Pcsk1 (proprotein convertase subtilisin/kexin type 1) - Rat Genome Database

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Gene: Pcsk1 (proprotein convertase subtilisin/kexin type 1) Rattus norvegicus
Analyze
Symbol: Pcsk1
Name: proprotein convertase subtilisin/kexin type 1
RGD ID: 3272
Description: Enables endopeptidase activity. Involved in several processes, including nervous system development; protein processing; and response to interleukin-1. Located in several cellular components, including perikaryon; perinuclear region of cytoplasm; and trans-Golgi network. Used to study hyperglycemia and type 2 diabetes mellitus. Biomarker of glucose metabolism disease (multiple); hyperthyroidism; hypothyroidism; islet cell tumor; and visual epilepsy. Human ortholog(s) of this gene implicated in obesity and proprotein convertase 1/3 deficiency. Orthologous to human PCSK1 (proprotein convertase subtilisin/kexin type 1); PARTICIPATES IN altered energy homeostasis pathway; altered melanocortin system pathway; melanocortin system pathway; INTERACTS WITH (+)-pilocarpine; 1,2-dimethylhydrazine; 1,3-dinitrobenzene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BDP; NEC 1; neuroendocrine convertase 1; PC1; PC3; prohormone convertase 1; prohormone convertase 3; proprotein convertase 1; Protein convertase subtilisin / kexin type I; Protein convertase subtilisin / kexin, type I
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr826,130,045 - 6,176,974 (+)NCBIGRCr8
mRatBN7.224,395,543 - 4,442,434 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl24,395,543 - 4,442,434 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx211,498,001 - 11,544,940 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.029,597,257 - 9,644,196 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.024,240,758 - 4,287,694 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0291,450,162 - 91,497,091 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl291,450,162 - 91,497,091 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.022,274,882 - 2,309,886 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.421,923,309 - 1,970,238 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.121,937,434 - 1,981,975 (+)NCBI
Celera2885,989 - 932,918 (+)NCBICelera
Cytogenetic Map2q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,3-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
CGP 52608  (ISO)
chloroprene  (EXP)
cisplatin  (EXP)
clothianidin  (ISO)
cocaine  (EXP)
Cuprizon  (EXP)
decabromodiphenyl ether  (EXP)
diarsenic trioxide  (ISO)
dioxygen  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gatifloxacin  (ISO)
glycidol  (EXP)
glyphosate  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
mercury dibromide  (ISO)
methamphetamine  (EXP)
methimazole  (EXP)
methoxychlor  (EXP)
N,N-diethyl-m-toluamide  (EXP)
nickel atom  (ISO)
p-chloromercuribenzoic acid  (ISO)
perfluorooctanoic acid  (EXP)
permethrin  (EXP)
phenylmercury acetate  (ISO)
resveratrol  (EXP)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
silicon dioxide  (ISO)
Soman  (EXP)
streptozocin  (EXP)
sulforaphane  (ISO)
temozolomide  (ISO)
thioacetamide  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of non-insulin-dependent diabetes mellitus. Alarcon C, etal., J Clin Invest. 1995 Mar;95(3):1032-9.
2. Colocalization of chaperone Cpn60, proinsulin and convertase PC1 within immature secretory granules of insulin-secreting cells suggests a role for Cpn60 in insulin processing. Arias AE, etal., J Cell Sci. 2000 Jun;113 ( Pt 11):2075-83.
3. Regulation of the biosynthesis and processing of chromogranins in organotypic slices: influence of depolarization, forskolin and differentiating factors. Bauer R, etal., Eur J Neurosci. 2000 Aug;12(8):2746-56.
4. Immunohistochemical expression and colocalization of somatostatin, carboxypeptidase-E and prohormone convertases 1 and 2 in rat brain. Billova S, etal., Neuroscience. 2007 Jun 29;147(2):403-18. Epub 2007 Jun 1.
5. Prohormone-converting enzymes: regulation and evaluation of function using antisense RNA. Bloomquist BT, etal., Mol Endocrinol 1991 Dec;5(12):2014-24.
