Gene: Sox18 (SRY-box transcription factor 18) Rattus norvegicus
Analyze
Symbol:
Sox18
Name:
SRY-box transcription factor 18
Description:
Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II proximal promoter sequence-specific DNA binding activity; and protein heterodimerization activity. Predicted to be involved in several processes, including circulatory system development; mRNA transcription by RNA polymerase II; and regulation of transcription by RNA polymerase II. Predicted to localize to the nuclear chromatin and nuclear transcription factor complex. Orthologous to human SOX18 (SRY-box transcription factor 18); INTERACTS WITH 6-propyl-2-thiouracil; benzo[a]pyrene; bisphenol A.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
LOC311723; SRY (sex determining region Y)-box 18; SRY box 18; SRY-box containing gene 18; transcription factor SOX-18
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
SOX18 (SRY-box transcription factor 18) HGNC
Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB
Mus musculus (house mouse):
Sox18 (SRY (sex determining region Y)-box 18) HGNC
OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Sox18 (SRY-box transcription factor 18) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
SOX18 (SRY-box transcription factor 18) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Sox18 (SRY-box transcription factor 18) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
SOX18 (SRY-box transcription factor 18) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
SOX17 (SRY-box transcription factor 17) HGNC
OrthoDB
Homo sapiens (human):
SOX7 (SRY-box transcription factor 7) HGNC
OrthoDB
Alliance orthologs 3
Homo sapiens (human):
SOX18 (SRY-box transcription factor 18)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Mus musculus (house mouse):
Sox18 (SRY (sex determining region Y)-box 18)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Danio rerio (zebrafish):
sox18 (SRY (sex determining region Y)-box 18)
Alliance
DIOPT (Ensembl Compara, InParanoid, OMA, OrthoFinder, PANTHER)
Drosophila melanogaster (fruit fly):
Sox15
Alliance
DIOPT (Ensembl Compara, OrthoFinder, OrthoInspector, PANTHER)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 3 177,177,237 - 177,179,039 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 3 177,177,310 - 177,179,127 (-) Ensembl Rnor_5.0 3 180,885,768 - 180,887,570 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 3 170,820,460 - 170,822,262 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 3 170,726,497 - 170,728,298 (-) NCBI Celera 3 163,800,470 - 163,802,272 (+) NCBI Celera Cytogenetic Map 3 q43 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
hypotrichosis-lymphedema-telangiectasia syndrome ISO RGD:1323321 8554872 ClinVar Annotator: match by term: Hypotrichosis-lymphedema-telangiectasia syndrome ClinVar PMID:12740761 more ... hypotrichosis-lymphedema-telangiectasia syndrome ISO RGD:1323321 8554872 ClinVar Annotator: match by OMIM:607823 ClinVar PMID:11701398 , PMID:12740761 hypotrichosis-lymphedema-telangiectasia syndrome ISO RGD:1323321 8554872 ClinVar Annotator: match by OMIM:607823 ClinVar PMID:12740761 hypotrichosis-lymphedema-telangiectasia syndrome ISO RGD:1323321 8554872 ClinVar Annotator: match by OMIM:607823 ClinVar PMID:12740761 more ... hypotrichosis-lymphedema-telangiectasia-renal defect syndrome ISO RGD:1323321 8554872 ClinVar Annotator: match by term: Glomerulonephritis with sparse hair and telangiectases ClinVar PMID:12740761 more ... hypotrichosis-lymphedema-telangiectasia-renal defect syndrome ISO RGD:1323321 8554872 ClinVar Annotator: match by term: Glomerulonephritis with sparse hair and telangiectases ClinVar PMID:25741868 , PMID:29307792
