RGD Reference Report - Use of complement regulators, CD35, CD46, CD55, and CD59, on leukocytes as markers for diagnosis of viral and bacterial infections. - Rat Genome Database

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Use of complement regulators, CD35, CD46, CD55, and CD59, on leukocytes as markers for diagnosis of viral and bacterial infections.

Authors: Nuutila, J  Jalava-Karvinen, P  Hohenthal, U  Kotilainen, P  Pelliniemi, TT  Nikoskelainen, J  Lilius, EM 
Citation: Nuutila J, etal., Hum Immunol. 2013 May;74(5):522-30. doi: 10.1016/j.humimm.2013.01.011. Epub 2013 Jan 29.
RGD ID: 11352813
Pubmed: PMID:23376460   (View Abstract at PubMed)
DOI: DOI:10.1016/j.humimm.2013.01.011   (Journal Full-text)

Several complement regulatory proteins exist on self-cells to prevent damage by the serum complement system. In the present study, we aimed to perform quantitative analysis of membrane-bound complement regulators, CR1 (CD35), MCP (CD46), DAF (CD55), and MIRL (CD59), on peripheral blood neutrophils, monocytes, and lymphocytes from healthy controls (n=36) and febrile patients diagnosed with either bacterial (n=21) or viral (n=26) infections. Our results show that: (a) increased CD35 and CD55 levels on neutrophils and monocytes present potent markers of bacterial infection, (b) increased expression of CD46 on monocytes is an indicator of viral infection, and (c) increased CD59 expression on neutrophils and monocytes is a general infection marker. Additionally, CD19-positive B-lymphocytes represent practically the only lymphocyte population capable of expressing CD35. We further developed two novel clinical flow cytometric markers (indices), specifically, clinical mononucleosis (CM)-INDEX (incorporating CD35, CD55, and CD59 expression on lymphocytes) and clinical bacterial infection (CBI)-INDEX (incorporating CD35 and CD55 expression on neutrophils and lymphocytes), for the effective detection of viral mononucleosis and bacterial infection, respectively. In summary, bacterial and viral infections induce different expression patterns of membrane-bound complement regulators in human leukocytes, which may be effectively exploited in clinical differential diagnosis.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CD46Humanviral infectious disease  IEP protein:increased expression:monocyte (human)RGD 
Cd46Ratviral infectious disease  ISOCD46 (Homo sapiens)protein:increased expression:monocyte (human)RGD 
Cd46Mouseviral infectious disease  ISOCD46 (Homo sapiens)protein:increased expression:monocyte (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cd46  (CD46 molecule)

Genes (Mus musculus)
Cd46  (CD46 antigen, complement regulatory protein)

Genes (Homo sapiens)
CD46  (CD46 molecule)


Additional Information