CD46 (CD46 molecule) - Rat Genome Database

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Gene: CD46 (CD46 molecule) Chlorocebus sabaeus
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Symbol: CD46
Name: CD46 molecule
RGD ID: 18558349
Description: ENCODES a protein that exhibits endopeptidase activity (ortholog); INVOLVED IN negative regulation of complement activation, alternative pathway (ortholog); negative regulation of complement activation, classical pathway (ortholog); positive regulation of proteolysis (ortholog); ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); acute necrotizing pancreatitis (ortholog); age related macular degeneration (ortholog); FOUND IN acrosomal vesicle (ortholog); basolateral plasma membrane (ortholog); cell surface (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: membrane cofactor protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12521,650,825 - 21,693,898 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2521,655,969 - 21,693,878 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605522,261,845 - 22,304,942 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CD46
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12521,650,825 - 21,693,898 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2521,655,969 - 21,693,878 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605522,261,845 - 22,304,942 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
CD46
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381207,752,038 - 207,795,516 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1207,752,037 - 207,795,513 (+)EnsemblGRCh38hg38GRCh38
GRCh371207,925,383 - 207,968,861 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361205,992,025 - 206,035,481 (+)NCBINCBI36Build 36hg18NCBI36
Build 341204,313,796 - 204,357,253NCBI
Celera1181,155,844 - 181,199,337 (+)NCBICelera
Cytogenetic Map1q32.2NCBI
HuRef1178,599,655 - 178,643,144 (+)NCBIHuRef
CHM1_11209,197,783 - 209,241,259 (+)NCBICHM1_1
T2T-CHM13v2.01206,998,784 - 207,042,279 (+)NCBIT2T-CHM13v2.0
Cd46
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391194,721,279 - 194,781,149 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1194,719,134 - 194,774,557 (-)EnsemblGRCm39 Ensembl
GRCm381195,038,971 - 195,098,784 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1195,036,826 - 195,092,249 (-)EnsemblGRCm38mm10GRCm38
MGSCv371196,868,094 - 196,918,442 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361196,742,624 - 196,792,972 (-)NCBIMGSCv36mm8
Celera1201,941,710 - 201,991,369 (-)NCBICelera
Cytogenetic Map1H6NCBI
cM Map198.41NCBI
Cd46
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr813109,104,122 - 109,134,903 (-)NCBIGRCr8
mRatBN7.213106,575,586 - 106,606,325 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl13106,574,858 - 106,660,445 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx13109,093,027 - 109,123,671 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.013110,476,854 - 110,507,498 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.013107,701,316 - 107,731,951 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013113,786,525 - 113,818,741 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13113,787,349 - 113,817,995 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013118,334,938 - 118,366,928 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413110,972,812 - 111,003,407 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.113111,166,859 - 111,197,455 (-)NCBI
Celera13105,999,615 - 106,030,131 (-)NCBICelera
Cytogenetic Map13q27NCBI
Cd46
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540643,002,817 - 43,034,555 (+)NCBIChiLan1.0ChiLan1.0
CD46
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2141,603,943 - 41,647,435 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1141,570,052 - 41,613,519 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01183,330,423 - 183,373,916 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11188,138,616 - 188,182,046 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1188,031,758 - 188,182,046 (+)Ensemblpanpan1.1panPan2
LOC609365
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.176,602,762 - 6,646,561 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha76,165,486 - 6,209,312 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.076,291,331 - 6,335,169 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.176,224,190 - 6,268,010 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.076,326,697 - 6,370,512 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.076,367,603 - 6,411,471 (+)NCBIUU_Cfam_GSD_1.0