Imported Annotations - CTD
Arsenic Poisoning ISO RGD:1323321 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16835338 Glomerulonephritis with Sparse Hair and Telangiectases ISO RGD:1323321 11554173 CTD Direct Evidence: marker/mechanism CTD skin disease ISO RGD:1323321 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16835338 Imported Annotations - OMIM
hypotrichosis-lymphedema-telangiectasia syndrome ISO RGD:1323321 7240710 OMIM hypotrichosis-lymphedema-telangiectasia-renal defect syndrome ISO RGD:1323321 7240710 OMIM
(+)-catechin multiple interactions ISO RGD:1323321 6480464 [Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of SOX18 mRNA CTD PMID:24763279 (S)-nicotine decreases expression ISO RGD:1323322 6480464 Nicotine results in decreased expression of SOX18 mRNA CTD PMID:17456735 17beta-estradiol decreases expression ISO RGD:1323321 6480464 Estradiol results in decreased expression of SOX18 mRNA CTD PMID:20106945 17beta-estradiol affects expression ISO RGD:1323322 6480464 Estradiol affects the expression of SOX18 mRNA CTD PMID:15598610 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1323322 6480464 Tetrachlorodibenzodioxin affects the expression of SOX18 mRNA CTD PMID:24058054 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1323321 6480464 [Tetrachlorodibenzodioxin co-treated with 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide] results in decreased expression of SOX18 mRNA CTD PMID:29704546 3,4-methylenedioxymethamphetamine decreases expression ISO RGD:1323322 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of SOX18 mRNA CTD PMID:26251327 4,4'-diaminodiphenylmethane increases expression ISO RGD:1323322 6480464 4, 4'-diaminodiphenylmethane results in increased expression of SOX18 mRNA CTD PMID:18648102 4,4'-sulfonyldiphenol increases expression ISO RGD:1323322 6480464 bis(4-hydroxyphenyl)sulfone results in increased expression of SOX18 mRNA CTD PMID:30951980 4-hydroxyphenyl retinamide decreases expression ISO RGD:1323322 6480464 Fenretinide results in decreased expression of SOX18 mRNA CTD PMID:16467112 4-hydroxyphenyl retinamide increases expression ISO RGD:1323322 6480464 Fenretinide results in increased expression of SOX18 mRNA CTD PMID:28973697 5-aza-2'-deoxycytidine affects expression ISO RGD:1323321 6480464 Decitabine affects the expression of SOX18 mRNA CTD PMID:23300844 5-fluorouracil affects response to substance ISO RGD:1323321 6480464 SOX18 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of SOX18 mRNA CTD PMID:25825206 Aroclor 1254 increases expression ISO RGD:1323321 6480464 Chlorodiphenyl (54% Chlorine) results in increased expression of SOX18 mRNA CTD PMID:16934159 arsane decreases expression ISO RGD:1323321 6480464 Arsenic results in decreased expression of SOX18 mRNA CTD PMID:16835338 arsenic atom decreases expression ISO RGD:1323321 6480464 Arsenic results in decreased expression of SOX18 mRNA CTD PMID:16835338 arsenous acid decreases expression ISO RGD:1323321 6480464 Arsenic Trioxide results in decreased expression of SOX18 mRNA CTD PMID:15761015 benzene increases expression ISO RGD:1323322 6480464 Benzene results in increased