Eif2s1 (eukaryotic translation initiation factor 2, subunit 1 alpha) - Rat Genome Database

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Gene: Eif2s1 (eukaryotic translation initiation factor 2, subunit 1 alpha) Mus musculus
Analyze
Symbol: Eif2s1
Name: eukaryotic translation initiation factor 2, subunit 1 alpha
RGD ID: 731513
MGI Page MGI
Description: Enables translation initiation factor activity. Involved in several processes, including cellular response to amino acid starvation; negative regulation of translational initiation in response to stress; and stress granule assembly. Acts upstream of or within protein autophosphorylation; regulation of translational initiation in response to stress; and translation. Located in cytoplasmic stress granule and nucleus. Is active in synapse. Is expressed in several structures, including brain ventricular layer; jaw; nose; orbito-sphenoid; and thymus primordium. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 0910001O23Rik; 2410026C18Rik; 35kDa; Eif; eIF-2-alpha; eIF-2A; eIF-2alpha; eIF2; eIF2-alpha; Eif2a; eIF2alpha; eukaryotic translation initiation factor 2 subunit 1; eukaryotic translation initiation factor 2 subunit alpha; eukaryotic translation initiation factor 2A
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Gm12734   Gm13915   Gm7459  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391278,908,846 - 78,933,784 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1278,908,593 - 78,933,784 (+)EnsemblGRCm39 Ensembl
GRCm381278,862,072 - 78,887,010 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1278,861,819 - 78,887,010 (+)EnsemblGRCm38mm10GRCm38
MGSCv371279,963,059 - 79,987,997 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361279,780,910 - 79,804,371 (+)NCBIMGSCv36mm8
Celera1280,326,532 - 80,351,470 (+)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1235.51NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Eif2s1MouseLeber congenital amaurosis 13  ISOEIF2S1 (Homo sapiens)8554872ClinVar Annotator: match by term: Leber congenital amaurosis 13ClinVarPMID:28492532
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Original Reference(s)
Eif2s1MouseAlzheimer's disease  ISOEIF2S1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17406652
Eif2s1Mousecognitive disorder  ISOEIF2S1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17406652
Eif2s1MouseNerve Degeneration  ISOEIF2S1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16492139
Eif2s1Mouseosteosarcoma  ISOEIF2S1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:14767549
Eif2s1Mousestatus epilepticus  ISOEIF2S1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15003282

