Cdc25a (cell division cycle 25A) - Rat Genome Database

Name: Cdc25a
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Cdc25a (cell division cycle 25A) Rattus norvegicus

Analyze

Symbol:

Cdc25a

Name:

cell division cycle 25A

RGD ID:

621498

Description:

Enables phosphoprotein phosphatase activity. Involved in G1/S transition of mitotic cell cycle and positive regulation of cholangiocyte proliferation. Predicted to be active in cytoplasm and nucleus. Used to study autosomal recessive polycystic kidney disease. Biomarker of autosomal recessive polycystic kidney disease. Human ortholog(s) of this gene implicated in cervical cancer; prostate cancer; and urinary bladder cancer. Orthologous to human CDC25A (cell division cycle 25A); PARTICIPATES IN cell cycle pathway, mitotic; INTERACTS WITH (+)-schisandrin B; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

cell division cycle 25 homolog A (S. cerevisiae); cell division cycle 25 homolog A (S. pombe); dual specificity phosphatase Cdc25A; M-phase inducer phosphatase 1

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CDC25A (cell division cycle 25A)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Cdc25a (cell division cycle 25A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cdc25a (cell division cycle 25A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CDC25A (cell division cycle 25A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CDC25A (cell division cycle 25A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cdc25a (cell division cycle 25A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CDC25A (cell division cycle 25A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CDC25A (cell division cycle 25A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Cdc25a (cell division cycle 25A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	PPFIA1 (PTPRF interacting protein alpha 1)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	CDC25A (cell division cycle 25A)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Cdc25a (cell division cycle 25A)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cdc25b (cell division cycle 25B)	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	MIH1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cdc-25.2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoInspector\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cdc-25.3	Alliance	DIOPT (Ensembl Compara\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	stg	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	twe	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	cdc25a	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	8	109,864,356 - 109,882,734 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	109,864,478 - 109,882,701 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	115,480,079 - 115,498,174 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	113,679,257 - 113,697,352 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	111,522,054 - 111,540,149 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	117,953,223 - 117,971,552 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	117,953,444 - 117,971,519 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	117,305,748 - 117,324,074 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	114,237,704 - 114,255,971 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	114,257,158 - 114,275,426 (+)	NCBI
Celera	8	109,154,287 - 109,172,351 (+)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal recessive polycystic kidney disease (IEP,IMP,ISO)

breast carcinoma (ISO)

cervical cancer (ISO)

COVID-19 (ISO)

Experimental Mammary Neoplasms (ISO)

genetic disease (ISO)

Hyperplasia (ISO)

polycystic liver disease (ISO)

Polycystic Liver Disease 1 (ISO)

Progressive Microcephaly with Seizures and Cerebral and Cerebellar Atrophy (ISO)

prostate cancer (ISO)

urinary bladder cancer (ISO)

vulva squamous cell carcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(+)-taxifolin (ISO)

(-)-citrinin (ISO)

(-)-epigallocatechin 3-gallate (ISO)

(20R)-protopanaxadiol (ISO)

(S)-colchicine (ISO)

(S)-naringenin (ISO)

(S)-nicotine (ISO)

1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane (EXP,ISO)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4-(ethoxymethylene)-2-phenyloxazol-5-one (ISO)

4-hydroxynon-2-enal (ISO)

4-hydroxyphenyl retinamide (ISO)

5-aza-2'-deoxycytidine (ISO)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (EXP)

acetylsalicylic acid (ISO)

adenine (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

amiodarone (ISO)

aniline (EXP)

aristolochic acid A (ISO)

Aroclor 1254 (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

atrazine (ISO)

azathioprine (ISO)

bazedoxifene (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[b]fluoranthene (ISO)

bis(2-chloroethyl) sulfide (ISO)

bisphenol A (EXP,ISO)

bosutinib (ISO)

Butylparaben (ISO)

calcitriol (ISO)

cannabidiol (ISO)

carbon nanotube (ISO)

chlorpyrifos (ISO)

chromium(3+) trichloride (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

cocaine (EXP)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

coumestrol (ISO)

cyclosporin A (ISO)

daunorubicin (ISO)

diarsenic trioxide (ISO)

diazinon (EXP)

dibutyl phthalate (ISO)

dichlorvos (EXP)

diethyl maleate (EXP)

dioxygen (ISO)

doxorubicin (EXP,ISO)

Enterolactone (ISO)

entinostat (ISO)

ethanol (ISO)

etoposide (ISO)

fenhexamid (ISO)

fenofibrate (EXP)

folic acid (ISO)

furan (EXP)

gentamycin (EXP)

geraniol (ISO)

glyphosate (ISO)

GW 3965 (ISO)

harmine (ISO)

hydrogen peroxide (ISO)

hydroxytyrosol (ISO)

hydroxyurea (ISO)

Lasiocarpine (ISO)

leptomycin B (ISO)

Licochalcone B (ISO)

lipopolysaccharide (ISO)

metformin (ISO)

methimazole (EXP)

methotrexate (ISO)

methoxychlor (EXP)

methyl methanesulfonate (ISO)

methylparaben (ISO)

methylseleninic acid (ISO)

monocrotaline (ISO)

Muraglitazar (EXP)

N-methyl-4-phenylpyridinium (ISO)

n-propyl gallate (EXP)

nelfinavir (ISO)

nickel atom (ISO)

nickel dichloride (EXP)

nicotine (ISO)

ochratoxin A (ISO)

ozone (ISO)

paclitaxel (ISO)

palbociclib (ISO)

paracetamol (ISO)

paraquat (EXP)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

piroxicam (ISO)

potassium chromate (ISO)

propylparaben (ISO)

resveratrol (EXP,ISO)

riddelliine (ISO)

rotenone (ISO)

silicon dioxide (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium dodecyl sulfate (ISO)

sulfadimethoxine (EXP)

sunitinib (ISO)

tamibarotene (ISO)

tamoxifen (ISO)

teriflunomide (ISO)

Tesaglitazar (EXP)

testosterone (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

thioridazine (ISO)

toluene 2,4-diisocyanate (ISO)

trichloroethene (EXP)

trimellitic anhydride (ISO)

triptonide (ISO)

troglitazone (EXP,ISO)

