Cd46 (CD46 molecule) - Rat Genome Database

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Gene: Cd46 (CD46 molecule) Rattus norvegicus
Analyze
Symbol: Cd46
Name: CD46 molecule
RGD ID: 3061
Description: Contributes to endopeptidase activity. Involved in positive regulation of proteolysis. Located in several cellular components, including Golgi apparatus; basolateral plasma membrane; and inner acrosomal membrane. Biomarker of acute necrotizing pancreatitis. Human ortholog(s) of this gene implicated in several diseases, including atypical hemolytic-uremic syndrome; hemolytic-uremic syndrome; meningococcal meningitis; multiple sclerosis; and pre-eclampsia. Orthologous to human CD46 (CD46 molecule); PARTICIPATES IN coagulation cascade pathway; complement system pathway; measles pathway; INTERACTS WITH 6-propyl-2-thiouracil; acetamide; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CD46 antigen, complement regulatory protein; CD46 molecule, complement regulatory protein; Mcp; membrane cofactor protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.213106,575,586 - 106,606,325 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl13106,574,858 - 106,660,445 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx13109,093,027 - 109,123,671 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.013110,476,854 - 110,507,498 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.013107,701,316 - 107,731,951 (-)NCBIRnor_WKY
Rnor_6.013113,786,525 - 113,818,741 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13113,787,349 - 113,817,995 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013118,334,938 - 118,366,928 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413110,972,812 - 111,003,407 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.113111,166,859 - 111,197,455 (-)NCBI
Celera13105,999,615 - 106,030,131 (-)NCBICelera
Cytogenetic Map13q27NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. CD46 expression and HHV-6 infection in patients with multiple sclerosis. Alvarez-Lafuente R, etal., Acta Neurol Scand. 2009 Oct;120(4):246-50. Epub 2009 May 13.
2. CD46 in a Spanish cohort of multiple sclerosis patients: genetics, mRNA expression and response to interferon-beta treatment. Alvarez-Lafuente R, etal., Mult Scler. 2011 May;17(5):513-20. Epub 2010 Dec 21.
3. Prevalence of anti human herpes virus-6 IgG and its receptor in acute leukemia (membrane cofactor protein: MCP, CD46). Assem MM, etal., J Egypt Natl Canc Inst. 2005 Mar;17(1):29-34.
4. Expression and significance of leukocyte membrane cofactor protein transcript in systemic lupus erythematosus. Biswas B, etal., Lupus. 2012 Apr;21(5):517-25. Epub 2012 Jan 13.
5. Ascitic complement system in ovarian cancer. Bjorge L, etal., Br J Cancer. 2005 Mar 14;92(5):895-905.
6. A possible role of CD46 for the protection in vivo of human renal tumor cells from complement-mediated damage. Blok VT, etal., Lab Invest. 2000 Mar;80(3):335-44.
7. Expression of innate immune complement regulators on brain epithelial cells during human bacterial meningitis. Canova C, etal., J Neuroinflammation. 2006 Sep 2;3:22.
8. Atypical haemolytic uraemic syndrome and mutations in complement regulator genes. Dragon-Durey MA and Fremeaux-Bacchi V, Springer Semin Immunopathol. 2005 Nov;27(3):359-74. Epub 2005 Nov 11.
9. Membrane cofactor protein mutations in atypical hemolytic uremic syndrome (aHUS), fatal Stx-HUS, C3 glomerulonephritis, and the HELLP syndrome. Fang CJ, etal., Blood. 2008 Jan 15;111(2):624-32. Epub 2007 Oct 3.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
12. CD46 protects against chronic obstructive pulmonary disease. Grumelli S, etal., PLoS One. 2011 May 6;6(5):e18785.
13. High expression of the antigen recognized by the monoclonal antibody GB24 on human breast carcinomas: a preventive mechanism of malignant tumor cells against complement attack? Hofman P, etal., Breast Cancer Res Treat. 1994;32(2):213-9.
