Slco1b2 (solute carrier organic anion transporter family member 1B2) - Rat Genome Database

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Gene: Slco1b2 (solute carrier organic anion transporter family member 1B2) Rattus norvegicus
Analyze
Symbol: Slco1b2
Name: solute carrier organic anion transporter family member 1B2
RGD ID: 69300
Description: Enables bile acid transmembrane transporter activity and oligopeptide transmembrane transporter activity. Involved in several processes, including bile acid and bile salt transport; response to glucocorticoid; and response to lipopolysaccharide. Located in basolateral plasma membrane. Used to study bilirubin metabolic disorder. Biomarker of cholestasis. Human ortholog(s) of this gene implicated in bilirubin metabolic disorder and gastrointestinal stromal tumor. Orthologous to several human genes including SLCO1B3 (solute carrier organic anion transporter family member 1B3); PARTICIPATES IN multispecific organic anion transporter mediated transport pathway; docetaxel pharmacodynamics pathway; mycophenolic acid pharmacokinetics pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: liver-specific organic anion transporter 1; liver-specific transporter-1; OATP-4; Oatp4; organic anion transporting polypeptide 4; rlst-1; Slc21a10; Slco1b3; sodium-independent organic anion-transporting polypeptide 4; solute carrier family (organic anion transporter) member 10; solute carrier family 21 (organic anion transporter) member 10; solute carrier family 21 member 10; solute carrier family 21, member 10; solute carrier organic anion transporter family, member 1B2; solute carrier organic anion transporter family, member 1b3
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Allele / Splice: Slco1b2em1Myliu
Genetic Models: SD-Slco1b2em1Myliu
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84176,282,577 - 176,355,557 (+)NCBIGRCr8
mRatBN7.24174,551,463 - 174,619,988 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4174,551,480 - 174,619,981 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4180,846,372 - 180,914,882 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04176,630,650 - 176,699,160 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04175,251,175 - 175,319,685 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04175,814,118 - 175,881,775 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4175,814,118 - 175,881,768 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04240,035,313 - 240,103,015 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44179,045,586 - 179,118,680 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14179,290,709 - 179,363,804 (+)NCBI
Celera4163,091,969 - 163,159,409 (+)NCBICelera
Cytogenetic Map4q44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
(S)-naringenin  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP)
17beta-estradiol 17-glucosiduronic acid  (EXP,ISO)
2,2',4,4',5,6'-Hexabromodiphenyl ether  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
8-(4-chlorophenylthio)-cAMP  (ISO)
acetamide  (EXP)
acetamiprid  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
allopurinol  (ISO)
allyl alcohol  (ISO)
alpha-amanitin  (ISO)
ammonium chloride  (EXP)
apigenin  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atorvastatin  (ISO)
atorvastatin calcium  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
bromosulfophthalein  (ISO)
budesonide  (ISO)
buta-1,3-diene  (ISO)
C60 fullerene  (EXP)
cabazitaxel  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
cefalotin  (ISO)
celecoxib  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
cholic acid  (ISO)
choline  (EXP,ISO)
ciprofibrate  (ISO)
ciprofloxacin  (ISO)
cisplatin  (ISO)
clarithromycin  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
clopidogrel  (ISO)
clozapine  (ISO)
cobalt dichloride  (EXP,ISO)
Cyanoginosin  (ISO)
cyazofamid  (ISO)
cyclosporin A  (ISO)
dehydroepiandrosterone sulfate  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (EXP,ISO)
