand domain 1 increases expression ISO Nicotine results in increased expression of CGREF1 mRNA CTD PMID:23825647 NCBI chr 6:25,431,846...25,443,853 JBrowse link
G Chat choline O-acetyltransferase multiple interactions
increases activity
decreases activity
EXP Nicotine inhibits the reaction [Vanadium results in decreased expression of CHAT protein]; Nicotine promotes the reaction [Bucladesine results in increased expression of CHAT protein]
Nicotine results in increased activity of CHAT protein
Nicotine results in decreased activity of CHAT protein
CTD PMID:20361958 PMID:21633116 PMID:22119111 PMID:30247698 NCBI chr16:7,657,362...7,717,093 JBrowse link
G Chd2 chromodomain helicase DNA binding protein 2 increases expression ISO Nicotine results in increased expression of CHD2 mRNA CTD PMID:16949557 NCBI chr 1:127,188,146...127,317,041 JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions ISO Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of CHEK2 protein modified form] CTD PMID:23907605 NCBI chr12:45,788,823...45,821,382 JBrowse link
G Chga chromogranin A multiple interactions
increases activity
increases expression
ISO
EXP
CHGA protein alternative form inhibits the reaction [Nicotine results in increased activity of CHGA promoter]; Chlorisondamine inhibits the reaction [Nicotine results in increased activity of CHGA promoter]
Nicotine results in increased expression of CHGA mRNA
CTD PMID:1907749 PMID:12799369 NCBI chr 6:121,696,051...121,707,399 JBrowse link
G Chgb chromogranin B increases expression EXP Nicotine results in increased expression of CHGB mRNA; Nicotine results in increased expression of CHGB protein CTD PMID:1907749 NCBI chr 3:120,043,824...120,057,169 JBrowse link
G Chrna1 cholinergic receptor nicotinic alpha 1 subunit multiple interactions
affects binding
ISO PLAU inhibits the reaction [Nicotine binds to CHRNA1 protein] CTD PMID:19690163 NCBI chr 3:58,454,763...58,469,832 JBrowse link
G Chrna10 cholinergic receptor nicotinic alpha 10 subunit increases expression EXP Nicotine results in increased expression of CHRNA10 mRNA CTD PMID:30959089 PMID:31846720 NCBI chr 1:156,487,279...156,494,277 JBrowse link
G Chrna2 cholinergic receptor nicotinic alpha 2 subunit affects response to substance
multiple interactions
ISO CHRNA2 gene mutant form affects the susceptibility to Nicotine
Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]
CTD PMID:9454827 PMID:19383498 NCBI chr15:40,342,317...40,358,601 JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit decreases expression
increases activity
multiple interactions
increases expression
affects response to substance
ISO
EXP
Nicotine results in decreased expression of CHRNA3 mRNA
Nicotine results in increased activity of CHRNA3 protein
Cocaine inhibits the reaction [Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Nicotine analog binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]; Nicotine binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]; Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]; Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]
Nicotine results in increased expression of CHRNA3 mRNA
CHRNA3 protein affects the susceptibility to Nicotine
CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA5 protein]; CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA7 protein]; Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]
CTD PMID:9454827 PMID:10336510 PMID:11600638 PMID:12628473 PMID:15275829 PMID:15615518 PMID:17135361 PMID:18450646 PMID:19483072 PMID:29293602 NCBI chr 8:55,401,981...55,415,012 JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit affects binding
increases expression
decreases expression
multiple interactions
increases response to substance
affects response to substance
ISO
EXP
Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein]
Nicotine results in increased expression of CHRNA4 mRNA
Nicotine results in decreased expression of CHRNA4 mRNA
Nicotine analog binds to [CHRNA4 protein binds to CHRNB2 protein]; Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein]
1-(5-azido-6-chloropyridin-3-ylmethyl)-2-nitroiminoimidazolidine inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]]; [Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in decreased susceptibility to Nicotine; [Nicotine co-treated with Benzo(a)pyrene] results in decreased expression of [CHRNA4 protein binds to CHRNB2 protein]; Cocaine inhibits the reaction [Nicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Dihydro-beta-Erythroidine analog inhibits the reaction [Nicotine results in increased expression of CHRNA4 mRNA]; imidacloprid analog inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]]; N-(5-azido-6-chloropyridin-3-ylmethyl)-N'-methyl-N''-nitroguanidine inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]]; Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]; Nicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Nicotine results in increased expression of [CHRNA4 protein binds to CHRNB2 protein]
Nicotine results in increased expression of CHRNA4 mRNA; Nicotine results in increased expression of CHRNA4 protein
[N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide co-treated with Nicotine] inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in increased expression of CHRNA4 protein]; cytisine inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein]; Hexamethonium inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein]; Nicotine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CHRNA4 protein]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein]
CHRNA4 protein mutant form results in increased susceptibility to Nicotine
CHRNA4 gene polymorphism affects the susceptibility to Nicotine; CHRNA4 protein affects the susceptibility to Nicotine; CHRNA4 protein mutant form affects the susceptibility to Nicotine
[CHRNA4 protein binds to CHRNB2 protein] which results in increased susceptibility to Nicotine; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Nicotine inhibits the reaction [cytisine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Nicotine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Nicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA4 protein]; Rosiglitazone inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein]
CTD PMID:7756618 PMID:9336329 PMID:9454827 PMID:10336510 PMID:10377228 PMID:10734154 PMID:10942032 PMID:10945867 PMID:11124396 PMID:11150171 PMID:14500745 PMID:14645658 PMID:15551346 PMID:15615518 PMID:16339034 PMID:16915382 PMID:17135361 PMID:18448488 PMID:19139119 PMID:19252481 PMID:19404753 PMID:19481067 PMID:19594327 PMID:20060465 PMID:20106947 PMID:20943775 PMID:24368670 PMID:28555334 PMID:29293602 PMID:29486207 PMID:30247698 PMID:31846720 NCBI chr 3:168,136,246...168,157,839 JBrowse link
G Chrna5 cholinergic receptor nicotinic alpha 5 subunit increases response to substance
increases expression
affects response to substance
decreases expression
multiple interactions
ISO CHRNA5 gene polymorphism results in increased susceptibility to Nicotine
Nicotine results in increased expression of CHRNA5 mRNA
CHRNA5 gene polymorphism affects the susceptibility to Nicotine
Nicotine results in increased expression of CHRNA5 mRNA; Nicotine results in increased expression of CHRNA5 protein
Nicotine results in decreased expression of CHRNA5 mRNA
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]; 5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; 5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]; alpha-conotoxin MII inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; alpha-conotoxin MII inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]; CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA5 protein]; CHRNA5 mutant form inhibits the reaction [Nicotine results in increased expression of HIF1A protein]; CHRNA5 mutant form inhibits the reaction [Nicotine results in increased expression of VEGFA protein]; CHRNA7 protein affects the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; CHRNA7 protein affects the reaction [Nicotine results in increased expression of CHRNA5 protein]; Go 6976 inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; Go 6976 inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]; KN 62 inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; KN 62 inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]; manumycin inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; manumycin inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]
CTD PMID:9495872 PMID:12628473 PMID:18450646 PMID:18519132 PMID:24793809 PMID:29293602 PMID:29486207 NCBI chr 8:55,369,794...55,398,526 JBrowse link
G Chrna6 cholinergic receptor nicotinic alpha 6 subunit decreases expression
increases expression
multiple interactions
affects response to substance
ISO Nicotine results in decreased expression of CHRNA6 mRNA
Nicotine results in increased expression of CHRNA6 mRNA
Nicotine inhibits the reaction [[CHRNA6 protein binds to CHRNB2 protein] which results in increased secretion of Dopamine]; Nicotine inhibits the reaction [Paraquat results in decreased expression of [CHRNA6 protein binds to CHRNB2 protein]]
CHRNA6 gene polymorphism affects the susceptibility to Nicotine
CTD PMID:10734154 PMID:12628473 PMID:17227438 PMID:29293602 PMID:30959089 NCBI chr16:64,697,741...64,704,441 JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit increases response to substance
increases expression
affects activity
increases activity
decreases expression
multiple interactions
affects response to substance
ISO
EXP
CHRNA7 protein mutant form results in increased susceptibility to Nicotine
Nicotine results in increased expression of CHRNA7 mRNA; Nicotine results in increased expression of CHRNA7 protein
Nicotine affects the activity of CHRNA7 protein
Nicotine results in increased activity of CHRNA7 protein
Nicotine results in decreased expression of CHRNA7 mRNA; Nicotine results in decreased expression of CHRNA7 protein
[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which affects the susceptibility to Nicotine; [Nicotine co-treated with Butylhydroxybutylnitrosamine] results in increased expression of CHRNA7 protein; [Nicotine results in increased activity of CHRNA7 protein] which results in increased transport of Calcium; Nicotine inhibits the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein]; Nicotine inhibits the reaction [methyllycaconitine binds to CHRNA7 protein]; Nicotine results in increased expression of and results in increased phosphorylation of CHRNA7 protein
[Bungarotoxins results in decreased activity of CHRNA7 protein] which results in decreased susceptibility to Nicotine; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which results in decreased susceptibility to Nicotine; [triethyl-(beta-4-stilbenoxyethyl)ammonium results in decreased activity of CHRNA7 protein] which results in decreased susceptibility to Nicotine
CHRNA7 gene polymorphism affects the susceptibility to Nicotine; CHRNA7 protein affects the susceptibility to Nicotine
Nicotine results in increased expression of CHRNA7; Nicotine results in increased expression of CHRNA7 mRNA; Nicotine results in increased expression of CHRNA7 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine results in increased expression of CHRNA7 protein]; 1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea promotes the reaction [Nicotine affects the activity of CHRNA7 protein]; 1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea promotes the reaction [Nicotine results in increased activity of CHRNA7 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Nicotine results in increased expression of CHRNA7 protein]; [GATA4 co-treated with GATA6] affects the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased abundance of Epinephrine]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of DBH mRNA]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of TH mRNA]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; [Nicotine results in increased activity of CHRNA7 protein] which results in increased transport of Calcium; Bungarotoxins inhibits the reaction [Nicotine binds to and results in increased activity of CHRNA7 protein]; Bungarotoxins inhibits the reaction [Nicotine results in increased expression of CHRNA7 protein]; CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA7 protein]; CHRNA7 protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]; CHRNA7 protein affects the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; CHRNA7 protein affects the reaction [Nicotine results in increased expression of CHRNA5 protein]; CHRNA7 protein affects the reaction [Nicotine results in increased expression of GATA2 mRNA]; CHRNA7 protein affects the reaction [Nicotine results in increased expression of GATA2 protein]; GATA2 protein affects the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; GATA2 protein affects the reaction [Nicotine results in increased expression of CHRNA7 protein]; KN 62 inhibits the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; KN 62 inhibits the reaction [Nicotine results in increased expression of CHRNA7 protein]; MB327 analog promotes the reaction [Nicotine affects the activity of CHRNA7 protein]; MB327 promotes the reaction [Nicotine affects the activity of CHRNA7 protein]; MB327 promotes the reaction [Nicotine results in increased activity of CHRNA7 protein]; methyllycaconitine inhibits the reaction [Nicotine binds to and results in increased activity of CHRNA7 protein]; methyllycaconitine promotes the reaction [[Nicotine results in increased activity of CHRNA7 protein] which results in increased transport of Calcium]; Nicotine binds to and results in increased activity of CHRNA7 protein; Nicotine inhibits the reaction [Bungarotoxins binds to CHRNA7 protein]; Nicotine promotes the reaction [[GATA4 protein binds to SP1 protein] which binds to CHRNA7 protein]; Nicotine promotes the reaction [[GATA6 protein binds to SP1 protein] which binds to CHRNA7 protein]; Nicotine promotes the reaction [GATA6 protein binds to GATA4 protein binds to SP1 protein binds to CHRNA7 promoter]; Nicotine results in increased expression of and results in increased phosphorylation of CHRNA7 protein; Pyridinium Compounds analog promotes the reaction [Nicotine results in increased activity of CHRNA7 protein]
CTD PMID:9336329 PMID:9495872 PMID:10082212 PMID:10216184 PMID:10942032 PMID:11854451 PMID:11893908 PMID:12626641 PMID:12628473 PMID:14500745 PMID:16862215 PMID:17135361 PMID:17151781 PMID:17218065 PMID:17241116 PMID:17459420 PMID:17498763 PMID:17709503 PMID:18385335 PMID:18448488 PMID:18450646 PMID:19448648 PMID:20060465 PMID:20106947 PMID:24089524 PMID:24380835 PMID:27329243 PMID:29191791 PMID:29248576 PMID:29293602 PMID:29501575 PMID:30959089 PMID:31622651 PMID:31846720 NCBI chr 1:116,715,286...116,837,223 JBrowse link
G Chrna9 cholinergic receptor nicotinic alpha 9 subunit increases expression
multiple interactions
ISO Nicotine results in increased expression of CHRNA9 mRNA
[Nicotine co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of CHRNA9 protein
CTD PMID:29486207 PMID:30259641 PMID:30959089 PMID:31846720 NCBI chr14:42,235,218...42,241,939 JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions
increases expression
decreases expression
affects binding
affects response to substance
ISO
EXP
[CHRNA4 protein binds to CHRNB2 protein] which results in increased susceptibility to Nicotine; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Nicotine inhibits the reaction [cytisine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Nicotine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Nicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]
Nicotine results in increased expression of CHRNB2 mRNA
1-(5-azido-6-chloropyridin-3-ylmethyl)-2-nitroiminoimidazolidine inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]]; [Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in decreased susceptibility to Nicotine; [Nicotine co-treated with Benzo(a)pyrene] results in decreased expression of [CHRNA4 protein binds to CHRNB2 protein]; Cocaine inhibits the reaction [Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Cocaine inhibits the reaction [Nicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; imidacloprid analog inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]]; N-(5-azido-6-chloropyridin-3-ylmethyl)-N'-methyl-N''-nitroguanidine inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]]; Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]; Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]; Nicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Nicotine results in increased activity of [NACHRA1 protein co-treated with CHRNB2 protein]; Nicotine results in increased expression of [CHRNA4 protein binds to CHRNB2 protein]
Nicotine results in decreased expression of CHRNB2 mRNA
Nicotine analog binds to [CHRNA4 protein binds to CHRNB2 protein]; Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein]
Nicotine results in increased expression of CHRNB2 mRNA; Nicotine results in increased expression of CHRNB2 protein
CHRNB2 protein affects the susceptibility to Nicotine
CHRNB2 promotes the reaction [Nicotine results in increased expression of RYR2 mRNA]; cytisine inhibits the reaction [Nicotine results in increased expression of CHRNB2 protein]; Hexamethonium inhibits the reaction [Nicotine results in increased expression of CHRNB2 protein]; Nicotine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Nicotine inhibits the reaction [[CHRNA6 protein binds to CHRNB2 protein] which results in increased secretion of Dopamine]; Nicotine inhibits the reaction [Paraquat results in decreased expression of [CHRNA6 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of CHRNB2 protein]
CTD PMID:7756618 PMID:9336329 PMID:10336510 PMID:10377228 PMID:10945867 PMID:11124396 PMID:11150171 PMID:14645658 PMID:14982698 PMID:15615518 PMID:16915382 PMID:16981889 PMID:17227438 PMID:18448488 PMID:19252481 PMID:19481067 PMID:20060465 PMID:20457658 PMID:20943775 PMID:21113126 PMID:28555334 PMID:29293602 PMID:29486207 PMID:30247698 PMID:31846720 NCBI chr 2:175,181,402...175,189,619 JBrowse link
G Chrnb3 cholinergic receptor nicotinic beta 3 subunit increases expression EXP Nicotine results in increased expression of CHRNB3 mRNA CTD PMID:30959089 NCBI chr16:64,713,438...64,751,360 JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit multiple interactions
increases expression
increases activity
affects response to substance
ISO
EXP
Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]; Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]; Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA4 protein]
