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Gene: Slco1b2 (solute carrier organic anion transporter family member 1B2) Rattus norvegicus
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Symbol: Slco1b2
Name: solute carrier organic anion transporter family member 1B2
Description: Exhibits bile acid transmembrane transporter activity and oligopeptide transmembrane transporter activity. Involved in several processes, including bile acid and bile salt transport; response to glucocorticoid; and response to lipopolysaccharide. Localizes to the basolateral plasma membrane. Biomarker of cholestasis. Human ortholog(s) of this gene implicated in bilirubin metabolic disorder. Orthologous to several human genes including SLCO1B3 (solute carrier organic anion transporter family member 1B3); PARTICIPATES IN multispecific organic anion transporter mediated transport pathway; docetaxel pharmacodynamics pathway; mycophenolic acid pharmacokinetics pathway; INTERACTS WITH (+)-schisandrin B; 1-benzylpiperazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: liver-specific organic anion transporter 1; liver-specific transporter-1; OATP-4; Oatp4; organic anion transporting polypeptide 4; rlst-1; Slc21a10; Slco1b3; sodium-independent organic anion-transporting polypeptide 4; solute carrier family (organic anion transporter) member 10; solute carrier family 21 (organic anion transporter) member 10; solute carrier family 21 member 10; solute carrier family 21, member 10; solute carrier organic anion transporter family, member 1B2; solute carrier organic anion transporter family, member 1b3
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.04175,814,118 - 175,881,775 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4175,814,118 - 175,881,768 (+)Ensembl
Rnor_5.04240,035,313 - 240,103,015 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44179,045,586 - 179,118,680 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14179,290,709 - 179,363,804 (+)NCBI
Celera4163,091,969 - 163,159,409 (+)NCBICelera
Cytogenetic Map4q44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Slco1b2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69300
Created: 2001-11-14
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.