Prox1 (prospero homeobox 1) - Rat Genome Database

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Gene: Prox1 (prospero homeobox 1) Rattus norvegicus
Analyze
Symbol: Prox1
Name: prospero homeobox 1
RGD ID: 1306890
Description: Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein domain specific binding activity. Involved in liver development and response to nutrient levels. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Biomarker of status epilepticus. Orthologous to human PROX1 (prospero homeobox 1); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: prospero homeobox protein 1; prospero-related homeobox 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr813104,196,615 - 104,251,007 (-)NCBIGRCr8
mRatBN7.213101,669,184 - 101,719,804 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl13101,669,184 - 101,711,183 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx13104,184,132 - 104,234,742 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.013105,573,270 - 105,623,873 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.013102,780,918 - 102,831,509 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013108,382,536 - 108,444,107 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13108,382,399 - 108,443,294 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013113,004,568 - 113,064,606 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413106,421,541 - 106,471,350 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.113106,611,772 - 106,660,015 (-)NCBI
Celera13101,149,597 - 101,200,064 (-)NCBICelera
Cytogenetic Map13q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amiodarone  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (EXP)
caffeine  (ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
dextran sulfate  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
flutamide  (EXP)
glyphosate  (EXP)
hydrogen cyanide  (ISO)
hydrogen peroxide  (ISO)
isoprenaline  (ISO)
leflunomide  (ISO)
menaquinone  (ISO)
methapyrilene  (EXP)
methylmercury chloride  (ISO)
nicotine  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenformin  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium cyanide  (ISO)
propiconazole  (ISO)
Ptaquiloside  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
senecionine  (ISO)
silicon dioxide  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acinar cell differentiation  (ISO)
aorta smooth muscle tissue morphogenesis  (ISO)
atrial cardiac muscle tissue morphogenesis  (ISO)
blood vessel endothelial cell differentiation  (ISO)
brain development  (ISO)
branching involved in pancreas morphogenesis  (ISO)
cell population proliferation  (ISO)
cerebellar granule cell differentiation  (ISO)
circadian rhythm  (ISO)
dentate gyrus development  (ISO)
embryonic retina morphogenesis in camera-type eye  (ISO)
endocardium formation  (ISO)
epithelial cell migration  (ISO)
hepatocyte cell migration  (ISO)
hepatocyte differentiation  (ISO)
hepatocyte proliferation  (ISO)
inner ear development  (ISO)
kidney development  (ISO)
lens development in camera-type eye  (ISO)
lens fiber cell morphogenesis  (ISO)
lens morphogenesis in camera-type eye  (ISO)
lens placode formation involved in camera-type eye formation  (ISO)
liver development  (IEP,ISO)
lung development  (ISO)
lymph vessel development  (ISO)
lymphangiogenesis  (ISO)
lymphatic endothelial cell differentiation  (ISO)
lymphatic endothelial cell fate commitment  (ISO)
negative regulation of bile acid biosynthetic process  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of DNA-binding transcription factor activity  (IEA,ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of neuroblast proliferation  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of viral genome replication  (ISO)
neuroblast proliferation  (ISO)
neuron fate determination  (ISO)
neuronal stem cell population maintenance  (ISO)
pancreas development  (ISO)
positive regulation of cell cycle  (ISO)
positive regulation of cell cycle checkpoint  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cyclin-dependent protein serine/threonine kinase activity  (IEA,ISO)
positive regulation of endothelial cell migration  (ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of forebrain neuron differentiation  (ISO)
positive regulation of heart growth  (ISO)
positive regulation of neural precursor cell proliferation  (ISO)
positive regulation of sarcomere organization  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
regulation of circadian rhythm  (ISO)
regulation of gene expression  (ISO)
regulation of transcription by RNA polymerase II  (IBA)
response to nutrient levels  (IEP)
skeletal muscle thin filament assembly  (ISO)
transcription by RNA polymerase II  (ISO)
venous blood vessel morphogenesis  (ISO)
ventricular cardiac muscle tissue morphogenesis  (ISO)
ventricular cardiac myofibril assembly  (ISO)
ventricular septum morphogenesis  (ISO)

