Cd46 (CD46 molecule) - Rat Genome Database

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Gene: Cd46 (CD46 molecule) Rattus norvegicus
Analyze
Symbol: Cd46
Name: CD46 molecule
RGD ID: 3061
Description: Contributes to endopeptidase activity. Involved in positive regulation of proteolysis. Located in several cellular components, including Golgi apparatus; basolateral plasma membrane; and inner acrosomal membrane. Biomarker of acute necrotizing pancreatitis. Human ortholog(s) of this gene implicated in several diseases, including atypical hemolytic-uremic syndrome; hemolytic-uremic syndrome; meningococcal meningitis; multiple sclerosis; and pre-eclampsia. Orthologous to human CD46 (CD46 molecule); PARTICIPATES IN coagulation cascade pathway; complement system pathway; measles pathway; INTERACTS WITH 6-propyl-2-thiouracil; acetamide; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CD46 antigen, complement regulatory protein; CD46 molecule, complement regulatory protein; Mcp; membrane cofactor protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.213106,575,586 - 106,606,325 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl13106,574,858 - 106,660,445 (-)Ensembl
Rnor_6.013113,786,525 - 113,818,741 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13113,787,349 - 113,817,995 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013118,334,938 - 118,366,928 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413110,972,812 - 111,003,407 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.113111,166,859 - 111,197,455 (-)NCBI
Celera13105,999,615 - 106,030,131 (-)NCBICelera
Cytogenetic Map13q27NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Alvarez-Lafuente R, etal., Acta Neurol Scand. 2009 Oct;120(4):246-50. Epub 2009 May 13.
2. Alvarez-Lafuente R, etal., Mult Scler. 2011 May;17(5):513-20. Epub 2010 Dec 21.
3. Assem MM, etal., J Egypt Natl Canc Inst. 2005 Mar;17(1):29-34.
4. Biswas B, etal., Lupus. 2012 Apr;21(5):517-25. Epub 2012 Jan 13.
5. Bjorge L, etal., Br J Cancer. 2005 Mar 14;92(5):895-905.
6. Blok VT, etal., Lab Invest. 2000 Mar;80(3):335-44.
7. Canova C, etal., J Neuroinflammation. 2006 Sep 2;3:22.
8. Dragon-Durey MA and Fremeaux-Bacchi V, Springer Semin Immunopathol. 2005 Nov;27(3):359-74. Epub 2005 Nov 11.
9. Fang CJ, etal., Blood. 2008 Jan 15;111(2):624-32. Epub 2007 Oct 3.
10. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. GOA data from the GO Consortium
12. Grumelli S, etal., PLoS One. 2011 May 6;6(5):e18785.
13. Hofman P, etal., Breast Cancer Res Treat. 1994;32(2):213-9.
14. Johansson L, etal., Science. 2003 Jul 18;301(5631):373-5.
15. Kim YO, etal., Yonsei Med J. 2007 Jun 30;48(3):517-25.
16. Lewis DA, etal., Thromb Res. 2015 Apr;135(4):659-65. doi: 10.1016/j.thromres.2015.02.003. Epub 2015 Feb 7.
17. Lokki AI, etal., PLoS One. 2015 Feb 24;10(2):e0117840. doi: 10.1371/journal.pone.0117840. eCollection 2015.
18. Madjd Z, etal., Cancer Immunol Immunother. 2005 Feb;54(2):149-56. Epub 2004 Sep 16.
19. Maga TK, etal., Hum Mutat. 2010 Jun;31(6):E1445-60. doi: 10.1002/humu.21256.
20. Marie JC, etal., Nat Immunol. 2002 Jul;3(7):659-66. Epub 2002 Jun 10.
21. Mead R, etal., Immunology. 1999 Sep;98(1):137-43.
22. MGD data from the GO Consortium
23. Miwa T, etal., Immunogenetics 1998 Nov-Dec;48(6):363-71.
24. Mizuno M, etal., Biol Reprod. 2004 Oct;71(4):1374-83. Epub 2004 Jun 23.
25. Mizuno M, etal., Biol Reprod. 2005 Apr;72(4):908-15. Epub 2004 Dec 15.
26. Murray KP, etal., Gynecol Oncol. 2000 Feb;76(2):176-82.
27. NCBI rat LocusLink and RefSeq merged data July 26, 2002
28. Noris M, etal., Clin J Am Soc Nephrol. 2010 Oct;5(10):1844-59. doi: 10.2215/CJN.02210310. Epub 2010 Jul 1.
29. Noris M, etal., Lancet. 2003 Nov 8;362(9395):1542-7.
30. Nuutila J, etal., Hum Immunol. 2013 May;74(5):522-30. doi: 10.1016/j.humimm.2013.01.011. Epub 2013 Jan 29.
31. OMIM Disease Annotation Pipeline
32. Ong HT, etal., Exp Hematol. 2006 Jun;34(6):713-20.
33. Peng KW, etal., Cancer Res. 2002 Aug 15;62(16):4656-62.
34. Pipeline to import KEGG annotations from KEGG into RGD
35. RGD automated data pipeline
36. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
37. RGD automated import pipeline for gene-chemical interactions
38. Richards A, etal., Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12966-71. Epub 2003 Oct 17.
39. Salmon JE, etal., PLoS Med. 2011 Mar;8(3):e1001013. Epub 2011 Mar 22.
40. Simpson KL, etal., Am J Pathol. 1997 Nov;151(5):1455-67.
41. Surowiak P, etal., Anticancer Res. 2006 Nov-Dec;26(6C):4943-8.
42. Wirstlein PK, etal., Folia Histochem Cytobiol. 2012 Oct 8;50(3):460-7. doi: 10.5603/19758.
43. Yang C, etal., J Neuroimmunol. 1993 Sep;47(2):123-32.
44. Yoshida H, etal., J Med Microbiol. 2011 Dec;60(Pt 12):1860-8. Epub 2011 Aug 18.
45. Zhang C, etal., World J Gastroenterol. 2005 Nov 21;11(43):6770-4.
Additional References at PubMed
PMID:9029106   PMID:12540904   PMID:20458337   PMID:20534589   PMID:21423176   PMID:23086448  