Nicotine results in increased expression of CHRNB4 mRNA
Nicotine results in increased activity of CHRNB4 protein
Nicotine analog binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]; Nicotine binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]; Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]
CHRNB4 protein affects the susceptibility to Nicotine
CTD PMID:9454827 PMID:11600638 PMID:15275829 PMID:15615518 PMID:19483072 PMID:29293602 NCBI chr 8:55,418,379...55,436,967 JBrowse link
G Ciao1 cytosolic iron-sulfur assembly component 1 decreases expression EXP Nicotine results in decreased expression of CIAO1 mRNA CTD PMID:11478936 NCBI chr 3:114,458,671...114,465,928 JBrowse link
G Cib1 calcium and integrin binding 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CIB1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CIB1 mRNA] CTD PMID:20230807 NCBI chr 1:134,178,331...134,183,895 JBrowse link
G Cidea cell death-inducing DFFA-like effector a decreases expression EXP Nicotine results in decreased expression of CIDEA mRNA CTD PMID:33091441 NCBI chr18:60,894,917...60,920,485 JBrowse link
G Cirbp cold inducible RNA binding protein increases expression ISO Nicotine results in increased expression of CIRBP mRNA CTD PMID:21955143 NCBI chr 7:9,533,857...9,538,899 JBrowse link
G Ckmt1 creatine kinase, mitochondrial 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CKMT1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CKMT1 mRNA] CTD PMID:20230807 NCBI chr 3:108,329,859...108,335,760 JBrowse link
G Ckmt2 creatine kinase, mitochondrial 2 decreases expression ISO Nicotine results in decreased expression of CKMT2 mRNA CTD PMID:16949557 NCBI chr 2:23,079,920...23,110,518 JBrowse link
G Cks1b CDC28 protein kinase regulatory subunit 1B decreases expression ISO Nicotine results in decreased expression of CKS1B mRNA CTD PMID:18247414 NCBI chr 2:174,833,025...174,837,614 JBrowse link
G Cks2 CDC28 protein kinase regulatory subunit 2 increases expression ISO Nicotine results in increased expression of CKS2 mRNA CTD PMID:16949557 NCBI chr17:13,570,611...13,575,770 JBrowse link
G Clca2 chloride channel accessory 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CLCA2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CLCA2 mRNA] CTD PMID:20230807 NCBI chr 2:233,993,619...234,022,691 JBrowse link
G Clcc1 chloride channel CLIC-like 1 increases expression ISO Nicotine results in increased expression of CLCC1 mRNA CTD PMID:16949557 NCBI chr 2:196,296,350...196,326,914 JBrowse link
G Clcn3 chloride voltage-gated channel 3 increases expression ISO Nicotine results in increased expression of CLCN3 mRNA CTD PMID:16949557 NCBI chr16:29,127,419...29,200,133 JBrowse link
G Cldn4 claudin 4 increases expression
decreases expression
ISO Nicotine results in increased expression of CLDN4 protein
Nicotine results in decreased expression of CLDN4 protein
CTD PMID:31783125 NCBI chr12:21,751,638...21,753,436 JBrowse link
G Clic1 chloride intracellular channel 1 decreases expression ISO Nicotine results in decreased expression of CLIC1 mRNA CTD PMID:16949557 NCBI chr20:3,764,867...3,773,711 JBrowse link
G Clmp CXADR-like membrane protein increases expression ISO Nicotine results in increased expression of CLMP mRNA CTD PMID:23825647 NCBI chr 8:41,060,527...41,168,841 JBrowse link
G Clstn1 calsyntenin 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CLSTN1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CLSTN1 mRNA] CTD PMID:20230807 NCBI chr 5:160,031,235...160,094,585 JBrowse link
G Cmtm5 CKLF-like MARVEL transmembrane domain containing 5 decreases expression ISO Nicotine results in decreased expression of CMTM5 mRNA CTD PMID:21955143 NCBI chr15:28,412,624...28,415,304 JBrowse link
G Cnn2 calponin 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CNN2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CNN2 mRNA] CTD PMID:20230807 NCBI chr 7:9,712,505...9,719,711 JBrowse link
G Cnr1 cannabinoid receptor 1 affects response to substance
increases expression
multiple interactions
ISO CNR1 protein affects the susceptibility to Nicotine
Nicotine results in increased expression of CNR1 mRNA
[rimonabant binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to Nicotine
CTD PMID:12384171 PMID:16416159 PMID:21955143 NCBI chr 5:48,408,543...48,436,099 JBrowse link
G Cntn1 contactin 1 decreases expression
increases expression
multiple interactions
ISO Nicotine results in decreased expression of CNTN1 mRNA
Nicotine results in increased expression of CNTN1 mRNA
alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of CNTN1 mRNA]; alpha-cobratoxin inhibits the reaction [Nicotine results in increased expression of CNTN1 mRNA]; Mecamylamine inhibits the reaction [Nicotine results in decreased expression of CNTN1 mRNA]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of CNTN1 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of CNTN1 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of CNTN1 mRNA]
CTD PMID:12588870 PMID:16949557 NCBI chr 7:123,263,146...123,560,896 JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
increases expression
ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of COL1A1 mRNA; NGF protein affects the reaction [Nicotine results in increased expression of COL1A1 mRNA]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of COL1A1 mRNA]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of COL1A1 protein]; Nicotine promotes the reaction [Thioacetamide results in increased expression of COL1A1] CTD PMID:20230807 PMID:28440100 PMID:33082140 PMID:33640489 NCBI chr10:79,883,622...79,900,625 JBrowse link
G Col2a1 collagen type II alpha 1 chain decreases expression EXP Nicotine results in decreased expression of COL2A1 mRNA; Nicotine results in decreased expression of COL2A1 protein CTD PMID:29660438 PMID:31299270 NCBI chr 7:129,098,489...129,127,620 JBrowse link
G Col3a1 collagen type III alpha 1 chain increases expression
multiple interactions
ISO Nicotine results in increased expression of COL3A1 mRNA
NGF protein affects the reaction [Nicotine results in increased expression of COL3A1 mRNA]
CTD PMID:33082140 NCBI chr 9:47,374,611...47,410,547 JBrowse link
G Col6a1 collagen type VI alpha 1 chain multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of COL6A1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of COL6A1 mRNA] CTD PMID:20230807 NCBI chr20:11,906,105...11,924,599 JBrowse link
G Cort cortistatin affects expression
decreases expression
EXP Nicotine affects the expression of CORT protein
Nicotine results in decreased expression of CORT protein
CTD PMID:22975262 PMID:26776438 PMID:28555334 NCBI chr 5:159,560,591...159,562,032 JBrowse link
G Cox7a2l cytochrome c oxidase subunit 7A2 like multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of COX7A2L mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of COX7A2L mRNA] CTD PMID:20230807 NCBI chr 6:11,184,284...11,198,287 JBrowse link
G Cox7c cytochrome c oxidase subunit 7C multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of COX7C mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of COX7C mRNA] CTD PMID:20230807 NCBI chr 2:16,841,771...16,843,796 JBrowse link
G Crabp2 cellular retinoic acid binding protein 2 decreases expression ISO Nicotine results in decreased expression of CRABP2 mRNA CTD PMID:16949557 NCBI chr 2:173,417,004...173,421,352 JBrowse link
G Crct1 cysteine-rich C-terminal 1 increases expression ISO Nicotine results in increased expression of CRCT1 mRNA CTD PMID:23825647
G Creb1 cAMP responsive element binding protein 1 multiple interactions
increases expression
increases phosphorylation
decreases expression
ISO
EXP
CREB1 protein promotes the reaction [Nicotine results in increased expression of MMP7 mRNA]
Nicotine results in increased expression of CREB1 mRNA
Nicotine results in increased phosphorylation of CREB1 protein
CREB1 protein promotes the reaction [Nicotine results in increased expression of RYR2 mRNA]; Excitatory Amino Acid Antagonists inhibits the reaction [Nicotine results in increased phosphorylation of CREB1 protein]; KN 93 inhibits the reaction [Nicotine results in increased phosphorylation of CREB1 protein]; Mecamylamine inhibits the reaction [Nicotine results in increased phosphorylation of CREB1 protein]; Nicotine promotes the reaction [CREB1 protein modified form binds to RYR2 promoter]; Nifedipine inhibits the reaction [Nicotine results in increased phosphorylation of CREB1 protein]; Ryanodine inhibits the reaction [Nicotine results in increased phosphorylation of CREB1 protein]
Nicotine results in decreased expression of CREB1 mRNA
CTD PMID:18247414 PMID:21113126 PMID:25847246 PMID:31945395 NCBI chr 9:65,903,511...65,972,562 JBrowse link
G Creb3 cAMP responsive element binding protein 3 increases expression ISO Nicotine results in increased expression of CREB3 mRNA CTD PMID:31945395 NCBI chr 5:57,817,835...57,823,171 JBrowse link
G Creb5 cAMP responsive element binding protein 5 increases expression ISO Nicotine results in increased expression of CREB5 mRNA CTD PMID:31945395 NCBI chr 4:82,393,091...82,794,320 JBrowse link
G Crebbp CREB binding protein increases expression ISO Nicotine results in increased expression of CREBBP mRNA CTD PMID:31945395 NCBI chr10:11,335,551...11,461,888 JBrowse link
G Crh corticotropin releasing hormone decreases expression
increases expression
EXP
ISO
Nicotine results in decreased expression of CRH mRNA; Nicotine results in decreased expression of CRH protein
Nicotine results in increased expression of CRH protein
CTD PMID:21955143 PMID:22265867 PMID:23623838 PMID:28555334 NCBI chr 2:102,143,055...102,144,919 JBrowse link
G Cryab crystallin, alpha B decreases expression ISO Nicotine results in decreased expression of CRYAB mRNA CTD PMID:21955143 NCBI chr 8:51,093,441...51,099,161 JBrowse link
G Cs citrate synthase multiple interactions ISO [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of CS mRNA CTD PMID:33091441 NCBI chr 7:758,074...791,421 JBrowse link
G Csdc2 cold shock domain containing C2 decreases expression ISO Nicotine results in decreased expression of CSDC2 mRNA CTD PMID:21955143 NCBI chr 7:113,451,998...113,466,464 JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions
increases secretion
ISO Nicotine results in increased expression of and results in increased secretion of CSF2 protein; Tubocurarine inhibits the reaction [Nicotine results in increased secretion of CSF2 protein] CTD PMID:9606035 PMID:18082304 NCBI chr10:38,386,945...38,388,926 JBrowse link
G Csn2 casein beta multiple interactions ISO Nicotine results in decreased expression of and results in decreased secretion of CSN2 protein CTD PMID:31783125 NCBI chr14:20,322,581...20,329,818 JBrowse link
G Cst3 cystatin C multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CST3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CST3 mRNA] CTD PMID:20230807 NCBI chr 3:136,336,923...136,340,796 JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
increases expression
ISO Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of CTNNB1 mRNA]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of CTNNB1 protein]
Nicotine results in increased expression of CTNNB1 mRNA; Nicotine results in increased expression of CTNNB1 protein
CTD PMID:33640489 NCBI chr 8:120,640,008...120,667,110 JBrowse link
G Ctsb cathepsin B multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CTSB mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CTSB mRNA] CTD PMID:20230807 NCBI chr15:37,389,636...37,410,508 JBrowse link
G Ctsh cathepsin H increases expression ISO Nicotine results in increased expression of CTSH mRNA CTD PMID:23825647 NCBI chr 8:90,608,941...90,627,824 JBrowse link
G Ctsl cathepsin L multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CTSL mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CTSL mRNA] CTD PMID:20230807 NCBI chr17:764,370...770,533 JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 decreases expression ISO Nicotine results in decreased expression of CXCL2 mRNA CTD PMID:18247414 NCBI chr14:17,181,030...17,183,075 JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 decreases expression
decreases secretion
increases expression
ISO Nicotine results in decreased expression of CXCL1 mRNA
Nicotine results in decreased secretion of CXCL1 protein
Nicotine results in increased expression of CXCL1 protein
CTD PMID:16254210 PMID:22093924 NCBI chr14:17,270,146...17,289,458 JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 decreases expression
increases expression
ISO Nicotine results in decreased expression of CXCR2 mRNA
Nicotine results in increased expression of CXCR2 mRNA
CTD PMID:18247414 PMID:20457658 NCBI chr 9:75,729,493...75,735,868 JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 increases expression ISO Nicotine results in increased expression of CXCR3 mRNA CTD PMID:20457658 NCBI chr  X:66,844,318...66,846,969 JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 multiple interactions
increases expression
ISO [Mecamylamine co-treated with Dihydro-beta-Erythroidine co-treated with Bungarotoxins] inhibits the reaction [Nicotine results in increased expression of CXCR4 protein]
Nicotine results in increased expression of CXCR4 mRNA; Nicotine results in increased expression of CXCR4 protein
CTD PMID:20457658 NCBI chr13:40,077,976...40,081,883 JBrowse link
G Cycs cytochrome c, somatic multiple interactions
increases expression
increases secretion
affects localization
decreases secretion
ISO
EXP
Nicotine inhibits the reaction [1-Methyl-4-phenylpyridinium affects the localization of CYCS protein]
Nicotine results in increased expression of CYCS protein
Nicotine results in increased secretion of CYCS protein
Folic Acid inhibits the reaction [Nicotine results in increased expression of CYCS protein]; Nicotine inhibits the reaction [[Calcium co-treated with Phosphates] affects the localization of CYCS protein]
Nicotine affects the localization of CYCS protein
Nicotine results in decreased secretion of CYCS protein
CTD PMID:11701223 PMID:15985439 PMID:18203686 PMID:29972271 NCBI chr 4:79,651,894...79,653,994 JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression
decreases activity
multiple interactions
ISO
EXP
Nicotine results in decreased expression of CYP11A1 mRNA; Nicotine results in decreased expression of CYP11A1 protein
Nicotine results in decreased activity of CYP11A1 protein
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CYP11A1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP11A1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP11A1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP11A1 protein]
CTD PMID:20230807 PMID:21971485 PMID:22265867 PMID:24709674 PMID:28986172 PMID:30959089 PMID:31846720 NCBI chr 8:58,422,807...58,434,342 JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 decreases expression EXP Nicotine results in decreased expression of CYP11B1 mRNA CTD PMID:24709674 NCBI chr 7:106,838,590...106,845,004 JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression ISO
EXP
Nicotine results in decreased expression of CYP17A1 mRNA
Nicotine results in decreased expression of CYP17A1 mRNA; Nicotine results in decreased expression of CYP17A1 protein
CTD PMID:24709674 PMID:27782041 PMID:28986172 NCBI chr 1:245,535,462...245,543,148 JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases expression
increases activity
multiple interactions
ISO
EXP
Nicotine results in decreased expression of CYP19A1 mRNA; Nicotine results in decreased expression of CYP19A1 protein
Nicotine results in increased activity of CYP19A1 protein
Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP19A1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP19A1 protein]
CTD PMID:30959089 PMID:32113805 NCBI chr 8:54,553,165...54,580,758 JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO Nicotine results in increased expression of CYP1A1 mRNA; Nicotine results in increased expression of CYP1A1 protein CTD PMID:11849738 PMID:22498344 NCBI chr 8:58,096,021...58,102,130 JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
decreases expression
decreases activity
ISO
EXP
Nicotine results in increased expression of CYP1A2 protein
Nicotine results in decreased expression of CYP1A2 mRNA
Nicotine results in decreased activity of CYP1A2 protein
CTD PMID:11849738 PMID:15916432 PMID:26463278 NCBI chr 8:58,075,367...58,082,255 JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 decreases expression ISO Nicotine results in decreased expression of CYP26A1 mRNA; Nicotine results in decreased expression of CYP26A1 protein CTD PMID:21371177 NCBI chr 1:235,471,368...235,475,204 JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 increases expression
decreases activity
increases metabolic processing
multiple interactions
EXP
ISO
Nicotine results in increased expression of CYP2A1 mRNA
Nicotine results in decreased activity of CYP2A13 protein
CYP2A13 protein results in increased metabolism of Nicotine
Nicotine inhibits the reaction [[CYP2A13 protein results in increased metabolism of N'-nitrosonornicotine] which results in increased abundance of 4-hydroxy-1-(3-pyridyl)-1-butanone]; Nicotine inhibits the reaction [CYP2A13 protein results in increased susceptibility to Aflatoxin B1]
CTD PMID:22743290 PMID:22934830 PMID:27567546 NCBI chr 1:82,231,611...82,244,887 JBrowse link
G Cyp2a2 cytochrome P450, family 2, subfamily a, polypeptide 2 increases expression EXP Nicotine results in increased expression of CYP2A2 mRNA CTD PMID:22934830 NCBI chr 1:82,263,833...82,289,487 JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 increases expression
multiple interactions
EXP
ISO
Nicotine results in increased expression of CYP2A3 mRNA
CYP2A5 protein results in increased metabolism of and affects the susceptibility to Nicotine
CTD PMID:14972772 PMID:16485141 PMID:22934830 NCBI chr 1:82,171,914...82,179,980 JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions
increases expression
increases metabolic processing
EXP [Nicotine co-treated with 2,2',3,5',6-pentachlorobiphenyl] results in increased expression of CYP2B1 mRNA; [Nicotine results in increased expression of CYP2B1 protein] which results in increased abundance of Cotinine; [Nicotine results in increased expression of CYP2B1 protein] which results in increased metabolism of Nicotine; Nicotine results in increased expression of and results in increased activity of CYP2B1 protein
Nicotine results in increased expression of CYP2B1 mRNA; Nicotine results in increased expression of CYP2B1 protein
CYP2B1 protein results in increased metabolism of Nicotine
