Eif2s1 (eukaryotic translation initiation factor 2, subunit 1 alpha) - Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Eif2s1 (eukaryotic translation initiation factor 2, subunit 1 alpha) Mus musculus
Analyze
Symbol: Eif2s1
Name: eukaryotic translation initiation factor 2, subunit 1 alpha
RGD ID: 731513
MGI Page MGI
Description: Predicted to have ribosome binding activity and translation initiation factor activity. Involved in several processes, including cellular protein metabolic process; negative regulation of translational initiation in response to stress; and stress granule assembly. Localizes to cytoplasmic stress granule; nucleus; and synapse. Is expressed in several structures, including brain ventricular layer; jaw; nose; orbito-sphenoid; and thymus primordium. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha); PARTICIPATES IN translation initiation pathway; Endoplasmic Reticulum-associated degradation pathway; hepatitis C pathway; INTERACTS WITH (+)-pilocarpine; 1,2-dichloroethane; 1,4-dithiothreitol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 0910001O23Rik; 2410026C18Rik; 35kDa; Eif; eIF-2-alpha; eIF-2A; eIF-2alpha; eIF2; Eif2a; eIF2alpha; eukaryotic translation initiation factor 2 subunit 1; eukaryotic translation initiation factor 2 subunit alpha; eukaryotic translation initiation factor 2A
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm12734   Gm13915   Gm7459  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391278,908,846 - 78,933,784 (+)NCBIGRCm39mm39
GRCm381278,862,072 - 78,887,010 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1278,861,819 - 78,887,010 (+)EnsemblGRCm38mm10GRCm38
MGSCv371279,963,059 - 79,987,997 (+)NCBIGRCm37mm9NCBIm37
MGSCv361279,780,910 - 79,804,371 (+)NCBImm8
Celera1280,326,532 - 80,351,470 (+)NCBICelera
Cytogenetic Map12C3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(+)-schisandrin B  (ISO)
(R)-lipoic acid  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1,4-dithiothreitol  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4-dichlorophenol  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-arachidonoylglycerol  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (EXP)
4-amino-2,6-dinitrotoluene  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (EXP,ISO)
5-fluorouracil  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
AICA ribonucleotide  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
Aloe emodin  (ISO)
alpha-naphthoflavone  (EXP)
amino acid  (EXP)
amiodarone  (ISO)
ammonium chloride  (ISO)
anandamide  (EXP)
aristolochic acid  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
atorvastatin calcium  (ISO)
Aurin  (ISO)
benzo[a]pyrene  (EXP)
benzo[a]pyrene diol epoxide I  (EXP,ISO)
beta-carotene  (EXP)
beta-D-glucosamine  (EXP,ISO)
bilirubin IXalpha  (ISO)
bisphenol A  (ISO)
boric acid  (EXP,ISO)
bortezomib  (EXP,ISO)
bupropion  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
camptothecin  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
carboplatin  (ISO)
chlorpyrifos  (ISO)
cholesterol  (EXP)
chromium(6+)  (EXP)
chrysophanol  (ISO)
cisplatin  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
cycloheximide  (EXP,ISO)
cyclosporin A  (EXP)
D-glucose  (EXP,ISO)
D-penicillamine  (ISO)
dantrolene  (ISO)
diarsenic trioxide  (EXP,ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (ISO)
diclofenac  (ISO)
dihydrocapsaicin  (ISO)
dioxygen  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ebselen  (ISO)
endosulfan  (ISO)
enzyme inhibitor  (EXP)
epoxomicin  (EXP)
erlotinib hydrochloride  (ISO)
ethanol  (ISO)
flavokawain B  (ISO)
flavonoids  (ISO)
flutamide  (ISO)
folic acid  (EXP)
fructose  (EXP)
fulvestrant  (ISO)
gentamycin  (ISO)
geraniol  (ISO)
glafenine  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glyphosate  (ISO)
GSK2656157  (EXP,ISO)
Guanabenz  (EXP,ISO)
hexadecanoic acid  (EXP)
homocysteic acid  (ISO)
homocysteine  (ISO)
hydrogen peroxide  (ISO)
indoxyl sulfate  (EXP)
ketoconazole  (EXP)
L-1,4-dithiothreitol  (EXP)
lead diacetate  (ISO)
lead(II) chloride  (ISO)
leflunomide  (ISO)
linsidomine  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
losartan  (ISO)
luteolin  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melatonin  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methylmercury chloride  (EXP)
mevastatin  (EXP)
minocycline  (EXP,ISO)
mitoxantrone  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methylnicotinate  (EXP)
naloxone  (ISO)
nefazodone  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
nimesulide  (ISO)
okadaic acid  (ISO)
oxycodone  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP)
paraquat  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenethyl isothiocyanate  (EXP,ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
potassium atom  (ISO)
proanthocyanidin  (ISO)
pyrazinecarboxamide  (ISO)
quercetin  (ISO)
quinolinic acid  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
rotenone  (EXP,ISO)
salubrinal  (EXP,ISO)
Salvianolic acid A  (EXP)
SB 203580  (EXP)
SB 431542  (ISO)
scopolamine  (ISO)
selenomethionine  (ISO)
sertraline  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
staurosporine  (EXP)
succimer  (EXP)
sulforaphane  (ISO)
T-2 toxin  (ISO)
tamoxifen  (EXP)
tauroursodeoxycholic acid  (ISO)
tenofovir disoproxil fumarate  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP,ISO)
thioacetamide  (ISO)
thiostrepton  (ISO)
titanium dioxide  (EXP)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
triclocarban  (ISO)
trimellitic anhydride  (EXP)
troglitazone  (ISO)
trovafloxacin  (ISO)
tunicamycin  (EXP,ISO)
ursolic acid  (ISO)
valproic acid  (EXP,ISO)
zidovudine  (ISO)
zinc oxide  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Althausen S, etal., J Neurochem. 2001 Aug;78(4):779-87.
