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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620963
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Eif2s1
Name: eukaryotic translation initiation factor 2 subunit alpha
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Eif2s1decreases phosphorylationISOEif2s1 (Mus musculus)6480464CTDAcetaminophen results in decreased phosphorylation of EIF2S1 proteinPMID:31524377
Eif2s1increases phosphorylationISOEif2s1 (Mus musculus)6480464CTDAcetaminophen results in increased phosphorylation of EIF2S1 proteinPMID:19931551
Eif2s1multiple interactionsISOEif2s1 (Mus musculus)6480464CTDGuanabenz inhibits the reaction [Acetaminophen results in decreased phosphorylation of EIF2S1 protein]PMID:31524377
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