Btg1 (BTG anti-proliferation factor 1) - Rat Genome Database

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Gene: Btg1 (BTG anti-proliferation factor 1) Rattus norvegicus
Analyze
Symbol: Btg1
Name: BTG anti-proliferation factor 1
RGD ID: 2224
Description: Predicted to enable enzyme binding activity. Involved in response to oxidative stress; response to peptide hormone; and spermatogenesis. Predicted to be active in cytoplasm and nucleus. Biomarker of protein-energy malnutrition. Orthologous to human BTG1 (BTG anti-proliferation factor 1); PARTICIPATES IN RNA degradation pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: anti-proliferative factor; B-cell translocation gene 1; B-cell translocation gene 1 anti-proliferative; B-cell translocation gene 1, anti-proliferative
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8733,228,149 - 33,230,406 (+)NCBIGRCr8
mRatBN7.2731,341,391 - 31,343,649 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl731,341,027 - 31,343,649 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx733,328,264 - 33,330,526 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0735,476,327 - 35,478,590 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0735,250,810 - 35,253,072 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0737,812,831 - 37,815,088 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl737,812,831 - 37,815,088 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0737,858,321 - 37,860,578 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4734,029,300 - 34,031,557 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1734,049,570 - 34,051,828 (+)NCBI
Celera728,389,620 - 28,391,877 (+)NCBICelera
Cytogenetic Map7q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-schisandrin B  (EXP)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(E)-thiamethoxam  (ISO)
(S)-amphetamine  (ISO)
(S)-colchicine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-Nitrobenzanthrone  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (EXP,ISO)
acrylamide  (ISO)
adenine  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
Ampullosporin  (EXP)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
buta-1,3-diene  (ISO)
butyric acid  (EXP)
calcitriol  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
celastrol  (ISO)
chloropicrin  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloromethane  (ISO)
diclofenac  (ISO)
dieldrin  (EXP)
diethylstilbestrol  (ISO)
diuron  (ISO)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
ethyl methanesulfonate  (ISO)
ethylbenzene  (ISO)
fipronil  (EXP)
fluoranthene  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
gedunin  (ISO)
genistein  (ISO)
gentamycin  (EXP)
indometacin  (ISO)
isoflavones  (ISO)
ketamine  (EXP)
levofloxacin  (EXP)
lipopolysaccharide  (ISO)
malathion  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
miconazole  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N(6)-dimethylallyladenine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
nefazodone  (EXP)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nimesulide  (EXP)
o-xylene  (ISO)
ochratoxin A  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium chromate  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
succimer  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thiamethoxam  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
toluene  (ISO)
trichloroethene  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO,ISS)
nucleus  (IBA,ISO,ISS)

Molecular Function
enzyme binding  (ISO,ISS)
protein binding  (IPI,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Interaction of PRMT1 with BTG/TOB proteins in cell signalling: molecular analysis and functional aspects. Berthet C, etal., Genes Cells 2002 Jan;7(1):29-39.
2. Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1. Bogdan JA, etal., Biochem J. 1998 Dec 1;336 ( Pt 2):471-81.
3. Identification of B-cell translocation gene 1 as a biomarker for monitoring the remission of acute myeloid leukemia. Cho JW, etal., Proteomics 2004 Nov;4(11):3456-63.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Cloning of rat Sertoli cell follicle-stimulating hormone primary response complementary deoxyribonucleic acid: regulation of TSC-22 gene expression. Hamil KG and Hall SH, Endocrinology 1994 Mar;134(3):1205-12.
6. Identification of genes enhanced by protein-calorie malnutrition by differential display polymerase chain reaction (expression of fibrinogen B beta chain, B cell translocation gene 1 and thyroid hormone responsive protein genes). Lee AK, etal., Mol Cell Biochem 2002 Feb;231(1-2):163-71.
7. Mitogen-stimulated TIS21 protein interacts with a protein-kinase-Calpha-binding protein rPICK1. Lin WJ, etal., Biochem J 2001 Mar 15;354(Pt 3):635-43.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. Stage-specific expression of B cell translocation gene 1 in rat testis. Raburn DJ, etal., Endocrinology 1995 Dec;136(12):5769-77.
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
15. Transcriptomic analysis of an in vitro murine model of ovarian carcinoma: functional similarity to the human disease and identification of prospective tumoral markers and targets. Urzua U, etal., J Cell Physiol. 2006 Mar;206(3):594-602.
Additional References at PubMed
PMID:1373383   PMID:8663146   PMID:9690562   PMID:11420681   PMID:14734530   PMID:15033446   PMID:19359386   PMID:37062247  


