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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3820
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tat
Name: tyrosine aminotransferase
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tatincreases activityEXP 6480464CTDDexamethasone results in increased activity of TAT proteinPMID:15698539 PMID:16307467 PMID:9259316 PMID:9398635
Tatincreases expressionEXP 6480464CTDDexamethasone results in increased expression of TAT mRNA; Dexamethasone results in increased expression of TAT proteinPMID:16267830 PMID:20599767 PMID:2882798 PMID:2899290 PMID:9398635 PMID:9566755
Tatmultiple interactionsEXP 6480464CTD1,4-dihydropyridine analog inhibits the reaction [Dexamethasone results in increased activity of TAT protein]; Cadmium affects the reaction [Dexamethasone results in increased activity of TAT protein]; Calcimycin promotes the reaction [Dexamethasone results in increased activity of TAT protein]; Dactinomycin inhibits the reaction [Dexamethasone results in increased activity of TAT protein]; Dactinomycin inhibits the reaction [Dexamethasone results in increased expression of TAT mRNA]; Dactinomycin inhibits the reaction [Ursodeoxycholic Acid promotes the reaction [Dexamethasone results in increased activity of TAT protein]]; Dexamethasone promotes the reaction [[NR3C1 protein binds to TAT promoter] which results in increased expression of TAT mRNA]; Mercury inhibits the reaction [Dexamethasone results in increased activity of TAT protein]; Methyldimethylaminoazobenzene inhibits the reaction [Dexamethasone results in increased expression of TAT mRNA]; Mifepristone inhibits the reaction [Dexamethasone results in increased activity of TAT protein]; Mifepristone inhibits the reaction [Dexamethasone results in increased expression of TAT mRNA]; Sphingosine inhibits the reaction [Calcimycin promotes the reaction [Dexamethasone results in increased activity of TAT protein]]; Sphingosine inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [Dexamethasone results in increased activity of TAT protein]]; Sphingosine inhibits the reaction [Ursodeoxycholic Acid promotes the reaction [Dexamethasone results in increased activity of TAT protein]]; Tetradecanoylphorbol Acetate promotes the reaction [Dexamethasone results in increased activity of TAT protein]; Ursodeoxycholic Acid promotes the reaction [Dexamethasone results in increased activity of TAT protein]; Ursodeoxycholic Acid promotes the reaction [Dexamethasone results in increased expression of TAT mRNA]PMID:15698539 PMID:16267830 PMID:16307467 PMID:20599767 PMID:22465009 PMID:8975639 PMID:9398635 PMID:9566755
Tatdecreases expressionISOTAT (Homo sapiens)6480464CTDDexamethasone results in decreased expression of TAT proteinPMID:37467946
Tatincreases activityISOTat (Mus musculus)6480464CTDDexamethasone results in increased activity of TAT proteinPMID:14694204
Tatincreases expressionISOTat (Mus musculus)6480464CTDDexamethasone results in increased expression of TAT mRNAPMID:16267830 PMID:29222744 PMID:35589016
Tatincreases expressionISOTAT (Homo sapiens)6480464CTDDexamethasone results in increased expression of TAT mRNAPMID:19022236 PMID:28483492 PMID:34197882 PMID:35589016
Tatmultiple interactionsISOTat (Mus musculus)6480464CTDMifepristone inhibits the reaction [Dexamethasone results in increased expression of TAT mRNA]; NR3C1 protein affects the reaction [Dexamethasone results in increased expression of TAT mRNA]; NR3C1 protein affects the reaction [Dexamethasone results in increased expression of TAT protein]; o-Aminoazotoluene inhibits the reaction [Dexamethasone results in increased expression of TAT mRNA]PMID:16267830 PMID:29222744 PMID:35589016
Tatmultiple interactionsISOTAT (Homo sapiens)6480464CTDDactinomycin inhibits the reaction [Dexamethasone results in increased expression of TAT mRNA]; Mifepristone inhibits the reaction [Dexamethasone results in increased expression of TAT mRNA]; NR3C1 protein affects the reaction [Dexamethasone results in increased expression of TAT mRNA]; NR3C1 protein affects the reaction [Dexamethasone results in increased expression of TAT protein]PMID:19022236 PMID:28483492 PMID:35589016
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