CTD PMID:10799646 PMID:14972772 PMID:20599831 PMID:26463278 NCBI chr 1:81,518,387...81,544,999 JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases metabolic processing
increases oxidation
affects oxidation
multiple interactions
ISO CYP2B6 protein results in increased metabolism of Nicotine
CYP2B6 protein results in increased oxidation of Nicotine
CYP2B6 gene polymorphism affects the oxidation of Nicotine
CYP2B6 gene polymorphism affects the reaction [CYP2A6 protein results in increased metabolism of Nicotine]
CTD PMID:12488541 PMID:18004205 PMID:30906561 NCBI chr 1:81,652,762...81,732,153 JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions
increases expression
ISO Ketoconazole inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 mRNA]]; Ketoconazole inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 protein]]; Ketoconazole inhibits the reaction [Nicotine results in increased expression of CYP2D22 mRNA]; Ketoconazole inhibits the reaction [Nicotine results in increased expression of CYP2D22 protein]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 mRNA]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 protein]; Nicotine inhibits the reaction [Ketoconazole results in decreased expression of CYP2D22 mRNA]; Nicotine inhibits the reaction [Ketoconazole results in decreased expression of CYP2D22 protein]
Nicotine results in increased expression of CYP2D22 mRNA; Nicotine results in increased expression of CYP2D22 protein
CTD PMID:19594327 NCBI chr 7:113,882,584...113,891,754 JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression EXP Nicotine results in increased expression of CYP2E1 protein CTD PMID:16434548 NCBI chr 1:195,840,330...195,850,728 JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions EXP [Nicotine co-treated with 2,2',3,5',6-pentachlorobiphenyl] results in increased expression of CYP3A2 mRNA CTD PMID:26463278 NCBI chr12:9,207,986...9,230,038 JBrowse link
G Cyp4f18 cytochrome P450, family 4, subfamily f, polypeptide 18 increases expression ISO Nicotine results in increased expression of CYP4F3 mRNA CTD PMID:23825647 NCBI chr16:17,763,543...17,804,944 JBrowse link
G Dbh dopamine beta-hydroxylase multiple interactions
increases expression
ISO [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of DBH mRNA] CTD PMID:17498763 NCBI chr 3:10,488,260...10,505,245 JBrowse link
G Dcaf16 DDB1 and CUL4 associated factor 16 increases expression ISO Nicotine results in increased expression of DCAF16 mRNA CTD PMID:16949557 NCBI chr14:65,449,631...65,450,875 JBrowse link
G Ddb1 damage-specific DNA binding protein 1 decreases expression ISO Nicotine results in decreased expression of DDB1 mRNA CTD PMID:16949557 NCBI chr 1:207,252,890...207,278,685 JBrowse link
G Ddhd2 DDHD domain containing 2 multiple interactions ISO [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of DDHD2 mRNA CTD PMID:28065790 NCBI chr16:66,319,469...66,349,025 JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO
EXP
Nicotine inhibits the reaction [Cisplatin results in increased expression of DDIT3 mRNA]
Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DDIT3 protein]
Nicotine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of DDIT3 protein]
CTD PMID:11592233 PMID:28082123 NCBI chr 7:63,115,645...63,121,203 JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO Nicotine results in increased expression of DDIT4 mRNA CTD PMID:17456735 PMID:23825647 NCBI chr20:27,891,989...27,894,088 JBrowse link
G Ddx17 DEAD-box helicase 17 increases expression ISO Nicotine results in increased expression of DDX17 mRNA CTD PMID:16949557 NCBI chr 7:111,091,127...111,109,353 JBrowse link
G Ddx58 DEXD/H-box helicase 58 multiple interactions ISO Nicotine inhibits the reaction [Poly I-C results in increased expression of DDX58 mRNA] CTD PMID:31154625 NCBI chr 5:55,321,229...55,369,947 JBrowse link
G Dedd death effector domain-containing decreases expression ISO Nicotine results in decreased expression of DEDD mRNA CTD PMID:18247414 NCBI chr13:83,755,874...83,769,982 JBrowse link
G Defb23 defensin beta 23 decreases expression ISO Nicotine results in decreased expression of DEFB129 mRNA CTD PMID:23825647 NCBI chr 3:140,923,474...140,927,686 JBrowse link
G Dffb DNA fragmentation factor subunit beta decreases expression ISO Nicotine results in decreased expression of DFFB mRNA CTD PMID:18247414 NCBI chr 5:164,522,446...164,534,733 JBrowse link
G Dhcr24 24-dehydrocholesterol reductase decreases expression ISO Nicotine results in decreased expression of DHCR24 mRNA CTD PMID:21955143 NCBI chr 5:121,344,637...121,368,853 JBrowse link
G Dhfr dihydrofolate reductase multiple interactions
decreases expression
ISO alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of DHFR mRNA]; Mecamylamine inhibits the reaction [Nicotine results in decreased expression of DHFR mRNA]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of DHFR mRNA] CTD PMID:12588870 NCBI chr 2:23,585,876...23,611,199 JBrowse link
G Dhps deoxyhypusine synthase decreases expression ISO Nicotine results in decreased expression of DHPS mRNA CTD PMID:16949557 NCBI chr19:23,082,454...23,086,544 JBrowse link
G Dhrs3 dehydrogenase/reductase 3 increases expression ISO Nicotine results in increased expression of DHRS3 mRNA CTD PMID:23825647 NCBI chr 5:156,747,939...156,782,420 JBrowse link
G Dhx36 DEAH-box helicase 36 increases expression ISO Nicotine results in increased expression of DHX36 mRNA CTD PMID:17997037 NCBI chr 2:146,856,469...146,894,577 JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 decreases expression
decreases methylation
ISO
EXP
Nicotine results in decreased expression of DLG4 mRNA
Nicotine results in decreased methylation of DLG4 gene
CTD PMID:21955143 PMID:28555334 PMID:32994467 NCBI chr10:54,740,700...54,769,097 JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of DNAJA1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DNAJA1 mRNA] CTD PMID:20230807 NCBI chr 5:55,842,414...55,853,326 JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of DNAJB9 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DNAJB9 mRNA] CTD PMID:20230807 NCBI chr 6:61,270,385...61,276,795 JBrowse link
G Dnase2 deoxyribonuclease 2, lysosomal decreases expression ISO Nicotine results in decreased expression of DNASE2 mRNA CTD PMID:18247414 NCBI chr19:23,244,661...23,247,329 JBrowse link
G Dnm1l dynamin 1-like increases expression ISO Nicotine results in increased expression of DNM1L protein CTD PMID:21554491 NCBI chr11:84,581,216...84,632,382 JBrowse link
G Dnmt1 DNA methyltransferase 1 decreases expression
multiple interactions
EXP Nicotine results in decreased expression of DNMT1 mRNA
Dihydro-beta-Erythroidine analog inhibits the reaction [Nicotine results in decreased expression of DNMT1 mRNA]
CTD PMID:28555334 NCBI chr 8:19,440,611...19,486,659 JBrowse link
G Dpp4 dipeptidylpeptidase 4 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of DPP4 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DPP4 mRNA] CTD PMID:20230807 NCBI chr 3:46,962,243...47,043,870 JBrowse link
G Drd1 dopamine receptor D1 multiple interactions
decreases expression
EXP
ISO
[SCH 23390 binds to and results in decreased activity of DRD1 protein] which results in decreased susceptibility to Nicotine
Nicotine results in decreased expression of DRD1 mRNA
CTD PMID:1833784 PMID:21955143 NCBI chr17:10,540,440...10,544,971 JBrowse link
G Drd2 dopamine receptor D2 multiple interactions
decreases response to substance
EXP [Raclopride binds to and results in decreased activity of DRD2 protein] which results in decreased susceptibility to Nicotine
DRD2 mRNA results in decreased susceptibility to Nicotine
CTD PMID:1833784 PMID:24239691 NCBI chr 8:49,708,903...49,772,888 JBrowse link
G Drd3 dopamine receptor D3 increases expression ISO Nicotine results in increased expression of DRD3 protein CTD PMID:31945395 NCBI chr11:56,879,689...56,931,901 JBrowse link
G Dtymk deoxythymidylate kinase decreases expression ISO Nicotine results in decreased expression of DTYMK mRNA CTD PMID:16949557 NCBI chr 9:94,315,552...94,324,386 JBrowse link
G Dusp1 dual specificity phosphatase 1 increases expression ISO Nicotine results in increased expression of DUSP1 mRNA CTD PMID:17456735 NCBI chr10:16,680,489...16,683,276 JBrowse link
G Dusp11 dual specificity phosphatase 11 decreases expression ISO Nicotine results in decreased expression of DUSP11 mRNA CTD PMID:17456735 NCBI chr 4:118,367,673...118,385,183 JBrowse link
G Dusp6 dual specificity phosphatase 6 increases expression ISO Nicotine results in increased expression of DUSP6 mRNA CTD PMID:17456735 PMID:21955143 NCBI chr 7:34,092,848...34,097,186 JBrowse link
G Dvl2 dishevelled segment polarity protein 2 decreases expression
increases expression
multiple interactions
ISO Nicotine results in decreased expression of DVL2 mRNA
Nicotine results in increased expression of DVL2 mRNA; Nicotine results in increased expression of DVL2 protein
Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of DVL2 mRNA]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of DVL2 protein]
CTD PMID:16949557 PMID:33640489 NCBI chr10:54,723,356...54,732,823 JBrowse link
G Dync1li2 dynein, cytoplasmic 1 light intermediate chain 2 increases expression ISO Nicotine results in increased expression of DYNC1LI2 mRNA CTD PMID:16949557 NCBI chr19:531,783...554,670 JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions
increases expression
ISO MK-886 inhibits the reaction [Nicotine results in increased expression of E2F1 protein]; Nicotine promotes the reaction [E2F1 protein binds to BIRC5 promoter]; Nicotine promotes the reaction [E2F1 protein binds to CDC25A promoter]; Nicotine promotes the reaction [E2F1 protein binds to CDC6 promoter] CTD PMID:16601104 PMID:16862215 PMID:20061081 NCBI chr 3:143,064,535...143,075,362 JBrowse link
G E2f2 E2F transcription factor 2 multiple interactions ISO Nicotine promotes the reaction [E2F2 protein binds to CDC25A promoter]; Nicotine promotes the reaction [E2F2 protein binds to CDC6 promoter] CTD PMID:16862215 NCBI chr 5:148,399,193...148,422,595 JBrowse link
G E2f3 E2F transcription factor 3 multiple interactions ISO Nicotine promotes the reaction [E2F3 protein binds to CDC25A promoter]; Nicotine promotes the reaction [E2F3 protein binds to CDC6 promoter] CTD PMID:16862215 NCBI chr17:34,601,756...34,679,139 JBrowse link
G E2f4 E2F transcription factor 4 multiple interactions ISO Nicotine inhibits the reaction [E2F4 protein binds to CDC25A promoter]; Nicotine inhibits the reaction [E2F4 protein binds to CDC6 promoter] CTD PMID:16862215 NCBI chr19:33,174,396...33,181,806 JBrowse link
G E2f5 E2F transcription factor 5 multiple interactions ISO Nicotine inhibits the reaction [E2F5 protein binds to CDC25A promoter]; Nicotine inhibits the reaction [E2F5 protein binds to CDC6 promoter] CTD PMID:16862215 NCBI chr 2:86,997,331...87,012,901 JBrowse link
G Ecm1 extracellular matrix protein 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ECM1 mRNA; Nicotine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ECM1 mRNA] CTD PMID:20230807 NCBI chr 2:183,287,491...183,292,729 JBrowse link
G Edn1 endothelin 1 multiple interactions
increases expression
ISO MIR98 mRNA inhibits the reaction [Nicotine results in increased expression of EDN1 mRNA]; NGF protein affects the reaction [Nicotine results in increased expression of EDN1 mRNA]; Rosiglitazone inhibits the reaction [Nicotine results in increased expression of EDN1 mRNA]
Nicotine results in increased expression of EDN1 mRNA; Nicotine results in increased expression of EDN1 protein
CTD PMID:33082140 NCBI chr17:22,454,924...22,460,812 JBrowse link
G Ednra endothelin receptor type A decreases expression ISO Nicotine results in decreased expression of EDNRA mRNA CTD PMID:18247414 NCBI chr19:30,233,540...30,303,727 JBrowse link
G Ednrb endothelin receptor type B increases activity EXP Nicotine results in increased activity of EDNRB protein CTD PMID:21316381 NCBI chr15:80,640,839...80,672,115 JBrowse link
G Eef2 eukaryotic translation elongation factor 2 increases expression
multiple interactions
ISO Nicotine results in increased expression of EEF2 protein modified form
[Nicotine results in increased expression of UBA2 protein] which results in increased sumoylation of EEF2 protein
CTD PMID:21554491 NCBI chr 7:8,533,248...8,538,518 JBrowse link
G Efhd1 EF-hand domain family, member D1 decreases expression ISO Nicotine results in decreased expression of EFHD1 mRNA CTD PMID:21955143 NCBI chr 9:87,938,259...87,984,917 JBrowse link
G Efna2 ephrin A2 increases expression ISO Nicotine results in increased expression of EFNA2 mRNA CTD PMID:23825647 NCBI chr 7:9,515,635...9,528,071 JBrowse link
G Efnb3 ephrin B3 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of EFNB3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of EFNB3 mRNA] CTD PMID:20230807 NCBI chr10:54,274,506...54,281,951 JBrowse link
G Egfr epidermal growth factor receptor decreases expression
increases phosphorylation
multiple interactions
EXP
ISO
Nicotine results in decreased expression of EGFR mRNA
Nicotine results in increased phosphorylation of EGFR protein
AG 1879 inhibits the reaction [Nicotine results in increased phosphorylation of EGFR protein]
CTD PMID:11478936 PMID:14569062 NCBI chr14:91,176,931...91,349,722 JBrowse link
G Egr1 early growth response 1 increases expression
decreases expression
multiple interactions
ISO
EXP
Nicotine results in increased expression of EGR1 mRNA; Nicotine results in increased expression of EGR1 protein
Nicotine results in decreased expression of EGR1 mRNA
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of EGR1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EGR1 mRNA]
[triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine promotes the reaction [EGR1 protein binds to FGF2 promoter]]] which results in decreased expression of FGF2 mRNA; EGR1 protein inhibits the reaction [triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine results in increased secretion of FGF2 protein]]; EGR1 protein promotes the reaction [Nicotine results in decreased expression of HSD11B2 mRNA]; EGR1 protein promotes the reaction [Nicotine results in decreased expression of HSD11B2 protein]; Nicotine promotes the reaction [EGR1 protein binds to FGF2 promoter]; triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine promotes the reaction [EGR1 protein binds to FGF2 promoter]]; triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine results in increased expression of EGR1 protein]; Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of EGR1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of EGR1 protein]
CTD PMID:17456735 PMID:17997037 PMID:20230807 PMID:21955143 PMID:22198237 PMID:29486207 PMID:31622651 NCBI chr18:26,463,333...26,465,531 JBrowse link
G Egr2 early growth response 2 increases expression ISO Nicotine results in increased expression of EGR2 mRNA CTD PMID:17456735 NCBI chr20:21,051,270...21,056,322 JBrowse link
G Egr3 early growth response 3 decreases expression ISO Nicotine results in decreased expression of EGR3 mRNA CTD PMID:21955143 NCBI chr15:45,150,335...45,156,052 JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 increases expression ISO Nicotine results in increased expression of EIF2AK2 mRNA CTD PMID:16949557 NCBI chr 6:16,189,000...16,224,972 JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions
increases phosphorylation
EXP Mecamylamine inhibits the reaction [Nicotine results in increased phosphorylation of EIF2AK3 protein]; ursodoxicoltaurine inhibits the reaction [Nicotine results in increased phosphorylation of EIF2AK3 protein] CTD PMID:26803847 NCBI chr 4:102,805,495...102,866,914 JBrowse link
G Eif2b4 eukaryotic translation initiation factor 2B subunit delta multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of EIF2B4 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EIF2B4 mRNA] CTD PMID:20230807 NCBI chr 6:25,183,177...25,188,832 JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation EXP Nicotine results in increased phosphorylation of EIF2S1 protein CTD PMID:26803847 NCBI chr 6:97,672,829...97,697,499 JBrowse link
G Eif4e eukaryotic translation initiation factor 4E multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of EIF4E mRNA; Nicotine affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EIF4E mRNA]
EIF4E protein affects the reaction [Nicotine results in increased expression of BCL2 protein]; EIF4E protein affects the reaction [Nicotine results in increased expression of CCND1 protein]; EIF4E protein affects the reaction [Nicotine results in increased expression of MYC protein]; EIF4E protein affects the reaction [Nicotine results in increased expression of VEGFA protein]; Nicotine promotes the reaction [EIF4EBP1 protein binds to EIF4E protein]
CTD PMID:20230807 PMID:30836163 NCBI chr 2:227,066,519...227,099,261 JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of EIF4EBP1 protein; Nicotine promotes the reaction [EIF4EBP1 protein binds to EIF4E protein]; Nicotine results in increased expression of and results in increased phosphorylation of EIF4EBP1 protein CTD PMID:12511591 PMID:30836163 NCBI chr16:64,792,595...64,805,984 JBrowse link
G Eif5 eukaryotic translation initiation factor 5 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of EIF5 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of EIF5 mRNA] CTD PMID:20230807
G Elk1 ETS transcription factor ELK1 increases phosphorylation
multiple interactions
EXP
ISO
Nicotine results in increased phosphorylation of ELK1 protein
Vecuronium Bromide inhibits the reaction [Nicotine results in increased phosphorylation of ELK1 protein]
CTD PMID:29486207 NCBI chr  X:1,138,826...1,155,713 JBrowse link
G Emc3 ER membrane protein complex subunit 3 decreases expression ISO Nicotine results in decreased expression of EMC3 mRNA CTD PMID:17997037 NCBI chr 4:146,663,065...146,678,976 JBrowse link
G Emcn endomucin increases expression ISO Nicotine results in increased expression of EMCN mRNA CTD PMID:17456735 NCBI chr 2:225,891,100...225,970,932 JBrowse link
G Eml4 EMAP like 4 multiple interactions
decreases expression
ISO alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of EML4 mRNA]; Mecamylamine promotes the reaction [Nicotine results in decreased expression of EML4 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of EML4 mRNA] CTD PMID:12588870 NCBI chr 6:11,219,545...11,334,824 JBrowse link
G Emp1 epithelial membrane protein 1 increases expression ISO Nicotine results in increased expression of EMP1 mRNA CTD PMID:23825647 NCBI chr 4:168,212,901...168,233,039 JBrowse link