Tylophorine (ISO)

valproic acid (ISO)

vemurafenib (ISO)

wortmannin (ISO)

zidovudine (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell division (IEA)

cellular response to UV (IEA,ISO)

G1/S transition of mitotic cell cycle (IMP)

G2/M transition of mitotic cell cycle (IBA)

positive regulation of cell cycle G2/M phase transition (IEA)

positive regulation of cholangiocyte proliferation (IMP)

positive regulation of G2/M transition of mitotic cell cycle (IBA)

positive regulation of G2/MI transition of meiotic cell cycle (IBA)

response to radiation (ISO,ISS)

Cellular Component

cytoplasm (IBA,IEA,ISO)

nucleus (IBA,IEA,ISO)

Molecular Function

phosphoprotein phosphatase activity (IDA)

protein binding (ISO)

protein kinase binding (IEA,ISO)

protein tyrosine phosphatase activity (IBA,IEA)

protein-folding chaperone binding (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

cell cycle pathway, mitotic (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Plumbagin, a medicinal plant-derived naphthoquinone, is a novel inhibitor of the growth and invasion of hormone-refractory prostate cancer.	Aziz MH, etal., Cancer Res. 2008 Nov 1;68(21):9024-32.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	p27Kip1 repression of ErbB2-induced mammary tumor growth in transgenic mice involves Skp2 and Wnt/beta-catenin signaling.	Hulit J, etal., Cancer Res. 2006 Sep 1;66(17):8529-41.
5.	Cdc25A is a novel phosphatase functioning early in the cell cycle.	Jinno S, etal., EMBO J 1994 Apr 1;13(7):1549-56.
6.	HYAL1-v1, an alternatively spliced variant of HYAL1 hyaluronidase: a negative regulator of bladder cancer.	Lokeshwar VB, etal., Cancer Res. 2006 Dec 1;66(23):11219-27.
7.	Inhibition of Cdc25A suppresses hepato-renal cystogenesis in rodent models of polycystic kidney and liver disease.	Masyuk TV, etal., Gastroenterology. 2012 Mar;142(3):622-633.e4. doi: 10.1053/j.gastro.2011.11.036. Epub 2011 Dec 7.
8.	Prognostic implication of CDC25A and cyclin E expression on primary breast cancer patients.	Mehdipour P, etal., Cell Biol Int. 2009 Oct;33(10):1050-6. Epub 2009 Jun 23.
9.	Physical and functional interactions between Pim-1 kinase and Cdc25A phosphatase. Implications for the Pim-1-mediated activation of the c-Myc signaling pathway.	Mochizuki T, etal., J Biol Chem 1999 Jun 25;274(26):18659-66.
10.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
11.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
12.	Deregulated CDC25A expression promotes mammary tumorigenesis with genomic instability.	Ray D, etal., Cancer Res. 2007 Feb 1;67(3):984-91.
13.	Hemizygous disruption of Cdc25A inhibits cellular transformation and mammary tumorigenesis in mice.	Ray D, etal., Cancer Res. 2007 Jul 15;67(14):6605-11.
14.	GOA pipeline	RGD automated data pipeline
15.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
16.	Activation of cell cycle regulatory proteins in the apoptosis of terminally differentiated oligodendrocytes.	Strazza M, etal., Neurochem Res. 2004 May;29(5):923-31.
17.	Overexpression of CDC25B, CDC25C and phospho-CDC25C (Ser216) in vulvar squamous cell carcinomas are associated with malignant features and aggressive cancer phenotypes.	Wang Z, etal., BMC Cancer. 2010 May 25;10:233.
18.	Changes in gene expression induced by chemoradiation in advanced cervical carcinoma: a microarray study of RTOG C-0128.	Zempolich K, etal., Gynecol Oncol. 2008 May;109(2):275-9. Epub 2008 Mar 4.

Additional References at PubMed

PMID:11981756	PMID:14742443	PMID:18949056	PMID:19966869	PMID:20813185	PMID:21376736	PMID:22843495	PMID:22899714	PMID:24211536

Genomics

Comparative Map Data

Cdc25a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	8	109,864,356 - 109,882,734 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	109,864,478 - 109,882,701 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	115,480,079 - 115,498,174 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	113,679,257 - 113,697,352 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	111,522,054 - 111,540,149 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	117,953,223 - 117,971,552 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	117,953,444 - 117,971,519 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	117,305,748 - 117,324,074 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	114,237,704 - 114,255,971 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	114,257,158 - 114,275,426 (+)	NCBI
Celera	8	109,154,287 - 109,172,351 (+)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

CDC25A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	48,157,146 - 48,188,417 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	48,157,146 - 48,188,417 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	48,198,636 - 48,229,907 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	48,173,672 - 48,204,805 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	48,173,671 - 48,204,805	NCBI
Celera	3	48,147,668 - 48,178,797 (-)	NCBI		Celera
Cytogenetic Map	3	p21.31	NCBI
HuRef	3	48,253,008 - 48,284,141 (-)	NCBI		HuRef
CHM1_1	3	48,150,488 - 48,181,619 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	48,184,306 - 48,215,830 (-)	NCBI		T2T-CHM13v2.0

Cdc25a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	109,704,545 - 109,722,963 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	109,704,647 - 109,722,963 (+)	Ensembl		GRCm39 Ensembl
GRCm38	9	109,875,518 - 109,893,895 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	109,875,579 - 109,893,895 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	109,778,083 - 109,796,394 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	109,733,366 - 109,751,296 (+)	NCBI		MGSCv36	mm8
Celera	9	109,601,935 - 109,621,511 (+)	NCBI		Celera
Cytogenetic Map	9	F2	NCBI
cM Map	9	59.81	NCBI

Cdc25a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955420	24,344,388 - 24,362,596 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955420	24,345,002 - 24,361,802 (+)	NCBI	ChiLan1.0	ChiLan1.0

CDC25A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	3	48,126,322 - 48,157,503 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	48,068,601 - 48,099,806 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	49,154,307 - 49,186,115 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	49,154,307 - 49,186,115 (-)	Ensembl	panpan1.1		panPan2

