Chrnb3 (cholinergic receptor nicotinic beta 3 subunit) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Chrnb3 (cholinergic receptor nicotinic beta 3 subunit) Rattus norvegicus
Analyze
Symbol: Chrnb3
Name: cholinergic receptor nicotinic beta 3 subunit
RGD ID: 621544
Description: Enables acetylcholine binding activity. Contributes to heterocyclic compound binding activity. Predicted to be involved in several processes, including presynaptic modulation of chemical synaptic transmission; response to nicotine; and synaptic signaling. Part of acetylcholine-gated channel complex. Biomarker of depressive disorder. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; bipolar disorder; cocaine dependence; depressive disorder; and nicotine dependence. Orthologous to human CHRNB3 (cholinergic receptor nicotinic beta 3 subunit); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; INTERACTS WITH (S)-nicotine; acrylamide; bis(2-ethylhexyl) phthalate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cholinergic receptor, nicotinic beta 3; cholinergic receptor, nicotinic, beta 3; cholinergic receptor, nicotinic, beta 3 (neuronal); cholinergic receptor, nicotinic, beta polypeptide 3; neuronal acetylcholine receptor subunit beta-3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81671,411,847 - 71,454,225 (-)NCBIGRCr8
mRatBN7.21664,713,438 - 64,751,360 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1664,714,169 - 64,751,360 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1670,005,948 - 70,034,159 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01673,412,292 - 73,440,503 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01668,649,563 - 68,686,751 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01668,876,442 - 68,913,628 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1668,875,709 - 68,913,628 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01668,502,911 - 68,539,031 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41669,028,625 - 69,069,274 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11669,028,830 - 69,069,480 (-)NCBI
Celera1662,637,536 - 62,674,782 (-)NCBICelera
Cytogenetic Map16q12.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mammalian nicotinic acetylcholine receptors: from structure to function. Albuquerque EX, etal., Physiol Rev. 2009 Jan;89(1):73-120. doi: 10.1152/physrev.00015.2008.
2. CHRNB3 c.-57A>G functional promoter change affects Parkinson's disease and smoking. Bar-Shira A, etal., Neurobiol Aging. 2014 Sep;35(9):2179.e1-6. doi: 10.1016/j.neurobiolaging.2014.03.014. Epub 2014 Mar 20.
3. Beta 3: a new member of nicotinic acetylcholine receptor gene family is expressed in brain. Deneris ES, etal., J Biol Chem 1989 Apr 15;264(11):6268-72.
4. Association of genes coding for the alpha-4, alpha-5, beta-2 and beta-3 subunits of nicotinic receptors with cigarette smoking and nicotine dependence. Etter JF, etal., Addict Behav. 2009 Sep;34(9):772-5. doi: 10.1016/j.addbeh.2009.05.010. Epub 2009 May 22.
5. Formation of oligomers containing the beta3 and beta4 subunits of the rat nicotinic receptor. Forsayeth JR and Kobrin E, J Neurosci. 1997 Mar 1;17(5):1531-8.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rare missense variants in CHRNB3 and CHRNA3 are associated with risk of alcohol and cocaine dependence. Haller G, etal., Hum Mol Genet. 2014 Feb 1;23(3):810-9. doi: 10.1093/hmg/ddt463. Epub 2013 Sep 20.
8. Down-regulation of cholinergic signaling in the habenula induces anhedonia-like behavior. Han S, etal., Sci Rep. 2017 Apr 18;7(1):900. doi: 10.1038/s41598-017-01088-6.
9. Genetic association of bipolar disorder with the β(3) nicotinic receptor subunit gene. Hartz SM, etal., Psychiatr Genet. 2011 Apr;21(2):77-84. doi: 10.1097/YPG.0b013e32834135eb.
10. Genetic association of the CHRNA6 and CHRNB3 genes with tobacco dependence in a nationally representative sample. Hoft NR, etal., Neuropsychopharmacology. 2009 Feb;34(3):698-706. doi: 10.1038/npp.2008.122. Epub 2008 Aug 13.
11. Reward-related genes and personality traits in alcohol-dependent individuals: a pilot case control study. Landgren S, etal., Neuropsychobiology. 2011;64(1):38-46. doi: 10.1159/000324992. Epub 2011 May 24.
12. Nicotinic cholinergic receptors in the rat retina: simple and mixed heteromeric subtypes. Marritt AM, etal., Mol Pharmacol. 2005 Dec;68(6):1656-68. Epub 2005 Aug 29.
13. Expression of acetylcholine receptors by experimental rat renal allografts. Meixner M, etal., Biomed Res Int. 2014;2014:289656. doi: 10.1155/2014/289656. Epub 2014 Jul 9.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Cholinergic receptor nicotinic beta 3 subunit polymorphisms and smoking in male Chinese patients with schizophrenia. Shi J, etal., EC Psychol Psychiatr. 2021;10(7):11-23. Epub 2021 Jun 28.
20. Significant association of the CHRNB3-CHRNA6 gene cluster with nicotine dependence in the Chinese Han population. Wen L, etal., Sci Rep. 2017 Aug 29;7(1):9745. doi: 10.1038/s41598-017-09492-8.
Additional References at PubMed
PMID:14657161   PMID:18266937   PMID:23846688   PMID:24398291  


