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Gene: Cd46 (CD46 molecule) Rattus norvegicus
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Symbol: Cd46
Name: CD46 molecule
Description: Exhibits complement binding activity. Contributes to endopeptidase activity and enzyme inhibitor activity. Involved in negative regulation of complement activation and proteolysis. Localizes to several cellular components, including the Golgi apparatus; basolateral plasma membrane; and inner acrosomal membrane. Human ortholog(s) of this gene implicated in several diseases, including atypical hemolytic-uremic syndrome; contact dermatitis; hemolytic-uremic syndrome; meningococcal meningitis; and multiple sclerosis. Orthologous to human CD46 (CD46 molecule); PARTICIPATES IN coagulation cascade pathway; complement system pathway; measles pathway; INTERACTS WITH 6-propyl-2-thiouracil; acrylamide; aflatoxin B1.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: CD46 antigen, complement regulatory protein; CD46 molecule, complement regulatory protein; Mcp; membrane cofactor protein
Orthologs:
Homo sapiens (human) : CD46 (CD46 molecule)  HGNC  Alliance
Mus musculus (house mouse) : Cd46 (CD46 antigen, complement regulatory protein)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cd46 (CD46 molecule)
Pan paniscus (bonobo/pygmy chimpanzee) : CD46 (CD46 molecule)
Canis lupus familiaris (dog) : LOC102156626 (membrane cofactor protein-like)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cd46 (CD46 molecule)
Sus scrofa (pig) : CD46 (CD46 molecule, complement regulatory protein)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.013113,786,525 - 113,818,741 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13113,787,349 - 113,817,995 (-)Ensembl
Rnor_5.013118,334,938 - 118,366,928 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413110,972,812 - 111,003,407 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.113111,166,859 - 111,197,455 (-)NCBI
Celera13105,999,615 - 106,030,131 (-)NCBICelera
Cytogenetic Map13q27NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Cd46
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3061
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.