Eif2s3 (eukaryotic translation initiation factor 2 subunit gamma) - Rat Genome Database

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Gene: Eif2s3 (eukaryotic translation initiation factor 2 subunit gamma) Rattus norvegicus
Analyze
Symbol: Eif2s3
Name: eukaryotic translation initiation factor 2 subunit gamma
RGD ID: 1561279
Description: Predicted to have translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to localize to eukaryotic translation initiation factor 2 complex. Human ortholog(s) of this gene implicated in MEHMO syndrome. Orthologous to human EIF2S3 (eukaryotic translation initiation factor 2 subunit gamma); PARTICIPATES IN translation initiation pathway; INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; aconitine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: eIF-2-gamma; eIF-2-gamma X; Eif2g; Eif2s3x; Eukaryotic translation initiation factor 2 subunit 3; eukaryotic translation initiation factor 2 subunit 3, X-linked; eukaryotic translation initiation factor 2 subunit gamma, X-linked; eukaryotic translation initiation factor 2, subunit 3 gamma; eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked; PP42
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X58,916,513 - 58,939,923 (-)NCBI
Rnor_6.0 EnsemblX63,268,037 - 63,292,092 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0X63,268,106 - 63,291,125 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X63,861,008 - 63,884,027 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X81,542,853 - 81,566,259 (-)NCBIRGSC3.4rn4RGSC3.4
CeleraX59,352,186 - 59,375,591 (-)NCBICelera
Cytogenetic MapXq22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:8780732   PMID:8889548   PMID:10900014   PMID:12426392   PMID:16289705   PMID:16854843   PMID:20458337   PMID:23063529   PMID:25468996  


Genomics

Comparative Map Data
Eif2s3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X58,916,513 - 58,939,923 (-)NCBI
Rnor_6.0 EnsemblX63,268,037 - 63,292,092 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0X63,268,106 - 63,291,125 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X63,861,008 - 63,884,027 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X81,542,853 - 81,566,259 (-)NCBIRGSC3.4rn4RGSC3.4
CeleraX59,352,186 - 59,375,591 (-)NCBICelera
Cytogenetic MapXq22NCBI
EIF2S3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX24,054,946 - 24,078,810 (+)EnsemblGRCh38hg38GRCh38
GRCh38X24,054,956 - 24,078,810 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X24,073,073 - 24,096,927 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X23,982,986 - 24,006,848 (+)NCBINCBI36hg18NCBI36
Build 34X23,832,721 - 23,855,743NCBI
CeleraX28,196,181 - 28,220,053 (+)NCBI
Cytogenetic MapXp22.11NCBI
HuRefX21,816,175 - 21,839,574 (+)NCBIHuRef
CHM1_1X24,104,271 - 24,128,153 (+)NCBICHM1_1
Eif2s3x
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X93,232,315 - 93,256,257 (-)NCBIGRCm39mm39
GRCm39 EnsemblX93,232,313 - 93,256,468 (-)Ensembl
GRCm38X94,188,709 - 94,212,651 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX94,188,707 - 94,212,862 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X91,434,048 - 91,457,990 (-)NCBIGRCm37mm9NCBIm37
MGSCv36X90,441,428 - 90,465,370 (-)NCBImm8
CeleraX81,110,914 - 81,134,502 (-)NCBICelera
Cytogenetic MapXC3NCBI
cM MapX41.52NCBI
Eif2s3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555094,437,044 - 4,457,819 (+)NCBIChiLan1.0ChiLan1.0
EIF2S3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X24,027,099 - 24,050,879 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX24,027,099 - 24,050,879 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X16,653,762 - 16,678,198 (+)NCBIMhudiblu_PPA_v0panPan3
EIF2S3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X19,662,132 - 19,680,223 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX19,650,343 - 19,680,221 (+)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0X19,617,765 - 19,635,846 (+)NCBI
UMICH_Zoey_3.1X19,656,521 - 19,674,614 (+)NCBI
UNSW_CanFamBas_1.0X19,689,972 - 19,708,341 (+)NCBI
UU_Cfam_GSD_1.0X19,746,165 - 19,764,509 (+)NCBI
Eif2s3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X12,622,024 - 12,641,621 (+)NCBI
SpeTri2.0NW_004936624516,206 - 535,749 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EIF2S3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1X20,129,708 - 20,162,881 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X21,554,153 - 21,587,126 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EIF2S3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X22,523,330 - 22,549,827 (+)NCBI
Vero_WHO_p1.0NW_02366605624,404,897 - 24,429,467 (+)NCBI
Eif2s3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624897424,144 - 445,698 (+)NCBI