G Enc1 ectodermal-neural cortex 1 decreases expression ISO Nicotine results in decreased expression of ENC1 mRNA CTD PMID:17997037 NCBI chr 2:28,550,670...28,562,591 JBrowse link
G Eng endoglin decreases expression ISO Nicotine results in decreased expression of ENG mRNA CTD PMID:17456735 NCBI chr 3:15,934,566...15,972,618 JBrowse link
G Eno1 enolase 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ENO1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ENO1 mRNA] CTD PMID:20230807 NCBI chr 5:160,719,951...160,731,337 JBrowse link
G Entpd3 ectonucleoside triphosphate diphosphohydrolase 3 increases expression ISO Nicotine results in increased expression of ENTPD3 mRNA CTD PMID:23825647 NCBI chr 8:120,246,412...120,277,943 JBrowse link
G Epha3 Eph receptor A3 decreases expression ISO Nicotine results in decreased expression of EPHA3 mRNA CTD PMID:18247414 NCBI chr11:1,138,485...1,474,102 JBrowse link
G Ephb3 Eph receptor B3 decreases expression ISO Nicotine results in decreased expression of EPHB3 mRNA CTD PMID:18247414 NCBI chr11:79,840,668...79,859,467 JBrowse link
G Epo erythropoietin increases expression ISO Nicotine results in increased expression of EPO mRNA CTD PMID:18247414 NCBI chr12:19,204,258...19,207,948 JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ERN1 mRNA; Nicotine affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ERN1 mRNA] CTD PMID:20230807 NCBI chr10:91,326,889...91,421,201 JBrowse link
G Erp44 endoplasmic reticulum protein 44 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ERP44 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ERP44 mRNA] CTD PMID:20230807 NCBI chr 5:62,516,550...62,610,762 JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 increases expression ISO Nicotine results in increased expression of ERRFI1 mRNA CTD PMID:17456735 NCBI chr 5:161,323,981...161,337,289 JBrowse link
G Etfa electron transfer flavoprotein subunit alpha multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ETFA mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ETFA mRNA] CTD PMID:20230807 NCBI chr 8:55,835,115...55,891,890 JBrowse link
G Etfb electron transfer flavoprotein subunit beta decreases expression ISO Nicotine results in decreased expression of ETFB mRNA CTD PMID:17997037 NCBI chr 1:93,851,908...93,866,072 JBrowse link
G Ezr ezrin multiple interactions
increases expression
ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of EZR mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EZR mRNA]
Nicotine results in increased expression of EZR mRNA
CTD PMID:18247414 PMID:20230807 NCBI chr 1:46,967,961...47,011,505 JBrowse link
G F2 coagulation factor II increases expression ISO Nicotine results in increased expression of F2 mRNA CTD PMID:18805435 NCBI chr 3:77,596,196...77,609,486 JBrowse link
G F2rl2 coagulation factor II (thrombin) receptor-like 2 increases expression EXP Nicotine results in increased expression of F2RL2 mRNA CTD PMID:27782041 NCBI chr 2:26,972,054...26,977,098 JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO Nicotine results in increased expression of F3 mRNA CTD PMID:17997037 NCBI chr 2:209,827,061...209,838,666 JBrowse link
G Fah fumarylacetoacetate hydrolase increases expression ISO Nicotine results in increased expression of FAH mRNA CTD PMID:23825647 NCBI chr 1:138,548,830...138,571,599 JBrowse link
G Fam107a family with sequence similarity 107, member A decreases expression ISO Nicotine results in decreased expression of FAM107A mRNA CTD PMID:21955143 NCBI chr15:16,608,362...16,630,398 JBrowse link
G Fam120a family with sequence similarity 120A decreases expression ISO Nicotine results in decreased expression of FAM120A mRNA CTD PMID:17997037 NCBI chr17:15,684,233...15,774,964 JBrowse link
G Fam83f family with sequence similarity 83, member F increases expression ISO Nicotine results in increased expression of FAM83F mRNA CTD PMID:23825647 NCBI chr 7:112,211,164...112,240,454 JBrowse link
G Fas Fas cell surface death receptor increases expression ISO
EXP
Nicotine results in increased expression of FAS mRNA; Nicotine results in increased expression of FAS protein CTD PMID:18203686 PMID:20383341 NCBI chr 1:231,798,963...231,832,591 JBrowse link
G Faslg Fas ligand affects expression
increases expression
EXP
ISO
Nicotine affects the expression of FASLG mRNA
Nicotine results in increased expression of FASLG mRNA; Nicotine results in increased expression of FASLG protein
Nicotine results in increased expression of FASLG protein alternative form
CTD PMID:18203686 PMID:18247414 PMID:19896492 PMID:20383341 PMID:20426880 NCBI chr13:74,151,519...74,172,760 JBrowse link
G Fasn fatty acid synthase increases expression
affects expression
multiple interactions
EXP
ISO
Nicotine results in increased expression of FASN mRNA; Nicotine results in increased expression of FASN protein
Nicotine affects the expression of FASN mRNA
Nicotine promotes the reaction [NR1H3 protein binds to FASN promoter]
CTD PMID:24368177 PMID:29155039 PMID:31622651 PMID:31972234 NCBI chr10:106,072,093...106,090,259 JBrowse link
G Fat1 FAT atypical cadherin 1 increases expression ISO Nicotine results in increased expression of FAT1 mRNA CTD PMID:16949557 NCBI chr16:47,177,253...47,296,261 JBrowse link
G Fat2 FAT atypical cadherin 2 increases expression ISO Nicotine results in increased expression of FAT2 mRNA CTD PMID:23825647 NCBI chr10:39,364,072...39,456,324 JBrowse link
G Fbn1 fibrillin 1 increases expression ISO Nicotine results in increased expression of FBN1 mRNA CTD PMID:17456735 NCBI chr 3:112,554,257...112,750,835 JBrowse link
G Fbxl12 F-box and leucine-rich repeat protein 12 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of FBXL12 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of FBXL12 mRNA] CTD PMID:20230807 NCBI chr 8:19,175,864...19,183,373 JBrowse link
G Fbxw5 F-box and WD repeat domain containing 5 decreases expression ISO Nicotine results in decreased expression of FBXW5 mRNA CTD PMID:17997037 NCBI chr 3:8,322,543...8,327,092 JBrowse link
G Fez1 fasciculation and elongation protein zeta 1 increases expression
multiple interactions
decreases expression
ISO Nicotine results in increased expression of FEZ1 mRNA
alpha-cobratoxin promotes the reaction [Nicotine results in decreased expression of FEZ1 mRNA alternative form]; Tubocurarine promotes the reaction [Nicotine results in decreased expression of FEZ1 mRNA]
CTD PMID:12588870 NCBI chr 8:36,544,462...36,589,684 JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions
increases expression
decreases expression
increases secretion
ISO
EXP
[triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine promotes the reaction [EGR1 protein binds to FGF2 promoter]]] which results in decreased expression of FGF2 mRNA; EGR1 protein inhibits the reaction [triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine results in increased secretion of FGF2 protein]]; Nicotine promotes the reaction [EGR1 protein binds to FGF2 promoter]; triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine promotes the reaction [EGR1 protein binds to FGF2 promoter]]; triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine results in increased secretion of FGF2 protein]
Nicotine results in increased expression of FGF2 mRNA; Nicotine results in increased expression of FGF2 protein
Mecamylamine inhibits the reaction [Nicotine results in increased expression of FGF2 mRNA]; triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine results in increased expression of FGF2 mRNA]
Nicotine results in decreased expression of FGF2 protein
CTD PMID:9503263 PMID:9832142 PMID:14732461 PMID:15465631 PMID:16365874 PMID:18190895 PMID:22198237 PMID:31622651 PMID:32512034 NCBI chr 2:120,236,328...120,290,673 JBrowse link
G Flrt2 fibronectin leucine rich transmembrane protein 2 increases expression ISO Nicotine results in increased expression of FLRT2 mRNA CTD PMID:23825647 NCBI chr 6:114,777,547...114,872,688 JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 decreases expression ISO Nicotine results in decreased expression of FLT3 mRNA CTD PMID:18247414 NCBI chr12:7,623,658...7,699,474 JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 increases metabolic processing ISO FMO3 protein results in increased metabolism of Nicotine CTD PMID:12504349 NCBI chr13:75,309,367...75,334,915 JBrowse link
G Fn1 fibronectin 1 decreases expression
increases expression
multiple interactions
ISO Nicotine results in decreased expression of FN1 mRNA
Nicotine results in increased expression of FN1 mRNA; Nicotine results in increased expression of FN1 protein
MIR98 mRNA inhibits the reaction [Nicotine results in increased expression of FN1 mRNA]; NGF protein affects the reaction [Nicotine results in increased expression of FN1 mRNA]; Rosiglitazone inhibits the reaction [Nicotine results in increased expression of FN1 mRNA]
CTD PMID:18247414 PMID:18844224 PMID:33082140 NCBI chr 9:73,196,044...73,264,695 JBrowse link
G Folr1 folate receptor alpha increases expression ISO Nicotine results in increased expression of FOLR1 mRNA CTD PMID:19616087 NCBI chr 1:156,219,460...156,238,436 JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
affects expression
multiple interactions
decreases expression
ISO
EXP
Nicotine results in increased expression of FOS; Nicotine results in increased expression of FOS mRNA; Nicotine results in increased expression of FOS protein
Nicotine deficiency affects the expression of FOS protein
Acetaldehyde promotes the reaction [Nicotine results in increased expression of FOS mRNA]; Saponins inhibits the reaction [Nicotine results in increased expression of FOS protein]
Nicotine results in decreased expression of FOS mRNA
[U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of FOS protein]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of FOS]
CTD PMID:11425648 PMID:15857624 PMID:16251992 PMID:16690037 PMID:17003101 PMID:17151781 PMID:17287824 PMID:17456735 PMID:20426880 PMID:27126842 NCBI chr 6:105,121,170...105,124,036 JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit increases expression ISO
EXP
Nicotine results in increased expression of FOSB mRNA
Nicotine results in increased expression of FOSB protein
CTD PMID:16949557 PMID:17324382 PMID:17456735 NCBI chr 1:78,954,312...78,961,492 JBrowse link
G Foxo1 forkhead box O1 multiple interactions ISO [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of FOXO1 protein CTD PMID:12511591 NCBI chr 2:136,312,168...136,390,603 JBrowse link
G Foxp1 forkhead box P1 decreases expression ISO Nicotine results in decreased expression of FOXP1 mRNA CTD PMID:21955143 NCBI chr 4:131,559,599...132,155,092 JBrowse link
G Foxp3 forkhead box P3 decreases expression ISO Nicotine results in decreased expression of FOXP3 protein CTD PMID:31629012 NCBI chr  X:14,908,494...14,924,994 JBrowse link
G Fscn1 fascin actin-bundling protein 1 decreases expression ISO Nicotine results in decreased expression of SNL mRNA CTD PMID:18247414 NCBI chr12:11,597,042...11,610,183 JBrowse link
G Fshb follicle stimulating hormone subunit beta decreases expression EXP Nicotine results in decreased expression of FSHB mRNA; Nicotine results in decreased expression of FSHB protein CTD PMID:20498001 PMID:28986172 NCBI chr 3:93,548,560...93,552,370 JBrowse link
G Fxyd1 FXYD domain-containing ion transport regulator 1 increases expression ISO Nicotine results in increased expression of FXYD1 mRNA CTD PMID:17997037 NCBI chr 1:86,287,163...86,291,478 JBrowse link
G Fxyd7 FXYD domain-containing ion transport regulator 7 decreases expression ISO Nicotine results in decreased expression of FXYD7 mRNA CTD PMID:21955143 NCBI chr 1:86,277,678...86,286,954 JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase multiple interactions ISO LCK protein promotes the reaction [Nicotine results in increased phosphorylation of and results in increased activity of FYN protein]; Nicotine results in increased phosphorylation of and results in increased activity of FYN protein CTD PMID:17709503 NCBI chr20:42,767,733...42,960,903 JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases activity EXP Nicotine results in decreased activity of G6PD protein CTD PMID:20498001 NCBI chr  X:152,201,081...152,220,863 JBrowse link
G Gab1 GRB2-associated binding protein 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of GAB1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GAB1 mRNA] CTD PMID:20230807 NCBI chr19:27,131,262...27,239,236 JBrowse link
G Gabra3 gamma-aminobutyric acid type A receptor subunit alpha 3 increases expression EXP Nicotine results in increased expression of GABRA3 mRNA CTD PMID:28339662 NCBI chr  X:150,244,745...150,501,566 JBrowse link
G Gabra5 gamma-aminobutyric acid type A receptor subunit alpha 5 increases expression EXP Nicotine results in increased expression of GABRA5 mRNA CTD PMID:28339662 NCBI chr 1:108,268,728...108,381,670 JBrowse link
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 increases expression EXP Nicotine results in increased expression of GABRA6 mRNA CTD PMID:28339662 NCBI chr10:26,810,411...26,825,768 JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 increases expression ISO Nicotine results in increased expression of GABRG2 mRNA CTD PMID:21955143 NCBI chr10:26,376,805...26,463,680 JBrowse link
G Gad1 glutamate decarboxylase 1 increases expression
multiple interactions
decreases methylation
EXP Nicotine results in increased expression of GAD1 mRNA; Nicotine results in increased expression of GAD1 protein
Dihydro-beta-Erythroidine analog inhibits the reaction [Nicotine results in increased expression of GAD1 mRNA]
Nicotine results in decreased methylation of GAD1 promoter
CTD PMID:18312583 PMID:28555334 NCBI chr 3:55,369,704...55,410,335 JBrowse link
G Gad2 glutamate decarboxylase 2 decreases expression EXP Nicotine results in decreased expression of GAD2 mRNA CTD PMID:28555334 NCBI chr17:84,763,630...84,826,155 JBrowse link
G Gal galanin and GMAP prepropeptide decreases expression ISO Nicotine results in decreased expression of GAL mRNA CTD PMID:21955143 NCBI chr 1:200,650,439...200,655,302 JBrowse link
G Gale UDP-galactose-4-epimerase decreases expression ISO Nicotine results in decreased expression of GALE mRNA CTD PMID:16949557 NCBI chr 5:148,193,886...148,198,392 JBrowse link
G Galk2 galactokinase 2 increases expression ISO Nicotine results in increased expression of GALK2 mRNA CTD PMID:17456735 NCBI chr 3:113,110,057...113,243,014 JBrowse link
G Gap43 growth associated protein 43 multiple interactions ISO [Nicotine co-treated with polylactic acid-polyglycolic acid copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GAP43 mRNA]; [Nicotine co-treated with polylactic acid-polyglycolic acid copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GAP43 protein]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GAP43 mRNA]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GAP43 protein] CTD PMID:23933227 NCBI chr11:58,376,371...58,470,047 JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of GAPDH mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GAPDH mRNA] CTD PMID:20230807 NCBI chr 4:157,962,312...157,967,158 JBrowse link
G Gata2 GATA binding protein 2 multiple interactions
increases expression
ISO 5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Nicotine results in increased expression of GATA2 mRNA]; 5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Nicotine results in increased expression of GATA2 protein]; Bungarotoxins inhibits the reaction [Nicotine results in increased expression of GATA2 mRNA]; Bungarotoxins inhibits the reaction [Nicotine results in increased expression of GATA2 protein]; CHRNA7 protein affects the reaction [Nicotine results in increased expression of GATA2 mRNA]; CHRNA7 protein affects the reaction [Nicotine results in increased expression of GATA2 protein]; GATA2 protein affects the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; GATA2 protein affects the reaction [Nicotine results in increased expression of CHRNA7 protein]; manumycin inhibits the reaction [Nicotine results in increased expression of GATA2 mRNA]; manumycin inhibits the reaction [Nicotine results in increased expression of GATA2 protein]; U 0126 inhibits the reaction [Nicotine results in increased expression of GATA2 mRNA]; U 0126 inhibits the reaction [Nicotine results in increased expression of GATA2 protein]
Nicotine results in increased expression of GATA2 mRNA; Nicotine results in increased expression of GATA2 protein
CTD PMID:18450646 NCBI chr 4:120,654,205...120,667,763 JBrowse link
G Gata4 GATA binding protein 4 multiple interactions ISO [GATA4 co-treated with GATA6] affects the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; Nicotine promotes the reaction [[GATA4 protein binds to SP1 protein] which binds to CHRNA7 protein]; Nicotine promotes the reaction [GATA4 protein binds to SP1 protein]; Nicotine promotes the reaction [GATA6 protein binds to GATA4 protein binds to SP1 protein binds to CHRNA7 promoter] CTD PMID:24089524 NCBI chr15:37,459,601...37,531,291 JBrowse link
G Gata6 GATA binding protein 6 multiple interactions ISO [GATA4 co-treated with GATA6] affects the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; Nicotine promotes the reaction [[GATA6 protein binds to SP1 protein] which binds to CHRNA7 protein]; Nicotine promotes the reaction [GATA6 protein binds to GATA4 protein binds to SP1 protein binds to CHRNA7 promoter]; Nicotine promotes the reaction [GATA6 protein binds to SP1 protein]
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GATA6 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GATA6 mRNA]
CTD PMID:20230807 PMID:24089524 NCBI chr18:2,188,121...2,219,532 JBrowse link
G Gatad2b GATA zinc finger domain containing 2B increases expression ISO Nicotine results in increased expression of GATAD2B mRNA CTD PMID:33640489 NCBI chr 2:175,748,594...175,829,837 JBrowse link
G Gch1 GTP cyclohydrolase 1 increases expression ISO Nicotine results in increased expression of GCH1 mRNA CTD PMID:16949557 NCBI chr15:20,404,267...20,437,727 JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of GCLC mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GCLC mRNA] CTD PMID:20230807 NCBI chr 8:78,629,899...78,668,547 JBrowse link
G Gcm1 glial cells missing transcription factor 1 decreases expression EXP Nicotine results in decreased expression of GCM1 mRNA; Nicotine results in decreased expression of GCM1 protein CTD PMID:24368670 NCBI chr 8:78,925,687...78,938,924 JBrowse link
G Gcnt2 glucosaminyl (N-acetyl) transferase 2 (I blood group) increases expression
decreases expression
ISO Nicotine results in increased expression of GCNT2 mRNA
Nicotine results in decreased expression of GCNT2 mRNA
