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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620963
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Eif2s1
Name: eukaryotic translation initiation factor 2 subunit alpha
Acc ID: CHEBI:73755
Term: 1,2-dimethylhydrazine
Definition: A member of the class of hydrazines that is hydrazine in which one of the hydrogens attached to each nitrogen is replaced by a methyl group. A powerful DNA alkylating agent and carcinogen, it is used to induce colon cancer in laboratory rats and mice.
Chemical ID: MESH:D019813
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Eif2s1decreases phosphorylationEXP 6480464CTD1,2-Dimethylhydrazine results in decreased phosphorylation of EIF2S1 proteinPMID:29879413
Eif2s1multiple interactionsEXP 6480464CTD[1,2-Dimethylhydrazine co-treated with p-coumaric acid] results in decreased expression of EIF2S1 protein; p-coumaric acid inhibits the reaction [1,2-Dimethylhydrazine results in decreased phosphorylation of EIF2S1 protein]PMID:29879413
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