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Original Reference(s)
Eif2s1Mouse(+)-pilocarpine multiple interactionsEXP 6480464Pilocarpine promotes the reaction [EIF2AK2 protein modified form results in increased phosphorylation of EIF2S1 protein] more ...CTDPMID:16492139
Eif2s1Mouse(+)-pilocarpine increases phosphorylationEXP 6480464Pilocarpine results in increased phosphorylation of EIF2S1 proteinCTDPMID:15003282
Eif2s1Mouse(+)-schisandrin B multiple interactionsISOEif2s1 (Rattus norvegicus)6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of EIF2S1 mRNA]CTDPMID:31150632
Eif2s1Mouse(R)-lipoic acid multiple interactionsISOEif2s1 (Rattus norvegicus)6480464Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of EIF2S1 protein modified form]CTDPMID:30605698
Eif2s1Mouse(S)-nicotine increases phosphorylationISOEif2s1 (Rattus norvegicus)6480464Nicotine results in increased phosphorylation of EIF2S1 proteinCTDPMID:26803847
Eif2s1Mouse1,2-dichloroethane decreases expressionEXP 6480464ethylene dichloride results in decreased expression of EIF2S1 mRNACTDPMID:28189721 and PMID:28960355
Eif2s1Mouse1,2-dimethylhydrazine decreases phosphorylationISOEif2s1 (Rattus norvegicus)64804641 and 2-Dimethylhydrazine results in decreased phosphorylation of EIF2S1 proteinCTDPMID:29879413
Eif2s1Mouse1,2-dimethylhydrazine multiple interactionsISOEif2s1 (Rattus norvegicus)6480464[1 more ...CTDPMID:29879413
Eif2s1Mouse1,4-dithiothreitol multiple interactionsEXP 6480464EIF2S1 protein mutant form inhibits the reaction [Dithiothreitol results in increased phosphorylation of EIF2S1 protein]CTDPMID:30385349
Eif2s1Mouse1,4-dithiothreitol increases phosphorylationISOEIF2S1 (Homo sapiens)6480464Dithiothreitol results in increased phosphorylation of EIF2S1 proteinCTDPMID:34244458
Eif2s1Mouse1,4-dithiothreitol increases phosphorylationEXP 6480464Dithiothreitol results in increased phosphorylation of EIF2S1 proteinCTDPMID:30385349
Eif2s1Mouse17alpha-ethynylestradiol affects expressionEXP 6480464Ethinyl Estradiol affects the expression of EIF2S1 mRNACTDPMID:17555576
Eif2s1Mouse17alpha-ethynylestradiol multiple interactionsEXP 6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EIF2S1 mRNACTDPMID:17942748
Eif2s1Mouse17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of EIF2S1 mRNACTDPMID:17942748
Eif2s1Mouse17beta-estradiol increases expressionISOEIF2S1 (Homo sapiens)6480464Estradiol results in increased expression of EIF2S1 mRNACTDPMID:16514628 and PMID:31614463
Eif2s1Mouse17beta-estradiol affects expressionISOEif2s1 (Rattus norvegicus)6480464Estradiol affects the expression of EIF2S1 proteinCTDPMID:32145629
Eif2s1Mouse17beta-estradiol multiple interactionsISOEIF2S1 (Homo sapiens)6480464Estradiol promotes the reaction [EIF2S1 protein binds to ESR1 protein]CTDPMID:27156127
Eif2s1Mouse17beta-estradiol affects expressionEXP 6480464Estradiol affects the expression of EIF2S1 mRNACTDPMID:15598610
Eif2s1Mouse2,2',4,4'-Tetrabromodiphenyl ether multiple interactionsEXP 6480464epoxomicin inhibits the reaction [troxerutin inhibits the reaction [2 more ...CTDPMID:25639565
Eif2s1Mouse2,2',4,4'-Tetrabromodiphenyl ether affects expressionEXP 64804642 more ...CTDPMID:30294300

