Tat (tyrosine aminotransferase) - Rat Genome Database

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Gene: Tat (tyrosine aminotransferase) Rattus norvegicus
Analyze
Symbol: Tat
Name: tyrosine aminotransferase
RGD ID: 3820
Description: Enables L-tyrosine:2-oxoglutarate aminotransferase activity and amino acid binding activity. Involved in several processes, including response to dexamethasone; response to mercury ion; and response to oxidative stress. Human ortholog(s) of this gene implicated in tyrosinemia and tyrosinemia type II. Orthologous to human TAT (tyrosine aminotransferase); PARTICIPATES IN alkaptonuria pathway; disulfiram pharmacodynamics pathway; dopamine beta-hydroxylase deficiency pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate; 11-deoxycorticosterone.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: L-tyrosine:2-oxoglutarate aminotransferase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81954,856,604 - 54,867,168 (+)NCBIGRCr8
mRatBN7.21937,947,153 - 37,957,717 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1937,947,112 - 37,958,031 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1944,759,466 - 44,770,043 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01945,412,802 - 45,423,379 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01947,722,404 - 47,732,988 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01941,675,639 - 41,686,195 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1941,675,355 - 41,686,229 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01952,499,259 - 52,509,759 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41939,854,163 - 39,865,060 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11939,859,002 - 39,870,255 (+)NCBI
Celera1937,350,682 - 37,361,246 (+)NCBICelera
RH 3.4 Map19448.1RGD
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(S)-colchicine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
11-deoxycorticosterone  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2-nitrofluorene  (EXP)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-methyl-4'-dimethylaminoazobenzene  (EXP)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
acephate  (EXP)
acetic acid  (ISO)
actinomycin D  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
aldosterone  (EXP)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (ISO)
atropine  (EXP)
azoxystrobin  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beryllium sulfate  (EXP)
bisphenol A  (EXP,ISO)
bosentan  (ISO)
bromobenzene  (EXP)
bromochloroacetic acid  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
Calcimycin  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP)
clofibrate  (ISO)
corn oil  (EXP)
corticosterone  (EXP)
cortisol  (EXP,ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
cypermethrin  (EXP)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
diazepam  (EXP)
dichlorvos  (EXP)
diethylstilbestrol  (EXP)
disulfiram  (EXP)
ebselen  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP)
folic acid  (ISO)
furan  (EXP)
gentamycin  (EXP)
glyphosate  (EXP)
imidacloprid  (EXP)
inulin  (ISO)
ketoconazole  (ISO)
lead diacetate  (EXP,ISO)
leflunomide  (ISO)
mercury atom  (EXP)
mercury(0)  (EXP)
methapyrilene  (EXP)
methoxychlor  (EXP)
methylprednisolone aceponate  (ISO)
miconazole  (EXP,ISO)
mifepristone  (EXP,ISO)
mirex  (EXP)
mometasone furoate  (ISO)
monosodium L-glutamate  (ISO)
Muraglitazar  (EXP)
N(4)-hydroxycytidine  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
nevirapine  (ISO)
nimesulide  (EXP)
O-methyleugenol  (ISO)
ortho-Aminoazotoluene  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
phorbol 13-acetate 12-myristate  (EXP)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
prednisolone  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sphingosine  (EXP)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tolylfluanid  (EXP)
Triptolide  (EXP,ISO)
triptonide  (ISO)
troglitazone  (EXP)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP)
trovafloxacin  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
withaferin A  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Structural and immunochemical properties of rat liver tyrosine aminotransferase. Dietrich JB, etal., Biochimie 1988 May;70(5):673-9.
2. Mercury influences rat liver tyrosine aminotransferase activity and induction by dexamethasone. Dundjerski J, etal., J Appl Toxicol. 2006 Mar-Apr;26(2):187-90.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Complete complementary DNA of rat tyrosine aminotransferase messenger RNA. Deduction of the primary structure of the enzyme. Grange T, etal., J Mol Biol 1985 Jul 20;184(2):347-50.
6. The structure of tyrosine aminotransferase. Evidence for domains involved in catalysis and enzyme turnover. Hargrove JL, etal., J Biol Chem 1989 Jan 5;264(1):45-53.
7. Role of Glucocorticoid Receptor and Pregnane X Receptor in Dexamethasone Induction of Rat Hepatic Aryl Hydrocarbon Receptor Nuclear Translocator and NADPH-Cytochrome P450 Oxidoreductase. Hunter SR, etal., Drug Metab Dispos. 2017 Feb;45(2):118-129. doi: 10.1124/dmd.116.073833. Epub 2016 Nov 16.
8. Xenobiotics and the glucocorticoid receptor: additive antagonistic effects on tyrosine aminotransferase activity in rat hepatoma cells. Johansson M, etal., Basic Clin Pharmacol Toxicol. 2005 Apr;96(4):309-15.
9. [Glucose-fatty acids cycle in cobalt chloride-induced oxidative stress in rats] Kaliman PA and Okhrimenko SM, Ukr Biokhim Zh. 2005 Mar-Apr;77(2):154-8.
10. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
11. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Subcellular distribution of tyrosine aminotransferase in rat brain. Miller JE and Litwack G, Arch Biochem Biophys. 1969 Oct;134(1):149-59.
14. Point mutations in the tyrosine aminotransferase gene in tyrosinemia type II. Natt E, etal., Proc Natl Acad Sci U S A. 1992 Oct 1;89(19):9297-301.
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
19. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Isolation and characterization of the rat tyrosine aminotransferase gene. Shinomiya T, etal., Proc Natl Acad Sci U S A 1984 Mar;81(5):1346-50.
24. Involvement of conserved asparagine and arginine residues from the N-terminal region in the catalytic mechanism of rat liver and Trypanosoma cruzi tyrosine aminotransferases. Sobrado VR, etal., Protein Sci. 2003 May;12(5):1039-50.
25. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
Additional References at PubMed
PMID:1299072   PMID:1682164   PMID:1983704   PMID:7999802   PMID:12477932   PMID:14651853   PMID:17170234   PMID:21153519   PMID:25502805   PMID:31515488  


