Cd46 (CD46 molecule) - Rat Genome Database
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Gene: Cd46 (CD46 molecule) Rattus norvegicus
Analyze
Symbol: Cd46
Name: CD46 molecule
RGD ID: 3061
Description: Contributes to endopeptidase activity. Involved in positive regulation of proteolysis. Localizes to several cellular components, including Golgi apparatus; basolateral plasma membrane; and inner acrosomal membrane. Human ortholog(s) of this gene implicated in several diseases, including atypical hemolytic-uremic syndrome; hemolytic-uremic syndrome; meningococcal meningitis; multiple sclerosis; and pre-eclampsia. Orthologous to human CD46 (CD46 molecule); PARTICIPATES IN coagulation cascade pathway; complement system pathway; measles pathway; INTERACTS WITH 6-propyl-2-thiouracil; acetamide; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: CD46 antigen, complement regulatory protein; CD46 molecule, complement regulatory protein; Mcp; membrane cofactor protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.013113,786,525 - 113,818,741 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13113,787,349 - 113,817,995 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013118,334,938 - 118,366,928 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413110,972,812 - 111,003,407 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.113111,166,859 - 111,197,455 (-)NCBI
Celera13105,999,615 - 106,030,131 (-)NCBICelera
Cytogenetic Map13q27NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Alvarez-Lafuente R, etal., Acta Neurol Scand. 2009 Oct;120(4):246-50. Epub 2009 May 13.
2. Alvarez-Lafuente R, etal., Mult Scler. 2011 May;17(5):513-20. Epub 2010 Dec 21.
3. Assem MM, etal., J Egypt Natl Canc Inst. 2005 Mar;17(1):29-34.
4. Biswas B, etal., Lupus. 2012 Apr;21(5):517-25. Epub 2012 Jan 13.
5. Bjorge L, etal., Br J Cancer. 2005 Mar 14;92(5):895-905.
6. Blok VT, etal., Lab Invest. 2000 Mar;80(3):335-44.
7. Canova C, etal., J Neuroinflammation. 2006 Sep 2;3:22.
8. Dragon-Durey MA and Fremeaux-Bacchi V, Springer Semin Immunopathol. 2005 Nov;27(3):359-74. Epub 2005 Nov 11.
9. Fang CJ, etal., Blood. 2008 Jan 15;111(2):624-32. Epub 2007 Oct 3.
10. GOA data from the GO Consortium
11. Grumelli S, etal., PLoS One. 2011 May 6;6(5):e18785.
12. Hofman P, etal., Breast Cancer Res Treat. 1994;32(2):213-9.
13. Johansson L, etal., Science. 2003 Jul 18;301(5631):373-5.
14. Kim YO, etal., Yonsei Med J. 2007 Jun 30;48(3):517-25.
15. Lewis DA, etal., Thromb Res. 2015 Apr;135(4):659-65. doi: 10.1016/j.thromres.2015.02.003. Epub 2015 Feb 7.
16. Lokki AI, etal., PLoS One. 2015 Feb 24;10(2):e0117840. doi: 10.1371/journal.pone.0117840. eCollection 2015.
17. Madjd Z, etal., Cancer Immunol Immunother. 2005 Feb;54(2):149-56. Epub 2004 Sep 16.
18. Maga TK, etal., Hum Mutat. 2010 Jun;31(6):E1445-60. doi: 10.1002/humu.21256.
19. Marie JC, etal., Nat Immunol. 2002 Jul;3(7):659-66. Epub 2002 Jun 10.
20. Mead R, etal., Immunology. 1999 Sep;98(1):137-43.
21. MGD data from the GO Consortium
22. Miwa T, etal., Immunogenetics 1998 Nov-Dec;48(6):363-71.
23. Mizuno M, etal., Biol Reprod. 2004 Oct;71(4):1374-83. Epub 2004 Jun 23.
24. Mizuno M, etal., Biol Reprod. 2005 Apr;72(4):908-15. Epub 2004 Dec 15.
25. Murray KP, etal., Gynecol Oncol. 2000 Feb;76(2):176-82.
26. NCBI rat LocusLink and RefSeq merged data July 26, 2002
27. Noris M, etal., Clin J Am Soc Nephrol. 2010 Oct;5(10):1844-59. doi: 10.2215/CJN.02210310. Epub 2010 Jul 1.
28. Noris M, etal., Lancet. 2003 Nov 8;362(9395):1542-7.
29. Nuutila J, etal., Hum Immunol. 2013 May;74(5):522-30. doi: 10.1016/j.humimm.2013.01.011. Epub 2013 Jan 29.
30. OMIM Disease Annotation Pipeline
31. Ong HT, etal., Exp Hematol. 2006 Jun;34(6):713-20.
32. Peng KW, etal., Cancer Res. 2002 Aug 15;62(16):4656-62.
33. Pipeline to import KEGG annotations from KEGG into RGD
34. RGD automated data pipeline
35. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
36. RGD automated import pipeline for gene-chemical interactions
37. Richards A, etal., Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12966-71. Epub 2003 Oct 17.
38. Salmon JE, etal., PLoS Med. 2011 Mar;8(3):e1001013. Epub 2011 Mar 22.
39. Simpson KL, etal., Am J Pathol. 1997 Nov;151(5):1455-67.
40. Surowiak P, etal., Anticancer Res. 2006 Nov-Dec;26(6C):4943-8.
41. Wirstlein PK, etal., Folia Histochem Cytobiol. 2012 Oct 8;50(3):460-7. doi: 10.5603/19758.
42. Yang C, etal., J Neuroimmunol. 1993 Sep;47(2):123-32.
43. Yoshida H, etal., J Med Microbiol. 2011 Dec;60(Pt 12):1860-8. Epub 2011 Aug 18.
44. Zhang C, etal., World J Gastroenterol. 2005 Nov 21;11(43):6770-4.
Additional References at PubMed
PMID:9029106   PMID:12540904   PMID:20458337   PMID:20534589   PMID:21423176   PMID:23086448  