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Biological Process
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Original Reference(s)
Eif2s1Mousecellular response to amino acid starvation involved_inIDA 2290270 PMID:11106749UniProtPMID:11106749
Eif2s1Mousecellular response to heat involved_inIEAUniProtKB:P68101 and ensembl:ENSRNOP000000133752290270 EnsemblGO_REF:0000107
Eif2s1Mousecellular response to heat involved_inISOEif2s1 (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Eif2s1Mousecellular response to heat  ISOEif2s1 (Rattus norvegicus)9068941 RGDPMID:3500171 more ...
Eif2s1Mousecellular response to oxidative stress involved_inIMP 2290270 PMID:27430620ARUK-UCLPMID:27430620
Eif2s1Mousecellular response to UV involved_inIDA 2290270 PMID:12176355UniProtPMID:12176355
Eif2s1MouseHRI-mediated signaling involved_inISSUniProtKB:P051982290270 UniProtGO_REF:0000024
Eif2s1MouseHRI-mediated signaling involved_inISOUniProtKB:P051982290270 GO_CentralGO_REF:0000119
Eif2s1Mousemitophagy involved_inISSUniProtKB:P051982290270 UniProtGO_REF:0000024
Eif2s1Mousemitophagy involved_inISOUniProtKB:P051982290270 GO_CentralGO_REF:0000119
Eif2s1Mousenegative regulation of guanyl-nucleotide exchange factor activity  ISOEif2s1 (Rattus norvegicus)9068941 RGDPMID:9582312 and REF_RGD_ID:1581075
Eif2s1Mousenegative regulation of translational initiation in response to stress involved_inIDA 2290270 PMID:12176355UniProtPMID:12176355
Eif2s1MousePERK-mediated unfolded protein response involved_inISSUniProtKB:P051982290270 UniProtGO_REF:0000024
Eif2s1MousePERK-mediated unfolded protein response involved_inISOUniProtKB:P051982290270 GO_CentralGO_REF:0000119
Eif2s1Mousepositive regulation of type B pancreatic cell apoptotic process involved_inISOEif2s1 (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Eif2s1Mousepositive regulation of type B pancreatic cell apoptotic process involved_inIEAUniProtKB:P68101 and ensembl:ENSRNOP000000133752290270 EnsemblGO_REF:0000107
Eif2s1Mousepositive regulation of type B pancreatic cell apoptotic process  ISOEif2s1 (Rattus norvegicus)9068941 RGDPMID:17158450 and REF_RGD_ID:10395350
Eif2s1Mouseprotein autophosphorylation acts_upstream_of_or_withinIDA 2290270 PMID:19139267MGIPMID:19139267
Eif2s1Mouseregulation of translation in response to endoplasmic reticulum stress involved_inISOUniProtKB:P051982290270 GO_CentralGO_REF:0000119
Eif2s1Mouseregulation of translation in response to endoplasmic reticulum stress involved_inIEAUniProtKB:P05198 and ensembl:ENSP000002563832290270 EnsemblGO_REF:0000107
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Cellular Component
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Original Reference(s)
Eif2s1Mousecytoplasm located_inIDA 2290270 PMID:12388085MGIPMID:12388085
Eif2s1Mousecytoplasmic stress granule located_inIDA 2290270 PMID:19861488UniProtPMID:19861488
Eif2s1Mousecytosol located_inISOUniProtKB:P051982290270 GO_CentralGO_REF:0000119
Eif2s1Mousecytosol located_inTAS 2290270 ReactomeReactome:R-MMU-9655565
Eif2s1Mouseeukaryotic 48S preinitiation complex part_ofIBAPANTHER:PTN000063908 and SGD:S0000037672290270 GO_CentralGO_REF:0000033
Eif2s1Mouseeukaryotic translation initiation factor 2 complex part_ofISSUniProtKB:P051982290270 PMID:31836389UniProtPMID:31836389
Eif2s1Mouseeukaryotic translation initiation factor 2 complex part_ofISOUniProtKB:P051982290270 GO_CentralGO_REF:0000119
Eif2s1Mouseeukaryotic translation initiation factor 2 complex part_ofISSUniProtKB:P204592290270 UniProtGO_REF:0000024
Eif2s1Mouseeukaryotic translation initiation factor 2 complex part_ofISOEif2s1 (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Eif2s1Mouseeukaryotic translation initiation factor 2 complex part_ofIBAPANTHER:PTN000063908 more ...2290270 GO_CentralGO_REF:0000033
Eif2s1Mouseeukaryotic translation initiation factor 2 complex  ISOEif2s1 (Rattus norvegicus)9068941 RGDPMID:2450747 and REF_RGD_ID:10395356
Eif2s1Mouseglial limiting end-foot  ISOEif2s1 (Rattus norvegicus)9068941 RGDPMID:9397028 and REF_RGD_ID:10395349
Eif2s1Mouseglial limiting end-foot located_inISOEif2s1 (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Eif2s1Mouseglial limiting end-foot located_inIEAUniProtKB:P68101 and ensembl:ENSRNOP000000133752290270 EnsemblGO_REF:0000107
Eif2s1Mousemitochondrion is_active_inISOUniProtKB:P051982290270 GO_CentralGO_REF:0000119
Eif2s1Mousemitochondrion is_active_inISSUniProtKB:P051982290270 UniProtGO_REF:0000024
Eif2s1Mousenucleus located_inIDA 2290270 PMID:12388085MGIPMID:12388085
Eif2s1Mousesynapse is_active_inIDA 2290270 PMID:16452087 and PMID:25211037SynGOPMID:16452087 and PMID:25211037
Eif2s1Mousesynapse is_active_inEXP 2290270 PMID:16452087 and PMID:25211037SynGOPMID:16452087 and PMID:25211037
Eif2s1Mousetranslation initiation ternary complex part_ofIEAUniProtKB:P68101 and ensembl:ENSRNOP000000133752290270 EnsemblGO_REF:0000107
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Molecular Function
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RGD Manual Annotations