6. Altered proinsulin conversion in rat pancreatic islets exposed long-term to various glucose concentrations or interleukin-1beta. Borjesson A and Carlsson C, J Endocrinol. 2007 Feb;192(2):381-7.
7. Distribution and colocalization of cholecystokinin with the prohormone convertase enzymes PC1, PC2, and PC5 in rat brain. Cain BM, etal., J Comp Neurol 2003 Dec 15;467(3):307-25.
8. Dietary sodium modulates mRNA abundance of enzymes involved in pituitary processing of proopiomelanocortin. Chandramohan G, etal., Pituitary. 2001 Sep;4(4):231-7.
9. Docosahexaenoic acid significantly stimulates immediate early response genes and neurite outgrowth. Dagai L, etal., Neurochem Res. 2009 May;34(5):867-75. Epub 2008 Sep 10.
10. Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic beta cell via two distinct site-specific endopeptidases. Davidson HW, etal., Nature. 1988 May 5;333(6168):93-6. doi: 10.1038/333093a0.
11. Gene expression of proprotein convertases in individual rat anterior pituitary cells and their regulation in corticotrophs mediated by glucocorticoids. Dong W and Day R, Endocrinology 2002 Jan;143(1):254-62.
12. Cellular colocalization and coregulation between hypothalamic pro-TRH and prohormone convertases in hypothyroidism. Espinosa VP, etal., Am J Physiol Endocrinol Metab. 2007 Jan;292(1):E175-86. Epub 2006 Aug 22.
13. Differential regulation of prohormone convertase 1/3, prohormone convertase 2 and phosphorylated cyclic-AMP-response element binding protein by short-term and long-term morphine treatment: implications for understanding the "switch" to opiate addiction. Espinosa VP, etal., Neuroscience. 2008 Oct 15;156(3):788-99. Epub 2008 Aug 9.
14. Adult rat liver cells transdifferentiated with lentiviral IPF1 vectors reverse diabetes in mice: an ex vivo gene therapy approach. Fodor A, etal., Diabetologia. 2007 Jan;50(1):121-30. Epub 2006 Nov 28.
15. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
16. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
17. Proinsulin processing in the diabetic Goto-Kakizaki rat. Guest PC, etal., J Endocrinol. 2002 Dec;175(3):637-47.
18. Gene expression alterations of neurotrophins, their receptors and prohormone convertases in a rat model of spinal cord contusion. Hajebrahimi Z, etal., Neurosci Lett. 2008 Aug 29;441(3):261-6. Epub 2008 Jun 21.
19. Isolation of two complementary deoxyribonucleic acid clones from a rat insulinoma cell line based on similarities to Kex2 and furin sequences and the specific localization of each transcript to endocrine and neuroendocrine tissues in rats. Hakes DJ, etal., Endocrinology 1991 Dec;129(6):3053-63.
20. Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene. Jackson RS, etal., Nat Genet. 1997 Jul;16(3):303-6.
21. Gene expression patterns of pro-opiomelanocortin-processing enzymes PC1 and PC2 during postnatal development of rat corticotrophs. Kato H, etal., J Histochem Cytochem. 2004 Jul;52(7):943-57.
22. Lipopolysaccharide mediated regulation of neuroendocrine associated proprotein convertases and neuropeptide precursor processing in the rat spleen. Lansac G, etal., J Neuroimmunol. 2006 Feb;171(1-2):57-71. Epub 2005 Dec 5.
23. Developmental expression of proprotein convertase 1/3 in the rat. Lee YC, etal., Mol Cell Endocrinol. 1999 Sep 10;155(1-2):27-35.
24. Prohormone convertases 1 and 2 process ProPACAP and generate matured, bioactive PACAP38 and PACAP27 in transfected rat pituitary GH4C1 cells. Li M, etal., Neuroendocrinology. 1999 Mar;69(3):217-26.
25. Regulation of prohormone convertase 1 (PC1) by gp130-related cytokines. Li QL, etal., Mol Cell Endocrinol. 1999 Dec 20;158(1-2):143-52.
