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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620963
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Eif2s1
Name: eukaryotic translation initiation factor 2 subunit alpha
Acc ID: CHEBI:9516
Term: thapsigargin
Definition: An organic heterotricyclic compound that is a hexa-oxygenated 6,7-guaianolide isolated fron the roots of Thapsia garganica L., Apiaceae. A potent skin irritant, it is used in traditional medicine as a counter-irritant. Thapsigargin inhibits Ca(2+)-transporting ATPase mediated uptake of calcium ions into sarcoplasmic reticulum and is used in experimentation examining the impacts of increasing cytosolic calcium concentrations.
Chemical ID: MESH:D019284
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Eif2s1increases expressionEXP 6480464CTDThapsigargin results in increased expression of EIF2S1 mRNAPMID:28844859
Eif2s1increases phosphorylationEXP 6480464CTDThapsigargin results in increased phosphorylation of EIF2S1 proteinPMID:16324875 PMID:28844859 PMID:35028790
Eif2s1multiple interactionsEXP 6480464CTDEIF2AK3 gene mutant form inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2S1 protein]; salubrinal inhibits the reaction [Thapsigargin results in increased expression of EIF2S1 mRNA]; shikonin inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2S1 protein]PMID:16324875 PMID:28844859 PMID:35028790
Eif2s1decreases phosphorylationISOEif2s1 (Mus musculus)6480464CTDThapsigargin results in decreased phosphorylation of EIF2S1 proteinPMID:29109149
Eif2s1decreases response to substanceISOEif2s1 (Mus musculus)6480464CTDEIF2S1 protein mutant form results in decreased susceptibility to ThapsigarginPMID:24315374
Eif2s1increases expressionISOEIF2S1 (Homo sapiens)6480464CTDThapsigargin results in increased expression of EIF2S1 protein modified formPMID:24224909
Eif2s1increases phosphorylationISOEif2s1 (Mus musculus)6480464CTDThapsigargin results in increased phosphorylation of EIF2S1 proteinPMID:23576437 PMID:24150608 PMID:24315374 PMID:24648495 PMID:30508555 PMID:32578922
Eif2s1increases phosphorylationISOEIF2S1 (Homo sapiens)6480464CTDThapsigargin results in increased phosphorylation of EIF2S1 proteinPMID:17553788 PMID:19233273 PMID:20022965 PMID:23576437 PMID:23690448 PMID:23741617 PMID:27587023 PMID:29109149 PMID:32357311 PMID:32407927
Eif2s1multiple interactionsISOEif2s1 (Mus musculus)6480464CTD1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2S1 protein]; EIF2S1 protein modified form affects the reaction [Thapsigargin results in increased expression of ATF4 mRNA]; EIF2S1 protein modified form affects the reaction [Thapsigargin results in increased expression of DDIT3 mRNA]; EIF2S1 protein modified form affects the reaction [Thapsigargin results in increased expression of DDIT3 protein]; EIF2S1 protein modified form affects the reaction [Thapsigargin results in increased expression of PPP1R15A mRNA]; EIF2S1 protein modified form affects the reaction [Thapsigargin results in increased expression of PPP1R15A protein]; EIF2S1 protein mutant form inhibits the reaction [Thapsigargin results in decreased expression of TIMM17A protein]; EIF2S1 protein mutant form inhibits the reaction [Thapsigargin results in increased expression of IBTK mRNA alternative form]; PTPN1 gene mutant form promotes the reaction [Thapsigargin results in increased activity of and results in increased phosphorylation of EIF2S1 protein]; Thapsigargin inhibits the reaction [7,14-dihydroxydocosa-4,8,10,12,16,19-hexaenoic acid inhibits the reaction [Palmitic Acid results in increased phosphorylation of EIF2S1 protein]]; Thapsigargin results in increased activity of and results in increased phosphorylation of EIF2S1 proteinPMID:22509299 PMID:23576437 PMID:24315374 PMID:24648495 PMID:29109149 PMID:29414781
Eif2s1multiple interactionsISOEIF2S1 (Homo sapiens)6480464CTD1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2S1 protein]; EIF2AK3 mutant form inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2S1 protein]; Luteolin inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2S1 protein]PMID:20022965 PMID:23576437 PMID:32407927
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