expression of SOX18 mRNA CTD PMID:15120971 , PMID:15122651 benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of SOX18 mRNA CTD PMID:21839799 benzo[a]pyrene decreases expression ISO RGD:1323322 6480464 Benzo(a)pyrene results in decreased expression of SOX18 mRNA CTD PMID:27195522 benzo[a]pyrene increases expression ISO RGD:1323322 6480464 Benzo(a)pyrene results in increased expression of SOX18 mRNA CTD PMID:22228805 benzo[b]fluoranthene increases expression ISO RGD:1323322 6480464 benzo(b)fluoranthene results in increased expression of SOX18 mRNA CTD PMID:26377693 bisphenol A decreases expression ISO RGD:1323322 6480464 bisphenol A results in decreased expression of SOX18 mRNA CTD PMID:26063408 bisphenol A increases methylation ISO RGD:1323322 6480464 bisphenol A results in increased methylation of SOX18 promoter CTD PMID:27312807 bisphenol A affects methylation ISO RGD:1323322 6480464 bisphenol A affects the methylation of SOX18 promoter CTD PMID:27334623 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of SOX18 mRNA CTD PMID:25181051 bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with Testosterone] results in increased expression of SOX18 mRNA CTD PMID:26496021 bisphenol F increases expression ISO RGD:1323322 6480464 bisphenol F results in increased expression of SOX18 mRNA CTD PMID:30951980 C60 fullerene increases expression EXP 6480464 fullerene C60 results in increased expression of SOX18 mRNA CTD PMID:19167457 cadmium atom increases expression ISO RGD:1323321 6480464 Cadmium results in increased expression of SOX18 mRNA CTD PMID:24376830 carbon nanotube decreases expression ISO RGD:1323322 6480464 Nanotubes, Carbon analog results in decreased expression of SOX18 mRNA, Nanotubes, Carbon results in decreased expression of SOX18 mRNA CTD PMID:25554681 , PMID:25620056 carbon nanotube increases expression ISO RGD:1323322 6480464 Nanotubes, Carbon results in increased expression of SOX18 mRNA CTD PMID:25620056 chlorpyrifos increases expression EXP 6480464 Chlorpyrifos results in increased expression of SOX18 mRNA CTD PMID:20691718 choline multiple interactions ISO RGD:1323322 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SOX18 gene CTD PMID:20938992 ciguatoxin CTX1B affects expression ISO RGD:1323322 6480464 Ciguatoxins affects the expression of SOX18 mRNA CTD PMID:18353800 cisplatin affects expression ISO RGD:1323321 6480464 Cisplatin affects the expression of SOX18 mRNA CTD PMID:23300844 clofibrate decreases expression ISO RGD:1323322 6480464 Clofibrate results in decreased expression of SOX18 mRNA CTD PMID:17585979 cyclosporin A decreases expression ISO RGD:1323321 6480464 Cyclosporine results in decreased expression of SOX18 mRNA CTD PMID:21632981 diarsenic trioxide decreases expression ISO RGD:1323321 6480464 Arsenic Trioxide results in decreased expression of SOX18 mRNA CTD PMID:15761015 dibutyl phthalate decreases expression ISO RGD:1323322 6480464 Dibutyl Phthalate results in decreased expression of SOX18 mRNA CTD PMID:17361019 dicrotophos increases expression ISO RGD:1323321 6480464 dicrotophos results in increased expression of SOX18 mRNA CTD PMID:28302478 dioxygen multiple interactions ISO RGD:1323322 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of SOX18 mRNA CTD PMID:30529165 folic acid multiple interactions ISO RGD:1323322 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SOX18 gene CTD PMID:20938992 glycidol increases