  
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Original Reference(s)
Eif2s1Mousetranslation initiation pathway  ISOEIF2S1 (Homo sapiens)10002776 RGD 
Eif2s1Mousetranslation initiation pathway  ISOEIF2S1 (Homo sapiens)10044017 RGD 

Imported Annotations - KEGG (archival)

Object Symbol
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Original Reference(s)
Eif2s1MouseEndoplasmic Reticulum-associated degradation pathway  IEA 6907045 KEGGmmu:04141
Eif2s1Mousehepatitis C pathway  IEA 6907045 KEGGmmu:05160
Eif2s1Mouseinfluenza A pathway  IEA 6907045 KEGGmmu:05164
Eif2s1Mousemeasles pathway  IEA 6907045 KEGGmmu:05162

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#
Reference Title
Reference Citation
1. Changes in the phosphorylation of initiation factor eIF-2alpha, elongation factor eEF-2 and p70 S6 kinase after transient focal cerebral ischaemia in mice. Althausen S, etal., J Neurochem. 2001 Aug;78(4):779-87.
2. Phosphorylation of the alpha subunit of initiation factor 2 correlates with the inhibition of translation following transient cerebral ischaemia in the rat. Burda J, etal., Biochem J. 1994 Sep 1;302 ( Pt 2):335-8.
3. Ultrastructural localization of phosphorylated eIF2alpha in rat dorsal hippocampus during reperfusion. Goldstein EN, etal., Acta Neuropathol. 1999 Nov;98(5):493-505.
4. [Role of PERK/eIF2a signaling pathway in hepatocyte apoptosis of alcoholic liver injury rats]. Han XH, etal., Zhonghua Gan Zang Bing Za Zhi. 2010 Oct;18(10):768-72. doi: 10.3760/cma.j.issn.1007-3418.2010.10.011.
5. The mechanism of eukaryotic translation initiation: new insights and challenges. Hinnebusch AG and Lorsch JR, Cold Spring Harb Perspect Biol. 2012 Oct 1;4(10). pii: a011544. doi: 10.1101/cshperspect.a011544.
6. The scanning mechanism of eukaryotic translation initiation. Hinnebusch AG Annu Rev Biochem. 2014;83:779-812. doi: 10.1146/annurev-biochem-060713-035802. Epub 2014 Jan 29.
7. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
8. Assessment of biomarkers of protein anabolism in skeletal muscle during the life span of the rat: sarcopenia despite elevated protein synthesis. Kimball SR, etal., Am J Physiol Endocrinol Metab. 2004 Oct;287(4):E772-80. Epub 2004 Jun 8.
9. TNF-alpha mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's beta-amyloid oligomers in mice and monkeys. Lourenco MV, etal., Cell Metab. 2013 Dec 3;18(6):831-43. doi: 10.1016/j.cmet.2013.11.002.
10. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
11. MGDs mouse GO annotations MGD data from the GO Consortium
12. MGD IEA MGD IEA
13. Renal ischemia and reperfusion activates the eIF 2 alpha kinase PERK. Montie HL, etal., Biochim Biophys Acta. 2005 Sep 25;1741(3):314-24.
14. Endoplasmic reticulum stress plays critical role in brain damage after cerebral ischemia/reperfusion in rats. Nakka VP, etal., Neurotox Res. 2010 Feb;17(2):189-202. doi: 10.1007/s12640-009-9110-5.
15. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
16. Activated mTOR and PKR kinases in lymphocytes correlate with memory and cognitive decline in Alzheimer's disease. Paccalin M, etal., Dement Geriatr Cogn Disord. 2006;22(4):320-6. Epub 2006 Sep 4.
17. Upregulation of iNOS expression and phosphorylation of eIF-2alpha are paralleled by suppression of protein synthesis in rat hypothalamus in a closed head trauma model. Petrov T, etal., J Neurotrauma. 2001 Aug;18(8):799-812.
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. Mouse MP Annotation Import Pipeline RGD automated import pipeline
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
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PMID:2808516   PMID:8889548   PMID:9746750   PMID:9930704   PMID:10349636   PMID:10882104   PMID:10882126   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11106749   PMID:11430820  
PMID:12176355   PMID:12388085   PMID:12477932   PMID:12520002   PMID:12897138   PMID:12904583   PMID:14610273   PMID:14638860   PMID:14676213   PMID:15475356   PMID:15489334   PMID:15542827  
PMID:15544353   PMID:15684420   PMID:15684421   PMID:15705563   PMID:15735755   PMID:15774759   PMID:15788409   PMID:15930128   PMID:15937339   PMID:15980866   PMID:16000157   PMID:16141072  
PMID:16141073   PMID:16176978   PMID:16377306   PMID:16439558   PMID:16452087   PMID:16492139   PMID:16794605   PMID:16835242   PMID:17090218   PMID:17170114   PMID:17274640   PMID:17309103  
PMID:17325203   PMID:17418795   PMID:17596516   PMID:18052927   PMID:18362164   PMID:18378896   PMID:18604219   PMID:18776938   PMID:18799693   PMID:19017641   PMID:19139267   PMID:19181853  
PMID:19470760   PMID:19583950   PMID:19754954   PMID:19759130   PMID:19846675   PMID:19861488   PMID:20029030   PMID:20034494   PMID:20072654   PMID:20559319   PMID:20886088   PMID:21076179  
PMID:21223507   PMID:21267068   PMID:21565905   PMID:21677750   PMID:21873635   PMID:21880833   PMID:22009178   PMID:22153080   PMID:22509299   PMID:22833567   PMID:22883908   PMID:23000413  
