Eif2s1 (eukaryotic translation initiation factor 2, subunit 1 alpha) - Rat Genome Database

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Gene: Eif2s1 (eukaryotic translation initiation factor 2, subunit 1 alpha) Mus musculus
Analyze
Symbol: Eif2s1
Name: eukaryotic translation initiation factor 2, subunit 1 alpha
RGD ID: 731513
MGI Page MGI
Description: Predicted to enable ribosome binding activity and translation initiation factor activity. Involved in several processes, including cellular response to amino acid starvation; negative regulation of translational initiation in response to stress; and stress granule assembly. Acts upstream of or within protein autophosphorylation; regulation of translational initiation in response to stress; and translation. Located in cytoplasmic stress granule and nucleus. Is active in synapse. Is expressed in several structures, including brain ventricular layer; jaw; nose; orbito-sphenoid; and thymus primordium. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 0910001O23Rik; 2410026C18Rik; 35kDa; Eif; eIF-2-alpha; eIF-2A; eIF-2alpha; eIF2; eIF2-alpha; Eif2a; eIF2alpha; eukaryotic translation initiation factor 2 subunit 1; eukaryotic translation initiation factor 2 subunit alpha; eukaryotic translation initiation factor 2A
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Gm12734   Gm13915   Gm7459  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391278,908,846 - 78,933,784 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1278,908,593 - 78,933,784 (+)EnsemblGRCm39 Ensembl
GRCm381278,862,072 - 78,887,010 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1278,861,819 - 78,887,010 (+)EnsemblGRCm38mm10GRCm38
MGSCv371279,963,059 - 79,987,997 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361279,780,910 - 79,804,371 (+)NCBIMGSCv36mm8
Celera1280,326,532 - 80,351,470 (+)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1235.51NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(+)-schisandrin B  (ISO)
(R)-lipoic acid  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1,4-dithiothreitol  (EXP,ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4-dichlorophenol  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-arachidonoylglycerol  (ISO)
3-acetyldeoxynivalenol  (EXP)
3-chloropropane-1,2-diol  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (EXP,ISO)
5-fluorouracil  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-Methoxyflavone  (ISO)
6-propyl-2-thiouracil  (ISO)
acrolein  (EXP,ISO)
acrylamide  (ISO)
acrylonitrile  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
agomelatine  (ISO)
AICA ribonucleotide  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
Alisol B  (ISO)
all-trans-retinoic acid  (EXP,ISO)
Aloe emodin  (ISO)
alpha-naphthoflavone  (EXP)
aluminium sulfate (anhydrous)  (EXP)
amino acid  (EXP)
amiodarone  (EXP,ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
anandamide  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
atorvastatin calcium  (ISO)
Aurin  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (EXP)
benzo[a]pyrene diol epoxide I  (EXP,ISO)
beta-carotene  (EXP)
beta-D-glucosamine  (EXP,ISO)
beta-lapachone  (ISO)
bilirubin IXalpha  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
boric acid  (EXP,ISO)
bortezomib  (EXP,ISO)
bupropion  (ISO)
busulfan  (EXP)
C.I. Natural Red 20  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
camptothecin  (ISO)
cantharidin  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
carboplatin  (ISO)
chlorogenic acid  (ISO)
chlorpyrifos  (ISO)
cholesterol  (EXP)
chromium(6+)  (EXP)
chrysophanol  (ISO)
cisplatin  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cordycepin  (EXP)
coumestrol  (ISO)
cycloheximide  (EXP,ISO)
cyclosporin A  (EXP)
cyfluthrin  (ISO)
D-glucose  (EXP,ISO)
D-penicillamine  (ISO)
dantrolene  (ISO)
dexamethasone  (EXP)