CDC25A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	40,823,683 - 40,849,113 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	40,823,459 - 40,847,608 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	40,741,248 - 40,764,940 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	41,309,415 - 41,334,896 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	41,309,419 - 41,334,893 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	40,549,928 - 40,573,619 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	40,951,503 - 40,974,658 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	41,231,962 - 41,255,400 (+)	NCBI		UU_Cfam_GSD_1.0

Cdc25a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	202,108,272 - 202,130,970 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936596	1,659,159 - 1,678,788 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936596	1,657,411 - 1,680,109 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CDC25A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa10.2	13	34,164,323 - 34,190,078 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CDC25A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	9,534,114 - 9,564,927 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	9,534,053 - 9,564,741 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	157,537,318 - 157,569,097 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cdc25a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	73,443,731 - 73,464,486 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624730	73,443,895 - 73,463,979 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Cdc25a
77 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	458
Count of miRNA genes:	230
Interacting mature miRNAs:	279
Transcripts:	ENSRNOT00000028141
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1581557	Eae16	Experimental allergic encephalomyelitis QTL 16	3.8		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	8	8462195	110921472	Rat
631650	Stl6	Serum triglyceride level QTL 6	4	0.0019	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	10378157	112202585	Rat
1554321	Bmd3	Bone mineral density QTL 3	7.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	40952565	123900184	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	46531639	119088626	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	8	46531639	119088626	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	8	46531639	119088626	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	46531639	119088626	Rat
2303171	Bp331	Blood pressure QTL 331	5.57	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	61290298	119084929	Rat
631653	Bp125	Blood pressure QTL 125	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	66142385	111142385	Rat
631210	Bw3	Body weight QTL3	5.9		mesenteric fat pad mass (VT:0010427)	mesenteric fat pad weight to body weight ratio (CMO:0000654)	8	69349194	112783834	Rat
1300171	Bp184	Blood pressure QTL 184	3.66		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	8	70513503	118219066	Rat
8694446	Bw170	Body weight QTL 170	12.07	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	8	71888757	116888757	Rat
9590292	Uminl3	Urine mineral level QTL 3	3.62	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	8	71888757	116888757	Rat
8694200	Abfw4	Abdominal fat weight QTL 4	9.07	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	8	71888757	116888757	Rat
8694392	Bw161	Body weight QTL 161	8.06	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	8	71888757	116888757	Rat
1549909	Stresp11	Stress response QTL 11	6.83	0.0019	stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	8	73473045	118473045	Rat
2300181	Bmd55	Bone mineral density QTL 55	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	76468691	121468691	Rat
61437	Cia6	Collagen induced arthritis QTL 6			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	8	82460758	122812818	Rat
2313400	Anxrr25	Anxiety related response QTL 25			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	8	89265192	114019816	Rat
738011	Anxrr9	Anxiety related response QTL 9	6.1		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	8	93535351	123900184	Rat
1358893	Bp263	Blood pressure QTL 263	5.01		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	93965141	123900184	Rat
1358903	Bp252	Blood pressure QTL 252	7	0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	93965141	123900184	Rat
738014	Anxrr15	Anxiety related response QTL 15	3.6	0.005	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	8	95718998	123900184	Rat
2300182	Bmd56	Bone mineral density QTL 56	5.4		femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	95718998	123900184	Rat
724539	Cm19	Cardiac mass QTL 19	2.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	8	100149864	120994388	Rat

Markers in Region

RH142287

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	8	q32	UniSTS

BF386976

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	109,879,927 - 109,880,082 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	117,968,743 - 117,968,897	NCBI	Rnor6.0
Rnor_5.0	8	117,321,265 - 117,321,419	UniSTS	Rnor5.0
RGSC_v3.4	8	114,253,197 - 114,253,351	UniSTS	RGSC3.4
Celera	8	109,169,597 - 109,169,751	UniSTS
RH 3.4 Map	8	1115.79	UniSTS
Cytogenetic Map	8	q32	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	28	32	24	15	24			55	31	39	3
Low		15	25	17	4	17	8	11	19	4	2	8	8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_133571	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006243702	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006243703	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039080745	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY724516	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D16236	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000200	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000028141 ⟹ ENSRNOP00000028141

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	109,864,758 - 109,882,701 (+)	Ensembl
Rnor_6.0 Ensembl	8	117,953,444 - 117,971,519 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000116348 ⟹ ENSRNOP00000082319

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	109,864,478 - 109,881,103 (+)	Ensembl

RefSeq Acc Id:

NM_133571 ⟹ NP_598255

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	109,864,591 - 109,882,701 (+)	NCBI
Rnor_6.0	8	117,953,444 - 117,971,519 (+)	NCBI
Rnor_5.0	8	117,305,748 - 117,324,074 (+)	NCBI
RGSC_v3.4	8	114,237,704 - 114,255,971 (+)	RGD
Celera	8	109,154,287 - 109,172,351 (+)	RGD

Sequence:

show sequence

CTCGCGGGACACAGAGAGAGAAGCACCGGTGCTTGTGCCTGGCGCCTGCCGAGTCCCCGACGCT
CGCCCGTCCGCGCCGCTGCCCGTGGCGGCCGCGTCTCTGAACCGCGGGGTCGTGTTTGTGTTTG
ACCCGCGGGCGCTGGCGCGTGGCACGGGCTGAAGCGTGCAGCGGGGCGGGGGCCGGCGCACGGA
GGCGGAGGAAGACGAGCGGGAGTCCGGGCAGGCCCGGCGGCGCCATGGAACTGGGCCCGGAGCC
CCCCCACCGCCGCCGCCTGCTCTTCACTTGCAGCCCCACTCCTGCGCCGCAGCCCACGGGGAAG
GTGCAGTTTGGCGCGTCACGTGCTGGCGGACTGTCCCCTGTCACCAACCTGACGGTCACCATGG
ACCAGCTGGAAGGGCTGGGCAGTGACTATGAGAAACCAATGGACGTGAGAAATAGCAGCAGTCT
ACAGAGAATGGGCTCCTCTGAATCGACTGATTCAGGTTTCTGTCTAGATTCTCCTGGGCCCTTG
GACAGTAAAGAAAACCTTGAAATTTCCCTGAGGAGAATAAATTGCCTACCTCAGAAGCTCTTGG
GGTGTAGCCCAGCGCTAAAGAGGAGCCATTCTGATTCTCTAGACCACGACATCTTTCAACTCAT
TGACCAGGATGAAAATAAAGAAAATGAAGCATTTGAATTTAAAAAGCCAATAAGACCTGCATCT
CGTGGCTGCCTGAATGCTCACGTTCACGAGGAAAGTAAGGACCCCTTTACACACAGGCAGAATT
CAGCCCCAGCTCGGATGCTGTCTTCAAATGAAAGTGACATTAGTGAATCAGGAAATTTCAGTCC
TCTTTTTACACCCCAGTCACCTGTGAAAGCGAGTTTGTCTGATGAGGATGATGGCTTCATAGAC
CTTCTGGATGGAGAGAATCTGAAGAATGATGAGGAGACCCCGTCGTGCATGTCAAGCCTCTGGA
CCGCTCCCCTTGTCATGAGAAGACCTACAAACCTTGCCGATCGATGTGGACTGTTTGACTCCCC
TTCCCCGTGCAGCTCCACCAGCAGCTGCAGCACTCGGGCAGTGAAGAGAGCAGACCGATCTCAT
GAGGAGTCTCCTCGAGGTACAAAGCGGAGGAAGAGCAGTGAGGCCAGTCCAGTGAAGGCAGATG
TTCCGGAGCCAACGCAGCTTCCACACCAGTCTCTCTCCCTGACATCTTTCCCCAAAGGAACCAT
TGAGAACATTTTCCACAGTGACCCAAGAGACCTTATAGGGGATTTCTCCAAGGGTTACCTCTTT
CATACGGTCTCTGGGAAGCATCAGGATTTGAAATATATTTCTCCAGAAATTATGGCATCTGTTT
TGAATGGCAAGTTTGCCAATCTCATTAAAGAGTTTGTTATCATTGACTGCCGATACCCATATGA
ATATGAAGGAGGGCACATCAAGGGTGCCGTGAACTTGCACATGGAAGAAGAGGTTGAGGAGTTC
TTACTCAAGAAACCTATCGTGCCCGCTGACGGCAAGCGTGTCATTGTCGTGTTCCACTGTGAGT
TCTCCTCTGAGAGAGGCCCTCGGATGTGCCGATATGTACGGGAACGAGATAGGCTTGGCAATGA
ATACCCCAAACTCCACTACCCTGAGCTGTATGTCCTGAAGGGGGGATACAAGGAGTTCTTTTTG
AAATGCCAGTCTCACTGTGAACCCCCCAGCTACCGACCGATGCACCATGAAGACTTTAAAGAAG
ACCTAAAGAAGTTCCGCACCAAGAGCCGGACCTGGGCAGGGGAGAAGAGCAAAAGGGAGATGTA
CAGTCGCCTGAAGAAGCTTTGAGGCCAAATGGCAGTGACCTGAGCTTCCCTCCGCCCTGTCCCT
TTGTCCCTTTGCTGTAGAGCAGTAAGCAAAGGGGCCAGCTATACGGCACCTGGACCCTGGAGAA
AAACCTGGGCCTTCCATGCCTTGAACCTCCTACACTCCCAGGTTGGAGCCCAGGCATCCTGCCG
TCACACTCTTCTGTGAGAGTCCTTCCCTGTCAGGACTGTCTGCCAAAGCTGGACAAGCTCGGCA
CAGGCTGGCACAGGCTCGAGTCTAGTCTGGAACGCCACGTCAGGCTGCTCCGACTAAGCATCCC
CTGAAGAAGTGCCCAGGCCTCTCATGAGGGGAGAGAAGCCACTGAAGTGCTGCTGGCCAAATAC
CAAAGATAGGCTGGAAGGGGAGAGGTCCTCATGGATGACTCTTTAATTTATTCAGCCTCATCAA
TTATTTTATTATTGTTTTAATTCCTCAAGACTTTTACTTTACTGCTTCAAAGTCAAAATACTGC
CATTCTAGGTAGAGTTTTATCATCCTAGGAACTACCTCTACTTTTAATTTAAAAAAAAAACATG
GGGCAGGGATAAGAAAAAAGGCAAACCTGTTAAGTGTGGGCAGCGCAAGGAACTCAGTCACCCC
TAGGAGGCGCTGTAGACTGGTATTGCTGCTATTCAAAGTCAAGGACTGAGATGCTGGTCAGAGC
CTGCACCAACCAGATCCAGGCTTGGCTACAGGACATAAGCTAACCTTCCCAGACCTACTTCTGC
CCTTTGTGAGTTCCTTTGGGGAGAGTCTTGTCTGTACTCCTGGTCCCAGGTCCCCGTGACAGTG
ACTGGTGTGGGAGTTGCAGGAAGGCACATCAAGCCACCCCCAGGCCAGTACTGGAATGTTGAAG
TGTACCCCAAGGTGGGAGTGGGGAGGCATGGAAAAGTGGAGTCCACAGAGTAAGGGAGGAGCAT
GCCCACTGAATGTCCTTTAGAAAAAAAAAAAAGTCATTTTATGAGTCAGAGTATCCAATCAGTG
TTGGGTGGGCACCTAAGCTTGAGCAGGGGGCGGGAAGCCCGGGCTGTTACAGACGACTGTAGAA
TTTCTCAGGAGGGCGTAGTAAATTTTGAAGTCAAAAGTTCTGGGTTTCATCATGTTTTAATTGA
GGGACAGAGTGGTGAAACACATCAGTTACCCCCTAATCTAACCCCGTGGAAGTGAGGCTCTGGG
GAATGCCTCCCATCTAAGGAGCTGGCCCGTTTTGATTCTGTCAGTGTCCTCGGGCACCAGCCTC
CCTGCCATCTGTGCTCCATTGGGGTCATGCCAGGTTTTTCTTAGGAAGAGTCTCCCCTCTTAAC
CTCTGCTTTCTATTCTGGGGGTGGGGAGGGAATCAATGATATTGAAGATGGCTAGTTGCTTTGT
TAAGGGTTTGAGTTTGCATTTGGCTATAAAACAAATCTTGTTAAAAATATGTGGAGAGCAAGGG
AATGAGCAGCCTCTTCTTCGGTGTGTTGAAGTATGTCCTAGTTTTCCCCTGGTCTGGTTTGTAG
AGATTCTGTTAGTTGAATGCCTTCAAGGAGAATGAATGGCTTTCAGATTGTACCAGCTTAGCTA
GCATTGTTAACCAGCTGCTGCAG

hide sequence

RefSeq Acc Id:

XM_006243702 ⟹ XP_006243764

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	109,864,356 - 109,882,734 (+)	NCBI
Rnor_6.0	8	117,953,223 - 117,971,552 (+)	NCBI
Rnor_5.0	8	117,305,748 - 117,324,074 (+)	NCBI

Sequence:

show sequence

GGAAGGGGCGGGGCGGCGGCTATCCTGAGTGTGCAGCAATTAACGCTAAGGCCACTTTGGTGGT
GAGGGAAGTGGAGGTTCCTTTCCTCTGTGCCGGGTACCGAACGAAGAGGAAGGAAAAAGTGAGG
AGAGTTAGTCCGGTCGGTGGCCTCAAGACTCTGGCTCCGCGGAGTTTGTTTGGATTTAATCTTG
AGGTTGCAGGCGCCCGCCCGCCTACGGGCCTCGCGGGACACAGAGAGAGAAGCACCGGTGCTTG
TGCCTGGCGCCTGCCGAGTCCCCGACGCTCGCCCGTCCGCGCCGCTGCCCGTGGCGGCCGCGTC
TCTGAACCGCGGGGTCGTGTTTGTGTTTGACCCGCGGGCGCTGGCGGCGTGGCACGCGGCTGAA
GCCGGTGCCAGCGGGGCGGGGCCCGGCGCAGCGGAGGCGGAGGAAGACGGAGCGGGAGTCCGGG
CAGGCCCGGCGGCGCCATGGAACTGGGCCCGGAGCCCCCCCACCGCCGCCGCCTGCTCTTCACT
TGCAGCCCCACTCCTGCGCCGCAGCCCACGGGGAAGGTGCTGTTTGGCGCGTCAGCTGCTGGCG
GACTGTCCCCTGTCACCAACCTGACGGTCACCATGGACCAGCTGGAAGGGCTGGGCAGTGACTA
TGAGAAACCAATGGACGTGAGAAATAGCAGCAGTCTACAGAGAATGGGCTCCTCTGAATCGACT
GATTCAGGTTTCTGTCTAGATTCTCCTGGGCCCTTGGACAGTAAAGAAAACCTTGAAATTTCCC
TGAGGAGAATAAATTGCCTACCTAAGCTCTTGGGGTGTAGCCCAGCGCTAAAGAGGAGCCATTC
TGATTCTCTAGACCACGACATCTTTCAACTCATTGACCAGGATGAAAATAAAGAAAATGAAGCA
TTTGAATTTAAAAAGCCAATAAGACCTGCATCTCGTGGCTGCCTGAATGCTCACGTTCACGAGG
AAAGTAAGGACCCCTTTACACACAGGCAGAATTCAGCCCCAGCTCGGATGCTGTCTTCAAATGA
AAGTGACATTAGTGAATCAGGAAATTTCAGTCCTCTTTTTACACCCCAGTCACCTGTGAAAGCC
ACTTTGTCTGATGAGGATGATGGCTTCATAGACCTTCTGGATGGAGAGAATCTGAAGAATGATG
AGGAGACCCCGTCGTGCATGTCAAGCCTCTGGACCGCTCCCCTTGTCATGAGAAGACCTACAAA
CCTTGCCGATCGATGTGGACTGTTTGACTCCCCTTCCCCGTGCAGCTCCACCAGCAGCTGCAGC
ACTCGGGCAGTGAAGAGAGCAGACCGATCTCATGAGGAGTCTCCTCGAGGTACAAAGCGGAGGA
AGAGCAGTGAGGCCAGTCCAGTGAAGGCAGATGTTCCGGAGCCAACGCAGCTTCCACACCAGTC
TCTCTCCCTGACATCTTTCCCCAAAGGAACCATTGAGAACATTTTGGACAGTGACCCAAGAGAC
CTTATAGGGGATTTCTCCAAGGGTTACCTCTTTCATACGGTCTCTGGGAAGCATCAGGATTTGA
AATATATTTCTCCAGAAATTATGGCATCTGTTTTGAATGGCAAGTTTGCCAATCTCATTAAAGA
GTTTGTTATCATTGACTGCCGATACCCATATGAATATGAAGGAGGGCACATCAAGGGTGCCGTG
AACTTGCACATGGAAGAAGAGGTTGAGGAGTTCTTACTCAAGAAACCTATCGTGCCCGCTGACG