digoxin  (ISO)
dioscin  (EXP)
donepezil hydrochloride  (ISO)
DPDPE  (EXP)
emodin  (ISO)
endosulfan  (EXP)
epyrifenacil  (EXP,ISO)
erythromycin A  (ISO)
erythromycin estolate  (EXP)
estrone 3-sulfate  (ISO)
Fexofenadine hydrochloride  (ISO)
fluorescein (lactone form)  (ISO)
fluoxetine  (ISO)
flutamide  (EXP)
fluvastatin  (ISO)
furan  (EXP)
fusidic acid  (EXP,ISO)
ginsenoside Rb1  (ISO)
ginsenoside Rc  (ISO)
ginsenoside Rd  (ISO)
ginsenoside Re  (EXP,ISO)
ginsenoside Rg1  (EXP,ISO)
glafenine  (EXP)
glimepiride  (ISO)
glyburide  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
GW 4064  (ISO)
hydroxyurea  (ISO)
ibuprofen  (ISO)
icariin  (ISO)
imipenem hydrate  (ISO)
imipramine  (ISO)
indometacin  (EXP)
indoxyl sulfate  (ISO)
kaempferol  (ISO)
L-methionine  (EXP,ISO)
lead diacetate  (ISO)
levofloxacin  (ISO)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (ISO)
mesalamine  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
microcystin  (ISO)
microcystin LF  (ISO)
microcystin-LR  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
naringin  (ISO)
nateglinide  (ISO)
neomycin  (ISO)
nimesulide  (EXP)
nitrofen  (EXP)
notoginsenoside R1  (EXP,ISO)
obeticholic acid  (EXP,ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oleanolic acid  (ISO)
olmesartan  (ISO)
oltipraz  (ISO)
oroxylin A  (ISO)
oxycodone  (EXP)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorobutanesulfonic acid  (EXP,ISO)
perfluorodecanoic acid  (ISO)
perfluorohexanesulfonic acid  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phalloidin  (ISO)
phenobarbital  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
pravastatin  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
primidone  (ISO)
probenecid  (ISO)
pyrazinecarboxamide  (EXP)
quercetin  (ISO)
Repaglinide  (ISO)
rifampicin  (ISO)
rifamycin SV  (ISO)
ritonavir  (ISO)
rosuvastatin calcium  (EXP,ISO)
rutin  (ISO)
senecionine  (EXP,ISO)
sincalide  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP)
spironolactone  (ISO)
tamoxifen  (ISO)
taurocholic acid  (EXP,ISO)
temozolomide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
theophylline  (EXP,ISO)
thioacetamide  (EXP)
ticlopidine  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
Triptolide  (ISO)
trospium chloride  (ISO)
trovafloxacin  (ISO)
ursodeoxycholic acid  (EXP,ISO)
valproic acid  (ISO)
valsartan  (ISO)
vancomycin  (ISO)
warfarin  (ISO)
zafirlukast  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Characterization of Liver- and Cancer-type-Organic Anion Transporting Polypeptide (OATP) 1B3 Messenger RNA Expression in Normal and Cancerous Human Tissues. Alam K, etal., Drug Metab Lett. 2018;12(1):24-32. doi: 10.2174/1872312812666180326110146.
2. Effect of aminoguanidine on lipopolysaccharide-induced changes in rat liver transporters and transcription factors. Aoki K, etal., Biol Pharm Bull. 2008 Mar;31(3):412-20.
3. Chemically induced mouse liver tumors are resistant to treatment with atorvastatin. Braeuning A, etal., BMC Cancer. 2014 Oct 15;14:766. doi: 10.1186/1471-2407-14-766.
4. Identification of organic anion transporting polypeptide 4 (Oatp4) as a major full-length isoform of the liver-specific transporter-1 (rlst-1) in rat liver. Cattori V, etal., FEBS Lett 2000 Jun 2;474(2-3):242-5.
5. Low expression of organic anion-transporting polypeptide 1B3 predicts a poor prognosis in hepatocellular carcinoma. Chen S, etal., World J Surg Oncol. 2020 Jun 13;18(1):127. doi: 10.1186/s12957-020-01891-y.
6. Cloning of the full-length coding sequence of rat liver-specific organic anion transporter-1 (rlst-1) and a splice variant and partial characterization of the rat lst-1 gene. Choudhuri S, etal., Biochem Biophys Res Commun 2000 Jul 21;274(1):79-86.
7. Determination of transcription start site and analysis of promoter sequence, splice junction sites, intron sequence and codon usage bias of rat liver-specific organic anion transporter-1 (rlst-1/Oatp-4/Slc21a10) gene. Choudhuri S, etal., DNA Seq 2002 Apr;13(2):103-7.