diarsenic trioxide  (EXP,ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (ISO)
diclofenac  (ISO)
dihydrocapsaicin  (ISO)
dihydroxyacetone  (ISO)
Dinitramine  (EXP)
dioxygen  (EXP)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ebselen  (ISO)
endosulfan  (ISO)
enzyme inhibitor  (EXP)
epoxomicin  (EXP)
erastin  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (ISO)
flavokawain B  (ISO)
flavonoids  (ISO)
flufenoxuron  (EXP)
flutamide  (ISO)
folic acid  (EXP)
fructose  (EXP)
fulvestrant  (ISO)
gentamycin  (ISO)
geraniol  (ISO)
glafenine  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glyphosate  (ISO)
GSK2656157  (EXP,ISO)
Guanabenz  (EXP,ISO)
hexadecanoic acid  (EXP)
homocysteic acid  (ISO)
homocysteine  (ISO)
Honokiol  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
indoxyl sulfate  (EXP)
ivermectin  (ISO)
kainic acid  (ISO)
ketoconazole  (EXP)
L-1,4-dithiothreitol  (EXP,ISO)
L-glutamic acid  (ISO)
lead diacetate  (ISO)
lead(II) chloride  (ISO)
leflunomide  (ISO)
Leonurine  (ISO)
linsidomine  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
losartan  (ISO)
luteolin  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melatonin  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methimazole  (ISO)
methylmercury chloride  (EXP)
mevastatin  (EXP)
minocycline  (EXP,ISO)
mitoxantrone  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methylnicotinate  (EXP)
naloxone  (ISO)
nefazodone  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
nimesulide  (ISO)
NORCANTHARIDIN  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oxycodone  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP)
paraquat  (EXP,ISO)
Pendulone  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenethyl isothiocyanate  (EXP,ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
poly(I:C)  (ISO)
potassium atom  (ISO)
proanthocyanidin  (ISO)
procymidone  (EXP)
propiconazole  (ISO)
pyrazinecarboxamide  (ISO)
quercetin  (ISO)
quinolinic acid  (ISO)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
ricolinostat  (ISO)
rifampicin  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
salubrinal  (EXP,ISO)
Salvianolic acid A  (EXP)
SB 203580  (EXP)
SB 431542  (ISO)
scopolamine  (ISO)
selenomethionine  (ISO)
sertraline  (ISO)
Shikonin  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
Sodium iodate  (ISO)
staurosporine  (EXP)
streptozocin  (EXP)
succimer  (EXP)
sulfadimethoxine  (ISO)
sulforaphane  (EXP,ISO)
T-2 toxin  (EXP,ISO)
tamoxifen  (EXP)
tauroursodeoxycholic acid  (ISO)
tenofovir disoproxil fumarate  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP,ISO)
thioacetamide  (ISO)
thiostrepton  (ISO)
titanium dioxide  (EXP)
toosendanin  (EXP,ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP,ISO)
triclocarban  (ISO)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
troglitazone  (ISO)
trovafloxacin  (ISO)
tunicamycin  (EXP,ISO)
ursolic acid  (ISO)
valproic acid  (EXP,ISO)
vanillic acid  (ISO)
vildagliptin  (ISO)
zidovudine  (ISO)
zinc oxide  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Changes in the phosphorylation of initiation factor eIF-2alpha, elongation factor eEF-2 and p70 S6 kinase after transient focal cerebral ischaemia in mice. Althausen S, etal., J Neurochem. 2001 Aug;78(4):779-87.
2. Phosphorylation of the alpha subunit of initiation factor 2 correlates with the inhibition of translation following transient cerebral ischaemia in the rat. Burda J, etal., Biochem J. 1994 Sep 1;302 ( Pt 2):335-8.
3. Ultrastructural localization of phosphorylated eIF2alpha in rat dorsal hippocampus during reperfusion. Goldstein EN, etal., Acta Neuropathol. 1999 Nov;98(5):493-505.
4. [Role of PERK/eIF2a signaling pathway in hepatocyte apoptosis of alcoholic liver injury rats]. Han XH, etal., Zhonghua Gan Zang Bing Za Zhi. 2010 Oct;18(10):768-72. doi: 10.3760/cma.j.issn.1007-3418.2010.10.011.