GCAAGCGTGTCATTGTCGTGTTCCACTGTGAGTTCTCCTCTGAGAGAGGCCCTCGGATGTGCCG
ATATGTACGGGAACGAGATAGGCTTGGCAATGAATACCCCAAACTCCATTACCCTGAGCTGTAT
GTCCTGAAGGGGGGATACAAGGAGTTCTTTTTGAAATGCCAGTCTCACTGTGAACCCCCCAGCT
ACCGACCGATGCACCATGAAGACTTTAAAGAAGACCTAAAGAAGTTCCGCACCAAGAGCCGGAC
CTGGGCAGGGGAGAAGAGCAAAAGGGAGATGTACAGTCGCCTGAAGAAGCTTTGAGGCCAAATG
GCAGTGACCTGAGCTTCCCTCCGCCCTGTCCCTTTGTCCCTTTGCTGTAGAGCAGTAAGCAAAG
GGGCCAGCTATACGGCACCTGGACCCTGGAGAAAAACCTGGGCCTTCCATGCCTTGAACCTCCT
ACACTCCCAGGTTGGAGCCCAGGGCATCCTGCCGTCACACTCTTCTGTGAGAGTCCTTCCCTGT
CAGGACTGTCTGCCAAAGCTGGACAAGCTCGGCACAGGCTGGCACAGGCTCGAGTCTAGTCTGG
AACGCCACGTCAGGCTACTCCGACTAAGCATCCCCTGAAGAAGTGCCCAGGCCTCTCATGAGGG
GAGAGAAGCCACTGAAGTGCTGCTGGCCAAATACCAAAGATAGGCTGGAAGGGAGAGGTCCTCA
TGGATGACTCTTTAATTTATTCAGCCTCATCAATTATTTTATTATTGTTTTAATTCCTTTTACT
TTTACTTTACTGCTTCAAAGTCAAAATACTGCCATTCTAGGTAGAGTTTTATCATCCTAGGAAC
TACCTCTACTTTTAATTTAAAAAAAAAAAAATGGGGCAGGGATAAGAAAAAAGGCAAACCTGTT
AAGTGTGGGCAGCGCAAGGAACTCAGTCACCCCTAGGAGGCGCTGTAGACTGGTATTGCTGCTA
TTCAAAGTCAAGGACTGAGATGCTGGTCAGAGCCTGCACCAACCAGATCCAGGCTTGGCTACAG
GACATAAGCTAACCTTCCCAGACCTACTTCTGCCCTTTGTGATGTCCTTTGGGGAGAGTCTTGT
CTGTACTCCTGGTCCCAGGTCCCCGTGACAGTGACTGGTGTGGGAGTTGCAGGAAGGCACATCA
AGCCACCCCCAGGCCAGTACTGGAATGTTGAAGTGTACCCCAAGGTGGGAGTGGGGAGGCATGG
AAAAGTGGAGTCCACAGAGTAAGGGAGGAGCATGCCCACTGAATGTCCTTTAGAAAAAAAAAAG
TCATTTTATGAGTCAGAGTATCCAATCAGTGTTGGGTGGGCACCTAAGCGTGAGCAGGGGGCGG
GAAGCCCGGGCTGTTACAGACGACTGTAGAATTTCTCAGGAGGGCGTAGTAAATTTTGAAGTCA
AAAGTTCTGGGTTTATCATGTTTTAATTGAGGGACAGAGTGGTGAAACACATCAGTTACCCCCT
AATCTAACCCCGTGGAAGTGAGGCTCTGGGGAATGCCTCCCATCTAAGGAGCTGGCCCGTTTTG
ATTCTGTCAGTGTCCTCGGGCACCAGCCTCCCTGCCATCTGTGCTCCATTGGGGTCTAGCCAGG
TTTTTCTTAGGAAGAGTCTCCCCTCTTAACCTCTGCTTTCTATTCTGGGGGTGGGGAGGGAATC
AATGATATTGAAGATGGCTAGTTGCTTTGTTAAGGGTTTGAGTTTGCATTTGGCTATAAAACAA
ATCTTGTTAAAAATATGTGGAGAGCAAGGGAATGAGCAGCCTCTTCCCTGGTGTGTTGAAGTAT
GTCCTAGTTGGCCCCTGGTCTGGTTTGTAGAGATTCTGTTAGTTGAATGCCTTCAAGGAGAATG
AATGGCTTTCAGATTGTACCAGCTTAGCTAGCATTGTTAACCAGCTGCTGCAGGCTCTGCAAAT
AAAAGTGAACTTGAACCCATGA