2. Burda J, etal., Biochem J. 1994 Sep 1;302 ( Pt 2):335-8.
3. Goldstein EN, etal., Acta Neuropathol. 1999 Nov;98(5):493-505.
4. Han XH, etal., Zhonghua Gan Zang Bing Za Zhi. 2010 Oct;18(10):768-72. doi: 10.3760/cma.j.issn.1007-3418.2010.10.011.
5. Hinnebusch AG and Lorsch JR, Cold Spring Harb Perspect Biol. 2012 Oct 1;4(10). pii: a011544. doi: 10.1101/cshperspect.a011544.
6. Hinnebusch AG Annu Rev Biochem. 2014;83:779-812. doi: 10.1146/annurev-biochem-060713-035802. Epub 2014 Jan 29.
7. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
8. Kimball SR, etal., Am J Physiol Endocrinol Metab. 2004 Oct;287(4):E772-80. Epub 2004 Jun 8.
9. Lourenco MV, etal., Cell Metab. 2013 Dec 3;18(6):831-43. doi: 10.1016/j.cmet.2013.11.002.
10. MGD and Homologene mouse data transfer
11. MGD data from the GO Consortium
12. MGD IEA
13. Montie HL, etal., Biochim Biophys Acta. 2005 Sep 25;1741(3):314-24.
14. Nakka VP, etal., Neurotox Res. 2010 Feb;17(2):189-202. doi: 10.1007/s12640-009-9110-5.
15. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
16. Paccalin M, etal., Dement Geriatr Cogn Disord. 2006;22(4):320-6. Epub 2006 Sep 4.
17. Petrov T, etal., J Neurotrauma. 2001 Aug;18(8):799-812.
18. Pipeline to import KEGG annotations from KEGG into RGD
19. RGD automated import pipeline
20. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. RGD automated import pipeline for gene-chemical interactions