Genomics

Comparative Map Data
Btg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8733,228,149 - 33,230,406 (+)NCBIGRCr8
mRatBN7.2731,341,391 - 31,343,649 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl731,341,027 - 31,343,649 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx733,328,264 - 33,330,526 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0735,476,327 - 35,478,590 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0735,250,810 - 35,253,072 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0737,812,831 - 37,815,088 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl737,812,831 - 37,815,088 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0737,858,321 - 37,860,578 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4734,029,300 - 34,031,557 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1734,049,570 - 34,051,828 (+)NCBI
Celera728,389,620 - 28,391,877 (+)NCBICelera
Cytogenetic Map7q13NCBI
BTG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381292,140,278 - 92,145,846 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1292,140,278 - 92,145,846 (-)EnsemblGRCh38hg38GRCh38
GRCh371292,534,054 - 92,539,622 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361291,061,030 - 91,063,751 (-)NCBINCBI36Build 36hg18NCBI36
Build 341291,039,370 - 91,042,088NCBI
Celera1292,205,336 - 92,210,955 (-)NCBICelera
Cytogenetic Map12q21.33NCBI
HuRef1289,601,434 - 89,607,055 (-)NCBIHuRef
CHM1_11292,499,080 - 92,504,699 (-)NCBICHM1_1
T2T-CHM13v2.01292,117,840 - 92,123,409 (-)NCBIT2T-CHM13v2.0
Btg1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391096,452,863 - 96,458,675 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1096,452,868 - 96,458,671 (+)EnsemblGRCm39 Ensembl
GRCm381096,617,001 - 96,622,813 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1096,617,006 - 96,622,809 (+)EnsemblGRCm38mm10GRCm38
MGSCv371096,079,635 - 96,085,447 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361096,046,715 - 96,049,315 (+)NCBIMGSCv36mm8
MGSCv361096,842,504 - 96,845,104 (+)NCBIMGSCv36mm8
Celera1098,590,586 - 98,596,526 (+)NCBICelera
Cytogenetic Map10C3NCBI
cM Map1049.89NCBI
Btg1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540529,206,889 - 29,209,407 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540529,206,889 - 29,209,407 (-)NCBIChiLan1.0ChiLan1.0
BTG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210100,178,213 - 100,181,864 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112100,174,606 - 100,177,333 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01289,678,431 - 89,681,177 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11292,991,624 - 92,994,379 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1292,992,584 - 92,994,038 (-)Ensemblpanpan1.1panPan2
BTG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11532,646,520 - 32,648,222 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1532,647,472 - 32,647,762 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1533,100,004 - 33,102,594 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01533,316,253 - 33,318,881 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1533,316,256 - 33,318,872 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11532,596,147 - 32,598,738 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01532,659,203 - 32,661,790 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01532,948,922 - 32,951,509 (-)NCBIUU_Cfam_GSD_1.0
Btg1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494527,438,189 - 27,445,484 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365078,789,952 - 8,797,247 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BTG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl590,815,202 - 90,817,142 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1590,815,194 - 90,817,936 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2595,088,441 - 95,091,187 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BTG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11187,553,779 - 87,556,535 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1187,554,731 - 87,556,542 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037157,620,806 - 157,624,624 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Btg1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475014,526,384 - 14,533,049 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475014,526,750 - 14,529,336 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Btg1
10 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:337
Count of miRNA genes:213
Interacting mature miRNAs:239
Transcripts:ENSRNOT00000005910
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354644Spl4Serum phospholipid level QTL 44.9blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)71965431749753746Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
1354637Scl30Serum cholesterol level QTL 303.7blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)71965431749753746Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73111283276112832Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
1354639Spl5Serum phospholipid level QTL 53.9blood LDL phospholipid amount (VT:0010505)blood low density lipoprotein phospholipid level (CMO:0001568)71965431752888450Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
10755451Coatc11Coat color QTL 110coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)71794435762944357Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)71700459862004598Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72673740163902784Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
61369Mcs2Mammary carcinoma susceptibility QTL 23.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)71903280735526300Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)72940968353612950Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)72940968374409683Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71557388960573889Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000005910   ⟹   ENSRNOP00000005910
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl731,341,027 - 31,343,649 (+)Ensembl
Rnor_6.0 Ensembl737,812,831 - 37,815,088 (+)Ensembl
RefSeq Acc Id: NM_017258   ⟹   NP_058954
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8733,228,149 - 33,230,406 (+)NCBI
mRatBN7.2731,341,391 - 31,343,649 (+)NCBI
Rnor_6.0737,812,831 - 37,815,088 (+)NCBI
Rnor_5.0737,858,321 - 37,860,578 (+)NCBI
RGSC_v3.4734,029,300 - 34,031,557 (+)RGD
Celera728,389,620 - 28,391,877 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_058954 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA85779 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000005910.3
  ENSRNOP00055007377
  ENSRNOP00060006287
  ENSRNOP00065015089
GenBank Protein Q63073 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058954   ⟸   NM_017258
- UniProtKB: Q63073 (UniProtKB/Swiss-Prot),   A6IG55 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000005910   ⟸   ENSRNOT00000005910
Protein Domains
Anti-proliferative protein