Position Markers
RH17627  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X58,922,335 - 58,923,518 (+)MAPPER
Rnor_6.0X63,273,928 - 63,275,110NCBIRnor6.0
Rnor_5.0X63,866,830 - 63,868,012UniSTSRnor5.0
RGSC_v3.4X81,548,676 - 81,549,858UniSTSRGSC3.4
CeleraX59,358,008 - 59,359,190UniSTS
Cytogenetic MapXq31UniSTS
EIF2S3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X58,923,467 - 58,923,572 (+)MAPPER
Rnor_6.0X63,275,060 - 63,275,164NCBIRnor6.0
Rnor_5.0X63,867,962 - 63,868,066UniSTSRnor5.0
RGSC_v3.4X81,549,808 - 81,549,912UniSTSRGSC3.4
CeleraX59,359,140 - 59,359,244UniSTS
Cytogenetic MapXq31UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X15688119127888215Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X44320616158345622Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX44557974120045269Rat
70221Bp56Blood pressure QTL 564.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X6139809770352120Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:112
Count of miRNA genes:93
Interacting mature miRNAs:97
Transcripts:ENSRNOT00000058134
Prediction methods:Microtar, Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 10 74 35 36 11 8
Low 1 5
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000081124   ⟹   ENSRNOP00000072851
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX63,288,363 - 63,292,092 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000082421   ⟹   ENSRNOP00000074806
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX63,281,779 - 63,291,371 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092019   ⟹   ENSRNOP00000070817
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX63,268,037 - 63,291,107 (-)Ensembl
RefSeq Acc Id: NM_001100542   ⟹   NP_001094012
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X58,916,513 - 58,939,923 (-)NCBI
Rnor_6.0X63,268,106 - 63,291,125 (-)NCBI
Rnor_5.0X63,861,008 - 63,884,027 (-)NCBI
RGSC_v3.4X81,542,853 - 81,566,259 (-)RGD
CeleraX59,352,186 - 59,375,591 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001094012 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH91286 (Get FASTA)   NCBI Sequence Viewer  
  AAI66783 (Get FASTA)   NCBI Sequence Viewer  
  EDL96007 (Get FASTA)   NCBI Sequence Viewer  
  P81795 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001094012   ⟸   NM_001100542
- UniProtKB: P81795 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000070817   ⟸   ENSRNOT00000092019
RefSeq Acc Id: ENSRNOP00000074806   ⟸   ENSRNOT00000082421
RefSeq Acc Id: ENSRNOP00000072851   ⟸   ENSRNOT00000081124
Protein Domains
tr-type G

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701840
Promoter ID:EPDNEW_R12364
Type:multiple initiation site
Name:Eif2s3_1
Description:eukaryotic translation initiation factor 2 subunit gamma
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X63,291,120 - 63,291,180EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
X 63866899 63866900 C G snv SDLEF7/Barth (UDEL), LE/OrlBarth (UDEL), BDIX.Cg-Tal/NemOda (KyushuU), F344/NSlc (KyushuU), F344/DuCrlCrlj (KyushuU)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561279 AgrOrtholog
Ensembl Genes ENSRNOG00000060793 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000070817 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000072851 UniProtKB/TrEMBL
  ENSRNOP00000074806 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000081124 UniProtKB/TrEMBL
  ENSRNOT00000082421 UniProtKB/TrEMBL
  ENSRNOT00000092019 ENTREZGENE, UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7304876 IMAGE-MGC_LOAD
  IMAGE:7935021 IMAGE-MGC_LOAD
  IMAGE:9098876 IMAGE-MGC_LOAD
InterPro EFTu-like_2 UniProtKB/Swiss-Prot
  eIF2g_dom_2 UniProtKB/Swiss-Prot
  eIF2g_GTP-bd UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TF_GTP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIF2_gsu_C UniProtKB/Swiss-Prot
  Transl_B-barrel_sf UniProtKB/Swiss-Prot
  Transl_elong_EF1A/Init_IF2_C UniProtKB/Swiss-Prot
KEGG Report rno:299027 UniProtKB/Swiss-Prot
MGC_CLONE MGC:109183 IMAGE-MGC_LOAD
  MGC:187904 IMAGE-MGC_LOAD
  MGC:188564 IMAGE-MGC_LOAD
NCBI Gene 299027 ENTREZGENE
Pfam eIF2_C UniProtKB/Swiss-Prot
  GTP_EFTU UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GTP_EFTU_D2 UniProtKB/Swiss-Prot
PhenoGen Eif2s3 PhenoGen
PRINTS ELONGATNFCT UniProtKB/Swiss-Prot
PROSITE G_TR_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50447 UniProtKB/Swiss-Prot
  SSF50465 UniProtKB/Swiss-Prot
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A096MJB9_RAT UniProtKB/TrEMBL
  A0A1P0QU16_RAT UniProtKB/TrEMBL
  IF2G_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary B0BN96 UniProtKB/Swiss-Prot
  B2RYH8 UniProtKB/Swiss-Prot
  Q5BJX8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-09-09 Eif2s3  eukaryotic translation initiation factor 2 subunit gamma  Eif2s3  eukaryotic translation initiation factor 2, subunit 3 gamma  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-01-11 Eif2s3  eukaryotic translation initiation factor 2, subunit 3 gamma  Eif2s3x  eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Eif2s3x  eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked      Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 Eif2s3x  eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked      Symbol and Name status set to provisional 70820 PROVISIONAL