expression EXP 6480464 glycidol results in increased expression of SOX18 mRNA CTD PMID:24915197 graphite affects expression EXP 6480464 Graphite affects the expression of SOX18 mRNA CTD PMID:29933104 GW 4064 increases expression ISO RGD:1323322 6480464 GW 4064 results in increased expression of SOX18 mRNA CTD PMID:26655953 hydrogen peroxide decreases expression ISO RGD:1323321 6480464 Hydrogen Peroxide results in decreased expression of SOX18 mRNA CTD PMID:15761015 indometacin increases expression ISO RGD:1323321 6480464 Indomethacin results in increased expression of SOX18 mRNA CTD PMID:16984733 L-methionine multiple interactions ISO RGD:1323322 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SOX18 gene CTD PMID:20938992 lead diacetate decreases expression EXP 6480464 lead acetate results in decreased expression of SOX18 mRNA CTD PMID:22641619 mercury atom increases expression ISO RGD:1323321 6480464 Mercury results in increased expression of SOX18 mRNA CTD PMID:16823088 mercury(0) increases expression ISO RGD:1323321 6480464 Mercury results in increased expression of SOX18 mRNA CTD PMID:16823088 methamphetamine multiple interactions EXP 6480464 [Methamphetamine co-treated with SCH 23390] results in decreased expression of SOX18 mRNA CTD PMID:19564919 methamphetamine decreases expression EXP 6480464 Methamphetamine results in decreased expression of SOX18 mRNA CTD PMID:19564919 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal decreases expression ISO RGD:1323322 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of SOX18 mRNA CTD PMID:25566086 nickel dichloride decreases expression ISO RGD:1323321 6480464 nickel chloride results in decreased expression of SOX18 mRNA CTD PMID:17312168 nicotine decreases expression ISO RGD:1323322 6480464 Nicotine results in decreased expression of SOX18 mRNA CTD PMID:17456735 orphenadrine affects expression EXP 6480464 Orphenadrine affects the expression of SOX18 mRNA CTD PMID:23665939 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of SOX18 mRNA CTD PMID:25729387 oxaliplatin increases expression EXP 6480464 oxaliplatin results in increased expression of SOX18 mRNA CTD PMID:25729387 paracetamol increases expression ISO RGD:1323322 6480464 Acetaminophen results in increased expression of SOX18 mRNA CTD PMID:17585979 phosgene affects expression ISO RGD:1323322 6480464 Phosgene affects the expression of SOX18 mRNA CTD PMID:16300373 reactive oxygen species affects expression ISO RGD:1323321 6480464 Reactive Oxygen Species affects the expression of SOX18 mRNA CTD PMID:15761015 rotenone increases expression EXP 6480464 Rotenone results in increased expression of SOX18 mRNA CTD PMID:19013527 SCH 23390 multiple interactions EXP 6480464 [Methamphetamine co-treated with SCH 23390] results in decreased expression of SOX18 mRNA CTD PMID:19564919 silicon dioxide decreases expression EXP 6480464 Silicon Dioxide results in decreased expression of SOX18 mRNA CTD PMID:22431001 Soman decreases expression EXP 6480464 Soman results in decreased expression of SOX18 mRNA CTD PMID:19281266 testosterone multiple interactions EXP 6480464 [bisphenol A co-treated with Testosterone] results in increased expression of SOX18 mRNA CTD PMID:26496021 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of SOX18 mRNA CTD PMID:31150632 thapsigargin decreases expression ISO RGD:1323321 6480464 Thapsigargin results in decreased expression of SOX18 mRNA