Genomics

Comparative Map Data
Tat
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81954,856,604 - 54,867,168 (+)NCBIGRCr8
mRatBN7.21937,947,153 - 37,957,717 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1937,947,112 - 37,958,031 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1944,759,466 - 44,770,043 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01945,412,802 - 45,423,379 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01947,722,404 - 47,732,988 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01941,675,639 - 41,686,195 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1941,675,355 - 41,686,229 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01952,499,259 - 52,509,759 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41939,854,163 - 39,865,060 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11939,859,002 - 39,870,255 (+)NCBI
Celera1937,350,682 - 37,361,246 (+)NCBICelera
RH 3.4 Map19448.1RGD
Cytogenetic Map19q12NCBI
TAT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381671,565,660 - 71,577,092 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1671,565,660 - 71,577,092 (-)EnsemblGRCh38hg38GRCh38
GRCh371671,599,563 - 71,610,995 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361670,158,255 - 70,168,496 (-)NCBINCBI36Build 36hg18NCBI36
Build 341670,158,254 - 70,168,496NCBI
Celera1655,916,606 - 55,926,850 (-)NCBICelera
Cytogenetic Map16q22.2NCBI
HuRef1657,368,735 - 57,378,980 (-)NCBIHuRef
CHM1_11673,013,576 - 73,023,820 (-)NCBICHM1_1
T2T-CHM13v2.01677,382,852 - 77,394,286 (-)NCBIT2T-CHM13v2.0
Tat
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398110,712,710 - 110,726,436 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8110,717,069 - 110,726,435 (+)EnsemblGRCm39 Ensembl
GRCm388109,986,078 - 109,999,804 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8109,990,437 - 109,999,803 (+)EnsemblGRCm38mm10GRCm38
MGSCv378112,514,336 - 112,523,704 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368112,879,586 - 112,888,930 (+)NCBIMGSCv36mm8
Celera8114,212,364 - 114,221,732 (+)NCBICelera
Cytogenetic Map8D3NCBI
cM Map855.2NCBI
Tat
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554844,276,953 - 4,287,627 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554844,278,083 - 4,287,535 (-)NCBIChiLan1.0ChiLan1.0
TAT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21882,583,247 - 82,594,018 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11688,514,074 - 88,524,846 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01653,434,028 - 53,443,624 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11671,402,560 - 71,414,013 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1671,404,399 - 71,413,886 (-)Ensemblpanpan1.1panPan2
TAT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1577,365,589 - 77,378,474 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl577,366,138 - 77,378,419 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha577,327,228 - 77,340,137 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0577,804,675 - 77,817,578 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl577,804,680 - 77,817,500 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1577,624,765 - 77,637,663 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0577,447,892 - 77,460,816 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0577,946,897 - 77,959,805 (-)NCBIUU_Cfam_GSD_1.0
Tat
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934937,389,275 - 37,399,429 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647522,189,728 - 22,199,672 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647522,190,282 - 22,199,398 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TAT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl614,570,589 - 14,583,177 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1614,571,311 - 14,583,203 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2614,064,566 - 14,076,459 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TAT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1554,695,342 - 54,749,291 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl554,693,458 - 54,705,082 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604717,503,474 - 17,512,808 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tat
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474613,790,440 - 13,803,202 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474613,793,593 - 13,803,227 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tat
52 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:132
Count of miRNA genes:102
Interacting mature miRNAs:119
Transcripts:ENSRNOT00000022721
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1354607Gmadr1Adrenal mass QTL 15.83adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)192753020737947399Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)192481797839654489Rat
1354600Salc2Saline consumption QTL 29.910.001drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)192753020737947399Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
1354633Bw28Body weight QTL 286.04body mass (VT:0001259)body weight (CMO:0000012)192753020737947399Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat

Markers in Region
D19Mgh2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21937,955,789 - 37,955,932 (-)MAPPERmRatBN7.2
Rnor_6.01941,677,424 - 41,677,566NCBIRnor6.0
Rnor_5.01952,501,044 - 52,501,186UniSTSRnor5.0
RGSC_v3.41939,863,132 - 39,863,275RGDRGSC3.4
RGSC_v3.41939,863,133 - 39,863,275UniSTSRGSC3.4
RGSC_v3.11939,868,013 - 39,868,156RGD
Celera1937,359,319 - 37,359,461UniSTS
RH 3.4 Map19442.9RGD
RH 3.4 Map19442.9UniSTS
RH 2.0 Map19488.7RGD
FHH x ACI Map1930.2099RGD
Cytogenetic Map19q11-q12UniSTS
D19Wox4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21937,947,207 - 37,947,399 (-)MAPPERmRatBN7.2
Rnor_6.01941,685,949 - 41,686,140NCBIRnor6.0
Rnor_5.01952,509,513 - 52,509,704UniSTSRnor5.0
RGSC_v3.41939,854,217 - 39,854,409RGDRGSC3.4
RGSC_v3.41939,854,218 - 39,854,409UniSTSRGSC3.4
RGSC_v3.11939,859,098 - 39,859,290RGD
Celera1937,350,737 - 37,350,926UniSTS
RH 3.4 Map19441.8UniSTS
RH 3.4 Map19441.8RGD
RH 2.0 Map19482.6RGD
Cytogenetic Map19q11-q12UniSTS
D19Wox6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21937,937,168 - 37,937,490 (-)MAPPERmRatBN7.2
Rnor_6.01941,695,858 - 41,696,179NCBIRnor6.0
Rnor_5.01952,519,422 - 52,519,743UniSTSRnor5.0
RGSC_v3.41939,844,178 - 39,844,500RGDRGSC3.4
RGSC_v3.41939,844,179 - 39,844,500UniSTSRGSC3.4
RGSC_v3.11939,849,059 - 39,849,381RGD
Celera1937,340,698 - 37,341,019UniSTS
RH 3.4 Map19431.7UniSTS
RH 3.4 Map19431.7RGD
RH 2.0 Map19471.8RGD
Cytogenetic Map19q11-q12UniSTS
D19Wox5  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map19454.5UniSTS
RH 3.4 Map19454.5RGD
Cytogenetic Map19q11-q12UniSTS
D19Arb5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21937,947,112 - 37,947,409 (-)MAPPERmRatBN7.2
Rnor_6.01941,685,939 - 41,686,235NCBIRnor6.0
Rnor_5.01952,509,503 - 52,509,799UniSTSRnor5.0
RGSC_v3.41939,854,122 - 39,854,419RGDRGSC3.4
RGSC_v3.41939,854,123 - 39,854,419UniSTSRGSC3.4
RGSC_v3.11939,859,003 - 39,859,300RGD
Celera1937,350,642 - 37,350,936UniSTS
Cytogenetic Map19q11-q12UniSTS
Tat  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21937,947,222 - 37,947,402 (-)MAPPERmRatBN7.2
Rnor_6.01941,685,946 - 41,686,125NCBIRnor6.0
Rnor_5.01952,509,510 - 52,509,689UniSTSRnor5.0
RGSC_v3.41939,854,233 - 39,854,412UniSTSRGSC3.4
Celera1937,350,752 - 37,350,929UniSTS
Cytogenetic Map19q11-q12UniSTS
RH94607  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21937,957,511 - 37,957,647 (-)MAPPERmRatBN7.2
Rnor_6.01941,675,709 - 41,675,844NCBIRnor6.0
Rnor_5.01952,499,329 - 52,499,464UniSTSRnor5.0
RGSC_v3.41939,864,855 - 39,864,990UniSTSRGSC3.4
Celera1937,361,041 - 37,361,176UniSTS
RH 3.4 Map19448.1UniSTS
Cytogenetic Map19q11-q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 87 87 87
Low 10 8 8 8 11 12 11 6
Below cutoff 13 30 101 46 48 46 25 21 78 67 94 38 15