Genomics

Comparative Map Data
Cd46
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.213106,575,586 - 106,606,325 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl13106,574,858 - 106,660,445 (-)Ensembl
Rnor_6.013113,786,525 - 113,818,741 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13113,787,349 - 113,817,995 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013118,334,938 - 118,366,928 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413110,972,812 - 111,003,407 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.113111,166,859 - 111,197,455 (-)NCBI
Celera13105,999,615 - 106,030,131 (-)NCBICelera
Cytogenetic Map13q27NCBI
CD46
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381207,752,038 - 207,795,516 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1207,752,037 - 207,795,513 (+)EnsemblGRCh38hg38GRCh38
GRCh371207,925,383 - 207,968,861 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361205,992,025 - 206,035,481 (+)NCBINCBI36hg18NCBI36
Build 341204,313,796 - 204,357,253NCBI
Celera1181,155,844 - 181,199,337 (+)NCBI
Cytogenetic Map1q32.2NCBI
HuRef1178,599,655 - 178,643,144 (+)NCBIHuRef
CHM1_11209,197,783 - 209,241,259 (+)NCBICHM1_1
T2T-CHM13v2.01206,998,784 - 207,042,279 (+)NCBI
Cd46
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391194,721,279 - 194,781,149 (-)NCBIGRCm39mm39
GRCm39 Ensembl1194,719,134 - 194,774,557 (-)Ensembl
GRCm381195,038,971 - 195,098,784 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1195,036,826 - 195,092,249 (-)EnsemblGRCm38mm10GRCm38
MGSCv371196,868,094 - 196,918,442 (-)NCBIGRCm37mm9NCBIm37
MGSCv361196,742,624 - 196,792,972 (-)NCBImm8
Celera1201,941,710 - 201,991,369 (-)NCBICelera
Cytogenetic Map1H6NCBI
cM Map198.41NCBI
Cd46
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540643,002,817 - 43,034,555 (+)NCBIChiLan1.0ChiLan1.0
CD46
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11188,138,616 - 188,182,046 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1188,031,758 - 188,182,046 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01183,330,423 - 183,373,916 (+)NCBIMhudiblu_PPA_v0panPan3
LOC102156626
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.176,552,121 - 6,581,316 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha76,114,430 - 6,144,443 (+)NCBI
ROS_Cfam_1.076,240,211 - 6,268,997 (+)NCBI
UMICH_Zoey_3.176,173,438 - 6,203,217 (+)NCBI
UNSW_CanFamBas_1.076,275,610 - 6,305,657 (+)NCBI
UU_Cfam_GSD_1.076,316,510 - 6,346,562 (+)NCBI
Cd46
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934467,898,802 - 67,934,998 (-)NCBI
SpeTri2.0NW_0049365575,136,784 - 5,175,543 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CD46
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.19135,025,439 - 135,078,910 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29148,564,569 - 148,568,279 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CD46
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12521,650,825 - 21,693,898 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2521,655,969 - 21,693,878 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605522,261,845 - 22,304,942 (-)NCBIVero_WHO_p1.0
Cd46
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248074,040,639 - 4,074,631 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
Mcp  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.213106,601,612 - 106,602,319 (+)MAPPERmRatBN7.2
Rnor_6.013113,813,298 - 113,814,004NCBIRnor6.0
Rnor_5.013118,361,306 - 118,362,012UniSTSRnor5.0
RGSC_v3.413110,998,710 - 110,999,416UniSTSRGSC3.4
Celera13106,025,434 - 106,026,140UniSTS
Cytogenetic Map13q27UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:88
Count of miRNA genes:77
Interacting mature miRNAs:78
Transcripts:ENSRNOT00000057151
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 6 6 2 9 6
Low 3 43 45 35 13 35 8 9 72 35 32 5 8
Below cutoff 6 6 6 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_019190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006250478 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090621 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090626 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005492232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB010920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC111927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC118802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000057151   ⟹   ENSRNOP00000053980
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl13113,787,349 - 113,817,995 (-)Ensembl
RefSeq Acc Id: NM_019190   ⟹   NP_062063
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.213106,575,663 - 106,606,310 (-)NCBI
Rnor_6.013113,787,349 - 113,817,995 (-)NCBI
Rnor_5.013118,334,938 - 118,366,928 (-)NCBI
RGSC_v3.413110,972,812 - 111,003,407 (-)RGD
Celera13105,999,615 - 106,030,131 (-)RGD
Sequence:
RefSeq Acc Id: XM_006250478   ⟹   XP_006250540
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.213106,575,586 - 106,606,325 (-)NCBI
Rnor_6.013113,786,525 - 113,818,741 (-)NCBI
Rnor_5.013118,334,938 - 118,366,928 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008769849   ⟹   XP_008768071
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.213106,581,358 - 106,606,325 (-)NCBI
Rnor_6.013113,791,793 - 113,818,126 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039090621   ⟹   XP_038946549
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.213106,581,358 - 106,606,325 (-)NCBI
RefSeq Acc Id: XM_039090622   ⟹   XP_038946550
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.213106,575,586 - 106,606,325 (-)NCBI
RefSeq Acc Id: XM_039090623   ⟹   XP_038946551
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.213106,581,358 - 106,606,325 (-)NCBI
RefSeq Acc Id: XM_039090624   ⟹   XP_038946552
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.213106,575,586 - 106,606,325 (-)NCBI
RefSeq Acc Id: XM_039090625   ⟹   XP_038946553
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.213106,581,358 - 106,602,425 (-)NCBI
RefSeq Acc Id: XM_039090626   ⟹   XP_038946554
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.213106,581,358 - 106,602,425 (-)NCBI
RefSeq Acc Id: XM_039090627   ⟹   XP_038946555
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.213106,581,358 - 106,602,274 (-)NCBI
RefSeq Acc Id: XR_005492232
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.213106,575,586 - 106,606,325 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_062063   ⟸   NM_019190
- Peptide Label: precursor
- UniProtKB: Q9Z0M4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006250540   ⟸   XM_006250478
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008768071   ⟸   XM_008769849
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000053980   ⟸   ENSRNOT00000057151
RefSeq Acc Id: XP_038946552   ⟸   XM_039090624
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038946550   ⟸   XM_039090622
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038946551   ⟸   XM_039090623
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038946549   ⟸   XM_039090621
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038946553   ⟸   XM_039090625
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038946554   ⟸   XM_039090626
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038946555   ⟸   XM_039090627
- Peptide Label: isoform X6
Protein Domains
Sushi