PMID:23022383   PMID:23314846   PMID:23354132   PMID:23665500   PMID:23933749   PMID:24457600   PMID:24594939   PMID:24648524   PMID:24726366   PMID:24889041   PMID:24974795   PMID:25211037  
PMID:25332179   PMID:25537833   PMID:25590801   PMID:25695629   PMID:25883808   PMID:26031337   PMID:26167872   PMID:26173459   PMID:26400930   PMID:26414443   PMID:26816051   PMID:26928076  
PMID:26928234   PMID:26982722   PMID:27225776   PMID:27416896   PMID:27430620   PMID:27613409   PMID:27698114   PMID:27746211   PMID:27960077   PMID:28320871   PMID:28378742   PMID:28478109  
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Eif2s1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391278,908,846 - 78,933,784 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1278,908,593 - 78,933,784 (+)EnsemblGRCm39 Ensembl
GRCm381278,862,072 - 78,887,010 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1278,861,819 - 78,887,010 (+)EnsemblGRCm38mm10GRCm38
MGSCv371279,963,059 - 79,987,997 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361279,780,910 - 79,804,371 (+)NCBIMGSCv36mm8
Celera1280,326,532 - 80,351,470 (+)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1235.51NCBI
EIF2S1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381467,360,328 - 67,386,516 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1467,360,328 - 67,386,516 (+)EnsemblGRCh38hg38GRCh38
GRCh371467,827,045 - 67,853,233 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361466,896,787 - 66,922,986 (+)NCBINCBI36Build 36hg18NCBI36
Build 341466,896,837 - 66,921,909NCBI
Celera1447,886,088 - 47,912,287 (+)NCBICelera
Cytogenetic Map14q23.3NCBI
HuRef1447,996,958 - 48,023,152 (+)NCBIHuRef
CHM1_11467,765,718 - 67,791,923 (+)NCBICHM1_1
T2T-CHM13v2.01461,567,453 - 61,593,639 (+)NCBIT2T-CHM13v2.0
Eif2s1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86103,405,880 - 103,430,549 (+)NCBIGRCr8
mRatBN7.2697,672,829 - 97,697,499 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl697,672,766 - 97,706,225 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx698,102,349 - 98,127,010 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0698,401,511 - 98,426,172 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0697,788,465 - 97,813,132 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06102,048,372 - 102,073,041 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6102,048,372 - 102,073,041 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06111,422,397 - 111,447,066 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46101,495,444 - 101,520,113 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera696,060,793 - 96,085,462 (+)NCBICelera
Cytogenetic Map6q24NCBI
Eif2s1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554662,838,785 - 2,855,172 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554662,838,785 - 2,855,443 (-)NCBIChiLan1.0ChiLan1.0
EIF2S1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21568,465,765 - 68,489,430 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11467,682,677 - 67,708,545 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01447,935,691 - 47,960,055 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11466,813,953 - 66,839,866 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1466,813,953 - 66,839,866 (+)Ensemblpanpan1.1panPan2
EIF2S1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1841,354,400 - 41,371,676 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl841,351,244 - 41,371,056 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha841,045,920 - 41,062,790 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0841,581,554 - 41,598,447 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl841,581,926 - 41,600,736 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1841,200,418 - 41,217,284 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0841,273,999 - 41,290,966 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0841,632,932 - 41,649,922 (+)NCBIUU_Cfam_GSD_1.0
Eif2s1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864063,422,172 - 63,445,032 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649510,745,923 - 10,773,199 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649510,746,687 - 10,769,304 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EIF2S1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl791,085,335 - 91,109,827 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1791,085,025 - 91,109,835 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2797,394,525 - 97,417,715 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EIF2S1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12444,599,017 - 44,623,723 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2444,598,287 - 44,623,298 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605332,828,857 - 32,856,268 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eif2s1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473433,621,782 - 33,640,549 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473433,624,246 - 33,640,667 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Eif2s1
915 total Variants