CTD PMID:17997037 PMID:21955143 NCBI chr17:23,796,859...23,901,625 JBrowse link
G Gdf1 growth differentiation factor 1 increases expression ISO Nicotine results in increased expression of GDF1 mRNA CTD PMID:18247414 NCBI chr16:19,097,309...19,112,519 JBrowse link
G Gem GTP binding protein overexpressed in skeletal muscle increases expression ISO Nicotine results in increased expression of GEM mRNA CTD PMID:17456735 NCBI chr 5:25,214,309...25,225,222 JBrowse link
G Gfap glial fibrillary acidic protein decreases expression
increases expression
ISO Nicotine results in decreased expression of GFAP mRNA
Nicotine results in increased expression of GFAP mRNA
CTD PMID:17997037 PMID:21955143 NCBI chr10:87,852,891...87,861,631 JBrowse link
G Ggct gamma-glutamyl cyclotransferase increases splicing ISO Nicotine results in increased splicing of GGCT mRNA alternative form CTD PMID:23825647 NCBI chr 4:84,122,921...84,129,327 JBrowse link
G Ggt1 gamma-glutamyltransferase 1 increases activity
multiple interactions
EXP Nicotine results in increased activity of GGT1 protein
Sodium Acetate inhibits the reaction [Nicotine results in increased activity of GGT1 protein]
CTD PMID:31857090 NCBI chr20:13,074,695...13,104,095 JBrowse link
G Ghitm growth hormone inducible transmembrane protein multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GHITM mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GHITM mRNA] CTD PMID:20230807 NCBI chr16:12,885,551...12,897,887 JBrowse link
G Gja4 gap junction protein, alpha 4 increases expression EXP Nicotine results in increased expression of GJA4 mRNA CTD PMID:28087314 NCBI chr 5:139,633,324...139,635,857 JBrowse link
G Gjc2 gap junction protein, gamma 2 increases expression ISO Nicotine results in increased expression of GJC2 mRNA CTD PMID:21955143 NCBI chr10:43,962,642...43,971,358 JBrowse link
G Glipr1 GLI pathogenesis-related 1 increases expression ISO Nicotine results in increased expression of GLIPR1 mRNA CTD PMID:16949557 NCBI chr 7:47,487,342...47,498,974 JBrowse link
G Gm2a GM2 ganglioside activator increases expression
increases splicing
ISO Nicotine results in increased expression of GM2A mRNA
Nicotine results in increased splicing of GM2A mRNA alternative form
CTD PMID:23825647 NCBI chr10:39,219,221...39,231,756 JBrowse link
G Gmfb glia maturation factor, beta multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GMFB mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GMFB mRNA] CTD PMID:20230807 NCBI chr15:20,069,923...20,081,005 JBrowse link
G Gnai2 G protein subunit alpha i2 increases splicing
multiple interactions
ISO Nicotine results in increased splicing of GNAI2 mRNA alternative form
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of GNAI2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GNAI2 mRNA]
CTD PMID:20230807 PMID:23825647 NCBI chr 8:108,288,401...108,309,009 JBrowse link
G Gng10 G protein subunit gamma 10 increases expression ISO Nicotine results in increased expression of GNG10 mRNA CTD PMID:16949557 NCBI chr 5:73,856,124...73,863,017 JBrowse link
G Gng11 G protein subunit gamma 11 decreases expression ISO Nicotine results in decreased expression of GNG11 mRNA CTD PMID:21955143 NCBI chr 4:32,023,003...32,028,443 JBrowse link
G Gnrhr gonadotropin releasing hormone receptor decreases expression EXP Nicotine results in decreased expression of GNRHR mRNA CTD PMID:28986172 NCBI chr14:21,856,871...21,874,861 JBrowse link
G Golga4 golgin A4 multiple interactions
increases expression
ISO alpha-cobratoxin inhibits the reaction [Nicotine results in increased expression of GOLGA4 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of GOLGA4 mRNA] CTD PMID:16949557 NCBI chr 8:118,208,200...118,285,003 JBrowse link
G Golt1b golgi transport 1B multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GOLT1B mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GOLT1B mRNA] CTD PMID:20230807 NCBI chr 4:175,333,056...175,346,156 JBrowse link
G Gosr2 golgi SNAP receptor complex member 2 multiple interactions ISO [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of GOSR2 mRNA CTD PMID:28065790 NCBI chr10:88,585,291...88,605,642 JBrowse link
G Gpatch2 G patch domain containing 2 increases splicing ISO Nicotine results in increased splicing of GPATCH2 mRNA alternative form CTD PMID:23825647 NCBI chr13:98,784,969...98,925,696 JBrowse link
G Gpnmb glycoprotein nmb increases expression ISO Nicotine results in increased expression of GPNMB mRNA CTD PMID:23825647 NCBI chr 4:78,010,247...78,031,491 JBrowse link
G Gpr50 G protein-coupled receptor 50 increases expression
increases splicing
ISO Nicotine results in increased expression of GPR50 mRNA
Nicotine results in increased splicing of GPR50 mRNA alternative form
CTD PMID:23825647 NCBI chr  X:149,368,900...149,373,486 JBrowse link
G Gpr6 G protein-coupled receptor 6 increases expression ISO Nicotine results in increased expression of GPR6 mRNA CTD PMID:21955143 NCBI chr20:44,489,853...44,492,624 JBrowse link
G Gpr83 G protein-coupled receptor 83 increases expression EXP Nicotine results in increased expression of GPR83 mRNA CTD PMID:27782041 NCBI chr 8:11,693,540...11,704,028 JBrowse link
G Gpr88 G-protein coupled receptor 88 increases expression ISO Nicotine results in increased expression of GPR88 mRNA CTD PMID:21955143 NCBI chr 2:204,191,443...204,199,576 JBrowse link
G Gprasp1 G protein-coupled receptor associated sorting protein 1 increases expression ISO Nicotine results in increased expression of GPRASP1 mRNA CTD PMID:17456735 NCBI chr  X:98,765,581...98,772,685 JBrowse link
G Gprc5b G protein-coupled receptor, class C, group 5, member B increases expression ISO Nicotine results in increased expression of GPRC5B mRNA CTD PMID:21955143 NCBI chr 1:173,316,398...173,340,951 JBrowse link
G Gprc5c G protein-coupled receptor, class C, group 5, member C multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GPRC5C mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GPRC5C mRNA] CTD PMID:20230807 NCBI chr10:99,886,900...99,908,928 JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression
increases expression
ISO
EXP
Nicotine results in decreased expression of GPX1 mRNA
Nicotine results in increased expression of GPX1 protein
CTD PMID:16949557 PMID:18343235 NCBI chr 8:109,026,905...109,028,031 JBrowse link
G Gpx3 glutathione peroxidase 3 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GPX3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GPX3 mRNA] CTD PMID:20230807 NCBI chr10:39,028,624...39,036,695 JBrowse link
G Gramd1b GRAM domain containing 1B increases expression ISO Nicotine results in increased expression of GRAMD1B mRNA CTD PMID:23825647 NCBI chr 8:40,654,492...40,893,869 JBrowse link
G Grid1 glutamate ionotropic receptor delta type subunit 1 decreases methylation EXP Nicotine results in decreased methylation of GRID1 gene CTD PMID:32994467 NCBI chr16:10,138,564...10,885,803 JBrowse link
G Grid2 glutamate ionotropic receptor delta type subunit 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of GRID2 mRNA; [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GRID2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRID2 mRNA] CTD PMID:20230807 NCBI chr 4:92,415,019...93,892,472 JBrowse link
G Grik2 glutamate ionotropic receptor kainate type subunit 2 increases expression ISO Nicotine results in increased expression of GRIK2 mRNA CTD PMID:17997037 NCBI chr20:52,135,325...52,833,061 JBrowse link
G Grm1 glutamate metabotropic receptor 1 decreases expression EXP Nicotine results in decreased expression of GRM1 mRNA CTD PMID:28339662 NCBI chr 1:5,058,285...5,453,170 JBrowse link
G Grm2 glutamate metabotropic receptor 2 affects expression EXP Nicotine affects the expression of GRM2 mRNA CTD PMID:28339662 NCBI chr 8:107,280,099...107,293,159 JBrowse link
G Grm5 glutamate metabotropic receptor 5 increases expression ISO Nicotine results in increased expression of GRM5 mRNA CTD PMID:21955143 NCBI chr 1:141,310,069...141,884,980 JBrowse link
G Gsdma gasdermin A increases expression ISO Nicotine results in increased expression of GSDMA mRNA CTD PMID:23825647 NCBI chr10:83,614,336...83,639,543 JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha multiple interactions
increases expression
ISO [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of GSK3A protein
Nicotine results in increased expression of GSK3A mRNA
Nicotine results in increased expression of and results in decreased phosphorylation of GSK3A protein
CTD PMID:12511591 PMID:31945395 NCBI chr 1:80,815,843...80,825,732 JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
decreases expression
increases expression
ISO [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of GSK3B protein
Nicotine results in decreased expression of GSK3B mRNA; Nicotine results in decreased expression of GSK3B protein
Nicotine results in increased expression of GSK3B mRNA
Nicotine promotes the reaction [Carbon Tetrachloride results in decreased expression of GSK3B mRNA]; Nicotine promotes the reaction [Carbon Tetrachloride results in decreased expression of GSK3B protein]; Nicotine results in increased expression of and results in decreased phosphorylation of GSK3B protein
CTD PMID:12511591 PMID:31945395 PMID:33640489 NCBI chr11:62,498,997...62,648,665 JBrowse link
G Gsr glutathione-disulfide reductase decreases activity EXP Nicotine results in decreased activity of GSR protein CTD PMID:20498001 NCBI chr16:58,482,209...58,525,256 JBrowse link
G Gsta4 glutathione S-transferase alpha 4 decreases expression
increases expression
increases activity
EXP Nicotine results in decreased expression of GSTA4 mRNA
Nicotine results in increased expression of GSTA4 mRNA
Nicotine results in increased activity of GSTA4 protein
CTD PMID:9774145 NCBI chr 8:79,066,967...79,084,193 JBrowse link
G Gstk1 glutathione S-transferase kappa 1 decreases expression ISO Nicotine results in decreased expression of GSTK1 mRNA CTD PMID:17997037 NCBI chr 4:71,118,979...71,123,298 JBrowse link
G Gstm2 glutathione S-transferase mu 2 decreases expression ISO Nicotine results in decreased expression of GSTM2 mRNA CTD PMID:33640489 NCBI chr 2:195,624,015...195,628,774 JBrowse link
G Guca1a guanylate cyclase activator 1A decreases expression ISO Nicotine results in decreased expression of GUCA1A mRNA CTD PMID:16949557 NCBI chr 9:13,587,695...13,598,566 JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of H2AX protein modified form] CTD PMID:23907605 NCBI chr 8:44,671,927...44,673,257 JBrowse link
G H2az2 H2A.Z variant histone 2 decreases expression ISO Nicotine results in decreased expression of H2AZ2 mRNA CTD PMID:17456735 NCBI chr14:81,293,299...81,312,209 JBrowse link
G Hand1 heart and neural crest derivatives expressed 1 decreases expression EXP
ISO
Nicotine results in decreased expression of HAND1 mRNA; Nicotine results in decreased expression of HAND1 protein CTD PMID:24368670 PMID:31507073 NCBI chr10:42,006,646...42,009,213 JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 increases expression ISO Nicotine results in increased expression of HAVCR1 protein CTD PMID:21511693 NCBI chr10:31,118,667...31,151,730 JBrowse link
G Hba-a1 hemoglobin alpha, adult chain 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of HBA-A1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of HBA-A1 mRNA] CTD PMID:20230807 NCBI chr10:15,337,265...15,338,121 JBrowse link
G Hdac1 histone deacetylase 1 increases expression ISO Nicotine results in increased expression of HDAC1 mRNA CTD PMID:24709674 NCBI chr 5:141,853,992...141,881,057 JBrowse link
G Hdac2 histone deacetylase 2 increases expression
decreases expression
EXP
ISO
Nicotine results in increased expression of HDAC2 mRNA
Nicotine results in decreased expression of HDAC2 protein
CTD PMID:24709674 PMID:31507073 PMID:31846720 NCBI chr20:40,548,250...40,571,609 JBrowse link
G Hdac4 histone deacetylase 4 increases expression
multiple interactions
EXP
ISO
Nicotine results in increased expression of HDAC4 mRNA; Nicotine results in increased expression of HDAC4 protein
Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of HDAC4 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of HDAC4 protein]
CTD PMID:31846720 NCBI chr 9:92,503,467...92,750,164 JBrowse link
G Hdac7 histone deacetylase 7 increases expression ISO Nicotine results in increased expression of HDAC7 mRNA CTD PMID:24709674 NCBI chr 7:128,923,918...128,962,025 JBrowse link
G Hddc2 HD domain containing 2 increases expression ISO Nicotine results in increased expression of HDDC2 mRNA CTD PMID:23825647 NCBI chr 1:26,294,030...26,313,914 JBrowse link
G Hells helicase, lymphoid specific multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HELLS mRNA; Nicotine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HELLS mRNA] CTD PMID:20230807 NCBI chr 1:236,701,704...236,748,239 JBrowse link
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 increases expression ISO Nicotine results in increased expression of HEY1 mRNA CTD PMID:23825647 NCBI chr 2:93,096,706...93,100,316 JBrowse link
G Hgf hepatocyte growth factor affects expression
decreases expression
multiple interactions
EXP
ISO
Nicotine affects the expression of HGF mRNA
Nicotine results in decreased expression of HGF protein
[BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of HGF mRNA
CTD PMID:32512034 PMID:33091441 NCBI chr 4:18,673,736...18,745,582 JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression
decreases expression
multiple interactions
ISO Nicotine results in increased expression of HIF1A protein
Nicotine results in decreased expression of HIF1A mRNA
resveratrol inhibits the reaction [Nicotine results in decreased expression of HIF1A mRNA]
CHRNA5 mutant form inhibits the reaction [Nicotine results in increased expression of HIF1A protein]
CTD PMID:22687363 PMID:24793809 NCBI chr 6:92,624,059...92,669,262 JBrowse link
G Hint1 histidine triad nucleotide binding protein 1 multiple interactions
increases expression
ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HINT1 mRNA; Mecamylamine inhibits the reaction [Nicotine results in increased expression of HINT1 protein]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HINT1 mRNA]
Nicotine results in increased expression of HINT1 mRNA
CTD PMID:20230807 PMID:20514075 NCBI chr10:38,989,516...38,993,259 JBrowse link
G Hipk1 homeodomain interacting protein kinase 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of HIPK1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HIPK1 mRNA] CTD PMID:20230807 NCBI chr 2:191,248,817...191,299,787 JBrowse link
G Hist1h2bc histone cluster 1, H2bc decreases expression ISO Nicotine results in decreased expression of H2BC4 mRNA CTD PMID:17456735 NCBI chr17:42,692,335...42,696,860 JBrowse link
G Hltf helicase-like transcription factor decreases expression ISO Nicotine results in decreased expression of HLTF mRNA CTD PMID:18247414 NCBI chr 2:102,549,724...102,609,492 JBrowse link
G Hmga1 high mobility group AT-hook 1 decreases expression ISO Nicotine results in decreased expression of HMGA1 mRNA CTD PMID:16949557 NCBI chr20:5,611,088...5,618,755 JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression
affects expression
ISO
EXP
Nicotine results in increased expression of HMGCR mRNA
Nicotine affects the expression of HMGCR mRNA
CTD PMID:23416264 PMID:31972234 NCBI chr 2:27,997,523...28,018,983 JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO Nicotine results in increased expression of HMGCS1 mRNA CTD PMID:21955143 NCBI chr 2:51,649,368...51,667,100 JBrowse link
G Hmox1 heme oxygenase 1 increases response to substance
affects expression
increases expression
multiple interactions
ISO
EXP
HMOX1 protein results in increased susceptibility to Nicotine
Nicotine affects the expression of HMOX1 mRNA
Nicotine results in increased expression of HMOX1 mRNA; Nicotine results in increased expression of HMOX1 protein
[Lipopolysaccharides co-treated with Nicotine] results in increased expression of HMOX1 mRNA; [Lipopolysaccharides co-treated with Nicotine] results in increased expression of HMOX1 protein; [Nicotine co-treated with polylactic acid-polyglycolic acid copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HMOX1 protein]; HMOX1 protein promotes the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of ZFP36 mRNA]; HMOX1 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; HMOX1 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of ZFP36 mRNA]]; HMOX1 protein promotes the reaction [Nicotine results in increased expression of ZFP36 mRNA]; HMOX1 protein promotes the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HMOX1 protein]; STAT3 protein promotes the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of HMOX1 mRNA]
CTD PMID:22954530 PMID:23933227 PMID:23942037 PMID:24095726 NCBI chr19:13,466,287...13,474,082 JBrowse link
G Hnrnpa3 heterogeneous nuclear ribonucleoprotein A3 increases expression ISO Nicotine results in increased expression of HNRNPA3 mRNA CTD PMID:17456735 NCBI chr 3:60,578,574...60,588,755 JBrowse link
G Hnrnpc heterogeneous nuclear ribonucleoprotein C multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of HNRNPC mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of HNRNPC mRNA] CTD PMID:20230807 NCBI chr15:24,779,593...24,809,213 JBrowse link
G Hnrnph2 heterogeneous nuclear ribonucleoprotein H2 increases expression ISO Nicotine results in increased expression of HNRNPH2 mRNA CTD PMID:17456735 NCBI chr  X:97,780,890...97,786,846 JBrowse link
G Hnrnpl heterogeneous nuclear ribonucleoprotein L decreases expression ISO Nicotine results in decreased expression of HNRNPL mRNA CTD PMID:21955143 NCBI chr 1:84,098,558...84,111,568 JBrowse link
G Hnrnpll heterogeneous nuclear ribonucleoprotein L-like increases expression ISO Nicotine results in increased expression of HNRNPLL mRNA CTD PMID:17997037 NCBI chr 6:14,969,953...15,000,574 JBrowse link
G Hnrnpr heterogeneous nuclear ribonucleoprotein R increases expression ISO Nicotine results in increased expression of HNRNPR mRNA CTD PMID:17997037 NCBI chr 5:148,542,999...148,574,888 JBrowse link
G Homer1 homer scaffold protein 1 decreases expression ISO Nicotine results in decreased expression of HOMER1 mRNA CTD PMID:21955143 NCBI chr 2:24,542,777...24,645,715 JBrowse link
G Hoxb9 homeo box B9 increases expression ISO Nicotine results in increased expression of HOXB9 mRNA CTD PMID:23825647 NCBI chr10:81,237,312...81,240,818 JBrowse link
G Hp1bp3 heterochromatin protein 1, binding protein 3 increases expression ISO Nicotine results in increased expression of HP1BP3 mRNA CTD PMID:16949557 NCBI chr 5:150,435,781...150,463,004 JBrowse link