8. Obstructive cholestasis induces TNF-alpha- and IL-1 -mediated periportal downregulation of Bsep and zonal regulation of Ntcp, Oatp1a4, and Oatp1b2. Donner MG, etal., Am J Physiol Gastrointest Liver Physiol. 2007 Dec;293(6):G1134-46. Epub 2007 Oct 4.
9. Down-regulation of hepatic transporters for BSP in rats with indomethacin-induced intestinal injury. Fujiyama N, etal., Biol Pharm Bull. 2007 Mar;30(3):556-61.
10. Differential expression of bile salt and organic anion transporters in developing rat liver. Gao B, etal., J Hepatol. 2004 Aug;41(2):201-8.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Hepatobiliary organic anion transporters are differentially regulated in acute toxic liver injury induced by carbon tetrachloride. Geier A, etal., J Hepatol. 2002 Aug;37(2):198-205.
13. Hepatic uptake of cholecystokinin octapeptide by organic anion-transporting polypeptides OATP4 and OATP8 of rat and human liver. Ismair MG, etal., Gastroenterology. 2001 Nov;121(5):1185-90.
14. Molecular characterization and functional regulation of a novel rat liver-specific organic anion transporter rlst-1. Kakyo M, etal., Gastroenterology 1999 Oct;117(4):770-5.
15. The uptake transporter OATP8 expression decreases during multistep hepatocarcinogenesis: correlation with gadoxetic acid enhanced MR imaging. Kitao A, etal., Eur Radiol. 2011 Oct;21(10):2056-66. doi: 10.1007/s00330-011-2165-8. Epub 2011 May 29.
16. Association of genetic polymorphisms in SLCO1B3 and ABCC2 with docetaxel-induced leukopenia. Kiyotani K, etal., Cancer Sci. 2008 May;99(5):967-72. doi: 10.1111/j.1349-7006.2008.00765.x. Epub 2008 Feb 19.
17. Overexpression of OATP1B3 confers apoptotic resistance in colon cancer. Lee W, etal., Cancer Res. 2008 Dec 15;68(24):10315-23. doi: 10.1158/0008-5472.CAN-08-1984.
18. Mechanisms of pH-gradient driven transport mediated by organic anion polypeptide transporters. Leuthold S, etal., Am J Physiol Cell Physiol. 2009 Mar;296(3):C570-82. doi: 10.1152/ajpcell.00436.2008. Epub 2009 Jan 7.
19. The relationship of polymorphisms in ABCC2 and SLCO1B3 with docetaxel pharmacokinetics and neutropenia: CALGB 60805 (Alliance). Lewis LD, etal., Pharmacogenet Genomics. 2013 Jan;23(1):29-33. doi: 10.1097/FPC.0b013e32835b16d8.
20. Characterization of organic anion transporting polypeptide 1b2 knockout rats generated by CRISPR/Cas9: a novel model for drug transport and hyperbilirubinemia disease. Ma X, etal., Acta Pharm Sin B. 2020 May;10(5):850-860. doi: 10.1016/j.apsb.2019.11.007. Epub 2019 Nov 14.
21. Human liver-specific organic anion transporter-2 is a potent prognostic factor for human breast carcinoma. Muto M, etal., Cancer Sci. 2007 Oct;98(10):1570-6. doi: 10.1111/j.1349-7006.2007.00570.x.
22. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
23. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
24. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
25. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
26. Expression of OATP family members in hormone-related cancers: potential markers of progression. Pressler H, etal., PLoS One. 2011;6(5):e20372. doi: 10.1371/journal.pone.0020372. Epub 2011 May 19.
27. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
28. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
29. Use of mRNA expression to detect the induction of drug metabolising enzymes in rat and human hepatocytes. Richert L, etal., Toxicol Appl Pharmacol. 2008 Dec 10.
30. The Chinese Herb Jianpijiedu Contributes to the Regulation of OATP1B2 and ABCC2 in a Rat Model of Orthotopic Transplantation Liver Cancer Pretreated with Food Restriction and Diarrhea. Sun B, etal., Biomed Res Int. 2015;2015:752850. doi: 10.1155/2015/752850. Epub 2015 Nov 17.
