Eif2s2 (eukaryotic translation initiation factor 2 subunit beta) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Eif2s2 (eukaryotic translation initiation factor 2 subunit beta) Rattus norvegicus
Analyze
Symbol: Eif2s2
Name: eukaryotic translation initiation factor 2 subunit beta
RGD ID: 735192
Description: Predicted to enable mRNA binding activity; translation initiation factor activity; and translation initiation factor binding activity. Predicted to be involved in formation of translation preinitiation complex. Predicted to act upstream of or within in utero embryonic development; male germ cell proliferation; and male gonad development. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation initiation factor 2 complex. Predicted to be active in synapse. Orthologous to human EIF2S2 (eukaryotic translation initiation factor 2 subunit beta); PARTICIPATES IN translation initiation pathway; RNA transport pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: eukaryotic translation initiation factor 2 subunit 2; eukaryotic translation initiation factor 2 subunit 2 beta; eukaryotic translation initiation factor 2, subunit 2 (beta); eukaryotic translation initiation factor 2, subunit 2 beta; eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83163,834,846 - 163,855,733 (-)NCBIGRCr8
mRatBN7.23143,374,652 - 143,395,460 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3143,373,686 - 143,395,432 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3147,242,233 - 147,262,956 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03155,859,527 - 155,880,249 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03153,599,051 - 153,619,774 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03150,391,455 - 150,412,179 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3150,391,460 - 150,412,179 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03156,763,133 - 156,783,857 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43145,346,392 - 145,367,117 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3142,104,837 - 142,125,482 (-)NCBICelera
Cytogenetic Map3q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
arsenite(3-)  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
chloroacetaldehyde  (ISO)
chromium(6+)  (ISO)
clodronic acid  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (ISO)
cyclosporin A  (EXP)
deguelin  (ISO)
deoxynivalenol  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
estriol  (ISO)
etoposide  (ISO)
fenofibrate  (EXP)
fenpyroximate  (ISO)
fenthion  (ISO)
flutamide  (EXP)
FR900359  (ISO)
genistein  (ISO)
gentamycin  (EXP)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
metformin  (EXP)
methidathion  (ISO)
methimazole  (EXP)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
Nutlin-3  (ISO)
ochratoxin A  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
pentachlorophenol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phosgene  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamoxifen  (EXP,ISO)
tebufenpyrad  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
thifluzamide  (ISO)
thiram  (ISO)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Recognition of 5'-terminal TAR structure in human immunodeficiency virus-1 mRNA by eukaryotic translation initiation factor 2. Ben-Asouli Y, etal., Nucleic Acids Res 2000 Feb 15;28(4):1011-8.
2. Shape and location of eukaryotic initiation factor eIF-2 on the 40S ribosomal subunit of rat liver. Immunoelectron-microscopic and hydrodynamic investigations. Bommer UA, etal., Eur J Biochem. 1988 Mar 15;172(3):653-62.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Deletion of eIF2beta suppresses testicular cancer incidence and causes recessive lethality in agouti-yellow mice. Heaney JD, etal., Hum Mol Genet. 2009 Apr 15;18(8):1395-404. doi: 10.1093/hmg/ddp045. Epub 2009 Jan 23.
5. The mechanism of eukaryotic translation initiation: new insights and challenges. Hinnebusch AG and Lorsch JR, Cold Spring Harb Perspect Biol. 2012 Oct 1;4(10). pii: a011544. doi: 10.1101/cshperspect.a011544.
6. The scanning mechanism of eukaryotic translation initiation. Hinnebusch AG Annu Rev Biochem. 2014;83:779-812. doi: 10.1146/annurev-biochem-060713-035802. Epub 2014 Jan 29.
