RGD Reference Report - Activated mTOR and PKR kinases in lymphocytes correlate with memory and cognitive decline in Alzheimer's disease. - Rat Genome Database

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Activated mTOR and PKR kinases in lymphocytes correlate with memory and cognitive decline in Alzheimer's disease.

Authors: Paccalin, M  Pain-Barc, S  Pluchon, C  Paul, C  Besson, MN  Carret-Rebillat, AS  Rioux-Bilan, A  Gil, R  Hugon, J 
Citation: Paccalin M, etal., Dement Geriatr Cogn Disord. 2006;22(4):320-6. Epub 2006 Sep 4.
RGD ID: 10395343
Pubmed: PMID:16954686   (View Abstract at PubMed)
DOI: DOI:10.1159/000095562   (Journal Full-text)

BACKGROUND: The control of translation, involving the kinases mTOR (mammalian target of rapamycin) and PKR (double-stranded RNA-dependent protein kinase), modulates cell survival and death and is altered in the brains of patients with Alzheimer's disease (AD). In AD increased susceptibility of lymphocytes to apoptosis has been reported. METHODS: We investigated the level of the kinases mTOR and PKR and the eukaryotic initiation factor 2alpha (eIF2alpha) in lymphocytes of patients with AD in comparison with controls. In AD patients we also looked for a correlation between activated proteins and cognitive and memory tests. RESULTS: We report significant alterations of the levels of these kinases and eIF2alpha in lymphocytes of AD patients that were also significantly correlated with cognitive and memory test scores. CONCLUSION: These results suggest that the levels of mTOR, PKR and eIF2alpha in lymphocytes could follow the cognitive decline in AD.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Alzheimer's disease severityIEP 10395343 RGD 
Alzheimer's disease severityISOEIF2S1 (Homo sapiens)10395343; 10395343 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Eif2s1  (eukaryotic translation initiation factor 2 subunit alpha)

Genes (Mus musculus)
Eif2s1  (eukaryotic translation initiation factor 2, subunit 1 alpha)

Genes (Homo sapiens)
EIF2S1  (eukaryotic translation initiation factor 2 subunit alpha)


Additional Information