22. Unterberger U, etal., J Neuropathol Exp Neurol. 2006 Apr;65(4):348-57.
23. Vary TC, etal., Am J Physiol. 1994 Feb;266(2 Pt 1):E193-201.
24. Wu CX, etal., Neurosci Lett. 2013 Jun 24;546:57-62. doi: 10.1016/j.neulet.2013.04.060. Epub 2013 May 10.
Additional References at PubMed
PMID:2808516   PMID:8889548   PMID:9746750   PMID:10349636   PMID:10882104   PMID:10882126   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11106749   PMID:11430820   PMID:12176355  
PMID:12388085   PMID:12477932   PMID:12520002   PMID:12897138   PMID:12904583   PMID:14610273   PMID:14638860   PMID:15475356   PMID:15489334   PMID:15542827   PMID:15544353   PMID:15684420  
PMID:15684421   PMID:15705563   PMID:15735755   PMID:15774759   PMID:15788409   PMID:15930128   PMID:15937339   PMID:15980866   PMID:16000157   PMID:16141072   PMID:16141073   PMID:16176978  
PMID:16377306   PMID:16439558   PMID:16452087   PMID:16492139   PMID:16794605   PMID:16835242   PMID:17090218   PMID:17170114   PMID:17274640   PMID:17309103   PMID:17325203   PMID:17418795  
PMID:17596516   PMID:18052927   PMID:18362164   PMID:18378896   PMID:18604219   PMID:18776938   PMID:18799693   PMID:19017641   PMID:19139267   PMID:19181853   PMID:19470760   PMID:19583950  
PMID:19754954   PMID:19759130   PMID:19846675   PMID:19861488   PMID:20029030   PMID:20034494   PMID:20072654   PMID:20559319   PMID:20886088   PMID:21076179   PMID:21223507   PMID:21267068  
PMID:21565905   PMID:21677750   PMID:21873635   PMID:21880833   PMID:22009178   PMID:22153080   PMID:22509299   PMID:22833567   PMID:22883908   PMID:23000413   PMID:23022383   PMID:23314846  
PMID:23354132   PMID:23665500   PMID:23933749   PMID:24457600   PMID:24594939   PMID:24648524   PMID:24726366   PMID:24889041   PMID:24974795   PMID:25332179   PMID:25537833   PMID:25590801  
PMID:25695629   PMID:25883808   PMID:26031337   PMID:26167872   PMID:26173459   PMID:26400930   PMID:26414443   PMID:26816051   PMID:26928076   PMID:26928234   PMID:26982722   PMID:27225776  
PMID:27416896   PMID:27430620   PMID:27613409   PMID:27698114   PMID:27746211   PMID:27960077   PMID:28320871   PMID:28378742   PMID:28478109   PMID:28726788   PMID:29289717   PMID:29295856  
PMID:29518331   PMID:29530978   PMID:30201312   PMID:30417358   PMID:30595499   PMID:30635284   PMID:31138784   PMID:31522764   PMID:31554636   PMID:31727829   PMID:31801950   PMID:31894919  
PMID:31905741   PMID:32150794   PMID:32325033   PMID:33029011  


Genomics

Comparative Map Data
Eif2s1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391278,908,846 - 78,933,784 (+)NCBIGRCm39mm39
GRCm381278,862,072 - 78,887,010 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1278,861,819 - 78,887,010 (+)EnsemblGRCm38mm10GRCm38
MGSCv371279,963,059 - 79,987,997 (+)NCBIGRCm37mm9NCBIm37
MGSCv361279,780,910 - 79,804,371 (+)NCBImm8
Celera1280,326,532 - 80,351,470 (+)NCBICelera
Cytogenetic Map12C3NCBI
EIF2S1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1467,360,328 - 67,386,516 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1467,360,151 - 67,386,516 (+)EnsemblGRCh38hg38GRCh38
GRCh381467,360,328 - 67,386,516 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371467,827,034 - 67,853,233 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh371467,827,045 - 67,853,233 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361466,896,787 - 66,922,986 (+)NCBINCBI36hg18NCBI36
Build 341466,896,837 - 66,921,909NCBI
Celera1447,886,088 - 47,912,287 (+)NCBI
Cytogenetic Map14q23.3NCBI
HuRef1447,996,958 - 48,023,152 (+)NCBIHuRef
CHM1_11467,765,718 - 67,791,923 (+)NCBICHM1_1
Eif2s1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2697,672,829 - 97,697,499 (+)NCBI
Rnor_6.0 Ensembl6102,048,372 - 102,073,041 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.06102,048,372 - 102,073,041 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.06111,422,397 - 111,447,066 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46101,495,444 - 101,520,113 (+)NCBIRGSC3.4rn4RGSC3.4
Celera696,060,793 - 96,085,462 (+)NCBICelera
Cytogenetic Map6q24NCBI
Eif2s1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554662,838,785 - 2,855,172 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554662,838,785 - 2,855,443 (-)NCBIChiLan1.0ChiLan1.0
EIF2S1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11466,813,953 - 66,839,866 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1466,813,953 - 66,839,866 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01447,935,691 - 47,960,055 (+)NCBIMhudiblu_PPA_v0panPan3
EIF2S1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl841,351,244 - 41,371,056 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1841,354,400 - 41,371,676 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Eif2s1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493649510,746,687 - 10,769,304 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EIF2S1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl791,085,335 - 91,109,829 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1791,085,025 - 91,109,835 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2797,394,525 - 97,417,715 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EIF2S1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12444,599,017 - 44,623,723 (+)NCBI
ChlSab1.1 Ensembl2444,598,287 - 44,623,298 (+)Ensembl