Cd46
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934467,898,802 - 67,934,998 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365575,136,784 - 5,175,543 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CD46
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.19135,025,439 - 135,078,910 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29148,564,569 - 148,568,279 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Cd46
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248074,040,639 - 4,074,631 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000013282   ⟹   ENSCSAP00000011287
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2521,655,969 - 21,693,878 (-)Ensembl
RefSeq Acc Id: XM_007988611   ⟹   XP_007986802
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12521,650,825 - 21,693,898 (-)NCBI
Vero_WHO_p1.0NW_02366605522,261,845 - 22,304,942 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007988612   ⟹   XP_007986803
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12521,650,825 - 21,693,898 (-)NCBI
Vero_WHO_p1.0NW_02366605522,261,845 - 22,304,942 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007988613   ⟹   XP_007986804
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12521,650,825 - 21,693,898 (-)NCBI
Vero_WHO_p1.0NW_02366605522,261,845 - 22,304,942 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007988614   ⟹   XP_007986805
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12521,650,825 - 21,693,838 (-)NCBI
Vero_WHO_p1.0NW_02366605522,261,845 - 22,304,882 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007988616   ⟹   XP_007986807
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12521,650,825 - 21,693,898 (-)NCBI
Vero_WHO_p1.0NW_02366605522,261,845 - 22,304,942 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007988617   ⟹   XP_007986808
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12521,650,825 - 21,693,898 (-)NCBI
Vero_WHO_p1.0NW_02366605522,261,845 - 22,304,942 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007988618   ⟹   XP_007986809
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12521,650,825 - 21,693,865 (-)NCBI
Vero_WHO_p1.0NW_02366605522,261,845 - 22,304,925 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007988620   ⟹   XP_007986811
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12521,650,825 - 21,693,838 (-)NCBI
Vero_WHO_p1.0NW_02366605522,261,845 - 22,304,942 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007988621   ⟹   XP_007986812
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12521,650,825 - 21,693,898 (-)NCBI
Vero_WHO_p1.0NW_02366605522,261,845 - 22,304,942 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037985610   ⟹   XP_037841538
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605522,261,845 - 22,304,942 (-)NCBI
RefSeq Acc Id: XM_037985611   ⟹   XP_037841539
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605522,261,845 - 22,304,942 (-)NCBI
RefSeq Acc Id: XP_007986808   ⟸   XM_007988617
- Peptide Label: isoform X6
RefSeq Acc Id: XP_007986812   ⟸   XM_007988621
- Peptide Label: isoform X11
RefSeq Acc Id: XP_007986804   ⟸   XM_007988613
- Peptide Label: isoform X3
RefSeq Acc Id: XP_007986807   ⟸   XM_007988616
- Peptide Label: isoform X5
RefSeq Acc Id: XP_007986802   ⟸   XM_007988611
- Peptide Label: isoform X1
RefSeq Acc Id: XP_007986803   ⟸   XM_007988612
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RRP8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007986809   ⟸   XM_007988618
- Peptide Label: isoform X8
RefSeq Acc Id: XP_007986805   ⟸   XM_007988614
- Peptide Label: isoform X4
RefSeq Acc Id: XP_007986811   ⟸   XM_007988620
- Peptide Label: isoform X9
Ensembl Acc Id: ENSCSAP00000011287   ⟸   ENSCSAT00000013282
RefSeq Acc Id: XP_037841538   ⟸   XM_037985610
- Peptide Label: isoform X7
RefSeq Acc Id: XP_037841539   ⟸   XM_037985611
- Peptide Label: isoform X10


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000015190 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000013282.1 UniProtKB/TrEMBL
Gene3D-CATH Complement Module, domain 1 UniProtKB/TrEMBL
InterPro CD46 UniProtKB/TrEMBL
  Compl-Cell_Adhes-Reg UniProtKB/TrEMBL
  Sushi/SCR/CCP_sf UniProtKB/TrEMBL
  Sushi_SCR_CCP_dom UniProtKB/TrEMBL
NCBI Gene CD46 ENTREZGENE
PANTHER COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING UniProtKB/TrEMBL
  MEMBRANE COFACTOR PROTEIN UniProtKB/TrEMBL
Pfam Sushi UniProtKB/TrEMBL
PIRSF TLX_CD46 UniProtKB/TrEMBL
PROSITE SUSHI UniProtKB/TrEMBL
SMART CCP UniProtKB/TrEMBL
Superfamily-SCOP SSF57535 UniProtKB/TrEMBL
UniProt A0A0D9RRP8 ENTREZGENE, UniProtKB/TrEMBL