5. The mechanism of eukaryotic translation initiation: new insights and challenges. Hinnebusch AG and Lorsch JR, Cold Spring Harb Perspect Biol. 2012 Oct 1;4(10). pii: a011544. doi: 10.1101/cshperspect.a011544.
6. The scanning mechanism of eukaryotic translation initiation. Hinnebusch AG Annu Rev Biochem. 2014;83:779-812. doi: 10.1146/annurev-biochem-060713-035802. Epub 2014 Jan 29.
7. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
8. Assessment of biomarkers of protein anabolism in skeletal muscle during the life span of the rat: sarcopenia despite elevated protein synthesis. Kimball SR, etal., Am J Physiol Endocrinol Metab. 2004 Oct;287(4):E772-80. Epub 2004 Jun 8.
9. TNF-alpha mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's beta-amyloid oligomers in mice and monkeys. Lourenco MV, etal., Cell Metab. 2013 Dec 3;18(6):831-43. doi: 10.1016/j.cmet.2013.11.002.
10. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
11. MGDs mouse GO annotations MGD data from the GO Consortium
12. MGD IEA MGD IEA
13. Renal ischemia and reperfusion activates the eIF 2 alpha kinase PERK. Montie HL, etal., Biochim Biophys Acta. 2005 Sep 25;1741(3):314-24.
14. Endoplasmic reticulum stress plays critical role in brain damage after cerebral ischemia/reperfusion in rats. Nakka VP, etal., Neurotox Res. 2010 Feb;17(2):189-202. doi: 10.1007/s12640-009-9110-5.
15. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
16. Activated mTOR and PKR kinases in lymphocytes correlate with memory and cognitive decline in Alzheimer's disease. Paccalin M, etal., Dement Geriatr Cogn Disord. 2006;22(4):320-6. Epub 2006 Sep 4.
17. Upregulation of iNOS expression and phosphorylation of eIF-2alpha are paralleled by suppression of protein synthesis in rat hypothalamus in a closed head trauma model. Petrov T, etal., J Neurotrauma. 2001 Aug;18(8):799-812.
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. Mouse MP Annotation Import Pipeline RGD automated import pipeline
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Endoplasmic reticulum stress inhibition protects against excitotoxic neuronal injury in the rat brain. Sokka AL, etal., J Neurosci. 2007 Jan 24;27(4):901-8.
23. Endoplasmic reticulum stress features are prominent in Alzheimer disease but not in prion diseases in vivo. Unterberger U, etal., J Neuropathol Exp Neurol. 2006 Apr;65(4):348-57.
24. Regulation of eukaryotic initiation factor-2 expression during sepsis. Vary TC, etal., Am J Physiol. 1994 Feb;266(2 Pt 1):E193-201.
25. Pinocembrin protects brain against ischemia/reperfusion injury by attenuating endoplasmic reticulum stress induced apoptosis. Wu CX, etal., Neurosci Lett. 2013 Jun 24;546:57-62. doi: 10.1016/j.neulet.2013.04.060. Epub 2013 May 10.