CTD PMID:29453283 thimerosal decreases expression ISO RGD:1323322 6480464 Thimerosal results in decreased expression of SOX18 mRNA CTD PMID:24675092 titanium dioxide decreases expression ISO RGD:1323322 6480464 titanium dioxide results in decreased expression of SOX18 mRNA CTD PMID:23557971 toluene increases expression EXP 6480464 Toluene results in increased expression of SOX18 mRNA CTD PMID:22967744 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of SOX18 mRNA CTD PMID:25729387 trichloroethene increases expression ISO RGD:1323322 6480464 Trichloroethylene results in increased expression of SOX18 mRNA CTD PMID:19448997 triclosan decreases expression ISO RGD:1323321 6480464 Triclosan results in decreased expression of SOX18 mRNA CTD PMID:30510588 tunicamycin decreases expression ISO RGD:1323321 6480464 Tunicamycin results in decreased expression of SOX18 mRNA CTD PMID:29453283 urethane decreases expression ISO RGD:1323321 6480464 Urethane results in decreased expression of SOX18 mRNA CTD PMID:28818685 valproic acid affects expression ISO RGD:1323322 6480464 Valproic Acid affects the expression of SOX18 mRNA CTD PMID:17292431 valproic acid decreases expression EXP 6480464 Valproic Acid results in decreased expression of SOX18 mRNA CTD PMID:29427782 vinclozolin affects expression EXP 6480464 vinclozolin affects the expression of SOX18 mRNA CTD PMID:19015723
Biological Process anatomical structure morphogenesis IBA FB:FBgn0000411 more ... 13792537 PMID:21873635 GO_Central angiogenesis ISO RGD:1323321 1624291 (PMID:16882943) RGD PMID:16882943 angiogenesis IBA MGI:MGI:103559 more ... 13792537 PMID:21873635 GO_Central angiogenesis ISO RGD:1323322 1624291 MGI:MGI:2178809 more ... RGD MGI:MGI:3664528 , PMID:16895970 biological_process ND 1598407 1/2007: no relevant rat data RGD blood vessel development ISO RGD:1323322 1624291 MGI:MGI:1856135 more ... RGD MGI:MGI:1355042 more ... blood vessel endothelial cell migration ISO RGD:1323321 1624291 (PMID:16882943) RGD PMID:16882943 blood vessel endothelial cell migration IEA UniProtKB:P35713 , ensembl:ENSP000003418151600115 GO_REF:0000107 Ensembl GO_REF:0000107 cell differentiation IBA MGI:MGI:103559 more ... 13792537 PMID:21873635 GO_Central cell differentiation IBA MGI:MGI:98363 , PANTHER:PTN000030384 13792537 PMID:21873635 GO_Central cell maturation ISO RGD:1323322 1624291 (MGI:MGI:4453910, PMID:20228271) RGD MGI:MGI:4453910 , PMID:20228271 cell maturation IEA UniProtKB:P43680 , ensembl:ENSMUSP000000627591600115 GO_REF:0000107 Ensembl GO_REF:0000107 embryonic heart tube development ISO RGD:1323322 1624291 MGI:MGI:107543 (MGI:MGI:3716256 , PMID:17610846) RGD MGI:MGI:3716256 , PMID:17610846 embryonic heart tube development IEA UniProtKB:P43680 , ensembl:ENSMUSP000000627591600115 GO_REF:0000107 Ensembl GO_REF:0000107 endocardial cell differentiation ISO RGD:1323322 1624291 MGI:MGI:107543 (MGI:MGI:3716256 , PMID:17610846) RGD MGI:MGI:3716256 , PMID:17610846 endocardial cell differentiation IEA UniProtKB:P43680 , ensembl:ENSMUSP000000627591600115 GO_REF:0000107 Ensembl GO_REF:0000107 endocardium formation ISO RGD:1323322 1624291 MGI:MGI:107543 (MGI:MGI:3716256 , PMID:17610846) RGD MGI:MGI:3716256 , PMID:17610846 endocardium formation IEA UniProtKB:P43680 , ensembl:ENSMUSP000000627591600115 GO_REF:0000107 Ensembl GO_REF:0000107 establishment of endothelial barrier ISO RGD:1323321 1624291 (PMID:18065521) RGD PMID:18065521 establishment