7. Modulation of protein translation by Nck-1. Kebache S, etal., Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5406-11.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:12426392   PMID:16289705   PMID:22658674   PMID:22681889   PMID:23063529   PMID:31505169   PMID:35352799  


Genomics

Comparative Map Data
Eif2s2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83163,834,846 - 163,855,733 (-)NCBIGRCr8
mRatBN7.23143,374,652 - 143,395,460 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3143,373,686 - 143,395,432 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3147,242,233 - 147,262,956 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03155,859,527 - 155,880,249 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03153,599,051 - 153,619,774 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03150,391,455 - 150,412,179 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3150,391,460 - 150,412,179 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03156,763,133 - 156,783,857 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43145,346,392 - 145,367,117 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3142,104,837 - 142,125,482 (-)NCBICelera
Cytogenetic Map3q41NCBI
EIF2S2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382034,088,309 - 34,112,243 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2034,088,309 - 34,112,243 (-)EnsemblGRCh38hg38GRCh38
GRCh372032,676,115 - 32,700,049 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362032,139,776 - 32,163,746 (-)NCBINCBI36Build 36hg18NCBI36
Build 342032,140,897 - 32,163,715NCBI
Celera2029,428,928 - 29,452,894 (-)NCBICelera
Cytogenetic Map20q11.22NCBI
HuRef2029,461,069 - 29,484,975 (-)NCBIHuRef
CHM1_12032,577,602 - 32,601,564 (-)NCBICHM1_1
T2T-CHM13v2.02035,814,716 - 35,838,620 (-)NCBIT2T-CHM13v2.0
Eif2s2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392154,713,330 - 154,734,826 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2154,713,330 - 154,734,855 (-)EnsemblGRCm39 Ensembl
GRCm382154,871,410 - 154,892,906 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2154,871,410 - 154,892,935 (-)EnsemblGRCm38mm10GRCm38
MGSCv372154,697,146 - 154,718,642 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362154,562,857 - 154,584,223 (-)NCBIMGSCv36mm8
Celera2160,799,391 - 160,820,843 (-)NCBICelera
Cytogenetic Map2H1NCBI
cM Map276.89NCBI
Eif2s2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542227,245,381 - 27,263,342 (+)NCBIChiLan1.0ChiLan1.0
EIF2S2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22139,784,143 - 39,807,048 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12039,777,245 - 39,800,150 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02030,380,226 - 30,403,049 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12031,519,355 - 31,542,239 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2031,519,355 - 31,542,239 (-)Ensemblpanpan1.1panPan2
EIF2S2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12423,268,263 - 23,289,038 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2423,269,309 - 23,288,988 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2422,912,872 - 22,933,657 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02423,955,345 - 23,976,094 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2423,955,346 - 23,976,051 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12423,247,718 - 23,268,509 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02423,341,642 - 23,362,436 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02423,778,738 - 23,799,526 (-)NCBIUU_Cfam_GSD_1.0
Eif2s2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640172,200,278 - 172,220,344 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365616,529,162 - 6,549,714 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365616,529,204 - 6,548,126 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EIF2S2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1737,538,321 - 37,570,224 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11737,551,182 - 37,570,269 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21742,530,767 - 42,538,136 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EIF2S2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1238,366,880 - 38,391,904 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605088,489,423 - 88,513,410 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eif2s2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248425,212,743 - 5,231,280 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248425,212,720 - 5,231,280 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Eif2s2
30 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:101
Count of miRNA genes:90
Interacting mature miRNAs:94
Transcripts:ENSRNOT00000023786
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141339236155617360Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141339013162184794Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3121056165145956249Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3121056165157309487Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3140069424146976080Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat

Markers in Region