Genomics

Comparative Map Data
Cd46
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.013113,786,525 - 113,818,741 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13113,787,349 - 113,817,995 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013118,334,938 - 118,366,928 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413110,972,812 - 111,003,407 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.113111,166,859 - 111,197,455 (-)NCBI
Celera13105,999,615 - 106,030,131 (-)NCBICelera
Cytogenetic Map13q27NCBI
CD46
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1207,752,057 - 207,795,513 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1207,752,054 - 207,795,513 (+)EnsemblGRCh38hg38GRCh38
GRCh381207,752,038 - 207,795,516 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371207,925,383 - 207,968,861 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361205,992,025 - 206,035,481 (+)NCBINCBI36hg18NCBI36
Build 341204,313,796 - 204,357,253NCBI
Celera1181,155,844 - 181,199,337 (+)NCBI
Cytogenetic Map1q32.2NCBI
HuRef1178,599,655 - 178,643,144 (+)NCBIHuRef
CHM1_11209,197,783 - 209,241,259 (+)NCBICHM1_1
Cd46
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391194,721,279 - 194,781,149 (-)NCBIGRCm39mm39
GRCm381195,038,971 - 195,098,784 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1195,036,826 - 195,092,249 (-)EnsemblGRCm38mm10GRCm38
MGSCv371196,868,094 - 196,918,442 (-)NCBIGRCm37mm9NCBIm37
MGSCv361196,742,624 - 196,792,972 (-)NCBImm8
Celera1201,941,710 - 201,991,369 (-)NCBICelera
Cytogenetic Map1H6NCBI
cM Map198.41NCBI
Cd46
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540643,002,817 - 43,034,555 (+)NCBIChiLan1.0ChiLan1.0
CD46
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11188,138,616 - 188,182,046 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1188,031,758 - 188,182,046 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01183,330,423 - 183,373,916 (+)NCBIMhudiblu_PPA_v0panPan3
LOC102156626
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.176,552,121 - 6,581,316 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Cd46
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365575,136,784 - 5,175,543 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CD46
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.19135,025,439 - 135,078,910 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29148,564,569 - 148,568,279 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CD46
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl2521,655,969 - 21,693,878 (-)Ensembl
ChlSab1.12521,650,825 - 21,693,898 (-)NCBI
Cd46
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248074,040,639 - 4,074,631 (-)NCBI

Position Markers
Mcp  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.013113,813,298 - 113,814,004NCBIRnor6.0
Rnor_5.013118,361,306 - 118,362,012UniSTSRnor5.0
RGSC_v3.413110,998,710 - 110,999,416UniSTSRGSC3.4
Celera13106,025,434 - 106,026,140UniSTS
Cytogenetic Map13q27UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1371230858114033958Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1371230858114033958Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1372583716114033958Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)777694986114033958Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1386833393114033958Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:88
Count of miRNA genes:77
Interacting mature miRNAs:78
Transcripts:ENSRNOT00000057151
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 6 6 2 9 6
Low 3 43 45 35 13 35 8 9 72 35 32 5 8
Below cutoff 6 6 6 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000057151   ⟹   ENSRNOP00000053980
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl13113,787,349 - 113,817,995 (-)Ensembl
RefSeq Acc Id: NM_019190   ⟹   NP_062063
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.013113,787,349 - 113,817,995 (-)NCBI
Rnor_5.013118,334,938 - 118,366,928 (-)NCBI
RGSC_v3.413110,972,812 - 111,003,407 (-)RGD
Celera13105,999,615 - 106,030,131 (-)RGD
Sequence:
RefSeq Acc Id: XM_006250478   ⟹   XP_006250540
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.013113,786,525 - 113,818,741 (-)NCBI
Rnor_5.013118,334,938 - 118,366,928 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008769849   ⟹   XP_008768071
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.013113,791,793 - 113,818,126 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_062063   ⟸   NM_019190
- Peptide Label: precursor
- UniProtKB: Q9Z0M4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006250540   ⟸   XM_006250478
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008768071   ⟸   XM_008769849
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000053980   ⟸   ENSRNOT00000057151
Protein Domains
Sushi

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699132
Promoter ID:EPDNEW_R9657
Type:single initiation site
Name:Cd46_1
Description:CD46 molecule
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.013113,818,006 - 113,818,066EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3061 AgrOrtholog
Ensembl Genes ENSRNOG00000007917 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000053980 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000057151 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro CD46 UniProtKB/Swiss-Prot
  Sushi/SCR/CCP_sf UniProtKB/Swiss-Prot
  Sushi_SCR_CCP_dom UniProtKB/Swiss-Prot
KEGG Report rno:29333 UniProtKB/Swiss-Prot
NCBI Gene 29333 ENTREZGENE
Pfam Sushi UniProtKB/Swiss-Prot
PhenoGen Cd46 PhenoGen
PIRSF TLX_CD46 UniProtKB/Swiss-Prot
PROSITE SUSHI UniProtKB/Swiss-Prot
SMART CCP UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57535 UniProtKB/Swiss-Prot
UniGene Rn.163242 ENTREZGENE
UniProt MCP_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-13 Cd46  CD46 molecule  Cd46  CD46 molecule, complement regulatory protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-29 Cd46  CD46 molecule, complement regulatory protein  Cd46  CD46 antigen, complement regulatory protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Cd46  CD46 antigen, complement regulatory protein  Mcp  membrane cofactor protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Mcp  membrane cofactor protein      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression preferentially expressed in testis 69885