31. Increased estrogen sulfation of estradiol 17beta-D-glucuronide in metastatic tumor rat livers. Sun H, etal., J Pharmacol Exp Ther. 2006 Nov;319(2):818-31. Epub 2006 Aug 8.
32. Unique expression features of cancer-type organic anion transporting polypeptide 1B3 mRNA expression in human colon and lung cancers. Sun Y, etal., Clin Transl Med. 2014 Nov 18;3:37. doi: 10.1186/s40169-014-0037-y. eCollection 2014.
33. Kupffer cell-mediated downregulation of hepatic transporter expression in rat hepatic ischemia-reperfusion. Tanaka Y, etal., Transplantation. 2006 Jul 27;82(2):258-66.
34. OATP1B1 and tumour OATP1B3 modulate exposure, toxicity, and survival after irinotecan-based chemotherapy. Teft WA, etal., Br J Cancer. 2015 Mar 3;112(5):857-65. doi: 10.1038/bjc.2015.5. Epub 2015 Jan 22.
35. Genetic polymorphisms in angiogenesis-related genes are associated with worse progression-free survival of patients with advanced gastrointestinal stromal tumours treated with imatinib. Verboom MC, etal., Eur J Cancer. 2017 Nov;86:226-232. doi: 10.1016/j.ejca.2017.09.025. Epub 2017 Oct 18.
36. Kinetic analysis of saturable hepatic uptake of digoxin and its inhibition by rifampicin. Weiss M, etal., Eur J Pharm Sci. 2008 Aug 7;34(4-5):345-50. Epub 2008 Jun 3.
37. Hormonal regulation of hepatic organic anion transporting polypeptides. Wood M, etal., Mol Pharmacol. 2005 Jul;68(1):218-25. Epub 2005 Apr 19.
Additional References at PubMed
PMID:11713643   PMID:16396499   PMID:17845533   PMID:21812443  


Genomics

Comparative Map Data
Slco1b2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84176,282,577 - 176,355,557 (+)NCBIGRCr8
mRatBN7.24174,551,463 - 174,619,988 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4174,551,480 - 174,619,981 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4180,846,372 - 180,914,882 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04176,630,650 - 176,699,160 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04175,251,175 - 175,319,685 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04175,814,118 - 175,881,775 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4175,814,118 - 175,881,768 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04240,035,313 - 240,103,015 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44179,045,586 - 179,118,680 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14179,290,709 - 179,363,804 (+)NCBI
Celera4163,091,969 - 163,159,409 (+)NCBICelera
Cytogenetic Map4q44NCBI
SLCO1B3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381220,810,705 - 20,916,911 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1220,810,702 - 20,916,911 (+)EnsemblGRCh38hg38GRCh38
GRCh371220,963,639 - 21,069,845 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361220,854,905 - 20,960,925 (+)NCBINCBI36Build 36hg18NCBI36
Build 341220,859,894 - 20,960,921NCBI
Celera1226,119,013 - 26,224,987 (+)NCBICelera
Cytogenetic Map12p12.2NCBI
HuRef1220,736,680 - 20,842,844 (+)NCBIHuRef
CHM1_11220,929,128 - 21,035,317 (+)NCBICHM1_1
T2T-CHM13v2.01220,689,337 - 20,795,485 (+)NCBIT2T-CHM13v2.0
Slco1b2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396141,575,178 - 141,632,372 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6141,575,244 - 141,632,372 (+)EnsemblGRCm39 Ensembl
GRCm386141,629,452 - 141,686,646 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6141,629,518 - 141,686,646 (+)EnsemblGRCm38mm10GRCm38
MGSCv376141,578,039 - 141,635,156 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366141,591,924 - 141,649,041 (+)NCBIMGSCv36mm8
Celera6144,691,211 - 144,748,787 (+)NCBICelera
Cytogenetic Map6G2NCBI
cM Map672.57NCBI
LOC100976982
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21075,893,804 - 75,994,030 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11275,890,201 - 75,990,427 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01265,386,042 - 65,492,240 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11267,987,635 - 68,016,792 (-)NCBIpanpan1.1PanPan1.1panPan2