G Hpca hippocalcin increases expression ISO Nicotine results in increased expression of HPCA mRNA CTD PMID:21955143 NCBI chr 5:141,455,616...141,466,252 JBrowse link
G Hpcal4 hippocalcin-like 4 increases expression ISO Nicotine results in increased expression of HPCAL4 mRNA CTD PMID:23825647 NCBI chr 5:135,454,477...135,466,417 JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions
increases activity
ISO
EXP
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of HRAS mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of HRAS mRNA]
Nicotine results in increased activity of HRAS protein
CTD PMID:15983034 PMID:20230807 NCBI chr 1:196,290,127...196,299,823 JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 increases expression
affects expression
multiple interactions
EXP
ISO
Nicotine results in increased expression of HSD11B1 mRNA
Nicotine affects the expression of HSD11B1 mRNA
ursodoxicoltaurine inhibits the reaction [Nicotine results in increased expression of HSD11B1 mRNA]
CTD PMID:21955143 PMID:22265867 PMID:26803847 PMID:31972234 NCBI chr13:104,728,539...104,798,884 JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 decreases expression
affects expression
increases expression
multiple interactions
EXP
ISO
Nicotine results in decreased expression of HSD11B2 mRNA; Nicotine results in decreased expression of HSD11B2 protein
Nicotine affects the expression of HSD11B2 mRNA
Nicotine results in increased expression of HSD11B2 mRNA; Nicotine results in increased expression of HSD11B2 protein
2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide inhibits the reaction [Nicotine results in decreased expression of HSD11B2 mRNA]; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide inhibits the reaction [Nicotine results in decreased expression of HSD11B2 protein]; EGR1 protein promotes the reaction [Nicotine results in decreased expression of HSD11B2 mRNA]; EGR1 protein promotes the reaction [Nicotine results in decreased expression of HSD11B2 protein]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of HSD11B2 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of HSD11B2 protein]
CTD PMID:22265867 PMID:29486207 PMID:31972234 NCBI chr19:33,397,656...33,402,899 JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 multiple interactions
decreases expression
EXP
ISO
Taurine inhibits the reaction [Nicotine results in decreased expression of HSD17B1 protein]
Nicotine results in decreased expression of HSD17B1 mRNA
Nicotine results in decreased expression of HSD17B1 mRNA; Nicotine results in decreased expression of HSD17B1 protein
CTD PMID:20498001 PMID:30959089 NCBI chr10:86,009,728...86,011,928 JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 decreases activity
decreases expression
EXP Nicotine results in decreased activity of HSD17B3 protein
Nicotine results in decreased expression of HSD17B3 mRNA; Nicotine results in decreased expression of HSD17B3 protein
CTD PMID:28986172 NCBI chr17:1,027,229...1,058,554 JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 increases splicing ISO Nicotine results in increased splicing of HSD17B7 mRNA alternative form CTD PMID:23825647 NCBI chr13:82,170,079...82,190,018 JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression
decreases activity
EXP
ISO
Nicotine results in decreased expression of HSD3B1 mRNA; Nicotine results in decreased expression of HSD3B1 protein
Nicotine results in decreased activity of HSD3B1 protein
CTD PMID:28986172 PMID:30959089 NCBI chr 2:186,169,864...186,175,984 JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 multiple interactions
increases expression
ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HSP90AA1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HSP90AA1 mRNA]
Nicotine results in increased expression of HSP90AA1 mRNA; Nicotine results in increased expression of HSP90AA1 protein
CTD PMID:12115584 PMID:20230807 NCBI chr 6:129,702,376...129,707,907 JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions
ISO
EXP
Nicotine results in increased expression of HSPA5
Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HSPA5 protein]
Nicotine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HSPA5 protein]; Nicotine inhibits the reaction [Tunicamycin results in increased expression of HSPA5 protein]
CTD PMID:18477628 PMID:24201001 PMID:28082123 NCBI chr 3:18,055,507...18,059,969 JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 multiple interactions ISO Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HSPE1 mRNA] CTD PMID:20230807 NCBI chr 9:56,589,912...56,593,000 JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A decreases expression
increases expression
ISO
EXP
Nicotine results in decreased expression of HTR1A protein
Nicotine results in increased expression of HTR1A protein
CTD PMID:21324836 PMID:30247698 NCBI chr 2:36,694,174...36,695,442 JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B multiple interactions EXP Nicotine results in increased activity of [HTR1B protein binds to HTR2A protein] CTD PMID:21316381 NCBI chr 8:82,513,572...82,534,892 JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions
increases expression
EXP [Nicotine co-treated with Benzo(a)pyrene] results in decreased expression of HTR2A protein; Nicotine results in increased activity of [HTR1B protein binds to HTR2A protein]
Nicotine results in increased expression of HTR2A protein
CTD PMID:21316381 PMID:30247698 NCBI chr15:49,950,035...50,022,188 JBrowse link
G Ibsp integrin-binding sialoprotein decreases expression EXP Nicotine results in decreased expression of IBSP mRNA CTD PMID:29981921 NCBI chr14:5,439,825...5,452,570 JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression EXP Nicotine results in increased expression of ICAM1 protein CTD PMID:12575837 NCBI chr 8:19,553,063...19,565,438 JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein decreases expression ISO Nicotine results in decreased expression of ID1 mRNA CTD PMID:17997037 NCBI chr 3:141,210,666...141,212,420 JBrowse link
G Id2 inhibitor of DNA binding 2 increases splicing ISO Nicotine results in increased splicing of ID2 mRNA alternative form CTD PMID:23825647 NCBI chr 6:41,740,556...41,742,393 JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein decreases expression ISO Nicotine results in decreased expression of ID3 mRNA CTD PMID:17456735 NCBI chr 5:148,372,784...148,374,353 JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 decreases expression
increases expression
ISO Nicotine results in decreased expression of IDI1 mRNA
Nicotine results in increased expression of IDI1 mRNA
CTD PMID:16949557 PMID:17997037 NCBI chr17:61,629,592...61,637,357 JBrowse link
G Ifi27 interferon, alpha-inducible protein 27 increases expression ISO Nicotine results in increased expression of IFI27 mRNA CTD PMID:23825647 NCBI chr 6:122,590,461...122,596,996 JBrowse link
G Ifi44 interferon-induced protein 44 increases expression ISO Nicotine results in increased expression of IFI44 mRNA CTD PMID:23825647 NCBI chr 2:240,626,058...240,643,879 JBrowse link
G Ifi44l interferon-induced protein 44-like increases expression ISO Nicotine results in increased expression of IFI44L mRNA CTD PMID:23825647 NCBI chr 2:240,668,742...240,706,425 JBrowse link
G Ifih1 interferon induced with helicase C domain 1 multiple interactions ISO Nicotine inhibits the reaction [Poly I-C results in increased expression of IFIH1 mRNA] CTD PMID:31154625 NCBI chr 3:47,228,980...47,275,403 JBrowse link
G Ifnar1 interferon alpha and beta receptor subunit 1 decreases expression ISO Nicotine results in decreased expression of IFNAR1 mRNA CTD PMID:18247414 NCBI chr11:30,725,774...30,752,227 JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO IRF7 protein mutant form affects the reaction [Nicotine inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]]; IRF7 protein mutant form inhibits the reaction [Nicotine inhibits the reaction [Poly I-C results in increased secretion of IFNB1 protein]]; Nicotine inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; Nicotine inhibits the reaction [Poly I-C results in increased secretion of IFNB1 protein] CTD PMID:31154625 NCBI chr 5:103,020,969...103,021,523 JBrowse link
G Ifng interferon gamma multiple interactions ISO Nicotine inhibits the reaction [IFNG protein results in increased expression of TNF mRNA] CTD PMID:24095726 NCBI chr 7:53,903,339...53,907,375 JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression
affects expression
increases expression
multiple interactions
EXP Nicotine results in decreased expression of IGF1 mRNA; Nicotine results in decreased expression of IGF1 protein
Nicotine affects the expression of IGF1 mRNA; Nicotine affects the expression of IGF1 protein
Nicotine results in increased expression of IGF1 mRNA
rosiglitazone inhibits the reaction [Nicotine results in decreased expression of IGF1 protein]
CTD PMID:20960268 PMID:22265867 PMID:29486207 PMID:31972234 NCBI chr 7:22,282,895...22,361,972 JBrowse link
G Igf1r insulin-like growth factor 1 receptor decreases expression
affects expression
increases expression
EXP Nicotine results in decreased expression of IGF1R mRNA; Nicotine results in decreased expression of IGF1R protein
Nicotine affects the expression of IGF1R mRNA
Nicotine results in increased expression of IGF1R mRNA
CTD PMID:20426880 PMID:20960268 PMID:22265867 PMID:31972234 NCBI chr 1:121,549,839...121,838,545 JBrowse link
G Igf2 insulin-like growth factor 2 increases expression EXP Nicotine results in increased expression of IGF2 mRNA CTD PMID:29486207 NCBI chr 1:197,814,409...197,831,802 JBrowse link
G Igf2bp2 insulin-like growth factor 2 mRNA binding protein 2 increases expression ISO Nicotine results in increased expression of IGF2BP2 mRNA CTD PMID:17997037 NCBI chr11:78,874,402...78,974,392 JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 increases expression ISO Nicotine results in increased expression of IGFBP2 mRNA CTD PMID:23825647 NCBI chr 9:74,415,574...74,442,945 JBrowse link
G Igsf1 immunoglobulin superfamily, member 1 decreases expression ISO Nicotine results in decreased expression of IGSF1 mRNA CTD PMID:21955143 NCBI chr  X:129,069,891...129,085,331 JBrowse link
G Igsf3 immunoglobulin superfamily, member 3 increases expression ISO Nicotine results in increased expression of IGSF3 mRNA CTD PMID:23825647 NCBI chr 2:188,811,394...188,899,645 JBrowse link
G Ihh Indian hedgehog signaling molecule increases expression EXP Nicotine results in increased expression of IHH mRNA CTD PMID:27782041 NCBI chr 9:76,504,315...76,510,532 JBrowse link
G Il10 interleukin 10 decreases expression
multiple interactions
decreases secretion
ISO Nicotine results in decreased expression of IL10 mRNA
Nicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL10 protein]
Nicotine results in decreased secretion of IL10 protein
[Eugenol co-treated with Acetylcysteine] inhibits the reaction [Nicotine results in decreased secretion of IL10 protein]; Acetylcysteine inhibits the reaction [Nicotine results in decreased expression of IL10 mRNA]; Eugenol inhibits the reaction [Nicotine results in decreased expression of IL10 mRNA]; Nicotine inhibits the reaction [Dextran Sulfate results in decreased expression of IL10 protein]
CTD PMID:18247414 PMID:21237301 PMID:29673796 PMID:31926917 NCBI chr13:42,472,625...42,477,308 JBrowse link
G Il12a interleukin 12A multiple interactions ISO Acetylcysteine inhibits the reaction [Nicotine results in increased secretion of [IL12A protein co-treated with IL12B protein]]; Eugenol inhibits the reaction [Nicotine results in increased secretion of [IL12A protein co-treated with IL12B protein]]; Nicotine results in increased secretion of [IL12A protein co-treated with IL12B protein] CTD PMID:21237301 NCBI chr 2:152,965,769...152,973,035 JBrowse link
G Il12b interleukin 12B multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [Nicotine results in increased expression of IL12B mRNA]; Acetylcysteine inhibits the reaction [Nicotine results in increased secretion of [IL12A protein co-treated with IL12B protein]]; Eugenol inhibits the reaction [Nicotine results in increased expression of IL12B mRNA]; Eugenol inhibits the reaction [Nicotine results in increased secretion of [IL12A protein co-treated with IL12B protein]]; Nicotine results in increased secretion of [IL12A protein co-treated with IL12B protein] CTD PMID:21237301 NCBI chr10:28,888,832...28,903,796 JBrowse link
G Il17a interleukin 17A multiple interactions ISO [Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL17A mRNA; resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL17A mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL17A mRNA] CTD PMID:23199342 NCBI chr 9:23,144,402...23,147,889 JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Nicotine results in increased expression of and results in increased secretion of IL1A protein CTD PMID:18082304 NCBI chr 3:116,526,601...116,537,055 JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases secretion
decreases expression
increases expression
ISO
EXP
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine promotes the reaction [IL1B protein results in increased expression of CXCL8 protein]]; [Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL1B mRNA; Nicotine inhibits the reaction [3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased secretion of IL1B protein]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; Nicotine promotes the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; Nicotine promotes the reaction [IL1B protein results in increased expression of CXCL8 protein]; Nicotine promotes the reaction [IL1B protein results in increased secretion of CXCL8 protein]; Nicotine results in increased expression of and results in increased secretion of IL1B protein; Resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL1B mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL1B mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased secretion of IL1B protein]; Tubocurarine inhibits the reaction [Nicotine promotes the reaction [IL1B protein results in increased expression of CXCL8 mRNA]]; Tubocurarine inhibits the reaction [Nicotine promotes the reaction [IL1B protein results in increased secretion of CXCL8 protein]]; U 0126 inhibits the reaction [Nicotine promotes the reaction [IL1B protein results in increased expression of CXCL8 protein]]
Nicotine results in increased secretion of IL1B protein
Nicotine results in decreased expression of IL1B protein
[Nicotine results in increased abundance of Cotinine] which results in increased expression of IL1B mRNA; Nicotine inhibits the reaction [Acetic Acid results in increased expression of IL1B protein]; Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B mRNA]
Nicotine results in increased expression of IL1B mRNA
Nicotine results in increased expression of IL1B protein
Nicotine inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
CTD PMID:15976189 PMID:16254210 PMID:18082304 PMID:19673871 PMID:20943775 PMID:22119045 PMID:23199342 PMID:23810507 PMID:24095726 PMID:27180639 PMID:27766701 PMID:27984197 PMID:29617909 PMID:29642561 PMID:31926917 PMID:32473187 NCBI chr 3:116,577,005...116,583,386 JBrowse link
G Il1r1 interleukin 1 receptor type 1 multiple interactions
increases expression
EXP methyllycaconitine affects the reaction [Nicotine results in increased expression of IL1R1 mRNA]; methyllycaconitine affects the reaction [Nicotine results in increased expression of IL1R1 protein]
Nicotine results in increased expression of IL1R1 mRNA; Nicotine results in increased expression of IL1R1 protein
CTD PMID:27180639 NCBI chr 9:42,504,917...42,580,958 JBrowse link
G Il1rn interleukin 1 receptor antagonist multiple interactions EXP IL1RN protein inhibits the reaction [Nicotine results in increased activity of Capsaicin] CTD PMID:27180639 NCBI chr 3:7,111,567...7,127,451 JBrowse link
G Il2 interleukin 2 decreases response to substance ISO Nicotine results in decreased susceptibility to IL2 protein CTD PMID:15231866 NCBI chr 2:120,004,862...120,009,566 JBrowse link
G Il33 interleukin 33 increases secretion
multiple interactions
ISO Nicotine results in increased secretion of IL33 protein
Nicotine promotes the reaction [Lipopolysaccharides results in increased secretion of IL33 protein]
CTD PMID:29673796 NCBI chr 1:227,701,964...227,736,374 JBrowse link
G Il3ra interleukin 3 receptor subunit alpha decreases expression ISO Nicotine results in decreased expression of IL3RA mRNA CTD PMID:18247414 NCBI chr12:16,318,081...16,323,781 JBrowse link
G Il4r interleukin 4 receptor multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of IL4RA mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL4RA mRNA] CTD PMID:20230807 NCBI chr 1:180,115,061...180,139,981 JBrowse link
G Il6 interleukin 6 multiple interactions
increases secretion
decreases secretion
decreases expression
increases expression
ISO
EXP
[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL6 mRNA; [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased secretion of IL6 protein; [Nicotine co-treated with Propylene Glycol co-treated with Glycerol] results in increased secretion of IL6 protein; Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Nicotine results in increased expression of and results in increased secretion of IL6 protein; Resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL6 mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL6 mRNA]
Nicotine results in increased secretion of IL6 protein
[Nicotine results in increased abundance of Cotinine] which results in increased expression of IL6 mRNA
Nicotine results in decreased secretion of IL6 protein
Nicotine results in decreased expression of IL6 mRNA; Nicotine results in decreased expression of IL6 protein
Nicotine results in increased expression of IL6 mRNA
Nicotine inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; ZFP36 mutant form inhibits the reaction [Nicotine results in decreased expression of IL6 mRNA]
CTD PMID:18082304 PMID:19673871 PMID:20943775 PMID:22093924 PMID:23199342 PMID:25396421 PMID:28065790 PMID:29617909 PMID:29673796 PMID:31926917 PMID:32473187 NCBI chr 4:5,214,602...5,219,178 JBrowse link
G Il7 interleukin 7 multiple interactions ISO Nicotine results in increased expression of and results in increased secretion of IL7 protein CTD PMID:18082304 NCBI chr 2:94,235,219...94,280,075 JBrowse link
G Il9 interleukin 9 decreases expression ISO Nicotine results in decreased expression of IL9 mRNA CTD PMID:18247414 NCBI chr17:8,111,772...8,114,895 JBrowse link
G Inppl1 inositol polyphosphate phosphatase-like 1 decreases expression ISO Nicotine results in decreased expression of INPPL1 mRNA CTD PMID:17456735 NCBI chr 1:156,183,043...156,197,500 JBrowse link