Eif2s1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473433,624,246 - 33,640,667 (-)NCBI

Position Markers
Eif2a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12D1UniSTS
cM Map12 UniSTS
cM MapUN UniSTS
cM Map15 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226753Femd7_mfemur midshaft diameter 7, 10 week (mouse)12950000084100000Mouse
13207568Tcq14_mtotal cholesterol QTL 14 (mouse)121161000097210000Mouse
1558978Cplaq10_mcircadian period of locomotor activity 10 (mouse)Not determined121529102578993590Mouse
1301574Lmblgq5_mlimb length QTL 5 (mouse)Not determined121754644680910109Mouse
4142002Tbqt3_mtibia bone quality traits 3 (mouse)Not determined1235235497109969809Mouse
1357479Splwt1_mspleen weight 1 (mouse)Not determined124164639290920752Mouse
1357757Lnopy2_mlens opacity 2 (mouse)Not determined125279985286800022Mouse
1357749Vtbt13_mvertebral trabecular bone trait 13 (mouse)Not determined125308522887085371Mouse
12832727Ahrq1_mairway hyperresponsiveness QTL 1 (mouse)125464912582619165Mouse
4140993Tglq2b_mtriglyceride QTL 2b (mouse)Not determined125529146189291675Mouse
9850127Tglq6_mtriglyceride QTL6 (mouse)Not determined125529146189291675Mouse
27226728Tibl20_mtibia length 20, 16 week (mouse)125910000093900000Mouse
27226776Tibl6_mtibia length 6, 5 week (mouse)126060000092700000Mouse
10043948Pbft6_mpercent body fat 6 (mouse)Not determined126115865395158653Mouse
1301476Pbwg12_mpostnatal body weight growth 12 (mouse)Not determined126199339095993590Mouse
27226797Scvln19_msacral vertebrae length 2, 16 week (mouse)126210000099500000Mouse
10043895Bw20_mbody weight QTL 20 (mouse)Not determined126226147896261478Mouse
1301046Par3_mpulmonary adenoma resistance 3 (mouse)Not determined126390993497910109Mouse
1301337Cdcs8_mcytokine deficiency colitis susceptibility 8 (mouse)Not determined126464230998642455Mouse
1300633Cdcs7_mcytokine deficiency colitis susceptibility 7 (mouse)Not determined126464230998642455Mouse
14746976Manh73_mmandible shape 73 (mouse)126581035799810357Mouse
27226771Tibl14_mtibia length 14, 10 week (mouse)126830000098800000Mouse
27226793Feml10_mfemur length 10, 5 week (mouse)1268300000113400000Mouse
4141738Tgq23_mtriglyceride QTL 23 (mouse)Not determined72146107106146107Mouse
1301689Skull18_mskull morphology 18 (mouse)Not determined1273920648107920752Mouse
1301926Adip6_madiposity 6 (mouse)Not determined1273920648107920752Mouse
13524842Ppiq10a_mprepulse inhibition QTL 10a (mouse)1277545446111545446Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:590
Count of miRNA genes:366
Interacting mature miRNAs:457
Transcripts:ENSMUST00000071230
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000071230   ⟹   ENSMUSP00000071214
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1278,861,819 - 78,887,010 (+)Ensembl
RefSeq Acc Id: ENSMUST00000219754
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1278,862,085 - 78,863,726 (+)Ensembl
RefSeq Acc Id: ENSMUST00000220382
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1278,862,130 - 78,881,174 (+)Ensembl
RefSeq Acc Id: NM_026114   ⟹   NP_080390
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391278,908,846 - 78,933,784 (+)NCBI
GRCm381278,862,072 - 78,887,010 (+)ENTREZGENE
MGSCv371279,963,059 - 79,987,997 (+)RGD
Celera1280,326,532 - 80,351,470 (+)RGD
cM Map12 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_080390   ⟸   NM_026114
- UniProtKB: Q6ZWX6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000071214   ⟸   ENSMUST00000071230
Protein Domains
S1 motif

Promoters
RGD ID:8678622
Promoter ID:EPDNEW_M17341
Type:initiation region
Name:Eif2s1_1
Description:Mus musculus eukaryotic translation initiation factor 2, subunit1 alpha , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381278,862,070 - 78,862,130EPDNEW
RGD ID:6822750
Promoter ID:MM_KWN:12022
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_023721,   OTTMUST00000077865
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361279,961,986 - 79,963,157 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:95299 AgrOrtholog
Ensembl Genes ENSMUSG00000021116 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000071214 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000071230 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.150.190 UniProtKB/Swiss-Prot
  3.30.70.1130 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro NA-bd_OB-fold UniProtKB/Swiss-Prot
  S1_dom UniProtKB/Swiss-Prot
  S1_domain UniProtKB/Swiss-Prot
  S1_IF2_alpha UniProtKB/Swiss-Prot
  TIF2_asu_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIF2_asu_middle_sf UniProtKB/Swiss-Prot
  TIF_2_asu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:13665 UniProtKB/Swiss-Prot
MGD MGI:95299 ENTREZGENE
NCBI Gene 13665 ENTREZGENE
PANTHER PTHR10602 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EIF_2_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00575 UniProtKB/Swiss-Prot
PhenoGen Eif2s1 PhenoGen
PROSITE PS50126 UniProtKB/Swiss-Prot
SMART SM00316 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF110993 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF116742 UniProtKB/Swiss-Prot
  SSF50249 UniProtKB/Swiss-Prot
UniProt IF2A_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q9CV24_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q3TIQ0 UniProtKB/Swiss-Prot