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Gene: E2f1 (E2F transcription factor 1) Rattus norvegicus
Symbol: E2f1
Name: E2F transcription factor 1
RGD ID: 728892
Description: Exhibits protein kinase binding activity and sequence-specific DNA binding activity. Involved in several processes, including cellular response to hypoxia; cellular response to nerve growth factor stimulus; and positive regulation of glial cell proliferation. Localizes to cytoplasm and nucleus. Biomarker of Huntington's disease and pancreatic cancer. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; lung small cell carcinoma; lung squamous cell carcinoma; pancreatic adenocarcinoma; and pancreatic ductal adenocarcinoma. Orthologous to human E2F1 (E2F transcription factor 1); PARTICIPATES IN cell cycle pathway, mitotic; ceramide signaling pathway; chronic myeloid leukemia pathway; INTERACTS WITH (-)-citrinin; (-)-epigallocatechin 3-gallate; 1-naphthyl isothiocyanate.
Type: protein-coding
Also known as: E2F-1; transcription factor E2F1
Homo sapiens (human) : E2F1 (E2F transcription factor 1)  HGNC  Alliance
Mus musculus (house mouse) : E2f1 (E2F transcription factor 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : E2f1 (E2F transcription factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : E2F1 (E2F transcription factor 1)
Canis lupus familiaris (dog) : E2F1 (E2F transcription factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : E2f1 (E2F transcription factor 1)
Sus scrofa (pig) : E2F1 (E2F transcription factor 1)
Chlorocebus sabaeus (African green monkey) : E2F1 (E2F transcription factor 1)
Heterocephalus glaber (naked mole-rat) : E2f1 (E2F transcription factor 1)
more info ...
Is Marker For: Strains:   SD  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.03150,062,895 - 150,073,721 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3150,047,826 - 150,073,721 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03156,435,530 - 156,446,390 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43145,032,489 - 145,043,729 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13144,943,133 - 144,943,246 (-)NCBI
Celera3141,799,009 - 141,809,945 (-)NCBICelera
Cytogenetic Map3q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on E2f1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 728892
Created: 2003-11-21
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.