Eif2s1 (eukaryotic translation initiation factor 2 subunit alpha) - Rat Genome Database

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Gene: Eif2s1 (eukaryotic translation initiation factor 2 subunit alpha) Rattus norvegicus
Symbol: Eif2s1
Name: eukaryotic translation initiation factor 2 subunit alpha
RGD ID: 620963
Description: Predicted to enable ribosome binding activity and translation initiation factor activity. Involved in several processes, including negative regulation of guanyl-nucleotide exchange factor activity; positive regulation of cell death; and response to manganese-induced endoplasmic reticulum stress. Located in cytoplasm; glial limiting end-foot; and nucleus. Part of eukaryotic translation initiation factor 2 complex and translation initiation ternary complex. Used to study middle cerebral artery infarction. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha); PARTICIPATES IN translation initiation pathway; Endoplasmic Reticulum-associated degradation pathway; hepatitis C pathway; INTERACTS WITH (+)-schisandrin B; (R)-lipoic acid; (S)-nicotine.
Type: protein-coding
Previously known as: eIF-2-alpha; EIF-2A; EIF-2alpha; eukaryotic translation initiation factor 2 subunit 1; eukaryotic translation initiation factor 2 subunit 1 alpha; eukaryotic translation initiation factor 2, subunit 1 (alpha ); eukaryotic translation initiation factor 2, subunit 1 alpha; MGC93488
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2697,672,829 - 97,697,499 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl697,672,766 - 97,706,225 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx698,102,349 - 98,127,010 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0698,401,511 - 98,426,172 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0697,788,465 - 97,813,132 (+)NCBIRnor_WKY
Rnor_6.06102,048,372 - 102,073,041 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6102,048,372 - 102,073,041 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06111,422,397 - 111,447,066 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46101,495,444 - 101,520,113 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera696,060,793 - 96,085,462 (+)NCBICelera
Cytogenetic Map6q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(+)-schisandrin B  (EXP)
(R)-lipoic acid  (EXP)
(S)-nicotine  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP)
1,4-dithiothreitol  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4-dichlorophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-arachidonoylglycerol  (ISO)
3-acetyldeoxynivalenol  (ISO)
3-chloropropane-1,2-diol  (EXP,ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (EXP,ISO)
5-fluorouracil  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP)
acrolein  (ISO)
acrylamide  (EXP,ISO)
acrylonitrile  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
agomelatine  (EXP)
AICA ribonucleotide  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
Aloe emodin  (ISO)
alpha-naphthoflavone  (ISO)
amino acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
anandamide  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (ISO)
Aurin  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-carotene  (ISO)
beta-D-glucosamine  (EXP,ISO)
bilirubin IXalpha  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
boric acid  (ISO)
bortezomib  (ISO)
bupropion  (ISO)
busulfan  (ISO)
C.I. Natural Red 20  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
camptothecin  (EXP,ISO)
cantharidin  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carboplatin  (ISO)
chlorogenic acid  (EXP)
chlorpyrifos  (ISO)
cholesterol  (ISO)
chromium(6+)  (ISO)
chrysophanol  (ISO)
cisplatin  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
D-penicillamine  (ISO)
dantrolene  (EXP,ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
diclofenac  (ISO)
dihydrocapsaicin  (ISO)
dihydroxyacetone  (ISO)
Dinitramine  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
ebselen  (EXP)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
epoxomicin  (ISO)
erlotinib hydrochloride  (EXP)
ethanol  (ISO)
flavokawain B  (ISO)
flavonoids  (EXP)
flufenoxuron  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
glafenine  (EXP)
glucose  (EXP,ISO)
glutathione  (ISO)
glyphosate  (EXP)
GSK2656157  (EXP,ISO)
Guanabenz  (EXP,ISO)
hexadecanoic acid  (ISO)
homocysteic acid  (EXP)
homocysteine  (ISO)
Honokiol  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
indoxyl sulfate  (ISO)
ivermectin  (ISO)