Predicted Target Of
Summary Value
Count of predictions:590
Count of miRNA genes:366
Interacting mature miRNAs:457
Transcripts:ENSMUST00000071230
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 25 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
14746976Manh73_mmandible shape 73 (mouse)126585713199857131Mouse
27226776Tibl6_mtibia length 6, 5 week (mouse)126064678692666774Mouse
1301337Cdcs8_mcytokine deficiency colitis susceptibility 8 (mouse)Not determined126468908398689229Mouse
1300633Cdcs7_mcytokine deficiency colitis susceptibility 7 (mouse)Not determined126468908398689229Mouse
27226771Tibl14_mtibia length 14, 10 week (mouse)126834677498766259Mouse
4142002Tbqt3_mtibia bone quality traits 3 (mouse)Not determined1235285496109936243Mouse
12832727Ahrq1_mairway hyperresponsiveness QTL 1 (mouse)125469591082665939Mouse
1558978Cplaq10_mcircadian period of locomotor activity 10 (mouse)Not determined121534102679040364Mouse
1301574Lmblgq5_mlimb length QTL 5 (mouse)Not determined121759644780956883Mouse
4141738Tgq23_mtriglyceride QTL 23 (mouse)Not determined72112877106112877Mouse

1 to 10 of 25 rows
Eif2a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12D1UniSTS
cM Map12 UniSTS
cM MapUN UniSTS
cM Map15 UniSTS