14. CD46 in meningococcal disease. Johansson L, etal., Science. 2003 Jul 18;301(5631):373-5.
15. Activation of intrarenal complement system in mouse model for chronic cyclosporine nephrotoxicity. Kim YO, etal., Yonsei Med J. 2007 Jun 30;48(3):517-25.
16. Whole blood gene expression profiles distinguish clinical phenotypes of venous thromboembolism. Lewis DA, etal., Thromb Res. 2015 Apr;135(4):659-65. doi: 10.1016/j.thromres.2015.02.003. Epub 2015 Feb 7.
17. Genetic analysis of membrane cofactor protein (CD46) of the complement system in women with and without preeclamptic pregnancies. Lokki AI, etal., PLoS One. 2015 Feb 24;10(2):e0117840. doi: 10.1371/journal.pone.0117840. eCollection 2015.
18. Do poor-prognosis breast tumours express membrane cofactor proteins (CD46)? Madjd Z, etal., Cancer Immunol Immunother. 2005 Feb;54(2):149-56. Epub 2004 Sep 16.
19. Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome. Maga TK, etal., Hum Mutat. 2010 Jun;31(6):E1445-60. doi: 10.1002/humu.21256.
20. Linking innate and acquired immunity: divergent role of CD46 cytoplasmic domains in T cell induced inflammation. Marie JC, etal., Nat Immunol. 2002 Jul;3(7):659-66. Epub 2002 Jun 10.
21. Molecular cloning, expression and characterization of the rat analogue of human membrane cofactor protein (MCP/CD46). Mead R, etal., Immunology. 1999 Sep;98(1):137-43.
22. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
23. Molecular cloning of rat and mouse membrane cofactor protein (MCP, CD46): preferential expression in testis and close linkage between the mouse Mcp and Cr2 genes on distal chromosome 1. Miwa T, etal., Immunogenetics 1998 Nov-Dec;48(6):363-71.
24. Rat membrane cofactor protein (MCP; CD46) is expressed only in the acrosome of developing and mature spermatozoa and mediates binding to immobilized activated C3. Mizuno M, etal., Biol Reprod. 2004 Oct;71(4):1374-83. Epub 2004 Jun 23.
25. Expression of CD46 in developing rat spermatozoa: ultrastructural localization and utility as a marker of the various stages of the seminiferous tubuli. Mizuno M, etal., Biol Reprod. 2005 Apr;72(4):908-15. Epub 2004 Dec 15.
26. Expression of complement regulatory proteins-CD 35, CD 46, CD 55, and CD 59-in benign and malignant endometrial tissue. Murray KP, etal., Gynecol Oncol. 2000 Feb;76(2):176-82.
27. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
28. Relative role of genetic complement abnormalities in sporadic and familial aHUS and their impact on clinical phenotype. Noris M, etal., Clin J Am Soc Nephrol. 2010 Oct;5(10):1844-59. doi: 10.2215/CJN.02210310. Epub 2010 Jul 1.
29. Familial haemolytic uraemic syndrome and an MCP mutation. Noris M, etal., Lancet. 2003 Nov 8;362(9395):1542-7.
30. Use of complement regulators, CD35, CD46, CD55, and CD59, on leukocytes as markers for diagnosis of viral and bacterial infections. Nuutila J, etal., Hum Immunol. 2013 May;74(5):522-30. doi: 10.1016/j.humimm.2013.01.011. Epub 2013 Jan 29.
31. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
32. Oncolytic measles virus targets high CD46 expression on multiple myeloma cells. Ong HT, etal., Exp Hematol. 2006 Jun;34(6):713-20.
33. Intraperitoneal therapy of ovarian cancer using an engineered measles virus. Peng KW, etal., Cancer Res. 2002 Aug 15;62(16):4656-62.
34. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
35. GOA pipeline RGD automated data pipeline
36. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
37. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
38. Mutations in human complement regulator, membrane cofactor protein (CD46), predispose to development of familial hemolytic uremic syndrome. Richards A, etal., Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12966-71. Epub 2003 Oct 17.