RH142623  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23143,376,779 - 143,376,903 (+)MAPPERmRatBN7.2
Rnor_6.03150,393,583 - 150,393,706NCBIRnor6.0
Rnor_5.03156,765,261 - 156,765,384UniSTSRnor5.0
RGSC_v3.43145,348,520 - 145,348,643UniSTSRGSC3.4
Celera3142,106,965 - 142,107,088UniSTS
RH 3.4 Map31292.2UniSTS
Cytogenetic Map3q42UniSTS
BF416439  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23143,394,692 - 143,394,810 (+)MAPPERmRatBN7.2
Rnor_6.03150,411,491 - 150,411,608NCBIRnor6.0
Rnor_5.03156,783,169 - 156,783,286UniSTSRnor5.0
RGSC_v3.43145,366,429 - 145,366,546UniSTSRGSC3.4
Celera3142,124,794 - 142,124,911UniSTS
RH 3.4 Map31295.4UniSTS
Cytogenetic Map3q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_199380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC135822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC062402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000023786   ⟹   ENSRNOP00000023786
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3143,373,686 - 143,395,403 (-)Ensembl
Rnor_6.0 Ensembl3150,391,460 - 150,412,179 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110685   ⟹   ENSRNOP00000081256
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3143,374,721 - 143,395,432 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112261   ⟹   ENSRNOP00000086757
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3143,373,686 - 143,390,265 (-)Ensembl
RefSeq Acc Id: NM_199380   ⟹   NP_955412
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83163,834,846 - 163,855,570 (-)NCBI
mRatBN7.23143,374,652 - 143,395,381 (-)NCBI
Rnor_6.03150,391,455 - 150,412,179 (-)NCBI
Rnor_5.03156,763,133 - 156,783,857 (-)NCBI
RGSC_v3.43145,346,392 - 145,367,117 (-)RGD
Celera3142,104,837 - 142,125,482 (-)RGD
Sequence:
RefSeq Acc Id: XM_063283372   ⟹   XP_063139442
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83163,834,915 - 163,855,357 (-)NCBI
RefSeq Acc Id: XM_063283373   ⟹   XP_063139443
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83163,836,095 - 163,855,733 (-)NCBI
RefSeq Acc Id: NP_955412   ⟸   NM_199380
- UniProtKB: Q6P685 (UniProtKB/TrEMBL),   A6KI11 (UniProtKB/TrEMBL),   A0A8I6A6W5 (UniProtKB/TrEMBL),   F7FE42 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023786   ⟸   ENSRNOT00000023786
Ensembl Acc Id: ENSRNOP00000081256   ⟸   ENSRNOT00000110685
Ensembl Acc Id: ENSRNOP00000086757   ⟸   ENSRNOT00000112261
RefSeq Acc Id: XP_063139442   ⟸   XM_063283372
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A6W5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139443   ⟸   XM_063283373
- Peptide Label: isoform X2
Protein Domains
Translation initiation factor IF2/IF5

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6P685-F1-model_v2 AlphaFold Q6P685 1-333 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692578
Promoter ID:EPDNEW_R3103
Type:initiation region
Name:Eif2s2_1
Description:eukaryotic translation initiation factor 2 subunit beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03150,412,201 - 150,412,261EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735192 AgrOrtholog
BioCyc Gene G2FUF-47159 BioCyc
Ensembl Genes ENSRNOG00000017447 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023786.6 UniProtKB/TrEMBL
  ENSRNOT00000110685.1 UniProtKB/TrEMBL
  ENSRNOT00000112261.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.30.170 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5621303 IMAGE-MGC_LOAD
InterPro IF2/IF5 UniProtKB/TrEMBL
  Transl_init_fac_IF2/IF5 UniProtKB/TrEMBL
  Transl_init_fac_IF2/IF5_N UniProtKB/TrEMBL
  Transl_init_fac_IF2/IF5_Zn-bd UniProtKB/TrEMBL
KEGG Report rno:296302 UniProtKB/TrEMBL
MGC_CLONE MGC:72558 IMAGE-MGC_LOAD
NCBI Gene 296302 ENTREZGENE
PANTHER EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 2 UniProtKB/TrEMBL
  PTHR23001 UniProtKB/TrEMBL
Pfam eIF-5_eIF-2B UniProtKB/TrEMBL
PhenoGen Eif2s2 PhenoGen
RatGTEx ENSRNOG00000017447 RatGTEx
SMART eIF2B_5 UniProtKB/TrEMBL
Superfamily-SCOP Transl_init_fac_IF2/IF5_N UniProtKB/TrEMBL
  Transl_init_fac_IF2/IF5_Zn-bd UniProtKB/TrEMBL
UniProt A0A8I6A6W5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G5P0_RAT UniProtKB/TrEMBL
  A6KI10_RAT UniProtKB/TrEMBL
  A6KI11 ENTREZGENE, UniProtKB/TrEMBL
  F7FE42 ENTREZGENE, UniProtKB/TrEMBL
  Q6P685 ENTREZGENE
UniProt Secondary Q6P685 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-31 Eif2s2  eukaryotic translation initiation factor 2 subunit beta  Eif2s2  eukaryotic translation initiation factor 2 subunit 2 beta  Name changed 629549 APPROVED
2016-02-26 Eif2s2  eukaryotic translation initiation factor 2 subunit 2 beta  Eif2s2  eukaryotic translation initiation factor 2 subunit 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-25 Eif2s2  eukaryotic translation initiation factor 2 subunit 2  Eif2s2  eukaryotic translation initiation factor 2, subunit 2 beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-11-06 Eif2s2  eukaryotic translation initiation factor 2, subunit 2 beta  Eif2s2  eukaryotic translation initiation factor 2, subunit 2 (beta)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Eif2s2  eukaryotic translation initiation factor 2, subunit 2 (beta)    eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa  Name updated 1299863 APPROVED