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z0M4-F1-model_v2 AlphaFold Q9Z0M4 1-355 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699132
Promoter ID:EPDNEW_R9657
Type:single initiation site
Name:Cd46_1
Description:CD46 molecule
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.013113,818,006 - 113,818,066EPDNEW

Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3061 AgrOrtholog
BioCyc Gene G2FUF-16732 BioCyc
Ensembl Genes ENSRNOG00000007917 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00000008193 Ensembl, ENTREZGENE
Ensembl Protein ENSRNOP00000053980 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000079381 ENTREZGENE
  ENSRNOP00000080824 ENTREZGENE
Ensembl Transcript ENSRNOT00000057151 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000107463 ENTREZGENE
  ENSRNOT00000113067 ENTREZGENE
InterPro CD46 UniProtKB/Swiss-Prot
  Sushi/SCR/CCP_sf UniProtKB/Swiss-Prot
  Sushi_SCR_CCP_dom UniProtKB/Swiss-Prot
KEGG Report rno:29333 UniProtKB/Swiss-Prot
NCBI Gene 29333 ENTREZGENE
Pfam Sushi UniProtKB/Swiss-Prot
PhenoGen Cd46 PhenoGen
PIRSF TLX_CD46 UniProtKB/Swiss-Prot
PROSITE SUSHI UniProtKB/Swiss-Prot
SMART CCP UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57535 UniProtKB/Swiss-Prot
UniProt MCP_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-13 Cd46  CD46 molecule  Cd46  CD46 molecule, complement regulatory protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-29 Cd46  CD46 molecule, complement regulatory protein  Cd46  CD46 antigen, complement regulatory protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Cd46  CD46 antigen, complement regulatory protein  Mcp  membrane cofactor protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Mcp  membrane cofactor protein      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression preferentially expressed in testis 69885