26. The identification of potential factors associated with the development of type 2 diabetes: a quantitative proteomics approach. Lu H, etal., Mol Cell Proteomics. 2008 Aug;7(8):1434-51. Epub 2008 Apr 30.
27. B Lymphocytes Express Pomc mRNA, Processing Enzymes and β-Endorphin in Painful Inflammation. Maddila SC, etal., J Neuroimmune Pharmacol. 2017 Mar;12(1):180-186. doi: 10.1007/s11481-016-9715-4. Epub 2016 Nov 11.
28. Electron microscopic immunocytochemical evidence for the involvement of the convertases PC1 and PC2 in the processing of proinsulin in pancreatic beta-cells. Malide D, etal., J Histochem Cytochem. 1995 Jan;43(1):11-9.
29. Developmental expression of the prohormone convertases PC1 and PC2 in mouse pancreatic islets. Marcinkiewicz M, etal., Endocrinology. 1994 Oct;135(4):1651-60.
30. Pilocarpine-induced seizures are accompanied by a transient elevation in the messenger RNA expression of the prohormone convertase PC1 in rat hippocampus: comparison with nerve growth factor and brain-derived neurotrophic factor expression. Marcinkiewicz M, etal., Neuroscience. 1997 Jan;76(2):425-39.
31. Adenovirally encoded prohormone convertase-1 functions in atrial myocyte large dense core vesicles. Marx R and Mains RE, Endocrinology. 1997 Dec;138(12):5108-18.
32. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
33. Subcellular pathways of beta-endorphin synthesis, processing, and release from immunocytes in inflammatory pain. Mousa SA, etal., Endocrinology. 2004 Mar;145(3):1331-41. Epub 2003 Nov 20.
34. Immunocytochemical localization of the prohormone convertases PC1 and PC2 in rat prolactin cells. Muller L, etal., J Histochem Cytochem. 1998 Jan;46(1):101-8.
35. Up-regulation of splenic prohormone convertases PC1 and PC2 in diabetic rats. Nakashima M, etal., Regul Pept. 2001 Dec 15;102(2-3):135-45.
36. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
37. Precursor-protein convertase 1 gene expression in the mouse hypothalamus: differential regulation by ob gene mutation, energy deficit and administration of leptin, and coexpression with prepro-orexin. Nilaweera KN, etal., Neuroscience. 2003;119(3):713-20.
38. Regulation of prohormone convertases in hypothalamic neurons: implications for prothyrotropin-releasing hormone and proopiomelanocortin. Nillni EA Endocrinology. 2007 Sep;148(9):4191-200. Epub 2007 Jun 21.
39. Extracellular matrix proteins increase the expression of pro-TRH and pro-protein convertase PC1 in fetal hypothalamic neurons in vitro. Niquet J, etal., Brain Res Dev Brain Res. 2000 Mar 15;120(1):49-56.
40. Human prohormone convertase 3 gene: exon-intron organization and molecular scanning for mutations in Japanese subjects with NIDDM. Ohagi S, etal., Diabetes. 1996 Jul;45(7):897-901.
41. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
42. How the hindgut can cure type 2 diabetes. Ileal transposition improves glucose metabolism and beta-cell function in Goto-kakizaki rats through an enhanced Proglucagon gene expression and L-cell number. Patriti A, etal., Surgery. 2007 Jul;142(1):74-85.
43. Thyroid hormones selectively regulate the posttranslational processing of prothyrotropin-releasing hormone in the paraventricular nucleus of the hypothalamus. Perello M, etal., Endocrinology. 2006 Jun;147(6):2705-16. Epub 2006 Feb 23.
44. Pro-opiomelanocortin processing in the hypothalamus: impact on melanocortin signalling and obesity. Pritchard LE, etal., J Endocrinol 2002 Mar;172(3):411-21.
45. GOA pipeline RGD automated data pipeline
46. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
47. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
48. Preferential cleavage of des-31,32-proinsulin over intact proinsulin by the insulin secretory granule type II endopeptidase. Implication of a favored route for prohormone processing. Rhodes CJ, etal., J Biol Chem. 1992 Nov 15;267(32):22719-27.