Cellular Component
cytoplasm  (ISO)
cytosol  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Prospero-related homeobox 1 (Prox1) is a stable hepatocyte marker during liver development, injury and regeneration, and is absent from "oval cells". Dudas J, etal., Histochem Cell Biol. 2006 Nov;126(5):549-62. Epub 2006 Jun 13.
2. A prospero-related homeobox gene Prox-1 is expressed during postnatal brain development as well as in the adult rodent brain. Galeeva A, etal., Neuroscience. 2007 May 11;146(2):604-16. Epub 2007 Mar 26.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Triiodothyronine accelerates differentiation of rat liver progenitor cells into hepatocytes. Laszlo V, etal., Histochem Cell Biol. 2008 Nov;130(5):1005-14. Epub 2008 Jul 29.
6. Stereological methods reveal the robust size and stability of ectopic hilar granule cells after pilocarpine-induced status epilepticus in the adult rat. McCloskey DP, etal., Eur J Neurosci. 2006 Oct;24(8):2203-10. Epub 2006 Oct 17.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. Maternal diet programs embryonic kidney gene expression. Welham SJ, etal., Physiol Genomics. 2005 Jun 16;22(1):48-56. Epub 2005 Apr 12.
Additional References at PubMed
PMID:8812486   PMID:10080188   PMID:10888866   PMID:11789987   PMID:11850194   PMID:11927535   PMID:12198161   PMID:12412020   PMID:12692551   PMID:15143342   PMID:15205472   PMID:15232737  
PMID:16170315   PMID:16291864   PMID:16488887   PMID:17062673   PMID:17828556   PMID:18815287   PMID:19023449   PMID:19056883   PMID:19091769   PMID:19210544   PMID:19264593   PMID:19901262  
PMID:20186345   PMID:20808958   PMID:21040746   PMID:21300049   PMID:22178591   PMID:23723244   PMID:27731315   PMID:34495369  


Genomics

Comparative Map Data
Prox1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr813104,196,615 - 104,251,007 (-)NCBIGRCr8
mRatBN7.213101,669,184 - 101,719,804 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl13101,669,184 - 101,711,183 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx13104,184,132 - 104,234,742 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.013105,573,270 - 105,623,873 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.013102,780,918 - 102,831,509 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013108,382,536 - 108,444,107 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13108,382,399 - 108,443,294 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013113,004,568 - 113,064,606 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413106,421,541 - 106,471,350 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.113106,611,772 - 106,660,015 (-)NCBI
Celera13101,149,597 - 101,200,064 (-)NCBICelera
Cytogenetic Map13q26NCBI
PROX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381213,983,151 - 214,041,510 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1213,983,181 - 214,041,510 (+)EnsemblGRCh38hg38GRCh38
GRCh371214,161,316 - 214,214,853 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361212,228,483 - 212,276,389 (+)NCBINCBI36Build 36hg18NCBI36
Build 341210,550,254 - 210,598,155NCBI
Celera1187,384,890 - 187,432,754 (+)NCBICelera
Cytogenetic Map1q32.3NCBI
HuRef1184,835,849 - 184,890,058 (+)NCBIHuRef
CHM1_11215,433,762 - 215,487,303 (+)NCBICHM1_1
T2T-CHM13v2.01213,222,727 - 213,281,050 (+)NCBIT2T-CHM13v2.0
Prox1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391189,850,232 - 189,903,024 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1189,850,232 - 189,902,911 (-)EnsemblGRCm39 Ensembl
GRCm381190,118,035 - 190,170,827 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1190,118,035 - 190,170,714 (-)EnsemblGRCm38mm10GRCm38
MGSCv371191,945,654 - 191,994,559 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361191,822,563 - 191,871,468 (-)NCBIMGSCv36mm8
Celera1197,032,975 - 197,082,606 (-)NCBICelera
Cytogenetic Map1H6NCBI
cM Map195.85NCBI
Prox1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554063,719,972 - 3,770,555 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554063,715,140 - 3,770,019 (-)NCBIChiLan1.0ChiLan1.0
PROX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2135,361,029 - 35,413,818 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1135,325,338 - 35,378,134 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01189,556,124 - 189,609,297 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11194,412,980 - 194,466,170 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1194,412,980 - 194,460,763 (+)Ensemblpanpan1.1panPan2
PROX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1711,996,282 - 12,047,693 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl711,996,703 - 12,044,036 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha711,570,534 - 11,623,681 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0711,705,650 - 11,758,863 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl711,705,620 - 11,755,413 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1711,629,931 - 11,683,010 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0711,734,165 - 11,787,370 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0711,858,013 - 11,911,782 (+)NCBIUU_Cfam_GSD_1.0
Prox1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934462,175,888 - 62,230,044 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366284,185,706 - 4,238,451 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366284,185,712 - 4,240,680 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PROX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9129,532,184 - 129,580,982 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19129,527,704 - 129,583,693 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29142,424,393 - 142,480,770 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PROX1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12515,533,546 - 15,592,834 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2515,538,964 - 15,587,059 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605516,013,948 - 16,067,368 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prox1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477119,196,366 - 19,233,338 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477119,188,543 - 19,238,621 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Prox1
146 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:287
Count of miRNA genes:173
Interacting mature miRNAs:221
Transcripts:ENSRNOT00000004905
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat

Markers in Region
D13Rat162  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.213101,707,556 - 101,707,799 (-)MAPPERmRatBN7.2
Rnor_6.013108,394,664 - 108,394,906NCBIRnor6.0
Rnor_5.013113,016,428 - 113,016,670UniSTSRnor5.0
RGSC_v3.413106,459,162 - 106,459,405RGDRGSC3.4
RGSC_v3.413106,459,163 - 106,459,405UniSTSRGSC3.4
RGSC_v3.113106,648,266 - 106,648,509RGD
Celera13101,187,887 - 101,188,129UniSTS
FHH x ACI Map1360.0699RGD
FHH x ACI Map1360.0699UniSTS
Cytogenetic Map13q27UniSTS
BG373964  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.213101,698,456 - 101,698,564 (-)MAPPERmRatBN7.2
Rnor_6.013108,403,822 - 108,403,929NCBIRnor6.0
Rnor_5.013113,025,586 - 113,025,693UniSTSRnor5.0
RGSC_v3.413106,450,011 - 106,450,118UniSTSRGSC3.4
Celera13101,178,801 - 101,178,908UniSTS
RH 3.4 Map13697.1UniSTS
Cytogenetic Map13q27UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000004905   ⟹   ENSRNOP00000004905
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl13101,669,184 - 101,711,183 (-)Ensembl
Rnor_6.0 Ensembl13108,382,399 - 108,443,294 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096982   ⟹   ENSRNOP00000088774
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl13101,669,184 - 101,710,934 (-)Ensembl
RefSeq Acc Id: NM_001107201   ⟹   NP_001100671
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813104,200,378 - 104,250,975 (-)NCBI
mRatBN7.213101,669,184 - 101,719,804 (-)NCBI
Rnor_6.013108,382,662 - 108,440,346 (+)NCBI
Rnor_5.013113,004,568 - 113,064,606 (+)NCBI
RGSC_v3.413106,421,541 - 106,471,350 (-)RGD
Celera13101,149,597 - 101,200,064 (-)RGD
Sequence:
RefSeq Acc Id: XM_063272391   ⟹   XP_063128461
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813104,196,615 - 104,250,303 (-)NCBI
RefSeq Acc Id: XM_063272392   ⟹   XP_063128462
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813104,196,615 - 104,250,530 (-)NCBI
RefSeq Acc Id: XM_063272393   ⟹   XP_063128463
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813104,196,615 - 104,249,445 (-)NCBI
RefSeq Acc Id: XM_063272394   ⟹   XP_063128464
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813104,196,615 - 104,251,007 (-)NCBI
RefSeq Acc Id: XM_063272395   ⟹   XP_063128465
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813104,196,615 - 104,251,007 (-)NCBI
RefSeq Acc Id: XM_063272396   ⟹   XP_063128466
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813104,196,615 - 104,242,420 (-)NCBI
RefSeq Acc Id: NP_001100671   ⟸   NM_001107201
- Sequence:
Ensembl Acc Id: ENSRNOP00000004905   ⟸   ENSRNOT00000004905
Ensembl Acc Id: ENSRNOP00000088774   ⟸   ENSRNOT00000096982
RefSeq Acc Id: XP_063128465   ⟸   XM_063272395
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063128464   ⟸   XM_063272394
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063128462   ⟸   XM_063272392
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063128461   ⟸   XM_063272391
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063128463   ⟸   XM_063272393
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063128466   ⟸   XM_063272396
- Peptide Label: isoform X3
Protein Domains
Prospero

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZU00-F1-model_v2 AlphaFold D3ZU00 1-654 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699105
Promoter ID:EPDNEW_R9630
Type:multiple initiation site
Name:Prox1_1
Description:prospero homeobox 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.013108,382,661 - 108,382,721EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306890 AgrOrtholog
BioCyc Gene G2FUF-16894 BioCyc
Ensembl Genes ENSRNOG00000003694 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004905.6 UniProtKB/TrEMBL
  ENSRNOT00000096982.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.500 UniProtKB/TrEMBL
InterPro Homeo_prospero_dom UniProtKB/TrEMBL
  Homeo_prospero_dom_sf UniProtKB/TrEMBL
  Homeodomain-like UniProtKB/TrEMBL
  Prospero_homeodomain UniProtKB/TrEMBL
KEGG Report rno:305066 UniProtKB/TrEMBL
NCBI Gene 305066 ENTREZGENE
PANTHER PTHR12198 UniProtKB/TrEMBL
  PTHR12198:SF6 UniProtKB/TrEMBL
Pfam HPD UniProtKB/TrEMBL
PhenoGen Prox1 PhenoGen
PROSITE HOMEO_PROSPERO UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003694 RatGTEx
Superfamily-SCOP SSF46689 UniProtKB/TrEMBL
UniProt A0A8I6A8R7 ENTREZGENE, UniProtKB/TrEMBL
  A6JGW7_RAT UniProtKB/TrEMBL
  D3ZU00 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-24 Prox1  prospero homeobox 1  Prox1  prospero-related homeobox 1   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Prox1  prospero-related homeobox 1   Prox1_predicted  prospero-related homeobox 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Prox1_predicted  prospero-related homeobox 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED