Cd46 (CD46 molecule) - Rat Genome Database

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Gene: Cd46 (CD46 molecule) Rattus norvegicus
Analyze
Symbol: Cd46
Name: CD46 molecule
RGD ID: 3061
Description: Contributes to endopeptidase activity. Involved in positive regulation of proteolysis. Located in basolateral plasma membrane; cell surface; and inner acrosomal membrane. Biomarker of acute necrotizing pancreatitis. Human ortholog(s) of this gene implicated in several diseases, including atypical hemolytic-uremic syndrome; hemolytic-uremic syndrome; meningococcal meningitis; multiple sclerosis; and pre-eclampsia. Orthologous to human CD46 (CD46 molecule); PARTICIPATES IN coagulation cascade pathway; complement system pathway; measles pathway; INTERACTS WITH 6-propyl-2-thiouracil; acetamide; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CD46 antigen, complement regulatory protein; CD46 molecule, complement regulatory protein; Mcp; membrane cofactor protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr813109,104,122 - 109,134,903 (-)NCBIGRCr8
mRatBN7.213106,575,586 - 106,606,325 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl13106,574,858 - 106,660,445 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx13109,093,027 - 109,123,671 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.013110,476,854 - 110,507,498 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.013107,701,316 - 107,731,951 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013113,786,525 - 113,818,741 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13113,787,349 - 113,817,995 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013118,334,938 - 118,366,928 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413110,972,812 - 111,003,407 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.113111,166,859 - 111,197,455 (-)NCBI
Celera13105,999,615 - 106,030,131 (-)NCBICelera
Cytogenetic Map13q27NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. CD46 expression and HHV-6 infection in patients with multiple sclerosis. Alvarez-Lafuente R, etal., Acta Neurol Scand. 2009 Oct;120(4):246-50. Epub 2009 May 13.
2. CD46 in a Spanish cohort of multiple sclerosis patients: genetics, mRNA expression and response to interferon-beta treatment. Alvarez-Lafuente R, etal., Mult Scler. 2011 May;17(5):513-20. Epub 2010 Dec 21.
3. Prevalence of anti human herpes virus-6 IgG and its receptor in acute leukemia (membrane cofactor protein: MCP, CD46). Assem MM, etal., J Egypt Natl Canc Inst. 2005 Mar;17(1):29-34.
4. Expression and significance of leukocyte membrane cofactor protein transcript in systemic lupus erythematosus. Biswas B, etal., Lupus. 2012 Apr;21(5):517-25. Epub 2012 Jan 13.
5. Ascitic complement system in ovarian cancer. Bjorge L, etal., Br J Cancer. 2005 Mar 14;92(5):895-905.
6. A possible role of CD46 for the protection in vivo of human renal tumor cells from complement-mediated damage. Blok VT, etal., Lab Invest. 2000 Mar;80(3):335-44.
7. Expression of innate immune complement regulators on brain epithelial cells during human bacterial meningitis. Canova C, etal., J Neuroinflammation. 2006 Sep 2;3:22.
8. Atypical haemolytic uraemic syndrome and mutations in complement regulator genes. Dragon-Durey MA and Fremeaux-Bacchi V, Springer Semin Immunopathol. 2005 Nov;27(3):359-74. Epub 2005 Nov 11.
9. Membrane cofactor protein mutations in atypical hemolytic uremic syndrome (aHUS), fatal Stx-HUS, C3 glomerulonephritis, and the HELLP syndrome. Fang CJ, etal., Blood. 2008 Jan 15;111(2):624-32. Epub 2007 Oct 3.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
12. CD46 protects against chronic obstructive pulmonary disease. Grumelli S, etal., PLoS One. 2011 May 6;6(5):e18785.
13. High expression of the antigen recognized by the monoclonal antibody GB24 on human breast carcinomas: a preventive mechanism of malignant tumor cells against complement attack? Hofman P, etal., Breast Cancer Res Treat. 1994;32(2):213-9.
14. CD46 in meningococcal disease. Johansson L, etal., Science. 2003 Jul 18;301(5631):373-5.
15. Activation of intrarenal complement system in mouse model for chronic cyclosporine nephrotoxicity. Kim YO, etal., Yonsei Med J. 2007 Jun 30;48(3):517-25.
16. Whole blood gene expression profiles distinguish clinical phenotypes of venous thromboembolism. Lewis DA, etal., Thromb Res. 2015 Apr;135(4):659-65. doi: 10.1016/j.thromres.2015.02.003. Epub 2015 Feb 7.
17. Genetic analysis of membrane cofactor protein (CD46) of the complement system in women with and without preeclamptic pregnancies. Lokki AI, etal., PLoS One. 2015 Feb 24;10(2):e0117840. doi: 10.1371/journal.pone.0117840. eCollection 2015.
18. Do poor-prognosis breast tumours express membrane cofactor proteins (CD46)? Madjd Z, etal., Cancer Immunol Immunother. 2005 Feb;54(2):149-56. Epub 2004 Sep 16.
19. Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome. Maga TK, etal., Hum Mutat. 2010 Jun;31(6):E1445-60. doi: 10.1002/humu.21256.
20. Linking innate and acquired immunity: divergent role of CD46 cytoplasmic domains in T cell induced inflammation. Marie JC, etal., Nat Immunol. 2002 Jul;3(7):659-66. Epub 2002 Jun 10.
21. Molecular cloning, expression and characterization of the rat analogue of human membrane cofactor protein (MCP/CD46). Mead R, etal., Immunology. 1999 Sep;98(1):137-43.
22. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
23. Molecular cloning of rat and mouse membrane cofactor protein (MCP, CD46): preferential expression in testis and close linkage between the mouse Mcp and Cr2 genes on distal chromosome 1. Miwa T, etal., Immunogenetics 1998 Nov-Dec;48(6):363-71.
24. Rat membrane cofactor protein (MCP; CD46) is expressed only in the acrosome of developing and mature spermatozoa and mediates binding to immobilized activated C3. Mizuno M, etal., Biol Reprod. 2004 Oct;71(4):1374-83. Epub 2004 Jun 23.
25. Expression of CD46 in developing rat spermatozoa: ultrastructural localization and utility as a marker of the various stages of the seminiferous tubuli. Mizuno M, etal., Biol Reprod. 2005 Apr;72(4):908-15. Epub 2004 Dec 15.
26. Expression of complement regulatory proteins-CD 35, CD 46, CD 55, and CD 59-in benign and malignant endometrial tissue. Murray KP, etal., Gynecol Oncol. 2000 Feb;76(2):176-82.
27. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
28. Relative role of genetic complement abnormalities in sporadic and familial aHUS and their impact on clinical phenotype. Noris M, etal., Clin J Am Soc Nephrol. 2010 Oct;5(10):1844-59. doi: 10.2215/CJN.02210310. Epub 2010 Jul 1.
29. Familial haemolytic uraemic syndrome and an MCP mutation. Noris M, etal., Lancet. 2003 Nov 8;362(9395):1542-7.
30. Use of complement regulators, CD35, CD46, CD55, and CD59, on leukocytes as markers for diagnosis of viral and bacterial infections. Nuutila J, etal., Hum Immunol. 2013 May;74(5):522-30. doi: 10.1016/j.humimm.2013.01.011. Epub 2013 Jan 29.
31. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
32. Oncolytic measles virus targets high CD46 expression on multiple myeloma cells. Ong HT, etal., Exp Hematol. 2006 Jun;34(6):713-20.
33. Intraperitoneal therapy of ovarian cancer using an engineered measles virus. Peng KW, etal., Cancer Res. 2002 Aug 15;62(16):4656-62.
34. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
35. GOA pipeline RGD automated data pipeline
36. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
37. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
38. Mutations in human complement regulator, membrane cofactor protein (CD46), predispose to development of familial hemolytic uremic syndrome. Richards A, etal., Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12966-71. Epub 2003 Oct 17.
39. Mutations in complement regulatory proteins predispose to preeclampsia: a genetic analysis of the PROMISSE cohort. Salmon JE, etal., PLoS Med. 2011 Mar;8(3):e1001013. Epub 2011 Mar 22.
40. Expression of the complement regulatory proteins decay accelerating factor (DAF, CD55), membrane cofactor protein (MCP, CD46) and CD59 in the normal human uterine cervix and in premalignant and malignant cervical disease. Simpson KL, etal., Am J Pathol. 1997 Nov;151(5):1455-67.
41. CD46 expression is indicative of shorter revival-free survival for ovarian cancer patients. Surowiak P, etal., Anticancer Res. 2006 Nov-Dec;26(6C):4943-8.
42. Complement inhibitory proteins expression in placentas of thrombophilic women. Wirstlein PK, etal., Folia Histochem Cytobiol. 2012 Oct 8;50(3):460-7. doi: 10.5603/19758.
43. Expression of decay-accelerating factor (CD55), membrane cofactor protein (CD46) and CD59 in the human astroglioma cell line, D54-MG, and primary rat astrocytes. Yang C, etal., J Neuroimmunol. 1993 Sep;47(2):123-32.
44. A CD46 transgenic mouse model for studying the histopathology of arthritis caused by subcutaneous infection with Streptococcus dysgalactiae subspecies equisimilis. Yoshida H, etal., J Med Microbiol. 2011 Dec;60(Pt 12):1860-8. Epub 2011 Aug 18.
45. Effect of IL-4 on altered expression of complement activation regulators in rat pancreatic cells during severe acute pancreatitis. Zhang C, etal., World J Gastroenterol. 2005 Nov 21;11(43):6770-4.
Additional References at PubMed
PMID:9029106   PMID:12540904   PMID:20458337   PMID:20534589   PMID:21423176   PMID:23086448  


Genomics

Comparative Map Data
Cd46
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr813109,104,122 - 109,134,903 (-)NCBIGRCr8
mRatBN7.213106,575,586 - 106,606,325 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl13106,574,858 - 106,660,445 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx13109,093,027 - 109,123,671 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.013110,476,854 - 110,507,498 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.013107,701,316 - 107,731,951 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013113,786,525 - 113,818,741 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13113,787,349 - 113,817,995 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013118,334,938 - 118,366,928 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413110,972,812 - 111,003,407 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.113111,166,859 - 111,197,455 (-)NCBI
Celera13105,999,615 - 106,030,131 (-)NCBICelera
Cytogenetic Map13q27NCBI
CD46
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381207,752,038 - 207,795,516 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1207,752,037 - 207,795,513 (+)EnsemblGRCh38hg38GRCh38
GRCh371207,925,383 - 207,968,861 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361205,992,025 - 206,035,481 (+)NCBINCBI36Build 36hg18NCBI36
Build 341204,313,796 - 204,357,253NCBI
Celera1181,155,844 - 181,199,337 (+)NCBICelera
Cytogenetic Map1q32.2NCBI
HuRef1178,599,655 - 178,643,144 (+)NCBIHuRef
CHM1_11209,197,783 - 209,241,259 (+)NCBICHM1_1
T2T-CHM13v2.01206,998,784 - 207,042,279 (+)NCBIT2T-CHM13v2.0
Cd46
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391194,721,279 - 194,781,149 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1194,719,134 - 194,774,557 (-)EnsemblGRCm39 Ensembl
GRCm381195,038,971 - 195,098,784 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1195,036,826 - 195,092,249 (-)EnsemblGRCm38mm10GRCm38
MGSCv371196,868,094 - 196,918,442 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361196,742,624 - 196,792,972 (-)NCBIMGSCv36mm8
Celera1201,941,710 - 201,991,369 (-)NCBICelera
Cytogenetic Map1H6NCBI
cM Map198.41NCBI
Cd46
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540643,002,817 - 43,034,555 (+)NCBIChiLan1.0ChiLan1.0
CD46
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2141,603,943 - 41,647,435 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1141,570,052 - 41,613,519 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01183,330,423 - 183,373,916 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11188,138,616 - 188,182,046 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1188,031,758 - 188,182,046 (+)Ensemblpanpan1.1panPan2
LOC102156626
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.176,552,121 - 6,581,316 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha76,114,430 - 6,144,443 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.076,240,211 - 6,268,997 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.176,173,438 - 6,203,217 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.076,275,610 - 6,305,657 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.076,316,510 - 6,346,562 (+)NCBIUU_Cfam_GSD_1.0
Cd46
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934467,898,802 - 67,934,998 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365575,136,784 - 5,175,543 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CD46
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.19135,025,439 - 135,078,910 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29148,564,569 - 148,568,279 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CD46
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12521,650,825 - 21,693,898 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2521,655,969 - 21,693,878 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605522,261,845 - 22,304,942 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cd46
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248074,040,639 - 4,074,631 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cd46
112 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:88
Count of miRNA genes:77
Interacting mature miRNAs:78
Transcripts:ENSRNOT00000057151
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1366451204106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat

Markers in Region
Mcp  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr813109,130,071 - 109,130,778 (+)Marker Load Pipeline
mRatBN7.213106,601,612 - 106,602,319 (+)MAPPERmRatBN7.2
Rnor_6.013113,813,298 - 113,814,004NCBIRnor6.0
Rnor_5.013118,361,306 - 118,362,012UniSTSRnor5.0
RGSC_v3.413110,998,710 - 110,999,416UniSTSRGSC3.4
Celera13106,025,434 - 106,026,140UniSTS
Cytogenetic Map13q27UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000057151   ⟹   ENSRNOP00000053980
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl13113,787,349 - 113,817,995 (-)Ensembl
RefSeq Acc Id: NM_019190   ⟹   NP_062063
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813109,104,123 - 109,134,769 (-)NCBI
mRatBN7.213106,575,663 - 106,606,310 (-)NCBI
Rnor_6.013113,787,349 - 113,817,995 (-)NCBI
Rnor_5.013118,334,938 - 118,366,928 (-)NCBI
RGSC_v3.413110,972,812 - 111,003,407 (-)RGD
Celera13105,999,615 - 106,030,131 (-)RGD
Sequence:
RefSeq Acc Id: XM_006250478   ⟹   XP_006250540
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813109,104,122 - 109,134,903 (-)NCBI
mRatBN7.213106,575,586 - 106,606,325 (-)NCBI
Rnor_6.013113,786,525 - 113,818,741 (-)NCBI
Rnor_5.013118,334,938 - 118,366,928 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008769849   ⟹   XP_008768071
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813109,104,122 - 109,134,903 (-)NCBI
mRatBN7.213106,581,358 - 106,606,325 (-)NCBI
Rnor_6.013113,791,793 - 113,818,126 (-)NCBI
Sequence:
RefSeq Acc Id: NP_062063   ⟸   NM_019190
- Peptide Label: precursor
- UniProtKB: Q9Z0M4 (UniProtKB/Swiss-Prot),   A6JH46 (UniProtKB/TrEMBL),   A0A8I5ZTV7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250540   ⟸   XM_006250478
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZMW2 (UniProtKB/TrEMBL),   A0A8I5ZTV7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008768071   ⟸   XM_008769849
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QSL3 (UniProtKB/TrEMBL),   A0A8I5ZTV7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000053980   ⟸   ENSRNOT00000057151
Protein Domains
Sushi

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z0M4-F1-model_v2 AlphaFold Q9Z0M4 1-355 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699132
Promoter ID:EPDNEW_R9657
Type:single initiation site
Name:Cd46_1
Description:CD46 molecule
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.013113,818,006 - 113,818,066EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3061 AgrOrtholog
BioCyc Gene G2FUF-16732 BioCyc
Ensembl Genes ENSRNOG00000007917 Ensembl
  ENSRNOG00000008193 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000057151.4 UniProtKB/TrEMBL
  ENSRNOT00000107463.1 UniProtKB/TrEMBL
  ENSRNOT00000113067.1 UniProtKB/TrEMBL
  ENSRNOT00000118720.1 UniProtKB/TrEMBL
  ENSRNOT00000120085.1 UniProtKB/TrEMBL
Gene3D-CATH Complement Module, domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CD46 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Compl-Cell_Adhes-Reg UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi/SCR/CCP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi_SCR_CCP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29333 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 29333 ENTREZGENE
PANTHER COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  COMPLEMENT RECEPTOR TYPE 1 UniProtKB/TrEMBL
  MEMBRANE COFACTOR PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Sushi UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cd46 PhenoGen
PIRSF TLX_CD46 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SUSHI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007917 RatGTEx
  ENSRNOG00000008193 RatGTEx
SMART CCP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57535 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5Y5K8_RAT UniProtKB/TrEMBL
  A0A8I5ZMW2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZTV7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GMN2_RAT UniProtKB/TrEMBL
  A0A8L2QSL3 ENTREZGENE, UniProtKB/TrEMBL
  A6JH46 ENTREZGENE, UniProtKB/TrEMBL
  MCP_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-13 Cd46  CD46 molecule  Cd46  CD46 molecule, complement regulatory protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-29 Cd46  CD46 molecule, complement regulatory protein  Cd46  CD46 antigen, complement regulatory protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Cd46  CD46 antigen, complement regulatory protein  Mcp  membrane cofactor protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Mcp  membrane cofactor protein      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression preferentially expressed in testis 69885