ketoconazole  (ISO)
L-1,4-dithiothreitol  (ISO)
L-glutamic acid  (EXP)
lead diacetate  (EXP)
lead(II) chloride  (ISO)
leflunomide  (ISO)
linsidomine  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
losartan  (EXP)
luteolin  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP,ISO)
melatonin  (EXP)
metformin  (EXP)
methamphetamine  (EXP)
methapyrilene  (EXP)
methylmercury chloride  (ISO)
mevastatin  (ISO)
minocycline  (EXP,ISO)
mitoxantrone  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methylnicotinate  (ISO)
naloxone  (ISO)
nefazodone  (EXP)
niclosamide  (ISO)
nicotine  (EXP)
nimesulide  (EXP)
ochratoxin A  (ISO)
okadaic acid  (EXP)
oxycodone  (EXP,ISO)
ozone  (EXP)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
Pendulone  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenethyl isothiocyanate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
potassium atom  (EXP)
proanthocyanidin  (EXP)
pyrazinecarboxamide  (EXP,ISO)
quercetin  (ISO)
quinolinic acid  (EXP)
raloxifene  (ISO)
resveratrol  (ISO)
rifampicin  (EXP)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
salubrinal  (EXP,ISO)
Salvianolic acid A  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
scopolamine  (EXP)
selenomethionine  (EXP)
sertraline  (ISO)
Shikonin  (EXP)
sirolimus  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
Sodium iodate  (ISO)
staurosporine  (ISO)
streptozocin  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
T-2 toxin  (EXP,ISO)
tamoxifen  (ISO)
tauroursodeoxycholic acid  (EXP,ISO)
tenofovir disoproxil fumarate  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP,ISO)
thioacetamide  (EXP)
thiostrepton  (ISO)
titanium dioxide  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP,ISO)
triclocarban  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
trovafloxacin  (EXP)
tunicamycin  (EXP,ISO)
ursolic acid  (ISO)
valproic acid  (ISO)
vildagliptin  (EXP)
zidovudine  (ISO)
zinc oxide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Changes in the phosphorylation of initiation factor eIF-2alpha, elongation factor eEF-2 and p70 S6 kinase after transient focal cerebral ischaemia in mice. Althausen S, etal., J Neurochem. 2001 Aug;78(4):779-87.
2. Shape and location of eukaryotic initiation factor eIF-2 on the 40S ribosomal subunit of rat liver. Immunoelectron-microscopic and hydrodynamic investigations. Bommer UA, etal., Eur J Biochem. 1988 Mar 15;172(3):653-62.
3. Identification of proteins of the 40 S ribosomal subunit involved in interaction with initiation factor eIF-2 in the quaternary initiation complex by means of monospecific antibodies. Bommer UA, etal., FEBS Lett. 1988 Jun 6;233(1):114-8.
4. Phosphorylation of the alpha subunit of initiation factor 2 correlates with the inhibition of translation following transient cerebral ischaemia in the rat. Burda J, etal., Biochem J. 1994 Sep 1;302 ( Pt 2):335-8.
5. Rat fibroblasts transfected with the human 70-kDa heat shock gene exhibit altered translation and eukaryotic initiation factor 2 alpha phosphorylation following heat shock. Chang GC, etal., Int J Hyperthermia. 1994 May-Jun;10(3):325-37.
6. Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis. Cnop M, etal., J Biol Chem. 2007 Feb 9;282(6):3989-97. Epub 2006 Dec 8.
7. Alpha subunit of eukaryotic translational initiation factor-2 is a heat-shock protein. Colbert RA, etal., J Biol Chem. 1987 Dec 15;262(35):16763-6.
8. Effect of brain ischemia and reperfusion on the localization of phosphorylated eukaryotic initiation factor 2 alpha. DeGracia DJ, etal., J Cereb Blood Flow Metab. 1997 Dec;17(12):1291-302.
9. Cloning and sequencing of complementary DNAs encoding the alpha-subunit of translational initiation factor eIF-2. Characterization of the protein and its messenger RNA. Ernst H, etal., J Biol Chem 1987 Jan 25;262(3):1206-12.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
12. Ultrastructural localization of phosphorylated eIF2alpha in rat dorsal hippocampus during reperfusion. Goldstein EN, etal., Acta Neuropathol. 1999 Nov;98(5):493-505.
13. [Role of PERK/eIF2a signaling pathway in hepatocyte apoptosis of alcoholic liver injury rats]. Han XH, etal., Zhonghua Gan Zang Bing Za Zhi. 2010 Oct;18(10):768-72. doi: 10.3760/cma.j.issn.1007-3418.2010.10.011.
14. The mechanism of eukaryotic translation initiation: new insights and challenges. Hinnebusch AG and Lorsch JR, Cold Spring Harb Perspect Biol. 2012 Oct 1;4(10). pii: a011544. doi: 10.1101/cshperspect.a011544.