Ensembl Acc Id: ENSMUST00000071230   ⟹   ENSMUSP00000071214
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1278,908,593 - 78,933,784 (+)Ensembl
GRCm38.p6 Ensembl1278,861,819 - 78,887,010 (+)Ensembl
Ensembl Acc Id: ENSMUST00000219754
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1278,908,859 - 78,910,500 (+)Ensembl
GRCm38.p6 Ensembl1278,862,085 - 78,863,726 (+)Ensembl
Ensembl Acc Id: ENSMUST00000220382
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1278,908,904 - 78,927,948 (+)Ensembl
GRCm38.p6 Ensembl1278,862,130 - 78,881,174 (+)Ensembl
RefSeq Acc Id: NM_026114   ⟹   NP_080390
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391278,908,846 - 78,933,784 (+)NCBI
GRCm381278,862,072 - 78,887,010 (+)ENTREZGENE
MGSCv371279,963,059 - 79,987,997 (+)RGD
Celera1280,326,532 - 80,351,470 (+)RGD
cM Map12 ENTREZGENE
Sequence:
1 to 12 of 12 rows
Protein RefSeqs NP_080390 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH05463 (Get FASTA)   NCBI Sequence Viewer  
  AAH16448 (Get FASTA)   NCBI Sequence Viewer  
  AAH16497 (Get FASTA)   NCBI Sequence Viewer  
  BAB26593 (Get FASTA)   NCBI Sequence Viewer  
  BAB27049 (Get FASTA)   NCBI Sequence Viewer  
  BAE25400 (Get FASTA)   NCBI Sequence Viewer  
  BAE39796 (Get FASTA)   NCBI Sequence Viewer  
  EDL02629 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000071214
  ENSMUSP00000071214.8
GenBank Protein Q6ZWX6 (Get FASTA)   NCBI Sequence Viewer  
1 to 12 of 12 rows
RefSeq Acc Id: NP_080390   ⟸   NM_026114
- UniProtKB: Q6ZWX6 (UniProtKB/Swiss-Prot),   Q3TIQ0 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000071214   ⟸   ENSMUST00000071230
S1 motif

Name Modeler Protein Id AA Range Protein Structure
AF-Q6ZWX6-F1-model_v2 AlphaFold Q6ZWX6 1-315 view protein structure

RGD ID:8678622
Promoter ID:EPDNEW_M17341
Type:initiation region
Name:Eif2s1_1
Description:Mus musculus eukaryotic translation initiation factor 2, subunit1 alpha , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381278,862,070 - 78,862,130EPDNEW
RGD ID:6822750
Promoter ID:MM_KWN:12022
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_023721,   OTTMUST00000077865
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361279,961,986 - 79,963,157 (-)MPROMDB


1 to 30 of 30 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000021116 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000071230 ENTREZGENE
  ENSMUST00000071230.8 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.50.140 UniProtKB/Swiss-Prot
  3.30.70.1130 UniProtKB/Swiss-Prot
  Translation initiation factor 2, subunit 1, domain 2 UniProtKB/Swiss-Prot
InterPro NA-bd_OB-fold UniProtKB/Swiss-Prot
  S1_domain UniProtKB/Swiss-Prot
  S1_IF2_alpha UniProtKB/Swiss-Prot
  TIF2_asu_C UniProtKB/Swiss-Prot
  TIF2_asu_middle_sf UniProtKB/Swiss-Prot
  TIF_2_asu UniProtKB/Swiss-Prot
KEGG Report mmu:13665 UniProtKB/Swiss-Prot
MGD MGI:95299 ENTREZGENE
NCBI Gene Eif2s1 ENTREZGENE
PANTHER EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1 UniProtKB/Swiss-Prot
  PTHR10602 UniProtKB/Swiss-Prot
Pfam EIF_2_alpha UniProtKB/Swiss-Prot
  PF00575 UniProtKB/Swiss-Prot
PhenoGen Eif2s1 PhenoGen
PROSITE PS50126 UniProtKB/Swiss-Prot
SMART SM00316 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF110993 UniProtKB/Swiss-Prot
  SSF116742 UniProtKB/Swiss-Prot
  SSF50249 UniProtKB/Swiss-Prot
UniProt IF2A_MOUSE UniProtKB/Swiss-Prot
  Q3TIQ0 ENTREZGENE
  Q6ZWX6 ENTREZGENE
  Q9CV24_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q3TIQ0 UniProtKB/Swiss-Prot
1 to 30 of 30 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-08-26 Eif2s1  eukaryotic translation initiation factor 2, subunit 1 alpha  2410026C18Rik  RIKEN cDNA 2410026C18 gene  Symbol and/or name updated 27372883 PROVISIONAL
2024-08-21 2410026C18Rik  RIKEN cDNA 2410026C18 gene  Eif2s1  eukaryotic translation initiation factor 2, subunit 1 alpha  Symbol and/or name change 5135510 APPROVED