39. Mutations in complement regulatory proteins predispose to preeclampsia: a genetic analysis of the PROMISSE cohort. Salmon JE, etal., PLoS Med. 2011 Mar;8(3):e1001013. Epub 2011 Mar 22.
40. Expression of the complement regulatory proteins decay accelerating factor (DAF, CD55), membrane cofactor protein (MCP, CD46) and CD59 in the normal human uterine cervix and in premalignant and malignant cervical disease. Simpson KL, etal., Am J Pathol. 1997 Nov;151(5):1455-67.
41. CD46 expression is indicative of shorter revival-free survival for ovarian cancer patients. Surowiak P, etal., Anticancer Res. 2006 Nov-Dec;26(6C):4943-8.
42. Complement inhibitory proteins expression in placentas of thrombophilic women. Wirstlein PK, etal., Folia Histochem Cytobiol. 2012 Oct 8;50(3):460-7. doi: 10.5603/19758.
43. Expression of decay-accelerating factor (CD55), membrane cofactor protein (CD46) and CD59 in the human astroglioma cell line, D54-MG, and primary rat astrocytes. Yang C, etal., J Neuroimmunol. 1993 Sep;47(2):123-32.
44. A CD46 transgenic mouse model for studying the histopathology of arthritis caused by subcutaneous infection with Streptococcus dysgalactiae subspecies equisimilis. Yoshida H, etal., J Med Microbiol. 2011 Dec;60(Pt 12):1860-8. Epub 2011 Aug 18.
45. Effect of IL-4 on altered expression of complement activation regulators in rat pancreatic cells during severe acute pancreatitis. Zhang C, etal., World J Gastroenterol. 2005 Nov 21;11(43):6770-4.
Additional References at PubMed
PMID:9029106   PMID:12540904   PMID:20458337   PMID:20534589   PMID:21423176   PMID:23086448  


Genomics

Comparative Map Data
Cd46
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.213106,575,586 - 106,606,325 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl13106,574,858 - 106,660,445 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx13109,093,027 - 109,123,671 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.013110,476,854 - 110,507,498 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.013107,701,316 - 107,731,951 (-)NCBIRnor_WKY
Rnor_6.013113,786,525 - 113,818,741 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13113,787,349 - 113,817,995 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013118,334,938 - 118,366,928 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413110,972,812 - 111,003,407 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.113111,166,859 - 111,197,455 (-)NCBI
Celera13105,999,615 - 106,030,131 (-)NCBICelera
Cytogenetic Map13q27NCBI
CD46
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381207,752,038 - 207,795,516 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1207,752,037 - 207,795,513 (+)EnsemblGRCh38hg38GRCh38
GRCh371207,925,383 - 207,968,861 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361205,992,025 - 206,035,481 (+)NCBINCBI36Build 36hg18NCBI36
Build 341204,313,796 - 204,357,253NCBI
Celera1181,155,844 - 181,199,337 (+)NCBICelera
Cytogenetic Map1q32.2NCBI
HuRef1178,599,655 - 178,643,144 (+)NCBIHuRef
CHM1_11209,197,783 - 209,241,259 (+)NCBICHM1_1
T2T-CHM13v2.01206,998,784 - 207,042,279 (+)NCBIT2T-CHM13v2.0
Cd46
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391194,721,279 - 194,781,149 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1194,719,134 - 194,774,557 (-)EnsemblGRCm39 Ensembl
GRCm381195,038,971 - 195,098,784 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1195,036,826 - 195,092,249 (-)EnsemblGRCm38mm10GRCm38
MGSCv371196,868,094 - 196,918,442 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361196,742,624 - 196,792,972 (-)NCBIMGSCv36mm8
Celera1201,941,710 - 201,991,369 (-)NCBICelera
Cytogenetic Map1H6NCBI
cM Map198.41NCBI
Cd46
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540643,002,817 - 43,034,555 (+)NCBIChiLan1.0ChiLan1.0
CD46
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11188,138,616 - 188,182,046 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1188,031,758 - 188,182,046 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01183,330,423 - 183,373,916 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
LOC102156626
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.176,552,121 - 6,581,316 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha76,114,430 - 6,144,443 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.076,240,211 - 6,268,997 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.176,173,438 - 6,203,217 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.076,275,610 - 6,305,657 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.076,316,510 - 6,346,562 (+)NCBIUU_Cfam_GSD_1.0
Cd46
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934467,898,802 - 67,934,998 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365575,136,784 - 5,175,543 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CD46
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.19135,025,439 - 135,078,910 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29148,564,569 - 148,568,279 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CD46
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12521,650,825 - 21,693,898 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2521,655,969 - 21,693,878 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605522,261,845 - 22,304,942 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cd46
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248074,040,639 - 4,074,631 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
Mcp  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.213106,601,612 - 106,602,319 (+)MAPPERmRatBN7.2
Rnor_6.013113,813,298 - 113,814,004NCBIRnor6.0
Rnor_5.013118,361,306 - 118,362,012UniSTSRnor5.0
RGSC_v3.413110,998,710 - 110,999,416UniSTSRGSC3.4
Celera13106,025,434 - 106,026,140UniSTS
Cytogenetic Map13q27UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:88
Count of miRNA genes:77
Interacting mature miRNAs:78
Transcripts:ENSRNOT00000057151
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 6 6 2 9 6
Low 3 43 45 35 13 35 8 9 72 35 32 5 8
Below cutoff 6 6 6 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_019190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006250478 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090621 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090626 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005492232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB010920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC111927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC118802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000057151   ⟹   ENSRNOP00000053980
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl13113,787,349 - 113,817,995 (-)Ensembl
RefSeq Acc Id: NM_019190   ⟹   NP_062063
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.213106,575,663 - 106,606,310 (-)NCBI
Rnor_6.013113,787,349 - 113,817,995 (-)NCBI
Rnor_5.013118,334,938 - 118,366,928 (-)NCBI
RGSC_v3.413110,972,812 - 111,003,407 (-)RGD
Celera13105,999,615 - 106,030,131 (-)RGD
Sequence:
RefSeq Acc Id: XM_006250478   ⟹   XP_006250540
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.213106,575,586 - 106,606,325 (-)NCBI
Rnor_6.013113,786,525 - 113,818,741 (-)NCBI
Rnor_5.013118,334,938 - 118,366,928 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008769849   ⟹   XP_008768071
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.213106,581,358 - 106,606,325 (-)NCBI
Rnor_6.013113,791,793 - 113,818,126 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039090621   ⟹   XP_038946549
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.213106,581,358 - 106,606,325 (-)NCBI
RefSeq Acc Id: XM_039090622   ⟹   XP_038946550
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.213106,575,586 - 106,606,325 (-)NCBI
RefSeq Acc Id: XM_039090623   ⟹   XP_038946551
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.213106,581,358 - 106,606,325 (-)NCBI
RefSeq Acc Id: XM_039090624   ⟹   XP_038946552
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.213106,575,586 - 106,606,325 (-)NCBI
RefSeq Acc Id: XM_039090625   ⟹   XP_038946553
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.213106,581,358 - 106,602,425 (-)NCBI
RefSeq Acc Id: XM_039090626   ⟹   XP_038946554
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.213106,581,358 - 106,602,425 (-)NCBI
RefSeq Acc Id: XM_039090627   ⟹   XP_038946555
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.213106,581,358 - 106,602,274 (-)NCBI
RefSeq Acc Id: XR_005492232
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.213106,575,586 - 106,606,325 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_062063   ⟸   NM_019190
- Peptide Label: precursor
- UniProtKB: Q9Z0M4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006250540   ⟸   XM_006250478
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008768071   ⟸   XM_008769849
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000053980   ⟸   ENSRNOT00000057151
RefSeq Acc Id: XP_038946552   ⟸   XM_039090624
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038946550   ⟸   XM_039090622
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038946551   ⟸   XM_039090623
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038946549   ⟸   XM_039090621
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038946553   ⟸   XM_039090625
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038946554   ⟸   XM_039090626
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038946555   ⟸   XM_039090627
- Peptide Label: isoform X6
Protein Domains
Sushi

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z0M4-F1-model_v2 AlphaFold Q9Z0M4 1-355 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699132
Promoter ID:EPDNEW_R9657
Type:single initiation site
Name:Cd46_1
Description:CD46 molecule
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.013113,818,006 - 113,818,066EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3061 AgrOrtholog
BioCyc Gene G2FUF-16732 BioCyc
Ensembl Genes ENSRNOG00000007917 Ensembl
  ENSRNOG00000008193 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000010798.7 UniProtKB/TrEMBL
  ENSRNOP00000053980 ENTREZGENE
  ENSRNOP00000053980.4 UniProtKB/TrEMBL
  ENSRNOP00000072622.2 UniProtKB/TrEMBL
  ENSRNOP00000074390.2 UniProtKB/TrEMBL
  ENSRNOP00000076787.1 UniProtKB/TrEMBL
  ENSRNOP00000079381 ENTREZGENE
  ENSRNOP00000079381.1 UniProtKB/TrEMBL
  ENSRNOP00000080824 ENTREZGENE
  ENSRNOP00000080824.1 UniProtKB/TrEMBL
  ENSRNOP00000082131.1 UniProtKB/TrEMBL
  ENSRNOP00000091054.1 UniProtKB/TrEMBL
  ENSRNOP00000097736.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000010799.7 UniProtKB/TrEMBL
  ENSRNOT00000057151 ENTREZGENE
  ENSRNOT00000057151.4 UniProtKB/TrEMBL
  ENSRNOT00000079549.2 UniProtKB/TrEMBL
  ENSRNOT00000084320.2 UniProtKB/TrEMBL
  ENSRNOT00000099211.1 UniProtKB/TrEMBL
  ENSRNOT00000100405.1 UniProtKB/TrEMBL
  ENSRNOT00000107463 ENTREZGENE
  ENSRNOT00000107463.1 UniProtKB/TrEMBL
  ENSRNOT00000113067 ENTREZGENE
  ENSRNOT00000113067.1 UniProtKB/TrEMBL
  ENSRNOT00000118720.1 UniProtKB/TrEMBL
  ENSRNOT00000120085.1 UniProtKB/TrEMBL
InterPro CD46 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi/SCR/CCP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi_SCR_CCP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29333 UniProtKB/Swiss-Prot
NCBI Gene 29333 ENTREZGENE
Pfam Sushi UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cd46 PhenoGen
PIRSF TLX_CD46 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SUSHI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CCP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57535 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K7Y0_RAT UniProtKB/TrEMBL
  A0A8I5Y5K8_RAT UniProtKB/TrEMBL
  A0A8I5ZMW2_RAT UniProtKB/TrEMBL
  A0A8I5ZT27_RAT UniProtKB/TrEMBL
  A0A8I5ZTV7_RAT UniProtKB/TrEMBL
  A0A8I6AC67_RAT UniProtKB/TrEMBL
  A0A8I6GMN2_RAT UniProtKB/TrEMBL
  A0A8L2QSL3_RAT UniProtKB/TrEMBL
  A0A8L2R7U2_RAT UniProtKB/TrEMBL
  A0A8L2UIA6_RAT UniProtKB/TrEMBL
  MCP_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-13 Cd46  CD46 molecule  Cd46  CD46 molecule, complement regulatory protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-29 Cd46  CD46 molecule, complement regulatory protein  Cd46  CD46 antigen, complement regulatory protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Cd46  CD46 antigen, complement regulatory protein  Mcp  membrane cofactor protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Mcp  membrane cofactor protein      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression preferentially expressed in testis 69885