Genomics

Comparative Map Data
Chrnb3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81671,411,847 - 71,454,225 (-)NCBIGRCr8
mRatBN7.21664,713,438 - 64,751,360 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1664,714,169 - 64,751,360 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1670,005,948 - 70,034,159 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01673,412,292 - 73,440,503 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01668,649,563 - 68,686,751 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01668,876,442 - 68,913,628 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1668,875,709 - 68,913,628 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01668,502,911 - 68,539,031 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41669,028,625 - 69,069,274 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11669,028,830 - 69,069,480 (-)NCBI
Celera1662,637,536 - 62,674,782 (-)NCBICelera
Cytogenetic Map16q12.3NCBI
CHRNB3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38842,697,366 - 42,737,407 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl842,697,366 - 42,737,407 (+)EnsemblGRCh38hg38GRCh38
GRCh37842,552,509 - 42,592,550 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36842,671,719 - 42,711,366 (+)NCBINCBI36Build 36hg18NCBI36
Build 34842,671,718 - 42,711,366NCBI
Celera841,499,567 - 41,540,205 (+)NCBICelera
Cytogenetic Map8p11.21NCBI
HuRef841,074,730 - 41,114,440 (+)NCBIHuRef
CHM1_1842,599,470 - 42,639,116 (+)NCBICHM1_1
T2T-CHM13v2.0842,965,410 - 43,005,503 (+)NCBIT2T-CHM13v2.0
Chrnb3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39827,858,688 - 27,889,758 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl827,858,739 - 27,889,758 (+)EnsemblGRCm39 Ensembl
GRCm38827,368,711 - 27,399,730 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl827,368,711 - 27,399,730 (+)EnsemblGRCm38mm10GRCm38
MGSCv37828,479,183 - 28,510,202 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36828,834,647 - 28,865,665 (+)NCBIMGSCv36mm8
Celera828,858,231 - 28,889,248 (+)NCBICelera
Cytogenetic Map8A2NCBI
cM Map816.0NCBI
Chrnb3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955536190,949 - 232,424 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955536189,881 - 229,835 (-)NCBIChiLan1.0ChiLan1.0
CHRNB3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2761,155,811 - 61,195,012 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1836,871,869 - 36,911,058 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0841,947,062 - 41,987,159 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1839,390,959 - 39,430,267 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl839,391,001 - 39,429,926 (+)Ensemblpanpan1.1panPan2
CHRNB3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11623,021,652 - 23,040,907 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1623,021,645 - 23,048,347 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1623,524,646 - 23,545,471 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01624,771,003 - 24,791,610 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1624,772,988 - 24,791,545 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11623,139,564 - 23,160,813 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01623,704,601 - 23,725,844 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01623,755,352 - 23,776,571 (-)NCBIUU_Cfam_GSD_1.0
Chrnb3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494346,089,677 - 46,116,077 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493678546,796 - 72,640 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493678546,076 - 72,529 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHRNB3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1711,687,557 - 11,722,183 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11711,687,646 - 11,714,357 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21712,667,001 - 12,693,124 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CHRNB3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1840,695,061 - 40,730,127 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl840,706,666 - 40,728,963 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660521,043,203 - 1,065,050 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Chrnb3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624780487,006 - 510,056 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624780481,836 - 510,192 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Chrnb3
403 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:107
Count of miRNA genes:96
Interacting mature miRNAs:104
Transcripts:ENSRNOT00000016656
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat

Markers in Region
PMC18423P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21664,718,406 - 64,719,062 (+)MAPPERmRatBN7.2
Rnor_6.01668,880,679 - 68,881,334NCBIRnor6.0
Rnor_5.01668,507,148 - 68,507,803UniSTSRnor5.0
RGSC_v3.41669,032,862 - 69,033,517UniSTSRGSC3.4
Celera1662,641,773 - 62,642,428UniSTS
Cytogenetic Map16q12.3UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
7 3 11 85 30 32 11 8 11 6 68 34 70 13 44 21