G Ins2 insulin 2 increases expression EXP Nicotine results in increased expression of INS2 mRNA CTD PMID:20426880 NCBI chr 1:197,843,277...197,992,522 JBrowse link
G Insig1 insulin induced gene 1 increases expression
decreases expression
ISO
EXP
Nicotine results in increased expression of INSIG1 mRNA
Nicotine results in decreased expression of INSIG1 mRNA
CTD PMID:23416264 PMID:26776438 NCBI chr 4:7,315,494...7,323,972 JBrowse link
G Insr insulin receptor decreases expression EXP Nicotine results in decreased expression of INSR mRNA; Nicotine results in decreased expression of INSR protein CTD PMID:20960268 PMID:22265867 NCBI chr12:1,193,193...1,330,976 JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of IRAK1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IRAK1 mRNA] CTD PMID:20230807 NCBI chr  X:151,768,621...151,778,521 JBrowse link
G Irf7 interferon regulatory factor 7 multiple interactions ISO IRF7 protein mutant form affects the reaction [Nicotine inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]]; IRF7 protein mutant form inhibits the reaction [Nicotine inhibits the reaction [Poly I-C results in increased secretion of IFNB1 protein]]; Nicotine inhibits the reaction [Poly I-C results in increased expression of IRF7 mRNA] CTD PMID:31154625 NCBI chr 1:196,367,380...196,370,943 JBrowse link
G Irf8 interferon regulatory factor 8 decreases expression ISO Nicotine results in decreased expression of IRF8 mRNA CTD PMID:17456735 NCBI chr19:48,790,483...48,812,363 JBrowse link
G Irf9 interferon regulatory factor 9 increases expression ISO Nicotine results in increased expression of IRF9 mRNA CTD PMID:33640489 NCBI chr15:29,095,474...29,101,924 JBrowse link
G Irs1 insulin receptor substrate 1 decreases expression EXP Nicotine results in decreased expression of IRS1 mRNA CTD PMID:22265867 NCBI chr 9:83,552,964...83,605,797 JBrowse link
G Irx3 iroquois homeobox 3 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of IRX3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of IRX3 mRNA] CTD PMID:20230807 NCBI chr19:15,211,882...15,215,323 JBrowse link
G Isg15 ISG15 ubiquitin-like modifier multiple interactions ISO Nicotine inhibits the reaction [Poly I-C results in increased expression of ISG15 mRNA] CTD PMID:31154625 NCBI chr 5:166,784,148...166,785,435 JBrowse link
G Itga2b integrin subunit alpha 2b decreases expression ISO Nicotine results in decreased expression of ITGA2B mRNA; Nicotine results in decreased expression of ITGA2B protein CTD PMID:21385097 NCBI chr10:87,408,532...87,426,055 JBrowse link
G Itgal integrin subunit alpha L decreases expression ISO Nicotine results in decreased expression of ITGAL mRNA CTD PMID:18247414 NCBI chr 1:181,918,183...181,955,735 JBrowse link
G Itgav integrin subunit alpha V increases expression ISO Nicotine results in increased expression of ITGAV mRNA CTD PMID:17997037 NCBI chr 3:68,838,524...68,926,653 JBrowse link
G Itgb1 integrin subunit beta 1 decreases expression ISO Nicotine results in decreased expression of ITGB1 protein CTD PMID:11338295 NCBI chr19:56,705,123...56,753,199 JBrowse link
G Itgb3 integrin subunit beta 3 decreases expression ISO Nicotine results in decreased expression of ITGB3 mRNA; Nicotine results in decreased expression of ITGB3 protein CTD PMID:21385097 NCBI chr10:89,509,917...89,564,679 JBrowse link
G Itgb5 integrin subunit beta 5 increases expression EXP Nicotine results in increased expression of ITGB5 mRNA CTD PMID:20426880 NCBI chr11:66,828,428...66,944,231 JBrowse link
G Itm2b integral membrane protein 2B multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ITM2B mRNA; Nicotine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ITM2B mRNA] CTD PMID:20230807 NCBI chr15:48,545,998...48,568,904 JBrowse link
G Itpkb inositol-trisphosphate 3-kinase B increases expression EXP Nicotine results in increased expression of ITPKB mRNA CTD PMID:11478936 NCBI chr13:92,069,160...92,164,281 JBrowse link
G Ivl involucrin decreases expression ISO Nicotine results in decreased expression of IVL protein CTD PMID:16011614 NCBI chr 2:178,146,694...178,160,807 JBrowse link
G Jagn1 jagunal homolog 1 decreases expression ISO Nicotine results in decreased expression of JAGN1 mRNA CTD PMID:17997037 NCBI chr 4:146,591,577...146,596,287 JBrowse link
G Jak2 Janus kinase 2 increases response to substance
decreases expression
ISO
EXP
JAK2 results in increased susceptibility to Nicotine
Nicotine results in decreased expression of JAK2 mRNA
CTD PMID:20943775 PMID:29155039 NCBI chr 1:226,995,334...227,054,381 JBrowse link
G Jmjd6 jumonji domain containing 6, arginine demethylase and lysine hydroxylase multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of JMJD6 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of JMJD6 mRNA] CTD PMID:20230807 NCBI chr10:102,041,131...102,047,182 JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
increases phosphorylation
ISO
EXP
Nicotine results in increased expression of JUN protein
Nicotine promotes the reaction [MAPK8 protein results in increased phosphorylation of JUN protein]
Nicotine results in increased phosphorylation of JUN protein
[U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of JUN protein]; Nicotine inhibits the reaction [Cisplatin results in increased expression of JUN mRNA]
CTD PMID:11592233 PMID:17003101 PMID:17021677 PMID:21511693 NCBI chr 5:109,894,175...109,897,268 JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit increases expression
decreases expression
ISO Nicotine results in increased expression of JUNB mRNA
Nicotine results in decreased expression of JUNB mRNA
CTD PMID:17456735 PMID:17997037 PMID:18805435 PMID:21955143 NCBI chr19:23,176,265...23,178,049 JBrowse link
G Kat6b lysine acetyltransferase 6B multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of KAT6B mRNA; Nicotine affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of KAT6B mRNA] CTD PMID:20230807 NCBI chr15:2,638,885...2,811,977 JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 increases expression ISO Nicotine results in increased expression of KCNH2 mRNA CTD PMID:17997037 NCBI chr 4:10,826,834...10,859,009 JBrowse link
G Kcnk1 potassium two pore domain channel subfamily K member 1 decreases expression EXP Nicotine results in decreased expression of KCNK1 mRNA CTD PMID:11478936 NCBI chr19:53,959,411...53,997,726 JBrowse link
G Kdm7a lysine demethylase 7A increases expression ISO Nicotine results in increased expression of KDM7A mRNA CTD PMID:16949557 NCBI chr 4:67,899,407...67,974,264 JBrowse link
G Kdr kinase insert domain receptor increases expression
decreases expression
EXP Nicotine results in increased expression of KDR mRNA
Nicotine results in decreased expression of KDR protein
CTD PMID:32512034 PMID:33091441 NCBI chr14:32,217,871...32,261,018 JBrowse link
G Kif21b kinesin family member 21B increases expression ISO Nicotine results in increased expression of KIF21B mRNA CTD PMID:23825647 NCBI chr13:47,576,142...47,626,112 JBrowse link
G Kif3b kinesin family member 3B multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of KIF3B mRNA; Nicotine affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of KIF3B mRNA] CTD PMID:20230807 NCBI chr 3:141,758,466...141,798,012 JBrowse link
G Klf10 Kruppel-like factor 10 decreases expression
increases expression
ISO Nicotine results in decreased expression of KLF10 mRNA
Nicotine results in increased expression of KLF10 mRNA
CTD PMID:17456735 PMID:17997037 NCBI chr 7:69,467,658...69,473,726 JBrowse link
G Klf11 Kruppel-like factor 11 decreases expression ISO Nicotine results in decreased expression of KLF11 mRNA CTD PMID:18247414 NCBI chr 6:41,285,699...41,297,548 JBrowse link
G Klf4 Kruppel like factor 4 multiple interactions
increases expression
ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of KLF4 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of KLF4 mRNA]
Nicotine results in increased expression of KLF4 mRNA
CTD PMID:17456735 PMID:20230807 NCBI chr 5:70,278,843...70,283,751 JBrowse link
G Klk5 kallikrein related-peptidase 5 increases expression ISO Nicotine results in increased expression of KLK5 mRNA CTD PMID:23825647 NCBI chr 1:94,296,574...94,304,768 JBrowse link
G Kmt2c lysine methyltransferase 2C multiple interactions
decreases expression
ISO alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of KMT2C mRNA]; Mecamylamine inhibits the reaction [Nicotine results in decreased expression of KMT2C mRNA]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of KMT2C mRNA] CTD PMID:12588870 NCBI chr 4:9,620,638...9,834,787 JBrowse link
G Kng2 kininogen 2 multiple interactions
decreases activity
EXP Capsaicin promotes the reaction [Nicotine results in decreased activity of KNG1 protein alternative form]; Kainic Acid promotes the reaction [Nicotine results in decreased activity of KNG1 protein alternative form] CTD PMID:7807204 NCBI chr11:77,913,876...77,936,247 JBrowse link
G Krt15 keratin 15 increases expression ISO Nicotine results in increased expression of KRT15 mRNA CTD PMID:23825647 NCBI chr10:85,066,797...85,070,614 JBrowse link
G Krt80 keratin 80 increases expression ISO Nicotine results in increased expression of KRT80 mRNA CTD PMID:23825647 NCBI chr 7:132,464,807...132,485,026 JBrowse link
G Krt85 keratin 85 increases expression ISO Nicotine results in increased expression of KRT85 mRNA CTD PMID:23825647 NCBI chr 7:132,630,184...132,636,988 JBrowse link
G Lamb1 laminin subunit beta 1 increases expression ISO Nicotine results in increased expression of LAMB1 mRNA CTD PMID:16949557 NCBI chr 6:47,835,492...47,902,585 JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 decreases expression ISO Nicotine results in decreased expression of LAMP2 protein CTD PMID:33010382 NCBI chr  X:117,173,097...117,222,090 JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase multiple interactions ISO LCK protein promotes the reaction [Nicotine results in increased phosphorylation of and results in increased activity of FYN protein]; Nicotine results in increased phosphorylation of and results in increased activity of LCK protein CTD PMID:17709503 NCBI chr 5:141,888,319...141,916,992 JBrowse link
G Lcp1 lymphocyte cytosolic protein 1 affects response to substance ISO LCP1 gene SNP affects the susceptibility to Nicotine CTD PMID:18438686 NCBI chr15:50,443,300...50,544,682 JBrowse link
G Ldlr low density lipoprotein receptor increases expression ISO Nicotine results in increased expression of LDLR mRNA CTD PMID:23416264 NCBI chr 8:20,270,020...20,292,981 JBrowse link
G Ldlrad3 low density lipoprotein receptor class A domain containing 3 increases splicing ISO Nicotine results in increased splicing of LDLRAD3 mRNA alternative form CTD PMID:23825647 NCBI chr 3:88,239,529...88,481,291 JBrowse link
G Lep leptin increases expression
decreases response to substance
EXP Nicotine results in increased expression of LEP protein
Nicotine results in decreased susceptibility to LEP protein
CTD PMID:23623838 PMID:29155039 NCBI chr 4:57,661,127...57,675,262 JBrowse link
G Lepr leptin receptor increases expression
decreases expression
EXP Nicotine results in increased expression of LEPR mRNA
Nicotine results in decreased expression of LEPR mRNA
CTD PMID:22265867 PMID:29155039 NCBI chr 5:116,294,409...116,477,904 JBrowse link
G Lgals1 galectin 1 increases expression ISO Nicotine results in increased expression of LGALS1 mRNA CTD PMID:23825647 NCBI chr 7:110,485,239...110,488,345 JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression EXP Nicotine results in decreased expression of LHB mRNA; Nicotine results in decreased expression of LHB protein CTD PMID:20498001 PMID:28986172 NCBI chr 1:95,898,269...95,901,973 JBrowse link
G Lig4 DNA ligase 4 increases expression ISO Nicotine results in increased expression of LIG4 mRNA CTD PMID:16949557 NCBI chr16:79,518,393...79,526,956 JBrowse link
G Lin7c lin-7 homolog C, crumbs cell polarity complex component decreases expression ISO Nicotine results in decreased expression of LIN7C mRNA CTD PMID:21955143 NCBI chr 3:96,406,825...96,414,137 JBrowse link
G Lipe lipase E, hormone sensitive type decreases expression EXP Nicotine results in decreased expression of LIPE mRNA CTD PMID:29155039 NCBI chr 1:80,965,612...80,984,313 JBrowse link
G Litaf lipopolysaccharide-induced TNF factor multiple interactions
increases expression
decreases expression
ISO alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of LITAF mRNA]; Mecamylamine promotes the reaction [Nicotine results in decreased expression of LITAF mRNA]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of LITAF mRNA]
Nicotine results in increased expression of LITAF mRNA
CTD PMID:12588870 PMID:21955143 NCBI chr10:4,656,308...4,692,981 JBrowse link
G Lmo7 LIM domain 7 decreases expression ISO Nicotine results in decreased expression of LMO7 mRNA CTD PMID:21955143 NCBI chr15:78,567,029...78,769,833 JBrowse link
G LOC100909544 bromodomain-containing protein 2-like increases expression ISO Nicotine results in increased expression of BRD2 mRNA CTD PMID:33640489
G LOC102555183 zinc finger protein OZF-like increases expression ISO Nicotine results in increased expression of ZNF146 mRNA CTD PMID:16949557 NCBI chr 1:85,409,570...85,421,884 JBrowse link
G Lpar4 lysophosphatidic acid receptor 4 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of LPAR4 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of LPAR4 mRNA] CTD PMID:20230807 NCBI chr  X:72,033,486...72,046,978 JBrowse link
G Lpl lipoprotein lipase increases expression ISO Nicotine results in increased expression of LPL mRNA CTD PMID:21955143 NCBI chr16:20,830,055...20,853,855 JBrowse link
G Lrrfip1 LRR binding FLII interacting protein 1 increases expression ISO Nicotine results in increased expression of LRRFIP1 mRNA CTD PMID:16949557 NCBI chr 9:91,592,032...91,720,250 JBrowse link
G Lrrtm4 leucine rich repeat transmembrane neuronal 4 increases methylation EXP Nicotine results in increased methylation of LRRTM4 gene CTD PMID:32994467 NCBI chr 4:112,545,874...113,338,713 JBrowse link
G Ltb lymphotoxin beta decreases expression ISO Nicotine results in decreased expression of LTB mRNA CTD PMID:18247414 NCBI chr20:3,627,536...3,629,381 JBrowse link
G Ltf lactotransferrin decreases expression ISO Nicotine results in decreased expression of LTF mRNA CTD PMID:23825647 NCBI chr 8:110,999,948...111,022,795 JBrowse link
G Ltn1 listerin E3 ubiquitin protein ligase 1 multiple interactions ISO [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of LTN1 mRNA CTD PMID:28065790 NCBI chr11:26,603,903...26,660,871 JBrowse link
G Lyl1 LYL1, basic helix-loop-helix family member decreases expression ISO Nicotine results in decreased expression of LYL1 mRNA CTD PMID:17456735 NCBI chr19:23,452,140...23,455,007 JBrowse link
G Lysmd3 LysM domain containing 3 affects response to substance ISO LYSMD3 gene SNP affects the susceptibility to Nicotine CTD PMID:18438686 NCBI chr 2:11,933,787...11,939,944 JBrowse link
G Madd MAP-kinase activating death domain decreases expression ISO Nicotine results in decreased expression of MADD mRNA CTD PMID:18247414 NCBI chr 3:77,114,330...77,157,865 JBrowse link
G Maoa monoamine oxidase A multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of MAOA mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MAOA mRNA] CTD PMID:20230807 NCBI chr  X:6,032,172...6,098,308 JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 increases expression EXP Nicotine results in increased expression of MAP2K6 mRNA CTD PMID:20426880 NCBI chr10:95,373,304...95,490,406 JBrowse link
G Map2k7 mitogen activated protein kinase kinase 7 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of MAP2K7 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MAP2K7 mRNA] CTD PMID:20230807 NCBI chr12:2,591,312...2,604,211 JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases activity
increases phosphorylation
decreases expression
multiple interactions
increases expression
ISO
EXP
Nicotine results in increased activity of MAPK1 protein
Nicotine results in increased phosphorylation of MAPK1 protein
Nicotine results in decreased expression of MAPK1 protein
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of MAPK1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MAPK1 mRNA]
Melatonin inhibits the reaction [Nicotine results in decreased expression of MAPK1 protein]; Melatonin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Nicotine results in increased phosphorylation of and results in increased activity of MAPK1 protein
Nicotine results in increased expression of MAPK1 protein modified form
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Camptothecin co-treated with Nicotine] results in increased phosphorylation of MAPK1 protein; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Nicotine co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased phosphorylation of MAPK1 protein; [Nicotine co-treated with Ethanol] results in increased phosphorylation of MAPK1 protein; [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of FOS protein]; [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of JUN protein]; [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of PTGS2]; [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] which results in decreased susceptibility to Nicotine; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Nicotine results in decreased activity of MAPK1 protein]; Curcumin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Hexamethonium inhibits the reaction [Nicotine results in decreased phosphorylation of MAPK1 protein]; Hexamethonium inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Lobeline inhibits the reaction [Nicotine results in decreased phosphorylation of MAPK1 protein]; Nicotine inhibits the reaction [Cisplatin results in increased activity of MAPK1 protein]; Nicotine inhibits the reaction [Fluorouracil results in increased phosphorylation of MAPK1 protein]; Nicotine inhibits the reaction [Paclitaxel results in increased activity of MAPK1 protein]; Nicotine results in decreased phosphorylation of and results in decreased activity of MAPK1 protein; Nicotine results in increased phosphorylation of and results in increased activity of MAPK1 protein; Propranolol inhibits the reaction [Nicotine results in decreased phosphorylation of MAPK1 protein]; Propranolol inhibits the reaction [Nicotine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Propranolol inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Staurosporine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; TP53 protein affects the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Tubocurarine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Vecuronium Bromide inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]