15. The scanning mechanism of eukaryotic translation initiation. Hinnebusch AG Annu Rev Biochem. 2014;83:779-812. doi: 10.1146/annurev-biochem-060713-035802. Epub 2014 Jan 29.
16. Reduced eIF2alpha phosphorylation and increased proapoptotic proteins in aging. Hussain SG and Ramaiah KV, Biochem Biophys Res Commun. 2007 Apr 6;355(2):365-70. Epub 2007 Feb 6.
17. Assessment of biomarkers of protein anabolism in skeletal muscle during the life span of the rat: sarcopenia despite elevated protein synthesis. Kimball SR, etal., Am J Physiol Endocrinol Metab. 2004 Oct;287(4):E772-80. Epub 2004 Jun 8.
18. Regulation of guanine nucleotide exchange through phosphorylation of eukaryotic initiation factor eIF2alpha. Role of the alpha- and delta-subunits of eiF2b. Kimball SR, etal., J Biol Chem. 1998 May 22;273(21):12841-5.
19. TNF-alpha mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's beta-amyloid oligomers in mice and monkeys. Lourenco MV, etal., Cell Metab. 2013 Dec 3;18(6):831-43. doi: 10.1016/j.cmet.2013.11.002.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
21. Renal ischemia and reperfusion activates the eIF 2 alpha kinase PERK. Montie HL, etal., Biochim Biophys Acta. 2005 Sep 25;1741(3):314-24.
22. Endoplasmic reticulum stress plays critical role in brain damage after cerebral ischemia/reperfusion in rats. Nakka VP, etal., Neurotox Res. 2010 Feb;17(2):189-202. doi: 10.1007/s12640-009-9110-5.
23. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
24. Activated mTOR and PKR kinases in lymphocytes correlate with memory and cognitive decline in Alzheimer's disease. Paccalin M, etal., Dement Geriatr Cogn Disord. 2006;22(4):320-6. Epub 2006 Sep 4.
25. Upregulation of iNOS expression and phosphorylation of eIF-2alpha are paralleled by suppression of protein synthesis in rat hypothalamus in a closed head trauma model. Petrov T, etal., J Neurotrauma. 2001 Aug;18(8):799-812.
26. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
27. GOA pipeline RGD automated data pipeline
28. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Endoplasmic reticulum stress inhibition protects against excitotoxic neuronal injury in the rat brain. Sokka AL, etal., J Neurosci. 2007 Jan 24;27(4):901-8.
31. Endoplasmic reticulum stress features are prominent in Alzheimer disease but not in prion diseases in vivo. Unterberger U, etal., J Neuropathol Exp Neurol. 2006 Apr;65(4):348-57.
32. Regulation of eukaryotic initiation factor-2 expression during sepsis. Vary TC, etal., Am J Physiol. 1994 Feb;266(2 Pt 1):E193-201.
33. Pinocembrin protects brain against ischemia/reperfusion injury by attenuating endoplasmic reticulum stress induced apoptosis. Wu CX, etal., Neurosci Lett. 2013 Jun 24;546:57-62. doi: 10.1016/j.neulet.2013.04.060. Epub 2013 May 10.
34. alpha-Synuclein is involved in manganese-induced ER stress via PERK signal pathway in organotypic brain slice cultures. Xu B, etal., Mol Neurobiol. 2014 Feb;49(1):399-412. doi: 10.1007/s12035-013-8527-2. Epub 2013 Aug 10.
