EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha) - Rat Genome Database

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Gene: EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha) Chlorocebus sabaeus
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Symbol: EIF2S1
Name: eukaryotic translation initiation factor 2 subunit alpha
RGD ID: 18538690
Description: ENCODES a protein that exhibits ribosome binding (inferred); RNA binding (inferred); translation initiation factor activity (inferred); INVOLVED IN cellular response to heat (ortholog); negative regulation of guanyl-nucleotide exchange factor activity (ortholog); positive regulation of type B pancreatic cell apoptotic process (ortholog); PARTICIPATES IN translation initiation pathway; ASSOCIATED WITH Alcoholic Liver Diseases (ortholog); Alzheimer's disease (ortholog); Brain Hypoxia-Ischemia (ortholog); FOUND IN eukaryotic translation initiation factor 2 complex (ortholog); glial limiting end-foot (ortholog); mitochondrion (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: eukaryotic translation initiation factor 2 subunit 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12444,599,017 - 44,623,723 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2444,598,287 - 44,623,298 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605332,828,857 - 32,856,268 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
EIF2S1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12444,599,017 - 44,623,723 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2444,598,287 - 44,623,298 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605332,828,857 - 32,856,268 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
EIF2S1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381467,360,328 - 67,386,516 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1467,360,328 - 67,386,516 (+)EnsemblGRCh38hg38GRCh38
GRCh371467,827,045 - 67,853,233 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361466,896,787 - 66,922,986 (+)NCBINCBI36Build 36hg18NCBI36
Build 341466,896,837 - 66,921,909NCBI
Celera1447,886,088 - 47,912,287 (+)NCBICelera
Cytogenetic Map14q23.3NCBI
HuRef1447,996,958 - 48,023,152 (+)NCBIHuRef
CHM1_11467,765,718 - 67,791,923 (+)NCBICHM1_1
T2T-CHM13v2.01461,567,453 - 61,593,639 (+)NCBIT2T-CHM13v2.0
Eif2s1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391278,908,846 - 78,933,784 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1278,908,593 - 78,933,784 (+)EnsemblGRCm39 Ensembl
GRCm381278,862,072 - 78,887,010 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1278,861,819 - 78,887,010 (+)EnsemblGRCm38mm10GRCm38
MGSCv371279,963,059 - 79,987,997 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361279,780,910 - 79,804,371 (+)NCBIMGSCv36mm8
Celera1280,326,532 - 80,351,470 (+)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1235.51NCBI
Eif2s1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86103,405,880 - 103,430,549 (+)NCBIGRCr8
mRatBN7.2697,672,829 - 97,697,499 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl697,672,766 - 97,706,225 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx698,102,349 - 98,127,010 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0698,401,511 - 98,426,172 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0697,788,465 - 97,813,132 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06102,048,372 - 102,073,041 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6102,048,372 - 102,073,041 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06111,422,397 - 111,447,066 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46101,495,444 - 101,520,113 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera696,060,793 - 96,085,462 (+)NCBICelera
Cytogenetic Map6q24NCBI
Eif2s1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554662,838,785 - 2,855,172 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554662,838,785 - 2,855,443 (-)NCBIChiLan1.0ChiLan1.0
EIF2S1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21568,465,765 - 68,489,430 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11467,682,677 - 67,708,545 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01447,935,691 - 47,960,055 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11466,813,953 - 66,839,866 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1466,813,953 - 66,839,866 (+)Ensemblpanpan1.1panPan2
EIF2S1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1841,354,400 - 41,371,676 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl841,351,244 - 41,371,056 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha841,045,920 - 41,062,790 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0841,581,554 - 41,598,447 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl841,581,926 - 41,600,736 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1841,200,418 - 41,217,284 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0841,273,999 - 41,290,966 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0841,632,932 - 41,649,922 (+)NCBIUU_Cfam_GSD_1.0
Eif2s1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864063,422,172 - 63,445,032 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649510,745,923 - 10,773,199 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649510,746,687 - 10,769,304 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EIF2S1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl791,085,335 - 91,109,827 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1791,085,025 - 91,109,835 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2797,394,525 - 97,417,715 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Eif2s1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473433,621,782 - 33,640,549 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473433,624,246 - 33,640,667 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000011418   ⟹   ENSCSAP00000009490
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2444,598,287 - 44,623,298 (+)Ensembl
RefSeq Acc Id: XM_007987056   ⟹   XP_007985247
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12444,599,017 - 44,623,723 (+)NCBI
Vero_WHO_p1.0NW_02366605332,828,857 - 32,856,268 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007987057   ⟹   XP_007985248
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12444,599,181 - 44,623,723 (+)NCBI
Vero_WHO_p1.0NW_02366605332,829,124 - 32,856,268 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007985247 (Get FASTA)   NCBI Sequence Viewer  
  XP_007985248 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000009490
  ENSCSAP00000009490.1
RefSeq Acc Id: XP_007985247   ⟸   XM_007987056
- UniProtKB: A0A0D9RLK1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007985248   ⟸   XM_007987057
- UniProtKB: A0A0D9RLK1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000009490   ⟸   ENSCSAT00000011418


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000013324 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000011418.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.140 UniProtKB/TrEMBL
  3.30.70.1130 UniProtKB/TrEMBL
InterPro NA-bd_OB-fold UniProtKB/TrEMBL
  S1_domain UniProtKB/TrEMBL
  S1_IF2_alpha UniProtKB/TrEMBL
  TIF2_asu_C UniProtKB/TrEMBL
  TIF2_asu_middle_sf UniProtKB/TrEMBL
  TIF_2_asu UniProtKB/TrEMBL
KEGG Report csab:103229205 UniProtKB/TrEMBL
NCBI Gene EIF2S1 ENTREZGENE
PANTHER EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1 UniProtKB/TrEMBL
  PTHR10602 UniProtKB/TrEMBL
Pfam EIF_2_alpha UniProtKB/TrEMBL
  PF00575 UniProtKB/TrEMBL
PROSITE PS50126 UniProtKB/TrEMBL
SMART SM00316 UniProtKB/TrEMBL
Superfamily-SCOP SSF110993 UniProtKB/TrEMBL
  SSF116742 UniProtKB/TrEMBL
  SSF50249 UniProtKB/TrEMBL
UniProt A0A0D9RLK1 ENTREZGENE, UniProtKB/TrEMBL