Sequence


Ensembl Acc Id: ENSRNOT00000016656   ⟹   ENSRNOP00000016656
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1664,714,169 - 64,751,360 (-)Ensembl
Rnor_6.0 Ensembl1668,875,709 - 68,913,628 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110724   ⟹   ENSRNOP00000086782
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1664,714,169 - 64,751,360 (-)Ensembl
RefSeq Acc Id: NM_133597   ⟹   NP_598281
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81671,417,039 - 71,454,225 (-)NCBI
mRatBN7.21664,714,169 - 64,751,360 (-)NCBI
Rnor_6.01668,876,442 - 68,913,628 (-)NCBI
Rnor_5.01668,502,911 - 68,539,031 (-)NCBI
RGSC_v3.41669,028,625 - 69,069,274 (-)RGD
Celera1662,637,536 - 62,674,782 (-)RGD
Sequence:
RefSeq Acc Id: XM_039094178   ⟹   XP_038950106
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81671,411,847 - 71,438,853 (-)NCBI
mRatBN7.21664,713,438 - 64,736,011 (-)NCBI
RefSeq Acc Id: XM_039094179   ⟹   XP_038950107
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81671,411,847 - 71,441,648 (-)NCBI
mRatBN7.21664,713,438 - 64,738,736 (-)NCBI
Protein Sequences
Protein RefSeqs NP_598281 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950106 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950107 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC28887 (Get FASTA)   NCBI Sequence Viewer  
  AAS90355 (Get FASTA)   NCBI Sequence Viewer  
  EDM09103 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000016656
  ENSRNOP00000016656.3
GenBank Protein P12391 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_598281   ⟸   NM_133597
- Peptide Label: precursor
- UniProtKB: P12391 (UniProtKB/Swiss-Prot),   A6IVW9 (UniProtKB/TrEMBL),   Q6PW48 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016656   ⟸   ENSRNOT00000016656
RefSeq Acc Id: XP_038950107   ⟸   XM_039094179
- Peptide Label: isoform X1
- UniProtKB: Q6PW48 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038950106   ⟸   XM_039094178
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000086782   ⟸   ENSRNOT00000110724
Protein Domains
Neurotransmitter-gated ion-channel ligand-binding   Neurotransmitter-gated ion-channel transmembrane

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P12391-F1-model_v2 AlphaFold P12391 1-464 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621544 AgrOrtholog
BioCyc Gene G2FUF-11040 BioCyc
Ensembl Genes ENSRNOG00000012448 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000016656 ENTREZGENE
  ENSRNOT00000016656.5 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.58.390 UniProtKB/Swiss-Prot
  2.70.170.10 UniProtKB/Swiss-Prot
InterPro Neur_chan_lig-bd UniProtKB/Swiss-Prot
  Neur_chan_lig-bd_sf UniProtKB/Swiss-Prot
  Neur_channel UniProtKB/Swiss-Prot
  Neuro-gated_channel_TM_sf UniProtKB/Swiss-Prot
  Neuro_actylchol_rec UniProtKB/Swiss-Prot
  Neurotrans-gated_channel_TM UniProtKB/Swiss-Prot
  Neurotransmitter_ion_chnl_CS UniProtKB/Swiss-Prot
  Nicotinic_acetylcholine_rcpt UniProtKB/Swiss-Prot
KEGG Report rno:171131 UniProtKB/Swiss-Prot
NCBI Gene 171131 ENTREZGENE
PANTHER PTHR18945 UniProtKB/Swiss-Prot
Pfam Neur_chan_LBD UniProtKB/Swiss-Prot
  Neur_chan_memb UniProtKB/Swiss-Prot
PhenoGen Chrnb3 PhenoGen
PRINTS NICOTINICR UniProtKB/Swiss-Prot
  NRIONCHANNEL UniProtKB/Swiss-Prot
PROSITE NEUROTR_ION_CHANNEL UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000012448 RatGTEx
Superfamily-SCOP SSF63712 UniProtKB/Swiss-Prot
  SSF90112 UniProtKB/Swiss-Prot
UniProt A0A8I6A6P7_RAT UniProtKB/TrEMBL
  A6IVW9 ENTREZGENE, UniProtKB/TrEMBL
  ACHB3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6PW48 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Chrnb3  cholinergic receptor nicotinic beta 3 subunit  Chrnb3  cholinergic receptor, nicotinic beta 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-12-09 Chrnb3  cholinergic receptor, nicotinic beta 3  Chrnb3  cholinergic receptor, nicotinic, beta 3 (neuronal)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-16 Chrnb3  cholinergic receptor, nicotinic, beta 3 (neuronal)  Chrnb3  cholinergic receptor, nicotinic, beta 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-29 Chrnb3  cholinergic receptor, nicotinic, beta 3  Chrnb3  cholinergic receptor, nicotinic, beta polypeptide 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Chrnb3  cholinergic receptor, nicotinic, beta polypeptide 3      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Chrnb3  cholinergic receptor, nicotinic, beta polypeptide 3      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in brain 724745