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63073-F1-model_v2 AlphaFold Q63073 1-171 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2224 AgrOrtholog
BIND 130433
BioCyc Gene G2FUF-34302 BioCyc
Ensembl Genes ENSRNOG00000004284 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055005912 UniProtKB/Swiss-Prot
  ENSRNOG00060005050 UniProtKB/Swiss-Prot
  ENSRNOG00065012107 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000005910.5 UniProtKB/Swiss-Prot
  ENSRNOT00055009565 UniProtKB/Swiss-Prot
  ENSRNOT00060008395 UniProtKB/Swiss-Prot
  ENSRNOT00065019669 UniProtKB/Swiss-Prot
Gene3D-CATH 3.90.640.90 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Anti_prolifrtn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BTG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BTG-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29618 UniProtKB/Swiss-Prot
NCBI Gene 29618 ENTREZGENE
PANTHER B-CELL TRANSLOCATION GENE UniProtKB/TrEMBL
  PROTEIN BTG1 UniProtKB/TrEMBL
  PTHR22978 UniProtKB/Swiss-Prot
  PTHR22978:SF30 UniProtKB/Swiss-Prot
Pfam BTG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Btg1 PhenoGen
PRINTS ANTIPRLFBTG1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE BTG_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BTG_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004284 RatGTEx
  ENSRNOG00055005912 RatGTEx
  ENSRNOG00060005050 RatGTEx
  ENSRNOG00065012107 RatGTEx
SMART btg1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP BTG domain-like UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
TIGR TC217164
UniProt A6IG55 ENTREZGENE, UniProtKB/TrEMBL
  BTG1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-13 Btg1  BTG anti-proliferation factor 1  Btg1  B-cell translocation gene 1, anti-proliferative  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Btg1  B-cell translocation gene 1, anti-proliferative    B-cell translocation gene 1  Name updated 1299863 APPROVED
2002-06-10 Btg1  B-cell translocation gene 1      Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in liver 631316
gene_expression expressed in late primary spermatocytes 631316
gene_expression high level of expression seen at entry into terminal spermatid differentiation 631316
gene_product member of a new family of putative antiproliferative factors 631316
gene_regulation expression is increased by oxidative stress due to protein-calorie malnutrition 631316