49. Altered control of the hypothalamo-pituitary-adrenal axis in adult male rats exposed perinatally to food deprivation and/or dehydration. Sebaai N, etal., Neuroendocrinology. 2002 Oct;76(4):243-53.
50. The critical role of the melanocortin system in the control of energy balance. Seeley RJ, etal., Annu Rev Nutr 2004;24:133-49.
51. Thyroid hormone regulation of prohormone convertase 1 (PC1): regional expression in rat brain and in vitro characterization of negative thyroid hormone response elements. Shen X, etal., J Mol Endocrinol. 2004 Aug;33(1):21-33.
52. Mutational analysis of predicted interactions between the catalytic and P domains of prohormone convertase 3 (PC3/PC1). Ueda K, etal., Proc Natl Acad Sci U S A 2003 May 13;100(10):5622-7.
53. MAFA controls genes implicated in insulin biosynthesis and secretion. Wang H, etal., Diabetologia. 2007 Feb;50(2):348-58. Epub 2006 Dec 6.
54. Paired box 6 (PAX6) regulates glucose metabolism via proinsulin processing mediated by prohormone convertase 1/3 (PC1/3). Wen JH, etal., Diabetologia. 2009 Mar;52(3):504-13. Epub 2008 Nov 26.
55. A switch from prohormone convertase (PC)-2 to PC1/3 expression in transplanted alpha-cells is accompanied by differential processing of proglucagon and improved glucose homeostasis in mice. Wideman RD, etal., Diabetes. 2007 Nov;56(11):2744-52. Epub 2007 Aug 13.
56. Transplantation of PC1/3-Expressing alpha-cells improves glucose handling and cold tolerance in leptin-resistant mice. Wideman RD, etal., Mol Ther. 2009 Jan;17(1):191-8. Epub 2008 Oct 21.
57. Improving function and survival of pancreatic islets by endogenous production of glucagon-like peptide 1 (GLP-1). Wideman RD, etal., Proc Natl Acad Sci U S A. 2006 Sep 5;103(36):13468-73. Epub 2006 Aug 28.
58. Regional and cellular localization of the neuroendocrine prohormone convertases PC1 and PC2 in the rat central nervous system. Winsky-Sommerer R, etal., J Comp Neurol. 2000 Aug 28;424(3):439-60.
59. Regulation of pancreatic endocrine cell differentiation by sulphated proteoglycans. Zertal-Zidani S, etal., Diabetologia. 2007 Mar;50(3):585-95. Epub 2007 Jan 13.
60. The developmental expression in rat of proteases furin, PC1, PC2, and carboxypeptidase E: implications for early maturation of proteolytic processing capacity. Zheng M, etal., J Neurosci. 1994 Aug;14(8):4656-73.
61. Regulatory roles of the P domain of the subtilisin-like prohormone convertases. Zhou A, etal., J Biol Chem. 1998 May 1;273(18):11107-14.
62. Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects. Zhu X, etal., Proc Natl Acad Sci U S A 2002 Aug 6;99(16):10293-8. Epub 2002 Jul 26.