hide sequence

RefSeq Acc Id:

XM_006243703 ⟹ XP_006243765

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	109,864,862 - 109,882,734 (+)	NCBI
Rnor_6.0	8	117,953,764 - 117,971,552 (+)	NCBI
Rnor_5.0	8	117,305,748 - 117,324,074 (+)	NCBI

Sequence:

show sequence

GGGGAAGGTGCTGTTTGGCGCGTCAGCTGCTGGCGGACTGTCCCCTGTCACCAACCTGACGGTC
ACCATGGACCAGCTGGAAGGGCTGGGCAGAAAAGTCTTTGGAATCTACCCTTACGGGGGGAAAA
TGGCCTTCACTACCACTCTTTGCTGAACCACCCGCGTCGGATCTTAGTTTCCTTGACTATGAGA
AACCAATGGACGTGAGAAATAGCAGCAGTCTACAGAGAATGGGCTCCTCTGAATCGACTGATTC
AGGTTTCTGTCTAGATTCTCCTGGGCCCTTGGACAGTAAAGAAAACCTTGAAATTTCCCTGAGG
AGAATAAATTGCCTACCTCAGAAGCTCTTGGGGTGTAGCCCAGCGCTAAAGAGGAGCCATTCTG
ATTCTCTAGACCACGACATCTTTCAACTCATTGACCAGGATGAAAATAAAGAAAATGAAGCATT
TGAATTTAAAAAGCCAATAAGACCTGCATCTCGTGGCTGCCTGAATGCTCACGTTCACGAGGAA
AGTAAGGACCCCTTTACACACAGGCAGAATTCAGCCCCAGCTCGGATGCTGTCTTCAAATGAAA
GTGACATTAGTGAATCAGGAAATTTCAGTCCTCTTTTTACACCCCAGTCACCTGTGAAAGCCAC
TTTGTCTGATGAGGATGATGGCTTCATAGACCTTCTGGATGGAGAGAATCTGAAGAATGATGAG
GAGACCCCGTCGTGCATGTCAAGCCTCTGGACCGCTCCCCTTGTCATGAGAAGACCTACAAACC
TTGCCGATCGATGTGGACTGTTTGACTCCCCTTCCCCGTGCAGCTCCACCAGCAGCTGCAGCAC
TCGGGCAGTGAAGAGAGCAGACCGATCTCATGAGGAGTCTCCTCGAGGTACAAAGCGGAGGAAG
AGCAGTGAGGCCAGTCCAGTGAAGGCAGATGTTCCGGAGCCAACGCAGCTTCCACACCAGTCTC
TCTCCCTGACATCTTTCCCCAAAGGAACCATTGAGAACATTTTGGACAGTGACCCAAGAGACCT
TATAGGGGATTTCTCCAAGGGTTACCTCTTTCATACGGTCTCTGGGAAGCATCAGGATTTGAAA
TATATTTCTCCAGAAATTATGGCATCTGTTTTGAATGGCAAGTTTGCCAATCTCATTAAAGAGT
TTGTTATCATTGACTGCCGATACCCATATGAATATGAAGGAGGGCACATCAAGGGTGCCGTGAA
CTTGCACATGGAAGAAGAGGTTGAGGAGTTCTTACTCAAGAAACCTATCGTGCCCGCTGACGGC
AAGCGTGTCATTGTCGTGTTCCACTGTGAGTTCTCCTCTGAGAGAGGCCCTCGGATGTGCCGAT
ATGTACGGGAACGAGATAGGCTTGGCAATGAATACCCCAAACTCCATTACCCTGAGCTGTATGT
CCTGAAGGGGGGATACAAGGAGTTCTTTTTGAAATGCCAGTCTCACTGTGAACCCCCCAGCTAC
CGACCGATGCACCATGAAGACTTTAAAGAAGACCTAAAGAAGTTCCGCACCAAGAGCCGGACCT
GGGCAGGGGAGAAGAGCAAAAGGGAGATGTACAGTCGCCTGAAGAAGCTTTGAGGCCAAATGGC
AGTGACCTGAGCTTCCCTCCGCCCTGTCCCTTTGTCCCTTTGCTGTAGAGCAGTAAGCAAAGGG
GCCAGCTATACGGCACCTGGACCCTGGAGAAAAACCTGGGCCTTCCATGCCTTGAACCTCCTAC
ACTCCCAGGTTGGAGCCCAGGGCATCCTGCCGTCACACTCTTCTGTGAGAGTCCTTCCCTGTCA
GGACTGTCTGCCAAAGCTGGACAAGCTCGGCACAGGCTGGCACAGGCTCGAGTCTAGTCTGGAA
CGCCACGTCAGGCTACTCCGACTAAGCATCCCCTGAAGAAGTGCCCAGGCCTCTCATGAGGGGA
GAGAAGCCACTGAAGTGCTGCTGGCCAAATACCAAAGATAGGCTGGAAGGGAGAGGTCCTCATG
GATGACTCTTTAATTTATTCAGCCTCATCAATTATTTTATTATTGTTTTAATTCCTTTTACTTT
TACTTTACTGCTTCAAAGTCAAAATACTGCCATTCTAGGTAGAGTTTTATCATCCTAGGAACTA
CCTCTACTTTTAATTTAAAAAAAAAAAAATGGGGCAGGGATAAGAAAAAAGGCAAACCTGTTAA
GTGTGGGCAGCGCAAGGAACTCAGTCACCCCTAGGAGGCGCTGTAGACTGGTATTGCTGCTATT
CAAAGTCAAGGACTGAGATGCTGGTCAGAGCCTGCACCAACCAGATCCAGGCTTGGCTACAGGA
CATAAGCTAACCTTCCCAGACCTACTTCTGCCCTTTGTGATGTCCTTTGGGGAGAGTCTTGTCT
GTACTCCTGGTCCCAGGTCCCCGTGACAGTGACTGGTGTGGGAGTTGCAGGAAGGCACATCAAG
CCACCCCCAGGCCAGTACTGGAATGTTGAAGTGTACCCCAAGGTGGGAGTGGGGAGGCATGGAA
AAGTGGAGTCCACAGAGTAAGGGAGGAGCATGCCCACTGAATGTCCTTTAGAAAAAAAAAAGTC
ATTTTATGAGTCAGAGTATCCAATCAGTGTTGGGTGGGCACCTAAGCGTGAGCAGGGGGCGGGA
AGCCCGGGCTGTTACAGACGACTGTAGAATTTCTCAGGAGGGCGTAGTAAATTTTGAAGTCAAA
AGTTCTGGGTTTATCATGTTTTAATTGAGGGACAGAGTGGTGAAACACATCAGTTACCCCCTAA
TCTAACCCCGTGGAAGTGAGGCTCTGGGGAATGCCTCCCATCTAAGGAGCTGGCCCGTTTTGAT
TCTGTCAGTGTCCTCGGGCACCAGCCTCCCTGCCATCTGTGCTCCATTGGGGTCTAGCCAGGTT
TTTCTTAGGAAGAGTCTCCCCTCTTAACCTCTGCTTTCTATTCTGGGGGTGGGGAGGGAATCAA
TGATATTGAAGATGGCTAGTTGCTTTGTTAAGGGTTTGAGTTTGCATTTGGCTATAAAACAAAT
CTTGTTAAAAATATGTGGAGAGCAAGGGAATGAGCAGCCTCTTCCCTGGTGTGTTGAAGTATGT
CCTAGTTGGCCCCTGGTCTGGTTTGTAGAGATTCTGTTAGTTGAATGCCTTCAAGGAGAATGAA
TGGCTTTCAGATTGTACCAGCTTAGCTAGCATTGTTAACCAGCTGCTGCAGGCTCTGCAAATAA
AAGTGAACTTGAACCCATGA

hide sequence

RefSeq Acc Id:

XM_039080745 ⟹ XP_038936673

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	109,864,893 - 109,882,734 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_598255	(Get FASTA)	NCBI Sequence Viewer
	XP_006243764	(Get FASTA)	NCBI Sequence Viewer
	XP_006243765	(Get FASTA)	NCBI Sequence Viewer
	XP_038936673	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAA03761	(Get FASTA)	NCBI Sequence Viewer
	EDL77098	(Get FASTA)	NCBI Sequence Viewer
	EDL77099	(Get FASTA)	NCBI Sequence Viewer
	P48965	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_598255 ⟸ NM_133571

- UniProtKB:

P48965 (UniProtKB/Swiss-Prot), G3V8T0 (UniProtKB/TrEMBL), A6I3C9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MELGPEPPHRRRLLFTCSPTPAPQPTGKVQFGASRAGGLSPVTNLTVTMDQLEGLGSDYEKPMD
VRNSSSLQRMGSSESTDSGFCLDSPGPLDSKENLEISLRRINCLPQKLLGCSPALKRSHSDSLD
HDIFQLIDQDENKENEAFEFKKPIRPASRGCLNAHVHEESKDPFTHRQNSAPARMLSSNESDIS
ESGNFSPLFTPQSPVKASLSDEDDGFIDLLDGENLKNDEETPSCMSSLWTAPLVMRRPTNLADR
CGLFDSPSPCSSTSSCSTRAVKRADRSHEESPRGTKRRKSSEASPVKADVPEPTQLPHQSLSLT
SFPKGTIENIFHSDPRDLIGDFSKGYLFHTVSGKHQDLKYISPEIMASVLNGKFANLIKEFVII
DCRYPYEYEGGHIKGAVNLHMEEEVEEFLLKKPIVPADGKRVIVVFHCEFSSERGPRMCRYVRE
RDRLGNEYPKLHYPELYVLKGGYKEFFLKCQSHCEPPSYRPMHHEDFKEDLKKFRTKSRTWAGE
KSKREMYSRLKKL

hide sequence

RefSeq Acc Id:	XP_006243764 ⟸ XM_006243702
- Peptide Label:	isoform X1
- UniProtKB:	P48965 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MELGPEPPHRRRLLFTCSPTPAPQPTGKVLFGASAAGGLSPVTNLTVTMDQLEGLGSDYEKPMD VRNSSSLQRMGSSESTDSGFCLDSPGPLDSKENLEISLRRINCLPKLLGCSPALKRSHSDSLDH DIFQLIDQDENKENEAFEFKKPIRPASRGCLNAHVHEESKDPFTHRQNSAPARMLSSNESDISE SGNFSPLFTPQSPVKATLSDEDDGFIDLLDGENLKNDEETPSCMSSLWTAPLVMRRPTNLADRC GLFDSPSPCSSTSSCSTRAVKRADRSHEESPRGTKRRKSSEASPVKADVPEPTQLPHQSLSLTS FPKGTIENILDSDPRDLIGDFSKGYLFHTVSGKHQDLKYISPEIMASVLNGKFANLIKEFVIID CRYPYEYEGGHIKGAVNLHMEEEVEEFLLKKPIVPADGKRVIVVFHCEFSSERGPRMCRYVRER DRLGNEYPKLHYPELYVLKGGYKEFFLKCQSHCEPPSYRPMHHEDFKEDLKKFRTKSRTWAGEK SKREMYSRLKKL hide sequence

RefSeq Acc Id:	XP_006243765 ⟸ XM_006243703
- Peptide Label:	isoform X2
- UniProtKB:	P48965 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MDVRNSSSLQRMGSSESTDSGFCLDSPGPLDSKENLEISLRRINCLPQKLLGCSPALKRSHSDS LDHDIFQLIDQDENKENEAFEFKKPIRPASRGCLNAHVHEESKDPFTHRQNSAPARMLSSNESD ISESGNFSPLFTPQSPVKATLSDEDDGFIDLLDGENLKNDEETPSCMSSLWTAPLVMRRPTNLA DRCGLFDSPSPCSSTSSCSTRAVKRADRSHEESPRGTKRRKSSEASPVKADVPEPTQLPHQSLS LTSFPKGTIENILDSDPRDLIGDFSKGYLFHTVSGKHQDLKYISPEIMASVLNGKFANLIKEFV IIDCRYPYEYEGGHIKGAVNLHMEEEVEEFLLKKPIVPADGKRVIVVFHCEFSSERGPRMCRYV RERDRLGNEYPKLHYPELYVLKGGYKEFFLKCQSHCEPPSYRPMHHEDFKEDLKKFRTKSRTWA GEKSKREMYSRLKKL hide sequence

RefSeq Acc Id:

ENSRNOP00000028141 ⟸ ENSRNOT00000028141

RefSeq Acc Id:	XP_038936673 ⟸ XM_039080745
- Peptide Label:	isoform X3

RefSeq Acc Id:

ENSRNOP00000082319 ⟸ ENSRNOT00000116348

Protein Domains

Rhodanese

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P48965-F1-model_v2	AlphaFold	P48965	1-525	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621498	AgrOrtholog
BioCyc Gene	G2FUF-29084	BioCyc
Ensembl Genes	ENSRNOG00000020737	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000028141	ENTREZGENE
	ENSRNOP00000028141.5	UniProtKB/TrEMBL
	ENSRNOP00000082319.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000028141	ENTREZGENE
	ENSRNOT00000028141.8	UniProtKB/TrEMBL
	ENSRNOT00000116348.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.250.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	MPI_Phosphatase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Rhodanese-like_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Rhodanese-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:171102	UniProtKB/Swiss-Prot
NCBI Gene	171102	ENTREZGENE
PANTHER	M-PHASE INDUCER PHOSPHATASE 1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	M-inducer_phosp	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Rhodanese	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Cdc25a	PhenoGen
PRINTS	MPIPHPHTASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	RHODANESE_3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	RHOD	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF52821	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I5ZUR1_RAT	UniProtKB/TrEMBL
	A6I3C8_RAT	UniProtKB/TrEMBL
	A6I3C9	ENTREZGENE, UniProtKB/TrEMBL
	G3V8T0	ENTREZGENE, UniProtKB/TrEMBL
	MPIP1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-01-23	Cdc25a	cell division cycle 25A	Cdc25a	cell division cycle 25 homolog A (S. pombe)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2007-01-29	Bsnd	cell division cycle 25 homolog A (S. pombe)	Cdc25a	cell division cycle 25 homolog A (S. cerevisiae)	Name updated	1299863	APPROVED
2005-01-20	Cdc25a	cell division cycle 25 homolog A (S. cerevisiae)		cell division cycle 25A	Name updated	1299863	APPROVED
2002-08-07	Cdc25a	cell division cycle 25A			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_process	immunodepletion inhibits cell cycle progression from G1 into the S phase	724653

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)