CTD PMID:12421819 PMID:12460746 PMID:15983034 PMID:17003101 PMID:17459420 PMID:18204935 PMID:18448488 PMID:18676776 PMID:19903766 PMID:20050989 PMID:20106947 PMID:20230807 PMID:20727180 PMID:22119045 PMID:22261521 PMID:24095863 PMID:24201001 PMID:29486207 PMID:30259641 NCBI chr11:83,957,813...84,023,629 JBrowse link
G Mapk11 mitogen-activated protein kinase 11 decreases expression ISO Nicotine results in decreased expression of MAPK11 mRNA CTD PMID:17135361 NCBI chr 7:120,218,471...120,225,488 JBrowse link
G Mapk13 mitogen activated protein kinase 13 decreases expression ISO Nicotine results in decreased expression of MAPK13 mRNA CTD PMID:17135361 NCBI chr20:6,835,277...6,845,500 JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
decreases expression
increases expression
increases activity
decreases activity
ISO
EXP
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [Camptothecin co-treated with Nicotine] results in increased phosphorylation of MAPK3 protein; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [Nicotine co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased phosphorylation of MAPK3 protein; [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of FOS protein]; [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of JUN protein]; [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of PTGS2]; [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] which results in decreased susceptibility to Nicotine; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Nicotine results in decreased activity of MAPK3 protein]; Curcumin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Hexamethonium inhibits the reaction [Nicotine results in decreased phosphorylation of MAPK3 protein]; Hexamethonium inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Lobeline inhibits the reaction [Nicotine results in decreased phosphorylation of MAPK3 protein]; Nicotine inhibits the reaction [Cisplatin results in increased activity of MAPK3 protein]; Nicotine inhibits the reaction [Fluorouracil results in increased phosphorylation of MAPK3 protein]; Nicotine inhibits the reaction [Paclitaxel results in increased activity of MAPK3 protein]; Nicotine results in decreased phosphorylation of and results in decreased activity of MAPK3 protein; Nicotine results in increased phosphorylation of and results in increased activity of MAPK3 protein; Propranolol inhibits the reaction [Nicotine results in decreased phosphorylation of MAPK3 protein]; Propranolol inhibits the reaction [Nicotine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Propranolol inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Staurosporine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; TP53 protein affects the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Tubocurarine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Vecuronium Bromide inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]
Nicotine results in decreased expression of MAPK3 protein
Melatonin inhibits the reaction [Nicotine results in decreased expression of MAPK3 protein]; Melatonin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Nicotine results in increased phosphorylation of and results in increased activity of MAPK3 protein
Nicotine results in decreased expression of MAPK3 mRNA; Nicotine results in decreased expression of MAPK3 protein
Nicotine results in increased expression of MAPK3 protein modified form
Nicotine results in increased activity of MAPK3 protein
CTD PMID:12421819 PMID:12460746 PMID:15983034 PMID:17003101 PMID:17135361 PMID:17459420 PMID:17997037 PMID:18204935 PMID:18448488 PMID:18676776 PMID:19903766 PMID:20050989 PMID:20106947 PMID:20727180 PMID:22119045 PMID:22261521 PMID:24095863 PMID:29486207 PMID:30259641 NCBI chr 1:181,366,646...181,372,863 JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions
increases expression
increases activity
ISO
EXP
Nicotine results in increased phosphorylation of MAPK8 protein
Nicotine promotes the reaction [MAPK8 protein results in increased phosphorylation of JUN protein]
Nicotine results in increased expression of MAPK8 mRNA
Nicotine results in increased activity of MAPK8 protein
Curcumin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK8 protein]; Nicotine inhibits the reaction [Cisplatin results in increased phosphorylation of and results in increased activity of MAPK8 protein]; TP53 protein affects the reaction [Nicotine results in increased phosphorylation of MAPK8 protein]
CTD PMID:11592233 PMID:17021677 PMID:20426880 PMID:20727180 PMID:21511693 NCBI chr16:8,638,897...8,721,960 JBrowse link
G Mapk9 mitogen-activated protein kinase 9 decreases expression EXP Nicotine results in decreased expression of MAPK9 mRNA CTD PMID:26776438 NCBI chr10:34,169,661...34,211,138 JBrowse link
G Mast2 microtubule associated serine/threonine kinase 2 increases expression ISO Nicotine results in increased expression of MAST2 mRNA CTD PMID:33640489 NCBI chr 5:129,776,293...129,915,502 JBrowse link
G Mbp myelin basic protein increases phosphorylation EXP Nicotine results in increased phosphorylation of MBP protein CTD PMID:15983034 NCBI chr18:75,855,878...75,966,404 JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions
increases phosphorylation
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Nicotine results in increased phosphorylation of MCL1 protein]; [Nicotine results in increased phosphorylation of MCL1 protein] which results in increased expression of and results in increased stability of MCL1 protein; Propranolol inhibits the reaction [Nicotine results in increased phosphorylation of MCL1 protein] CTD PMID:19903766 NCBI chr 2:183,219,137...183,235,676 JBrowse link
G Mcmdc2 minichromosome maintenance domain containing 2 increases expression EXP Nicotine results in increased expression of MCMDC2 mRNA CTD PMID:27782041 NCBI chr 5:9,291,967...9,337,526 JBrowse link
G Mctp1 multiple C2 and transmembrane domain containing 1 decreases expression ISO Nicotine results in decreased expression of MCTP1 mRNA CTD PMID:21955143 NCBI chr 2:6,071,408...6,761,833 JBrowse link
G Mdh2 malate dehydrogenase 2 decreases activity
multiple interactions
EXP Nicotine results in decreased activity of MDH2 protein
Folic Acid inhibits the reaction [Nicotine results in decreased activity of MDH2 protein]
CTD PMID:29972271 NCBI chr12:20,894,269...20,907,225 JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions ISO [[Nicotine results in decreased expression of RPS27A protein] which results in increased phosphorylation of MDM2 protein] which results in increased ubiquitination of TP53 protein; [Nicotine results in decreased expression of RPS27A protein] which results in increased phosphorylation of MDM2 protein CTD PMID:30272249 NCBI chr 7:53,290,660...53,315,205 JBrowse link
G Me1 malic enzyme 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ME1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ME1 mRNA] CTD PMID:20230807 NCBI chr 8:87,549,043...87,660,251 JBrowse link
G Med24 mediator complex subunit 24 increases expression ISO Nicotine results in increased expression of MED24 mRNA CTD PMID:23825647 NCBI chr10:83,664,609...83,702,315 JBrowse link
G Med28 mediator complex subunit 28 increases expression ISO Nicotine results in increased expression of MED28 mRNA CTD PMID:16949557 NCBI chr14:65,594,785...65,603,583 JBrowse link
G Mef2c myocyte enhancer factor 2C affects expression EXP Nicotine affects the expression of MEF2C mRNA CTD PMID:20426880 NCBI chr 2:13,973,299...14,136,065 JBrowse link
G Mettl3 methyltransferase-like 3 increases expression ISO Nicotine results in increased expression of METTL3 mRNA CTD PMID:17456735 NCBI chr15:25,002,505...25,014,097 JBrowse link
G Mgp matrix Gla protein multiple interactions EXP [Cholecalciferol co-treated with Nicotine] results in decreased expression of MGP protein CTD PMID:19910445 NCBI chr 4:169,766,290...169,769,612 JBrowse link
G Mir15b microRNA 15b increases methylation
decreases expression
ISO Nicotine results in increased methylation of MIR15B gene
Nicotine results in decreased expression of MIR15B mRNA
CTD PMID:33640489 NCBI chr 2:153,245,200...153,245,297 JBrowse link
G Mir98 microRNA 98 decreases expression
multiple interactions
ISO Nicotine results in decreased expression of MIR98 mRNA
MIR98 mRNA affects the reaction [Nicotine results in increased expression of NGF protein]; MIR98 mRNA inhibits the reaction [Nicotine results in increased expression of EDN1 mRNA]; MIR98 mRNA inhibits the reaction [Nicotine results in increased expression of FN1 mRNA]; Rosiglitazone inhibits the reaction [Nicotine results in decreased expression of MIR98 mRNA]
CTD PMID:33082140 NCBI chr  X:20,981,235...20,981,342 JBrowse link
G Mirlet7b microRNA let-7b decreases expression ISO Nicotine results in decreased expression of MIRLET7B mRNA CTD PMID:33082140 NCBI chr 7:116,804,186...116,804,270 JBrowse link
G Mirlet7d microRNA let-7d decreases expression ISO Nicotine results in decreased expression of MIRLET7D mRNA CTD PMID:33082140 NCBI chr17:16,115,893...16,115,990 JBrowse link
G Mirlet7g microRNA let-7g decreases expression ISO Nicotine results in decreased expression of MIRLET7G mRNA CTD PMID:33082140 NCBI chr 8:106,822,293...106,822,380 JBrowse link
G Mirlet7i microRNA let-7i decreases expression ISO Nicotine results in decreased expression of MIRLET7I mRNA CTD PMID:33082140 NCBI chr 7:58,642,485...58,642,569 JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions
increases expression
decreases expression
EXP [Nicotine co-treated with Butylhydroxybutylnitrosamine] results in increased expression of MKI67 protein; Hexamethonium inhibits the reaction [[Nicotine co-treated with Butylhydroxybutylnitrosamine] results in increased expression of MKI67 protein]; methyllycaconitine inhibits the reaction [[Nicotine co-treated with Butylhydroxybutylnitrosamine] results in increased expression of MKI67 protein]
Nicotine results in increased expression of MKI67 protein
Nicotine results in decreased expression of MKI67 protein
CTD PMID:29501575 PMID:30959089 PMID:31678612 NCBI chr 1:190,496,319...190,522,983 JBrowse link
G Mlph melanophilin increases expression ISO Nicotine results in increased expression of MLPH mRNA CTD PMID:23825647 NCBI chr 9:91,507,410...91,542,984 JBrowse link
G Mme membrane metallo-endopeptidase increases expression ISO Nicotine results in increased expression of MME mRNA CTD PMID:23825647 NCBI chr 2:147,686,913...147,803,808 JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions
increases expression
ISO lipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of MMP1 mRNA]; lipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of MMP1 protein]; Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP1 mRNA]; Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP1 protein]; Polymyxin B inhibits the reaction [lipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of MMP1 protein]]; Polymyxin B inhibits the reaction [Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP1 protein]]; Tubocurarine inhibits the reaction [lipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of MMP1 protein]]; Tubocurarine inhibits the reaction [Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP1 protein]]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of MMP1 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of MMP1 protein]
Nicotine results in increased expression of MMP1 mRNA; Nicotine results in increased expression of MMP1 protein
CTD PMID:17151781 PMID:18986645 NCBI chr 8:4,658,588...4,679,099 JBrowse link
G Mmp13 matrix metallopeptidase 13 increases expression ISO Nicotine results in increased expression of MMP13 mRNA; Nicotine results in increased expression of MMP13 protein CTD PMID:17151781 NCBI chr 8:4,497,960...4,508,239 JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases expression
increases expression
ISO lipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of MMP2 mRNA]; Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP2 mRNA]
[BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of MMP2 mRNA
Nicotine results in decreased expression of MMP2 protein
Nicotine results in increased expression of MMP2 mRNA; Nicotine results in increased expression of MMP2 protein
CTD PMID:14569062 PMID:17151781 PMID:18986645 PMID:20448088 PMID:23825647 PMID:33091441 NCBI chr19:14,154,657...14,182,870 JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions
increases expression
ISO lipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of MMP3 mRNA]; Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP3 mRNA]
Nicotine results in increased expression of MMP3 mRNA; Nicotine results in increased expression of MMP3 protein
CTD PMID:17151781 PMID:18986645 NCBI chr 8:4,640,397...4,653,963 JBrowse link
G Mmp7 matrix metallopeptidase 7 multiple interactions
increases expression
affects response to substance
ISO CREB1 protein promotes the reaction [Nicotine results in increased expression of MMP7 mRNA]; MK-886 inhibits the reaction [Nicotine results in increased expression of MMP7 mRNA]; MMP7 promoter SNP affects the reaction [Nicotine results in increased expression of MMP7 mRNA]
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of MMP7 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MMP7 mRNA]
Nicotine results in increased expression of MMP7 mRNA; Nicotine results in increased expression of MMP7 protein
MMP7 promoter SNP affects the susceptibility to Nicotine
CTD PMID:20061081 PMID:20230807 PMID:25847246 NCBI chr 8:4,848,186...4,855,908 JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression
multiple interactions
decreases expression
ISO Nicotine results in increased expression of MMP9 mRNA; Nicotine results in increased expression of MMP9 protein
MK-886 inhibits the reaction [Nicotine results in increased expression of MMP9 mRNA]
Nicotine results in decreased expression of MMP9 protein
CTD PMID:14569062 PMID:20061081 PMID:20448088 NCBI chr 3:153,684,158...153,692,118 JBrowse link
G Mpo myeloperoxidase decreases activity
increases activity
multiple interactions
EXP Nicotine results in decreased activity of MPO protein
Nicotine results in increased activity of MPO protein
Acetylcysteine inhibits the reaction [Nicotine results in increased activity of MPO protein]; erdosteine inhibits the reaction [Nicotine results in increased activity of MPO protein]; Nicotine inhibits the reaction [Acetic Acid results in increased activity of MPO protein]; Vitamin E inhibits the reaction [Nicotine results in increased activity of MPO protein]
CTD PMID:15976189 PMID:17216608 PMID:23810507 NCBI chr10:72,594,458...72,608,862 JBrowse link
G Mrm3 mitochondrial rRNA methyltransferase 3 decreases expression ISO Nicotine results in decreased expression of MRM3 mRNA CTD PMID:17997037 NCBI chr10:61,095,920...61,125,421 JBrowse link
G Mrpl10 mitochondrial ribosomal protein L10 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of MRPL10 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of MRPL10 mRNA] CTD PMID:20230807 NCBI chr10:82,026,031...82,034,451 JBrowse link
G Mrpl20 mitochondrial ribosomal protein L20 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MRPL20 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of MRPL20 mRNA] CTD PMID:20230807 NCBI chr 5:166,408,962...166,413,492 JBrowse link
G Mrpl41 mitochondrial ribosomal protein L41 decreases expression ISO Nicotine results in decreased expression of MRPL41 mRNA CTD PMID:17997037 NCBI chr 3:7,780,658...7,781,576 JBrowse link
G Mrpl54 mitochondrial ribosomal protein L54 increases expression ISO Nicotine results in increased expression of MRPL54 mRNA CTD PMID:17456735 NCBI chr 7:8,452,801...8,455,321 JBrowse link
G mrpl9 mitochondrial ribosomal protein L9 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MRPL9 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MRPL9 mRNA] CTD PMID:20230807 NCBI chr 2:182,082,012...182,086,758 JBrowse link
G Msmo1 methylsterol monooxygenase 1 increases expression ISO Nicotine results in increased expression of MSMO1 mRNA CTD PMID:23416264 NCBI chr16:24,980,680...24,997,927 JBrowse link
G Mst1 macrophage stimulating 1 decreases expression ISO Nicotine results in decreased expression of MST1 mRNA CTD PMID:18247414 NCBI chr 8:108,767,886...108,773,425 JBrowse link
G Msx1 msh homeobox 1 increases expression EXP Nicotine results in increased expression of MSX1 mRNA CTD PMID:20339300 NCBI chr14:72,961,170...72,964,970 JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I decreases expression EXP Nicotine results in decreased expression of COX1 protein CTD PMID:28681937
G Mt2A metallothionein 2A multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MT2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MT2 mRNA] CTD PMID:20230807 NCBI chr19:10,832,009...10,832,783 JBrowse link
G Mt3 metallothionein 3 multiple interactions ISO [Nicotine co-treated with polylactic acid-polyglycolic acid copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MT3 protein]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MT3 protein] CTD PMID:23933227 NCBI chr19:10,848,754...10,850,158 JBrowse link
G Mtch1 mitochondrial carrier 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of MTCH1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MTCH1 mRNA] CTD PMID:20230807 NCBI chr20:7,389,942...7,413,426 JBrowse link
G Mtf2 metal response element binding transcription factor 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MTF2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MTF2 mRNA] CTD PMID:20230807 NCBI chr14:1,639,256...1,683,513 JBrowse link
G Mtif2 mitochondrial translational initiation factor 2 increases expression ISO Nicotine results in increased expression of MTIF2 mRNA CTD PMID:16949557 NCBI chr14:103,265,808...103,285,733 JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases expression
multiple interactions
increases phosphorylation
EXP
ISO
Nicotine results in decreased expression of MTOR mRNA
Nicotine promotes the reaction [Dextran Sulfate results in decreased phosphorylation of MTOR protein]
dorsomorphin inhibits the reaction [Nicotine promotes the reaction [Dextran Sulfate results in decreased phosphorylation of MTOR protein]]; Nicotine promotes the reaction [Dextran Sulfate results in decreased phosphorylation of MTOR protein]
Nicotine results in increased phosphorylation of MTOR protein
CTD PMID:26776438 PMID:30836163 PMID:31926917 NCBI chr 5:158,884,856...158,994,311 JBrowse link
G