SLCO1B2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12726,411,008 - 26,496,174 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2726,411,010 - 26,470,989 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2719,984,815 - 20,045,585 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02726,736,938 - 26,822,189 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2726,736,958 - 26,797,155 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12726,599,886 - 26,660,552 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02726,578,617 - 26,645,709 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02719,689,283 - 19,750,093 (+)NCBIUU_Cfam_GSD_1.0
Slco1b3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494587,670,986 - 87,759,281 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365485,593,908 - 5,682,187 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLCO1B2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1552,137,454 - 52,206,236 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2555,411,801 - 55,475,930 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLCO1B3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11120,637,429 - 20,760,577 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1120,648,582 - 20,761,161 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606914,391,434 - 14,498,674 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Slco1b2
147 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:230
Count of miRNA genes:100
Interacting mature miRNAs:105
Transcripts:ENSRNOT00000013409, ENSRNOT00000013514
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
1300109Rf13Renal function QTL 133.91renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)4157710145182687754Rat

Markers in Region
D4Wox55  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24174,619,615 - 174,619,907 (+)MAPPERmRatBN7.2
Rnor_6.04175,881,403 - 175,881,694NCBIRnor6.0
Rnor_5.04240,102,643 - 240,102,934UniSTSRnor5.0
RGSC_v3.44179,118,308 - 179,118,599UniSTSRGSC3.4
Celera4163,159,037 - 163,159,328UniSTS
Cytogenetic Map4q44UniSTS


Genetic Models
This gene Slco1b2 is modified in the following models/strains:
SD-Slco1b2em1Myliu    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
8 10 16 50 89 87 57 25 57 6 163 63 30 27 37 30

Sequence


Ensembl Acc Id: ENSRNOT00000013409   ⟹   ENSRNOP00000013409
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4174,551,480 - 174,619,981 (+)Ensembl
Rnor_6.0 Ensembl4175,814,118 - 175,881,768 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000013514   ⟹   ENSRNOP00000013514
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4174,551,480 - 174,619,981 (+)Ensembl
Rnor_6.0 Ensembl4175,814,118 - 175,881,768 (+)Ensembl
RefSeq Acc Id: NM_001270586   ⟹   NP_001257515
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84176,282,584 - 176,351,090 (+)NCBI
mRatBN7.24174,551,480 - 174,619,988 (+)NCBI
Rnor_6.04175,814,118 - 175,881,775 (+)NCBI
Rnor_5.04240,035,313 - 240,103,015 (+)NCBI
Celera4163,091,969 - 163,159,409 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270587   ⟹   NP_001257516
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84176,282,584 - 176,351,090 (+)NCBI
mRatBN7.24174,551,480 - 174,619,988 (+)NCBI
Rnor_6.04175,814,118 - 175,881,775 (+)NCBI
Rnor_5.04240,035,313 - 240,103,015 (+)NCBI
Celera4163,091,969 - 163,159,409 (+)NCBI
Sequence:
RefSeq Acc Id: NM_031650   ⟹   NP_113838
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84176,282,584 - 176,351,090 (+)NCBI
mRatBN7.24174,551,480 - 174,619,988 (+)NCBI
Rnor_6.04175,814,118 - 175,881,775 (+)NCBI
Rnor_5.04240,035,313 - 240,103,015 (+)NCBI
RGSC_v3.44179,045,586 - 179,118,680 (+)RGD
Celera4163,091,969 - 163,159,409 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039108300   ⟹   XP_038964228
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84176,282,577 - 176,355,557 (+)NCBI
