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Gene: E2f1 (E2F transcription factor 1) Rattus norvegicus
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Symbol: E2f1
Name: E2F transcription factor 1
Description: Exhibits protein kinase binding activity and sequence-specific DNA binding activity. Involved in several processes, including cellular response to hypoxia; cellular response to nerve growth factor stimulus; and positive regulation of glial cell proliferation. Localizes to the cytoplasm and nucleus. Biomarker of Huntington's disease and pancreatic cancer. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; lung small cell carcinoma; lung squamous cell carcinoma; pancreatic adenocarcinoma; and pancreatic ductal adenocarcinoma. Orthologous to human E2F1 (E2F transcription factor 1); PARTICIPATES IN cell cycle pathway, mitotic; ceramide signaling pathway; chronic myeloid leukemia pathway; INTERACTS WITH (-)-citrinin; 1-naphthyl isothiocyanate; 2-acetamidofluorene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: E2F-1; transcription factor E2F1
Orthologs:
Homo sapiens (human) : E2F1 (E2F transcription factor 1)  HGNC  Alliance
Mus musculus (house mouse) : E2f1 (E2F transcription factor 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : E2f1 (E2F transcription factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : E2F1 (E2F transcription factor 1)
Canis lupus familiaris (dog) : E2F1 (E2F transcription factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : E2f1 (E2F transcription factor 1)
Sus scrofa (pig) : E2F1 (E2F transcription factor 1)
more info ...
Is Marker For: Strains:   SD  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.03150,062,895 - 150,073,721 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3150,047,826 - 150,073,721 (-)Ensembl
Rnor_5.03156,435,530 - 156,446,390 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43145,032,489 - 145,043,729 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13144,943,133 - 144,943,246 (-)NCBI
Celera3141,799,009 - 141,809,945 (-)NCBICelera
Cytogenetic Map3q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on E2f1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 728892
Created: 2003-11-21
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.