Additional References at PubMed
PMID:2808516   PMID:8889548   PMID:9746750   PMID:10349636   PMID:10882104   PMID:10882126   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11106749   PMID:11430820   PMID:12176355  
PMID:12388085   PMID:12477932   PMID:12520002   PMID:12897138   PMID:12904583   PMID:14610273   PMID:14638860   PMID:15475356   PMID:15489334   PMID:15542827   PMID:15544353   PMID:15684420  
PMID:15684421   PMID:15705563   PMID:15735755   PMID:15774759   PMID:15788409   PMID:15930128   PMID:15937339   PMID:15980866   PMID:16000157   PMID:16141072   PMID:16141073   PMID:16176978  
PMID:16377306   PMID:16439558   PMID:16452087   PMID:16492139   PMID:16794605   PMID:16835242   PMID:17090218   PMID:17170114   PMID:17274640   PMID:17309103   PMID:17325203   PMID:17418795  
PMID:17596516   PMID:18052927   PMID:18362164   PMID:18378896   PMID:18604219   PMID:18776938   PMID:18799693   PMID:19017641   PMID:19139267   PMID:19181853   PMID:19470760   PMID:19583950  
PMID:19754954   PMID:19759130   PMID:19846675   PMID:19861488   PMID:20029030   PMID:20034494   PMID:20072654   PMID:20559319   PMID:20886088   PMID:21076179   PMID:21223507   PMID:21267068  
PMID:21565905   PMID:21677750   PMID:21873635   PMID:21880833   PMID:22009178   PMID:22153080   PMID:22509299   PMID:22833567   PMID:22883908   PMID:23000413   PMID:23022383   PMID:23314846  
PMID:23354132   PMID:23665500   PMID:23933749   PMID:24457600   PMID:24594939   PMID:24648524   PMID:24726366   PMID:24889041   PMID:24974795   PMID:25211037   PMID:25332179   PMID:25537833  
PMID:25590801   PMID:25695629   PMID:25883808   PMID:26031337   PMID:26167872   PMID:26173459   PMID:26400930   PMID:26414443   PMID:26816051   PMID:26928076   PMID:26928234   PMID:26982722  
PMID:27225776   PMID:27416896   PMID:27430620   PMID:27613409   PMID:27698114   PMID:27746211   PMID:27960077   PMID:28320871   PMID:28378742   PMID:28478109   PMID:28726788   PMID:28781602  
PMID:29289717   PMID:29295856   PMID:29518331   PMID:29530978   PMID:30201312   PMID:30417358   PMID:30595499   PMID:30635284   PMID:31138784   PMID:31522764   PMID:31554636   PMID:31727829  
PMID:31801950   PMID:31836389   PMID:31894919   PMID:31905741   PMID:32150794   PMID:32325033   PMID:32566674   PMID:32707059   PMID:32937139   PMID:32973043   PMID:33029011   PMID:33318147  
PMID:33361822   PMID:33879538   PMID:33879865   PMID:33888613   PMID:34133714   PMID:34643429   PMID:35434801   PMID:36114006   PMID:36126165   PMID:36343752   PMID:36539111   PMID:36660474  
PMID:36841836   PMID:36996814   PMID:37031820   PMID:37142655   PMID:38159280   PMID:38187761   PMID:38355793  


Genomics

Comparative Map Data
Eif2s1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391278,908,846 - 78,933,784 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1278,908,593 - 78,933,784 (+)EnsemblGRCm39 Ensembl
GRCm381278,862,072 - 78,887,010 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1278,861,819 - 78,887,010 (+)EnsemblGRCm38mm10GRCm38
MGSCv371279,963,059 - 79,987,997 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361279,780,910 - 79,804,371 (+)NCBIMGSCv36mm8
Celera1280,326,532 - 80,351,470 (+)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1235.51NCBI
EIF2S1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381467,360,328 - 67,386,516 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1467,360,328 - 67,386,516 (+)EnsemblGRCh38hg38GRCh38
GRCh371467,827,045 - 67,853,233 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361466,896,787 - 66,922,986 (+)NCBINCBI36Build 36hg18NCBI36
Build 341466,896,837 - 66,921,909NCBI
Celera1447,886,088 - 47,912,287 (+)NCBICelera
Cytogenetic Map14q23.3NCBI
HuRef1447,996,958 - 48,023,152 (+)NCBIHuRef
CHM1_11467,765,718 - 67,791,923 (+)NCBICHM1_1
T2T-CHM13v2.01461,567,453 - 61,593,639 (+)NCBIT2T-CHM13v2.0
Eif2s1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86103,405,880 - 103,430,549 (+)NCBIGRCr8