mRatBN7.24174,551,463 - 174,619,985 (+)NCBI
RefSeq Acc Id: XM_039108301   ⟹   XP_038964229
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84176,307,937 - 176,355,557 (+)NCBI
mRatBN7.24174,576,832 - 174,619,985 (+)NCBI
RefSeq Acc Id: NP_113838   ⟸   NM_031650
- Peptide Label: isoform 1
- UniProtKB: Q9JHF6 (UniProtKB/Swiss-Prot),   Q9JIM2 (UniProtKB/Swiss-Prot),   Q9QZX8 (UniProtKB/Swiss-Prot),   A6IMP1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257515   ⟸   NM_001270586
- Peptide Label: isoform 2
- UniProtKB: A6IMP2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257516   ⟸   NM_001270587
- Peptide Label: isoform 3
- UniProtKB: A6IMP3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000013514   ⟸   ENSRNOT00000013514
Ensembl Acc Id: ENSRNOP00000013409   ⟸   ENSRNOT00000013409
RefSeq Acc Id: XP_038964228   ⟸   XM_039108300
- Peptide Label: isoform X1
- UniProtKB: Q9QZX8 (UniProtKB/Swiss-Prot),   Q9JHF6 (UniProtKB/Swiss-Prot),   Q9JIM2 (UniProtKB/Swiss-Prot),   A6IMP1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038964229   ⟸   XM_039108301
- Peptide Label: isoform X2
- UniProtKB: A6IMP4 (UniProtKB/TrEMBL)
Protein Domains
Kazal-like   Major facilitator superfamily (MFS) profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QZX8-F1-model_v2 AlphaFold Q9QZX8 1-687 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693480
Promoter ID:EPDNEW_R4003
Type:multiple initiation site
Name:Slco1b2_1
Description:solute carrier organic anion transporter family, member 1B2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04175,814,122 - 175,814,182EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69300 AgrOrtholog
BioCyc Gene G2FUF-42513 BioCyc
Ensembl Genes ENSRNOG00000030538 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000013409 ENTREZGENE
  ENSRNOT00000013409.8 UniProtKB/Swiss-Prot
  ENSRNOT00000013514 ENTREZGENE
  ENSRNOT00000013514.7 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot
InterPro Kazal_dom UniProtKB/Swiss-Prot
  Kazal_dom_sf UniProtKB/Swiss-Prot
  MFS_dom UniProtKB/Swiss-Prot
  MFS_trans_sf UniProtKB/Swiss-Prot
  OATP UniProtKB/Swiss-Prot
KEGG Report rno:58978 UniProtKB/Swiss-Prot
NCBI Gene 58978 ENTREZGENE
PANTHER PTHR11388 UniProtKB/Swiss-Prot
  SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 1B3 UniProtKB/Swiss-Prot
Pfam Kazal_2 UniProtKB/Swiss-Prot
  OATP UniProtKB/Swiss-Prot
PharmGKB SLCO1B3 RGD
PhenoGen Slco1b2 PhenoGen
PROSITE KAZAL_2 UniProtKB/Swiss-Prot
  MFS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000030538 RatGTEx
Superfamily-SCOP SSF100895 UniProtKB/Swiss-Prot
  SSF103473 UniProtKB/Swiss-Prot
UniProt A6IMP1 ENTREZGENE, UniProtKB/TrEMBL
  A6IMP2 ENTREZGENE, UniProtKB/TrEMBL
  A6IMP3 ENTREZGENE, UniProtKB/TrEMBL
  A6IMP4 ENTREZGENE, UniProtKB/TrEMBL
  Q9JHF6 ENTREZGENE
  Q9JIM2 ENTREZGENE
  Q9QZX8 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q9JHF6 UniProtKB/Swiss-Prot
  Q9JIM2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-11-11 Slco1b2  solute carrier organic anion transporter family member 1B2  Slco1b2  solute carrier organic anion transporter family, member 1B2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-09-30 Slco1b2  solute carrier organic anion transporter family, member 1B2  Slco1b3  solute carrier organic anion transporter family, member 1b3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-03-09 Slco1b3  solute carrier organic anion transporter family, member 1b3  Slco1b2  solute carrier organic anion transporter family, member 1b2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Slco1b2  solute carrier organic anion transporter family, member 1b2  Slc21a10  solute carrier family 21, member 10  Symbol and Name updated 1299863 APPROVED
2002-06-10 Slc21a10  solute carrier family 21, member 10      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_homology shows 64% amino acid sequence identity with the human SLC21A6