of endothelial barrier IEA UniProtKB:P35713 , ensembl:ENSP000003418151600115 GO_REF:0000107 Ensembl GO_REF:0000107 hair cycle process ISO RGD:1323321 1624291 (PMID:12740761) RGD PMID:12740761 hair follicle development ISO RGD:1323322 1624291 MGI:MGI:1856135 more ... RGD MGI:MGI:1355042 more ... hair follicle development IEA UniProtKB:P43680 , ensembl:ENSMUSP000000627591600115 GO_REF:0000107 Ensembl GO_REF:0000107 heart development ISO RGD:1323322 1624291 MGI:MGI:1856135 (MGI:MGI:1355042 , PMID:10742113) RGD MGI:MGI:1355042 , PMID:10742113 heart development NOT ISO RGD:1323322 1624291 MGI:MGI:2178809 (MGI:MGI:1927721 , PMID:11094083) RGD MGI:MGI:1927721 , PMID:11094083 in utero embryonic development NOT ISO RGD:1323322 1624291 MGI:MGI:2178809 (MGI:MGI:1927721 , PMID:11094083) RGD MGI:MGI:1927721 , PMID:11094083 in utero embryonic development IEA UniProtKB:P43680 , ensembl:ENSMUSP000000627591600115 GO_REF:0000107 Ensembl GO_REF:0000107 in utero embryonic development ISO RGD:1323322 1624291 MGI:MGI:1856135 more ... RGD MGI:MGI:1355042 more ... lymph vessel development ISO RGD:1323322 1624291 MGI:MGI:1856135 more ... RGD MGI:MGI:3850578 more ... lymphangiogenesis ISO RGD:1323321 1624291 (PMID:12740761) RGD PMID:12740761 lymphangiogenesis IBA MGI:MGI:103559 more ... 13792537 PMID:21873635 GO_Central lymphangiogenesis ISO RGD:1323322 1624291 MGI:MGI:2178809 (MGI:MGI:3828192 , PMID:18931657) RGD MGI:MGI:3828192 , PMID:18931657 lymphatic endothelial cell differentiation ISO RGD:1323322 1624291 MGI:MGI:2178809 (MGI:MGI:3828192 , PMID:18931657) RGD MGI:MGI:3828192 , PMID:18931657 lymphatic endothelial cell differentiation IEA UniProtKB:P43680 , ensembl:ENSMUSP000000627591600115 GO_REF:0000107 Ensembl GO_REF:0000107 mRNA transcription by RNA polymerase II ISO RGD:1323321 1624291 (PMID:22292085) RGD PMID:22292085 mRNA transcription by RNA polymerase II IEA UniProtKB:P35713 , ensembl:ENSP000003418151600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of transcription by RNA polymerase II ISO RGD:1323321 1624291 (PMID:22292085) RGD PMID:22292085 negative regulation of transcription by RNA polymerase II IEA UniProtKB:P35713 , ensembl:ENSP000003418151600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of transcription, DNA-templated ISO RGD:1323322 1624291 (MGI:MGI:3828192, PMID:18931657) RGD MGI:MGI:3828192 , PMID:18931657 positive regulation of transcription by RNA polymerase II ISO RGD:1323321 1624291 (PMID:18065521), (PMID:22292085) RGD PMID:18065521 , PMID:22292085 positive regulation of transcription by RNA polymerase II IBA PANTHER:PTN000814359 , UniProtKB:P35713 13792537 PMID:21873635 GO_Central positive regulation of transcription, DNA-templated ISO RGD:1323322 1624291 (MGI:MGI:1355042 more ... RGD MGI:MGI:1355042 more ... regulation of stem cell proliferation ISO RGD:1323322 1624291 (MGI:MGI:4453910, PMID:20228271) RGD MGI:MGI:4453910 , PMID:20228271 regulation of stem cell proliferation IEA UniProtKB:P43680 , ensembl:ENSMUSP000000627591600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of transcription, DNA-templated ISO RGD:1323322 1624291 (MGI:MGI:2449851, PMID:12446692) RGD MGI:MGI:2449851 , PMID:12446692 regulation of transcription, DNA-templated IBA MGI:MGI:103559 more ... 13792537 PMID:21873635 GO_Central regulation of transcription, DNA-templated IBA FB:FBgn0000411 more ... 