mRatBN7.2697,672,829 - 97,697,499 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl697,672,766 - 97,706,225 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx698,102,349 - 98,127,010 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0698,401,511 - 98,426,172 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0697,788,465 - 97,813,132 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06102,048,372 - 102,073,041 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6102,048,372 - 102,073,041 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06111,422,397 - 111,447,066 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46101,495,444 - 101,520,113 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera696,060,793 - 96,085,462 (+)NCBICelera
Cytogenetic Map6q24NCBI
Eif2s1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554662,838,785 - 2,855,172 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554662,838,785 - 2,855,443 (-)NCBIChiLan1.0ChiLan1.0
EIF2S1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21568,465,765 - 68,489,430 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11467,682,677 - 67,708,545 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01447,935,691 - 47,960,055 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11466,813,953 - 66,839,866 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1466,813,953 - 66,839,866 (+)Ensemblpanpan1.1panPan2
EIF2S1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1841,354,400 - 41,371,676 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl841,351,244 - 41,371,056 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha841,045,920 - 41,062,790 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0841,581,554 - 41,598,447 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl841,581,926 - 41,600,736 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1841,200,418 - 41,217,284 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0841,273,999 - 41,290,966 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0841,632,932 - 41,649,922 (+)NCBIUU_Cfam_GSD_1.0
Eif2s1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864063,422,172 - 63,445,032 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649510,745,923 - 10,773,199 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649510,746,687 - 10,769,304 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EIF2S1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl791,085,335 - 91,109,827 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1791,085,025 - 91,109,835 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2797,394,525 - 97,417,715 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EIF2S1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12444,599,017 - 44,623,723 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2444,598,287 - 44,623,298 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605332,828,857 - 32,856,268 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eif2s1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473433,621,782 - 33,640,549 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473433,624,246 - 33,640,667 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Eif2s1
915 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:590
Count of miRNA genes:366
Interacting mature miRNAs:457
Transcripts:ENSMUST00000071230
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
14746976Manh73_mmandible shape 73 (mouse)126585713199857131Mouse
27226776Tibl6_mtibia length 6, 5 week (mouse)126064678692666774Mouse
1301337Cdcs8_mcytokine deficiency colitis susceptibility 8 (mouse)Not determined126468908398689229Mouse
1300633Cdcs7_mcytokine deficiency colitis susceptibility 7 (mouse)Not determined126468908398689229Mouse
27226771Tibl14_mtibia length 14, 10 week (mouse)126834677498766259Mouse
4142002Tbqt3_mtibia bone quality traits 3 (mouse)Not determined1235285496109936243Mouse
12832727Ahrq1_mairway hyperresponsiveness QTL 1 (mouse)125469591082665939Mouse
1558978Cplaq10_mcircadian period of locomotor activity 10 (mouse)Not determined121534102679040364Mouse
1301574Lmblgq5_mlimb length QTL 5 (mouse)Not determined121759644780956883Mouse
4141738Tgq23_mtriglyceride QTL 23 (mouse)Not determined72112877106112877Mouse
13207568Tcq14_mtotal cholesterol QTL 14 (mouse)121166000197176774Mouse
27226753Femd7_mfemur midshaft diameter 7, 10 week (mouse)12955000084146774Mouse
1357749Vtbt13_mvertebral trabecular bone trait 13 (mouse)Not determined125313200287132145Mouse
13524842Ppiq10a_mprepulse inhibition QTL 10a (mouse)1277512220111512220Mouse
1301046Par3_mpulmonary adenoma resistance 3 (mouse)Not determined126395670897956883Mouse
