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ONTOLOGY REPORT - ANNOTATIONS


Term:varenicline
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Accession:CHEBI:84500 term browser browse the term
Definition:An organic heterotetracyclic compound that acts as a partial agonist for nicotinic cholinergic receptors and is used (in the form of its tartate salt) as an aid to giving up smoking.
Synonyms:exact_synonym: 7,8,9,10-tetrahydro-6H-6,10-methanoazepino[4,5-g]quinoxaline
 related_synonym: 7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino(2,3-h)(3)benzazepine;   Formula=C13H13N3;   InChI=1S/C13H13N3/c1-2-16-13-5-11-9-3-8(6-14-7-9)10(11)4-12(13)15-1/h1-2,4-5,8-9,14H,3,6-7H2/t8-,9+;   InChIKey=JQSHBVHOMNKWFT-DTORHVGOSA-N;   SMILES=C1[C@H]2CNC[C@@H]1c1cc3nccnc3cc21;   vareniclina;   vareniclinum
 xref: CAS:249296-44-4 "ChemIDplus";   CAS:249296-44-4 "KEGG DRUG";   DrugBank:DB01273;   Drug_Central:2808 "DrugCentral";   HMDB:HMDB0015398;   KEGG:D08669;   LINCS:LSM-5358
 xref_mesh: MESH:D000068580
 xref: PDBeChem:QMR;   PMID:24406270 "Europe PMC";   PMID:24652107 "Europe PMC";   PMID:24763764 "Europe PMC";   PMID:24856597 "Europe PMC";   PMID:24906297 "Europe PMC";   PMID:24949564 "Europe PMC";   PMID:25062287 "Europe PMC";   PMID:25145377 "Europe PMC";   PMID:25331778 "Europe PMC";   PMID:25352081 "Europe PMC";   PMID:25410148 "Europe PMC";   PMID:25449275 "Europe PMC";   PMID:25462656 "Europe PMC";   PMID:25475645 "Europe PMC";   PMID:25485645 "Europe PMC";   PMID:25497715 "Europe PMC";   PMID:25572451 "Europe PMC";   PMID:25588294 "Europe PMC";   PMID:25616031 "Europe PMC";   Reaxys:10668886 "Reaxys";   Wikipedia:Varenicline
 cyclic_relationship: is_conjugate_base_of CHEBI:84508


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varenicline term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apoe apolipoprotein E JBrowse link 1 80,612,894 80,616,820 RGD:6480464
G Cd36 CD36 molecule JBrowse link 4 14,150,309 14,191,498 RGD:6480464
G Cdh5 cadherin 5 JBrowse link 19 1,025,122 1,074,333 RGD:6480464
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit JBrowse link 8 59,594,007 59,607,122 RGD:6480464
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit JBrowse link 3 176,533,182 176,547,965 RGD:6480464
G Chrna6 cholinergic receptor nicotinic alpha 6 subunit JBrowse link 16 68,860,018 68,866,718 RGD:6480464
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit JBrowse link 1 123,897,341 124,039,263 RGD:6480464
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit JBrowse link 2 189,088,570 189,096,785 RGD:6480464
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit JBrowse link 8 59,610,489 59,629,073 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Olr1 oxidized low density lipoprotein receptor 1 JBrowse link 4 163,239,853 163,261,937 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Slc22a2 solute carrier family 22 member 2 JBrowse link 1 48,318,025 48,360,219 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19657
    role 19601
      biological role 19599
        pharmacological role 18680
          neurotransmitter agent 16228
            serotonergic drug 3850
              serotonergic agonist 881
                varenicline 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 19657
    subatomic particle 19653
      composite particle 19653
        hadron 19653
          baryon 19653
            nucleon 19653
              atomic nucleus 19653
                atom 19653
                  main group element atom 19534
                    main group molecular entity 19534
                      s-block molecular entity 19319
                        hydrogen molecular entity 19310
                          hydrides 18237
                            inorganic hydride 17105
                              pnictogen hydride 17063
                                nitrogen hydride 16886
                                  azane 16564
                                    ammonia 16561
                                      organic amino compound 16560
                                        secondary amino compound 6363
                                          varenicline 14
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