RGD Reference Report - Expression of complement regulatory proteins-CD 35, CD 46, CD 55, and CD 59-in benign and malignant endometrial tissue. - Rat Genome Database

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Expression of complement regulatory proteins-CD 35, CD 46, CD 55, and CD 59-in benign and malignant endometrial tissue.

Authors: Murray, KP  Mathure, S  Kaul, R  Khan, S  Carson, LF  Twiggs, LB  Martens, MG  Kaul, A 
Citation: Murray KP, etal., Gynecol Oncol. 2000 Feb;76(2):176-82.
RGD ID: 2293548
Pubmed: PMID:10637067   (View Abstract at PubMed)
DOI: DOI:10.1006/gyno.1999.5614   (Journal Full-text)

OBJECTIVE: Complement system plays an important role in host defense mechanisms against microorganisms and tumor cells. To protect themselves from autologous complement-mediated damage, normal host tissues express cell membrane-associated complement regulatory proteins (CRPs). To investigate whether neoplastic endometrial tissues overexpress these proteins to escape complement damage, we examined the distribution of complement receptor type 1 (CR1, CD35), membrane cofactor protein (MCP, CD46), decay-accelerating factor (DAF, CD55), and protectin (MACIF, CD59) on frozen endometrial tissue samples. METHODS: A total of 54 endometrial tissue samples were collected. Cryosections were obtained of 31 benign and 23 malignant tissue specimens. Tissue sections were stained by immunohistochemical staining procedure using specific antibodies and employing the avidin-biotin technique. Quantitation of the protein content of these CRPs was determined using the Samba 4000 image analysis system. RESULTS: For all four of the CRPs studied, a statistically significant difference in protein expression between the benign and malignant endometrial tissue specimens (P < 0.0001) was observed. CONCLUSIONS: Overexpression of all the CRPs studied (CD35, CD46, CD55, CD59) was observed in the malignant as compared with the benign endometrial tissues. The upregulation of these CRPs may promote resistance of the endometrial malignant tissue to complement-mediated damage, thereby allowing the tumor cells to escape from cytolysis and thus promoting carcinogenesis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
endometrial cancer  IEP 2293548protein:increased expression:endometriumRGD 
endometrial cancer  ISOCD59 (Homo sapiens)2293548; 2293548protein:increased expression:endometriumRGD 
Endometrial Neoplasms  IEP 2293548protein:increased expression:tumor:versus benign endometrium (p<0.0001)RGD 
Endometrial Neoplasms  ISOCD46 (Homo sapiens)2293548; 2293548 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cd46  (CD46 molecule)
Cd59b  (CD59b molecule)

Genes (Mus musculus)
Cd46  (CD46 antigen, complement regulatory protein)
Cd59b  (CD59b antigen)

Genes (Homo sapiens)
CD46  (CD46 molecule)
CD59  (CD59 molecule (CD59 blood group))


Additional Information