1357757Lnopy2_mlens opacity 2 (mouse)Not determined125284662686846796Mouse
1301689Skull18_mskull morphology 18 (mouse)Not determined1273887422107887526Mouse
10043895Bw20_mbody weight QTL 20 (mouse)Not determined126230825296308252Mouse
27226797Scvln19_msacral vertebrae length 2, 16 week (mouse)126214678699466259Mouse
1357479Splwt1_mspleen weight 1 (mouse)Not determined124169317590887526Mouse
10043948Pbft6_mpercent body fat 6 (mouse)Not determined126120542795205427Mouse
1301926Adip6_madiposity 6 (mouse)Not determined1273887422107887526Mouse
27226793Feml10_mfemur length 10, 5 week (mouse)1268346774113363620Mouse
27226728Tibl20_mtibia length 20, 16 week (mouse)125914678693866774Mouse
1301476Pbwg12_mpostnatal body weight growth 12 (mouse)Not determined126204016496040364Mouse

Markers in Region
Eif2a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12D1UniSTS
cM Map12 UniSTS
cM MapUN UniSTS
cM Map15 UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000071230   ⟹   ENSMUSP00000071214
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1278,908,593 - 78,933,784 (+)Ensembl
GRCm38.p6 Ensembl1278,861,819 - 78,887,010 (+)Ensembl
Ensembl Acc Id: ENSMUST00000219754
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1278,908,859 - 78,910,500 (+)Ensembl
GRCm38.p6 Ensembl1278,862,085 - 78,863,726 (+)Ensembl
Ensembl Acc Id: ENSMUST00000220382
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1278,908,904 - 78,927,948 (+)Ensembl
GRCm38.p6 Ensembl1278,862,130 - 78,881,174 (+)Ensembl
RefSeq Acc Id: NM_026114   ⟹   NP_080390
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391278,908,846 - 78,933,784 (+)NCBI
GRCm381278,862,072 - 78,887,010 (+)ENTREZGENE
MGSCv371279,963,059 - 79,987,997 (+)RGD
Celera1280,326,532 - 80,351,470 (+)RGD
cM Map12 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_080390   ⟸   NM_026114
- UniProtKB: Q6ZWX6 (UniProtKB/Swiss-Prot),   Q3TIQ0 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000071214   ⟸   ENSMUST00000071230
Protein Domains
S1 motif

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6ZWX6-F1-model_v2 AlphaFold Q6ZWX6 1-315 view protein structure

Promoters
RGD ID:8678622
Promoter ID:EPDNEW_M17341
Type:initiation region
Name:Eif2s1_1
Description:Mus musculus eukaryotic translation initiation factor 2, subunit1 alpha , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381278,862,070 - 78,862,130EPDNEW
RGD ID:6822750
Promoter ID:MM_KWN:12022
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_023721,   OTTMUST00000077865
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361279,961,986 - 79,963,157 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:95299 AgrOrtholog
Ensembl Genes ENSMUSG00000021116 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000071230 ENTREZGENE
  ENSMUST00000071230.8 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.50.140 UniProtKB/Swiss-Prot
  3.30.70.1130 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro NA-bd_OB-fold UniProtKB/Swiss-Prot
  S1_domain UniProtKB/Swiss-Prot
  S1_IF2_alpha UniProtKB/Swiss-Prot
  TIF2_asu_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIF2_asu_middle_sf UniProtKB/Swiss-Prot
  TIF_2_asu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:13665 UniProtKB/Swiss-Prot
MGD MGI:95299 ENTREZGENE
NCBI Gene Eif2s1 ENTREZGENE
PANTHER EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10602 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EIF_2_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00575 UniProtKB/Swiss-Prot
PhenoGen Eif2s1 PhenoGen
PROSITE PS50126 UniProtKB/Swiss-Prot
SMART SM00316 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF110993 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF116742 UniProtKB/Swiss-Prot
  SSF50249 UniProtKB/Swiss-Prot
UniProt IF2A_MOUSE UniProtKB/Swiss-Prot
  Q3TIQ0 ENTREZGENE
  Q6ZWX6 ENTREZGENE
  Q9CV24_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q3TIQ0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-08-26 Eif2s1  eukaryotic translation initiation factor 2, subunit 1 alpha  2410026C18Rik  RIKEN cDNA 2410026C18 gene  Symbol and/or name updated 27372883 PROVISIONAL
2024-08-21 2410026C18Rik  RIKEN cDNA 2410026C18 gene  Eif2s1  eukaryotic translation initiation factor 2, subunit 1 alpha  Symbol and/or name change 5135510 APPROVED