RGD Reference Report - Expression of the complement regulatory proteins decay accelerating factor (DAF, CD55), membrane cofactor protein (MCP, CD46) and CD59 in the normal human uterine cervix and in premalignant and malignant cervical disease. - Rat Genome Database

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Expression of the complement regulatory proteins decay accelerating factor (DAF, CD55), membrane cofactor protein (MCP, CD46) and CD59 in the normal human uterine cervix and in premalignant and malignant cervical disease.

Authors: Simpson, KL  Jones, A  Norman, S  Holmes, CH 
Citation: Simpson KL, etal., Am J Pathol. 1997 Nov;151(5):1455-67.
RGD ID: 2293549
Pubmed: PMID:9358772   (View Abstract at PubMed)
PMCID: PMC1858073   (View Article at PubMed Central)

The membrane-bound complement regulators decay-accelerating factor (DAF, CD55), membrane cofactor protein (MCP, CD46), and CD59 are broadly expressed proteins that act together to protect host tissues from autologous complement. Comparison of expression profiles of these proteins between normal and pathological tissues could reveal a mechanism by which tumor cells evade complement-mediated killing. Expression of the regulators was therefore examined in the normal human uterine cervix, in cervical intraepithelial neoplasia (CIN; n = 23), and in cervical squamous carcinomas (n = 6). DAF and MCP were reciprocally expressed in normal ectocervical epithelium. MCP was confined predominantly to the basal and parabasal layers with more extensive expression in metaplastic squamous epithelium. An apparent expansion in MCP expression was observed in more severe premalignant lesions whereas cervical carcinoma were uniformly MCP positive. By contrast, DAF expression appeared unaltered in premalignant lesions and variable in carcinomas. However, increased DAF was observed in stromal cells directly adjacent to infiltrating tumor cells. A low molecular weight DAF product was detected in tumors, and preliminary evidence suggests this may be derived from stromal cells. Overall, changes in expression of C3 convertase regulators in both the stromal and epithelial compartments may be important for evasion of immune surveillance in cervical cancer.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cervical cancer  IEP 2293549 RGD 
cervical cancer  ISOCD55 (Homo sapiens)2293549; 2293549 RGD 
cervix uteri carcinoma in situ  IEP 2293549protein:increased expression:uterine cervixRGD 
cervix uteri carcinoma in situ  ISOCD46 (Homo sapiens)2293549; 2293549protein:increased expression:uterine cervixRGD 
Uterine Cervical Neoplasms  IEP 2293549protein:increased expression and altered expression pattern:tumor:intense uniform staining of tumor cells vs heterogeneous staining of normal tissue and premalignant lesionsRGD 
Uterine Cervical Neoplasms  ISOCD46 (Homo sapiens)2293549; 2293549 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cd46  (CD46 molecule)
Cd55  (CD55 molecule (Cromer blood group))

Genes (Mus musculus)
Cd46  (CD46 antigen, complement regulatory protein)
Cd55  (CD55 molecule, decay accelerating factor for complement)

Genes (Homo sapiens)
CD46  (CD46 molecule)
CD55  (CD55 molecule (Cromer blood group))


Additional Information