Additional References at PubMed
PMID:10882126   PMID:11106749   PMID:11323413   PMID:12176355   PMID:12388085   PMID:12477932   PMID:15489334   PMID:15937339   PMID:16176978   PMID:16289705   PMID:16452087   PMID:16854843  
PMID:17894550   PMID:18508033   PMID:19139267   PMID:19861488   PMID:19946888   PMID:20458337   PMID:22082260   PMID:22658674   PMID:22681889   PMID:22883908   PMID:23063529   PMID:23376485  
PMID:24006279   PMID:25057203   PMID:26120832   PMID:27338925   PMID:27430620   PMID:29289717   PMID:30053369   PMID:33450132   PMID:36438488  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2697,672,829 - 97,697,499 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl697,672,766 - 97,706,225 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx698,102,349 - 98,127,010 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0698,401,511 - 98,426,172 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0697,788,465 - 97,813,132 (+)NCBIRnor_WKY
Rnor_6.06102,048,372 - 102,073,041 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6102,048,372 - 102,073,041 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06111,422,397 - 111,447,066 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46101,495,444 - 101,520,113 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera696,060,793 - 96,085,462 (+)NCBICelera
Cytogenetic Map6q24NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381467,360,328 - 67,386,516 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1467,360,328 - 67,386,516 (+)EnsemblGRCh38hg38GRCh38
GRCh371467,827,045 - 67,853,233 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361466,896,787 - 66,922,986 (+)NCBINCBI36Build 36hg18NCBI36
Build 341466,896,837 - 66,921,909NCBI
Celera1447,886,088 - 47,912,287 (+)NCBICelera
Cytogenetic Map14q23.3NCBI
HuRef1447,996,958 - 48,023,152 (+)NCBIHuRef
CHM1_11467,765,718 - 67,791,923 (+)NCBICHM1_1
T2T-CHM13v2.01461,567,453 - 61,593,639 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391278,908,846 - 78,933,784 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1278,908,593 - 78,933,784 (+)EnsemblGRCm39 Ensembl
GRCm381278,862,072 - 78,887,010 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1278,861,819 - 78,887,010 (+)EnsemblGRCm38mm10GRCm38
MGSCv371279,963,059 - 79,987,997 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361279,780,910 - 79,804,371 (+)NCBIMGSCv36mm8
Celera1280,326,532 - 80,351,470 (+)NCBICelera
Cytogenetic Map12C3NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554662,838,785 - 2,855,172 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554662,838,785 - 2,855,443 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.11466,813,953 - 66,839,866 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1466,813,953 - 66,839,866 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01447,935,691 - 47,960,055 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1841,354,400 - 41,371,676 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl841,351,244 - 41,371,056 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha841,045,920 - 41,062,790 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0841,581,554 - 41,598,447 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl841,581,926 - 41,600,736 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1841,200,418 - 41,217,284 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0841,273,999 - 41,290,966 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0841,632,932 - 41,649,922 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440864063,422,172 - 63,445,032 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649510,745,923 - 10,773,199 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493649510,746,687 - 10,769,304 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl791,085,335 - 91,109,827 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1791,085,025 - 91,109,835 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2797,394,525 - 97,417,715 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12444,599,017 - 44,623,723 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2444,598,287 - 44,623,298 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605332,828,857 - 32,856,268 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462473433,621,782 - 33,640,549 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473433,624,246 - 33,640,667 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Eif2s1
119 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:236
Count of miRNA genes:150
Interacting mature miRNAs:169
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)645790088104200226Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)657730540104085867Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)657730540104085867Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)658632962103632962Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)661747639106747639Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
1641904Alcrsp4Alcohol response QTL 4response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)667262953112262953Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)671201409116201409Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)672202632115200186Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)672202632117202632Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)673463459109394713Rat