Sequence


Ensembl Acc Id: ENSRNOT00000022721   ⟹   ENSRNOP00000022721
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1937,947,112 - 37,958,031 (+)Ensembl
Rnor_6.0 Ensembl1941,675,355 - 41,686,229 (-)Ensembl
RefSeq Acc Id: NM_012668   ⟹   NP_036800
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81954,856,604 - 54,867,168 (+)NCBI
mRatBN7.21937,947,153 - 37,957,717 (+)NCBI
Rnor_6.01941,675,639 - 41,686,195 (-)NCBI
Rnor_5.01952,499,259 - 52,509,759 (-)NCBI
RGSC_v3.41939,854,163 - 39,865,060 (+)RGD
Celera1937,350,682 - 37,361,246 (+)RGD
Sequence:
RefSeq Acc Id: NP_036800   ⟸   NM_012668
- UniProtKB: Q5EBB6 (UniProtKB/Swiss-Prot),   P04694 (UniProtKB/Swiss-Prot),   A6IZ42 (UniProtKB/TrEMBL),   Q9QWS4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022721   ⟸   ENSRNOT00000022721
Protein Domains
Aminotransferase class I/classII

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P04694-F1-model_v2 AlphaFold P04694 1-454 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701131
Promoter ID:EPDNEW_R11655
Type:single initiation site
Name:Tat_1
Description:tyrosine aminotransferase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01941,686,236 - 41,686,296EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3820 AgrOrtholog
BioCyc Gene G2FUF-5702 BioCyc
BioCyc Pathway PWY-5886 [3-(4-hydroxyphenyl)pyruvate biosynthesis] BioCyc
  TYRFUMCAT-PWY [L-tyrosine degradation I] BioCyc
BioCyc Pathway Image PWY-5886 BioCyc
  TYRFUMCAT-PWY BioCyc
Ensembl Genes ENSRNOG00000016348 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055021389 UniProtKB/Swiss-Prot
  ENSRNOG00060012900 UniProtKB/Swiss-Prot
  ENSRNOG00065012011 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000022721.5 UniProtKB/Swiss-Prot
  ENSRNOT00055036557 UniProtKB/Swiss-Prot
  ENSRNOT00060021944 UniProtKB/Swiss-Prot
  ENSRNOT00065019534 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.640.10 UniProtKB/Swiss-Prot
  3.90.1150.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Type I PLP-dependent aspartate aminotransferase-like (Major domain) UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7372826 IMAGE-MGC_LOAD
InterPro Aminotransferase_I/II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NHTrfase_class1_PyrdxlP-BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_dom1 UniProtKB/Swiss-Prot
  PyrdxlP-dep_Trfase_major UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_small UniProtKB/TrEMBL
  Tyr_aminoTrfase_ubiquitination UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TyrNic_aminoTrfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyrosine_aminoTrfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24813 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:108738 IMAGE-MGC_LOAD
NCBI Gene 24813 ENTREZGENE
PANTHER TYROSINE AMINOTRANSFERASE UniProtKB/Swiss-Prot
  TYROSINE AMINOTRANSFERASE UniProtKB/Swiss-Prot
  TYROSINE AMINOTRANSFERASE UniProtKB/TrEMBL
  TYROSINE AMINOTRANSFERASE UniProtKB/TrEMBL
Pfam Aminotran_1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TAT_ubiq UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tat PhenoGen
PIRSF Tyr_transaminase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE AA_TRANSFER_CLASS_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016348 RatGTEx
  ENSRNOG00055021389 RatGTEx
  ENSRNOG00060012900 RatGTEx
  ENSRNOG00065012011 RatGTEx
Superfamily-SCOP PLP-dependent transferases UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6IZ42 ENTREZGENE, UniProtKB/TrEMBL
  A6IZ43_RAT UniProtKB/TrEMBL
  A6IZ44_RAT UniProtKB/TrEMBL
  A6IZ45_RAT UniProtKB/TrEMBL
  ATTY_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5EBB6 ENTREZGENE
  Q9QWS4 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q5EBB6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Tat  tyrosine aminotransferase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function catalyzes the conversion of L-tyrosine into p-hydroxyphenylpyruvate