Additional References at PubMed
PMID:8262946   PMID:8397508   PMID:9242664   PMID:15146101   PMID:15286802   PMID:16204236   PMID:16221685   PMID:16274843   PMID:16384863   PMID:16476726   PMID:17240044   PMID:17531155  
PMID:17556096   PMID:18784614   PMID:19376969   PMID:19628676   PMID:23050949   PMID:23637853   PMID:26778167  


Genomics

Comparative Map Data
Pcsk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr826,130,045 - 6,176,974 (+)NCBIGRCr8
mRatBN7.224,395,543 - 4,442,434 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl24,395,543 - 4,442,434 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx211,498,001 - 11,544,940 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.029,597,257 - 9,644,196 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.024,240,758 - 4,287,694 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0291,450,162 - 91,497,091 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl291,450,162 - 91,497,091 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.022,274,882 - 2,309,886 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.421,923,309 - 1,970,238 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.121,937,434 - 1,981,975 (+)NCBI
Celera2885,989 - 932,918 (+)NCBICelera
Cytogenetic Map2q11NCBI
PCSK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38596,390,333 - 96,433,248 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl596,390,333 - 96,434,143 (-)EnsemblGRCh38hg38GRCh38
GRCh37595,726,037 - 95,768,952 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36595,751,875 - 95,794,708 (-)NCBINCBI36Build 36hg18NCBI36
Build 34595,751,874 - 95,794,708NCBI
Celera591,608,060 - 91,651,008 (-)NCBICelera
Cytogenetic Map5q15NCBI
HuRef590,916,038 - 90,958,959 (-)NCBIHuRef
CHM1_1595,158,671 - 95,201,600 (-)NCBICHM1_1
T2T-CHM13v2.0596,891,318 - 96,934,221 (-)NCBIT2T-CHM13v2.0
Pcsk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391375,237,407 - 75,282,980 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1375,237,945 - 75,282,980 (+)EnsemblGRCm39 Ensembl
GRCm381375,089,420 - 75,134,861 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1375,089,826 - 75,134,861 (+)EnsemblGRCm38mm10GRCm38
MGSCv371375,227,435 - 75,269,946 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361375,555,989 - 75,598,500 (+)NCBIMGSCv36mm8
Celera1377,413,324 - 77,455,835 (+)NCBICelera
Cytogenetic Map13C1NCBI
cM Map1340.63NCBI
Pcsk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541816,181,771 - 16,224,603 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541816,181,809 - 16,224,274 (+)NCBIChiLan1.0ChiLan1.0
PCSK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2418,947,427 - 18,989,920 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1517,101,051 - 17,143,521 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0518,917,488 - 18,960,102 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1519,064,004 - 19,106,486 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl519,064,004 - 19,106,486 (+)Ensemblpanpan1.1panPan2
PCSK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1313,233,342 - 13,276,921 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl313,233,594 - 13,274,094 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha314,573,263 - 14,616,624 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0313,112,863 - 13,155,997 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl313,112,897 - 13,155,993 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1313,076,913 - 13,120,227 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0313,073,463 - 13,116,776 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0313,272,840 - 13,316,211 (+)NCBIUU_Cfam_GSD_1.0
Pcsk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213168,824,505 - 168,864,179 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365237,010,068 - 7,050,468 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365237,009,966 - 7,050,300 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PCSK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2103,004,794 - 103,050,839 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12103,004,794 - 103,050,707 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Pig Cytomap2qNCBI
PCSK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1490,246,413 - 90,289,148 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl490,248,598 - 90,289,089 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604938,898,564 - 38,941,574 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pcsk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474314,994,172 - 15,036,412 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474314,993,436 - 15,036,512 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pcsk1
43 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:240
Count of miRNA genes:160
Interacting mature miRNAs:184
Transcripts:ENSRNOT00000015185
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2141244106Rat
631682Bp115Blood pressure QTL 1154.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2137410502Rat

Markers in Region
M58589  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.224,439,925 - 4,440,044 (-)MAPPERmRatBN7.2
Rnor_6.0291,452,552 - 91,452,670NCBIRnor6.0
Rnor_5.022,307,378 - 2,307,496UniSTSRnor5.0
Rnor_5.02111,213,493 - 111,213,611UniSTSRnor5.0
RGSC_v3.421,967,730 - 1,967,848UniSTSRGSC3.4
Celera2930,410 - 930,528UniSTS