2293837Kiddil1Kidney dilation QTL 13.7kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)681132889104393926Rat
2293842Kiddil3Kidney dilation QTL 34.3kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)681132889104393926Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)682523650110548006Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)683190345106747639Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
1300076Glom8Glomerulus QTL 870.000000009kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)689762877106752806Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2697,697,117 - 97,697,300 (+)MAPPERmRatBN7.2
Rnor_6.06102,072,660 - 102,072,842NCBIRnor6.0
Rnor_5.06111,446,685 - 111,446,867UniSTSRnor5.0
RGSC_v3.46101,519,732 - 101,519,914UniSTSRGSC3.4
Celera696,085,081 - 96,085,263UniSTS
Cytogenetic Map6q24UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2697,697,583 - 97,697,760 (+)MAPPERmRatBN7.2
Rnor_6.06102,073,126 - 102,073,302NCBIRnor6.0
Rnor_5.06111,447,151 - 111,447,327UniSTSRnor5.0
RGSC_v3.46101,520,198 - 101,520,374UniSTSRGSC3.4
Celera696,085,547 - 96,085,723UniSTS
RH 3.4 Map6689.9UniSTS
Cytogenetic Map6q24UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21925,412,659 - 25,412,966 (-)MAPPERmRatBN7.2
mRatBN7.21654,401,102 - 54,401,395 (+)MAPPERmRatBN7.2
Rnor_6.01657,881,477 - 57,881,769NCBIRnor6.0
Rnor_6.01923,844,155 - 23,844,461NCBIRnor6.0
Rnor_5.01934,828,004 - 34,828,310UniSTSRnor5.0
Rnor_5.01657,565,260 - 57,565,552UniSTSRnor5.0
RGSC_v3.41658,041,512 - 58,041,804UniSTSRGSC3.4
RGSC_v3.41927,151,277 - 27,151,583UniSTSRGSC3.4
Celera1924,947,364 - 24,947,670UniSTS
Celera1652,484,247 - 52,484,539UniSTS
Cytogenetic Map19q11UniSTS
Cytogenetic Map6q24UniSTS
Cytogenetic Map16q12.1UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Below cutoff


Reference Sequences
RefSeq Acc Id: ENSRNOT00000013375   ⟹   ENSRNOP00000013375
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl697,672,766 - 97,706,225 (+)Ensembl
Rnor_6.0 Ensembl6102,048,372 - 102,073,041 (+)Ensembl
RefSeq Acc Id: NM_019356   ⟹   NP_062229
Rat AssemblyChrPosition (strand)Source
mRatBN7.2697,672,829 - 97,697,499 (+)NCBI
Rnor_6.06102,048,372 - 102,073,041 (+)NCBI
Rnor_5.06111,422,397 - 111,447,066 (+)NCBI
RGSC_v3.46101,495,444 - 101,520,113 (+)RGD
Celera696,060,793 - 96,085,462 (+)RGD
Protein Sequences
Protein RefSeqs NP_062229 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41110 (Get FASTA)   NCBI Sequence Viewer  
  AAH87019 (Get FASTA)   NCBI Sequence Viewer  
  EDM03706 (Get FASTA)   NCBI Sequence Viewer  
  EDM03707 (Get FASTA)   NCBI Sequence Viewer  
  P68101 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_062229   ⟸   NM_019356
- UniProtKB: P05199 (UniProtKB/Swiss-Prot),   P68101 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000013375   ⟸   ENSRNOT00000013375
Protein Domains
S1 motif

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P68101-F1-model_v2 AlphaFold P68101 1-315 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13694688
Promoter ID:EPDNEW_R5213
Type:initiation region
Description:eukaryotic translation initiation factor 2 subunit alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.06102,048,273 - 102,048,333EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620963 AgrOrtholog
BioCyc Gene G2FUF-36986 BioCyc
Ensembl Genes ENSRNOG00000009432 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000013375 ENTREZGENE
  ENSRNOP00000013375.2 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000013375 ENTREZGENE
  ENSRNOT00000013375.5 UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot UniProtKB/Swiss-Prot
InterPro NA-bd_OB-fold UniProtKB/Swiss-Prot
  S1_dom UniProtKB/Swiss-Prot
  S1_domain UniProtKB/Swiss-Prot
  S1_IF2_alpha UniProtKB/Swiss-Prot
  TIF2_asu_C UniProtKB/Swiss-Prot
  TIF2_asu_middle_sf UniProtKB/Swiss-Prot
  TIF_2_asu UniProtKB/Swiss-Prot
KEGG Report rno:54318 UniProtKB/Swiss-Prot
  PTHR10602 UniProtKB/Swiss-Prot
Pfam EIF_2_alpha UniProtKB/Swiss-Prot
  PF00575 UniProtKB/Swiss-Prot
PhenoGen Eif2s1 PhenoGen
PROSITE PS50126 UniProtKB/Swiss-Prot
SMART SM00316 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF110993 UniProtKB/Swiss-Prot
  SSF116742 UniProtKB/Swiss-Prot
  SSF50249 UniProtKB/Swiss-Prot
UniProt IF2A_RAT UniProtKB/Swiss-Prot
UniProt Secondary P05199 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-07 Eif2s1  eukaryotic translation initiation factor 2 subunit alpha  Eif2s1  eukaryotic translation initiation factor 2 subunit 1 alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-26 Eif2s1  eukaryotic translation initiation factor 2 subunit 1 alpha  Eif2s1  eukaryotic translation initiation factor 2 subunit 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-25 Eif2s1  eukaryotic translation initiation factor 2 subunit 1  Eif2s1  eukaryotic translation initiation factor 2, subunit 1 alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Eif2s1  eukaryotic translation initiation factor 2, subunit 1 alpha    eukaryotic translation initiation factor 2, subunit 1 (alpha )  Name updated 1299863 APPROVED
2002-08-07 Eif2s1  eukaryotic translation initiation factor 2, subunit 1 (alpha )      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_protein 315 amino acids; 36.1 kDa 728211