Gene: Pcsk1 (proprotein convertase subtilisin/kexin type 1) Rattus norvegicus
Symbol: Pcsk1
Name: proprotein convertase subtilisin/kexin type 1
Description: ENCODES a protein that exhibits chaperone binding; endopeptidase activity; insulin binding; INVOLVED IN neurogenesis; pancreas development; peptide hormone processing; PARTICIPATES IN altered energy homeostasis pathway; altered melanocortin system pathway; melanocortin system pathway; ASSOCIATED WITH Adenoma, Islet Cell; Dehydration; diabetes mellitus, experimental; FOUND IN axon terminus; dendrite; extracellular space; INTERACTS WITH (+)-pilocarpine; 1,2-dimethylhydrazine; 1,3-dinitrobenzene
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: BDP; NEC 1; neuroendocrine convertase 1; PC1; PC3; prohormone convertase 1; prohormone convertase 3; proprotein convertase 1; Protein convertase subtilisin / kexin type I; Protein convertase subtilisin / kexin, type I
Homo sapiens (human) : PCSK1 (proprotein convertase subtilisin/kexin type 1)  HGNC  Alliance
Mus musculus (house mouse) : Pcsk1 (proprotein convertase subtilisin/kexin type 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pcsk1 (proprotein convertase subtilisin/kexin type 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PCSK1 (proprotein convertase subtilisin/kexin type 1)
Canis lupus familiaris (dog) : PCSK1 (proprotein convertase subtilisin/kexin type 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pcsk1 (proprotein convertase subtilisin/kexin type 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0291,450,162 - 91,497,091 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.022,274,882 - 2,309,886 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.421,923,309 - 1,970,238 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.121,937,434 - 1,981,975 (+)NCBI
Celera2885,989 - 932,918 (+)NCBICelera
Cytogenetic Map2q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Pcsk1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3272
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2018-03-20
Status: ACTIVE