Cytogenetic Map2q11-q12UniSTS
AU049217  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.224,431,894 - 4,432,100 (-)MAPPERmRatBN7.2
Rnor_6.0291,460,496 - 91,460,701NCBIRnor6.0
Rnor_5.022,299,347 - 2,299,552UniSTSRnor5.0
Rnor_5.02111,221,437 - 111,221,642UniSTSRnor5.0
RGSC_v3.421,959,699 - 1,959,904UniSTSRGSC3.4
Celera2922,379 - 922,584UniSTS
Cytogenetic Map2q11-q12UniSTS
BE119208  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.224,439,827 - 4,439,977 (-)MAPPERmRatBN7.2
Rnor_6.0291,452,619 - 91,452,768NCBIRnor6.0
Rnor_5.022,307,280 - 2,307,429UniSTSRnor5.0
Rnor_5.02111,213,560 - 111,213,709UniSTSRnor5.0
RGSC_v3.421,967,632 - 1,967,781UniSTSRGSC3.4
Celera2930,312 - 930,461UniSTS
Cytogenetic Map2q11-q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
8 3 7 111 61 60 32 22 32 6 102 51 91 10 29 28

Sequence


Ensembl Acc Id: ENSRNOT00000015185   ⟹   ENSRNOP00000015185
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl24,395,543 - 4,442,434 (+)Ensembl
Rnor_6.0 Ensembl291,450,162 - 91,497,091 (-)Ensembl
RefSeq Acc Id: NM_017091   ⟹   NP_058787
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr826,130,045 - 6,176,974 (+)NCBI
mRatBN7.224,395,543 - 4,442,434 (+)NCBI
Rnor_6.0291,450,162 - 91,497,091 (-)NCBI
Rnor_5.022,274,882 - 2,309,886 (+)NCBI
RGSC_v3.421,923,309 - 1,970,238 (+)RGD
Celera2885,989 - 932,918 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_058787 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40945 (Get FASTA)   NCBI Sequence Viewer  
  AAA41476 (Get FASTA)   NCBI Sequence Viewer  
  EDM09905 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000015185.2
  ENSRNOP00055000113
  ENSRNOP00060002939
  ENSRNOP00065006385
GenBank Protein P28840 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058787   ⟸   NM_017091
- Peptide Label: precursor
- UniProtKB: P28840 (UniProtKB/Swiss-Prot),   A6I4E7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015185   ⟸   ENSRNOT00000015185
Protein Domains
P/Homo B   Peptidase S8

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P28840-F1-model_v2 AlphaFold P28840 1-752 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691229
Promoter ID:EPDNEW_R1752
Type:single initiation site
Name:Pcsk1_1
Description:proprotein convertase subtilisin/kexin type 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0291,497,093 - 91,497,153EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3272 AgrOrtholog
BioCyc Gene G2FUF-55111 BioCyc
Ensembl Genes ENSRNOG00000011107 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055000110 UniProtKB/Swiss-Prot
  ENSRNOG00060002599 UniProtKB/Swiss-Prot
  ENSRNOG00065005946 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015185.4 UniProtKB/Swiss-Prot
  ENSRNOT00055000174 UniProtKB/Swiss-Prot
  ENSRNOT00060004168 UniProtKB/Swiss-Prot
  ENSRNOT00065008967 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.70.850 UniProtKB/Swiss-Prot
  3.40.50.200 UniProtKB/Swiss-Prot
  6.10.250.3320 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Galactose-binding domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase S8, pro-domain UniProtKB/TrEMBL
  Peptidase S8/S53 domain UniProtKB/TrEMBL
InterPro Galactose-bd-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kexin/furin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S8/S53_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S8/S53_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S8_Asp-AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S8_His-AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S8_Ser-AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S8_subtilisin-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Proho_convert UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S8_pro-domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S8_pro-domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25204 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25204 ENTREZGENE
PANTHER NEUROENDOCRINE CONVERTASE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam P_proprotein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Proho_convert UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S8_pro-domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pcsk1 PhenoGen
PRINTS SUBTILISIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE P_HOMO_B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUBTILASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUBTILASE_ASP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUBTILASE_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUBTILASE_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011107 RatGTEx
  ENSRNOG00055000110 RatGTEx
  ENSRNOG00060002599 RatGTEx
  ENSRNOG00065005946 RatGTEx
Superfamily-SCOP Galactose-binding domain-like UniProtKB/TrEMBL
  Protease propeptides/inhibitors UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49785 UniProtKB/Swiss-Prot
  SSF52743 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6I4E7 ENTREZGENE, UniProtKB/TrEMBL
  NEC1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Pcsk1  Protein convertase subtilisin / kexin, type I      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in endocrine and neuroendocrine tissues 70278
gene_process has a role in the maturation of mammalian hormones 70278
gene_process may function in secretory pathway 70278
gene_product 752 aa protein 70278