13792537 PMID:21873635 GO_Central stem cell fate specification ISO RGD:1323322 1624291 (MGI:MGI:4453910, PMID:20228271) RGD MGI:MGI:4453910 , PMID:20228271 stem cell fate specification IEA UniProtKB:P43680 , ensembl:ENSMUSP000000627591600115 GO_REF:0000107 Ensembl GO_REF:0000107 vasculature development ISO RGD:1323322 1624291 MGI:MGI:1856136 (MGI:MGI:3849921 , PMID:19429912) RGD MGI:MGI:3849921 , PMID:19429912 vasculogenesis ISO RGD:1323322 1624291 MGI:MGI:2178809 more ... RGD MGI:MGI:3664529 , PMID:16895968 vasculogenesis IBA MGI:MGI:103559 , PANTHER:PTN000814359 13792537 PMID:21873635 GO_Central Cellular Component cellular_component ND 1598407 1/2007: no relevant rat data RGD nuclear chromatin ISO RGD:1323321 1624291 (PMID:22292085) RGD PMID:22292085 nuclear chromatin IEA UniProtKB:P35713 , ensembl:ENSP000003418151600115 GO_REF:0000107 Ensembl GO_REF:0000107 nuclear transcription factor complex ISO RGD:1323322 1624291 (MGI:MGI:5494370, PMID:22344693) RGD MGI:MGI:5494370 , PMID:22344693 nuclear transcription factor complex IBA MGI:MGI:103559 more ... 13792537 PMID:21873635 GO_Central nuclear transcription factor complex IBA MGI:MGI:103559 more ... 13792537 PMID:21873635 GO_Central nucleus ISO RGD:1323322 1624291 (MGI:MGI:3828192 more ... RGD MGI:MGI:3828192 more ... nucleus IBA FB:FBgn0000411 more ... 13792537 PMID:21873635 GO_Central nucleus IBA FB:FBgn0000411 more ... 13792537 PMID:21873635 GO_Central nucleus ISO RGD:1323321 1624291 (PMID:18065521) RGD PMID:18065521 Molecular Function DNA binding ISO RGD:1323322 1624291 (MGI:MGI:2449851, PMID:12446692) RGD MGI:MGI:2449851 , PMID:12446692 DNA-binding transcription activator activity, RNA polymerase II-specific ISO RGD:1323321 1624291 (PMID:22292085) RGD PMID:22292085 DNA-binding transcription activator activity, RNA polymerase II-specific IEA UniProtKB:P35713 , ensembl:ENSP000003418151600115 GO_REF:0000107 Ensembl GO_REF:0000107 DNA-binding transcription factor activity ISO RGD:1323322 1624291 (MGI:MGI:1355042 more ... RGD MGI:MGI:1355042 more ... DNA-binding transcription factor activity, RNA polymerase II-specific ISO RGD:1323322 1624291 (MGI:MGI:5494370, PMID:22344693) RGD MGI:MGI:5494370 , PMID:22344693 DNA-binding transcription factor activity, RNA polymerase II-specific IBA MGI:MGI:103559 more ... 13792537 PMID:21873635 GO_Central DNA-binding transcription factor activity, RNA polymerase II-specific IBA FB:FBgn0000411 more ... 13792537 PMID:21873635 GO_Central molecular_function ND 1598407 1/2007: no relevant rat data RGD protein binding ISO RGD:1323322 1624291 UniProtKB:Q8CFN5 (MGI:MGI:5142376 , PMID:11554755) RGD MGI:MGI:5142376 , PMID:11554755 protein binding ISO RGD:1323322 1624291 UniProtKB:P20263 more ... RGD MGI:MGI:5142376 more ... protein heterodimerization activity ISO RGD:1323322 1624291 (MGI:MGI:5494370, PMID:22344693) RGD MGI:MGI:5494370 , PMID:22344693 RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO RGD:1323321 1624291 (PMID:22292085) RGD PMID:22292085 RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA UniProtKB:P35713 , ensembl:ENSP000003418151600115 GO_REF:0000107 Ensembl GO_REF:0000107 sequence-specific DNA binding ISO RGD:1323322 1624291 (MGI:MGI:75639, PMID:7651823) RGD MGI:MGI:75639 , PMID:7651823 transcription regulatory region DNA binding ISO RGD:1323321 1624291 (PMID:18065521) RGD PMID:18065521 transcription regulatory region DNA binding ISO RGD:1323322 1624291 (MGI:MGI:3033511 more ... RGD MGI:MGI:3033511 more ...
Gene-Chemical Interaction Annotations
